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Tesi sul tema "Glutathione"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Petit, Elise. "Etude des Glutathion Transférases : caractérisation de la classe Kappa et rôle de ces enzymes dans l'hépatotoxicité des Thiopurines." Rennes 1, 2007. http://www.theses.fr/2007REN1B072.

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Abstract (sommario):

Les Glutathion Tranférases (GST) constituent un système multienzymatique de détoxication. Elles sont impliquées dans la prévention , le développement des tumeurs et dans la réponse aux anticancéreux. Pendant ma thèse , je me suis intéressée à la GST de classe Kappa. Sa caractérisation nous a permis de mettre en évidence sa présence dans les mitochondries et les peroxysomes. Cette localisation particulière suggère que le GST Kappa pourrait avoir un rôle lié aux fonctions cellulaires de ces deux organites. Les GST étant en outre impliquées dans des phénomènes de résistance à des anticancéreux, j

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2

Van, Eldik Annamaria Johanna. "Synthesis of glutathione conjugates as selective inhibitors for parasitic glutathione S transferases." Thesis, De Montfort University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246521.

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3

Halfwassen, Kathrin. "Untersuchungen zu Glutathion-sensitiven Farbstoffen in der Meerschweinchen-Retina." Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-89656.

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Die Glutathionverhältnisse und -verschiebungen zwischen Gliazellen und Ganglienzellen vor und nach oxidativem Stress wurden erstmals im lebenden Zellverband, ex vivo, untersucht. Die Untersuchungen erfolgten an akut isoliertem Retinagewebe vom Meerschweinchen, von welchem Bilder am Laser scanning microscope (LSM) erstellt wurden. Über die Anwendung des in vivo-Fluoreszenzfarbstoffes CellTracker Green wurde dabei dessen Spezifität für Glutathion überprüft und bestätigt.

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4

Yang, Bo. "Biliary glutathione transport pathways." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/MQ52967.pdf.

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5

Lyon, Robert Patrick. "Enzymology at the dimer interface of cytosolic glutathione S-transferases /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/8165.

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6

Kearns, Pamela Renate. "The role of glutathione and mu class glutathione s-transferases in childhood acute leukaemia." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311134.

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7

Fläring, Urban. "Glutathione during stress in man /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-799-5/.

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8

Patzewitz, Eva-Maria. "Glutathione metabolism of Plasmodium falciparum." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/913/.

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Abstract (sommario):

Apicomplexan parasites of the genus Plasmodium are the causative agent of malaria, one of the most prevalent infectious diseases worldwide. Five different Plasmodium species can cause malaria in humans, leading to a total of approximately 500 million cases each year and of these, P. falciparum causes the most deadly form of the disease and is responsible for more than 1 million deaths annually. A major problem in the global fight against malaria is the widespread resistance of the parasites against the currently available drugs. It is of great importance to identify new drug target as well as

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9

Evans, D. C. "Renal processing of glutathione conjugates." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383757.

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10

Di, Ilio C. "Studies on bacterial glutathione transferase." Thesis, Cranfield University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333472.

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11

Praig, Vera Gertraud. "Immobilised glutathione for affinity binding." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620379.

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12

Knight, Simon Alexander Bowles 1961. "The use of anti-glutathione peroxidase antibodies in the study of selenium-dependent glutathione peroxidase." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276906.

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Abstract (sommario):

Liver glutathione peroxidase activity is affected by changes in selenium (Se) status. To investigate the effect of Se status on GSH-Px protein we prepared antibodies against rat liver GSH-Px and used them in an ELISA. The immunoreactivity of the anti-GSH-Px antibodies against GSH-Px was both tissue and species specific. When rats were depleted of Se, liver GSH-Px activity decreased exponentially to zero with a half-life of 2.8 d. Liver GSH-Px protein also decreased exponentially, but not to zero, with a longer half-life of 5.2 d. Dietary repletion of Se-deficient rats with 0.5 mg Se/kg diet in

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13

Saudrais, Élodie. "Mécanismes de neuroprotection liés au glutathion dans la barrière sang - liquide céphalorachidien choroïdienne au cours du développement périnatal." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1026/document.

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Plus de 50 % des handicaps neurodéveloppementaux sont dus à une exposition périnatale à des stress toxiques ou oxydants. Comprendre comment le cerveau est protégé au cours du développement périnatal et pourquoi ses mécanismes de défense sont dépassés lorsque l’enfant est soumis à un stress important est donc crucial. La barrière sang – liquide céphalorachidien (LCR), localisée au niveau des plexus choroïdes, présente une capacité de détoxification élevée et pourrait donc avoir un rôle prépondérant dans la protection du cerveau au stade périnatal. Nous avons étudié la capacité de plusieurs enzy

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14

Corrigall, Anne Vint. "Human glutathione S-transferases : characterization, tissue distribution and kinetic studies." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27205.

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In this study the purification of human basic and near-neutral liver, and human basic and acidic lung glutathione S-transferases (GSH S-T) was undertaken. Purification of the basic and near-neutral GSH S-T was achieved using a combination of affinity chromatography, chromatofocusing and immunoaffinity chromatography. Affinity and ion exchange chromatography were employed in the purification of the basic and acidic lung forms. The purified proteins had similar physicochemical characteristics to the GSH S-T purified by others. The binding of 1-chloro-2,4-dinitrobenzene (CDNB) to the 3 classes of

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15

Nieslanik, Brenda Sue. "A structure-function analysis of the C-terminus in glutathione S-transferase A1-1 /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/8163.

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16

Rogers, Lynette K. "Mechanisms of nuclear localization of glutathione reductase, subnuclear colocalization with thioredoxin, and genetic analysis of a chemically induced glutathione reductase knockout." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1091194762.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 133 p.; also includes graphics (some col.). Includes bibliographical references (p. 124-133).

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17

Jorgensen, Karen Virginia. "EFFECTS OF GLUTATHIONE AND GLUTATHIONE-S - TRANSFERASE ON AFLATOXIN B(,1) MUTAGENESIS IN THE AMES TEST." Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275310.

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18

Goold, Richard David. "The glutathione S-transferases : kinetics, binding and inhibition." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27175.

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Abstract (sommario):

The glutathione S-transferases are a group of enzymes which catalyse the conjugation of reduced glutathione with a variety of electrophilic molecules, and they are therefore thought to play a major role in drug biotransformation and the detoxification of xenobiotics. The cytosolic GSH S-transferase isoenzymes of rat, man and mouse have been assigned to three groups, Alpha, Mu and Pi, based on N-terrninal amino acid sequences, substrate specificities, immunological cross-reactivity and sensitivities to inhibitors. The kinetic mechanism of the GSH S-transferases is controversial, due to the obse

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19

Njålsson, Runa Viđarr. "Molecular aspects of glutathione synthetase deficiency /." Stockholm, 2004. http://diss.kib.ki.se/2003/91-7349-808-4.

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20

Dixon, David Peter. "Glutathione transferases in maize (Zea mays)." Thesis, Durham University, 1998. http://etheses.dur.ac.uk/4788/.

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The glutathione transferases (GSTs) of maize have been the most studied GSTs in plants, however much is still not known about these enzymes. In the course of the current study six GST subunits (Zm GSTs I, II and III, which have been reported previously, and Zm GSTs V, VI and VII, which have not been previously reported) have been identified in the dimers Zm GST I-I, I-II, I-III, V-V, V-VI and V-VII. Maize GSTs are known to be important in herbicide detoxification and the purified maize enzymes were each found to have differing activities toward a number of herbicides, and also a range of other

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21

Dalton, K. G. "Glutathione transferase isoenzymes in rat hepatocarcinogenesis." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379829.

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22

Troughton, P. R. "Isoenzymes of rat glutathione S-transferase." Thesis, University of Bradford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371503.

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23

Dodd, Charlotte Claire. "The role of glutathione in hepatoprotection." Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250328.

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24

Fry, V. A. H. "Microglial glutathione and glutamate : regulation mechanisms." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18703/.

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Microglia, the immune cells of the central nervous system (CNS), are important in the protection of the CNS, but may be implicated in the pathogenesis of neuroinflammatory disease. Upon activation, microglia produce reactive oxygen and nitrogen species; intracellular antioxidants are therefore likely to be important in their self-defence. Here, it was confirmed that cultured microglia contain high levels of glutathione, the predominant intracellular antioxidant in mammalian cells. The activation of microglia with lipopolysaccharide (LPS) or LPS + interferon-gamma was shown to affect their glut

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25

Waller, Alan Richard. "Glutathione conjugation in non-human primates." Thesis, University of Surrey, 1985. http://epubs.surrey.ac.uk/848541/.

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The scientific literature indicates that the biotransformation of xenobiotics in man is more similar to that observed in the non-human primate than to other laboratory animal species. The main objective of the current investigation was to compare the ability of 3 species of non-human primate, the rhesus monkey (Macaca mulatta), the cynomolgus monkey (Macaca fascicularis) and the baboon (Papio species), to conjugate xenobiotics with glutathione since such information is lacking in the literature. The metabolism and pharmacokinetics of ethacrynic acid, a diuretic known to be extensively metaboli

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26

Hayes, Peter C. "Glutathione S-transferases in the pancreas." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/19832.

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Glutathione S-transferase (GST) is an important xenobiotic metabolising enzyme which has been extensively studied in the liver. In the first part of this study immunohistochemistry was used to identify the presence and histological localisation of different GST isoenzymes in various gastrointestinal tract tissues in the human in health and disease. GSTP was found throughout the gastrointestinal and biliary tract whilst the position and quantity of other isoenzymes varied locally. Increased expression of GSTP was observed in cholangiocarcinoma and colonic adenocarcinoma, but not hepatocellular

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27

Tamaki, Hisanori. "Studies on Yeast Glutathione S-Transferase." Kyoto University, 1991. http://hdl.handle.net/2433/168776.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>農学博士<br>甲第4688号<br>農博第649号<br>新制||農||585(附属図書館)<br>学位論文||H3||N2261(農学部図書室)<br>UT51-91-C106<br>京都大学大学院農学研究科食品工学専攻<br>(主査)教授栃倉辰六郎, 教授木村光, 教授佐々木隆造<br>学位規則第5条第1項該当

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28

Rawlinson, Rosemary Julia. "Glutathione and the cytosolic heme pool." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/glutathione-and-the-cytosolic-heme-pool(e78204fa-e583-41eb-ab9c-1a759b9abf33).html.

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Recently glutathione (GSH) has been proposed as a key component of the cytosolic iron pool, possessing a buffering role for cytosolic iron(II), protecting it from autoxidation. However the chemical nature of the cytosolic heme pool is unknown. We have investigated whether GSH binds heme iron. If so, the resulting complex would be expected to have increased stability and solubility in aqueous solutions, compared to the extremely hydrophobic heme molecule, thereby reducing its ability to partition into membranes. An interaction between glutathione and hematin was established with the affinity co

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29

Dixit, Vaishali S. "Inactivation of glutathione s transferase zeta by dichloroacetic acid." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010021.

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Thesis (Ph. D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 98 pages. Includes Vita. Includes bibliographical references.

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30

Yilmaz, Can. "Glutathione S-transferase Activity And Glutathione Levels In Drought Stressed Pinus Brutia Ten. Trees Growing In Ankara." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607732/index.pdf.

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Turkish red pine is coastal tree and is a drought resistant pine that withstands more aridity and poor soils than most other timber species growing in the same climatic conditions. In Turkey, this species grows in southern and western Anatolia and is also found in the Marmara region. Drought results in a water deficit in plant tissues, which, in turn, can lead to an imbalance in the redox poise of plant cells, and thus inducing oxidative stress in plants. Resistance to conditions associated with oxidative-stress must, in part, rely on endogenous antioxidative defense mechanisms required to

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31

Bryant, David. "Glutathione conjugation of herbicides and fungicides in plants and fungi : functional characterization of glutathione transferases from phytopathogens." Thesis, Durham University, 2004. http://etheses.dur.ac.uk/3117/.

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The aim of this research was to determine the relative importance of glutathione S-transferase (GST) mediated herbicide and fungicide detoxification in wheat plants and to functionally characterise GSTs cloned from phytopathogenic fungi. Wheat seedlings treated with and without safeners were used for in vivo and in vitro pesticide metabolism studies with the herbicide fenoxaprop-P-ethyl and the fungicide fluquinconazole, which are both known to undergo glutathione conjugation. Fenoxaprop-P-ethyl underwent rapid detoxification by this route and the rates of metabolism were enhanced in safener t

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32

Abdu, Habibu U. "Investigating the role of glutathione and glutathione biosynthetic genes in the adaptation of Anopheles gambiae to insecticides." Thesis, Abertay University, 2015. https://rke.abertay.ac.uk/en/studentTheses/d30eb4df-64c0-43fe-ba6d-0fe778ff6b80.

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Malaria remains a serious public health challenge in the tropical world, with 584,000 deaths globally in 2013, of which 90% occurred in Africa, and mostly in pregnant women and children under the age of five. Anopheles gambiae (An. gambiae) is the principal malaria vector in Africa, where vector control measures involve the use of insecticides in the forms of long-lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS). The development of insecticides resistance mitigates these approaches. Glutathione (GSH) is widely distributed among all living organisms, and is associated

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33

Dolan, Catherine. "Regulation of mouse hepatic glutathione S-transferases." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/23855.

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The glutathione S-transferases (GST) are a multi-gene family of dimeric proteins which catalyse the conjugation of glutathione to a wide range of electrophilic compounds. Three classes of mouse cytosolic GST have been isolated, alpha, mu and pi, comprising Ya-, Yb- and Yf-type subunits respectively. A marked sexual dimorphism in mouse hepatic GST has been observed. The YfYf GST is the most abundant form in the male, constituting approximately 70% of total hepatic GST content. By contrast, the Yf subunit represents only a minor form in the livers of female mice. The hormonal controls which regu

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34

Ristoff, Ellinor. "Inborn errors in the metabolism of glutathione /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-392-9/.

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35

Ren, Pei. "Glutathione reductase, redox homeostasis, and mitochondrial dysfunction." Thesis, Kent State University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1555282.

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<p> Overproduction of reactive oxygen species and increasing oxidative stress have emerged as the major factors leading to mitochondrial dysfunction during myocardial ischemia and reperfusion (I/R) injury. Under normal physiology conditions, glutathione (GSH) concentration is high in the mitochondrial redox pool However, GSH is oxidized to GSSG (oxidized glutathione) upon the exposure of oxidative stress, such as the overproduction of <sup>·</sup>O<sub> 2</sub><sup>–</sup> and <sup>·</sup>O<sub>2</sub><sup> –</sup> derived oxidants during I/R injury. Decreased GSH/GSS

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36

Al-Timari, A. A. A. K. "Binding determinants for some glutathione-dependent enzymes." Thesis, University of Essex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354003.

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37

Lewis, Alexander David. "Glutathione-dependent enzyme expression in drug resistance." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/19050.

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Glutathione and glutathione-dependent enzymes play a central role in the protection of cells from cytotoxic chemicals. In particular, reduced glutathione (GSH) and glutathione S- transferases (GST's) have been studied in relation to intrinsic and acquired resistance of tumours to cytotoxic drugs. There are however, other glutathione-dependent enzymes which may also be involved in drug resistance: these include glutathione perox-idase (GPX) and the enzymes, fglutamyltranspeptides (fGT), fglutamyl cysteinyl synthetase ('yGCS) and glutathione reductase (GRD). The latter enzymes are involved in th

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38

Meikle, Ian. "Glutathione S-transferases in the adrenal cortex." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/19139.

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Data available prior to this thesis had shown that, of all bovine organs examined, the adrenal cortex exhibited the second highest level of glutathione S-transferase (GST) expression behind the liver. This finding, along with increasing evidence implicating the importance of GST in endogenous detoxification processes, formed the basis for a further extensive investigation of the GST isoenzymes expressed by the adrenal cortex. Investigation of the GST isoenzymes expressed by a number of different bovine organs using affinity chromatography on S-hexylglutathione-Sepharose 6B (S-hexG-Ag) revealed

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39

Ahmad, Laziana. "Characterisation of glutathione transferase from Arabidopsis thaliana." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/17477/.

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Glutathione transferases (GSTs) are soluble enzymes with activity towards a wide range of xenobiotic and endogenous compounds. The Arabidopsis genome encoded 54 GSTs, which have been classified into eight classes including Tau and Phi. Members of these Tau and Phi clades are strongly upregulated in response to abiotic stresses such as xenobiotics and biotic stresses including pathogen attack. The most characterised activity of GSTs is the transfer of glutathione to an electrophilic centre to form a polar glutathionylated conjugate. However, increasing number of research demonstrated a non-cata

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40

REN, PEI. "Glutathione Reductase, Redox Homeostasis, and Mitochondrial Dysfunction." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1366643205.

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41

Dinescu, Adriana. "Modeling wild type and mutant glutathione synthetase." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc5556/.

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Glutathione syntethase (GS) is an enzyme that belongs to the ATP-grasp superfamily and catalyzes the second step in the biosynthesis of glutathione. GS has been purified and sequenced from a variety of biological sources; still, its exact mechanism is not fully understood. Four highly conserved residues were identified in the binding site of human GS. Additionally, the G-loop residues that close the active site during catalysis were found to be conserved. Since these residues are important for catalysis, their function was studied computationally by site-directed mutagenesis. Starting from the

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42

Hill, Alison Elspeth. "Regulation of glutathione S-transferases during stress." Thesis, University of Edinburgh, 1994. http://hdl.handle.net/1842/19846.

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Elevation of glutathione S-transferases (GST) in tumour cells can be responsible for resistance to a variety of chemotherapeutic agents. It has been hypothesised that GSTs may be induced as part of a stress response, similar to that of the prokaryotic adaptive response. To further this investigation I studied the induction of GSTs in a variety of permanent and transient stress models. A chlorambucil resistant CHO cell line which was known to express increased levels of Alpha-class GST was studied to determine the nature of the increase in protein. Northern and Southern blot analysis revealed a

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43

La, Pira Lucia. "Post-translational mechanisms regulating Glutathione Peroxidase 4." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424680.

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Glutathione peroxidase 4 (GPx4) is a selenocysteine-containing homolog of the vertebrate glutathione peroxidase family, peculiarly reducing membrane hydroperoxide by glutathione (GSH). GPx4 was first purified in 1982 as a ‘peroxidation inhibiting protein’, and is emerging to date, together with its substrate GSH, as a major determinant in regulating cell balance between proliferation and death. Recently, it emerged that GPx4 inactivation or GSH depletion in cells causes death by a novel subroutine relying on lipid peroxidation, named ferroptosis. Consistently, reverse genetics studies indicate

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44

Slavík, Jan. "Elektrochemické a matematické studium interakcí selenu s biologicky aktivními thioly." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2012. http://www.nusl.cz/ntk/nusl-219501.

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Proteins with thiol groups interact with metal ions in the human body. They maintain their homeostasis, participate in cell signaling, protect the cell against the effects of toxic metals and detoxify them. This work is focused on proteins with thiol groups glutathione and metallothionein and their effects on selenium. The method of study is electrochemical.

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45

Bangash, Sajid Ali Khan [Verfasser]. "Subcellular glutathione homeostasis and characterisation of glutathione transport across the plasma membrane in Arabidopsis thaliana / Sajid Ali Khan Bangash." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/1174670940/34.

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46

Lu, Weiya Douglas. "Photophysical consequences from interactions of glutathione S-transferases with the photodynamic sensitizer hypericin /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8638.

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47

Ingle, Brandall L. "The Mechanisms of Human Glutathione Synthetase and Related Non-Enyzmatic Catalysis." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc801927/.

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Human glutathione synthetase (hGS) is a homodimeric enzymes that catalyzes the second step in the biological synthesis of glutathione, a critical cellular antioxidant. The enzyme exhibits negative cooperativity towards the γ-glutamylcysteine (γ-GC) substrate. In this type of allosteric regulation, the binding of γ-GC at one active site significantly reduces substrate affinity at a second active site over 40 Å away. The presented work explores protein-protein interactions, substrate binding, and allosteric communication through investigation of three regions of hGS: the dimer interface, the S-l

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Daher, Boutaina. "Induction de la mort ferroptotique dans les cellules de cancer pancréatique : rôle essentiel de la cystéine et du transporteur xCT." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ6031.

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Les cellules cancéreuses possèdent un profil de prolifération et un métabolisme très accru nécessitant de sérieuses adaptations. Les tumeurs ont par conséquent, un besoin d’import de nutriments élevé mais aussi des défenses antioxydantes solides afin de combattre la toxicité des espèces réactives de l’oxygène (ROS). Les acides aminés, éléments clé de la structure et fonctionnalité des protéines, sont l’un des trois macronutriments essentiels pour la croissance tumorale. La cystéine est un acide aminé présentant une double fonction au sein de la cellule car en plus de son rôle protéogénique, la

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49

Han, Yi. "Functional analysis of glutathione and autophagy in response to oxidative stress." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112392/document.

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Le H2O2 est reconnu comme un signal dans l’activation des mécanismes de défense en réponse à divers stress, et son accumulation est donc régulée étroitement par le système antioxydant des plantes. Puisque la signalisation par le H2O2 peut être transmise par des processus thiol-dépendants, le statut du glutathion pourrait jouer un rôle important. Le rôle de ce composé en tant que molécule antioxydante est bien établi; cependant, son importance en tant que signal reste à élucider. Afin d’étudier cette question, ce travail a utilisé un mutant, cat2, ayant un défaut dans son métabolisme du H2O2 pe

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50

Roland, Aurélie. "Influence des phénomènes d'oxydation lors de l'élaboration des moûts sur la qualité aromatique des vins de Melon B. et de Sauvignon Blanc en Val de Loire." Thesis, Montpellier, SupAgro, 2010. http://www.theses.fr/2010NSAM0016/document.

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Abstract (sommario):

Afin de caractériser les moûts de Melon B. et de Sauvignon Blanc en composition et de modéliser leur profil d'oxydation, diverses méthodologies analytiques quantitatives ont été développées et validées. La quantification par dilution isotopique des précurseurs de thiols a nécessité la synthèse de molécules marquées qui ont également servies de traceurs lors d'études de filiation dans des milieux complexes. Ainsi, au cours de la fermentation alcoolique, nous avons pu démontrer que le S-3-(hexan-1-ol)-glutathion (G3MH) et la S-4-(4-méthylpentan-2-one)-glutathion (G4MMP) sont métabolisés par la l

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