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Letteratura scientifica selezionata sul tema "Hematopoiesis"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Hematopoiesis"

1

Sood, Raman, Milton English, Christiane Belele, et al. "Identification of Three Phases of Hematopoieisis in Zebrafish and Their Differential Requirements for Runx1 and Gata1 Functions." Blood 110, no. 11 (2007): 202. http://dx.doi.org/10.1182/blood.v110.11.202.202.

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Abstract Primitive hematopoiesis in the zebrafish takes place in the intermediate cell mass (ICM), while definitive hematopoiesis takes place in the kidney. Recently, a new transition site called caudal hematopoietic tissue (CHT), or posterior blood island (PBI) was identified. Using lineage tracing the hematopoietic cells originating from ICM were shown to transit through CHT and eventually populate kidney and thymus. However, the lineage relationship of the cells at these sites and the genetic control of early hematopoiesis in the zebrafish remain to be resolved. Transcription factors Gata1

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2

Wu, Jiang, Weiwei Zhang, Qian Ran, et al. "The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis." Stem Cells International 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/1540148.

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Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs). However, how BMSC differentiation affects hematopoiesis is poorly understood. In this review, we focus on the role of BMSC differentiation in hematopoiesis. We discussed the role of BMSCs and their progeny in hematopoiesis. We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy. M

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3

Gerosa, Rahel C., Steffen Boettcher, Larisa V. Kovtonyuk, et al. "CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis." Blood Advances 5, no. 23 (2021): 5002–15. http://dx.doi.org/10.1182/bloodadvances.2021005531.

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Abstract Hematopoiesis is maintained by hematopoietic stem and progenitor cells that are located in the bone marrow (BM) where they are embedded within a complex supportive microenvironment consisting of a multitude of various non-hematopoietic and hematopoietic cell types. The BM microenvironment not only regulates steady-state hematopoiesis by provision of growth factors, cytokines, and cell–cell contact but is also an emerging key player during the adaptation to infectious and inflammatory insults (emergency hematopoiesis). Through a combination of gene expression analyses in prospectively

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4

Ozbudak, Irem H., Konstantin Shilo, Sabine Hale, Nadine S. Aguilera, Jeffrey R. Galvin, and Teri J. Franks. "Alveolar Airspace and Pulmonary Artery Involvement by Extramedullary Hematopoiesis: A Unique Manifestation of Myelofibrosis." Archives of Pathology & Laboratory Medicine 132, no. 1 (2008): 99–103. http://dx.doi.org/10.5858/2008-132-99-aaapai.

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Abstract Pulmonary extramedullary hematopoiesis is a rare manifestation of myelofibrosis. We encountered a unique case of pulmonary extramedullary hematopoiesis occurring in a 59-year-old white man, where in addition to the typical foci of interstitial hematopoietic cells, a surgical lung biopsy showed airspace and arterial wall involvement. Airspace foci were associated with acute and organizing alveolar hemorrhage, while within arteries the hematopoietic elements had a striking predilection for the vascular intima. The hematopoietic foci included erythroid precursors, myeloid precursors, and

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5

Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.bloodjournal8682876.

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The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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6

Smith, Clayton. "Hematopoietic Stem Cells and Hematopoiesis." Cancer Control 10, no. 1 (2003): 9–16. http://dx.doi.org/10.1177/107327480301000103.

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Background The highly orchestrated process of blood cell development and homeostasis is termed “hematopoiesis.” Understanding the biology of hematopoietic stem cells as well as hematopoiesis is important to developing improved treatments for hematologic malignancies, congenital disorders, chemotherapy-related cytopenias, and blood and marrow transplants. Methods The author reviews the current state of the art regarding hematopoietic stem cells and hematopoiesis. Results Several new concepts, including stem cell plasticity, suggest the possibility that stem cells may have the ability to differe

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7

Wei, Chuijin, Pei Yu, and Lin Cheng. "Hematopoietic Reprogramming Entangles with Hematopoiesis." Trends in Cell Biology 30, no. 10 (2020): 752–63. http://dx.doi.org/10.1016/j.tcb.2020.07.006.

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8

Zon, LI. "Developmental biology of hematopoiesis." Blood 86, no. 8 (1995): 2876–91. http://dx.doi.org/10.1182/blood.v86.8.2876.2876.

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Abstract (sommario):

Abstract The cellular and environmental regulation of hematopoiesis has been generally conserved throughout vertebrate evolution, although subtle species differences exist. The factors that regulate hematopoietic stem cell homeostasis may closely resemble the inducers of embryonic patterning, rather than the factors that stimulate hematopoietic cell proliferation and differentiation. Comparative study of embryonic hematopoiesis in lower vertebrates can generate testable hypotheses that similar mechanisms occur during hematopoiesis in higher species.

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9

Testa, Ugo, Germana Castelli, and Elvira Pelosi. "CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC." Mediterranean Journal of Hematology and Infectious Diseases 14, no. 1 (2022): e2022069. http://dx.doi.org/10.4084/mjhid.2022.069.

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Abstract (sommario):

Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of clonal hematopoiesis. Clonal hematopoiesis of indeterminate potential (CHIP) is a term defining the clonal expansion of genetically variant hematopoietic cells bearing one or more gene mutations and/or structural variants (such as copy number alterations). CHIP increases exponentially with age and is associated with cancers, including hematolog

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10

Papa, Veronica, Luisa Marracino, Francesca Fortini, et al. "Translating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review." Journal of Clinical Medicine 9, no. 8 (2020): 2480. http://dx.doi.org/10.3390/jcm9082480.

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Abstract (sommario):

Some random mutations can confer a selective advantage to a hematopoietic stem cell. As a result, mutated hematopoietic stem cells can give rise to a significant proportion of mutated clones of blood cells. This event is known as “clonal hematopoiesis.” Clonal hematopoiesis is closely associated with age, and carriers show an increased risk of developing blood cancers. Clonal hematopoiesis of indeterminate potential is defined by the presence of clones carrying a mutation associated with a blood neoplasm without obvious hematological malignancies. Unexpectedly, in recent years, it has emerged

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Tesi sul tema "Hematopoiesis"

1

Javier, Jose Emmanuel F. "Increased TGF-beta Signaling Drives Different Hematopoietic Disease Outcomes following Stress Hematopoiesis." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1617109578665394.

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2

Lin, Xionghui. "Hematopoiesis in a Crustacean." Doctoral thesis, Uppsala universitet, Jämförande fysiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-121000.

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Hemocytes (blood cells) play an important role in the immune response in invertebrates, and thus the regulation of hemocyte homeostasis (hematopoiesis) is essential for the host survival against pathogens. Astakine 1, a homologue to vertebrate prokineticins, was first identified in the freshwater crayfish Pacifastacus leniusculus as a cytokine, and was found to be necessary for new hemocyte synthesis and release in vivo, and also to induce spreading and proliferation of Hematopoietic tissue cells (Hpt cells, precursor of hemocytes) in vitro. The work of this thesis is aimed to further our unde

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3

Benson, Eric Ashley. "Loss of SIMPL increases TNFalpha sensitivity during hematopoiesis." Connect to resource online, 2008. http://hdl.handle.net/1805/1851.

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Thesis (Ph. D.)--Indiana University, 2008.<br>Title from screen (viewed June 24, 2009). Department of Biochemistry and Molecular Biology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Maureen Harrington. Includes vita. Non-Latin script record. Includes bibliographical references (leaves 126-132).

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4

Urbieta, Maitee. "Regulatory T Cells and Hematopoiesis in Bone Marrow Transplantation." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/463.

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CD4+CD25+FoxP3+ regulatory T cells (Treg) possess the capacity to modulate both adaptive and innate immunity. Due to their suppressive nature, Treg cells have been studied and tested in a variety of scenarios in an attempt to ameliorate undesired immune responses. While graft versus host disease (GVHD) has in fact emerged as the first clinical application for human Treg cells (Riley et al. 2009), equally important are issues concerning hematopoietic engraftment and immune reconstitution. Currently, little is known about the effect(s) that regulatory T cells may exert outside the immune system

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Syrjänen, R. (Riikka). "TIM family molecules in hematopoiesis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204246.

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Abstract (sommario):

Abstract Hematopoietic cells, i.e., erythrocytes, platelets and white blood cells, differentiate from hematopoietic stem cells in a process that is similar in vertebrates. Hematopoiesis is regulated by molecules expressed by both the hematopoietic stem and progenitor cells and the surrounding microenvironments. Knowledge of these molecules is important since many of the genes involved in normal hematopoiesis are mutated in leukemia. Furthermore, this information can be utilized in more efficient isolation and expansion of hematopoietic cells in vitro. However, these molecules are not yet suffi

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Kuchenbauer, Florian. "MiRNAs in hematopoiesis and leukemogenesis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/16752.

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MicroRNAs (miRNAs) have been shown to play important roles in physiological as well as multiple malignant processes including acute myeloid leukemia (AML). In an effort to gain further insight into the role of miRNAs in AML, we have applied the Illumina massively parallel sequencing platform to carry out an in depth analysis of the miRNA transcriptome in a murine leukemia progression model, based on the engineered over-expression of the nucleoporin 98(NUP98)-homeobox HOXD13 fusion gene (ND13), followed by conversion into AML inducing cells upon transduction with the oncogenic collaborator Meis

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Hysenaj, Lisiena. "Alterations of hematopoiesis during brucellosis." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0251.

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La brucellose est une maladie qui se transmet de l’animal à l’homme. Elle est causée par la bactérie Brucella. Lors de ma thèse, j’ai montré que Brucella persiste dans les cellules de la moelle osseuse des animaux infectés. Ces observations sont très importantes car la moelle est un organe responsable de la génération des cellules du système immunitaires et c’est la principale niche des cellules souches hématopoïétiques. Au cours de ma thèse, j'ai montré que la protéine de la membrane externe 25 de Brucella (Omp25) est capable de lier au récepteur SLAMF1, une molécule exprimée par les cellules

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Bilotkach, Kateryna. "Quest for early hematopoietic stem cell precursors." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33056.

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The first transplantable hematopoietic stem cells (HSC) arise in the aorta-gonad mesonephros region (AGM) during early stages of embryo development. Specifically, ventral aspect of embryonic dorsal aorta (DA) contains HSC that upon transplantation into irradiated recipients can reconstitute all lineages of the haematopoietic system [Medvinsky et al. 1993; Muller and Medvinsky, 1994; Medvinsky and Dzierzak, 1996; Cumano et al., 1996; Tavian et al., 1996; Peault and Tavian, 2003; Taoudi and Medvinsky, 2007; Ivanovs et al., 2011, 2014]. The ventral aspect of DA bears so-called intra-aortic cell c

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9

Gronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.

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Abstract (sommario):

Bibliography: leaves 152-223. Experiments were designed to identify and purify human bone marrow stromal precursor cells by positive immunoselection, based on the cell surface expression of the VCAM-1 and STRO-1 antigens. The data presented demonstrates a hierarchy of bone cell development in vitro.

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10

Huang, Hsuan-Ting. "Epigenetic Regulation of Hematopoiesis in Zebrafish." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10175.

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The initiation of the hematopoietic program is orchestrated by key transcription factors that recruit chromatin regulators in order to activate or inhibit blood target gene expression. To generate a complete compendium of chromatin factors that establish the genetic code during developmental hematopoiesis, we conducted a large-scale reverse genetic screen targeting 425 chromatin factors in zebrafish and identified over 30 novel chromatin regulators that function at distinct steps of embryonic hematopoiesis. In vertebrates, developmental hematopoiesis occurs in two waves. During the first and p

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Libri sul tema "Hematopoiesis"

1

Gutti, Ravi Kumar. Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059.

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Baron, Margaret H. Developmental Hematopoiesis. Humana Press, 2004. http://dx.doi.org/10.1385/1592598269.

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3

Brown, Geoffrey, and Rhodri Ceredig. Cell determination during hematopoiesis. Nova Biomedical Books, 2009.

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4

Mihich, Enrico, and Donald Metcalf, eds. Normal and Malignant Hematopoiesis. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1927-0.

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Wickrema, Amittha, and Barbara Kee, eds. Molecular Basis of Hematopoiesis. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-85816-6.

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Dygai, A. M., and V. V. Zhdanov. Theory of Hematopoiesis Control. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-08584-5.

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1963-, Brown Geoffrey, and Ceredig Rhodri, eds. Cell determination during hematopoiesis. Nova Science Publishers, 2009.

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J, Fairbairn Leslie, and Testa Nydia G. 1938-, eds. Hematopoiesis and gene therapy. Kluwer Academic/Plenum Publishers, 1999.

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Amittha, Wickrema, and Kee Barbara Lynne 1966-, eds. Molecular basis of hematopoiesis. Springer, 2009.

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I, Zon Leonard, ed. Hematopoiesis: A developmental approach. Oxford University Press, 2001.

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Capitoli di libri sul tema "Hematopoiesis"

1

Rai, Geeta, Doli Das, Khushbu Priya, and Hiral Thacker. "Clinical Outcomes of Defective Hematopoiesis." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-7.

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Dahariya, Swati, Sanjeev Raghuwanshi, and Ravi Kumar Gutti. "Systems Biology Approaches Toward Understanding Human Long Noncoding RNA in Hematopoietic Cells." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-6.

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Kalle, Arunasree M., and Debasmita Naik. "Epigenetics of Hematopoiesis: Role of HATs and HDACs." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-5.

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Gautam, Dushyant Kumar, Anuradha Venkatakrishnan Chimata, Ravi Kumar Gutti, and Indira Paddibhatla. "Investigative Tools to Study Blood Cells: A Focus on Single Cell Isolation and Analysis." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-2.

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Singh, Anula Divyash, and Rasmita Samal. "Circulating Messengers of Blood and Their Clinical Applications." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-8.

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Subramani, Arun Kumar, Keyur Raval, and Ritu Raval. "Evaluation of Chitosan and Its Derivatives in Immunomodulating Blood Sentinel Cells." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-3.

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Prajapati, Akhilesh. "Hematopoiesis and Cancer Stem Cells: The Seed and the Soil Crosstalk." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-9.

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Wasnik, Samiksha, Lakshmi Manasay Chaturvedula, and Chaturvedula Tripura. "Proteoglycans and Glycosaminoglycans Regulating Functions of the Hematopoietic Stem Cell Niche." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-4.

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Chakraborty, Aparajita. "Unrevealing the Mechanism of Zebrafish Hematopoiesis: A Novel Approach." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-1.

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Choudhary, Anpreet, Rekha Sharma, Raghunath Manchala, et al. "Minimal Residual Disease (MRD) as a Prognostic Marker in Acute Myeloid Leukemia." In Hematopoiesis. Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003413059-11.

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Atti di convegni sul tema "Hematopoiesis"

1

Nelson, Darlene R., and Jay H. Ryu. "A Case Of Pleuropulmonary Extramedullary Hematopoiesis." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a6678.

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Grubač, Siniša, Marko Cincović, Jože Starič, Marinković Došenović, Biljana Delić-Vujanović, and Jasna Prodanov-Radulović. "The relationship of the metabolism of iron, organic matter and phlebotomy with the erythropoiesis of ruminants." In Zbornik radova 26. medunarodni kongres Mediteranske federacije za zdravlje i produkciju preživara - FeMeSPRum. Poljoprivredni fakultet Novi Sad, 2024. http://dx.doi.org/10.5937/femesprumns24012g.

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Erythropesis is the process of making red blood cells and it is related to numerous factors in the body. Iron is important because of its role in the process of making hemoglobin. In addition to the mentioned iron, it is an indirect indicator of inflammation and is regulated at the systemic and cellular level, so its lack speaks of the overall health status of individuals. Fe deficiency in the body takes place through three phases. In the first phase, there is emptying of tissue depots, but its total amount in the circulation increases, then follows the second phase or the phase of real defici

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Huang, Kuan-Lin, Mingchao Xie, Yige Wu, et al. "Abstract 3424: Genomic alterations in clonal hematopoiesis." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3424.

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Al-Qadi, M. O., M. Hunsucker, and J. Akulian. "Acute Myeloid Leukemia Arising from Pleural Extramedullary Hematopoiesis." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6702.

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Guang Zheng, Juping Chen, Lingru Wang, Ruimin Qin, Xi Zhang, and Kanni Gao. "Pathway enrichment analysis of Dang-gui for hematopoiesis." In 2015 12th International Conference on Fuzzy Systems and Knowledge Discovery (FSKD). IEEE, 2015. http://dx.doi.org/10.1109/fskd.2015.7382108.

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Djema, Walid, Frederic Mazenc, and Catherine Bonnet. "Lyapunov stability analysis of a model describing hematopoiesis." In 2015 European Control Conference (ECC). IEEE, 2015. http://dx.doi.org/10.1109/ecc.2015.7330947.

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Kim, Eunhee, Stephen S. Chung, Jae H. Park, et al. "Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-3140.

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Djema, Walid, Frederic Mazenc, and Catherine Bonnet. "Stability of immature cell dynamics in healthy and unhealthy hematopoiesis." In 2016 American Control Conference (ACC). IEEE, 2016. http://dx.doi.org/10.1109/acc.2016.7526631.

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Moore, Finola E., Virginie Esain, Riadh Lobbardi, Jessica S. Blackburn, Trista E. North, and David M. Langenau. "Abstract A33: Role for the tumor suppressor phf6 in hematopoiesis." In Abstracts: AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; September 20-23, 2014; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1557-3265.hemmal14-a33.

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Bhullar, Jasjeet, and Vincent E. Sollars. "Abstract 2964: YB-1 expression in early hematopoiesis and leukemic cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2964.

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Rapporti di organizzazioni sul tema "Hematopoiesis"

1

Taub, Floyd E., and Richard E. Weller. Proline-Rich Polypeptide 1 and GX-NH2: Molecular and Genetic Mechanisms of Hematopoiesis Regulation. Office of Scientific and Technical Information (OSTI), 2011. http://dx.doi.org/10.2172/1025686.

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Taub, Floyd, and Richard Weller. Proline-Rich Polypeptide 1 and GX-NH2: Molecular and Genetic Mechanisms of Hematopoiesis Regulation. Office of Scientific and Technical Information (OSTI), 2011. http://dx.doi.org/10.2172/1035210.

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3

Coltman, Charles A., and Jr. Clonal Hematopoiesis as a Marker of Genetic Damage Following Adjuvant Chemotherapy for Breast Cancer: Pilot Study to Evaluate Incidence. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada378125.

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4

Iwata, Mineo. Redefining the Hematopoietic Microenvironment. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada573826.

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Iwata, Mineo. Redefining the Hematopoietic Microenvironment. Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada583988.

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Felsher, Dean W. Nanoscale Proteomic Analysis of Oncoproteins in Hematopoietic Cancers. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada587676.

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Abel, Gregory, Haesook Kim, Thomas Walsh, Vincent Ho, and Robert Soiffer. Shared Care: Patient-Centered Management after Hematopoietic Cell Transplantation. Patient-Centered Outcomes Research Institute (PCORI), 2024. http://dx.doi.org/10.25302/09.2024.ihs.151133081.

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Dorshkind, Kenneth. Effects of Hematopoietic Stem Cell Age on CML Disease Progression. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada451341.

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Sytkowski, Arthur J. Development of Hematopoietic Growth Factors for Use in Military Personnel. Defense Technical Information Center, 1990. http://dx.doi.org/10.21236/ada238603.

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Sytkowski, Arthur J. Development of Hematopoietic Growth Factors for Use in Military Personnel. Defense Technical Information Center, 1991. http://dx.doi.org/10.21236/ada242475.

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