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Tesi sul tema "HIV (Viruses) Gene therapy"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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1

Fuller, Maria. "A gene transfer system derived from human immunodeficiency virus type 1 (HIV-1)." Title page, table of contents, list of abbreviations and epitome only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phf9669.pdf.

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2

Grzybowski, Brad. "A pseudotyped viral vector : hPIV3-HIV-1." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20932.

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3

Gelinas, Jean-Francois. "Enhancement of lentiviral vector production through alteration of virus-cell interactions." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:9921b8b4-e2b5-4eec-9efc-6036765c8d55.

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Abstract (sommario):

Gene therapy is the introduction or alteration of genetic material with the intention to treat disease. To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. Gene therapy vectors based on lentiviruses have many advantages, such as the ability to transduce non-dividing cells and to target specific cell types via pseudotyping. They have been successfully used in ex vivo clinical trials for several haematopoietic stem cell disorders. Lentiviral vectors, however, suffer from subst

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4

Elmén, Joacim. "Nucleic acid based therapeutic approaches /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-047-8/.

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5

Morin, Nicolas. "Expression of mutated HIV-1 Gag-Pol proteins and their effects on virus replication and infectiousness, implications for gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0015/MQ37152.pdf.

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6

Mackler, Randi Michelle. "Understanding Prototype Foamy Virus Integrase Site Selection, Activity, and Stability." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542306356468134.

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7

ALVES, Neyla Maria Pereira. "Influência de polimorfismos de base única (SNPs) no gene do receptor de vitamina D (VDR) na resposta à Terapia Antirretroviral (TARV) de pessoas vivendo com Vírus da Imunodeficiência Humana tipo 1 (HIV-1)." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/16120.

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Submitted by Haroudo Xavier Filho (haroudo.xavierfo@ufpe.br) on 2016-03-22T18:32:27Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação Neyla Alves_Versão digital.pdf: 1629049 bytes, checksum: aa72b7e3881142a178e5534aa4064d95 (MD5)<br>Made available in DSpace on 2016-03-22T18:32:27Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Dissertação Neyla Alves_Versão digital.pdf: 1629049 bytes, checksum: aa72b7e3881142a178e5534aa4064d95 (MD5) Previous issue date: 2015-03-02<br>CAPES<br>CNPq

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8

Costa, Matthew R. "FC Receptor-Mediated Activities of Env-Specific Monoclonal Antibodies Generated from Human Volunteers Receiving a DNA Prime-Protein Boost HIV Vaccine: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/866.

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Abstract (sommario):

Human immunodeficiency type 1 (HIV-1) is able to elicit broadly potent neutralizing antibodies in a very small subset of individuals only after several years’ infection and as a result, vaccines that elicit these types of antibodies have been difficult to design. The RV144 trial showed that a moderate protection is possible, which may correlate with antibody dependent cellular cytotoxicity (ADCC) activity. Previous studies in the Lu lab demonstrated that in an HIV-1 vaccine phase I trial, DP6-001, a polyvalent Env DNA prime-protein boost formulation, could elicit potent and broadly reactive, g

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9

Costa, Matthew R. "FC Receptor-Mediated Activities of Env-Specific Monoclonal Antibodies Generated from Human Volunteers Receiving a DNA Prime-Protein Boost HIV Vaccine: A Dissertation." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/866.

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Abstract (sommario):

Human immunodeficiency type 1 (HIV-1) is able to elicit broadly potent neutralizing antibodies in a very small subset of individuals only after several years’ infection and as a result, vaccines that elicit these types of antibodies have been difficult to design. The RV144 trial showed that a moderate protection is possible, which may correlate with antibody dependent cellular cytotoxicity (ADCC) activity. Previous studies in the Lu lab demonstrated that in an HIV-1 vaccine phase I trial, DP6-001, a polyvalent Env DNA prime-protein boost formulation, could elicit potent and broadly reactive, g

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10

Chen, Yuxin. "Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/760.

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Abstract (sommario):

Despite 30 years of intensive research，an effective human immunodeficiency virus (HIV) vaccine still remains elusive. The desirable immune response capable of providing protection against HIV acquisition is still not clear. The accumulating evidence learned from a recent vaccine efficacy correlate study not only confirmed the importance of antibody responses, but also highlighted potential protective functions of antibodies with a broad repertoire of HIV-1 epitope specificities and a wide range of different antiviral mechanisms. This necessitates a deep understanding of the complexity and dive

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11

Chen, Yuxin. "Characterization of Envelope-Specific Antibody Response Elicited by HIV-1 Vaccines: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/760.

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Abstract (sommario):

Despite 30 years of intensive research，an effective human immunodeficiency virus (HIV) vaccine still remains elusive. The desirable immune response capable of providing protection against HIV acquisition is still not clear. The accumulating evidence learned from a recent vaccine efficacy correlate study not only confirmed the importance of antibody responses, but also highlighted potential protective functions of antibodies with a broad repertoire of HIV-1 epitope specificities and a wide range of different antiviral mechanisms. This necessitates a deep understanding of the complexity and dive

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12

Singwi, Sanjeev. "HIV gene therapy using nucleases." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ46100.pdf.

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13

Saccardo, Paolo. "Development of artificial viruses for nanomedicine and gene therapy." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/287907.

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La convergencia de diversas disciplinas como la biotecnología, biología molecular e ingeniería genética en el desarrollo de vehículos terapéuticos a escala nanometrica para la entrega de moléculas terapeuticas, se plantea como una herramienta con un elevado potencial en el campo de la nanomedicina. El mayor reto de estos nanovehiculos es permitir una eficaz entrega de ácidos nucleicos, proteínas o incluso fármacos, con una elevada especificidad celular para poder así disminuir la dosis administrada y por eso reducir sus toxicidad. En el caso de los ácidos nucleicos, la especificidad de entreg

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14

Domingo, i. Espín Joan. "Development and characterization of artificial viruses for gene therapy." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/123204.

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Els riscos biològics associats a la teràpia gènica viral limiten el ple desenvolupament de vectors virals i plantegen importants problemes a la seva incorporació en assajos clínics. La teràpia gènica no viral representa una alternativa segura als virus naturals per al lliurament dirigida de gens a cèl·lules, tot i els baixos nivells d'expressió gènica obtinguts que és l’obstacle principal per la seva aplicació terapèutica. Els diferents tipus de vectors no virals que s'han desenvolupat fins ara, inclouen els basats en liposomes, dendrímers o proteïnes. Recentment, el concepte de "virus artific

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15

Zeicher, Marc. "Oncolytic viruses cancer therapy." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210439.

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Wild-type viruses with intrinsic oncolytic capacity in human includes DNA viruses like some autonomous parvoviruses and many RNA viruses. Recent advances in molecular biology have allowed the design of several genetically modified viruses, such as adenovirus and herpes simplex virus that specifically replicate in, and kill tumor cells. However, still several hurdles regarding clinical limitations and safety issues should be overcome before this mode of therapy can become of clinical relevance. It includes limited virus spread in tumor masses, stability of virus in the blood, trapping within th

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16

Hemmerling, Deborah Ruth. "Retroviral vectors for anti-HIV gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0004/NQ39538.pdf.

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17

Yager, Nicole Leanne. "Natural and therapy-induced immune control of HIV-1." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:e07f3022-4e14-4844-90ac-8d6f52a40a5a.

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The human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) response is important in the control of HIV-1 infection. Due to the virus having a high rate of mutation, immune pressure can select for variants that are no longer recognised by CTLs to dominate the viral quasispecies. This is similar to how antiretroviral resistance emerges. HIV-1 is therefore adapting to both human leukocyte antigen (HLA)-restricted immune responses and antiretroviral therapy. This thesis initially focused on the natural CTL response to an HLA-B*51-restricted epitope in integrase. This HLA class I

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18

McKnight, Aine Veronica. "Tropism and neutralization of human and simian immunodeficiency viruses." Thesis, Institute of Cancer Research (University Of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244796.

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19

Hotchkiss, Graham. "Towards ribozyme-mediated gene therapy of HIV-1 infections /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4007-X/.

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20

Tsafa, Effrosyni. "Broad strategies into engineering superior targeted gene therapy vectors derived from bacteriophage viruses." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/61571.

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Chemotherapy is the most commonly used treatment for cancer. While chemotherapeutic drugs such as doxorubicin provide cure in some cases, chemotherapy is toxic and has serious side-effects. Another disadvantage is that some types of cancer develop resistance to chemotherapy. Lowering the doses of these drugs will make them safer but would decrease their efficacy. A solution to this would be to combine low doses of these anticancer drugs with a safe anticancer approach. Cancer gene therapy is an alternative and promising approach of cancer treatment. In our group we are using the adeno-associat

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21

Kotsopoulou, Ekaterini. "The unusual HIV-1 codon bias as a tool for anti-HIV strategies." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312106.

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22

Kelly, Gloria Domingo. "Repression of Tat-transactived HIV-LTR directed gene expression by E1A 12S oncoprotein." Thesis, Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25227.

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23

Bockstael, Olivier. "Evaluation of gene transfer strategies using recombinant adeno-associated viruses for Parkinson's disease cell and gene therapy." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210010.

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La maladie de Parkinson se caractérise entre autres par une dégénérescence progressive des neurones dopaminergiques de la substance noire pars compacta (SNpc) qui innervent le striatum. Cette dégénération entraîne une baisse de la sécrétion de dopamine dans le striatum qui est responsable de la majorité des symptômes moteurs de la maladie de Parkinson. Plusieurs approches ont été étudiées pour le traitement de la maladie de Parkinson :i) restaurer une synthèse de dopamine dans le striatum par une greffe striatale de neurones dopaminergique ou par un transfert striatal de gènes impliqués dans l

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24

Maijgren, Steffensson Catharina. "Preclinical studies of ribozyme-mediated gene therapy for HIV-1 /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-883-1/.

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25

De, Silva Shamika Udayangi. "Chimeric adenoviruses as potential gene therapy vectors for HIV vaccination." Thesis, Royal Holloway, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435928.

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26

Chan, E. "Lentiviral gene therapy for HIV using TRIM-cyclophilin restriction factors." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1362851/.

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Lentiviral vector delivery of anti-HIV elements could provide the basis of alternative therapies against HIV, potentially providing long term protection after a single intervention. Some primate species have evolved restriction factors formed by the fusion of TRIM5α and Cyclophilin A (TRIM5Cyp) following retrotransposition of CypA cDNA into the TRIM5 gene, which provide potent resistance against certain lentiviruses. We have designed humanised versions of these proteins combining both TRIM5 and TRIM21 with CypA, and investigated their potential for use in gene therapy against HIV-1. Both TRIM5

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27

Landazuri, Natalia. "Enhanced gene transfer using polymer-complexed retrovirus vectors." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/20677.

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28

Wang, Xiaoxia. "Molecular studies on the action of APOBEC3G against HIV-1 and development of an APOBEC-based anti-HIV approach." American Society for Microbiology, 2011. http://hdl.handle.net/1993/23226.

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Currently, the HIV pandemic remains a major global health challenge. In order to effectively control and cure HIV-1 infection, it is necessary to perform greater research on host-HIV interactions and develop novel preventive and therapeutic approaches. The human cytidine deaminase APOBEC3G (A3G) is the first identified host restriction factor, which can serve as an initial line of defense against HIV-1 by inducing lethal mutations on proviral DNA and disrupting viral reverse transcription and integration. In order to better understand the action of A3G on HIV-1 replication, my study was focus

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29

Marais, Melanie. "A descriptive study to evaluate the effect of guidelines used by counsellors to improve adherence to antiretroviral therapy in the private sector." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&amp.

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30

Coulibaly, Tata Safiatou. "Double approche à la thérapie anti-tumorale à l'aide de vecteurs lentiviraux." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ087/document.

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Le traitement du cancer par thérapie génique nécessite d’une part des gènes suicides efficaces et, d’autre part, l’adressage spécifique de ces gènes aux cellules cancéreuses. J'ai d'abord caractérisé un nouveau gène suicide dérivé de la désoxycytidine kinase humaine (dCK) : le M36. Comparé à la dCK, le M36 permet une meilleure sensibilisation des certaines cellules cancéreuses aux traitements avec différents chimiothérapeutiques comme la gemcitabine et la cytarabine. Ces résultats sont particulièrement encourageants pour l'élimination des cellules cancéreuses résistantes à ces traitements du f

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31

Wiles, Karen Anna, and n/a. "Coxsackie and Adenovirus Receptor (CAR) expression is a potential limiting factor in adenoviral oncotheraphy." University of Otago. Dunedin School of Medicine, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070619.161353.

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Novel approaches to cancer treatment in the context of Gene Therapy have been gaining popularity as an alternative to conventional therapies which have proven to lack specificity, resulting in tumour cell resistance, tumour progression and mortality. As a consequence the use of adenoviruses has been widely developed not only as a replication deficient vector for gene therapy but also as a replication competent oncolytic agent designed to selectively target and kill tumour cells. Unfortunately their success in clinical application has been limited, and it has been suggested that a lack of the p

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32

De, Villiers Tania. "Characterisation of the HIV-1 subtype C Env gene and the expression of the Env protein from selected isolates in mammalian cells." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53329.

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Thesis (MSc)--Stellenbosch University, 2000.<br>ENGLISH ABSTRACT: At the end of 2002, human immunodeficiency virus (HIV) had infected 42 million people worldwide. The morbidity and mortality rate, as well as the epidemic proportions of the disease have led to concentrated scientific efforts to reveal the disease's pathogenesis and develop effective preventative and treatment measures. Advances have been made to inhibit viral replication by suppressing the virus' ability to replicate by developing antiretroviral treatments, although development of a save and effective vaccine is the only

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33

Turrell, Susan. "Development of Herpesvirus saimiri as a cancer gene therapy vector : production of 2 recombinant viruses." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534844.

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34

McKechnie, Victoria Margaret. "Variation in the NS5A gene of Hepatitis C Virus in response to interferon alpha therapy." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301364.

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35

Chono, Hideto. "Development of retroviral vector technology and application to HIV-1 gene therapy." Kyoto University, 2012. http://hdl.handle.net/2433/157729.

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36

Chen, Renxiang. "Studies of HIV-1 mutagenesis during drug therapy and the molecular determinants of HIV-1 variation." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1092663963.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 16.

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37

Mathew, Suneeth Fiona, and n/a. "Understanding genetic recoding in HIV-1 : the mechanism of -1 frameshifting." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081006.115352.

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The human immunodeficiency virus type 1 (HIV-1) uses a mechanism of genetic recoding known as programmed ribosomal frameshifting to translate the proteins encoded by the pol gene. The pol gene overlaps the preceding gag gene in the -1 reading frame relative to gag. It contains neither a start codon nor an internal ribosome entry site (IRES) to initiate translation of its proteins. Rather the host ribosomes are forced to pause due to tension placed on the mRNA when they encounter a specific secondary structural element in the mRNA. This tension is relieved by disruption of the contacts between

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38

Kambole, Mercy Mulenga. "The attitudes of physiotherapists in Gaborone and Ramotswa, Botswana, towards treating people living with HIV/AIDS." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_7700_1256285107.

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<p>Physiotherapists are increasingly treating peole living with HIV/AIDS. However, there is little information which has been reported on their attitudes in providing treatment to people with HIV/AIDS or what facilitates positive attitudes. The aim of this study was to determine attitudes of physiotherapists towards treating people living with HIV/AIDS in Botswana.</p>

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39

Medina, Maria Fe C. "Strategies for isolation and expression of ribozymes for use in HIV gene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/NQ49949.pdf.

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40

Adams, Gregor Barr. "The development of a haemopoietic stem cell gene therapy for HIV-1 infection." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325184.

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41

Kim, Vic Narry. "Analysis of components of HIV in the development of new gene transfer systems." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389043.

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42

Huang, Kuan-Hsiang Gary. "The impact of host and therapy mediated selection on HIV-1 evolution." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:b49d0d79-75c9-4314-92ae-1f1789ac7d42.

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Abstract (sommario):

The Human immunodeficiency virus (HIV) pandemic has resulted in a heavy global disease burden, and clinically causes Acquired Immuno-Deficiency Syndrome (AIDS). The development of highly active antiretroviral therapy (HAART) has achieved remarkable control of the rapidly evolving HIV. However, HIV remains neither curable nor preventable by vaccine, and in the developing regions worst affected by HIV, HAART remains inaccessible to most patients. Furthermore, the change in both immunology and viral evolution during chronic HIV infection and its relation to AIDS pathogenesis remains unknown. Foll

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43

Dias, Florencio Leite Gabriella. "Recombinant Adeno-Associated Viruses : process development and gene transfer application for muscular dystrophy." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLV051/document.

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L'intérêt de l’utilisation des vecteurs viraux comme le Adeno-Associated Virus recombinant (rAAV) dans la recherche pour le traitement des maladies génétiques a conduit à une évolution rapide des méthodes de production d'AAV au cours des deux dernières décennies (Ayuso et al., 2010). Leur large biodisponibilité in vivo et leur efficacité à long terme dans les tissus postmitotiques en font de bons candidats pour de nombreuses applications de transfert de gènes. En plus, la spécificité du traitement peut être augmentée lorsque le sérotype correct est choisi pour cibler un tissu spécifique. Parmi

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44

Bazan, Peregrino Miriam. "Combining regulatory angiogenic gene therapy and virotherapy for the treatment of breast cancer." Thesis, University of Oxford, 2007. http://ora.ox.ac.uk/objects/uuid:550c6509-a52e-4770-8bff-dae2071c3ade.

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This thesis describes the design of a virotherapy strategy capable of destroying both breast cancer vasculature and tumour cells, using an oncolytic adenovirus expressing angiogenesis-regulating proteins. Five oncolytic adenoviruses were compared to identify the best virotherapy agent for breast cancer, including measurement of cytotoxicity in vitro, and replication, intra-tumoural spread and anticancer efficacy in vivo. The viruses tested were Ad-dl922-947 (targets G1-S checkpoint defects); Ad-Onyx-015 and Ad-Onyx-017 (target p53/mRNA nuclear export defects); Ad-vKH1 (targets Wnt pathway defe

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45

Ui, Masahiro. "Protection of Macaques Vaccinated with Gene-Deleted HIV-1/SIVmac Chimeric Viruses(SHIVs)Having HIV-1 Env against a Gene-Intact SHIV : a Potential of Live-Attenuated Vaccines for AIDS." Kyoto University, 2000. http://hdl.handle.net/2433/181021.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第8455号<br>人博第85号<br>11||153(吉田南総合図書館)<br>新制||人||21(附属図書館)<br>UT51-2000-F359<br>京都大学大学院人間・環境学研究科人間・環境学専攻<br>(主査)教授速水正憲, 教授池永満生, 教授松井正文<br>学位規則第4条第1項該当

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46

Mustafa, Farah. "HIV-1 Sequences in the Establishment of Chronic Virus Producers: a Thesis." eScholarship@UMMS, 1993. https://escholarship.umassmed.edu/gsbs_diss/38.

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Human immunodeficiency virus type 1 (HIV-1) infections have different patterns of expression in different T-cell lines. HIV-1 encodes regulatory as well as structural genes. The role of HIV-1 regulatory gene expression in determining different patterns of infection was explored in four T-cell lines: C8166, H9, A3.01, and Jurkat. The hypothesis being tested was that differences in the expression of regulatory genes would determine differences in the kinetics of infection. To study patterns of regulatory and structural gene expression, RNA was isolated from cultures infected with HIV-1-NL4-3 (NL

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47

Lipinski, Daniel Mark. "Neuroprotection of cone photoreceptors in retinitis pigmentosa." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:aee440bc-f990-4216-9d43-63902ff0fc52.

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Retinitis pigmentosa (RP) is a genetically and phenotypically heterogeneous condition that affects approximately 1 in 4000 individuals worldwide. The most common presentation of RP is a rod-cone dystrophy, where the degeneration of cone photoreceptors occurs secondary to advanced rod loss, leading to a significant decline in central vision and a corresponding reduction in patient quality of life. The mechanisms underlying secondary cone loss are poorly understood, particularly in disorders where the gene defect is unknown or manifest only in rod photoreceptors. Consequently, the thesis present

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48

Thobias, Anna. "Exploration of factors associated with poor adherence among patients receiving antiretroviral therapy at Katutura State Hospital Communicable Disease Clinic in Khomas region, Namibia /." Online access, 2008. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_2455_1273775841.pdf.

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49

Arteaga, H. Jose. "Strategies of gene and immune therapy for tumors and viral diseases /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-528-x.

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50

Tsang, Shirley Xiaoman. "TATA-dependent repression of human immunodeficiency virus Type-1 transcription by the Adenovirus E1A 243R oncoprotein." Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/25325.

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