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Letteratura scientifica selezionata sul tema "HMLE"

Autore: Grafiati

Pubblicato: 10 dicembre 2022

Ultima modifica: 29 gennaio 2023

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Articoli di riviste sul tema "HMLE"

1

Chandrashekaran, Murali, e Beth A. Walker. "Meta-Analysis with Heteroscedastic Effects". Journal of Marketing Research 30, n. 2 (maggio 1993): 246–55. http://dx.doi.org/10.1177/002224379303000209.

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To enhance the utility of meta-analysis as an integrative tool for marketing research, heteroscedastic MLE (HMLE), a maximum-likelihood-based estimation procedure, is proposed as a method that overcomes heteroscedasticity, a problem known to impair OLS estimates and threaten the validity of meta-analytic findings. The results of a Monté Carlo simulation experiment reveal that, under a wide range of heteroscedastic conditions, HMLE is more efficient and powerful than OLS and achieves these performance advantages without inflating type I error. Further, the relative performance of HMLE increases as heteroscedasticity becomes more severe. An empirical analysis of a meta-analytic dataset in marketing confirmed and extended these findings by illustrating how the enhanced efficiency and power of HMLE improve the ability to detect moderator variables and by demonstrating how the theoretical generalizations emerging from a meta-analysis are affected by the choice of the analytic procedure.

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2

Zhan, Chesheng, Jian Han, Lei Zou, Fubao Sun e Tiejun Wang. "Heteroscedastic and symmetric efficiency for hydrological model evaluation criteria". Hydrology Research 50, n. 5 (20 giugno 2019): 1189–201. http://dx.doi.org/10.2166/nh.2019.121.

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Abstract Evaluation criteria play a key role in assessing the performances of hydrological models. Most previous criteria are based on the standard least square method, which assumes model residuals to be homoscedastic and is, therefore, not suitable for assessing cases with heteroscedastic residuals. Here, we compared a heteroscedastic and symmetric efficiency (HSE) criterion with the Nash–Sutcliffe efficiency (NSE) and the heteroscedastic maximum-likelihood estimator (HMLE) by running a monthly water balance model with four parameters (i.e., the abcd model) in 138 basins located in the continental United States derived from the Model Parameter Estimation Experiment dataset. The results show that compared to the NSE, the HSE and HMLE are both more effective for stabilizing variance and producing more uniform performances with flow magnitude, and the latter is slightly more effective than the former on stabilizing the residual heteroscedasticity, with the aid of an additional parameter.

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3

Reche-Soto, Pedro, Daniel Rojas-Valverde, Alejandro Bastida-Castillo, Carlos D. Gómez-Carmona, Markel Rico-González, Luiz H. Palucci Vieira, Luca Paolo Ardigò e José Pino-Ortega. "Using Ultra-Wide Band to Analyze Soccer Performance through Load Indicators during a Full Season: A Comparison between Starters and Non-Starters". Applied Sciences 12, n. 24 (10 dicembre 2022): 12675. http://dx.doi.org/10.3390/app122412675.

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The objectives of this study are: (1) to compare match load demands through load indicators between starters and substitutes, and (2) analyze the degree of correlation in the variables analyzed in this investigation. Twenty-two semi-professional soccer players were analyzed during a full season’s 38 official matches. Participants were assigned to two different groups according to their participation in the game: (a) starting-up players (≥90 min played) vs. substitute players (≥45 min played in the second half). Statistical analysis was performed by using Mann–Whitney U test to conduct pairwise comparison and Spearman correlation to demands correlation in each group. Significant differences in both absolute and relative variables in player load (P, p < 0.01; p < 0.01), metabolic power (MP, p < 0.01; p = 0.15), equivalent distance index (EDI, p = 0.87; p < 0.01), dynamic stress load (DSI, p < 0.01; p = 0.977), energy expenditure (EE, p < 0.01; p < 0.01), high metabolic load events (HMLE, p < 0.01; p < 0.01), and high metabolic load distance (HMLD, p < 0.01; p = 0.09). Overall, high direct correlations in the starting-up group in absolute and relative demands of PL, PM, HMLD, EE, and DSL were found, as well as high inverse correlation in the substitute group in all variables, excluding DSL and HMLD. In conclusion, the absolute differences found suggested a different training load management during training sessions.

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4

Libring, Sarah, Aparna Shinde, Miad Boodaghidizaji, Alexandra Plummer, Arezoo Ardekani, Michael Wendt e Luis Solorio. "4168 Understanding ECM-Based Drug Resistivity in Breast Cancer". Journal of Clinical and Translational Science 4, s1 (giugno 2020): 113–14. http://dx.doi.org/10.1017/cts.2020.346.

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OBJECTIVES/GOALS: Cell-cell (CC) and cell-matrix interactions (CM) are known to affect drug sensitivity of cancer cells, but are not effectively recapitulated using 2D platforms. This research aims to determine how cell and matrix interactions confer drug resistivity in 3 distinct culturing models: 2D (no CM/limited CC), 3D spheroids (CC) and 3D fibronectin (both). METHODS/STUDY POPULATION: We examined four breast cancer cell types. The cells were derived from a nonmetastatic primary tumor (HMLE-E2) or overt bone-metastasis (BM). Transglutaminase 2 (TGM2), a matrix crosslinking protein, is overexpressed in metastatic bone tumors and may play a key role in matrix-conferred drug resistivity. In a gain-of-function model, TGM2 was upregulated in HMLE-E2 cells and compared to shTGM2 knockdown BM cells. Growth rates were analyzed using metabolic activity over 8 days, and drug sensitivity to Neratinib (0-1000 nM) was analyzed via cell titer. To account for the different transport properties of the 3 distinct culture environments, we developed a mathematical model for each condition, allowing us to normalize the drug sensitivity results across models to effectively compare true biological resistivity. RESULTS/ANTICIPATED RESULTS: We observed that increased cellular levels of TGM2 significantly increase the growth rate and drug resistivity of cells on fibronectin matrices. Interestingly, in 2D cultures, TGM2 expression was correlated with higher Neratinib resistivity but did not affect growth rates. In spheroid models without a significant matrix component, that rely solely on cell-cell junctions, high levels of TGM2 were correlated with lower survival rates. Lower levels of TGM2 are correlated with a more epithelial phenotype, and using our mathematical model we have identified significant transport differences between high and low TGM2 spheroids. We theorize that the low TGM2 spheroids have denser packing, which lowers the rate of diffusion and, thus reduces the effective concentration of the drug to the majority of the cells. DISCUSSION/SIGNIFICANCE OF IMPACT: Our studies indicate that the cellular response to drugs can be altered by changes in both transport properties of the tissue and the CM interactions. By systematically investigating the effects of CC interactions and CM interactions, we can use mathematical models to delineate physical means of drug resistivity from a biologically driven resistance.

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5

Weiss, Kerstin, e Robert T. Simpson. "High-Resolution Structural Analysis of Chromatin at Specific Loci: Saccharomyces cerevisiae Silent Mating Type Locus HMLα". Molecular and Cellular Biology 18, n. 9 (1 settembre 1998): 5392–403. http://dx.doi.org/10.1128/mcb.18.9.5392.

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ABSTRACT Genetic studies have suggested that chromatin structure is involved in repression of the silent mating type loci in Saccharomyces cerevisiae. Chromatin mapping at nucleotide resolution of the transcriptionally silent HMLα and the activeMATα shows that unique organized chromatin structure characterizes the silent state of HMLα. Precisely positioned nucleosomes abutting the silencers extend over the α1 and α2 coding regions. The HO endonuclease recognition site, nuclease hypersensitive at MATα, is protected atHMLα. Although two precisely positioned nucleosomes incorporate transcription start sites at HMLα, the promoter region of the α1 and α2 genes is nucleosome free and more nuclease sensitive in the repressed than in the transcribed locus. Mutations in genes essential for HML silencing disrupt the nucleosome array near HML-I but not in the vicinity of HML-E, which is closer to the telomere of chromosome III. At the promoter and the HO site, the structure of HMLα in Sir protein and histone H4 N-terminal deletion mutants is identical to that of the transcriptionally active MATα. The discontinuous chromatin structure of HMLα contrasts with the continuous array of nucleosomes found at repressed a-cell-specific genes and the recombination enhancer. Punctuation at HMLα may be necessary for higher-order structure or karyoskeleton interactions. The unique chromatin architecture of HMLα may relate to the combined requirements of transcriptional repression and recombinational competence.

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6

Bystricky, Kerstin, Haico Van Attikum, Maria-Dolores Montiel, Vincent Dion, Lutz Gehlen e Susan M. Gasser. "Regulation of Nuclear Positioning and Dynamics of the Silent Mating Type Loci by the Yeast Ku70/Ku80 Complex". Molecular and Cellular Biology 29, n. 3 (1 dicembre 2008): 835–48. http://dx.doi.org/10.1128/mcb.01009-08.

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ABSTRACT We have examined the hypothesis that the highly selective recombination of an active mating type locus (MAT) with either HMLα or HMR a is facilitated by the spatial positioning of relevant sequences within the budding yeast (Saccharomyces cerevisiae) nucleus. However, both position relative to the nuclear envelope (NE) and the subnuclear mobility of fluorescently tagged MAT, HML, or HMR loci are largely identical in haploid a and α cells. Irrespective of mating type, the expressed MAT locus is highly mobile within the nuclear lumen, while silent loci move less and are found preferentially near the NE. The perinuclear positions of HMR and HML are strongly compromised in strains lacking the Silent information regulator, Sir4. However, HMLα, unlike HMR a and most telomeres, shows increased NE association in a strain lacking yeast Ku70 (yKu70). Intriguingly, we find that the yKu complex is associated with HML and HMR sequences in a mating-type-specific manner. Its abundance decreases at the HMLα donor locus and increases transiently at MAT a following DSB induction. Our data suggest that mating-type-specific binding of yKu to HMLα creates a local chromatin structure competent for recombination, which cooperates with the recombination enhancer to direct donor choice for gene conversion of the MAT a locus.

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7

Li, Xiu Juan, Zhao Jun Ren, Jin Hai Tang e Qiao Yu. "Exosomal MicroRNA MiR-1246 Promotes Cell Proliferation, Invasion and Drug Resistance by Targeting CCNG2 in Breast Cancer". Cellular Physiology and Biochemistry 44, n. 5 (2017): 1741–48. http://dx.doi.org/10.1159/000485780.

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Background/Aims: Treatment of breast cancer remains a clinical challenge. This study aims to validate exosomal microRNA-1246 (miR-1246) as a serum biomarker for breast cancer and understand the underlying mechanism in breast cancer progression. Methods: The expression levels of endogenous and exosomal miRNAs were examined by real time PCR, and the expression level of the target protein was detected by western blot. Scanning electron and confocal microscopy were used to characterize exosomes and to study their uptake and transfer. Luciferase reporter plasmids and its mutant were used to confirm direct targeting. Furthermore, the functional significance of exosomal miR-1246 was estimated by invasion assay and cell viability assay. Results: In this study, we demonstrate that exosomes carrying microRNA can be transferred among different cell lines through direct uptake. miR-1246 is highly expressed in metastatic breast cancer MDA-MB-231 cells compared to non-metastatic breast cancer cells or non-malignant breast cells. Moreover, miR-1246 can suppress the expression level of its target gene, Cyclin-G2 (CCNG2), indicating its functional significance. Finally, treatment with exosomes derived from MDA-MB-231 cells could enhance the viability, migration and chemotherapy resistance of non-malignant HMLE cells. Conclusions: Together, our results support an important role of exosomes and exosomal miRNAs in regulating breast tumor progression, which highlights their potential for applications in miRNA-based therapeutics.

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Singh, Vishal, Keshav Kumar Jha, Jyothsna K. M, Rekha V. Kumar, Varun Raghunathan e Ramray Bhat. "Iduronate-2-Sulfatase-Regulated Dermatan Sulfate Levels Potentiate the Invasion of Breast Cancer Epithelia through Collagen Matrix". Journal of Clinical Medicine 8, n. 10 (30 settembre 2019): 1562. http://dx.doi.org/10.3390/jcm8101562.

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Cancer epithelia show elevation in levels of sulfated proteoglycans including dermatan sulfates (DS). The effect of increased DS on cancer cell behavior is still unclear. We hypothesized that decreased expression of the enzyme Iduronate-2-sulfatase (IDS) can lead to increased DS levels, which would enhance the invasion of cancer cells. Breast cancer sections shows depleted IDS levels in tumor epithelia, when compared with adjacent untransformed breast tissues. IDS signals showed a progressive decrease in the non-transformed HMLE, transformed but non-invasive MCF-7 and transformed and invasive MDA-MB-231 cells, respectively, when cultured on Type 1 collagen scaffolds. DS levels measured by ELISA increased in an inverse-association with IDS levels. Knockdown of IDS in MCF-7 epithelia also increased the levels of DS. MCF-7 cells with depleted IDS expression, when imaged using two photon-excited fluorescence and second harmonic generation microscopy, exhibited a mesenchymal morphology with multiple cytoplasmic projections compared with epithelioid control cells, interacted with their surrounding matrix, and showed increased invasion through Type 1 collagen matrices. Both these traits were phenocopied when control MCF-7 cells were cultivated on Type 1 collagen gels polymerized in the presence of DS. In monolayer cultures, DS had no effect on MCF-7 migration. In the context of our demonstration that DS enhances the elastic modulus of Type 1 collagen gels, we propose that a decrease of IDS expression leads to accumulation within cancer epithelia of DS: the latter remodels the collagen around cancer cells leading to changes in cell shape and invasiveness through fibrillar matrix milieu.

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Luo, Haiqing, Chih-Yu Chen, Xiangyong Li, Xin Zhang, Chien-Wen Su, Yinghua Liu, Tinglan Cao, Lei Hao, Meng Wang e Jing X. Kang. "Increased Lipogenesis is Critical for Self-Renewal and Growth of Breast Cancer Stem Cells: Impact of Omega-3 Fatty Acids". Stem Cells 39, n. 12 (17 settembre 2021): 1660–70. http://dx.doi.org/10.1002/stem.3452.

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Abstract Aberrant lipid metabolism has recently been recognized as a new hallmark of malignancy, but the characteristics of fatty acid metabolism in breast cancer stem cells (BCSC) and potential interventions targeting this pathway remain to be addressed. Here, by using the in vitro BCSC models, mammosphere-derived MCF-7 cells and HMLE-Twist-ER cells, we found that the cells with stem cell-like properties exhibited a very distinct profile of fatty acid metabolism compared with that of their parental cancer cells, characterized by increased lipogenesis, especially the activity of stearoyl-CoA desaturase 1 (SCD1) responsible for the production of monounsaturated fatty acids, and augmented synthesis and utilization of the omega-6 arachidonic acid (AA). Suppression of SCD1 activity by either enzyme inhibitors or small interfering RNA (siRNA) knockdown strikingly limited self-renewal and growth of the BCSC, suggesting a key role for SCD1 in BCSC proliferation. Furthermore, elevated levels of SCD1 and other lipogenic enzymes were observed in human breast cancer tissues relative to the noncancer tissues from the same patients and correlated with the pathological grades. Interestingly, treatment of BCSC with omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid, effectively downregulated the expression of the lipogenic enzymes and markedly suppressed BCSC self-renewal and growth. Dietary supplementation of nude mice bearing BCSC-derived tumors with omega-3 fatty acids also significantly reduced their tumor load. These findings have demonstrated that increased lipogenesis is critical for self-renewal and growth of BCSC, and that omega-3 fatty acids are effective in targeting this pathway to exert their anticancer effect.

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Zhao, Yingcheng, Xichuan Liu, Kang Pu, Jin Ye e Minghao Xian. "Research on the Method of Rainfall Field Retrieval Based on the Combination of Earth–Space Links and Horizontal Microwave Links". Remote Sensing 14, n. 9 (6 maggio 2022): 2220. http://dx.doi.org/10.3390/rs14092220.

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High-precision retrieval of rainfall over large areas is of great importance for the research of atmospheric detection and the social life. With the rapid development of communication satellite constellations and 5G communication networks, the use of widely distributed networks of earth–space links (ESLs) and horizontal microwave links (HMLs) to retrieve rainfall over large areas has great potential for obtaining high-precision rainfall fields and complementing traditional instruments of rainfall measurement. In this paper, we carry out the research of combining multiple ESLs with HMLs to retrieve rainfall fields. Firstly, a rainfall detection network for retrieving rainfall fields is built based on the atmospheric propagation model of ESL and HML. Then, the ordinary Kriging interpolation (OK) and radial basis function (RBF) neural network are applied to the reconstruction of rainfall fields. Finally, the performance of the joint network of ESLs and HMLs to retrieve rainfall fields in the area is validated. The results show that the joint network of ESLs and HMLs based on OK algorithm and RBF neural network is capable of retrieving the distribution of rain rates in different rain cells with high accuracy, and the root mean square error (RMSE) of retrieving the rain rates of real rainfall fields is lower than 0.56 mm/h, and the correlation coefficient (CC) is higher than 0.996. In addition, the CC for retrieving stratiform rainfall and convective rainfall by the joint network of ESLs and HMLs is higher than 0.949, indicating that the characteristics of the two different types of rainfall events can be accurately monitored.

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Più fonti

Tesi sul tema "HMLE"

1

Bronner, Anna [Verfasser], e Karl [Akademischer Betreuer] Sotlar. "Analysen von BRCA1 und BRMS1 in durch TWIST1 induzierbarem EMT-Modell in HMLE-Zellen / Anna Bronner ; Betreuer: Karl Sotlar". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221960598/34.

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Salman, Mohammed, e Michael Afrem. "Produktionseffektivisering inom HMLV-miljöer". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-28499.

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Flertal små företag med stor produktflora i små volymer har uttryckt en vilja för att implementera Lean-verktyg i deras företag och ofta har det inte genererat de goda resultat de förväntat sig. För att dessa företag ska bli framgångsrika i sitt implementerande av Lean gäller det att de utvärderar vilka verktyg som gynnar företaget och vilka som inte medför förbättring. Problematiken som uppstår i detta är kulturella förändringar där det är vanligt att arbetare inte visar motivation eller intresse för att förändra sin tidigare arbetsrutin och här har ledningen stort ansvar att motivera arbetarna till att vara delaktiga och välkomna förbättringar. För att kunna undersöka detta utförligt har en fallstudie och litteraturstudie utförts för att studera: 1) Hur HMLV-företag bör gå tillväga för att arbeta med Lean, 2) vilka Lean-principer som går att implementera i HMLV-miljön och slutligen 3) hur man övertygar medarbetarna att ändra sitt befintliga arbetssätt till en mer standardiserad arbetsform. Resultat från litteraturstudien visar hur viktigt det är att studera vilka verktyg som passar in i ett specifikt företag och att man ska samla information om hur man ska gå tillväga innan man beslutar sig för något. Litteraturstudien visar även att ledningen har en stor roll i att övertyga medarbetarna till att engagera sig i förändringsarbetet. Resultat från fallstudien styrker litteraturstudiens påståenden om hur viktigt det är att studera vilka verktyg som passar in i ett specifikt företag och hur dessa företag bör gå tillväga. Fallstudien styrker också påståendet att ledningen har en stor roll i att motivera arbetarna men även att arbetarna i sin tur måste ta sitt ansvar och engagera sig.

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Mohammadpour, Violet, e Sebastian Häll. "Supporting the development of a HMLV production cell". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-54532.

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Production system development is challenging for manufacturing companies, and development of HMLV production cells entails additional challenges. Thus, the aim of this study is to support the development of a HMLV production cell, and the following research questions were asked: RQ1: What are the challenges of developing a HMLV production cell? RQ2: What are the critical factors to consider when developing a HMLV production cell? RQ3: How can the development of a HMLV production cell be supported? A literature review in combination with a case study were performed to fulfill the aim and answer the research questions. The literature review was conducted to gain knowledge from previous studies, whilst the case study was performed to complement the theoretical findings. The selected case is the development of a HMLV production cell in the department of engine machining at Scania, which is planned to perform production activities for various departments of Scania. The primary data was collected through observations and interviews. The identified challenges of developing a HMLV production cell were production planning, utilization of equipment, product quality and material flow. The identified critical factors to consider when developing a HMLV production cell were production flexibility, production competence, production technology, pilot production, manufacturing strategy, order management system and standardization. The identified challenges of developing a HMLV production cell and the critical factors to consider when developing a HMLV production cell can support manufacturing companies by informing what challenges to expect prior to developing a HMLV production cell, and what critical factors can mitigate these challenges. Two ways of supporting the development of a HMLV production cell are recommended to Scania: creating a structured order management system and performing a pilot production for the milling operation of the core box reparation process. During this study, it was discovered that different HMLV production cells have different capabilities, challenges, and therefore also different critical factors. As such, recommendation for further research is to investigate how the development of different types of HMLV production cells can be supported by using a multiple case study research design, and to compare the challenges and critical factors for the development for the different types of HMLV production cells.

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Andersson, Martina. "Processeffektivisering i HMLV-miljö med hjälp av Lean". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-44037.

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Syfte och frågeställningar: Syftet med examensarbetet är - att genom att kartlägga nuvarande process och identifiera slöserier i den - undersöka om företag inom HMLV-miljöer kan bli mer effektiva genom att använda sig av verktyg och principer inom lean produktion. Utifrån syftet formulerades och besvarades följande två frågeställningar: 1) Har Lean betydande inverkan även vid produktion av lägre volymer? 2) Hur kan företag inom HMLV - produktion som tillverkar mot order bli mer effektiva och öka kvaliteten med implementering av Lean? Metod och genomförande: En fallstudie har utförts på ett litet HMLV-företag som tillverkar produkter mot kundorder. Kvalitativ som kvantitativ data har främst inhämtats genom observationer, mätningar, semistrukturerade och ostrukturerade intervjuer samt genom analysering av företagsdokument i form av ordrar och beställningshistorik. För att knyta an fallstudien till teorin har en litteraturstudie genomförts i vilken information har inhämtats från såväl böcker som vetenskapliga artiklar. Resultat: Fallstudien visar efter en kartläggning av processflödet av en artikel att företaget på vilket studien utfördes idag inte jobbar med Lean i någon större utsträckning. Kartläggningen visar att det förekommer flertalet slöserier i form av väntan mellan processer, onödiga rörelser mellan stationer samt att artikeln rör sig ojämnt genom de olika processerna i flödet varför det varit en komplex uppgift att kartlägga densamma. Slutsatser: De slutsatser som kan dras från fallstudien i relation till den teoretiska referensramen är att företag inom HMLV-produktion kan använda sig av vissa leanverktyg för att bli mer effektiva medan andra verktyg är sämre lämpade i den nämnda miljön. Vidare kan några av de 14 principerna anammas för att företaget både ska bli mer effektiva men även för att öka kvaliteten på sina produkter. Nyckelord: Lean, logistic, high-mix-low-volume (HMLV), production improvement.

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5

Andersson, Jonas, e Patrik Hedlund. "Undersökning om handhållna laserskannrar vid detaljmätning : En jämförelse mellan multistationen Leica Nova MS50 och den handhållna laserskannern FARO Freestyle X". Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22200.

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Terrestra laserskannrar har varit vanligt förekommande i geodetiska mätningar i över 10 år. Den tekniska utvecklingen går fort och specialiserade instrument lanseras ständigt. En typ av dessa specialiserade terrestra laserskannrar är handhållna laserskannrar. De är främst framtagen för att generera punktmoln av utrymmen och mindre objekt där den vanliga laserskannern har svårigheter att skanna. Då de handhållna laserskannrarna är relativt ny är forskningen på instrumenten begränsad och i avsaknad på standardiserade kontrollmetoder finns ett behov att studera instrumenten. I detta examensarbete studerades därför den handhållna laserskannern FARO Freestyle X för att undersöka hur bra den handhållna laserskanningstekniken egentligt är samt vilka begränsningar instrumenten har. Detta gjordes genom att jämföra punktmoln från FARO Freestyle X med referenspunktmoln genererat av Leicas multistation MS50. För att studera instrumentet valdes flertalet parametrar som skanningsavståndet, användarvänlighet, tidsåtgång och prestanda. Med dessa parametrar ansågs det finnas tillräckligt med grund för att dra slutsatser om instrumentets fördelar/nackdelar och begränsningar. Resultatet av punktmolnsjämförelsen från kort avstånd visade avvikelser under 10 mm för att sedan på längre avstånd öka till fåtalet centimetrar. Volymbegränsningen påvisade inget avvikande resultat. Vilket medför att förflyttning av instrumentet inte påverkar resultatet avsevärt. Instrumentets Akilleshäl är de brus som uppstår vid skanning från längre avstånd, då noterades ett brus på ca 30 mm. Men även typ av objekt som skannas påverkar bruset något. Bruset på väggen visade störst avvikelse medan bruset på bordet var lägst. Repeterbarheten visade gott resultat visuellt och hade liknande avvikelser. Instrumentet har en god förmåga att återskapa objekt då upplösningstestet påvisar bra prestanda. Främsta fördelen med instrumentet är vid dess effektiva dokumentation av mindre objekt, men även lite större utrymmen där mätosäkerhet på centimeternivå krävs. Användarvänligheten är god för instrumentet och de färglagda punktmolnen tar visualiseringen till en ny nivå. Resultatet av studien visar att de handhållna laserskannrarna kan, i vissa fall, utmana den traditionella laserskannern.
Terrestrial laser scanners (TLS) have been common in geodetic measurements for over 10 years. The technology is developing rapidly and specialized instruments are launched constantly. One type of these specialized TLS instruments are hand-held laser scanners. They are designed primarily to generate point clouds of spaces and small objects where the traditional tripod mounted laser scanner has difficulties to scan. When the hand-held laser scanners are relatively new, the research on the instruments is limited, and the lack of standardized control methods. With that in mind it is important to study the instruments. In this thesis the hand-held laser scanner FARO Freestyle X was investigated on how well the handheld laser scanning technology really is and what limitations the instruments have. This was done by comparing point clouds from FARO Freestyle X with reference point cloud generated by Leica's multi-station MS50. To study the instrument a number of parameters was investigated such as scanning distance, ease of use, time and performance. These parameters were considered to be sufficient basis for conclusions about the instrument's advantages/disadvantages and limitations. The result of the point cloud comparison from the short distance showed deviations around 10 mm and then increase to few centimeters at longer distances. Volume limitation control showed no differences compared to the scanning from short distance. This means that moving the instrument does not affect the results significantly. The instrument's Achilles' heel is the noise that occurs when scanning from longer distances, about 30 mm deviations. Even the type of object affects the noise. The noise on the wall showed the greatest deviation while the noise on the table indicated the lowest results. The repeatability showed good results visually and had similar deviations. The instrument has a good ability to recreate objects when the resolution test demonstrates good performance. Main advantage of the instrument is its effective documentation of smaller objects, but also some larger areas where the uncertainty of centimeter-level is required. The ease of use can be described as good and the colored point clouds takes visualization to a new level. The results of the study show that the hand-held laser scanners can, potentially, challenge the traditional laser scanner.

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Freitag, Walburga. "Contergan eine genealogische Studie des Zusammenhangs wissenschaftlicher Diskurse und biographischer Erfahrungen". Münster New York München Berlin Waxmann, 2003. http://www.waxmann.com/kat/1503.hml.

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Huamán, Layme José Antonio. "Localización, seguimiento y reconocimiento de rostros empleando métodos estadísticos PCA y HMME". Universidad Nacional de Ingeniería. Programa Cybertesis PERÚ, 2007. http://cybertesis.uni.edu.pe/uni/2007/huaman_lj/html/index-frames.html.

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Loots, Erik. "HME Management in Mega Mining: Sishen Mine – South Africa". Thesis, University of Canterbury. Engineering Management, 2013. http://hdl.handle.net/10092/7441.

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Rascão, Madalena da Silva Ruivo Coreixas. "Aquisição de dados LiDAR com TLS e HMLS para deteção de árvores individuais". Master's thesis, ISA, 2019. http://hdl.handle.net/10400.5/21291.

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Mestrado em Engenharia Florestal e dos Recursos Naturais / Instituto Superior de Agronomia. Universidade de Lisboa
LiDAR (Light Detection And Ranging) é um sistema baseado nos princípios de Deteção Remota que permite medir distâncias com base no tempo da trajetória da radiação laser, desde que é emitida pelo aparelho até que retorna ao recetor depois de ser refletida numa superfície sólida. A aplicabilidade deste sistema é abrangente a várias áreas da engenharia e prende-se com a capacidade que o mesmo tem de recolher e armazenar dados tridimensionais em forma de nuvens de pontos de qualquer objeto sólido sobre a superfície terrestre. No sector florestal, este sistema permite estimar características dos povoamentos e digitalizar uma extensa área de floresta, de uma forma automatizada, rápida e com detalhe na ordem dos milímetros. O objetivo do presente trabalho é avaliar a capacidade do sistema LiDAR na individualização da árvore comparando as coordenadas estimadas obtidas com dois métodos LiDAR - HMLS (Held-Hand Mobile Laser Scanner) e TLS (Terrestrial Taser Scanner) - com as coordenadas obtidas com GPS sub-métrico, pelo método tradicional de campo, num ensaio clonal de Eucalyptus globulus Labill. com 10 anos de idade. O presente estudo serviu também como primeira abordagem ao desempenho dos dois métodos LiDAR na obtenção de diâmetros às várias alturas do tronco, recorrendo aos algoritmos disponíveis no software R. Para a deteção das árvores individuais, os resultados demonstraram que, em média, o método TLS detetou 65,1% das árvores, enquanto o método HMLS detetou 44,7% das árvores, para todas as parcelas de estudo. Comprovou-se ainda que o levantamento com HMLS só é vantajoso para terrenos regulares e percursos retos. Concluiu-se que deve ser efetuada uma melhoria nos processos associados à utilização do algoritmo SLAM (Simultaneous Localization And Mapping) e salientou-se a importância de utilizar pontos de referência em campo para a obtenção de nuvens de pontos de melhor qualidade
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Aljubiri, Abdullah. "AN IMPLEMENTATION STRATEGY FOR LEAN MANUFACTURING IN HIGHMIX AND LOW VOLUME (HMLV) ENVIRONMENT". University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1564787755980795.

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Più fonti

Libri sul tema "HMLE"

1

Urban, Milo. Hmly na úsvite. 4^a ed. Bratislava: Slovenský spisovatel̕, 1990.

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2

Bethell, Jean. Beru hmte Wissenschaftler. Nu rnberg: Tessloff, 1987.

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3

Agency, Medical Devices. Patient monitor: HME LifePulse 400. London: Medical Devices Agency, 2003.

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Agency, Medical Devices. ' Active' heat and moisture exchanger: Tomtec HME-Booster. London: Medical Devices Agency, 2001.

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5

Der ungeza hmte Mann: Auf dem Weg zu einer neuen Ma nnlichkeit. 3^a ed. Giessen: Brunnen-Verl., 2004.

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6

Improving Scottish education: A report by HMIE on inspection and review 2005-2008. Livingston: HM Inspectorate of Education, 2009.

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7

Perth & Kinross Council. Education & Children's Services. Dunbarney Primary School: HMIE Standards and Quality Inspection follow-through arrangements : report on progress. Perth: Perth & Kinross Council, 2005.

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Perth & Kinross Council. Education & Children's Services. Guildtown Primary School: HMIE Standards and Quality Inspection follow-through arrangements : report on progress. Perth: Perth & Kinross Council, 2004.

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Perth & Kinross Council. Education & Children's Services. Meigle Primary School: HMIE Standards and Quality Inspection follow-through arrangements : report on progress. Perth: Perth & Kinross Council, 2004.

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10

Working the deadbeat: 50 lives that changed Canada. Toronto: Anansi, 2012.

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Capitoli di libri sul tema "HMLE"

1

Multisilta, Jari, Kostadin Antchev e Seppo Pohjolainen. "Hypermedia for mathematics: authoring courses with HMLE". In World Conference on Computers in Education VI, 987–97. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-0-387-34844-5_92.

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2

Harr, Jeffrey N., Philip F. Stahel, Phillip D. Levy, Antoine Vieillard-Baron, Yang Xue, Muhammad N. Iqbal, Jeffrey Chan et al. "HME". In Encyclopedia of Intensive Care Medicine, 1152. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_3146.

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3

Ricard, Jean-Damien, Alexandre Boyer e Didier Dreyfuss. "Heat and Moisture Exchangers (HME)". In Humidification in the Intensive Care Unit, 27–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-02974-5_4.

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4

Schieferdecker, Henrike L., Daniela C. Schmidt, Reiner Ullrich, Hans-Ulrich Jahn, Heike Hirseland e Martin Zeitz. "Phenotype of HML-1-Positive and HML-1-Negative T Lymphocytes in the Human Intestinal Lamina Propria". In Advances in Experimental Medicine and Biology, 77–79. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1941-6_13.

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Ramli, Dzati Athiar, Ahmad Fauzan Kadmin, Mohd Yusoff Mashor, Nor Ashidi e Mat Isa. "Diagnosis of Cervical Cancer Using Hybrid Multilayered Perceptron (HMLP) Network". In Lecture Notes in Computer Science, 591–98. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30132-5_82.

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Voss, A., e A. Raedler. "Funktionelle Charakterisierung HML-positiver Zellen bei Morbus Crohn". In Ökosystem Darm, 258–60. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-75075-5_47.

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Aceto, Luca, Antonis Achilleos, Duncan Paul Attard, Léo Exibard, Adrian Francalanza e Anna Ingólfsdóttir. "A Monitoring Tool for Linear-Time $$\mu $$HML". In Lecture Notes in Computer Science, 200–219. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-08143-9_12.

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8

Bin Hashim, Fakroul Ridzuan, John J. Soraghan e Lykourgos Petropoulakis. "Multi-classify Hybrid Multilayered Perceptron (HMLP) Network for Pattern Recognition Applications". In IFIP Advances in Information and Communication Technology, 19–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33409-2_3.

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Eidelman, Mark. "Correction of Forearm Deformities in Hereditary Multiple Exostoses (HME)". In Limb Lengthening and Reconstruction Surgery Case Atlas, 1–9. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02767-8_258-1.

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Brown, Chad, James DiNunzio, Michael Eglesia, Seth Forster, Matthew Lamm, Michael Lowinger, Patrick Marsac et al. "HME for Solid Dispersions: Scale-Up and Late-Stage Development". In Advances in Delivery Science and Technology, 231–60. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1598-9_7.

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Atti di convegni sul tema "HMLE"

1

Azmi, Asfar S., Aliccia Bollig-Fisher, Bin Bao, Bum Joon-Park, SH Lee, Gyu-Yong Song, Ramzi M. Mohammad e Fazlul H. Sarkar. "Abstract 5234: Network interrogations on SNAIL inhibitor GN-25 induced perturbations in HMLE-SNAIL cell line models." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5234.

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2

Feng, Shanshan, Lucas Vinh Tran, Gao Cong, Lisi Chen, Jing Li e Fan Li. "HME". In SIGIR '20: The 43rd International ACM SIGIR conference on research and development in Information Retrieval. New York, NY, USA: ACM, 2020. http://dx.doi.org/10.1145/3397271.3401049.

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3

Heins, Dustin, Greg Mozsgai e Angelo Tanzarella. "Inspection criteria for HMPE rope". In 2013 MTS/IEEE OCEANS. IEEE, 2013. http://dx.doi.org/10.1109/oceans-bergen.2013.6608018.

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4

Belsis, Petros, Kostas Fragos, Stefanos Gritzalis e Christos Skourlas. "SF-HME system". In the 2006 ACM symposium. New York, New York, USA: ACM Press, 2006. http://dx.doi.org/10.1145/1141277.1141360.

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5

Leite, Sergio, e Jorn Boesten. "HMPE Mooring Lines for Deepwater MODUs". In OTC Brasil. Offshore Technology Conference, 2011. http://dx.doi.org/10.4043/22486-ms.

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6

Vlasblom, Martin, Tom Engels e Corentin Humeau. "Tension endurance of HMPE fiber ropes". In OCEANS 2017 - Aberdeen. IEEE, 2017. http://dx.doi.org/10.1109/oceanse.2017.8084939.

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Vlasblom, Martin, Rigo Bosman, Jose Canedo e Peter Davies. "Designing HMPE fiber ropes on durability". In OCEANS 2019 - Marseille. IEEE, 2019. http://dx.doi.org/10.1109/oceanse.2019.8867099.

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8

Adnan, Ja’afar, K. A. Ahmad, Muhamad Hadzren Mat, Zairi Ismael Rizman e Shahril Ahmad. "Cardiac abnormality prediction using HMLP network". In INTERNATIONAL CONFERENCE ON ENGINEERING AND TECHNOLOGY (IntCET 2017). Author(s), 2018. http://dx.doi.org/10.1063/1.5022899.

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9

Varga, Edit, Imre Horva´th e Zolta´n Rusa´k. "Investigation of the Quality of Shape Definition by Hand Motions". In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-35324.

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In preceding research, the concept of the Hand Motion Language (HML) was developed as a novel and intuitive interface for Computer Aided Conceptual Design (CACD) systems. Also, a pilot implementation of the HML interpreter was developed and tested. Current research focuses on the applicability of HML in real-life situations. Firstly, this paper reports on the connection of the HML to the Vague Discrete Interval Modeler (VDIM) as an input interface. Together with the HML interpreter, it serves as a testing environment. Secondly, the paper concentrates on the design and evaluation of an experiment which was done to study the quality of shape definition by hand motions. Three quality measures were established: (i) fidelity of the generated surfaces, (ii) accuracy of the surface manipulation functions, and (iii) difficulty of modeling. Fidelity is the degree to which the representation of a shape is similar to an ideal shape. Accuracy is defined as the degree of conformity of an indicated value, such as width or angle, to an ideal value. With regards to complexity, it is interesting for us how the number of geometric HML words relates to the number of manipulative HML words that has to be issued to model a given shape. A pilot study was designed and performed to gain insight into the problems when generating surfaces by hand motions. The task given to the users was completed within a few steps; however, the quality of the surfaces has to be improved.

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Corbetta, I., e F. Sloan. "HMPE Mooring Line Trial for Scarabeo III". In Offshore Technology Conference. Offshore Technology Conference, 2001. http://dx.doi.org/10.4043/13272-ms.

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Rapporti di organizzazioni sul tema "HMLE"

1

Seetho, Isaac M., William D. Brown e Harry E. Martz, Jr. EXD HME MicroCT Data Acquisition, Processing and Data Request Overview. Office of Scientific and Technical Information (OSTI), dicembre 2016. http://dx.doi.org/10.2172/1342052.

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2

Geyer, Anton. Evaluation der Klinischen Forschungsgruppen. Abschlussbericht von inspire research im Auftrag der Deutschen Forschungsgemeinschaft (DFG). DFG - Deutsche Forschungsgemeinschaft, settembre 2022. http://dx.doi.org/10.22163/fteval.2022.583.

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Die Deutsche Forschungsgemeinschaft (DFG) fördert seit dem Jahr 2001 Klinische Forschungsgruppen (KFO) an hochschulmedizinischen Einrichtungen (HME). Mit KFO sollen wissenschaftliche Arbeitsgruppen, die sich krankheits- oder patientenorientierter (translationaler) klinischer Forschung widmen, dauerhaft verankert und vernetzt werden. Die Zusammenarbeit in einer KFO soll zu Ergebnissen führen, die mit den Möglichkeiten der DFG-Einzelförderung nicht erreicht werden können. Die Evaluation liefert eine Bestandsaufnahme über den Programmverlauf und prüft, inwieweit es dem Instrument KFO gelingt die erwarteten Ziele zu erreichen.

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Orning, Tanja. Professional identities in progress – developing personal artistic trajectories. Norges Musikkhøgskole, agosto 2018. http://dx.doi.org/10.22501/nmh-ar.544616.

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We have seen drastic changes in the music profession during the last 20 years, and consequently an increase of new professional opportunities, roles and identities. We can see elements of a collective identity in classically trained musicians who from childhood have been introduced to centuries old, institutionalized traditions around the performers’ role and the work-concept. Respect for the composer and his work can lead to a fear of failure and a perfectionist value system that permeates the classical music. We have to question whether music education has become a ready-made prototype of certain trajectories, with a predictable outcome represented by more or less generic types of musicians who interchangeably are able play the same, limited canonized repertoire, in more or less the same way. Where is the resistance and obstacles, the detours and the unique and fearless individual choices? It is a paradox that within the traditional master-student model, the student is told how to think, play and relate to established truths, while a sustainable musical career is based upon questioning the very same things. A fundamental principle of an independent musical career is to develop a capacity for critical reflection and a healthy opposition towards uncontested truths. However, the unison demands for modernization of institutions and their role cannot be solved with a quick fix, we must look at who we are and who we have been to look at who we can become. Central here is the question of how the music students perceive their own identity and role. To make the leap from a traditional instrumentalist role to an artist /curator role requires commitment in an entirely different way. In this article, I will examine question of identity - how identity may be constituted through musical and educational experiences. The article will discuss why identity work is a key area in the development of a sustainable music career and it will investigate how we can approach this and suggest some possible ways in this work. We shall see how identity work can be about unfolding possible future selves (Marcus & Nurius, 1986), develop and evolve one’s own personal journey and narrative. Central is how identity develops linguistically by seeing other possibilities: "identity is formed out of the discourses - in the broadest sense - that are available to us ..." (Ruud, 2013). The question is: How can higher music education (HME) facilitate students in their identity work in the process of constructing their professional identities? I draw on my own experience as a classically educated musician in the discussion.

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