Tesi: "HMLE" – Grafiati

1

Bronner, Anna [Verfasser], e Karl [Akademischer Betreuer] Sotlar. "Analysen von BRCA1 und BRMS1 in durch TWIST1 induzierbarem EMT-Modell in HMLE-Zellen / Anna Bronner ; Betreuer: Karl Sotlar". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221960598/34.

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Salman, Mohammed, e Michael Afrem. "Produktionseffektivisering inom HMLV-miljöer". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-28499.

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Flertal små företag med stor produktflora i små volymer har uttryckt en vilja för att implementera Lean-verktyg i deras företag och ofta har det inte genererat de goda resultat de förväntat sig. För att dessa företag ska bli framgångsrika i sitt implementerande av Lean gäller det att de utvärderar vilka verktyg som gynnar företaget och vilka som inte medför förbättring. Problematiken som uppstår i detta är kulturella förändringar där det är vanligt att arbetare inte visar motivation eller intresse för att förändra sin tidigare arbetsrutin och här har ledningen stort ansvar att motivera arbetarna till att vara delaktiga och välkomna förbättringar. För att kunna undersöka detta utförligt har en fallstudie och litteraturstudie utförts för att studera: 1) Hur HMLV-företag bör gå tillväga för att arbeta med Lean, 2) vilka Lean-principer som går att implementera i HMLV-miljön och slutligen 3) hur man övertygar medarbetarna att ändra sitt befintliga arbetssätt till en mer standardiserad arbetsform. Resultat från litteraturstudien visar hur viktigt det är att studera vilka verktyg som passar in i ett specifikt företag och att man ska samla information om hur man ska gå tillväga innan man beslutar sig för något. Litteraturstudien visar även att ledningen har en stor roll i att övertyga medarbetarna till att engagera sig i förändringsarbetet. Resultat från fallstudien styrker litteraturstudiens påståenden om hur viktigt det är att studera vilka verktyg som passar in i ett specifikt företag och hur dessa företag bör gå tillväga. Fallstudien styrker också påståendet att ledningen har en stor roll i att motivera arbetarna men även att arbetarna i sin tur måste ta sitt ansvar och engagera sig.

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Mohammadpour, Violet, e Sebastian Häll. "Supporting the development of a HMLV production cell". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-54532.

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Production system development is challenging for manufacturing companies, and development of HMLV production cells entails additional challenges. Thus, the aim of this study is to support the development of a HMLV production cell, and the following research questions were asked: RQ1: What are the challenges of developing a HMLV production cell? RQ2: What are the critical factors to consider when developing a HMLV production cell? RQ3: How can the development of a HMLV production cell be supported? A literature review in combination with a case study were performed to fulfill the aim and answer the research questions. The literature review was conducted to gain knowledge from previous studies, whilst the case study was performed to complement the theoretical findings. The selected case is the development of a HMLV production cell in the department of engine machining at Scania, which is planned to perform production activities for various departments of Scania. The primary data was collected through observations and interviews. The identified challenges of developing a HMLV production cell were production planning, utilization of equipment, product quality and material flow. The identified critical factors to consider when developing a HMLV production cell were production flexibility, production competence, production technology, pilot production, manufacturing strategy, order management system and standardization. The identified challenges of developing a HMLV production cell and the critical factors to consider when developing a HMLV production cell can support manufacturing companies by informing what challenges to expect prior to developing a HMLV production cell, and what critical factors can mitigate these challenges. Two ways of supporting the development of a HMLV production cell are recommended to Scania: creating a structured order management system and performing a pilot production for the milling operation of the core box reparation process. During this study, it was discovered that different HMLV production cells have different capabilities, challenges, and therefore also different critical factors. As such, recommendation for further research is to investigate how the development of different types of HMLV production cells can be supported by using a multiple case study research design, and to compare the challenges and critical factors for the development for the different types of HMLV production cells.

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Andersson, Martina. "Processeffektivisering i HMLV-miljö med hjälp av Lean". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-44037.

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Syfte och frågeställningar: Syftet med examensarbetet är - att genom att kartlägga nuvarande process och identifiera slöserier i den - undersöka om företag inom HMLV-miljöer kan bli mer effektiva genom att använda sig av verktyg och principer inom lean produktion. Utifrån syftet formulerades och besvarades följande två frågeställningar: 1) Har Lean betydande inverkan även vid produktion av lägre volymer? 2) Hur kan företag inom HMLV - produktion som tillverkar mot order bli mer effektiva och öka kvaliteten med implementering av Lean? Metod och genomförande: En fallstudie har utförts på ett litet HMLV-företag som tillverkar produkter mot kundorder. Kvalitativ som kvantitativ data har främst inhämtats genom observationer, mätningar, semistrukturerade och ostrukturerade intervjuer samt genom analysering av företagsdokument i form av ordrar och beställningshistorik. För att knyta an fallstudien till teorin har en litteraturstudie genomförts i vilken information har inhämtats från såväl böcker som vetenskapliga artiklar. Resultat: Fallstudien visar efter en kartläggning av processflödet av en artikel att företaget på vilket studien utfördes idag inte jobbar med Lean i någon större utsträckning. Kartläggningen visar att det förekommer flertalet slöserier i form av väntan mellan processer, onödiga rörelser mellan stationer samt att artikeln rör sig ojämnt genom de olika processerna i flödet varför det varit en komplex uppgift att kartlägga densamma. Slutsatser: De slutsatser som kan dras från fallstudien i relation till den teoretiska referensramen är att företag inom HMLV-produktion kan använda sig av vissa leanverktyg för att bli mer effektiva medan andra verktyg är sämre lämpade i den nämnda miljön. Vidare kan några av de 14 principerna anammas för att företaget både ska bli mer effektiva men även för att öka kvaliteten på sina produkter. Nyckelord: Lean, logistic, high-mix-low-volume (HMLV), production improvement.

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Andersson, Jonas, e Patrik Hedlund. "Undersökning om handhållna laserskannrar vid detaljmätning : En jämförelse mellan multistationen Leica Nova MS50 och den handhållna laserskannern FARO Freestyle X". Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22200.

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Terrestra laserskannrar har varit vanligt förekommande i geodetiska mätningar i över 10 år. Den tekniska utvecklingen går fort och specialiserade instrument lanseras ständigt. En typ av dessa specialiserade terrestra laserskannrar är handhållna laserskannrar. De är främst framtagen för att generera punktmoln av utrymmen och mindre objekt där den vanliga laserskannern har svårigheter att skanna. Då de handhållna laserskannrarna är relativt ny är forskningen på instrumenten begränsad och i avsaknad på standardiserade kontrollmetoder finns ett behov att studera instrumenten. I detta examensarbete studerades därför den handhållna laserskannern FARO Freestyle X för att undersöka hur bra den handhållna laserskanningstekniken egentligt är samt vilka begränsningar instrumenten har. Detta gjordes genom att jämföra punktmoln från FARO Freestyle X med referenspunktmoln genererat av Leicas multistation MS50. För att studera instrumentet valdes flertalet parametrar som skanningsavståndet, användarvänlighet, tidsåtgång och prestanda. Med dessa parametrar ansågs det finnas tillräckligt med grund för att dra slutsatser om instrumentets fördelar/nackdelar och begränsningar. Resultatet av punktmolnsjämförelsen från kort avstånd visade avvikelser under 10 mm för att sedan på längre avstånd öka till fåtalet centimetrar. Volymbegränsningen påvisade inget avvikande resultat. Vilket medför att förflyttning av instrumentet inte påverkar resultatet avsevärt. Instrumentets Akilleshäl är de brus som uppstår vid skanning från längre avstånd, då noterades ett brus på ca 30 mm. Men även typ av objekt som skannas påverkar bruset något. Bruset på väggen visade störst avvikelse medan bruset på bordet var lägst. Repeterbarheten visade gott resultat visuellt och hade liknande avvikelser. Instrumentet har en god förmåga att återskapa objekt då upplösningstestet påvisar bra prestanda. Främsta fördelen med instrumentet är vid dess effektiva dokumentation av mindre objekt, men även lite större utrymmen där mätosäkerhet på centimeternivå krävs. Användarvänligheten är god för instrumentet och de färglagda punktmolnen tar visualiseringen till en ny nivå. Resultatet av studien visar att de handhållna laserskannrarna kan, i vissa fall, utmana den traditionella laserskannern.
Terrestrial laser scanners (TLS) have been common in geodetic measurements for over 10 years. The technology is developing rapidly and specialized instruments are launched constantly. One type of these specialized TLS instruments are hand-held laser scanners. They are designed primarily to generate point clouds of spaces and small objects where the traditional tripod mounted laser scanner has difficulties to scan. When the hand-held laser scanners are relatively new, the research on the instruments is limited, and the lack of standardized control methods. With that in mind it is important to study the instruments. In this thesis the hand-held laser scanner FARO Freestyle X was investigated on how well the handheld laser scanning technology really is and what limitations the instruments have. This was done by comparing point clouds from FARO Freestyle X with reference point cloud generated by Leica's multi-station MS50. To study the instrument a number of parameters was investigated such as scanning distance, ease of use, time and performance. These parameters were considered to be sufficient basis for conclusions about the instrument's advantages/disadvantages and limitations. The result of the point cloud comparison from the short distance showed deviations around 10 mm and then increase to few centimeters at longer distances. Volume limitation control showed no differences compared to the scanning from short distance. This means that moving the instrument does not affect the results significantly. The instrument's Achilles' heel is the noise that occurs when scanning from longer distances, about 30 mm deviations. Even the type of object affects the noise. The noise on the wall showed the greatest deviation while the noise on the table indicated the lowest results. The repeatability showed good results visually and had similar deviations. The instrument has a good ability to recreate objects when the resolution test demonstrates good performance. Main advantage of the instrument is its effective documentation of smaller objects, but also some larger areas where the uncertainty of centimeter-level is required. The ease of use can be described as good and the colored point clouds takes visualization to a new level. The results of the study show that the hand-held laser scanners can, potentially, challenge the traditional laser scanner.

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Freitag, Walburga. "Contergan eine genealogische Studie des Zusammenhangs wissenschaftlicher Diskurse und biographischer Erfahrungen". Münster New York München Berlin Waxmann, 2003. http://www.waxmann.com/kat/1503.hml.

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Huamán, Layme José Antonio. "Localización, seguimiento y reconocimiento de rostros empleando métodos estadísticos PCA y HMME". Universidad Nacional de Ingeniería. Programa Cybertesis PERÚ, 2007. http://cybertesis.uni.edu.pe/uni/2007/huaman_lj/html/index-frames.html.

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Loots, Erik. "HME Management in Mega Mining: Sishen Mine – South Africa". Thesis, University of Canterbury. Engineering Management, 2013. http://hdl.handle.net/10092/7441.

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Rascão, Madalena da Silva Ruivo Coreixas. "Aquisição de dados LiDAR com TLS e HMLS para deteção de árvores individuais". Master's thesis, ISA, 2019. http://hdl.handle.net/10400.5/21291.

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Mestrado em Engenharia Florestal e dos Recursos Naturais / Instituto Superior de Agronomia. Universidade de Lisboa
LiDAR (Light Detection And Ranging) é um sistema baseado nos princípios de Deteção Remota que permite medir distâncias com base no tempo da trajetória da radiação laser, desde que é emitida pelo aparelho até que retorna ao recetor depois de ser refletida numa superfície sólida. A aplicabilidade deste sistema é abrangente a várias áreas da engenharia e prende-se com a capacidade que o mesmo tem de recolher e armazenar dados tridimensionais em forma de nuvens de pontos de qualquer objeto sólido sobre a superfície terrestre. No sector florestal, este sistema permite estimar características dos povoamentos e digitalizar uma extensa área de floresta, de uma forma automatizada, rápida e com detalhe na ordem dos milímetros. O objetivo do presente trabalho é avaliar a capacidade do sistema LiDAR na individualização da árvore comparando as coordenadas estimadas obtidas com dois métodos LiDAR - HMLS (Held-Hand Mobile Laser Scanner) e TLS (Terrestrial Taser Scanner) - com as coordenadas obtidas com GPS sub-métrico, pelo método tradicional de campo, num ensaio clonal de Eucalyptus globulus Labill. com 10 anos de idade. O presente estudo serviu também como primeira abordagem ao desempenho dos dois métodos LiDAR na obtenção de diâmetros às várias alturas do tronco, recorrendo aos algoritmos disponíveis no software R. Para a deteção das árvores individuais, os resultados demonstraram que, em média, o método TLS detetou 65,1% das árvores, enquanto o método HMLS detetou 44,7% das árvores, para todas as parcelas de estudo. Comprovou-se ainda que o levantamento com HMLS só é vantajoso para terrenos regulares e percursos retos. Concluiu-se que deve ser efetuada uma melhoria nos processos associados à utilização do algoritmo SLAM (Simultaneous Localization And Mapping) e salientou-se a importância de utilizar pontos de referência em campo para a obtenção de nuvens de pontos de melhor qualidade
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Aljubiri, Abdullah. "AN IMPLEMENTATION STRATEGY FOR LEAN MANUFACTURING IN HIGHMIX AND LOW VOLUME (HMLV) ENVIRONMENT". University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1564787755980795.

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Gaete, O’bryan, e Nybjörk William Bruksås. "Analys och optimering av transmissionslina till ett vinschbaserat vågkraftverk". Thesis, KTH, Skolan för industriell teknik och management (ITM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279754.

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Detta examensarbete syftar sig till att undersöka olika konceptuella lösningar utav en transmissionslina för ett vågkraftverk. De tre olika konceptuella lösningarna är; ett rep av materialet HMPE (High Modulus Polyethylene), en transmissionslina baserad på KONE Ultrarope samt en transmissionskedja baserad på elastomera lager. Dessa har indelats i nämnd följd enligt koncept A, koncept B och koncept C. Analysen av dessa grundar sig i befintlig information och kunskap. Från dessa koncept har sedan koncept A valts att studeras vidare för optimering, vilket gjordes genom bedömning enligt Pughmetoden. Verktyget Solid Edge har använts vid framtagandet av koncept A och B. Vid optimeringen för koncept A så konstruerades en trumma för att minimera nötning, maximera repets livslängd samt för att uppnå de satta kraven.
This bachelor’s thesis aims to examine different conceptual solutions of transmission lines for a winch-based wave power plant. The different concepts are; a rope of the material HMPE (High Modulus Polyethylene), a transmission line based on KONE Ultrarope and a transmission chain based on elastomeric bearings. These have then been divided in that order into concept A, concept B and concept C. The analyses of these are based on existing information and knowledge. From these concepts, concept A has been chosen to be further analyzed and optimized. Concept A was chosen by following the method of a Pugh matrix. The modeling software Solid Edge has been used when developing concepts, A and B. Concept A was optimized by designing a drum that minimize abrasion, maximize the life of the rope and was also adjusted for reaching the specific requirements.

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Kasljevic, Ivan, e Emir Mustafic. "Theory of Constraints och Lean Production i High-mix Low-volume företag". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-28403.

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Konkurrensen i tillverkningsföretag ökar ständigt och detta medför att det ställs hårda krav på produktkvalitet och förmågan att leverera produkter i tid. För att företag ska kunna nå upp till dessa mål krävs utveckling och ständiga förbättringar i takt med den växande marknaden. Detta uppnås på olika sätt men ett vanligt sätt är att arbeta med förbättringsmetodiker. Val av förbättringsmetodik beror på företagets tillverkning, kunskap inom företaget och resurser inom företaget. Att välja förbättringsmetodik anpassat till den egna organisationen är väldigt svårt för många organisationer och många organisationer ställer sig frågan: ”Vilken metod passar bäst för den egna organisationen?”. Målet med examensarbetet är att undersöka om och hur Lean Production och Theory of Constraints kan användas i företag med high-mix low-volume produktion. Med hjälp av en litteraturstudie och en fallstudie har följande frågor besvarats: 1) hur Lean Prodution och Theory of Constraints används i en HMLV produktion och hur dessa kombineras, 2) hur produktionsflödet styrs enligt Lean Production och Theory of Constraints för att effektivisera en produktionsprocess i ett HMLV företag, 3) vilka personliga paradigm och policys det uppstår enligt Lean Production och Theory of Constraints i HMLV företag och vad sambandet mellan dessa och kvalitet är. Resultat från litteraturstudien och fallstudien visar att Lean Production och dess verktyg går bra att använda kombinerat med Theory of Constraints i HMLV företag med vissa undantag. Dessa undantag är dock inga undantag som säger att Lean Production och dess verktyg inte går att använda i HMLV företag i kombination med Theory of Constraints. Dessa undantag behöver endast anpassas för HMLV produktion. Resultaten visade också att standardiserat arbete i en produktion har en avgörande roll när Lean Production och Theory of Constraints används. Standardiserat arbete bidrar till att fortsatt utveckling och implementering underlättas. Resultaten visar även på att produktionsflödet kan anpassas med hjälp av metoder inom Lean Production och Theory of Constraints och att detta göras bäst när dessa två metodiker kombineras. Vidare visade resultaten att nya investeringar i form av ny utrustning inte är nödvändiga i många fall. Detta förutsätter att flaskhalsar, så som personliga paradigm och policys, identifieras. Resultaten visade även att kvaliteten är direkt kopplad till dessa två flaskhalsar och att en investering i ledarskap är att föredra.
Competition between manufacturing companies is constantly increasing and this causes high demands on product quality and ability to deliver products in time. For companies to be able to reach these goals it is necessary to work with development and continuous improvements and respond to the current pace of the market. This can be achieved in different ways, but a common method is to work with improvement methodologies. Selecting which improvement methodologies to use depends on a company’s manufacturing, knowledge, and resources. Many organisations find it difficult to choose improvement methodologies for their particular organisation and ask the question: “Which method is best suited for our organisation?”. The goal of this study is to examine whether and how Lean Production and Theory of Constraints can be utilized in companies with high-mix low-volume production. By performing a literature review and a case study the following questions have been answered: 1) how Lean production and Theory of constraints are utilized in a HMLV production system and how they can be combined, 2) how the production flow is controlled according to Lean Production and Theory of Constraints to improve the efficiency of a production process in a HMLV company, 3) what personal paradigms and policys arise according to Lean Production and Theory of Constraints in HMLV company and what the relationship between these and quality is. Results from the literature review and case study show that Lean Production and its tools are possible to use in a combination with Theory of Constraints in HMLV companies with some exceptions. However there is no exceptions saying that Lean Production and its tools combined with Theory of Constraints can not be utilized in HMLV companies. These exceptions only need to be adjusted for HMLV production. The results also showed that standardized work in a production process plays a crucial role when combining Lean production with Theory of Constraints. Standardized work contributes to facilitation of further development and implementation. The results show that the production flow can be adjusted using methods from Lean Production and Theory of Constraints, and that this is done best by combining these two methodologies. Furthermore, the results showed that in many cases new investments in the form of new equipment are not necessary. This assumes that bottlenecks, such as personal paradigms and policies are identified. The results showed that quality is directly linked to these two bottlenecks and that an investment in management is preferable.

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Irlbacher, Horst. "A role for Sum1 in HML silencing and replication initiation in Saccharomyces cerevisiae". Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976493497.

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Tajra, FÃbio Solon. "Biotechnological potential of the red marine alga Hypnea musciformis (HML) applied to Dentistry". Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5285.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico
Dental Caries is an infectious disease naturally multi-factorial that begins in the childhood, able to spread its intensity and prevalence according to the mouth ambient conditions of each host. The risk of the patients to develop, in some time of their lives, carious lesions can be measured through a complex analysis using health determinant factors and other specific factors of the health-disease process. Since the dental caries forward diagnostic as well as the review of the auxiliary determinant factors of the dental caries danger evaluation, the treatment becomes simpler, less invasive and costing lower. It has been quite broad-casted lately the use of lectins to diagnose and to prevent some diseases. When dealing with dental caries disease, through many years this strategy has been explored still inceptively. Looking through this perspective, the goal of this trial was to investigate the biotechnological potential of the red marine alga Hypnea musciformis (HML) applied to Dentistry. It is about an explanatory-experimental study of quantitative approach through the health questionnaire and data statistics analysis. The research makes reference to some comparative analysis of salivary tests and the cariogenic activity in twelve year-old students and it searches to evaluate the biotechnological potentialities of the lectin from the red marine alga Hypnea musciformis (HML) in the diagnose and prevention of the dental caries. The concentration area of this trial was the macromolecules/ lectin biotechnological application. In the present trial were compared obtained results through the application of the conventional clinical exams to dental caries and salivary tests of dental caries activity pointed by the CARIOGRAMÂ program in association with lab analysis using specific lectins. From this trial, it has been concluded that, about lectins as a biotechnological potential to prevention and diagnose of the dental caries, it has been noticed that there is recognition of resident glycoconjugate on pacifier saliva of high and low risk observed in immunofluorescence pattern. The results showed that the tested lectin has the capacity to intervene on the bacterial growth in a negative way, it is being distinguished statistically (p<0,01) in relation to control group of saline and BSA. However, inhibition studies of the microbial biofilms using the HML are being programmed to evaluate the using possibility of these protein as biotech input to be used for dental caries prevention. It could be said also that the obtained results by the use of HML in the antimicrobial activity were promising, showing that this lectin has presented antimicrobial activity even on very small amounts. As to the use of these protein in the biofilm formation and developing there was no characteristic pattern.
A cÃrie Ã uma doenÃa infecciosa de natureza multifatorial que se inicia na infÃncia, podendo aumentar de intensidade e prevalÃncia de acordo com as condiÃÃes do ambiente bucal de cada hospedeiro. O risco do paciente em desenvolver, em algum perÃodo de seu ciclo de vida, lesÃes cariosas pode ser medido atravÃs de uma anÃlise complexa que utiliza os fatores determinantes da saÃde e outros fatores especÃficos do processo saÃde-doenÃa. A partir do diagnÃstico precoce da doenÃa cÃrie, assim como anÃlise dos fatores determinantes auxiliares da avaliaÃÃo do risco de cÃrie, o tratamento torna-se mais simples, menos invasivo e de menor custo. Tem sido bastante difundida ultimamente a utilizaÃÃo de lectinas para diagnÃstico e prevenÃÃo de algumas doenÃas. Em se tratando da doenÃa cÃrie, ao longo de muitos anos, essa estratÃgia tem sido explorada ainda de forma incipiente. Nesta perspectiva, o objetivo deste trabalho foi investigar as potencialidades biotecnolÃgicas da lectina de alga marinha da espÃcie de Hypnea musciformis (HML) aplicadas Ã odontologia. Trata-se de um estudo explicativo-experimental de abordagem quantitativa atravÃs de questionÃrio de saÃde e anÃlises estatÃsticas de dados. A pesquisa faz referÃncia Ã uma anÃlise comparativa de testes salivares e atividade cariogÃnica em escolares de 12 anos de idade e a busca avaliar as potencialidades biotecnolÃgicas da lectina de alga marinha da espÃcie de Hypnea musciformis (HML) no diagnÃstico e prevenÃÃo de cÃrie dentÃria. A Ãrea de concentraÃÃo deste estudo MacromolÃtulas / AplicaÃÃo BiotecnolÃgica de Lectinas. No presente estudo, foram comparados os resultados obtidos atravÃs da aplicaÃÃo de exame clÃnico convencional para cÃrie e testes salivares de atividade cariogÃnica apontados pelo programa CARIOGRAMÂ em associaÃÃo com anÃlises laboratoriais com a utilizaÃÃo de lectinas especÃficas. A partir deste estudo, concluiu-se que, em se tratando do uso de lectinas como potencial biotecnolÃgico para a prevenÃÃo e diagnÃstico de cÃrie dentÃria, percebeu-se que hÃ reconhecimento de glicoconjugados presentes na saliva de pacientes de alto e baixo risco observados em padrÃo de fluorescÃncia. Os resultados demonstram que a lectina testada tem a capacidade de interferir no crescimento bacteriano de forma negativa, sendo estatisticamente significante (p<0,01) em relaÃÃo aos grupos controle de salina e BSA. Entretanto estudos de inibiÃÃo da formaÃÃo de biofilmes microbianos utilizando a HML estÃo sendo programados, para assim avaliar a possibilidade de utilizaÃÃo dessas proteÃnas como insumos biotecnolÃgicos a ser utilizados para prevenÃÃo da cÃrie dentÃria. Pode-se ainda afirmar que os resultados obtidos pelo uso de HML na atividade antibacteriana foram promissores, mostrando que esta lectina apresentou atividade antibacteriana mesmo em quantidades muito pequenas. Quanto ao uso destas proteÃnas na formaÃÃo e desenvolvimento de biofilmes, nÃo houve padrÃo caracterÃstico.

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Mammitzsch, Jens. "Untersuchungen zum Einsatz von ultrahochmolekularen Polyethylenfasern in Seilen für die Fördertechnik". Doctoral thesis, Universitätsbibliothek Chemnitz, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:ch1-qucosa-159603.

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Seile aus synthetischen Fasern gewinnen zunehmend an Bedeutung für fördertechnische Anwendungen. Wegen ihrer geringen Dichte und Biegesteifigkeit sowie den gleichzeitig mit Stahl vergleichbaren Zugfestigkeiten, haben sich Seile aus ultrahochmolekularen Polyethylenfasern (UHMW-PE) in vielen Anwendungen in der Seefahrt und im Offshore-Bereich durchgesetzt. Die grundsätzliche Eignung solcher Seile für technische Anwendungen, wie z.B. Kräne, Aufzüge, Windenanwendungen, wurde in wissenschaftlichen Studien bereits nachgewiesen. In der vorliegenden Arbeit werden hochfeste Polyethylenfasern verschiedener Hersteller daraufhin untersucht, in wie weit diese durch ihre Eigenschaftsprofile ebenfalls grundsätzlich für technische Anwendungen mit auftretenden Biegewechselbelastungen geeignet sind und welche Anwendungspotentiale sie bieten. Beginnend mit einem kurzen geschichtlichen Abriss über die Entwicklung von synthetischen Polymerfasern und den Einsatz der Fasern in Seilen für technische Anwendungen, sollen grundlegend die Herstellungsverfahren und Eigenschaften von Garnen aus ausgewählten UHMW Polyethylen verglichen werden. Im weiteren Verlauf werden Faserseile aus den gewählten Fasern hinsichtlich Zugfestigkeit, Biegewechselverhalten und Eignung zum Thermofixieren untersucht. Auftretende Effekte werden analysiert und auf die Eigenschaften der Fasern bzw. Garne zurückgeführt. Eine vergleichende Betrachtung der Materialkosten als Teil der gesamten Herstellungskosten der Seile bildet den Abschluss der Arbeit
This thesis covers investigations on the properties of ultrahigh-molecular-weight (UHMW) polyethylene fibers for use of manufacturing braided fiber ropes for conveyor and hoisting applications. The importance of synthetic fibres for conveying applications has increased during the last years. Due to the low density and bending stiffness at a strength that is comparable to steel, ropes made from high-strength UHMW polyethylene fibres have found their ways into several shipping and off-shore applications. The basic aptitude of UHMW polyethylene fibres to be used in applications like cranes, elevators and winch applications has already been proven in scientific works. Within this thesis, selected UHMW polyethylene fibres are investigated to determine how much their differing property profiles do influence their aptitude to be used in technical applications with cyclic bending loads and for which potentials for fields of application they might be appropriate. Starting with a short overview on the history of synthetic fibres and the use of such fibres in technical applications, manufacturing processes and properties of these fibres are to be compared. Further, fibre ropes, made from the selected fibres, are going to be investigated concerning their tensile strength, behaviour in cyclic bend-over-sheave tests and their aptitude to increase the strength by thermosetting. Occurring effects are going to be analysed and related to the properties of the yarns. A competitive view on the prices of the yarns regarding their portion of the total costs of rope manufacturing is finalising this work

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Richtr, Vít. "Optimalizace rozmístění zboží v prodejnách". Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-150221.

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The diploma work is focused on a store layout optimization and the related areas. The work is divided into four parts where the first three parts described the theoretical thesis. The first chapter is about the marketing theory -- a customer's behavioral rules in a retail store and a correct store layout. The second chapter is based on the logistics theory and describes the methods of a range of goods categorization according to the different views. The third chapter is focused on the operations research theory and the assignment problem's models. The last chapter describes in detail a real example workflow -- the store layout optimization for Linde Gas Company. The objective is identification of the lucrative areas in the stores, the sold range of goods analysis and the creation of the store layout which will respect a customer's behavioral rules and which will also promote the sales of the selected goods.

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Freimanis, Graham L. "The detection and role of human endogenous retrovirus K (HML-2) in rheumatoid arthritis". Thesis, University of Wolverhampton, 2008. http://hdl.handle.net/2436/41777.

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Human endogenous retroviruses are the remnants of ancient retroviral infections present within our genome. These molecular fossils show similarities with present day exogenous retroviruses but act as typical Mendelian elements that are passed vertically between generations. Despite being repeatedly linked to a number of autoimmune diseases and disorders, no conclusive proof has been identified. Rheumatoid arthritis (RA) is one such disease which has been associated with an increase in HERV expression, compared to controls. In order to elucidate a clear role for HERVs in RA pathogenesis, autoantigens implicated in disease pathogenesis were scanned for sequence homology to retroviral genes. Such epitopes would induce antibodies cross reactive with host proteins, resulting in disease. Short peptides mimicking these regions were synthesised and the prevalence of anti-HERV antibodies was determined in RA patients and disease controls. Additionally, a novel real-time Polymerase Chain Reaction (PCR) assay was developed to accurately quantify levels of HERV-K (HML-2) gag expression, relative to normalised levels of housekeeping gene expression. Both serological and molecular assays showed significant increases in HERV-K (HML-2) activity in RA patients compared to disease controls with CD4+ lymphocytes harbouring the highest activity. The real-time assay was also used to determine whether factors within the synovium could modulate HERVs, resulting in their upregulation. Exogenous viral protein expression and pro-inflammatory cytokines were shown to exert a significant modulatory effect over HERV-K (HML-2) transcription. From this data, it is clear that RA patients have increased levels of HERV-K (HML-2) gag activity compared to controls. Despite this it is likely that factors within the synovium such as exogenous viral expression and pro-inflammatory cytokines also influence HERV-K (HML-2) transcription possibly contributing to a role of bystander activation, i.e. being influenced by external factors, rather than actively contributing to disease processes. The exact role of HERVs in RA pathology remains elusive; however this research proposes several mechanisms by which HERV-K (HML-2) may contribute to disease.

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Kulkarni, Chaitrali S. "Novel formulations of a poorly soluble drug using the extrusion process". Thesis, University of Bradford, 2013. http://hdl.handle.net/10454/7334.

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Hot melt extrusion has attracted recent interest from the pharmaceutical industry and academia as an innovative drug delivery technology. This novel technique has been shown to be a viable and robust method for preparing different drug delivery systems including pellets, implants, tablets, capsules and granules. The aim of this research was to understand hot melt extrusion processing and explore its pharmaceutical applications. Two applications of hot melt extrusion (HME) have been investigated to improve the properties of poorly soluble thermolabile drugs; polymeric solid dispersions and solid state polymorphic transformation. HME is a solvent free, continuous and readily scalable technique which is increasingly being considered as a viable alternative to conventionally used batch techniques. However, the high temperature and shear forces imparted by the extrusion process can limit its applications with heat sensitive active pharmaceutical ingredients (APIs). Artemisinin was selected as a model drug which being thermolabile in nature and possesses processing challenges to processing HME. A low Tg amphiphillic copolymer, Soluplus® was selected as a matrix material. Drug-polymer compatibility was studied using rotational rheometry and thermal characterisation. The drug was found to be completely dissolved within the polymer, although some discolouration of the mixture was observed, indicating degradation of the API. The addition of a small percentage of citric acid to the formulation was found to prevent this degradation by increasing the pH. The dissolution profile of the formulation was approximately five times higher compared to that of the pure drug. The pharmacokinetic study was carried out using Albino rats to calculate bioavailability. The area under plasma concentration time curve (AUC0-24hr) and peak plasma concentration (Cmax) were four times higher for the prepared solid dispersion compared to that of pure artemisinin. Extruded solid dispersions were found to be amorphous in nature and maintained stability for 2 years. A second route to improving the solubility of poorly soluble APIs was also investigated. It was found that under carefully controlled conditions, high temperature extrusion (HTE) could be used to achieve polymorphic transformation with a number of APIs. This solvent-free continuous process was demonstrated with artemisinin, piracetam, carbamazepine and chlorpropamide. Artemisinin was used as a detailed case study of stability, solvent mediated transformation and mechanism of polymrophic transformation during extrusion, using computational modelling and model shear flows. At high temperature, phase transformation from orthorhombic to triclinic crystals was found to occur via the vapour phase. Under mechanical stress the crystalline structure was disrupted, leading to new surfaces being continuously formed and exposed to high temperatures; thus accelerating the transformation process. Polymorphic transformation during HTE was found to comprise three stages; i) preheating and conveying; ii) vapour phase transformation and size reduction and iii) continuous transformation and agglomeration. The triclinic form showed four times greater dissolution rate as compared to the orthorhombic form. The triclinic form showed two fold increase in bioavailability in Albino rats.

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Linder, Tobias. "Förbättring av leveranssäkerhet inom processindustrin med hög mix, låg volym". Thesis, Mälardalens högskola, Akademin för innovation, design och teknik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-44191.

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Syftet med arbetet är att belysa problematiken med hur företag inom processindustrin med långa ledtider kan bli mer flexibla i sin försörjningskedja. Detta tillsammans med en bred produktportfölj som skapar en utmaning med hög mix av produkter med låga volymer. Studien avser att hitta lösningar för att planera och höja leveranssäkerheten i dessa typer av verksamheter. Utifrån detta formades följande forskningsfrågor: Hur kan leveranssäkerheten mot kunderna höjas? Hur kan organisationer med ett brett produktsortiment och låga volymer öka sin flexibilitet mot marknaden? Hur kan produktionen planeras så att ledtiderna reduceras men flexibiliteten ökar? Metod och forskningsansats: För att besvara frågeställningarna har en litteraturstudie genomförts på området utformning av flexibla försörjningskedjor och hög mix, låg volym (HMLV). En fallstudie har genomförts inom processindustrin som har en brett produktsortiment med låga volymer. Fallstudien har bestått av att granska verksamheten genom en nulägesanalys och se vilka faktorer som påverkar leveranssäkerheten. I studien har datainsamling genomförts där data ur affärssystemen har exporterats och analyseras genom kvantitativa metoder. Resultat: Studien har identifierat ett flertal osäkerheter som påverkar hur prognoser genereras och hur verksamheten planeras hos fallföretaget. Genom osäkerheter både från leverantören av råmaterial och när det kommer till kapacitet finns det många faktorer som påverkar leveranssäkerheten till kund. För att klara osäkerheter i försörjningskedjan bättre har fokus lagts på att skapa ett bättre flöde genom att hitta flaskhalsar och planera utifrån verkligheten. Studien tar upp fördelar och nackdelar med lager och hur ett företag som enbart använder sig av en leverantör kan förhålla sig till variationer i dels sin egen produktion men även hos sin leverantör. Implikationer: Arbetet uppfyller syftet genom att besvara de frågeställningar som finns och belyser de utmaningarna som tillkommer vid hög mix och låga volymer. Genom att identifiera och lyfta upp flaskhalsarna går det att öka kapaciteten. I en verksamhet med HMLV kan paretoprincipen eller ABC-analys användas för att identifiera de stora produktgrupperna för att sedan implementera leanfilsofi på dessa produkter. För att öka leveranssäkerhet i en verksamhet med stora variationer behövs någon typ av lager i form av säkerhetslager eller supermarket. Rekommendationer: För att uppnå en högre leveranssäkerhet behövs verktyg som är anpassade för den specifika verksamheten och som tar hänsyn till den komplexitet som råder. Nyckelord: Försörjningskedja, agil försörjningskedja, kundorderstyrd, produktionsplanering, kapacitet, riskhantering, HMLV, säkerhetslager, supermarket, theory of constraints, flaskhalsar.

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Thomas, William C. "Instructional requirements for using the HML and NRR methods for estimating protected exposure levels under hearing protectors". Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-12232009-020645/.

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21

Kehr, Sandra. "Untersuchung der Expression des HERV-K(HML-2)-Gens np9 in verschiedenen Tumorentitäten und Analyse der transkriptionell aktiven Proviren". Giessen : VVB Laufersweiler, 2008. http://d-nb.info/988284340/04.

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22

Capps, Eric R. "The Relationship Between Mineral Nutrition and Late-Season Bunch Stem Necrosis of Cabernet Sauvignon (Vitis vinifera L.) Grapevines". Thesis, Virginia Tech, 1999. http://hdl.handle.net/10919/31800.

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Late-season Bunch Stem Necrosis (BSN) is observed as a necrosis of the cluster stem (rachis) that leads to shriveling of berries on the affected portion of the cluster. Field experiments were conducted over three years at two vineyards in northern Virginia to examine relationships between specific nutrients and the incidence of BSN of Cabernet Sauvignon grapevines. Nutrients, used alone or in combination, included nitrogen, magnesium, and calcium. During the 1997 and 1998 seasons at Leesburg vineyard, applications of nitrogen, magnesium, and calcium produced little change in bloom-time petiole mineral concentration. Fertilizer treatments appeared to have no effect on BSN incidence, but the incidence of BSN was less than or equal 1% in the control plots each year. During the 1996 season at Winchester vineyard, bloom-time leaf petiole and vÃ©raison rachis nitrogen concentration of unfertilized (control) vines were 0.80% and 1.16%, respectively. The corresponding control BSN incidence was 41% at harvest time. Application of nitrogen fertilizer at 112 kg/ha actual nitrogen increased bloom-time leaf petiole and vÃ©raison cluster stem nitrogen concentration to 1.85% and 2.18%, respectively. The corresponding BSN incidence was reduced to 14% at harvest time. BSN symptoms were not as pronounced during the 1997 season; however, all treatments, including the control plots, had elevated nitrogen levels in 1997. During the 1998 season, bloom-time leaf petiole and vÃ©raison rachis nitrogen concentration of unfertilized vines were 0.88% and 0.98%, respectively. The corresponding BSN incidence was 23% at harvest time. Application of nitrogen fertilizer again increased bloom-time leaf petiole and vÃ©raison rachis nitrogen concentration to 1.18% and 1.34%, respectively. Corresponding BSN was reduced to 3% at harvest time. Magnesium and calcium had no impact on BSN incidence; however, BSN symptoms were reduced when either was combined with nitrogen fertilizer. The relationship between mineral nutrition and BSN incidence at Leesburg was inconclusive. The BSN of Cabernet Sauvignon at Winchester was, however, positively associated with depressed bloom-time petiole total nitrogen concentrations. VÃ©raison rachis analysis consistently revealed an increase in nitrogen concentration due to application of nitrogen fertilizer. VÃ©raison tissue analysis may be a good diagnostic tool of vine nitrogen status. Magnesium and calcium appeared not to be involved in the disorder. The results illustrate that BSN-prone vineyards should be individually examined for nutrient imbalance or other stresses that may be contributing to BSN.
Master of Science

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23

Kim, Eun-Hae. "Maintaining Copper Homeostasis - Molecular Studies on Bacterial Copper Transporters". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/205232.

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Bacteria have evolved sophisticated cellular transport mechanisms to maintain metal homeostasis to not only utilize metals as important cofactors but also to evade the toxicity of these ions. The delicate balance is maintained by several homeostatic mechanisms that range from active cytoplasmic export, modification, sequestration, and periplasmic detoxification of toxic metals to the extracellular milieu. One mechanism involves active periplasmic extrusion of toxic substrates via a transmembrane spanning tripartite protein complex. The mechanism of substrate binding and subsequent efflux has yet to be elucidated. However, genetic, comparative genomic, biochemical, and functional analyses of the components of the heavy-metal efflux family have allowed the development of proposed models for a substrate transport pathway. The goals of this research were to identify the roles these systems play and to further characterize these systems on a molecular level to ultimately understand the mechanism of substrate transport. Elucidating a transport pathway in metal transporters allows for the development of a revised working model, which ultimately can have implications for antimicrobial drug development.

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Nordström, Maria, e Helena Pettersson. "Hållbart medarbetarskap Bara ett jobb eller brinnande engagemang? : En fallstudie med fokus på medarbetarskapet i verksamheter med högt hållbart medarbetarengagemang (HME)". Thesis, Mittuniversitetet, Institutionen för kvalitets- och maskinteknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-42969.

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Enligt en studie som Gallup (2017) genomfört är det endast 14 % av alla medarbetare i Sverige som upplever aktivt engagemang i förhållande till sitt arbete. Detta skapar en negativ påverkan ur en ekonomisk aspekt men även för arbetsmiljön. Med detta som utgångspunkt var syftet med den här studien att undersöka samband mellan SKR:s mätverktyg för hållbart medarbetarengagemang och vad forskningen menar har störst påverkan på motivation. Vidare avsåg studien även att studera kännetecken för medarbetarskap i verksamheter med högt engagemangsindex och se hur detta kunde mätas. I teorikapitlet lyftes teori kring kvalitetsutveckling, medarbetarskapet utifrån Velten et al. (2017) tre pelare, som anses vara grunden för arbetsglädje och avslutningsvis de faktorer som enligt forskning anses ha störst inverkan på motivation (mening, självbestämmande kompetens och inflytande). Urvalet för studien var arbetsgrupper som uppmätt högt värde på engagemangsindex 2020. Studien var av designen fallstudie och har använt flera metoder i datainsamlingen. En kvalitativ del av studien genomfördes genom en granskning av HME - modellens index för hållbart medarbetareengagemang (HME) och fyra intervjuer, i den kvantitativa delen gjordes en enkätstudie. Av resultatet framkommer att tre av sex påståenden i mätverktyget HME inte anses ha stöd i forskning kring motivation. Medarbetarskapet i verksamheter med högt HME kan sammanfattas genom tre huvudområden med två till fyra delområden. Studiens slutsats var att dessa kännetecknas av faktorer som kan knytas till Velten et al. (2017) tre pelare men även till de faktorer som enligt forskning har störst påverka på motivation. Den kvalitativa studien valideras genom enkätstudien som också visar att medarbetarskapet kan mätas genom det verktyg som studien utvecklat.
According to a study by Gallup (2017), only 14% of all employees in Sweden experience engagement in relation to their work. This creates a negative impact from an economic aspect but also on the work environment. With this as a starting point, the purpose of this study was to investigate the relationship between SKR's measurement tool for sustainable employee engagement (HME) and what the research believes has the most significant impact on motivation. Furthermore, the study also intended to study the characteristics of employees in companies with a high commitment index and see how this could be measured. The theory chapter highlights the theory of quality development, the collaboration based on Velten et al. (2017) three pillars, which are considered to be the basis for job satisfaction and finally, the factors that, according to research, are considered to have the most significant impact on motivation (meaning, self-determining competence and influence). The sample for the study was working groups that measured high value on the engagement index 2020. The study was by design a case study and has used several methods in the data collection. A qualitative part of the study was conducted by reviewing the HME model's index for sustainable employee engagement (HME) and four interviews. In the quantitative part, a questionnaire study was conducted. The results show that three out of six statements in the measurement tool HME are not considered to support research on motivation. Employeeship in organizations with a high HME can be summarized through three main areas with two to four sub-areas. The study concluded that these are characterized by factors that can be linked to Velten et al. (2017) three pillars and the factors that, according to research, have the most significant influence on motivation. The qualitative study is validated through the questionnaire study, which also shows that employeeship can be measured through the study's tool.

2021-06-06

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Hammarström, Emilia, Elsa Hillberg, Staffan Johnson e Adan Larsson. "Kategorisering av sortiment för ökad servicenivå : En fallstudie på Back on Track AB". Thesis, Högskolan i Borås, Akademin för textil, teknik och ekonomi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-25582.

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Abstract (sommario):

Rapporten utgår från olika kategoriseringsmetoder för att på sikt öka servicenivån. Fallföretaget har under den senaste tiden expanderat, vilket bidragit till att de inte längre kan möta efterfrågan. De inköpsstrategier som tidigare använts är inte längre tillräckliga för de nya försäljningsvolymerna. Verksamheten har långa ledtider vilket ställt högre krav på inköpsstrategin och planering. Med hjälp av empiri, studentlitteratur, facklitteratur och observationer redogör rapporten för hur verksamheten kan förbättras genom en fallstudie. Med hjälp av observationer vid besöket hos fallföretaget kunde kartläggning av verksamheten och dess strategier slutföras, vilket ledde fram till rapportens syfte och frågeställningar. Genom att strukturera datan efter de olika metoderna, tillsammans med visuella hjälpmedel som diagram och grafer kunde resultatet gestaltas. Därefter analyserades resultatet för att dra slutsatser kring om det finns någon korrelation mellan teorin och rapportens resultat. Analysen lyfter fram hur kategorisering av metoderna används för att öka servicenivån. Därutöver analyseras för- och nackdelarna med de olika metoderna. Likaså behandlar rapporten vilken kategorisering som är mest lämplig i nuläget samt för framtiden. Det förekommer även diskussioner om olika prognosmodeller och hur man bör gå tillväga för att förbättra lagerstyrningen och höja servicenivån. Validiteten och reliabiliteten av rapporten diskuteras också för att kunna identifiera hur tillförlitlig rapporten är samt om den faktiskt mäter det den önskas mäta. Rapporten redogör för att FSN är den bästa kategoriseringen för fallföretaget. Genom att basera inköpen på prognosmodeller kan verksamheten hitta lämpliga orderkvantiteter. Den framtida inköpsstrategin baseras på kvantitativa modeller vilket bygger på historisk data. Utöver framtida inköpsstrategier föreslås hur verksamheten bör prioritera sina olika produkter för att på sikt höja servicenivån. Slutligen sammanfattas alla rekommendationer för en enklare förståelse av rapportens slutsats.
The report is based on various categorization methods that have been developed to increase the level of service in the long term. The case company has recently expanded, which has contributed to them no longer being able to meet the demand. The purchasing strategies they previously used are no longer sufficient for the new sales volumes. With long delivery times from factories in Asia, the intervals between stock refills are getting longer, which requires foresight. Using empirical data, student literature, non-fiction and observations, the report explains how the business can be improved through a case study. Calculations, formulas and tables are based on student literature and scientific articles. By starting from proven theories, the business's inventory management can be improved. With the help of observations during the visit to the case company, mapping of the business and its strategies could be completed, which led to the report's purpose and issues. By structuring the data according to the different methods, together with visual aids such as diagrams and graphs, the result could be shaped. The results were then analyzed to draw conclusions about whether there is any correlation between the theory and the report's results. The analysis highlights how categorization of the methods is used to increase the level of service. In addition, the advantages and disadvantages of the different methods are analyzed. Discussion about which categorization is most suitable in the current situation and for the future is then highlighted. There are also discussions about different forecast models and how to proceed to improve inventory management and raise the level of service. The validity and reliability of the report are also discussed in order to be able to identify how reliable the report is and whether it actually measures what it wishes to measure. The report states that FSN is the best categorization for the fall company. By analyzing forecast models based on demand from the categorization, a purchasing strategy for the company in the future is estimated. The future purchasing strategy is based on quantitative models, which is based on historical data that the case company currently lacks. In addition to future purchasing strategies, working methods with new products as well as improvement proposals with the work of categorization models are proposed. Finally, all recommendations are summarized for a simpler understanding of the report's discoveries.

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26

Hajric, Amina, e Kajsa Larsson. "Utvärdering av CAPM och Fama & French-trefaktormodellen : en studie på den svenska marknaden". Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-17214.

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Det är sedan länge känt att det finns en positiv korrelation mellan risk och avkastning. Investerare och bolag kan välja mellan flera olika prissättningsmodeller för att förutspå priset på en aktie. Forskare har, med den kända enfaktormodellen CAPM som utgångspunkt, utvecklat en modell som tar hänsyn till mer än bara marknadsfaktorn. Detta resulterade i framtagandet av Fama & French-trefaktormodellen (FF3) som även inkluderar storleksfaktorn SMB samt värdefaktorn HML. Syftet med studien är att utvärdera två prissättningsmodeller, CAPM och FF3, för att kunna bedöma deras prestanda vid värdering av förväntad avkastning. Tidigare forskning, inom området för nämnda modeller, berör ofta internationella marknader samt modellernas prestanda för portföljer. Vår studie utförs på utvalda enskilda svenska aktier inkluderade på Stockholmsbörsens Large Cap för januari år 2011 till december år 2015, genom att replikera tidigare forskning gjord av Bartholdy & Peare (2005). Utvalda bolag analyseras efter regressioner för modellerna för att kunna utvärdera dessa var för sig, samt för att se om FF3 har en högre justerad förklaringsgrad än CAPM för enskilda svenska aktier. Resultatet av studien visar att både CAPM och FF3 är applicerbara för utvalda enskilda svenska aktier. Ställs FF3 i förhållande till CAPM föreligger skillnad i justerad förklaringsgrad, dock är den ytterst marginell. Sammanfattningsvis bidrar studien med kunskapen om att CAPM och FF3 går att applicera på enskilda svenska aktier, men att det inte föreligger någon större skillnad i val av dessa två modeller.
Investors and companies can choose between multiple pricing models to predict the price of shares. With the known one factor model CAPM, researchers have developed a model that consider more than just the market factor. This resulted in the creation of the Fama & French three factor model (FF3), which also includes the size factor SMB and the value factor HML. The purpose of the study is to evaluate two pricing models, CAPM and FF3, to assess their performance when evaluating expected returns. Previous research often deal with international markets and model performance of portfolios. We study selected individual Swedish shares for January 2011 to December 2015 by replicating previous research by Bartholdy & Peare (2005). Selected companies are analysed by regressions for the models to be able to evaluate these separately, and to see if FF3 has a higher degree of explanation than CAPM for individual Swedish shares. The result of the study shows that both CAPM and FF3 are applicable for selected individual Swedish shares. There is a difference in the adjusted degree of explanation between the models but it is marginal. In conclusion, the study contributes with the knowledge that CAPM and FF3 can be applied to individual Swedish shares, but there is no major difference in the choice of these two models.

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Kehr, Sandra [Verfasser]. "Untersuchung der Expression des HERV-K(HML-2)-Gens np9 in verschiedenen Tumorentitäten und Analyse der transkriptionell aktiven Proviren / eingereicht von Sandra Kehr". Giessen : VVB Laufersweiler, 2008. http://d-nb.info/989050599/34.

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Riscifina, Vanessa Bernardi Ortolan. "Uma investigação da reação dos retornos das ações às divulgações de resultados de empresas de capital aberto, no Brasil e no México". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/96/96132/tde-17042008-110045/.

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Esse estudo visa testar a eficiência informacional dos mercados acionários brasileiro e mexicano, através do desenvolvimento de um estudo de eventos. Para viabilização do estudo, o mercado brasileiro será representado pela BOVESPA - Bolsa de Valores de São Paulo e o mercado mexicano pela BMV - Bolsa Mexicana de Valores. Especificamente, esses mercados serão representados pelas ações de empresas que participaram da composição das carteiras teóricas dos Índices IBOVESPA e IpyC (Índice de Precios y Cotizaciones) durante todo o período compreendido entre Janeiro de 2001 e Janeiro de 2006. Foram analisadas as reações dos retornos das ações nesses mercados nos dias próximos às datas das divulgações de resultados trimestrais pelas empresas em busca de evidências de ineficiências. Os resultados encontrados mostraram indícios de eficiência informacional quando as empresas foram consideradas individualmente e indícios de ineficiência informacional quando considerada carteira toda.
This study aims to test the informational efficiency of the Brazilian and Mexican stock markets, through the development of an event study. For this purpose, BOVESPA, the Sao Paulo Stock Exchange will represent the Brazilian stock market while the Mexican Stock Exchange (BMV) will represent the Mexican stock market. Specifically, these markets will be represented by the company stocks that participated of the composition of their stock market indexes, IBOVESPA (BOVESPA Index) and IPyC (Mexican Stock Exchange Index), during the period of January 2001 through January 2006. Stock prices were analyzed for the days around the quarterly results release dates, searching for inefficiency evidence in these markets. The results show signs of information-efficiency when considering each company and information inefficiency when considering the market portfolio.

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Amaresh, Amaresh, e Kuriachen Oooramvely. "Standardization in a High Mix Low Volume Company : A Case Study". Thesis, Tekniska Högskolan, Jönköping University, JTH, Produktionsutveckling, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-49399.

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The market has been evolving from mass production towards mass customization, which has increased the complexity level for the companies. Unlike in mass production companies where the tasks are routine and standardized, the mass customization types of companies have a varied work demand which makes the work environment complex. These types of mass customization companies are known as High Mix Low Volume type of companies basically because of their characteristics of having a high mix in products and comparatively low volume production. This thesis research was done with DEWTON INDUSTRIES, Kochi in India. Although product variety and complexity has been answered using technology development and modularization in the previous studies, there has been less focus given to reducing the complexity from the production process point of view. It is also evident that there is limited literature and research done regarding the standardization in High Mix Low Volume type companies both in the academia and in the industry. Hence, understanding the problems regarding standardization in a High Mix Low Volume company and how to handle them has been of a major importance at this point of time. The purpose of the research is to see how standardization can be increased in HMLV companies. The research approach used here was the case study to collect the necessary data to achieve the results. The data collection techniques used were interviews, observations and literature review, which gave the guidelines and suggested solutions to the identified problems related to standardization in High Mix Low Volume company in the production department. The findings from the research suggest that standardization in HMLV production is very important for the companies in their current market demands. This is because standardization has a major effect on the quality of end products, production lead time, working standards of employees in the production department and design department. Various problems can occur, and only standardized procedures can solve these problems. It has been well exemplified in this thesis work, how these standardized procedures can increase the quality of the products, increase production speed, and also profit for the company. This research paper can be used as a guideline by other HMLV companies, while they plan to implement standardization in the production department. To the best of our knowledge this research was one of a kind in this particular field of study and also provides a base for in-depth research on each identified problem.

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Hasler, Mathias. "Essays in Empirical Asset Pricing:". Thesis, Boston College, 2021. http://hdl.handle.net/2345/bc-ir:109083.

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Thesis advisor: Jeffrey J.P. Pontiff
My dissertation includes three chapters on the value premium. In the first chapter, I study whether seemingly innocuous decisions in the construction of the original HML portfolio (Fama and French, 1993) affect our inference on the value premium. I find that the value premium is dramatically smaller than we thought. In sample, the average estimate of the value premium is 0.09% per month smaller than the original estimate of the value premium. Out of sample, however, the difference is statistically insignificant. The results suggest that the original value premium estimate is upward biased because of a chance result in the original research decisions. In the second chapter, I propose an estimate for intangible assets and growth opportunities and examine if this estimate improves book-to-market equity as a measure of value. I find that portfolios sorted on book equity plus the estimate to market equity have lower returns than portfolios sorted on book-to-market equity. The results suggest that intangible assets and growth opportunities diminish book-to-market equity as a measure of value because investors value intangible assets and growth opportunities in an overly optimistic way. In my third chapter, I simultaneously study nine explanations of the value effect to better understand what the dominant value explanation is. I find that duration accounts for most of the value effect and that the eight other explanations account for a negligible part of it. The results suggest that duration is the dominant explanation of the value effect
Thesis (PhD) — Boston College, 2021
Submitted to: Boston College. Carroll School of Management
Discipline: Finance

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VASCONCELOS, Wellyton Silva. "Determinação de metais pesados em méis de abelha de algumas mesorregiões do Estado de Pernambuco por voltametria de redissolução anódica". Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/12464.

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Submitted by Danielle Karla Martins Silva (danielle.martins@ufpe.br) on 2015-03-13T14:33:07Z No. of bitstreams: 2 DISSERTAÇÃO Wellyton Vasconcelos.pdf: 5901517 bytes, checksum: 8d69a53b2f1a2ee6c1261e4b9ee35228 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5)
Made available in DSpace on 2015-03-13T14:33:07Z (GMT). No. of bitstreams: 2 DISSERTAÇÃO Wellyton Vasconcelos.pdf: 5901517 bytes, checksum: 8d69a53b2f1a2ee6c1261e4b9ee35228 (MD5) license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) Previous issue date: 2014
CNPq
O mel de abelha tem uma imagem de ser natural e saudável, entretanto, muitos dos méis consumidos hoje são produzidos em ambientes poluídos por diferentes tipos de contaminação alterando, com isso, suas características mais nobres. Nesse estudo a contaminação por metais pesados tais como Zn, Cd, Pb e Cu é avaliada para 20 amostras de mel de abelha produzidas no estado de Pernambuco utilizando a técnica de voltametria de redissolução anódica de pulso diferencial (DPASV, do inglês Differential Pulse Anodic Stripping Voltammetry) em eletrodo de gota pendente de mercúrio (HMDE, do inglês Hanging Mercury Drop Electrode). A formação de compostos intermetálicos entre Zn e Cu na superfície do eletrodo durante a etapa de préconcentração impede a determinação simultânea dos quatro metais na matriz orgânica mineralizada. Para a determinação de Zn utiliza-se uma solução-padrão de Ga(III) e o Cu é determinado em um potencial de deposição menor que o requerido para a redução do Zn, permitindo a determinação dos quatro metais por dois experimentos de DPASV realizados consecutivamente na mesma amostra. As faixas de concentrações de metais pesados encontrados nas amostras analisadas foram de 1,283 – 4,312 mg.g-1 para Zn, 0,168 – 0,645 mg.g-1 para Pb e 0,170 – 1,426 mg.g-1 para Cu. A presença de Cd nas amostras não foi detectada. O método apresentou altos níveis de repetitividade e ausência de viés em concentrações acima de 0,200 mg.g-1. De acordo com esses resultados, observa-se que o mel produzido em Pernambuco é de boa qualidade, embora uma das vinte amostras analisadas tenha apresentado teor de Pb acima do limite estabelecido por legislação vigente. Acredita-se que essa amostra pode ter sido contaminada durante o processo de transporte do mel já que este foi envasado em local distinto do apiário de origem. Para as demais amostras, as concentrações de metais pesados estão dentro dos parâmetros aceitáveis.

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Merriman, Michael Lee. "Systematic Risk Factors, Macroeconomic Variables, and Market Valuation Ratios". Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1224330564.

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Schmitt, Katja [Verfasser], e Jens [Akademischer Betreuer] Mayer. "Identifizierung und Charakterisierung transkribierter Loci der humanen endogenen Retrovirus-Gruppen HERV-K(HML-2) und HERV-W im Kontext von Tumorerkrankungen und Multipler Sklerose / Katja Schmitt. Betreuer: Jens Mayer". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2014. http://d-nb.info/1056907002/34.

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34

Wamara, Jula [Verfasser], Norbert [Akademischer Betreuer] Bannert, Vera [Gutachter] Meyer, Norbert [Gutachter] Bannert e Jens [Gutachter] Kurreck. "Identifizierung einer Rezeptorbindestelle im Hüllprotein des Humanen Endogenen Retrovirus K(HML-2) und weitergehende Analysen der Interaktion des Hüllproteins mit zellulären Rezeptoren / Jula Wamara ; Gutachter: Vera Meyer, Norbert Bannert, Jens Kurreck ; Betreuer: Norbert Bannert". Berlin : Technische Universität Berlin, 2020. http://d-nb.info/1213348560/34.

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35

Walter, M. Astrid. "Herstellung und Charakterisierung von Antikörpern gegen Triacetontriperoxid (TATP)". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16899.

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Die vorliegende Arbeit beschreibt die Herstellung und Charakterisierung der ersten Antikörper gegen Triacetontriperoxid (TATP), einem hoch empfindlichen und unkonventionellen (nicht-kommerziellen) Initialsprengstoff. Entscheidend dafür war die Synthese eines TATP-imitierenden Haptens, welches die typische nonagonale Struktur des TATP mit seinen drei Peroxid- und sechs Methylgruppen nahezu perfekt nachbildet, aber den Vorzug einer zusätzlichen Carboxygruppe zur kovalenten Kopplung an Proteine aufweist. Dadurch konnte das TATP-Hapten an Rinderserumalbumin (BSA) gebunden werden, um ein immunogenes Konjugat zu erzeugen, welches die erfolgreiche Immunisierung zweier Säugetierarten, Maus und Kaninchen, ermöglichte. Der Verlauf der In vivo-Immunisierungen wurde durch die Analyse der Tierseren in regelmäßigen Abständen mittels enzymgekoppeltem Immunoassay (ELISA) verfolgt. Die polyklonalen Antikörper beider Spezies waren ungewöhnlich selektiv gegenüber TATP. Jedoch unterschied sich die Affinität der Antikörper der zwei Spezies um das 5000-fache, wobei die Kaninchenseren den Mausseren überlegen waren. Entsprechend war auch die mit Kaninchenserum erreichbare TATP-Nachweisgrenze von 0.01 µg/L deutlich besser im Vergleich zu 50 µg/L, die mit Mausserum erzielt wurden. Der Messbereich des TATP-ELISA mit Kaninchenserum deckte zudem mehr als vier Zehnerpotenzen ab, wie mittels Präzisionsprofil bestimmt wurde. Die erhaltenen TATP-Antikörper aus Kaninchen stehen damit Anwendungen in Nachweissystemen für die sehr empfindliche Detektion von TATP zur Verfügung, die u. a. in sicherheitsrelevanten Bereichen zum Einsatz kommen könnten. Als erste Anwendung wurde ein TATP-ELISA realisiert, der im Rahmen dieser Arbeit ausführlich optimiert wurde. Außerdem wurden erste Schritte zur Entwicklung eines TATP-Schnelltests (LFA) unternommen. Weitere Biosensoren auf Grundlage der neu entwickelten TATP-Antikörper sind denkbar.
The present work decribes the production and characterization of the first antibodies against triacetone triperoxide (TATP), a highly sensitive and improvised (non-commercial) primary explosive. Crucial to this work was the synthesis of a TATP-related hapten that mimics almost perfectly the typical nonagonal structure of TATP with its three peroxide and six methyl groups. Advantageously, it has an additional carboxylic acid group, which provides a conjugation site for covalent attachment to proteins. Thus, the TATP hapten could be linked to bovine serum albumin (BSA) to produce an immunogenic conjugate, allowing the successful immunization of two different mammalian species, mouse and rabbit. The in vivo immunization progress was followed by periodically analyzing the animals’ sera using enzyme-linked immunosorbent assay (ELISA). The polyclonal antibodies of both species were remarkably selective to TATP. The affinity of these TATP-antibodies was, however, different between the two species, with the rabbit sera showing an affinity about 5000-fold superior than the murine one. Consequently, the TATP detection limit of 0.01 µg/L was considerably better using the sera from rabbit in contrast to 50 µg/L when mouse serum was used. The working range of the TATP-ELISA with rabbit sera covers more than four decades, calculated from a precision profile. The obtained TATP antibodies from rabbit are now available for applications in highly sensitive detection systems for TATP, which could be employed, among others, in security-relevant areas. The first application was the realization of a TATP-ELISA, which was extensively optimized within the course of this work. Furthermore, the first steps towards the development of a lateral flow assay (LFA) targeting TATP were taken, making conceivable further biosensor platforms based on the newly developed TATP antibodies.

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Nordström, Daniel, e Sofia Lindh. "Magic Formula på den svenska aktiemarknaden : Kan en värdeinvesteringsstrategi generera abnormal avkastning på lång sikt?" Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414789.

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Att slå marknaden har varit ett kontroversiellt ämne inom akademin under en väldigt lång tid.Enligt EMH, en grundläggande finansteori, är det inte möjligt att “slå marknaden” under enlång tid utan att ta högre risk. Hedgefond-förvaltaren Joel Greenblatt publicerade år 2006 enformel som ska kunna prestera över marknaden till lägre risk, även långsiktigt, The MagicFormula. Denna studie utvärderar en Magic Formula-portfölj på den svenska marknaden i syfteatt undersöka om den kan generera en abnormal avkastning i perioden år 2000-2020. Dettagenomförs genom en kvantitativ analys. Resultaten visar att Magic Formula-portföljensintercept är signifikant skiljt från 0 i Fama & Frenchs trefaktormodell som inkluderar enmarknads-, storleks- och värdefaktor. Eftersom de riskpremier som testats för inte förklararavkastningen dras slutsatsen att antingen är trefaktormodellen bristfällig, eller så existerar enanomali kopplat till strategin.

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Johansson, Tom-Filip, e Tommi Määttä. "Abnormal Returns of Swedish Equity Funds : Are Managers Skilled or Lucky?" Thesis, Umeå universitet, Företagsekonomi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-56783.

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The fund market has grown substantially during the past decades and the majority of Swedish citizens are invested in funds directly or through pension savings. There is mixed evidence on the performance of Swedish equity funds depending on the method employed and the time period studied. In this study, we set out to estimate abnormal performance using acknowledged methods during a time-period that is both longer and more recent than previous studies. Our sample is survivorship-free and consists of 150 mutual equity funds during January 1993 to December 2011. We use a four-factor model to estimate abnormal performance compared to an index and additional risk factors. We find that the average performance is neutral net of costs and that funds outperform with 1.7 percent before costs, the difference is approximately the average management fee. Over time, we find that the average abnormal performance and the share of funds that have significant outperformance have decreased while the share of significant underperformance has increased. Since the study of fund performance started in the 1960's the twin questions has been; does funds outperform the market and is this a result of pure chance or are managers skilled? Since we observe funds with significant positive and negative abnormal performance, we want to know if the results can attributed to luck or skill. We employ the latest technique, a bootstrap simulation, to test for skill or luck. This is the first study to employ the bootstrap to distinguish skill from luck in sample of Swedish funds. By ranking funds on performance after costs, we find that the performance of the majority of funds can be attributed to skill or "bad skill". The evidence is strongest in the top 95th percentile and above, and from the bottom 50th percentile and below.

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Costa, Tiago Alves. "Novas finanças: um estudo sobre a fragilidade da hipótese de mercados eficientes". Pontifícia Universidade Católica de São Paulo, 2008. https://tede2.pucsp.br/handle/handle/1268.

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The finance science, as all sciences, shows an evolutionary line and according to Kuhn (1970), it is marked by shortly periods of knowledge accumulation. However, according to the author, such periods are inserted with scientific revolutions. In other words, the scientific evolution is stamped by revolutions which abandon oldfashioned paradigm and create new ones. The revolution is followed by a period where the researches are guided by the new paradigm and its purpose is strengthen the own paradigm. In other way, the finance science has today a central paradigm well-known by efficiency market hyperlink (EMH) which was witnessed and adopted by the entire scientific community around the 70 s. And since those times, almost entire research done in finance, mainly until the de 90 s, was leaded and done to validate the EMH. This dissertation attempted to evidence that the finance evolutionary line proposed by Haugen (2000) follows the same principle evidenced by Kuhn (1970), and in the present-day, the EMH find itself in a period which precede the scientific revolution which is called by time crisis by Kuhn (1970). This time crisis could weaken the EMH and open a space to create a new paradigm. This way, the proposal of dissertation is to prove how the revolutionary process will happen in finance too, soon after, to prove what would the candidates more inclined to replace the EMH be as a central paradigm in finance. To do so, this work considered only two candidates: the behavioral finance and the chaos theory. To do this analyze it was used the schooling principles nominated by Mckinley, Mone and Moon (2002). Such authors propose that a thought must display a combination of novelty, continuity, and scope to achieve school status in organizational theory. The purpose of this dissertation is to do a theory ransom which intends to show the fragility of the EMH as a central paradigm that orients the finance researches. The dissertation concludes that the current finance faces a crisis, and in this period, the behavioral finance displays the biggest chance to replace the EMH in the near future, however, the chaos theory provides the bigger promise considering a far future
A ciência das finanças, como toda ciência, apresenta uma linha evolutiva que de acordo com Kuhn (1970) é marcada por períodos de breve acumulação de conhecimento. Porém, de acordo com o autor, tais períodos são intercalados com revoluções científicas. Em outras palavras, a evolução científica é marcada por revoluções que abandonam antigos paradigmas e criam novos. Posteriormente à revolução, segue se um período onde as pesquisas são guiadas pelo novo paradigma com o propósito de fortalecer o próprio paradigma. De outra forma, a ciência financeira possui hoje um paradigma central conhecido como a hipótese de mercados eficientes (HME) que foi reconhecida e adotada pela comunidade científica por volta da década de 70. E desde aquela época, quase toda pesquisa feita na área, principalmente até a década de 90, foi guiada, e feita para validar e fortalecer a própria HME. Nesse sentido, este trabalho procurou evidenciar que a linha evolucionária das finanças proposta por Haugen (2000) segue o mesmo princípio evidenciado por Kuhn (1970), e que no momento atual, a HME encontra-se em um período que antecede a revolução científica e que é chamado de período de crise por Kuhn (1970). Esse período de crise, que antecede as revoluções, poderia enfraquecer a HME e abrir espaço para a criação de um novo paradigma. Sendo assim, o trabalho também propõe a evidenciar como que o processo de revolução poderá acontecer em finanças, e em seguida, também propõe quais seriam os candidatos mais propensos a substituir a HME como paradigma central em finanças. Para tanto, o trabalho considerou apenas dois candidatos: as finanças comportamentais e a teoria do caos. Para fazer tal análise, foram utilizados os princípios de escolarização propostos por Mckinley, Mone e Moon (2002). Tais autores propõem que um pensamento tem que possuir três características (novidade, continuidade e escopo) para ser considerado uma escola em teoria organizacional. O propósito do trabalho é de um resgate teórico básico que procura evidenciar a fragilidade da HME enquanto paradigma principal norteador das pesquisas em finanças. Assim sendo, o trabalho conclui que as finanças atuais enfrentam uma crise, e que nesse período, as finanças comportamentais apresentam a maior chance de substituir a HME em um futuro próximo, porém, a teoria do caos fornece uma promessa maior considerando um futuro mais distante

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39

Monchy, Sébastien. "Organisation et expression des gènes de résistance aux métaux lourds chez Cupriavidus metallidurans CH34". Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210706.

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Cupriavidus metallidurans CH34 est une béta-protéobactérie, résistante aux métaux lourds, isolée des sédiments d'une usine de métallurgie non-ferreuse en Belgique.

Le génome de cette bactérie contient un chromosome (3.6 Mb), un mégaplasmide (2.6 Mb) et deux plasmides pMOL28 (171 kb) et pMOL30 (234 kb) déjà connus pour porter des gènes de résistance aux métaux lourds.

Nous avons d'abord fait le catalogue des gènes impliqués dans la résistance aux métaux lourds et, ensuite, cherché à mesurer leur expression par deux approches transcriptomiques :RT-PCR et puces à ADN.

L'analyse du génome montre au moins 170 gènes relatifs à la résistance aux ions métalliques localisés sur les 4 réplicons, principalement sur les deux plasmides. Ces gènes codent essentiellement pour des systèmes d'efflux tel que les HME-RND (transport chimioosmotique avec flux de protons à contresens), les ATPases de type P ou encore pour le système de résistance aux ions Cu(II). Dans le génome de C. metallidurans, nous avons identifié 13 opérons qui codent pour des systèmes HME-RND, seuls trois, localisés sur les plasmides, sont surexprimés en présence de métaux lourds. Huit gènes codent pour des ATPases de type P, dont deux appartiennent à une classe dont les substrats ne sont pas métalliques. Deux ATPases appartiennent à une famille spécialisée pour l'efflux du Cu(II) et les quatre autres à une autre grande famille impliquée dans l'efflux des ions Cd(II), Pb(II) et Zn(II). Les analyses transcriptomiques montrent la surexpression des deux premières classes d'ATPases P en présence des métaux lourds. La mutagenèse du gène zntA (mégaplasmide), codant pour l'une des ATPases, provoque une diminution de la viabilité en présence de Zn(II), Cd(II) et dans une moindre mesure de Pb(II), Tl(I) et Bi(III).

Sur pMOL30, la résistance au cuivre implique un groupe de 19 gènes cop codant pour la résistance au cuivre au niveau du périplasme et du cytoplasme, et vraisemblablement pour une forme de stockage du cuivre essentiel. Ces 19 gènes sont surexprimés en présence de cuivre, mais une quinzaine de gènes proches semblent aussi requis pour une expression optimale de la résistance au cuivre.

L'annotation des plasmides a mis en évidence la parenté du plasmide pMOL28 avec le plasmide pHG1 (hydrogénotrophie, fixation du CO2) de C. eutrophus H16 et le plasmide pSym (fixation de l'azote) de C. taiwanensis, et chez pMOL30, la présence de deux îlots génomiques concentrant la plupart des résistances aux métaux lourds. Les puces montrent la surexpression de 83 sur 164 gènes dans pMOL28, et de 143 sur 250 gènes dans pMOL30. Elles montrent aussi que les gènes présents sur les deux plasmides sont davantage surexprimés que ceux localisés sur les deux mégaréplicons. Parmi les gènes surexprimés les plus intéressants du plasmide pMOL30, il faut mentionner des transposases tronquées et des gènes impliqués dans la synthèse des membranes (glycosyltransférases). L'analyse de l'expression des gènes plasmidiens de résistance aux métaux lourds montre la surexpression en présence de plusieurs ions métalliques ajoutés indépendamment et pas seulement par les substrats métalliques de ces opérons, ce qui suggère l'intervention de deux types de régulation dont les gènes correspondants sont aussi localisés sur le chromosome et le mégaplasmide.

Ce travail met en évidence la spécialisation de la bactérie dans la réponse à un grand spectre de concentrations de métaux lourds, jusqu'à la limite majeure de la toxicité observée pour les bactéries mésophiles hétérotrophes. Cette spécialisation correspond bien aux biotopes industriels de divers continents dans lesquels on l'a trouvée.

Doctorat en sciences, Spécialisation biologie moléculaire
info:eu-repo/semantics/nonPublished

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40

Karandikar, Hrushikesh M. "Suitability of cellulose ester derivatives in hot melt extrusion.Thermal, rheological and thermodynamic approaches used in the characterization of cellulose ester derivatives for their suitability in pharmaceutical hot melt extrusion". Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14862.

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Abstract (sommario):

Applications of Hot Melt Extrusion (HME) in pharmaceuticals have become increasingly popular over the years but nonetheless a few obstacles still remain before wide scale implementation. In many instances these improvements are related to both processing and product performance. It is observed that HME process optimisation is majorly focused on the active pharmaceutical ingredient's (API) properties. Characterising polymeric properties for their suitability in HME should be equally studied since the impact of excipients on both product and process performance is just as vital. In this work, two well-established cellulose ester derivatives: Hydroxy Propyl Methyl Cellulose Acetate Succinate (HPMCAS) and Hydroxy Propyl Methyl Cellulose Phthalate (HPMCP) are studied for their HME suitability. Their thermal, thermodynamic, rheological, thermo-chemical and degradation kinetic properties were evaluated with model plasticisers and APIs. It was found the thermal properties of HPMCP are severely compromised whereas HPMCAS is more stable in the processing zone of 150 to 200 °C. Thermodynamic properties revealed that both polymers share an important solubility parameter range (20-30 MPa P1/2P) where the majority of plasticisers and BCS class II APIs lie. Thus, greater miscibility/solubility can be expected. Further, the processability of these two polymers investigated by rheometric measurements showed HPMCAS possesses better flow properties than HPMCP because HPMCP forms a weak network of chain interactions at a molecular level. However, adding plasticisers such as PEG and TEC the flow properties of HPMCP can be tailored. The study also showed that plasticisers have a major influence on thermo-chemical and kinetic properties of polymers. For instance, PEG reduced polymer degradation with reversal in kinetic parameters whereas blends of CA produced detrimental effects and increased polymer degradation with reduction in onset degradation temperatures. Further, both polymers are observed to be chemically reactive with the APIs containing free -OH, -SOR2RN- and -NH2 groups. Finally, these properties prove that suitability of HPMCP is highly debated for HME and demands great care in use while that of HPMCAS is relatively better than HPMCP in many instances.

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41

Karandikar, Hrushikesh M. "Suitability of cellulose ester derivatives in hot melt extrusion : thermal, rheological and thermodynamic approaches used in the characterization of cellulose ester derivatives for their suitability in pharmaceutical hot melt extrusion". Thesis, University of Bradford, 2015. http://hdl.handle.net/10454/14862.

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Abstract (sommario):

Applications of Hot Melt Extrusion (HME) in pharmaceuticals have become increasingly popular over the years but nonetheless a few obstacles still remain before wide scale implementation. In many instances these improvements are related to both processing and product performance. It is observed that HME process optimisation is majorly focused on the active pharmaceutical ingredient's (API) properties. Characterising polymeric properties for their suitability in HME should be equally studied since the impact of excipients on both product and process performance is just as vital. In this work, two well-established cellulose ester derivatives: Hydroxy Propyl Methyl Cellulose Acetate Succinate (HPMCAS) and Hydroxy Propyl Methyl Cellulose Phthalate (HPMCP) are studied for their HME suitability. Their thermal, thermodynamic, rheological, thermo-chemical and degradation kinetic properties were evaluated with model plasticisers and APIs. It was found the thermal properties of HPMCP are severely compromised whereas HPMCAS is more stable in the processing zone of 150 to 200 °C. Thermodynamic properties revealed that both polymers share an important solubility parameter range (20-30 MPa P1/2P) where the majority of plasticisers and BCS class II APIs lie. Thus, greater miscibility/solubility can be expected. Further, the processability of these two polymers investigated by rheometric measurements showed HPMCAS possesses better flow properties than HPMCP because HPMCP forms a weak network of chain interactions at a molecular level. However, adding plasticisers such as PEG and TEC the flow properties of HPMCP can be tailored. The study also showed that plasticisers have a major influence on thermo-chemical and kinetic properties of polymers. For instance, PEG reduced polymer degradation with reversal in kinetic parameters whereas blends of CA produced detrimental effects and increased polymer degradation with reduction in onset degradation temperatures. Further, both polymers are observed to be chemically reactive with the APIs containing free -OH, -SOR2RN- and -NH2 groups. Finally, these properties prove that suitability of HPMCP is highly debated for HME and demands great care in use while that of HPMCAS is relatively better than HPMCP in many instances.

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42

Klečka, Ondřej. "Moderní přístupy k DCF modelu v komparaci s přístupy klasickými". Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-197410.

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Diploma thesis covers the topic about different attitudes to DCF valuation. The first part is an introduction into CAPM theory and a multifactor French-Fama model. This part also indicates different views on financial assets and analyzes an issue of setting discount rates, especially the risk-free rate and equity risk premium. The second part of this paper applies the theory into valuation of Microsoft, GAP and Telefónica O2. There are elaborated forecasts of the financial statements and free cash flows (FCFCE, FCFU), the discount rate composition and analyses of the factors HML and SMB. At the end, there are performed various valuations, which results are discussed together with a development of real market prices.

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43

Sadras, Francisco. "A role for bivalent genes in epithelial to mesenchymal transition". Thesis, 2017. http://hdl.handle.net/2440/109800.

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Epithelial to Mesenchymal Transition (EMT) is an important and complex cellular process in embryonic development, wound healing and tumour progression. EMT is often triggered or facilitated through the action of master EMT transcription factors including ZEB1 and TWIST. It has been proposed that prior to malignant progression a subset of tumour cells undergo an EMT which facilitates the development of key malignant properties. In recent years, a clear link between developmental and cancer associated EMT has triggered an increased interest in the role of developmental EMT genes in a cancer setting. Many key developmental genes have a bivalent or poised promoter signature which changes to active during differentiation; this is believed to elicit a faster response time in comparison to an exclusively repressed promoter. Owing to the relevance of EMT in development and pathologies my thesis aimed to answer the core question of whether bivalent genes are relevant in malignant EMT. To answer this question I undertook four aims: 1. To uncover novel bivalent genes that were activated in an EMT. 2. To characterise the expression and role of ADM2, PLEKHO1 and RASA3 in EMT. 3. To characterise ZEB1 isoform expression during EMT. 4. To identify novel ZEB1 target genes. Aim 1: We utilised a common model of human EMT, whereby human mammary epithelial cells (HMLE) undergo EMT in response to TGFβ to become mesenchymal (mesHMLE). We performed ChIP-seq against histone3 lysine4 tri-methylation (H3K4me3) and histone3 lysine27 tri-methylation (H3K27me3) alongside RNA-seq to identify genes that changed from a bivalent to an active epigenetic signature with concomitant changes to RNA levels. From this data set 429 genes that exhibited this epigenetic change including the well-known EMT factors ZEB1 and TWIST1. From this list four genes that were not previously associated with a bivalent signature were studied in detail. Three of these, ADM2, PLEKHO1 and RASA3, had not previously been associated with EMT but had EMT associated properties, while one, ZEB1 was a well-established master EMT transcription factor. Aim 2: Chromatin immunoprecipitation, ChIP-reChIP was used to confirm the change in epigenetic marks for ADM2, PLEKHO1 and RASA3 promoters alongside a combination of molecular and bioinformatics analyses to determine expression levels in epithelial and mesenchymal cell lines. Cellular migration assays where levels of these genes were manipulated showed that ADM2 and PLEKHO1 have both an individual and a synergistic effect on migration while RASA3 did not affect migration. Aim 3: ZEB1 isoform expression during EMT was analysed and it was determined that there was no significant change in relative expression over this process. Aim 4: ENCODE ZEB1 ChIP-seq was analysed to obtain insights into ZEB1 binding and to identify novel potential targets of importance to EMT. Established ZEB1 target genes such as CDH1 and CRB3 were identified and 26 novel genes with known or potential roles in EMT were chosen for further study. Of these, F11R and INADL were found to be ZEB1 responsive. Direct ZEB1 binding was confirmed through ChIP-qPCR. Interestingly, both of these genes are associated with tight-junctions as is the previously established ZEB1 target CRB3. This strongly implicates ZEB1 in mediating tight-junction regulation. While bivalent genes have not been ignored in the field of EMT they have, so far, been understudied. My work addressed this issue and identified ADM2 and PLEKHO1 as novel EMT associated genes that play an important role in migration. I also established ZEB1, a master regulator of EMT, as a bivalently regulated gene. These contributions help establish bivalently regulated genes as a valuable, underutilised resource for the identification of novel EMT genes.
Thesis (Ph.D.) -- University of Adelaide, School of Biological Sciences, 2017.

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44

Siu, Chau-Shing, e 徐朝興. "The study of GR life prolonging by HMLS spinning mechanism imporvement". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/01759568321000880378.

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碩士
元智大學
機械工程學系
95
The major application of HMLS(high modulus lowly shrinks receives gauze) is to be used as the claming gauze in the tire. Due to its high wearing-resistant characteristic, it will cause the chrome-plating on the surface of GR(godet roll) to be worn and damaged. Thereby form the difficulty in maintance adds up as well as the cost. The general GR surface utilizing ratio is only approximately only 15 – 25% of its total area. But a small partially attritions surface will cause permanent damage and must be replaced, which cost a lot of money. To solve the above problem, the AIR-JET translational mechanism was designed. It consists of a small stepping motor coordinating the large ball bearing for the direct handing and the hollow shaft rotor. When the motor rotates the ground ball screw will drives the AIR-JET which was fixed on slider for, reciprocating horizontal motion. The movement of AIR-JET push is the silk in motion. However, the quality of the silk way be adversely affected. The Taguchi Method was designed to perform experiments in order to obtained operating parameters. Under the optimal operating parameters, the GR surface utilization ratio reaches above 56%. The relative GR life also could be lengthen to 3.5times. Moreover, because of the revising of AIR-JET material, also improve the damage of pottery. It also significantly cut down service requirement and the maintenance expenditure. It reduces the massive stocks of spare parts and the interruption of maintenance work to the production.

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45

Turková, Kateřina. "Sémiotická analýza propagačních materiálů HME v atletice 2015 v Praze". Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-344186.

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The subject of this thesis is the analysis of promotional materials of the sports event - European Indoor Championship in Athletics, which took place from 5 March to 8 March 2015 in Prague. For this purpose, the method of complex semiotic analysis is used. The thesis includes introduction into context. Theoretical background of chosen method is not omitted. In the thesis is explained the application of semiotic analysis to the selected problem. The main and secondary research questions are defined and there are specified the forms of promotion or types of media, on which are the partial semiotic analysis performed, too. This thesis is aimed on revelation differences in promotional materials of the event targeting the general or the professional public. For this reason, in the course of selecting the specific forms of promotion, which are included in the research, was paid attention on the similar characteristic of the pattern for each target group from the viewpoint of media mix. In the sections dedicated to the research are, by the semiotic analysis, analysed chosen promotional materials targeting the general or the professional public. There are interpreted the meanings of symbols and codes used in the promotional materials. Outputs arising from the analysis are evaluated by answering the...

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46

Print, Cristin Gregor. "Investigation of the leucocyte activation antigens CG-1, CD100 and HML-1". 1995. http://hdl.handle.net/2292/3194.

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This thesis describes the investigation of three novel leucocyte activation antigens. The investigation began with the characterisation of the αHML-1 integrin subunit. Immunoprecipitation analysis and Western blotting indicated that αHML-1 associates with the β7 integrin subunit to form a typical integrin heterodimer. αHML-1 appears to be post-translationally cleaved into heavy and light chains which remain linked by disulphide bonds. With the aim of isolating the αHML-1 protein, a 45kDa disulphide-linked polypeptide was isolated from leucocytes by two-dimensional non-reducing / reducing gel electrophoresis, and used to raise a polyclonal antiserum. This polyclonal antiserum detected a protein encoded by a cDNA in a λgt11 leucocyte expression library. This cDNA was designated CG-1. It became apparent that CG-1 did not encode the αHML-1 protein, but rather encoded a novel protein which is abundantly expressed in activated leucocytes and reproductive tissues, and weakly expressed in all other tissues examined. The CG-1 gene may be one member of a larger gene family, as two different chicken relatives of CG-1 have been isolated elsewhere. The deduced CG-1 amino acid sequence contains potential transmembrane domains and a potential nuclear localisation signal motif. On the basis of its primary structure the CG-1 protein is expected to form an α helical coiled-coil dimer. A polyclonal antisera raised against a CG-1 - β-galactosidase fusion protein detected a 300kDa protein on the surface of activated human leucocytes. The apparent molecular weight of this protein is halved following the reduction of disulphide bonds, supporting the contention that CG-1 is a disulphide-linked cell-surface dimer. This protein appears to be associated with tyrosine kinase activity in an in vitro kinase assay. While participating in the Fifth International Conference on Leucocyte Differentiation Antigens we noted that the protein detected by the anti-CG-1 antisera was remarkably similar to a novel leucocyte protein designated CD100. CD100 is a T lymphocyte co-stimulatory antigen capable of signalling in concert with the T lymphocyte antigen receptor to produce T lymphocyte proliferation. Like the protein detected by the anti-CG-1 antisera, CD 100 was associated with tyrosine kinase activity in an in vitro kinase assay, and appeared to be a 300kDa disulphide-linked cell-surface dimer. Anti-CD100 antibodies were able to remove the protein detected by the anti-CG-1 antisera from leucocyte lysates in immunodepletion experiments. This suggests that CG-1 and CD100 are immunologically related, or that CD100 and the protein detected by the anti-CG-1 antisera are physically associated. Current research is directed toward determining the relationship between CG-1 and CD100, and investigating the signalling and costimulatory potential of these molecules. The three leucocyte activation antigens investigated in this thesis all appear to mediate leucocyte transmembrane signalling. All three molecules potentially form the basis of therapeutic approaches for immunoregulation of inflammatory and neoplastic disease.

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47

Sedlacek, Bernhard [Verfasser]. "Die Befeuchtungsleistung hydrophober Heat and Moisture Exchanger (HME) unter klinischen Bedingungen / von Bernhard Sedlacek". 2006. http://d-nb.info/980901340/34.

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48

Weber, Jan Maria [Verfasser]. "Regulation of replication initiation and HML silencing in Saccharomyces cerevisiae / vorgelegt von Jan Weber". 2010. http://d-nb.info/1008951013/34.

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49

Keiner, Nadine. "Aktivität endogener Retroviren in Tumorgeweben von Primaten". Doctoral thesis, 2009. http://hdl.handle.net/11858/00-1735-0000-0006-AD71-C.

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50

Tai, Yu-ting, e 戴玉婷. "The Development and Construction of the Holistic Meaning of Life Scale (HMLS) for junior high school students of Taiwan". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/61538191574012113896.

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碩士
南華大學
生死學研究所
98
The scale is based on the viewpoints and theories related to the life meaning of Rogers, Erikson, Viktor, Frankl, May and Yalom. The mtain purpose of the research is to set up a“Holistic Meaning of life Scale(HMLS) for junior high school students of Taiwan”,including seven dimensions --life goal, life value, life freedom, self-concept, religion support, death acceptance, ascension and 56 items. 　　　The scale is implemented by stratified cluster sampling. The 1102 testees are drawn from northern part, central part, southern part and eastern part of Taiwan. 　　　The whole scale internal consistency reliability Cronbach’s α coefficient is 0.801 and the test-retest reliability is 0.966 which is an evidence of stability and consistency. Furthermore, through Canonical Correlation Analysis, it reveals that the similarity 0.69 between the scale and Purpose of life scale set up by Song Qiu-Rong in 1992. In terms of the evaluation of the mode of goodness of fit, the result shows that only the life freedom part needed further adjusting, whereas the rest six dimensions were correspond to the condition. Therefore, this scale reaches the medium level of the mode of goodness of fit. 　　　Based on the above-mentioned analysis, the Holistic Meaning of life Scale (HMLS) is a suitable scale for junior high school students of Taiwan with stable reliability and validity.

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