Tesi sul tema "Identification de la charge utile"
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Brizard, Denis. "Contrôle des vibrations de charge utile sur lanceur spatial". Thesis, Ecully, Ecole centrale de Lyon, 2011. http://www.theses.fr/2011ECDL0041/document.
Testo completoSpace launchers undergo a certain amount of complex excitations during their lifecycle. These excitations are transmitted to the payload in a structure-born or air-born way. To improve the dynamic behaviour and thus ensure the protection of the payload, secondary systems must be added to the launcher – indeed, the architecture of the launcher is fixed at the beginning of the project. The essential part of this thesis work is dedicated to the optimal fitting of a system capable of reducing the vibration response of the payload, using appropriate models. Therefore a double modal synthesis method is implemented, allowing to calculate the vibrational response of the structure with reduced bases and offering improved performances over conventional methods. The addition of a local damping device requires the consideration of one or more structural modifications in the model, a dedicated method is thus developped along with a specific continuation algorithm. A friction damper is retained, a prototype is designed and built. It is first characterized alone ; the identified behaviour is that of a spring in series with a dry friction element, a simple Coulomb friction law enables to reproduce the experimental curves. A scale model of the launcher’s last stage is designed and built. The friction device is then mounted inside the scale model and leads to a significant reduction of the payload vibration levels
Tout, Bilal. "Identification of human-robot systems in physical interaction : application to muscle activity detection". Electronic Thesis or Diss., Valenciennes, Université Polytechnique Hauts-de-France, 2024. https://ged.uphf.fr/nuxeo/site/esupversions/36d9eab3-c170-4e40-abb6-e6b4e27aeee2.
Testo completoOver the last years, physical human-robot interaction has become an important research subject, for example for rehabilitation applications. This PhD aims at improving these interactions, as part of model-based controllers development, using parametric identification approaches to identify models of the systems in interaction. The goal is to develop identification methods taking into account the variability and complexity of the human body, and only using the sensor of the robotic system to avoid adding external sensors. The different approaches presented in this thesis are tested experimentally on a one degree of freedom (1-DOF) system allowing the interaction with a person’s hand.After a 1st chapter presenting the state-of-the-art, the 2nd chapter tackles the identification methods developed in robotics as well as the issue of data filtering, analyzed both in simulation and experimentally. The question of the low-pass filter tuning is addressed, and in particular the choice of the cut-off frequency which remains delicate for a nonlinear system. To overcome these difficulties, a filtering technique using an extended Kalman filter (EKF) is developed from the robot dynamic model. The proposed EKF formulation allows a filter tuning depending on the known properties of the sensor and on the confidence on the initial parameters estimations. This method is compared in simulation and experimentally to different existing methods by analyzing its sensitivity to initialization and filter tuning. Results show that the proposed method is promising if the EKF is correctly tuned.The 3rd chapter concerns the continuous identification of the parameters of the model of a passive system interacting with a robotic system, by combining payload identification methods with online identification algorithms, without external sensors. These methods are validated in simulation and experimentally with the 1-DOF system whose handle is attached to elastic rubber bands to emulate a passive human joint. The analysis of the effects of the online methods tuning highlights a necessary trade-off between the convergence speed and the accuracy of the parameters estimates. Finally, the comparison of the payload identification methods shows that methods identifying separately the robotic system and the passive human parameters give better accuracy and a lower computation complexity.The 4th chapter deals with the identification during the human-robot interaction. A quadratic stiffness model is proposed to better fit the passive human joint behavior than a linear stiffness model. Then, this model is used with an iterative identification method based on outlier rejection technique, to detect the human user muscle activity without external sensors. This method is compared experimentally to a non-iterative method that uses electromyography (EMG), by adapting the 1-DOF system to interact with the wrist and to allow the detection of the flexor and extensor muscle activity of two human users. The proposed iterative identification method not using EMG signals achieves results close to those obtained with the non-iterative method using EMG signals when a model that correctly represents the passive human joint behavior is selected. The muscle activity detection results obtained with both methods show a satisfactory level of similarity compared to those obtained directly from EMG signals
Camino, Jean-Thomas. "Co-optimisation charge utile satellite et système télécom". Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30401.
Testo completoThe continuous growth in telecommunication needs in our society translates into a series of technical challenges for the systems that provide such services, whether it is television broadcasting, telephone, or data exchange. The telecommunication satellites are particularly concerned by this need for innovation, both on the embarked technologies but also on the way the resulting resources are exploited for the end users. On the latter point, for a telecommunication mission defined precisely in terms of service zone, type, quantity and quality of service, one has to be able to size as adequately as possible the telecommunication satellite payload, under the several constraints it is subject to: mass, volume, cost, and power consumption of the embarked hardware. This thesis develops an algorithmic approach for a such a sizing in the particular case of the telecommunication systems that are said to be "multi-beam". A global optimization process of these satellite system is proposed. It relies on a decomposition into a set of mathematical problems whose respective complexities, reduced with respect to the original problem, allow to reasonably aim for efficient algorithmic solutions. This work allowed to identify two key problems in this satellite payload sizing, addressed through an operations research angle: the beam layout optimization and the frequency plan optimization. This first beam layout problem under payload constraints has been an occasion to propose novel ways to handle Euclidean norm constraints on continuous variables for non-convex non-linear mixed programs. These techniques have been then successfully applied in for the generation of solutions to this first problem that fully exploits the mixed integer linear programming formalism. Then, a novel exploitation of some of the properties of the k-means clustering has been proposed as it allows to simplify these mathematical models and therefore accelerate the beam layout optimization. These mathematical programming algorithms have been then compared to a greedy heuristic developed during this thesis work. The second central sizing problem that has been identified is the frequency plan definition. It consists in a resource allocation of on-board satellite resources to the several beams that have been defined in the preceding beam layout optimization problem. With an objective of minimizing the number of a certain type of hardware to be embarked on the payload, the satisfaction of the telecommunication mission defined by an individual demand of all the end users on the ground is aimed. This complex problem itself lead to a decomposition into two sub-problems of frequency and on-board payload hardware allocation, that are treated with constraints programming and integer linear programming, exploiting theoretical results that are useful both at the problem modeling and problem solving levels
Rebeyrol, Emilie. "Optimisation des signaux et de la charge utile Galileo". Phd thesis, Télécom ParisTech, 2007. http://pastel.archives-ouvertes.fr/pastel-00004315.
Testo completoBessaih, Fawzi Cheik. "Optimisation et validation de la charge utile d'un satellite de télécommunication". Thesis, Avignon, 2013. http://www.theses.fr/2013AVIG0196/document.
Testo completoNc
Cances, Jean-Pierre. "Adaptativité d'une charge utile de télécommunication multifaisceaux par reconfiguration de couverture /". Paris : École nationale supérieure des télécommunications, 1994. http://catalogue.bnf.fr/ark:/12148/cb35737325r.
Testo completoJean, Pierrick. "Isolation vibratoire par contrôle semi-actif d'amortisseurs magnéto-rhéologiques pour l'interface lanceur/charge utile". Phd thesis, Conservatoire national des arts et metiers - CNAM, 2006. http://tel.archives-ouvertes.fr/tel-00352710.
Testo completoPhiloreau, Sandrine. "Contribution du calcul formel a l'ingenierie optique elaboration d'une methode de gestion des performances d'une charge utile optique". Nice, 1997. http://www.theses.fr/1997NICE5065.
Testo completoBariant, Delphine. "Méthodologie d'aide à la conception électromagnétique de dispositifs microondes : Application au filtrage et au multiplexage de charge utile de satellite". Limoges, 2002. http://www.theses.fr/2002LIMO0050.
Testo completoThe filters and the output multiplexers of payload of satellite are in the beginning of improvement of performance, time of design and time of realization. The research tasks presented here are on the development of methods of assistance to the electromagnetic design of these devices. The methods of assistance to the electromagnetic design of the filters, used and developed here, make it possible, on the one hand, to obtain final dimensions of the filters for an experimental realization (machining only one set of cavities and irises). They also make it possible to characterize quickly and efficiently the filters in an electromagnetic way. These methods were validated by the design of two filters in dual-mode cavities functionning in Ku-band and in Ka-band and were validated with experimental results. The electromagnetic characterization of the filters permits to consider the analysis of multiplexers. It was at the origin of the development of methods of assistance to the electromagnetic design of multiplexers. The methods presented contribute to the conception of multiplexers by modelling the dephasing introduced the excitation systems. The second axis presented permits to compensate for the influence of spurious modes disturbing the response of the OMUX. Then, these methods make it possible to consider a fast and rigorous electromagnetic characterization of multiplexers and thus, to answer the problems involved in the growing number of channels which constitute it
Pazart, Lionel-Henri. "Recherche en méthodologie d'évaluation des pratiques médicales : contribution à l'élaboration d'une méthode directement utile à la prise en charge des patients analysés". Lille 2, 2005. http://www.theses.fr/2005LIL2S018.
Testo completoThis thesis is a research in methodology of evaluation of the professional practices. The original approach consists in proposing a method making it possible to achieve a double goal: on the one hand to immediately use the results for the benefit of the patients included in the evaluation and on the other hand to answer the obligation of evaluation of the professional practices such as she is currently recommended by the High Authority of Health (HAS). Continuing a work initiated on the methodology of the investigations of practices applied to the evaluation of the practices of care, and within the framework of the Grouping of Public Interest "ReQua" of Franche-comté, we checked with studies on various topics (psychiatry, nutrition, geriatrics) that an evaluation of the occupational practices pursuing the double goal describes higher, feasible, acceptable by the professionals and was recognized by the HAS
Tany, Michel. "La prise en charge des toxicomanes entre la communauté thérapeutique et l’aventure de l’écoute psychanalytique". Thesis, Paris 10, 2014. http://www.theses.fr/2014PA100073.
Testo completoThis research intend to examine the multiple interests to integrate the psychoanalytic approach in a specific context of care for drug addicts : the therapeutic community (TC). Based on my clinical experience in Lebanon with drug abusers that I have met in CT, I expose the pitfalls of this form of care founded exclusively on the behavioral approach. I also describe the drug addiction as “clinic of the similar”. This clinic is based on identification processes that rely upon a tripod : the social opinions regarding the drug dependency phenomenon, some scientific discourse about addiction, but especially on the dependent subjects own psychological functioning. The central hub of my proposition is located in the fact that when they meet a caregiver who has not necessarily been drug user himself, most addicted patients argue that he is not similar to them, so he would never understand their pain. This situation can be considered as a form of resistance, but it allows me to conceive the function of the drug in terms of identificatory issues. I use psychoanalytic theory to deconstruct a pseudo-knowledge built around the complex phenomenon of drug addiction. This knowledge tends to freeze addicts in concepts that lead to controversial practices (including CT). I try to refocus the question of the substance abuse on the addicted patient himself, with his identification problems and fantasies that incite him to join a community of people having behaviors well codified
Atienza, García María Terersa. "Identification and control of diffusive systems applied to charge trapping and thermal space sensors". Doctoral thesis, Universitat Politècnica de Catalunya, 2018. http://hdl.handle.net/10803/462165.
Testo completoEl trabajo que subyace a esta Tesis, ha contribuido principalmente al estudio y la caracterización de los sistemas difusivos. El trabajo de investigación se ha centrado en el análisis de dos tipos de sistemas. Por un lado, la dinámica de los anemómetros térmicos ha sido estudiada en profundidad. Estos sensores detectan la velocidad del viento a través de la medida de la potencia disipada en un elemento caliente debido a la convección forzada. Durante el trabajo de esta Tesis, se ha analizado y modelado la dinámica térmica de diferentes sensores . Por otro lado, se han tratado también los sistemas microelectromecánicos (MEMS). Se ha estudiado la dinámica de la carga atrapada en la capa dieléctrica de estos sistemas. Este fenómeno lento e indeseado está asociado a fenómenos de difusión. En esta Tesis se presenta un método de caracterización basado en la técnica de Representación Difusa (DR), para sistemas difusivos lineales y no lineales que varían en el tiempo. Esta técnica permite describir un sistema con un modelo de variables de estado de orden arbitrario en el dominio frecuencial. Los cambios en la dinámica de un sistema a lo largo del tiempo pueden ser debidos a la propia actuación sobre el dispositivo o como resultado de una perturbación externa. En el caso del sensor de viento, la variación de tiempo del modelo proviene de la propia variación del viento, la cual es una perturbación externa, mientras que en el caso de los dispositivos MEMS, los cambios en la tensión de actuación generan variaciones en el tiempo en el modelo. Los modelos de variables de estado obtenidos a partir de la caracterización con Representación Difusiva tienen la capacidad de reproducir y predecir el comportamiento de dichos dispositivos ante excitaciones arbitrarias. En concreto, en el caso de los sensores de viento, la dinámica térmica de estos sensores, operando a temperatura constante, se ha predicho para diferentes velocidades de viento, usando la teoría de los Sliding Mode Controllers (Controladores de Modo Deslizante). Tal y como se ha observado, estos controladores ayudan también a comprender cómo la respuesta temporal de un sistema, en lazo cerrado, puede acelerarse más allá del límite natural impuesto por su propio circuito térmico si el filtro térmico asociado a la estructura del sensor tiene solo una constante de tiempo significativa. La corroboración experimental del análisis térmico se presenta con varios prototipos de sensores de viento para la atmósfera de Marte. Por un lado, se han obtenido los modelos de la dinámica térmica variable en el tiempo de dos prototipos diferentes de un sensor de viento 3D esférico, desarrollado por el grupo de Micro y Nano Tecnologías de la UPC. Por otro lado, se ha caracterizado el prototipo de modelo de ingeniería del sensor de viento del instrumento REMS (Rover Environmental Monitoring Station) que está actualmente abordo del rover Curiosity en Marte. Para la caracterización de la dinámica de la carga atrapada en la capa dieléctrica de un dispositivo MEMS, la validación experimental se ha obtenido a través de medidas cuasi-diferenciales de la capacidad de un dispositivo MEMS con estructura de dos placas paralelas.
Vivos, Jonathan. "Méthode de conception de déphaseurs à métamatériaux par l'utilisation de lignes composites équilibrée et non équilibrée". Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30327.
Testo completoDifferential phase shifters (DPS) are used in in parallel structures such as Butler matrices, to avoid losses on signal recombination to avoid losses on signal recombination. The DPS are generally composed of two transmission lines out of phase with each other. The phase shift control in these devices line length adjustment, or by integrating elements such as coupled lines or stubs. However, these solutions do not meet the many specifications of the phase shifter in an industrial context. Metamaterials, which are known as structures composed of several small elements, with unique properties, could enable phase shift control with more degrees of freedom. To this end, metamaterials such as composite lines have already been investigated. However they exploit a particular case of metamaterial, the balanced line, to design phase shifters. This thesis objective is to design metamaterial phase shifters by exploiting as much as possible their degrees of freedom, namely without limiting the phase shift design to balanced lines. For this purpose, we have implemented a dedicated design method to obtain from phase shifter specifications solutions with adequate performances for integration on very constrained industrial systems. This method has been illustrated and validated through an application to a case of 180° phase shifter with a 20% bandwidth in C band [4.95GHz -6.05GHz]
Zayane, Chadia. "Identification d'un modèle de comportement thermique de bâtiment à partir de sa courbe de charge". Phd thesis, Centre de géosciences (Fontainebleau, Seine et Marne), 2011. https://pastel.hal.science/pastel-00590810.
Testo completoIn a context of permanent concern of energy saving, the importance of developing strategies to minimize the energy consumption of a building is not to be any more demonstrated. Whether these strategies consist in recommending building insulation, suggesting the modification of the management of heating/air conditioning systems or advising the change of certain occupants' habits, a preliminary step of characterizing the thermal behavior of the building turns out inevitable. Contrary to the previous studies, the approach developed here does not require instrumentation of the building. Also, we consider buildings in normal occupation, that is in the presence of heating regulator, which is an additional unknown of the problem. So, we identify a global system of the building together with its heating system from: meteorological data of the closest Meteo France station; reference indoor temperature reconstructed by sector-based knowledge; heating consumption collected either from Building Management Systems or from smart meters; other heat supply (like lighting or presence of persons) estimated by sector-based and thermal knowledge. The identification is made at first by estimation of the parameters (7) defining the global model, by minimizing one step prediction error. Then we adopted an approach of bayesian inversion which provides a simulation of the posterior distributions of parameters and building indoor temperature. The analysis of the stochastic simulations aims at studying the contribution of additional knowledge of the problem (typical values of the parameters) and at showing the limits of the modeling hypotheses in the case of certain real data sets
Zayane, Chadia. "Identification d'un modèle de comportement thermique de bâtiment à partir de sa courbe de charge". Phd thesis, École Nationale Supérieure des Mines de Paris, 2011. http://pastel.archives-ouvertes.fr/pastel-00590810.
Testo completoContrairement aux études existantes, la démarche menée ici ne nécessite pas d'instrumentation du bâtiment. De même, nous considérons des bâtiments en occupation normale, en présence de régulateur de chauffage : inconnue supplémentaire du problème. Ainsi, nous identifions un système global du bâtiment muni de son régulateur à partir de :
données de la station Météo France la plus proche ; la température de consigne reconstruite par connaissance sectorielle ; la consommation de chauffage obtenue par système de Gestion Technique du Bâtiment ou par compteur intelligent ; autres apports calorifiques (éclairage, présence de personnes...) estimés par connaissance sectorielle et thermique. L'identification est d'abord faite par estimation des paramètres (7) définissant le modèle global, en minimisant l'erreur de prédiction à un pas. Ensuite nous avons adopté une démarche d'inversion bayésienne, dont le résultat est une simulation des distributions a posteriori des paramètres et de la température intérieure du bâtiment.
L'analyse des simulations stochastiques obtenues vise à étudier l'apport de connaissances supplémentaires du problème (valeurs typiques des paramètres) et à démontrer les limites des hypothèses de modélisation dans certains cas.
Marshall, Blake Ryan. "A methodology for designing staggered pattern charge collectors". Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/43612.
Testo completoRomero, Ugalde Héctor Manuel. "Identification de systèmes utilisant les réseaux de neurones : un compromis entre précision, complexité et charge de calculs". Thesis, Paris, ENSAM, 2013. http://www.theses.fr/2013ENAM0001/document.
Testo completoThis report concerns the research topic of black box nonlinear system identification. In effect, among all the various and numerous techniques developed in this field of research these last decades, it seems still interesting to investigate the neural network approach in complex system model estimation. Even if accurate models have been derived, the main drawbacks of these techniques remain the large number of parameters required and, as a consequence, the important computational cost necessary to obtain the convenient level of the model accuracy desired. Hence, motivated to address these drawbacks, we achieved a complete and efficient system identification methodology providing balanced accuracy, complexity and cost models by proposing, firstly, new neural network structures particularly adapted to a very wide use in practical nonlinear system modeling, secondly, a simple and efficient model reduction technique, and, thirdly, a computational cost reduction procedure. It is important to notice that these last two reduction techniques can be applied to a very large range of neural network architectures under two simple specific assumptions which are not at all restricting. Finally, the last important contribution of this work is to have shown that this estimation phase can be achieved in a robust framework if the quality of identification data compels it. In order to validate the proposed system identification procedure, application examples driven in simulation and on a real process, satisfactorily validated all the contributions of this thesis, confirming all the interest of this work
Romero, ugalde Héctor manuel. "Identification de systèmes utilisant les réseaux de neurones : un compromis entre précision, complexité et charge de calculs". Phd thesis, Ecole nationale supérieure d'arts et métiers - ENSAM, 2013. http://pastel.archives-ouvertes.fr/pastel-00869428.
Testo completoTajany, Mostafa. "Égalisation adaptative de multitrajets dans des liaisons de télémesure à haut débit". Nantes, 1996. http://www.theses.fr/1996NANT2002.
Testo completoDumont, Sarah. "Caractéristiques cliniques, moléculaires et prise en charge des Rhabdomyosarcomes de l'adulte et identification d'une polythérapie ciblée in vitro". Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10311/document.
Testo completoRhabdomyosarcoma is a rare entity adult patient with unfavourable outcome. This work describes the clinical and molecular specificities of adolescent and adult type of rhabdomyosarcoma and investigates the optimal integration of targetd therapy combinations on small cell sarcoma cell lines in vitro. We retrospectively analyzed 239 patients, 10 years of age and greater, diagonsed withrhabdomyosarcoma at MD Anderson Cancer Center from 1957 trough 2003 and their PAX-FOXO1 fusion gene status by fluorescence in situ hybridization on tissues microarray. Three samll cell sarcoma cell lines were exposed to targetd agent combinations. PAtient with metastatic rhabdomyosarcoma were found to have a 18 % survival rate at 5 years from diagnosis with an 12 %survival past 15 years. This outcome was even poorer for patients over 50 of age, even with localized disease. Younger patients were more likely to receive multidisciplinary therapy than their older counterparts. The presence of PAX-FOXO1 tranlocation was significantly associated with a higher frequency of metastatic disease. The four agents with the exception of abacavir synergized two by two with each other in vitro but the triple combinations did not perform beter than the bitherapies. The dual therapies vorinostat 5HDAC inhibitor) plus 17-DMAG (Hsp90 inhibitor) added with doxorubicin achvied better results than dual or triple therapies. Adult patient with rhabdomyosarcoma present similar molecular and clinical characteristics compared pediatric patients but outcome decrease with age partly du to a less multimodal management. Moreover targeted combinations should be integrated to chemotherapy backbone
Hamon, Pauline. "Modélisation et identification dynamiques des robots avec un modèle de frottement sec fonction de la charge et de la vitesse". Nantes, 2011. http://archive.bu.univ-nantes.fr/pollux/show.action?id=f707db5d-d950-4065-a4f1-96b0543b2c18.
Testo completoThis work is the result of collaboration between CEA and IRCCyN in the area of teleoperation and cobotics, where robots work at low velocity and with high external forces variations. In this range of use, the joint dry friction force becomes significant compared with the inertial forces. The dynamic model with the usual constant dry sliding friction force model is no longer accurate enough to predict the joint forces and therefore to predict the interaction forces between the robot and its material or human environment. This thesis proposes an original dry friction model, which depends on the joint load and velocity. This model is merged into the multi-joint inverse dynamic model, which is identified with linear least squares techniques. An experimental study of several one-joint robots leads to propose a new dry friction model that combines the load-dependence of the Coulomb model and the velocity-dependence of the Stribeck model, and that is suitable for the 4 quadrants in the (velocity, load) frame. This model is incorporated into the multi-joint inverse dynamic model that remains linear in relation to the new dynamic parameters. The usual robotics identification method, based on linear least squares techniques, is divided in two steps for the new model: at first, a joint-by-joint procedure allows to identify some friction parameters, and then a multi-joint identification is carried out to estimate the other friction and inertial parameters. An experimental validation on seven one-joint cases and on a multi-joint case (4 joints of the Stäubli TX40 robot) proves the relevance of this original approach for robots working with high load variations and/or at low velocity
Delmas, Hugues. "Expressions faciales et mensonges factuels : évaluation des croyances et identification des expressions produites lors d’un mensonge à forte charge cognitive". Thesis, Paris 8, 2018. http://www.theses.fr/2018PA080036.
Testo completoTwo factors increase the lie detection performance: (a) identify and decrease false beliefsand (b) increase behavioral differences between liars and truth-tellers. These factors were studiedin relation to facial expressions of deception in this doctoral dissertation.The present work questioned (a) The most important beliefs about facial expressions ofdeception throught the use of a photographic questionnaire (b) The influence of professionalexperience, stakes of lie (serious or trivial) and the lying behavior evaluated (his own or that ofothers) (c) The relevance of facial expressions’ intensity to detect lies in an reverse orderinstruction which was used to magnify behavioral differences (cognitive load approach).Our results highlighted many new beliefs. Seven of them were very shared by people andconsistent with the stereotypical view of the liar. Beliefs were little infuenced by professionalexperience, the stakes of lie and the evaluated behavior. The reverse order instruction amplifieddifferences between liars and truth-tellers; and the intensity of facial movements was a relevantmeasure for detecting deception. Application of our research is discussed
Maciel, Soares Julia. "La notion d'autre "suffisamment pareil" dans la rencontre intersubjective : implications dans la prise en charge de l'autisme". Paris 13, 2012. http://www.theses.fr/2012PA131008.
Testo completoAutism questions the several theoretical formulations that attempt to understand the processes involved in psychic development. What the French 3i method suggests as a treatment of autism allows to question further the psychoanalytic theory, with which a link can be proposed. Since the goal of the 3i therapeutic sessions is to establish interactions, a few orientations are given to adults to create moments of contact, for instance to imitate the child and to not to say "no" during the sessions. We propose to investigate the reasons of these assumptions in connection with what happens during the first period of the psychic development. When reworking the first intersubjective encounters, we observed that imitation and attunement that characterize them indicate that these encounters are marked by resemblance more then by difference. Our proposition is to consider the other of these first intersubjective encounters as a “similar enough other”. Being autism a clinic of the archaic period of psychic development, we think that this type of encounter where the difference does not stand out points to a type of relation with the other in a way that autistic children could accept. Based upon an autistic child that was seen for 20 months under the 3i method, we discuss the clinical implications of our proposition. The discussion, based upon the principles of the intervention proposed by this method, indicate that based on encounters of this nature, the "similar enough" can become gradually less similar. The progress of the child that was seen under the umbrella of the 3i method allows to infer some therapeutic benefits of this type of encounter, initiated by an other who presents himself at first as similar enough to the child
O autismo questiona as diversas formulações teóricas que se esforçam em compreender os processos implicados no desenvolvimento psíquico. O que propõe o método francês dos 3i como tratamento do autismo permite avançar as questões que o autismo coloca especialmente à teoria psicanalítica, com a qual uma articulação pode ser elaborada. Sendo a interação o objetivo das sessões 3i, algumas orientações são dadas aos adultos que intervém no sentido de criar momentos de encontro, dentre elas a de imitar a criança e a de não dizer “não” nas sessões. Propomos investigar os fundamentos dessas premissas a partir de uma articulação com o que se passa no primeiro tempo da constituição psíquica. Ao retrabalhar os primeiros encontros intersubjetivos, observamos que a imitação e a sintonia que lhes são característicos indicam que esses encontros são marcados mais pela semelhança e menos pela diferença. Nossa proposição é a considerar o outro desses primeiros encontros intersubjetivos como um outro “suficientemente similar” ao sujeito. Sendo o autismo uma clínica do tempo arcaico do psiquismo, pensamos que esse tipo de encontro onde a diferença não figura em primeiro plano remete a um tipo de relação com o outro que as crianças autistas são capazes de suportar. A partir do caso de uma criança autista atendida por 20 meses dentro dos moldes do método dos 3i, discutimos as implicações clínicas da nossa proposição. A discussão, que tem por eixos os princípios de intervenção propostos pelo método dos 3i, indica que a partir de encontros dessa natureza, possíveis à criança autista, o “suficientemente similar” pode tornar-se cada vez menos similar. A evolução do caso da criança atendida nos moldes do método 3i permite inferior alguns efeitos terapêuticos desse tipo de encontro, provocado por um outro que se apresenta inicialmente como suficientemente similar com a criança
Chouihed, Tahar. "Identification des profils congestifs de l'insuffisance cardiaque aiguë pour guider les stratégies diagnostiques et thérapeutiques de prise en charge en urgence". Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0065/document.
Testo completoAcute dyspnea due to pulmonary congestion in acute heart failure (AHF) is a common reason for admission to the ER. Currently, AHF is twice as common and associated with a twofold higher risk of death (8%) than acute coronary syndromes (ACS). Pre-hospital and emergency care has become the cornerstone of care of these patients. In recent years, new paradigms have emerged surrounding AHF management, highlighting the complexity of this disease. Hence the use of the term acute heart failure syndrome (AHFS), a terminology underscoring the plurality of clinical situations and the diversity of congestive profiles. However, the assessment of congestion distribution during an AHFS is currently predominantly based on clinical arguments in spite of limited data. Alternatively, lung ultrasound (LUS) and estimation of plasma volume (ePVS, based on hemoglobin and hematocrit) could allow for a better assessment of congestive profiles. Several studies report that the rapid and accurate etiological diagnosis of acute dyspnea is associated with prognosis. Despite the availability of diagnostic tools including clinical exam, biomarkers and radiology, there is still considerable uncertainty regarding etiological diagnosis in the emergency department (ED) setting, hence rendering it difficult in reducing the « Time to therapy » advocated by the recommendations of the European Cardiology Society 2016 for AHF. The objectives of the present work were to identify distinct congestion profiles of AHF, to clarify the diagnostic and prognostic value of these profiles in the context of acute dyspnea, and to determine whether the therapeutic effect of initial emergency management modalities is dependent on these congestive profiles. In the course of our work, we were able to demonstrate in the DeFSSICA cohort that the tools allowing a better assessment of the patient's congestive profile (particularly LUS and ePVS) are rarely used in ED. In a second study, we showed in the PARADISE cohort (NCT02800122) - designed as part of this PhD research project - that impaired renal function, hyponatremia and dysglycemia are significantly associated with prognosis in patients with acute dyspnea. In a third study, we showed that the ePVS is an effective AHF diagnostic tool and that a higher congestion level assessed by ePVS is associated with higher in-hospital mortality of patients admitted for acute dyspnea. Our work also enabled us to design and initiate the PURPLE (Pathway and Urgent caRe of dyspneic Patients at the emergency department in LorrainE district - NCT03194243) study, which collects clinical and paraclinical data of patients admitted for acute dyspnea on a prospective basis. Lastly, this PhD research project enabled designing and obtain funding for the EMERALD-US project (Evaluation of the feasibility of implementing and performance of an Emergency Echography algorithm for the diagnosis of Acute Dyspnea-UltraSound) which aims to validate an original algorithm specific to emergency situations using lung, cardiac and vascular ultrasound for the etiological diagnosis of acute dyspnea
Hu, Yiran. "Identification and State Estimation for Linear Parameter Varying Systems with Application to Battery Management System Design". The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281368350.
Testo completoThouras, Jordan. "Amélioration des performances électriques d’un module de mélange optoélectronique privilégiant des dispositifs à semi-conducteurs : Applications dans les charges utiles de satellites". Thesis, Limoges, 2016. http://www.theses.fr/2016LIMO0127/document.
Testo completoNowadays, Satellite telecommunications are becoming very popular and the number of subscribers worldwide is always growing. Wherever the optical fiber cannot be deployed, they are a reliable way to provide very high data rates to the users, whose activities are becoming more and more bandwidth-hungry (HD video, video conferencing, downloading, cloud computing, online games ...). They also guarantee very large coverage areas. In order to follow the market needs satellite payload designers have to increase the number of on-board equipment, which affects the volume and mass of the systems and therefore the launching cost. One of the solutions to solve the problem consists in using optical technologies. It has been demonstrated by Thales Alenia Space that In the case of a reference signal distribution system for 64 devices, a weight reduction of about 70% could be obtained. In this context we have developed 7 RF frequencydown-converters based on photonic semiconductor components. The down-converters are key components of satellite payloads, as their aim is to isolate uplink transmissions (ground to satellite) and downlink (satellite to ground) to avoid interference. Performance of the 7 architectures, incorporating electro-absorption modulators (EAM) and semiconductor optical amplifiers (SOA) were evaluated through various simulations and by calculating the conversion gain, noise figure, RF/IF and LO/IF isolations, the C/I3 ratio and the coordinates of the third order intercept point. We obtained interesting results, first data for futur works,and showed that these converters are compatible with many frequency plans in Ku/Ku, ku+/Ku, and Ka/Ka bands. Manipulations were also led and validated the theoretical models used in simulations
Jablonski, Christine. "Santé de la femme et pathologie chronique : identification de comorbidités et facteurs de risque ; impact d'une prise en charge gynécologique spécifique : exemple de la mucoviscidose". Thesis, Lyon, 2020. https://n2t.net/ark:/47881/m6v987dw.
Testo completoLife expectancy of patients with cystic fibrosis (CF) improved through different types of therapeutic and organizational interventions. As a result, new issues are emerging, such as gynecological management and sexual health in adult women with CF. The main objective of this work was to evaluate the gynecological management of women with CF, to describe their gynecological comorbidities, and to propose means to improve their management and prevention.A first descriptive study conducted in Lyon CF centre, found an insufficient gynecological management (proportion and frequency of women followed, contraceptive coverage and cervical screening). The impact of a gynecological consultation offer in the CF centre was then assessed two years after its implementation, with a significant improvement in gynecological management (according to the same three indicators). Gynecological comorbidities specific to CF were described, including a high frequency of cervical disease due to papillomavirus (HPV) infection (in transplanted, and non-transplanted women). A prospective study was then conducted to better understand the pathophysiological link between CF and cervical disease, exploring the natural history of HPV infection in this specific population. The epidemiological link between CF and cervical disease is also being evaluated through a national-wide study based on french national health insurance data and the French CF Registry. Finally, we have described an insufficient HPV vaccination rate, as well as the barriers to this vaccination in young girls with CF. Sensitization of health care providers and of women on the importance of a regular and specific gynecological management, tailored to the particular context of CF should lead to improved practices
Thieurmel, Ronan. "Identification des conditions de rupture fragile des gainages combustibles en alliage de zirconium oxydés sous vapeur d’eau à haute température et trempés sous charge axiale". Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEM022/document.
Testo completoDuring hypothetical Loss-Of-Coolant-Accident (LOCA) scenarios, zirconium alloy fuel cladding tubes are subjected to severe thermo- mechanical loading conditions in highly oxidising chemical environments. Pressure and temperature evolution together with cooling water can lead to ballooning and burst followed by steam oxidation and hydrogen uptake at high temperature, and then axial loading during the final reflooding stage.This study focuses on the identification of mechanisms and key parameters which drive cladding fracture during the reflooding stage under axial tensile load.Laboratory-scale semi-integral tests simulating LOCA transients on Zircaloy−4 test rods have been realised. A fracture/no-fracture threshold of oxidation duration at high temperature has been determined. Two fracture locations have been identified: i) the burst zone with maximal oxidation and no hydrogen uptake, and ii) the “secondary hydriding” zone below the burst zone, with substantial hydrogen absorption and lower oxidation levels. Moreover, a scenario of fracture as a function of the reflooding chronology has been identified. Nevertheless, the macroscopic treatment of these tests has not permitted to discriminate these two fracture locations because fracture independently occurs in and out of the burst zone, whatever the applied transient and the balloon and burst morphologies.From systematic microstructural and fractographic characterisation of test specimens, a local approach aiming at identifying a fracture threshold as a function of the microstructural state of the material has been applied. The complex distribution of chemical elements and phases across the cladding thickness has been determined. Phase transformations in the highly-oxidised balloon, leading to a globally brittle microstructure have been explicated. In the secondary hydriding zone, a fracture threshold criterion has been identified by means of layer thickness measurements and hydrogen uptake profile
Caiulo, Davide. "Charge readout analysis in Liquid Argon Time Projection Chambers for neutrino and astro-particle physics". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1065/document.
Testo completoThis is an important period for High Energy Physics: many recent results, including the Higgs discovery and its characterization, confirm the Standard Model. A crucial point for the future of Particle Physics is the study of neutrino masses and mixing representing the first established evidence of physics beyond the SM. Since 2011, the large value of the ?13 mixing angle opened the way to the investigation of CP violation in the neutrino sector. A next generation long baseline neutrino experiment (DUNE) has unprecedented potential to precisely measure the neutrino oscillation parameters, determine the neutrino mass hierarchy and has a very good chance to discover evidence for CP violation in the leptonic sector. The large underground neutrino detectors needed for this task will also address the search for proton decay and the observation of supernovae neutrinos. Giant Liquid Argon Time Projection Chambers (LAr TPCs) will be employed as neutrino targets and detectors. They provide bubble-chamber quality imaging coupled to excellent energy resolution and particles identification capabilities. Neutrino interactions produce secondary particles, which ionize the liquid argon. The ionization electrons drift for long distances along a uniform electric field until they reach finely segmented and instrumented anodes, producing electrical signals that are used for 3D imaging and analysis of the primary interactions. The dual-phase readout technique foresees the amplification of the ionization signal in avalanches occurring in the gas phase above the liquid argon level. This technique further enhances the performance of the LAr TPC by increasing its signal to noise ratio. The subject of thesis is the ionization charge reconstruction and analysis in the dual-phase LAr TPC: the ionization charges measurement provides information about the kinetic energy of secondary charged particles produced in neutrino interactions. In this way, it is possible to reconstruct the incoming neutrino energy, identify and reject electromagnetic shower generated by photons from pi0 decay and perform particles identification from the measurement of the specific ionization losses.The measurement of the ionization implies a detailed knowledge of the detector response and of the reconstruction algorithm. In order to achieve this knowledge a detailed analysis of the simulated energy losses has been performed by studying the differences between the theoretical knowledge and the simulation
Fall, Meïssa. "Identification et caractérisation mécanique de graveleux latéritiques du Sénégal : application au domaine routier". Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL119N.
Testo completoRoubertie, François. "Identification de substrats arythmogènes et des mécanismes de décompensation dans une population de tétralogie de Fallot à l’âge adulte et perspectives de prise en charge ultérieure". Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0421/document.
Testo completoThe number of adults with a repaired tetralogy of Fallot is increasing. In the past, those patients were considered healed. Nonetheless, they present arrhythmogenic issues, with frequent sudden death, and mechanical complications: right ventricular dilation due to long lasting pulmonary valve regurgitation, secondary to surgical repair. The origin of arrhythmia and its interaction with right ventricular dysfunction is only partially understood. In this study, combining clinical with experimental data, we pointed out: 1) concerning the follow-up of this population, echocardiography is not a substitute to MRI 2) operative mortality of pulmonary valve replacement (PVR) still exists 3) a stentless bioprosthesis represents a valid solution for PVR 4) a valve repair is mandatory for severe tricuspid valve regurgitation at PVR 5) the genetic analysis carried out in an animal model of repaired tetralogy of Fallot, demonstrated the involvement of numerous genes in right ventricular remodeling 6) remodeling of the right ventricle in this animal model generates pro-arrhythmic substrate. Heart failure mechanisms in repaired tetralogy of Fallot are complex: a link between right ventricular dysfunction and arrhythmias is demonstrated. Further studies are needed to investigate other pro-arrhythmic mechanisms involving the left ventricle
Weiler, Christoph Karl Felix [Verfasser], e Hans Georg [Akademischer Betreuer] Bock. "Optimum Experimental Design for the Identification of Gaussian Disorder Mobility Parameters in Charge Transport Models of Organic Semiconductors / Christoph Karl Felix Weiler ; Betreuer: Hans Georg Bock". Heidelberg : Universitätsbibliothek Heidelberg, 2014. http://d-nb.info/1179925246/34.
Testo completoTheret, Laurent. "Identification, profil et prise en charge des deprimes des unites d'urgence des hopitaux generaux. A propos de 95 cas recueillis au chu de reims en 1991". Paris 6, 1994. http://www.theses.fr/1994PA066758.
Testo completoNazer, Rouba Al. "Système de mesure d'impédance électrique embarqué, application aux batteries Li-ion". Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENT007/document.
Testo completoEmbedded electrical impedance measurement is a key issue to enhance battery monitoring and diagnostic in a vehicle. It provides additional measures to those of the pack's current and cell's voltage to enrich the aging's indicators in a first time, and the battery states in a second time. A classical method for battery impedance measurements is the electrochemical impedance spectroscopy (EIS). At each frequency, a sinusoidal signal current (or voltage) of a variable frequency sweeping a range of frequencies of interest is at the input of the battery and the output is the measured voltage response (or current). An active identification technique based on the use of wideband signals composed of square patterns is proposed. Particularly, simulations were used to compare the performance of different excitation signals commonly used for system identification in several domains and to verify the linear and time invariant behavior for the electrochemical element. The evaluation of the estimation performance is performed using a specific quantity: the spectral coherence. This statistical value is used to give a confidence interval for the module and the phase of the estimated impedance. It allows the selection of the frequency range where the battery respects the assumptions imposed by the non-parametric identification method. To experimentally validate the previous results, an electronic test bench was designed. Experimental results are used to evaluate the wideband frequency impedance identification. A reference circuit is first used to evaluate the performance of the used methodology. Experimentations are then done on a Li–ion battery. Comparative tests with EIS are realized. The specifications are established using a simulator of Li-ion battery. They are used to evaluate the performance of the proposed wide band identification method and fix its usefulness for the battery states estimation: the state of charge and the state of health
Renault, Stéphane. "Application de l'automatique au contrôle actif d'écoulements pulsés". Poitiers, 1998. http://www.theses.fr/1998POIT2257.
Testo completoGhabach, Eddy. "Prise en charge du « copie et appropriation » dans les lignes de produits logiciels". Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4056/document.
Testo completoA Software Product Line (SPL) manages commonalities and variability of a related software products family. This approach is characterized by a systematic reuse that reduces development cost and time to market and increases software quality. However, building an SPL requires an initial expensive investment. Therefore, organizations that are not able to deal with such an up-front investment, tend to develop a family of software products using simple and intuitive practices. Clone-and-own (C&O) is an approach adopted widely by software developers to construct new product variants from existing ones. However, the efficiency of this practice degrades proportionally to the growth of the family of products in concern, that becomes difficult to manage. In this dissertation, we propose a hybrid approach that utilizes both SPL and C&O to develop and evolve a family of software products. An automatic mechanism of identification of the correspondences between the features of the products and the software artifacts, allows the migration of the product variants developed in C&O in an SPL The originality of this work is then to help the derivation of new products by proposing different scenarios of C&O operations to be performed to derive a new product from the required features. The developer can then reduce these possibilities by expressing her preferences (e.g. products, artifacts) and using the proposed cost estimations on the operations. We realized our approach by developing SUCCEED, a framework for SUpporting Clone-and-own with Cost-EstimatEd Derivation. We validate our works on a case study of families of web portals
Nlandu-Mputu, Madeleine. "Identification des enzymes intervenant dans le transfert des acides gras dans les végétaux : spécificité de ces enzymes vis-à-vis de la prise en charge d'acides gras inhabituels". Compiègne, 2009. http://www.theses.fr/2009COMP1847.
Testo completoBranched chain fatty acids are of particular interest for the oleo-chemical industry. The cloning of genes involved in their biosynthesis has led scientists toward the design of new high value oilseed crops. However, their research resulted in very modest accumulation in seeds (less than 25 %) due to a limited knowledge of the lipid metabolism and fatty acids transfer in plants. Ln this context, we aimed to better understand the hpid synthesis and storage in oilseed plants and particularly, the substrate specificity and selectivity of Kennedy pathway acyltransferases (G3PAT, LPAAT and DAGAT) which are required for the incorporation of these fatty acids into storage triacylglycerols. Dur assays demonstrated that the G3PAT of the three studied species (flaxseed, rapeseed and castor beau seed) show no specificity toward usual and unusual substrates incorporation at the sn-l position of the triacylglycerol. But, our study shows that LPAAT and DAGAT have a limited ability to incorporate branched chain fatty acids at the sn-2 and sn-3 positions of the triacylglycerol due to their low specific and sélective activities for unusual substrates. However, the flaxseed LPAAT present a cyclopropane acyl-CoA incorporation rate similar to that observed for the isolated and studied litchi LPAAT in this study. In addition, our results show that other alternative pathways (PDAT, CPT, PLA) exist in unusual fatty acid producing plants for their efficient accumulation into triacylglycerides such as must be the case of the castor bean to explain the high level hydroxy fatty acid in its seed oil. Successful production of high value oilseed crops depends on : i) the optimization of unusual fatty acid precursor production, ii) the identification of high selectivity enzymes and iii) a better knowledge of branched chain fatty acid transfer mechanisms into triacylglycerols
Demailly, Hélène. "Identification des coefficients aérodynamiques d'un projectile à partir de mesures prises en vol". Phd thesis, Université d'Orléans, 2011. http://tel.archives-ouvertes.fr/tel-00690639.
Testo completoMaurer, Julien. "Mesure des performances de reconstruction des électrons et recherche de Supersymétrie dans les canaux avec deux leptons de même charge dans les données du détecteur ATLAS". Phd thesis, Aix-Marseille Université, 2013. http://tel.archives-ouvertes.fr/tel-00952904.
Testo completoMaurer, J. "Mesure des performances de reconstruction des électrons et recherche de Supersymétrie dans les canaux avec deux leptons de même charge dans les données du détecteur ATLAS". Phd thesis, Aix-Marseille Université, 2013. http://tel.archives-ouvertes.fr/tel-00956354.
Testo completoLévêque, David. "Analyse de la tenue au délaminage des composites stratifiés : identification d'un modèle d'interface interlaminaire". Cachan, École normale supérieure, 1998. http://www.theses.fr/1998DENS0002.
Testo completoAbdennadher, Mohamed Karim. "Étude et élaboration d’un système de surveillance et de maintenance prédictive pour les condensateurs et les batteries utilisés dans les Alimentations Sans Interruptions (ASI)". Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10101/document.
Testo completoTo ensure power quality and permanently, some electronic system supplies exist. These supplies are the Uninterrupted Power Supplies (UPS). An UPS like any other system may have some failures. This can be a cause of redundancy loss. This load loss causes a maintenance downtime which may represent a high cost. We propose in this thesis to work on two of the most sensitive components in the UPS namely electrolytic capacitors and lead acid batteries. In a first phase, we present the existing surveillance systems for these two components, highlighting their main drawbacks. This allows us to propose the specifications which have to be implemented for this system. For electrolytic capacitors, we detail different stages of characterization ; the aging accelerated standard experimental procedure and their associated results. On the other hand, we present the simulation results of monitoring and failure prediction system retained. We discuss the experimental validation, describing the developed system. We detail the electronic boards designed, implemented algorithms and their respective constraints for a real time implementation. Finally, for lead acid batteries, we present the simulation results of the monitoring system adopted to obtain the SOC and SOH. We describe the aging experimental procedure of charging and discharging cycles of the batteries needed to find a simple and accurate electric models. We explain the aging experimental results and in the end we give suggestions for improving our system to get a more accurate SOH
Burgess, Craig Neilson. "Identification of a suspect before being charged: legitimate freedom of speech or a threat to a fair trial?" Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16178/1/Craig_Burgess_Thesis.pdf.
Testo completoBurgess, Craig Neilson. "Identification of a suspect before being charged: legitimate freedom of speech or a threat to a fair trial?" Queensland University of Technology, 2005. http://eprints.qut.edu.au/16178/.
Testo completoCourty, Alexis. "Architecture d'amplificateur de puissance linéaire et à haut rendement en technologie GaN de type Doherty numérique". Thesis, Limoges, 2019. http://www.theses.fr/2019LIMO0067/document.
Testo completoThe high capabilities of current and future 5G communication satellite links lead the processed signals in the payloads to simultaneously exhibit large amplitude variations (PAPR>10dB) and wide instantaneous bandwidths (BW>1GHz). Within the microwave transmission subsystem, the operation of the power amplification stage is highly constrained by the transmitted waveforms, it is one of the most energy-consuming module of the payload affecting as well the integrity of the transmitted signal. In this context, the functions dedicated to digital signal processing and currently implemented by the digital processor (such as filtering, channeling, and possibly the demodulation and regeneration of baseband signals) embedded in the payloads, represent a potential solution that would reduce the constraints reported on the power amplification function and help to manage the allocated power ressource. This work proposes a study on the capability of dual input power amplifier architectures in order to manage the efficiency-linearity trade-off over a wide bandwidth. This study is carried out on a 20W GaN Doherty demonstrator operating in C band. The combination of the output signals on the RF load is managed by an optimal amplitude and phase distribution that is digitally controlled at the input. Firstly, a wideband design methodology of Doherty amplifier is introduced and validated on a C band demonstrator. In a second time the experimental tool allowing the extraction of amplitude and phase input distributions is presented, the dual input characterization is achieved and compared with simulation results. Finally, in perspective of this work, a preliminary study of the capabilities of the digital Doherty for the management of an output load mismatch (VSWR management) is carried out and the results are put forward
Balma, Téegwendé Serge. "Caractérisation radioélectrique des satellites de télécommunications du futur". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLC018.
Testo completoNowadays, the radioelectric charac-teristics of satellites are directly measured by means of a com-pact range basis. However, the limits of these bases are affected by the growth of the satellite dimensions, in addition to the number and the complexity of the integrated an-tennas.On the other hand, near field techniques formed a promising solution under the planar range form. These techniques consist of measuring the radiated field near the source and accordingly deduce the far field by the means of mathemati-cal analysis.The purpose of this thesis is to adapt near field techniques for testing telecommunication satel-lites. In fact, these techniques are widelyused for antenna pattern measurements. However, a theoretical development has to be completed and measurement methods need to be proposed for testing all payload parameters. Unfortunately, specific difficulties related to the satellite function (transponder) and the limited access to antennas and satellite electronics have to be taken into account in the implementation of these measurement methodologies.Finally, the near field measurements are affected by many causes of errors. The identification of the error sources and the evaluation of their contribution to the final results constitute an important part of the thesis work. The global study allows dimensioning a complete measurement system with a good optimization
Turelli, Lorenzo. "Étude de nouveaux motifs d'espaceurs dans la construction de conjugués anticorps-médicaments". Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAF063.
Testo completoThe class of Antibody Drug Conjugates (ADCs) represents one of the most fast-growing treatments in oncology therapeutics, enabling the use of highly cytotoxic compounds covalently linked to a monoclonal antibody (mAb) which can selectively get attached to an antigen expressed on the surface of the cancer cell, assuring the precision of this therapy. The linker motif, connecting the mAb to the drug, is key to dictate the modality of the drug’s release as for the pharmacokinetic and pharmacodynamic of the whole conjugate. However, the development of a novel linker is a costly and time-consuming process, in which the ideal motif has to assure both the stability in blood circulation and a fast kinetic in the release of the warhead inside the cancer cell. The work here described aims at addressing the limitations present in this field in two different ways: first by introducing a novel acid sensitive cleavable linker with excellent extracellular stability and selective cleavability in the cancer cell; secondly, embracing a linker-less approach, by introducing a new format of ADC, coined Self Drugged Antibody (SDA), in which the drug is built on the mAb through a Ugi multicomponent reaction
RANGAMA, Jimmy. "Ionisation et excitation de l'atome de lithium par impact de particules chargées rapides : Identification des mécanismes de création de deux lacunes en couche K du lithium en fonction de la charge et de la vitesse du projectile". Phd thesis, Université de Caen, 2002. http://tel.archives-ouvertes.fr/tel-00002125.
Testo completoRangama, Jimmy. "Ionisation et excitation de l'atome de lithium par impact de particules chargées rapides : identification des mécanismes de création de deux lacunes en couche K du lithium en fonction de la charge et de la vitesse du projectile". Caen, 2002. http://www.theses.fr/2002CAEN2041.
Testo completoNuemi, Tchathouang Gilles Eric. "Identification des profils de changement sur données longitudinales, illustrée par deux exemples : étude des trajectoires hopsitalières de prise en charge d'un cancer. Construction des profils évolutifs de qualité de vie lors d'un essai thérapeutique pour un cancer avancé". Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOMU02/document.
Testo completoContext In healthcare domain, data mining for knowledge discovery represent a growing issue. Questions about the organisation of healthcare system and the study of the relation between treatment and quality of life (QoL) perceived could be addressed that way. The evolution of technologies provides us with efficient data mining tools and statistical packages containing advanced methods available for non-experts. We illustrate this approach through two issues: 1 / What organisation of healthcare system for cancer diseases management? 2 / Exploring in patients suffering from metastatic cancer, the relationship between health-related QoL perceived and treatment received as part of a clinical trial. Materials and methods Today we have large databases. Some are dedicated to gather together all hospital stays, as is the case for the national medico-administrative DRG-type database. Others are used to store information about QoL perceived by patients, routinely collected in clinical trials. The analysis of these data was carried out following three main steps: In the first step, data are prepared to be useable according to a defined concept of data analysis. For example, a classical database (patient-centered) was converted to a new database organised around a new defined entity which was different from the patient (eg. Care trajectory). Then in the second step, we applied data mining methods for knowledge discovery: we used the formal analysis of concepts method and unsupervised clustering techniques. And finally the results were presented in a graphical form. Results Concerning the question of the organisation of healthcare system, we constructed a typology of hospital care trajectories. We were able then to describe current practice in the management of cancers from the first cancer related surgical operation until one year of follow-up. In the case of breast cancer, we’ve described a typology of care on the basis of hospital costs over a one year follow up. Concerning the second question, we have also constructed a typology of QoL change patterns. This comprised three groups: Improvement, stability and degradation group.Conclusion The main interest of this work was to highlight new thoughts, which advances understanding and, contributing in appropriate solutions building