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Tesi sul tema "IgE"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Suzuki, Lisandra Akemi. "Resposta imune humoral na neurocisticercose." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308741.

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Orientador: Claudio Lucio Rossi<br>Tese (doutorado) - Universidade Estadual de Campinas. Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-15T09:51:57Z (GMT). No. of bitstreams: 1 Suzuki_LisandraAkemi_D.pdf: 1217880 bytes, checksum: 4ceb1f773f112c88145bc69e02976ef2 (MD5) Previous issue date: 2010<br>Resumo: A neurocisticercose (NC) e uma importante causa de doença neurológica em muitos paises em desenvolvimento, incluindo o Brasil. O diagnostico clinico da NC e dificultado pelo polimorfismo e pela não especificidade dos sintomas. As tecnicas de neuroimagem e pesquisa de an

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2

Hjelm, Fredrik. "Early Immunostimulatory Effects of IgE- and IgG Antibodies." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7209.

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3

Renault, Neil. "Construction, method development and comparative testing of an 'All-Diet' protein microarray to measure IgA, IgM, IgG and IgE in human sera and milk." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503929.

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Existing immunoglobulin (Ig) tests only give a limited picture of the immunological response to food antigens. Furthermore, existing tests require large volumes of sample, over a limited number of foods, are not amenable to a high sample through-put system and the results are limited to normally just one immunoglobulin class. In order to investigate the global immune response towards food products we have developed the "all diet" microarray concept. The "all-diet food protein microarray contains extracts of over 400 food ingredients that cover most of the food products found in the UK. Using t

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4

Gilbert, Sophie. "Studies on feline IgE." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/29776.

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Ten normal cats were immunised with <I>Dermatophagoides farinae </I>(DF) antigen and intradermal skin tests (IDSTs) were performed weekly. Sera from the latter were also assessed for DF-specific IgE by ELISA and PK tests. Detectable DF-specific IgE was induced in all of the 10 cats, however levels were found not to be correlated with the development of positive IDSTs nor with the levels of IgE as assessed by PK tests. Sera from 10 cats with symptoms consistent with atopy, from 15 normal household cats and from 11 laboratory maintained cats were assessed for allergen-specific IgE and IgG to DF

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5

Ding, Zhoujie. "Feedback Enhancement of Immune Responses by IgE, IgM, and IgG3 Antibodies." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-237337.

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Antibodies can enhance or suppress the immune responses against their specific antigens. This phenomenon is known as antibody-mediated feedback regulation. We have studied the mechanisms underlying IgE-, IgM-, and IgG3-mediated enhancement of immune responses in mouse models using intravenous immunization. We attempted to answer the following questions: 1) Which cell type presents IgE-complexed antigens to CD4+ T cells? 2) Is complement activation required for specific IgM to enhance antibody responses? 3) Does IgM enhance CD4+ T-cell responses? 4) How are IgG3-antigen complexes transported in

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6

Ashburn, David. "The relevance of IgA and IgE assays, IgG avidity and western blotting in the diagnosis of Toxoplasma infection." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361776.

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To improve diagnosis of <I>Toxoplasma gondii</I> in difficult patient groups, IgA- and IgE-immunosorbent agglutination assays (ISAGA), IgG avidity and Western blotting were developed and assessed. In the ISAGA, rabbit anti-human IgA or anti-human IgE (for the IgA-ISAGA and IgE-ISAGA respectively) was adsorbed onto microtitre plates; formaldehyde fixed tachyzoites were used to identify specific antibody. Both ISAGAs were specific; only 1/482 (0.2%) and 1/513 (0.19%) false positive results were recorded for the IgA and IgE-ISAGA respectively. Both were produced early in infection and were detect

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7

Zimmer, Anja. "Futtermittel-spezifisches IgG und IgE vor und nach Eliminationsdiäten bei allergischen Hunden." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-148673.

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8

Guerra, Fernanda Garcia. "Anticorpos igg e ige para auto-antígenos nucleares no lúpus eritematoso sistêmico." Instituto de Ciências da Saúde, 2005. http://repositorio.ufba.br/ri/handle/ri/21734.

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9

Bracher, Marguerite. "IgE in immunotherapy of cancer." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/ige-in-immunotherapy-of-cancer(08abceea-54a8-436c-9504-24742d57538d).html.

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10

Karnowski, Alexander. "Post-transcriptional regulation of IgE." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10990069.

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11

Kirak, Oktay. "Eliminierung IgE-positiver B Lymphozyten mit Hilfe eines rekombinanten bispezifischen anti-IgE/anti-CD3 Antikörpers." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-122571.

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12

Ledin, Anna. "More or Less IgE : Therapeutic Vaccines, Adjuvants and Genes and Their Effect on IgE Levels." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4254.

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13

Housden, Jonathan E. M. "Lys 352 in human IgE is a major effector determinant residue in IgE-CD23 interaction." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443882.

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14

Yahya, Mohd Norhakim. "Analysis of the IgE network : inhibition of CD23-mediated IgE upregulation and CD21/C3d interaction." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:bc5ff165-2d2c-4e4f-a0e9-5651cacd2ddf.

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Allergic reactions are mainly mediated by the interactions between the IgE and its ligands, amongst them CD23 and CD21 in what is termed the IgE network. CD23 is involved in upregulating IgE expression by forming a trimolecular complex with CD21 and IgE on the B-cell surface, resulting in the specific activation of IgE-positive B cells. CD21 also interacts with C3d and is a bridge between the innate and the immune system. A crystal structure of the interaction has been solved (Szakonyi et al., 2001) but was controversial because it contradicted previous biochemical analyses. The aims of this t

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15

Muntwyler, Jeannette. "Specific antibodies against a recombinant equine IgE heavy chain fragment recognizing native horse serum IgE /." [S.l.] : [s.n.], 1997. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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16

Griot-Wenk, Monika. "Charakterisierung von IgE beim Hund mit Ausblick auf die Bedeutung von IgE bei chronischen idiopathischen Gastroenteropathien /." Bern : [s.n.], 2000. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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17

Zwahlen, Roger Arthur Stucki Marco Viktor. "Basophil histamine release and leukotriene production in response to anti-IgE and Anti IgE-receptor antibodies /." Basel : Karger, 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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18

Vernersson, Molly. "The rise and fall of IgE." Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2597.

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<p>Immunoglobulin E (IgE) occurs exclusively in mammals and is one of five immunoglobulin (Ig) classes found in man. Unlike other isotypes, IgE is best known for its pathological effects, whereas its physiological role remains somewhat elusive. </p><p>To trace the emergence of IgE and other post-switch isotypes we have studied Ig expression in two monotreme species, the duck-billed platypus (<i>Ornithorhynchus anatinus</i>) and the short-beaked echidna (<i>Tachyglossus aculeatus</i>), leading to the cloning of IgE, two IgG isotypes in platypus and echidna IgE. The presence of IgE and the con

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19

Thienes, Cortlandt Paul. "Studies on the regulation of IgE." Thesis, King's College London (University of London), 1998. https://kclpure.kcl.ac.uk/portal/en/theses/studies-on-the-regulation-of-ige(7b8d519e-0c0e-4a5a-80d8-5ba000d104ec).html.

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20

Koers, Alexander Magnus Maria. "Radiolabelling and biodistribution of IgE antibodies." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/radiolabelling-and-biodistribution-of-ige-antibodies(08a7505b-018b-4bf9-a23f-d31b2432d07a).html.

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Antibodies used for cancer treatment and immune therapy have, to date, been of the IgG class. Efficacy might be improved by using the IgE class of antibodies as these have higher affinity for their Fc-receptors. IgE has a greater tissue penetration and longer half-life in tissue and IgE bound to IgE-receptor-expressing effector cells is thought to actively infiltrate tumours. IgE has not been subject of in vivo imaging studies to date. Objectives: The aim was to radiolabel both anti-CSPG4-IgE and MOV18-IgE, and their IgG counterparts targeted to the same antigen, while maintaining the function

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21

Pachlopnik, Jana Maria. "Antigen induced conformational change in IgE /." [S.l.] : [s.n.], 1998. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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22

Helbling, Arthur. "IgE-vermittelte Allergien: Ursache und Diagnostik /." [Bern] : [Universität Bern], 2000. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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23

Palhas, Priscila Botelho. "IgE para ácaros, barata e Ascaris lumbricoides: impacto na IgE total e implicações para o desenvolvimento de alergia e asma." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-19072018-095431/.

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A imunoglobulina E (IgE) tem papel central na patogênese das doenças alérgicas. É parte da resposta do tipo 2, e as citocinas IL-4 e IL-13 são essenciais para que haja produção deste isotipo de imunoglobulina. Produção de IgE é também induzida por parasitas intestinais, particularmente helmintos. O objetivo do presente estudo foi avaliar a contribuição de IgE específica para ácaros, barata, gato, cachorro e para o parasita Ascaris lumbricoides sobre os níveis de IgE total entre crianças de áreas distintas no Brasil. Anticorpos IgE para ácaros Dermatophagoides pteronyssinus e Blomia tropicalis;

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24

Zhang, Jie Wei. "Investigation of IgE and IgG epitopes on ovomucoid using egg-white allergic patients' sera." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ40451.pdf.

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25

Huang, Xinyuan [Verfasser]. "Evolution of serum IgE and IgG antibodies to 35 molecules in childhood / Xinyuan Huang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1179778111/34.

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26

Mancardi, David. "Rôles pro-inflammatoires des RFcγIV murins, et de leurs deux équivalents fonctionnels humains, les RFcγI et les RFcεI(αγ)". Paris 6, 2009. http://www.theses.fr/2009PA066504.

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Un nouveau RFc, nommé RFcγIV, a été récemment cloné. Ce sont des RFc activateurs murins pour les IgG2 exprimés par les macrophages et les neutrophiles. Ils n’existent pas chez l’homme. Nous avons caractérisé des propriétés biologiques de ces RFc et recherché s’ils avaient des équivalents fonctionnels humains. Nous avons mis en évidence une interaction de faible affinité entre les RFcγIV et les IgE. Cette interaction participe à l’induction d’une inflammation pulmonaire. Dans des modèles d’inflammation dépendante des IgG, les RFcγIV sont capables d’induire une arthrite auto-immune et des chocs

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27

Bowles, Sandra Lyn. "An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1231.

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Type I hypersensitivities are mediated by the IgE antibody. The effector functions and synthesis of IgE result from interactions with a network of proteins that include a high affinity (FcRIα) and a low affinity (CD23, FcRII) Fc receptor in conjunction with the B lymphocyte receptor, CD21. CD23 is a multifunctional type II transmembrane protein that binds its known ligands through its ectodomain either as a membrane-bound or soluble receptor generated in vivo by specific proteolytic cleavages. IgE production is primarily regulated by interactions between IgE, CD23 and CD21. Despite its importa

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28

Luz, Johanna Da. "Aspects of N-glycosylation in human IgE /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-130-6.

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29

Quinn, Phyllis Mary. "The structure and function of IgE-tailpiece." Thesis, University of Nottingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444655.

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30

Corfield, Gaynor Christa. "The regulation and characterization of porcine IgE." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319081.

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31

Asai, Koichi. "Regulation of mast cell survival by IgE." Kyoto University, 2002. http://hdl.handle.net/2433/149705.

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32

Yu, Yan. "Anti-IgE autoantibodies in bee venom allergy /." [S.l.] : [s.n.], 1991. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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33

Machado, Fernando Osni. "Tabagismo materno e IgE no cordão umbilical." reponame:Repositório Institucional da UFSC, 1995. http://repositorio.ufsc.br/xmlui/handle/123456789/76218.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias da Saude<br>Made available in DSpace on 2012-10-16T08:22:12Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-08T19:26:34Z : No. of bitstreams: 1 101681.pdf: 3505184 bytes, checksum: 09b9d59fd408db6c1062007e4db0090b (MD5)<br>Objetivo: Analisar a influência do tabagismo materno nos níveis de IgE do sangue do cordão umbilical dos recém nascidos (RN). Local: O estudo desenvolveu-se na Maternidade Escola da UFSC (Maternidade Carmela Dutra) em Florianópolis, Santa Catarina. Sujeitos: Investigou-se 492 RN e resp

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34

Neiss, Anne-Catherine. "La regulation de la production des ige." Strasbourg 1, 1987. http://www.theses.fr/1987STR10767.

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35

Balbino, Bianca. "Characterizing the role of IgG antibodies in anaphylaxis." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS024.

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L'anaphylaxie est la manifestation clinique la plus sévère de l’allergie. Il est couramment admis que chez l’homme, l’anaphylaxie est médiée par les anticorps de type IgE. Cependant, des données chez la souris indiquent que les IgG peuvent également contribuer à l’anaphylaxie. Le but de ma thèse a été de mieux comprendre comment les IgG induisent l’anaphylaxie. Dans un premier temps, nous avons démontré que les IgG murines induisent l’anaphylaxie en activant le récepteur FcγRIII à la surface des macrophages, ce qui aboutit à la libération de PAF. Nous avons ensuite voulu savoir si les IgG huma

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36

Montagnac, Guillaume. "Etude du rôle du récepteur de faible affinité aux IgE, CD23, dans le transport transépithélial de complexes IgE/allergènes." Paris 5, 2005. http://www.theses.fr/2005PA05N11S.

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Le récepteur de faible affinité aux IgE (CD) est impliqué dans le transport transépithélial de complexes IgE / allergène. Au niveau intestinal, ce transport est à l'origine du déclenchement allergique. Mon travail de thèse a visé à étudier le rôle du CD23 dans ce processus. Nous avons établi que les cellules épithéliales intestinales murines expriment la forme CD23b ainsi qu'une nouvelle forme épissée, bDELTA5, dont l'expression est induite par la sensibilisation in vivo. La régulation de l'internalisation du CD23 murin est complexe, faisant intervenir des domaines intra et extracellulaires. N

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37

Dupuy, Michèle. "Intérêt des IgE et de IgA anti-toxoplasma gondii dans le diagnostic sérologique de la toxoplasmose." Bordeaux 2, 1993. http://www.theses.fr/1993BOR23036.

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38

Renner, Eleonore D. "Klinisch-genetische Definition des Hyper-IgE-Syndroms (HIES)." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-1763.

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39

Stöberl, Christian. "Gene-Targeting zur Herstellung einer IgE überexprimierenden Maus." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-10405.

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40

Nilsson, Caroline. "Cytokine profiles, infections and IgE sensitisation in childhood /." Stockholm : Department of Clinical Science and Education, Södersjukhuset : Sachs' Children's Hospital : Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-720-0/.

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41

Shi, Jianguo. "Interaction of human CD23 with IgE and CD21." Thesis, King's College London (University of London), 1997. https://kclpure.kcl.ac.uk/portal/en/theses/interaction-of-human-cd23-with-ige-and-cd21(373685f2-b918-4cae-9404-c10d226ff134).html.

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42

Smith, Susan Jayne. "The molecular pathology of human autoanti-IgE antibodies." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294568.

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Lai, Catherine Li. "Regulatory Immune Mechanisms in IgE-Mediated Food Allergies." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27352.

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Background Egg allergy is an IgE-mediated food allergy affecting 10% of Australian infants. Two Australian early egg introduction trials were conducted – Beating Egg Allergy Trial (BEAT) and Start Time of Egg Protein to Prevent Egg Allergy (STEP). Both studies showed significant induction of egg-specific IgG4 that was associated with early egg consumption. IgG4 is associated with tolerance induction. However, the mechanisms of tolerance acquisition are still poorly understood but may involve regulatory T and B cells. Aims To examine the antigen‑specific and non‑specific immune cell su

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44

Ilkow, Veronica Franciszka. "Engineering IgE antibodies and CD23 for therapeutic discovery." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/engineering-ige-antibodies-and-cd23-for-therapeutic-discovery(54f73d64-5c16-42c4-9dea-42855873eeb6).html.

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Immunoglobulin E (IgE) is fundamental to the allergic response and the functions of IgE are mediated by its Fc region binding to two receptors, FcεRI and CD23 (FcεRII). The interaction of IgE with other proteins have complicated our investigations of the unique role each receptor plays. To solve this, a small-scale library of IgE-Fc proteins was designed with two key positions, one at each receptor-binding site mutated. The unpredictable allosteric nature of IgE prevents rational engineering approaches, thus the design of a membrane-bound IgE-Fc-GFP-tagged protein allowed for the generation of

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45

Worm, Margitta. "Mechanismen der CD40/IL-4-abhängigen IgE-Regulation." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13716.

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IgE ist das Schlüsselmolekül Typ-I allergischer Erkrankungen.. Die Produktion von IgE wird durch die Interaktion des Oberflächenmoleküls CD40 auf B-Zellen mit seinem Liganden (CD40L), dass von aktivierten T-Zellen exprimiert wird, sowie über Signale durch die Zytokine IL-4 oder IL-13 von B-Zellen produziert. Die CD40/IL-4-abhängige IgE-Produktion in vitro kann einerseits als Modell zum Verständnis der Entstehung allergischer Erkrankungen eingesetzt werden; andererseits können potenziell therapeutisch wirksame Substanzen untersucht werden. Untersuchungen zum Verständnis allergischer E

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Lindner, Juliane. "Immunmodulation der IgE-Produktion durch autokrine Calcitriol-Synthese." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2017. http://dx.doi.org/10.18452/17768.

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Aktuelle Studien legen nahe, dass ein niedriger Vitamin D-Status assoziiert mit steigenden Breitengraden, mit dem Auftreten von Autoantikörpern und damit einhergehenden Autoimmunerkrankungen positiv korreliert. Trifft UV-B-Strahlung auf die Haut, entsteht aus 7-Dehydrocholesterol nach enzymatischen Prozessen in Leber und Niere, die bioaktive Form von Vitamin D, 1α,25-Dihydroxyvitamin D3 (Calcitriol). Den finalen Stoffwechselschritt katalysiert die 1α-Hydroxylase CYP27B1. Die biologische Wirkung von Calcitriol wird über dessen Bindung an den nukleären Vitamin D-Rezeptor vermittelt, was letztlic

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47

DONADINI, VERONIQUE. "Regulation de la synthese des ige : donnees recentes." Strasbourg 1, 1993. http://www.theses.fr/1993STR15047.

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48

Yenagi, V. A. "GENERATION OF A TRANSGENIC FCRI-KO/ HIGH IGE-PRODUCER MOUSE TO ELUCIDATE THE ROLE OF IGE IN TUMOR SURVEILLANCE." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/221195.

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Abstract (sommario):

Immunoglobulin E (IgE) is a powerful elicitor of anti-parasitic immunity and play a key role in pathophysiology of allergic reactions.IgE antibodies acts by engaging both high and low affinity receptors, FcεRI and CD23. Since the 1960s a number of epidemiological studies have investigated the potential association between a history of allergy and risk of malignancy. In this direction studies were planned by redirecting the power of the IgE system towards tumors, and to evaluate if it can trigger powerful anti-tumor cytotoxic activities. Previously in our laboratory,mouse and human IgE have bee

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49

Guiyedi, Vincent. "Etude des anticorps auto-réactifs produits au cours de l'infection par Plasmodium falciparum : implication dans la protection ou la pathogenèse du neuropaludisme." Paris 6, 2006. http://www.theses.fr/2006PA066507.

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Abstract (sommario):

Les études antérieures traitant du rôle des auto-anticorps dans la protection ou la pathogenèse du paludisme grave sont peu nombreuses. Notre approche consiste a analyser l’auto-réactivité globale des IgG et des IgE au cours de l’infection par P. Falciparum, chez des patients vivant en zone d’endémie palustre repartis en cinq groupes: patients non infectés par P. Falciparum (NI), porteurs asymptomatiques (IA), accès palustre simple (AS), accès palustre graves sans atteinte neurologique (AG), neuropaludisme (NP). Nos résultats mettent en évidence une réponse auto-réactive des IgG associée aux c

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50

Zimmer, Anja [Verfasser], and Rafl [Akademischer Betreuer] Müller. "Futtermittel-spezifisches IgG und IgE vor und nach Eliminationsdiäten bei allergischen Hunden / Anja Zimmer. Betreuer: Rafl Müller." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027066127/34.

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