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Tesi sul tema "IL-10"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Frisch, Kristina. "Klonierung von IL-10 und IL-10-Homologen und Funktionsanalyse in einem Mausmodell der polymikrobiellen Sepsis." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973392185.

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2

Ng, Tien Haeng Sky. "Mechanisms of IL-10 transcriptional regulation." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702135.

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Previous work has shown that subcutaneous (s.c) specific immunotherapy (SIT) using the myelin protein peptide MBP Acl-9 [4Y] induces protection against EAE in the TCR transgenic Tg4 mice. Repeated administration of MBP Ac1-9 [4Y] was found to induce IL-1O expressing TH1 like cells which were termed IL-l0 Tregs. To further the understanding of how IL-1O transcription is regulated, the expression of IFN-y, IL-4, IL-1O, c-Maf, NFIL3 protein and mRNA, Gata3 mRNA and epigenetic modifications at the Il10 promoter were characterised for each dose of s.c MBP Ac 1-9 [4 Y] administration. The analysis r

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3

Cordeiro, Cynthia Azeredo. "Polimorfismos dos Genes das Citocinas IL-1alfa, IL -1beta, IL-10 e TNF-alfa." Universidade Federal de Minas Gerais, 2008. http://hdl.handle.net/1843/RRSA-7F5KG7.

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Purpose: Toxoplasmic Retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in many parts of the world. There is a great controversy regarding which factors are responsible for the occurrence or reccurrence of TR. Experimental data have demonstrated a relevant role for IL-10, TNF-alfa, IL-1alfa and IL-1alfa in the modulation of acute ocular toxoplasmosis. Therefore, we aim to investigate thepossible association between an IL10 (-1082G/A), TNF-alfa (-308G/A), IL1A (-889C/T) and IL1B (+3954C/T) gene polymorphisms and TR in humans. Methods: One hundred patients with dia

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4

Wong, Li-Chuen. "IL-10 promoter polymorphisms in atopic dermatitis." Thesis, The University of Sydney, 2002. https://hdl.handle.net/2123/27849.

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Atopic dermatitis (AD) is one of the many clinical manifestations of atopy. It is one of the most common chronic inflammatory skin diseases with increasing prevalence over the last century. The aetiology of this disease is multifactorial with a complex interaction of genetic, environmental and immunologic factors.

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Saramago, Eduardo Alves. "O hidrogênio molecular potencializa a hipotermia e previne a hipotensão e a febre durante a inflamação sistêmica induzida por LPS." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17134/tde-07022019-140036/.

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O hidrogênio molecular (H2) exerce efeito antioxidante, anti-apoptótico e antiinflamatório. Nesse estudo testamos a hipótese que o H2 modula as mudanças cardiovasculares, inflamatórias e termorregulatórias na inflamação sistêmica (IS) induzida por lipopolissacarídeo (LPS) em diferentes doses (0,1 ou 1,5 mg/kg, intravenoso, induzindo IS moderada ou severa) em ratos machos Wistar (250-300 g). LPS ou salina foi injetada imediatamente antes do início dos 360 minutos de inalação do H2 (2% H2, 21% O2, balanceado com nitrogênio) ou ar ambiente (21% O2, balanceado com nitrogênio). A temperatura corpor

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6

Vale, Mariana Lima. "Atividade analgesica das interleucinas 4, 10 e 13 (IL-4, IL-10 e il-13) na dor inflamatoria experimental : papel de celulas residentes e citocinas." reponame:Repositório Institucional da UFC, 2000. http://www.repositorio.ufc.br/handle/riufc/2569.

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VALE, Mariana Lima. Atividade analgesica das interleucinas 4, 10 e 13 (IL-4, IL-10 e il-13) na dor inflamatoria experimental : papel de celulas residentes e citocinas. 2000. 140 f. Dissertação (Mestrado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, 2000.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-05-04T12:19:28Z No. of bitstreams: 1 2000_dis_mlvale.pdf: 664941 bytes, checksum: a8df00b6a53f2d6632ebe816657800aa (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-05-04T12:36:24Z (GMT) No. of bitstreams: 1 2000_

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7

Costa, Tânia Alves da. "A função da IL-10 na paracoccidioidomise pulmonar murina." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-16122010-113911/.

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O principal mecanismo de defesa de hospedeiros infectados pelo Paracoccidioides brasiliensis (Pb), fungo dimórfico que causa a mais importante micose sistêmica da América Latina, é a imunidade celular. Neste processo participam macrófagos ativados por IFN-<font face=\"Symbol\">g e a IL-10 parece ser a citocina que se contrapõe a esta ativação. Tanto na patologia humana como em modelos experimentais há fortes indicações de que a IL-10 age como supressora da imunidade celular causando efeitos deletérios aos hospedeiros; entretanto, estudos diretos sobre a função da IL-10 na paracoccidiodomicose

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8

Cirocco, Robert E. "Cytokine analisys in atlantic bottlenose dolphins: molecular characterization of IL-4, IL-6, and IL-10." FIU Digital Commons, 2001. http://digitalcommons.fiu.edu/etd/2370.

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The health status of wild and captive Atlantic Bottlenose dolphins (Tersiops truncatis) is difficult to ascertain. Mass strandings of these animals have been attributed to pollutants, as well as bacterial infections. Using human Enzyme Linked Immuno-Assays (ELISA) for immunological cytokines, I measured soluble cytokine levels with respect to their health status. In a retrospective analysis of dolphin sera, there was a trend of higher cytokine levels in “sick” animals. I cultured dolphin lymphocytes in the presence of a mitogen (PHA), a super antigen (Staph-A), Lipopolysaccharide (LPS), and a

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9

Mitchell, Ruth Elizabeth. "Regulation of IL-10 in CD4+ T cells." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.691167.

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10

OLIVEIRA, Gabriela Almeida de. "Polimorfismos de citocinas (TNF-A, IL-10 e IL-17) no câncer gástrico." Universidade Federal do Pará, 2016. http://repositorio.ufpa.br/jspui/handle/2011/7251.

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Submitted by Cássio da Cruz Nogueira (cassionogueirakk@gmail.com) on 2017-01-05T11:27:08Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_PoliformismosCitocinasCancer.pdf: 4538726 bytes, checksum: a9402888128957139063bdb3b7fd849e (MD5)<br>Approved for entry into archive by Edisangela Bastos (edisangela@ufpa.br) on 2017-01-09T17:13:32Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_PoliformismosCitocinasCancer.pdf: 4538726 bytes, checksum: a9402888128957139063bdb3b7fd849e

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OLIVEIRA, Jacqueline Flores de. "Níveis séricos de interleucinas IL-6 e IL-10 em indivíduos com transtorno de estresse pós-traumático em uma amostra de base populacional." Universidade Catolica de Pelotas, 2018. http://tede.ucpel.edu.br:8080/jspui/handle/jspui/691.

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Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2018-05-03T12:31:50Z No. of bitstreams: 1 JACQUELINE FLORES DE OLIVEIRA 2018.pdf: 1047235 bytes, checksum: aa5d647bf60bee68ec295537b66e13f6 (MD5)<br>Made available in DSpace on 2018-05-03T12:31:50Z (GMT). No. of bitstreams: 1 JACQUELINE FLORES DE OLIVEIRA 2018.pdf: 1047235 bytes, checksum: aa5d647bf60bee68ec295537b66e13f6 (MD5) Previous issue date: 2018-01-04<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq#<br>#-2555911436985713659#<br>#600<br>Post-traumatic stress disorder (PTSD) is a psychiatric

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12

Beigel, Florian. "Die Bedeutung der IL-10-verwandten Zytokine IL-22, IL-28A und IL-29 bei intestinaler Entzündung und viraler Infektion." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-80038.

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13

Shoemaker, John. "Molecular mechanisms for the regulation of the Il-10 gene in CD4 T cells : comparison of IL-10-Treg and CD25+Treg." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427840.

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14

Assrafally, Farryah. "Modulation of pathological cardiac hypertrophy via the interleukin-10 signalling in the cardiomyocytes." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/modulation-of-pathological-cardiac-hypertrophy-via-the-interleukin10-signalling-in-the-cardiomyocytes(430247dd-1512-4e29-9f7a-288bae85fffd).html.

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Inflammation plays a key role during pathological hypertrophy and heart failure. Whilst the roles of pro-inflammatory cytokines are relatively well understood, little is known about the anti-inflammatory cytokines in the heart. Interleukin-10 (IL-10) is a major anti-inflammatory cytokine that is expressed in the heart and may play a crucial role during cardiac remodelling. IL-10 exerts its function by binding to the IL-10 receptor (IL-10R). The primary aim of the PhD study was to investigate the effects of the ubiquitous ablation of IL-10R1 gene during pressure overload induced hypertrophy and

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15

Pathania, Uday Singh. "Cloning and characterisation of the chicken IL-10 family." Thesis, Royal Veterinary College (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522707.

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16

Ghanipour, Ali. "IL-10 regulates macrophage activation through activation of SHIP." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/30873.

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IL-10 is a potent anti-inflammatory and immunosuppressive cytokine, which regulates macrophages by activation of the STAT3 pathway. However, several lines of evidence suggest that IL-10 can inhibit macrophage activation independent of STAT3 through currently unknown mechanisms and pathways. Here for the first time, we show that in murine macrophages, IL-10 activates Src Homology 2 Domain-containing Inositol 5'-Phosphatase (SHIP), a molecule with reported anti-inflammatory effects. Activation of SHIP by IL-10 is required for inhibition of Tumor necrosis factor alpha (TNFα) in macrophages

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17

Perona-Wright, Georgia. "The influence of IL-10 on dendritic cell activation." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/25073.

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Dendritic cells (DCs) are the watchmen of the immune system. They survey the peripheral tissues and display samples of surrounding antigens for inspection by T cells. Pathogenic or inflammatory signals trigger DCs to mature, upregulating their expression of MHC and costimulatory molecules and converting them into potent T cell stimulators. The character of the activated DC depends not only on the stimulus but also on concomitant environmental signals. This thesis tests the hypothesis that in vitro manipulation of DC function can be used to direct immune responses in vivo. The work focuses on t

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18

SERAFINI, GIORGIA. "IL-10 mediated immunological tolerance: preclinical and clinical studies." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1022.

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Thalassemia Major can be cured with allogeneic hematopoietic stem-cell transplantation (HSCT). Persistent mixed chimerism (PMC) develops in around 10% of transplanted thalassemic patients, but the biological mechanisms underlying this phenomenon are poorly understood. IL-10 is an immunomodulant cytokine that plays a central role in controlling inflammation, down-regulating immune responses, and inducing immunological tolerance. Detection of high levels of IL-10, produced by PBMCs of patients with PMC, in comparison to those of patients with complete donor chimerism (CC) or normal donors (ND),

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19

Lombard, Robin. "Rôle des polynucléaires neutrophiles dans la régulation de la réponse inflammatoire IL-17A lors de l'infection pulmonaire par les mycobactéries." Thesis, Tours, 2013. http://www.theses.fr/2013TOUR4048/document.

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La pandémie de tuberculose (TB) causée par Mycobactérium tuberculosis (Mtb) n’est pas contrôlée par le vaccin vivant BCG. Mtb induit la formation de granulomes qui évoluent vers une réaction inflammatoire exacerbée détruisant le poumon lors de la TB active. Les rôles des polynucléaires neutrophiles (PNN) et de la cytokine inflammatoire IL-17A dans cette évolution sont à clarifier. Nous montrons, chez la souris, que les PNN sont recrutés dans le poumon en deux vagues après infection par Mtb ou BCG. La deuxième vague dépend du récepteur IL-17RA exprimé par les cellules non-hématopoïétiques. Les

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20

Vilela, Josie Fadul 1982. "Investigação dos polimorfismos dos genes da interleucina-1 (IL-1), IL1RN, IL-4, IL-6 e IL-10 em pacientes adultos portadores de púrpura trombocitopênica imune = Investigation of interleukin-1 (IL-1), IL1RN, IL-4, IL-6 and IL-10 gene polymorphism adult patients with immune thrombocytopenic purpura." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310653.

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Orientador: Marcelo Addas Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T03:08:54Z (GMT). No. of bitstreams: 1 Vilela_JosieFadul_M.pdf: 1739915 bytes, checksum: ea1d6c47907a49ccd0e00255b01d3dee (MD5) Previous issue date: 2012<br>Resumo: A Púrpura Trombocitopênica Imune (PTI) é uma doença autoimune caracterizada pela presença de autoanticorpos contra as glicoproteínas de membrana plaquetária, tais como GPIIb/IIIa e GPIb/IX. O processo patogênico da PTI envolve uma destruição acelerada das plaqueta

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21

Beigel, Florian [Verfasser]. "Die Bedeutung der IL-10-verwandten Zytokine IL-22, IL-28A und IL-29 bei intestinaler Entzündung und viraler Infektion / Florian Beigel." München : Universitätsbibliothek München, 2008. http://d-nb.info/1006744843/34.

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Піддубна, Анна Іванівна, Анна Ивановна Поддубная, Anna Ivanivna Piddubna, Микола Дмитрович Чемич, Николай Дмитриевич Чемич та Mykola Dmytrovych Chemych. "Прогностичне значення алельного поліморфізму генів IL-4, IL-10, TNF-α у ВІЛ-інфікованих осіб". Thesis, Укрмедкнига, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32436.

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З’ясовано взаємозв’язок розподілу алельних варіантів генів IL-4, IL-10, TNF-α у ВІЛ-інфікованих пацієнтів з різними типами перебігу інфекційного процесу. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32436<br>Установлена взаимосвязь распределения аллельных вариантов генов IL-4, IL-10, TNF-α у ВИЧ-инфицированных пациентов с различными типами течения инфекционного процесса. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/32436<br>It was found the correlation distribution of allelic variants of IL-4, IL-10

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Wang, Allen Ping-Lun. "The effect of hypoxia on the production of interleukin-10 (IL-10) in human mononuclear cells." Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/10228.

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Macrophages play an important role in both innate and adaptive immunity by engulfing intruding pathogens and damaged or infected cells, antigen presentation, and by secretion of immune mediators. Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine mainly produced by macrophages in response to cell activation, which serves to suppress immune reactions and inflammation. Hypoxia refers to oxygen deprivation. It is a common condition found in pathological tissues. The relationship between hypoxia and the production of IL-10 by macrophage is not yet thoroughly understood. In previous unpu

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Піддубна, Анна Іванівна, Анна Ивановна Поддубная та Anna Ivanivna Piddubna. "Поліморфізм гену IL-10 (-592C/А) у ВІЛ-інфікованих осіб". Thesis, Запорізький державний медичний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/31891.

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Наведені дані щодо розподілу алельних варіантів поліморфізм гену IL-10 (-592C/А) у ВІЛ-інфікованих українців При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/31891<br>Приведенные данные по распределению аллельных вариантов полиморфизм гена IL-10 (-592C/А) у ВИЧ-инфицированных украинцев При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/31891<br>The data of the distribution of allelic variants IL-10 (-592C/A) gene polymorphismin HIV-positive Ukrainian was presented When you are citing the document, use the follo

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Maynard, Craig Lueland. "IL-10-competent regulatory T cells development, phenotype and function /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2009r/maynard.pdf.

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Dokka, Sujatha. "IL-10 gene therapy for the treatment of pulmonary inflammation." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1421.

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Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 132 p. : ill. (some col.) Vita. Includes abstract. Includes bibliographical references.

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De, Simone Marco <1975&gt. "Molecular characterization of human CD4+ IL-10-producing regulatory cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6520/1/De_Simone_Marco_tesi.pdf.

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Previous studies in the group led to the identification of CD4+FOXP3- cells with regulatory functions in human blood that coproduce IL-10 and IFN-gamma. These cells do not belong to the Treg cell lineage since they are Foxp3- but they show some similarities with Th1 cells since they express CCR5, T-bet and produce high levels of IFN-gamma. Thus, they share relevant characteristics with both T regulatory type I cells (Tr1) and Th1 cells and we called them Th1-10 cells. In this study we presented a molecular characterization of Th1-10 cells that includes a gene expression and a microRNA profili

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De, Simone Marco <1975&gt. "Molecular characterization of human CD4+ IL-10-producing regulatory cells." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6520/.

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Previous studies in the group led to the identification of CD4+FOXP3- cells with regulatory functions in human blood that coproduce IL-10 and IFN-gamma. These cells do not belong to the Treg cell lineage since they are Foxp3- but they show some similarities with Th1 cells since they express CCR5, T-bet and produce high levels of IFN-gamma. Thus, they share relevant characteristics with both T regulatory type I cells (Tr1) and Th1 cells and we called them Th1-10 cells. In this study we presented a molecular characterization of Th1-10 cells that includes a gene expression and a microRNA profili

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Specht, Sabine. "Antagonism between IL-4 and IL-10 in colitis and a helminth infection in Mus musculus." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975502085.

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SANTOS, Raphaela Silva Leandro. "Avaliação da expressão de CD4, CD25, IL-10, IL-17 E FOXP 3 em cistos radiculares." Universidade Federal de Pernambuco, 2015. https://repositorio.ufpe.br/handle/123456789/25390.

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Submitted by Pedro Barros (pedro.silvabarros@ufpe.br) on 2018-08-02T20:16:51Z No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Raphaela Silva Leandro Santos.pdf: 2858553 bytes, checksum: fed89296295c51fb6999d3c552b880f5 (MD5)<br>Approved for entry into archive by Alice Araujo (alice.caraujo@ufpe.br) on 2018-08-03T21:59:14Z (GMT) No. of bitstreams: 2 license_rdf: 811 bytes, checksum: e39d27027a6cc9cb039ad269a5db8e34 (MD5) TESE Raphaela Silva Leandro Santos.pdf: 2858553 bytes, checksum: fed89296295c51fb6999d3c552b880f5 (MD5)<br>Made available in

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Oliveira, Walker Nonato Ferreira. "Regulação da resposta inflamatória na leishmaniose tegumentar: papel de il-10, tgf-β e il-27". reponame:Repositório Institucional da UFBA, 2013. http://www.repositorio.ufba.br/ri/handle/ri/12178.

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Submitted by Hiolanda Rêgo (hiolandar@gmail.com) on 2013-07-12T17:10:38Z No. of bitstreams: 1 Dissertação_ICS_Walker Oliveira.pdf: 646440 bytes, checksum: 715267f8e674a7d1a347adde1fef2b75 (MD5)<br>Made available in DSpace on 2013-07-12T17:10:38Z (GMT). No. of bitstreams: 1 Dissertação_ICS_Walker Oliveira.pdf: 646440 bytes, checksum: 715267f8e674a7d1a347adde1fef2b75 (MD5)<br>NIH Grant; CAPES<br>Introdução: A forte resposta do tipo Th1, com produção exagerada de IFN- e TNF-α, observada na leishmaniose tegumentar humana causada por Leishmania braziliensis está associada com a destruição tecidu

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Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-215877.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin

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Ruiz-Gómez, Gloria, John C. Hawkins, Jenny Philipp, et al. "Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics." Public Library of Science, 2016. https://tud.qucosa.de/id/qucosa%3A30052.

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Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the basic strategy of translating continuous binding epitopes into mimetic scaffolds cannot be applied, and other innovative approaches are therefore required. We present a structure-based rational approach involving the use of a regular expression syntax inspired in the well established PROSITE to defin

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34

Konarski, Yulia. "SHP-1/ Src Complex is a Master Regulator of the IL-12/IL-23 pro- and IL-10/IL-27 Anti-inflammatory Axis in TLR4-activated Signaling Pathways in Human Monocytes and Macrophages." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/25999.

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Although the etiology surrounding many autoimmune diseases remains unknown, the underlying characteristic of many of these diseases is a disruption in the balance of pro- and anti- inflammatory cytokines It is well established that the dysregulation of the IL-12 family of cytokines, an increase in IL-12/IL-23 and a decrease in IL-27 production has been implicated in these conditions. We used ELISA, RT-PCR, Immunofluorescence and Western immunoblotting in conjunction with pharmalogical inhibitors and siRNA to demonstrate the role of SHP-1/Src in the regulation of IL-12, IL-23, IL-27 and IL-10 i

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35

Saunders, Ana CecÃlia de Brito. "Polimorfismo e concentraÃÃo sÃrica da interleucina-10 em hansenÃase." Universidade Federal do CearÃ, 2010. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5271.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A hansenÃase continua sendo um problema de saÃde mundial, sendo o Brasil o segundo paÃs em maior em nÃmero de casos novos. No CearÃ a doenÃa Ã considerada endÃmica e em 2009 foram diagnosticados 1.952 casos novos, alcanÃando um coeficiente de detecÃÃo geral de 22,8/100.00 habitantes. A doenÃa Ã causada pelo M. leprae, manifesta-se atravÃs de sinais e sintomas dermatoneurolÃgicos e Ã transmitida de pessoa a pessoa atravÃs do convÃvio de indivÃduos suscetÃveis com doentes bacilÃferos sem tratamento. A interaÃÃo do M. leprae com os

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36

Walter, Johanna-Julia. "Der Einfluss von IL-10 auf die allergeninduzierte IL-4- und IL-13-Freisetzung aus basophilen Granulozyten von Patienten mit Wespengiftallergie." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-109346.

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37

Hata, Hiroshi. "Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice". Kyoto University, 2005. http://hdl.handle.net/2433/145302.

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38

Bigot, Jérémy. "Caractérisation fonctionnelle et phénotypique de lymphocytes B transitionnels CD24hi CD38hi associés à un phénotype régulateur chez des patients transplantés rénaux traités par Belatacept." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0071/document.

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A l’instar des lymphocytes T régulateurs, l’étude de populations lymphocytaires B au potentiel immunosuppresseur a émergé ces dernières années. La capacité immunosuppressive des lymphocytes B régulateurs CD24hi CD38hi passant notamment par leur capacité à exprimer l’IL-10 a été mise en évidence dans plusieurs pathologies notamment chez les patients atteints de maladies auto-immunes. En transplantation rénale, le rôle de ces cellules dans la tolérance du greffon a également été suggéré. Néanmoins, la caractérisation de ces cellules semble très controversée et complexe. En effet à ce jour, il n’

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39

Oei, Ju Lee Women's &amp Children's Health Faculty of Medicine UNSW. "Inflammatory imbalance in the development of bronchopulmonary dysplasia." Awarded by:University of New South Wales. Women's and Children's Health, 2007. http://handle.unsw.edu.au/1959.4/32504.

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Abstract Introduction: Current evidence suggests that the lungs of infants with the debilitating disorder, bronchopulmonary dysplasia (BPD), react to the challenges of extra-uterine adaptation with inappropriately aggressive inflammation. The reasons for this are not entirely clear and this study hypothesizes that a deficiency of interleukin (IL)-10, a potent anti-inflammatory mediator, leads to the functional and architectural changes characteristic of BPD. Aim: To characterize the behaviour of IL-10 and neutrophil apoptosis in the tracheal fluids (TF) of infants at risk of developing BPD.

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40

Smallie, Timothy Ian. "IL-10 mediated control of TNF gene regulation in human macrophages." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526398.

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41

Ryanna, Kimuli Barbara Wasonga. "Pharmacological induction of IL-10 regulatory cells in allergy and asthma." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/pharmacological-induction-of-il10-regulatory-cells-in-allergy-and-asthma(d01c2632-e10a-4b6d-91f8-966c004b6a77).html.

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Allergic and asthmatic disease is highly prevalent in the UK, however current treatments such as steroids, although effective in many individuals, only relieve disease symptoms, and do not provide long-lasting relief. Allergen immunotherapy can provide long-term alleviation of disease symptoms however is only effective in a proportion of patients, carries significant risk of adverse side effects and needs to be given over a prolonged period of time, often several years, for maximal efficacy. Allergic disease is associated not only with a type 2 adaptive immune response, but also impairment of

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42

Monteiro, Gl?ria Regina de G?is. "IL-10 na patog?nese da infec??o por Leishmania infantum." Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13316.

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Made available in DSpace on 2014-12-17T14:13:49Z (GMT). No. of bitstreams: 1 GloriaRGM_ TESE.pdf: 1372694 bytes, checksum: 5d2a22de8c374313099583a70edbaca6 (MD5) Previous issue date: 2013-05-10<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Leishmaniose visceral (LV) ? uma doen?a, potencialmente, fatal cujo agente etiol?gico nas Am?ricas ? a esp?cie Leishmania infantum. No Brasil, a LV era uma doen?a predominantemente rural at? os anos 80, quando epidemias passaram a ocorrer nas grandes cidades, devido ? migra??o da popula??o para periferia dos centros urbanos, especialm

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Нікітіна, О. Є., Н. М. Настрадіна, Н. В. Муріна та І. М. Стасій. "Стан продукції інтерферону-γ та інтерлейкінів IL-4 І IL-10 у хворих папіломавірусною інфекцією шийки матки". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32270.

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Імунна відповідь організму на вірус папіломи людини (ВПЛ) включає цілий ряд факторів захисту організму від патогенної дії ВПЛ. Це - синтез імуноглобулінів, комплементу, лізоциму, активність імунних клітин, розташованих в слизовій оболонці та регіонарних лімфатичних вузлах, продукція епітеліальними клітинами імунорегуляторних цитокінів, в тому числі й інтерферонів. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32270

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44

Azab, Belal. "Approaches for Enhancing Therapeutic Efficacy of a Novel IL-10 Gene Family Member: MDA-7/IL-24." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/266.

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Melanoma differentiation associated gene-7 (mda-7) was discovered in the Fisher laboratory by subtraction hybridization of temporally spaced subtracted cDNA libraries prepared from terminally differentiated human melanoma cells treated with human fibroblast interferon (IFN-β) and the protein kinase C activator mezerein (MEZ), an approach called ‘differentiation induction subtraction hybridization’ (DISH). mda-7 is located in human chromosome 1q32–33 and based on sequence homology, chromosomal localization, and its functional properties, the mda-7 gene is now classified as a member of the IL-10

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45

Lima, Luana Nepomuceno Gondim Costa. "Estudo do polimorfismo dos genes das citocinas TNFα, IFNγ, TGFβ, IL-6, E IL-10 em hanseníase". reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/1904.

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LIMA, Luana Nepomuceno Gondim Costa. Estudo do polimorfismo do genes das citocinas TNFa, IFNy, TGFß, IL-6, E IL-10 em hanseníase . 2009. 164 f. Dissertação (Mestrado em Microbiologia Médica) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-01-05T12:56:35Z No. of bitstreams: 1 2009_dis_lngclima.pdf: 1702836 bytes, checksum: 54a1aa9b42b5683d9013d146e3e741d1 (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-02-02T16:26:17Z (GMT) No. of bitstreams: 1 2009_dis_lngclima.pd

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Pilon, Riccardo <1989&gt. "Il performance management nella pubblica amministrazione: percorsi di innovazione e il caso U.L.S.S. n. 10 "Veneto Orientale"." Master's Degree Thesis, Università Ca' Foscari Venezia, 2015. http://hdl.handle.net/10579/6757.

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La valutazione della performance, in particolare quella legata alle persone, è diventata nel corso del tempo un elemento strategico di primo piano nella gestione delle aziende. Le informazioni estrapolate dal processo di valutazione possono portare a decisioni fondamentali non solo per lo sviluppo organizzativo, ma soprattutto per individuare i punti di forza e di debolezza delle risorse umane. Nel contesto pubblico la performance ha assunto negli anni recenti un’importanza ancora più elevata, grazie alle nuove correnti di public management che impongono una forte riorganizzazione della spesa

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47

Rivas, Mayorga Catalina Andrea. "Niveles de IL-6, IL-10, IL-17, IL21 y TGF-B1 asociados a la periodontitis crónica :Financiado por proyecto FONDECYT 1090046." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/133346.

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Trabajo de Investigación Requisito para optar al Título de Cirujano Dentista<br>Autor no autoriza el acceso a texto completo de su documento<br>INTRODUCCIÓN: La periodontitis crónica es una enfermedad de origen infeccioso caracterizada por la interacción entre bacterias patógenas y mecanismos de defensa del hospedero. Se ha demostrado que las citoquinas IL-6, IL-21, y TGF-β participan en la diferenciación de células Th17, mientras que TGF-β , en ausencia de las otras mencionadas, induce la diferenciación de células Treg. Esto indica una fuerte relación entre células Th17 y Treg: si se

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48

Howes, A. F. "The regulation of interleukin-10 and interleukin-12 in macrophages : investigating the differential regulation of IL-10 and IL-12 in C57BL/6 and BALB/c mice." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1409974/.

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Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12) is a proinflammatory cytokine important for the differentiation of T helper 1 (Th1) cells which produce IFN-γ to activate macrophages and eradicate intracellular pathogens. In contrast, interleukin-10 (IL-10) is an immunosuppressive cytokine that minimises immune-driven host pathology, but can also lead to defective pathogen clearance. The regulation of IL-10 and IL-12 is therefore of interest due to their central roles in the orchestration of an eff

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49

Nicioli, Cristiane. "Efeito do treinamento de musculação em circuito sobre a aptidão cardiorrespiratória e citocinas plasmáticas IL-6, IL-8, IL-10, TNF, IL-1β e IL-12p70 em mulheres saudáveis." Universidade Federal de São Carlos, 2008. https://repositorio.ufscar.br/handle/ufscar/1293.

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Made available in DSpace on 2016-06-02T19:22:48Z (GMT). No. of bitstreams: 1 1772.pdf: 1053575 bytes, checksum: 40cbf214e905c258d1b9f3577e530886 (MD5) Previous issue date: 2008-03-28<br>Universidade Federal de Sao Carlos<br>There are evidences demonstrating that long-term aerobic exercises boost the plasmatic cytokines concentrations. However, there are few researches that deal with that relation in short-term and high intensity ones. This study aims at verifying the effects of strength training in circuit over the cardiorespiratory competence response and also over the plasmatic cytokines I

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50

Mattos, Marlon Fraga. "Níveis séricos e polimorfismos genéticos das interleucinas IL-6 E IL-10 em indivíduos com síndrome de down." Faculdade de Medicina de São José do Rio Preto, 2017. http://hdl.handle.net/tede/433.

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Submitted by Suzana Dias (suzana.dias@famerp.br) on 2018-10-26T18:02:09Z No. of bitstreams: 1 MarlonFragaMattos_dissert.pdf: 1719909 bytes, checksum: 70d153012a84a6566276733a0ea859da (MD5)<br>Made available in DSpace on 2018-10-26T18:02:09Z (GMT). No. of bitstreams: 1 MarlonFragaMattos_dissert.pdf: 1719909 bytes, checksum: 70d153012a84a6566276733a0ea859da (MD5) Previous issue date: 2017-09-30<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Down syndrome (DS) is the most frequent human chromosomopathy with approximate incidence of the 1 to 850 live births, nearly 90-

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