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Articoli di riviste sul tema "Immunoglobulin A"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Hasegawa, Haruki. "Aggregates, Crystals, Gels, and Amyloids: Intracellular and Extracellular Phenotypes at the Crossroads of Immunoglobulin Physicochemical Property and Cell Physiology." International Journal of Cell Biology 2013 (2013): 1–22. http://dx.doi.org/10.1155/2013/604867.

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Recombinant immunoglobulins comprise an important class of human therapeutics. Although specific immunoglobulins can be purposefully raised against desired antigen targets by various methods, identifying an immunoglobulin clone that simultaneously possesses potent therapeutic activities and desirable manufacturing-related attributes often turns out to be challenging. The variable domains of individual immunoglobulins primarily define the unique antigen specificities and binding affinities inherent to each clone. The primary sequence of the variable domains also specifies the unique physicochem

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2

Gong, Yuxin, Bo Liao, Dejun Peng, and Quan Zou. "Accurate Prediction and Key Feature Recognition of Immunoglobulin." Applied Sciences 11, no. 15 (2021): 6894. http://dx.doi.org/10.3390/app11156894.

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Immunoglobulin, which is also called an antibody, is a type of serum protein produced by B cells that can specifically bind to the corresponding antigen. Immunoglobulin is closely related to many diseases and plays a key role in medical and biological circles. Therefore, the use of effective methods to improve the accuracy of immunoglobulin classification is of great significance for disease research. In this paper, the CC–PSSM and monoTriKGap methods were selected to extract the immunoglobulin features, MRMD1.0 and MRMD2.0 were used to reduce the feature dimension, and the effect of discrimin

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3

Tsavaris, N., D. Tsigalacis, C. Kosmas, et al. "Preliminary Evaluation of the Potential Prognostic Value of Serum Levels of Immunoglobulins (IgA, IgM, IgG, IgE) in Patients with Gastric Cancer." International Journal of Biological Markers 13, no. 2 (1998): 87–91. http://dx.doi.org/10.1177/172460089801300204.

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Sixty patients with advanced gastric carcinoma who refused to receive cytotoxic chemotherapy were examined for serum immunoglobulin levels (IgG, IgM, IgA, IgE). Three samples were obtained every two months thereafter. The group of patients who had above-normal values of one or more of the examined immunoglobulins had a longer survival than the other (p<0.024). Immunoglobulin values were independent of the Helicobacter pylori antibody titer and of acute phase reactants. It is concluded that survival potentially correlates with serum immunoglobulin levels. Further studies including larger num

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4

Puspitasari, Heni, Yuliana Praptiwi, and Lucia Suwanti. "Production and Characterization of Immunoglobuline Yolk as anti antigen membrane Toxoplasma gondii." Indonesian Journal of Tropical and Infectious Disease 6, no. 2 (2016): 29. http://dx.doi.org/10.20473/ijtid.v6i2.1365.

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Toxoplasma gondii is an obligate parasite intracellular which can infected human and other mammalian. Immunoglobulin Y technology offers several advantages better than antibody production in mammals. This research was aimed to get immunoglobulin Y from egg yolk, to prove that antibody against membrane T. gondii antigen can produced from immunoglobulin Y and to know the characterization of immunoglobuline Y according to molecular weight by SDS PAGE and reactivation of antibody antigen by Western Blott. This research devided from many step : passase tachyzoites T. gondii into mice by peritoneal

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5

Srikumaran, S., E. A. Kluever, D. V. Onisk, and K. Hariharan. "Quantitation of bovine immunoglobulins in culture fluids by use of sandwich radioimmunoassay with monoclonal antibodies." American Journal of Veterinary Research 52, no. 2 (1991): 243–46. http://dx.doi.org/10.2460/ajvr.1991.52.02.243.

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SUMMARY Bovine immunoglobulin isotype-specific murine monoclonal antibodies were used in sandwich radioimmunoassays to detect and quantitate bovine IgG1, IgG2, IgM, and IgA in culture fluids. The concentrations of bovine immunoglobulins in unknown samples were extrapolated from standard curves generated with bovine monoclonal immunoglobulins. The lowest detection limits for the bovine immunoglobulin isotypes ranged from 65 to 270 ng/ml.

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6

Okamoto, Yasuyuki, Noboru Hamada, Toshimichi Fujisawa, et al. "Why no simple relationship between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function in autoimmune thyroid disease?" Acta Endocrinologica 124, no. 4 (1991): 442–48. http://dx.doi.org/10.1530/acta.0.1240442.

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Abstract. We have reported that some anti-thyroid peroxidase antibodies inhibit the activity of thyroid peroxidase in vitro. These thyroid peroxidase activity-inhibiting immunoglobulins seem to inhibit thyroid function in some patients, but the relationship between thyroid peroxidase activity-inhibiting immunoglobulins and thyroid function is not simple. We designed this study to explore this lack of a simple relationship. We stained immunoglobulin G deposits by immunofluorescence staining or the peroxidase-antiperoxidase method, and stained endogenous thyroid peroxidase activity by enzyme his

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7

Santos, José Augusto Rodrigues, Ricardo J. Fernandes, and Rodrigo Zacca. "Multi-Micronutrient Supplementation and Immunoglobulin Response in Well-Fed Firefighters." Sports Medicine International Open 05, no. 01 (2020): E1—E7. http://dx.doi.org/10.1055/a-1296-1486.

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AbstractIntensive physical training programs can affect the immune system. This study aims to verify the multi-micronutrient supplementation effects on serum immunoglobulins levels prior to and after a five-week physical training program. Twenty-four male recruit firefighters were randomly allocated into supplemented (with Prisfar Ever-Fit Plus over 35 consecutive days) and placebo groups (n=12 each). Serum immunoglobulins G, A, and M were assessed. Supplementation effect was detected for immunoglobulin G (eta-squared, η2: 0.09; p=0.035; power: 0.56), A (η2: 0.24; p=0.001; power: 0.95), and M

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8

Schweitzer, P. A., S. E. Taylor, and L. D. Shultz. "Synthesis of abnormal immunoglobulins by hybridomas from autoimmune "viable motheaten" mutant mice." Journal of Cell Biology 114, no. 1 (1991): 35–43. http://dx.doi.org/10.1083/jcb.114.1.35.

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Secretory defects in abnormal plasma cells, called Mott cells, that appear in lymphoid tissues of spontaneously autoimmune, "viable motheaten" (mev/mev) mice lead to deposition of immunoglobulin in RER-bound vesicles. Such vesicles have been termed Russel bodies. Cells with Russel bodies can also be observed rarely in normal animals, usually as a result of extreme antigenic loads or pathologic states. To understand why these abnormal cells appear commonly in mev/mev mice, we have established a panel of hybridomas that contain Russell bodies. Using immunochemical analysis and immunoelectron mic

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9

Pohanka, M. "Evaluation of Immunoglobulin Production during Tularaemia Infection in BALB/c Mouse Model." Acta Veterinaria Brno 76, no. 4 (2007): 579–84. http://dx.doi.org/10.2754/avb200776040579.

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The chromatographic technique was used for assay of time-dependent content of antibodies in mice BALB/c infected by tularaemia. The assay was consequently performed on two types of chromatographic sorbents. The first was commercial CBindTM specific for serum immunoglobulins IgM, IgG and IgA. The second was originally prepared sorbent including protein G covalently bound on EnzacrylRAH particles. This sorbent has specificity for immunoglobulin IgG and its subclasses only. Finally, mass concentration of immunoglobulins in serum was determined. Two curves expressing time behavior of immunoglobuli

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10

Lock, R. J., and D. J. Unsworth. "Immunoglobulins and immunoglobulin subclasses in the elderly." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 2 (2003): 143–48. http://dx.doi.org/10.1258/000456303763046067.

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Background: Published data imply that adult concentrations are achieved for all Ig isotypes and plateau by 15--18 years of age. Recent data, however, suggest that these results are not applicable in the elderly. There are no equivalent data for IgG subclasses. We present reference range data for an elderly UK patient population, for IgG, IgA, IgM and IgG subclasses. Methods: Serum immunoglobulins were reviewed on samples from 1146 patients > 60 years of age and 925 patients aged 18--60 years. Serum IgG subclasses were reviewed on samples from 498 patients >60 years and 484 patients aged

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11

Walther, Stefanie, Tamara V. Rusitzka, Ulrike S. Diesterbeck, and Claus-Peter Czerny. "Equine immunoglobulins and organization of immunoglobulin genes." Developmental & Comparative Immunology 53, no. 2 (2015): 303–19. http://dx.doi.org/10.1016/j.dci.2015.07.017.

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12

Butler, J. E., and W. R. Brown. "The immunoglobulins and immunoglobulin genes of swine." Veterinary Immunology and Immunopathology 43, no. 1-3 (1994): 5–12. http://dx.doi.org/10.1016/0165-2427(94)90114-7.

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13

Wagner, Bettina. "Immunoglobulins and immunoglobulin genes of the horse." Developmental & Comparative Immunology 30, no. 1-2 (2006): 155–64. http://dx.doi.org/10.1016/j.dci.2005.06.008.

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14

Sokołowska, J., J. Micuń, K. Zabielska, E. Malicka, and R. Lechowski. "Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomas." Polish Journal of Veterinary Sciences 13, no. 4 (2010): 623–28. http://dx.doi.org/10.2478/v10181-010-0004-5.

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Immunohistochemical study of expression of immunoglobulins in canine B-cell lymphomasNineteen canine lymphomas were included in this study. Tumors were classified according to the updated Kiel classification adapted for canine lymphomas by Fournel-Fleury et al. Immunoglobulin light chains (κ and λ) and IgM and IgG expression were determined by immunohistochemical method. In all examined cases neoplastic cells were positive for one of the immunoglobulin light chains. Expression of λ light chains and κ light chains was observed in 18/19 and 1/19 tumors, respectively. In the majority of neoplasti

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15

Akhmetzyanov, V. A., O. V. Chibiskova, and E. F. Kolesanova. "Selection of the Most Efficient Protocol for the Immunoglobulin Y Extraction from Hen Egg Yolk." Biomedical Chemistry: Research and Methods 5, no. 4 (2022): e00179. http://dx.doi.org/10.18097/bmcrm00179.

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Four protocols of immunoglobulin Y extraction and purification from hen egg yolk were compared and the optimal one was chosen from the viewpoint of the purity and yield of the final protein preparation. The following protocols were tested: 1) three-step treatment of the yolk substance with caprylic acid; 2) delipidation with dextran-sulfate followed by sodium sulfate fractionation; 3) removal of lipids via diluting by acidified water followed by sodium sulfate fractionation and 4) purification of immunoglobulins with the use of egg yolk freezing-thawing. Protein yields were assessed as amounts

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16

Gasperi, Christiane, Till F. M. Andlauer, Ana Keating, et al. "Genetic determinants of the humoral immune response in MS." Neurology - Neuroimmunology Neuroinflammation 7, no. 5 (2020): e827. http://dx.doi.org/10.1212/nxi.0000000000000827.

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ObjectiveIn this observational study, we investigated the impact of genetic factors at the immunoglobulin heavy chain constant locus on chromosome 14 and the major histocompatibility complex region on intrathecal immunoglobulin G, A, and M levels as well as on B cells and plasmablasts in the CSF and blood of patients with multiple sclerosis (MS).MethodsUsing regression analyses, we tested genetic variants on chromosome 14 and imputed human leukocyte antigen (HLA) alleles for associations with intrathecal immunoglobulins in 1,279 patients with MS or clinically isolated syndrome and with blood a

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17

Спицын, А. Н., Д. В. Уткин, М. Н. Киреев та ін. "Спектрофотометрическая характеристика конъюгатов иммуноглобулинов для диагностики возбудителей особо опасных инфекций". Журнал технической физики 128, № 3 (2020): 430. http://dx.doi.org/10.21883/os.2020.03.49071.76-19.

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The possibility of using spectrophotometric analysis to characterize fluorescent immunoglobulins as a control method was considered. A comparative analysis of the optical properties of fluorescent immunoglobulin preparations and their constituent components - immunoglobulins, fluorochrome was carried out. The results suggest that the proposed methodological approach of optical detection of labeled immunoglobulin molecules is promising for controlling the preparation of conjugates used in the formulation of immunological reactions to identify specific antigens of pathogens of particularly dange

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18

Wiese, Rick, Aliya Gessling, and David Hayes. "Multiplex immunoglobulin isotyping assays for human, mouse or rat serum samples (65.25)." Journal of Immunology 186, no. 1_Supplement (2011): 65.25. http://dx.doi.org/10.4049/jimmunol.186.supp.65.25.

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Abstract The determination of serum immunoglobulin isotype concentrations is an important indicator of immunological health. We have constructed several multiplex isotyping assays on the Luminex® assay platform. These assays allow for the analysis of human, mouse and rat serum, tissue culture or body fluid samples. The human isotyping assay enables the quantification of immunoglobulins A, M, G1, G2, G3 and G4 in a single assay well. While the mouse isotyping assay cover immunoglobulins A, M, G1, G2A, G2B, and G3, and the rat isotyping immunoglobulins A, E, M, G1, G2A, G2B, G2C. Since the conce

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19

Zubavichene, N. M., V. V. Zolin, and E. A. Stavsky. "Liposomal and Suspension Forms of Immunoglobulins Against Ebola Fever as the New Medical Preparations." Problems of Particularly Dangerous Infections, no. 4(110) (August 20, 2011): 57–60. http://dx.doi.org/10.21055/0370-1069-2011-4(110)-57-60.

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Presented are the results of investigation of therapeutic effectiveness of liposomal and suspension forms of immunoglobulins, prepared on the basis of 10 % goat immunoglobulin against Ebola fever. The most pronounced therapeutic and preventive effect on guinea pigs with experimental Ebola fever was achieved by double administration of suspended immunoglobulin against Ebola fever. The incubation period increased twofold, 37,5 % of infected animals survived. The results achieved are perspective for further development of new immunoglobulin preparations on the basis of liposomes and nanoemulsions

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20

Moskalets, O. V. "Selective Immunoglobulin A Deficiency Associated with Immunoglobulin G4 Deficiency in Adult Patient." Doctor.Ru 23, no. 1 (2024): 82–85. http://dx.doi.org/10.31550/1727-2378-2024-23-1-82-85.

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Aim. To demonstrate the possibility of developing primary immunodeficiency with impaired antibody synthesis in an adult patient and discuss the algorithm for laboratory diagnostics and treatment tacticsto demonstrate the possibility of developing primar hypoimmunoglobulinemia after a course of imunosupressive therapy. Key points. Primary immunodeficiencies are a group of diseases associated with monogenic mutations. They do not have a typical clinical picture. A clinical observation is presented, when a selective deficiency of immunoglobulin A in combination with a selective deficiency of the

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21

Kim, Hwan Keun, Fabiana Falugi, Dominique Missiakas, and Olaf Schneewind. "Expression of two immunoglobulin binding proteins is necessary for S. aureus to avoid host mediated innate and adaptive immune systems (P3138)." Journal of Immunology 190, no. 1_Supplement (2013): 186.16. http://dx.doi.org/10.4049/jimmunol.190.supp.186.16.

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Abstract Human or animal infections with S. aureus do not elicit protective immunity against staphylococcal diseases. Staphylococci are notorious to deploy a wide spectrum of strategies to avoid host immune system. Previous work revealed that both innate and adaptive immune systems are hampered by the expression of two immunoglobulin binding proteins; staphylococcal protein A (SpA) and staphylococcal binder of immunoglobulins (Sbi). Staphylococcal protein A, a molecule that associates with both Fc and Fab portions of immunoglobulins, is necessary 1) to neutralize the antibody mediated opsonoph

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22

Roth, Michael. "Is There a Regulatory Role of Immunoglobulins on Tissue Forming Cells Relevant in Chronic Inflammatory Lung Diseases?" Journal of Allergy 2011 (November 2, 2011): 1–9. http://dx.doi.org/10.1155/2011/721517.

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Epithelial cells, fibroblasts and smooth muscle cells together form and give structure to the airway wall. These three tissue forming cell types are structure giving elements and participate in the immune response to inhaled particles including allergens and dust. All three cell types actively contribute to the pathogenesis of chronic inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Tissue forming cells respond directly to allergens through activated immunoglobulins which then bind to their corresponding cell surface receptors. It was only recently re

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Pu, C., S. Sukhal, and S. Fakhran. "Humoral Immunity in Bronchiectasis: Finding Good’s Syndrome." Case Reports in Pulmonology 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/531731.

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We present a case of a 37-year-old man with a past history of a surgically removed thymoma, who presented with recurrent pulmonary infections and bronchiectasis. On further testing, he was found to have low total immunoglobulin levels, a constellation of findings known as Good’s syndrome. He responded well to immunoglobulin replacement, in addition to the usual treatments for bronchiectasis. We present this case to emphasize the association of bronchiectasis, low immunoglobulins, and thymomas and the role of immunoglobulin replacement as a treatment option.

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Almaghlouth, Ibrahim, Sindhu R. Johnson, Eleanor Pullenayegum, Dafna Gladman, and Murray Urowitz. "Immunoglobulin levels in systemic lupus erythematosus: A narrative review." Lupus 30, no. 6 (2021): 867–75. http://dx.doi.org/10.1177/09612033211004714.

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Immunoglobulins play a fundamental role in the protection of the human body against internal and external threats. They also contribute to the immune system homeostasis and maintenance of self-tolerance. Hypogammaglobulinemia is occasionally encountered in routine clinical practice by rheumatologists. Low levels of immunoglobulins can occur as primary or secondary issues and may predispose patients to various forms of infection. However, the impact of the low immunoglobulin level abnormality varies with the underlying condition. In this narrative review, we shed light on the overall types and

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Merkel, Glenn J., Charles L. Phelps та Roger W. Roeske. "Cell surface specific immunoglobulin inhibits α factor mediated morphogenesis in Saccharomyces cerevisiae". Canadian Journal of Microbiology 33, № 4 (1987): 331–35. http://dx.doi.org/10.1139/m87-056.

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Immunoglobulins raised from Saccharomyces cerevisiae a and α mating type cell envelope preparations inhibited α factor mediated morphogenesis of the a cell without inhibiting normal cell division. The Ig responsible for this inhibition was absorbed to both a and α whole cells and heat-killed cells, indicating that the immunoglobulin binding sites were exposed on the cell surface and not mating type specific. Additionally, α factor mediated cell cycle arrest was not affected by the immunoglobulin preparations, implying that the immunoglobulin was not preventing α factor from binding to its rece

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Markina, Yuliya V., Elena V. Gerasimova, Alexander M. Markin, et al. "Sialylated Immunoglobulins for the Treatment of Immuno-Inflammatory Diseases." International Journal of Molecular Sciences 21, no. 15 (2020): 5472. http://dx.doi.org/10.3390/ijms21155472.

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Immunoglobulins are the potent effector proteins of the humoral immune response. In the course of evolution, immunoglobulins have formed extremely diverse types of molecular structures with antigen-recognizing, antigen-binding, and effector functions embedded in a single molecule. Polysaccharide moiety of immunoglobulins plays the essential role in immunoglobulin functioning. There is growing evidence that the carbohydrate composition of immunoglobulin-linked glycans, and especially their terminal sialic acid residues, provide a key effect on the effector functions of immunoglobulins. Possibly

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Ahmann, Johanna, Julia Steinhoff-Wagner, and Wolfgang Büscher. "Determining Immunoglobulin Content of Bovine Colostrum and Factors Affecting the Outcome: A Review." Animals 11, no. 12 (2021): 3587. http://dx.doi.org/10.3390/ani11123587.

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The immunoglobulin concentration in bovine colostrum should be measured to ensure feeding with sufficient immunoglobulins (≥50 mg immunoglobulin G mL−1). Adequate feeding prevents diseases, promotes development, and has a positive influence on the adult animal. Indirect and direct measurement methods are available for this purpose. Direct measurement methods cannot be easily used in practice; therefore, farmers use indirect methods such as a colostrometer and a refractometer. Many factors influence the immunoglobulin concentration of colostrum; some of them have already been intensively resear

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Sedlinská, M., J. Krejčí, M. Vyskočil, and H. Kudláčková. "Postnatal Development of Blood Serum Concentrations of Immunoglobulin IgG, IgA and IgM Isotypes in Suckling Foal." Acta Veterinaria Brno 75, no. 2 (2006): 175–82. http://dx.doi.org/10.2754/avb200675020175.

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Postnatal changes in concentrations of immunoglobulin IgG, IgM and IgA isotypes from birth until the age of five months were monitored by the ELISA method. The experiment was performed in a group of 52 thoroughbred foals and their mothers. Among the investigated animals, failure of colostral immunity transfer was recorded in only four foals (7.7 percent). The concentrations of immunoglobulin IgG and IgA isotypes primarily decreased during the first weeks of life and then gradually increased until the end of the investigated period. The concentrations of immunoglobulin IgG isotype reached the v

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Myara, I., G. Quenum, M. Storogenko, D. Tenenhaus, R. Guillemain, and N. Moatti. "Monoclonal and oligoclonal gammopathies in heart-transplant recipients." Clinical Chemistry 37, no. 8 (1991): 1334–37. http://dx.doi.org/10.1093/clinchem/37.8.1334.

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Abstract Immunoglobulin abnormalities in serum from 76 heart-transplant recipients were examined by cellulose acetate and agarose gel electrophoresis. Monoclonal components were typed by immunofixation. IgG, IgA, and IgM and total kappa and lambda light chains were quantified by immunonephelometry. We confirm that both monoclonal and oligoclonal immunoglobulin banding are common in serum from these patients. Of the 149 serum samples examined, 21 (15%) had one monoclonal component and 53 (35%) had two or more. These monoclonal immunoglobulins were generally present at a low concentration and we

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Kouvalainen, K., and I. Moilanen. "Intrapair Similarity of Immunoglobulin Levels in Twins." Acta geneticae medicae et gemellologiae: twin research 36, no. 4 (1987): 509–15. http://dx.doi.org/10.1017/s0001566000006887.

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AbstractLevels of immunoglobulins IgG, IgA, IgM and IgE were determined in 8 MZ and 14 DZ twin pairs at the ages of 6-11 years, 12-17 years and 15-20 years. Intrapair similarity in immunoglobulin levels was found to be higher in the MZ than in the DZ twins, especially in the case of immunoglobulins IgA and IgM.

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Generalov, S. V., E. G. Abramova, Zh V. Matveeva, et al. "Cultural Antigen in the Technology for Anti-Rabies Immunoglobulin Obtainment from Equine Blood Serum." Problems of Particularly Dangerous Infections, no. 4(114) (August 20, 2012): 65–68. http://dx.doi.org/10.21055/0370-1069-2012-4-65-68.

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week after immunization (specific activity is identified using neutralization reaction on the model of white mice and dot-blot immunoassay). This level of activity is sufficient for the fractioning of immune serum and extraction of anti-rabies immunoglobulin. Physicochemical and biological properties of the anti-rabies immunoglobulin, obtained with the help of cultural antigen technique, meet the requirements stated in the normative documentation on anti-rabies immunoglobulins extracted from equine blood serum. Specific activity level of experimental batches of anti-rabies immunoglobulin, obta

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Mishalova, Е. Yu, E. V. Gordeev, V. N. Lebedev, S. A. Melnikov, S. A. Nimirskaya, and S. V. Borisevich. "Experimental Testing of a Size-Exclusion Chromatography Method Used for Evaluation of Molecular Parameters of Equine Anti-Ebola Immunoglobulin." BIOpreparations. Prevention, Diagnosis, Treatment 19, no. 4 (2019): 261–67. http://dx.doi.org/10.30895/2221-996x-2019-19-4-261-267.

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Haemorrhagic fever caused by the Ebola virus is a highly hazardous infectious disease with a mortality rate of 50– 90 %. Heterologous immunoglobulins with a high virus-neutralizing titer are an important element of the WHO-endorsed set of measures for emergency prevention and treatment of the disease. Specific activity of these products is largely determined by their fractional composition, and, in particular, by molecular mass distribution (MMD). The size-exclusion-high-performance liquid chromatography (SEC-HPLC) has traditionally been used for determination of the MMD of the target protein

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Conti, Francesca, Mattia Moratti, Lucia Leonardi, et al. "Anti-Inflammatory and Immunomodulatory Effect of High-Dose Immunoglobulins in Children: From Approved Indications to Off-Label Use." Cells 12, no. 19 (2023): 2417. http://dx.doi.org/10.3390/cells12192417.

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Background: The large-scale utilization of immunoglobulins in patients with inborn errors of immunity (IEIs) since 1952 prompted the discovery of their key role at high doses as immunomodulatory and anti-inflammatory therapy, in the treatment of IEI-related immune dysregulation disorders, according to labelled and off-label indications. Recent years have been dominated by a progressive imbalance between the gradual but constant increase in the use of immunoglobulins and their availability, exacerbated by the SARS-CoV-2 pandemic. Objectives: To provide pragmatic indications for a need-based app

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Jonic, Branko, and Milorad Mirilovic. "Contribution to knowledge of colostral immunoglobulin absorption in intensively bred calves." Veterinarski glasnik 61, no. 5-6 (2007): 291–99. http://dx.doi.org/10.2298/vetgl0706291j.

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A whole series of factors affect the degree of absorption of colostral immunolobulins. One of the most important factors is the time of feeding of newborn calves with colostrums in the first hours following birth. The objective of these investigations was to determine the effect of immunoglobulin concentration in colostrum on the process of immunoglobulin absorption during the first day of life of calves. A farm of Holstein-Friesian cows was selected for these investigations. The examinations covered 35 cows. For the examination of total immunoglobulin concentration, colostrum was taken two ho

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Goode, N. P., A. M. Davison, G. Gowland, and M. Shires. "Spontaneous glomerular immunoglobulin deposition in young Sprague-Dawley rats." Laboratory Animals 22, no. 4 (1988): 287–92. http://dx.doi.org/10.1258/002367788780746232.

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The frequency, age-onset and distribution of spontaneously deposited immunoglobulins (lgs) in glomeruli of Sprague-Dawley rats has been investigated. Groups of rats ( n=10) were examined at 4-7 day intervals from birth (presuckling) until 30 days of age. Findings were compared with circulating immunoglobulin concentrations in each age group. Immunoglobulins were undetectable in immature kidneys of newborn rats. However, as early as 5 days, scanty IgA and IgM deposits were observed predominantly in mesangial areas of mature glomeruli, corresponding to low circulating concentrations of these imm

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Di Mario, U., L. Crisa, E. Anastasi, et al. "Anti-goat immunoglobulin antibodies in diabetic children at diagnosis and follow-up: comparison with islet cell antibodies and other autoantibodies." Acta Endocrinologica 120, no. 3 (1989): 326–30. http://dx.doi.org/10.1530/acta.0.1200326.

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Abstract. The presence of antibodies reacting with human as well as animal immunoglobulins in sera from recent onset Type I diabetic patients has been recently demonstrated by some of our group. In the present study, the occurrence of these antibodies has been evaluated in sera from 19 Type I diabetic patients, at diagnosis and at follow-up within three years, and from 26 normal subjects, and has also been compared with the presence of islet cell antibodies and other organ-specific autoantibodies. A solid-phase radioimmunoassay has been used: serum was incubated in goat immunoglobulin-coated w

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Rodina, Y. A., I. N. Abramova, and A. Yu Shcherbina. "Subcutaneous immunoglobulin for treatment of patients with primary immunodeficiencies: review of the literature and personal experience." Russian Journal of Allergy 15, no. 2 (2018): 29–36. http://dx.doi.org/10.36691/rja160.

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Abstract (sommario):

Substitution with normal human immunoglobulin is a golden standard of primary immunodeficiencies therapy. Subcutaneous immunoglobulins, especially delivered via «rpid push» method are gaining popularity among patients and treating physician since at home infusions allow to reduce treatment costs and increase patients’ quality of life. Here we report first Russian experience of subcutaneous infusion of Gamunex®-C immunoglobulin, in four patients with primary immunodeficiencies, performed by their parents via «rapid push» method at home. No systemic reactions have been reported, Gamunex®-C treat

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Immler, Manuela, Kathrin Büttner, Tanja Gärtner, Axel Wehrend, and Karsten Donat. "Maternal Impact on Serum Immunoglobulin and Total Protein Concentration in Dairy Calves." Animals 12, no. 6 (2022): 755. http://dx.doi.org/10.3390/ani12060755.

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For dairy calves, sufficient supply with high-quality maternal colostrum is crucial to achieve adequate passive transfer of immunoglobulins. This observational cross-sectional study aimed to determine the influence of the prepartum metabolic status of dams on the serum immunoglobulin and total protein concentrations of their dairy calves, taking other relevant management factors into account. A total of 551 cows and their calves from 124 German dairy farms were included. Blood and urine samples of the cows were sampled 1 to 3 weeks before the expected calving date. Two generalized linear mixed

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Dimitroglou, Margarita, Rozeta Sokou, Nicoletta Iacovidou, et al. "Anti-SARS-CoV-2 Immunoglobulins in Human Milk after Coronavirus Disease or Vaccination—Time Frame and Duration of Detection in Human Milk and Factors That Affect Their Titers: A Systematic Review." Nutrients 15, no. 8 (2023): 1905. http://dx.doi.org/10.3390/nu15081905.

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Abstract (sommario):

Human milk (HM) of mothers infected with or vaccinated against SARS-CoV-2 contains specific immunoglobulins, which may protect their offspring against infection or severe disease. The time frame and duration after infection or vaccination, during which these immunoglobulins are detected in HM, as well as the major factors that influence their levels, have not been fully elucidated. This systematic review aimed to collect the existing literature and describe the immune response, specifically regarding the immunoglobulins in HM after COVID-19 disease or vaccination in non-immune women. We conduc

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Kosolapova, Irina V., Evgenij V. Dorohov, and Roman V. Lesnikov. "Dynamic assessment of the enzyme immunoassay composition of the oral fluid in children with physiological occlusion and anomalies of the dentition." Kazan medical journal 103, no. 1 (2022): 63–68. http://dx.doi.org/10.17816/kmj2022-63.

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Abstract (sommario):

Background. Understanding the dynamics of changes in the immunoenzyme composition of the oral fluid at various stages of treatment will allow the doctor to correctly draw up a treatment plan, predict its timing, and prevent the development of complications. Aim. Dynamic assessment of the enzyme immunoassay composition of the oral fluid in children with physiological occlusion and anomalies of the dentoalveolar system. Material and methods. The study groups consisted of 125 children aged 612 years with anomalies of the dentoalveolar system receiving treatment with plate and mouth gu

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Yéléhé-Okouma, Mélissa, Catherine Malaplate, Nadine Petitpain, et al. "IMMUNOGLOBULIN PREPARATIONS CAN MISLEAD CLINICAL DECISION-MAKING IN FOLLOW-UP OF DIFFERENTIATED THYROID CANCER." Endocrine Practice 26, no. 9 (2020): 1031–38. http://dx.doi.org/10.4158/ep-2020-0053.

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Abstract (sommario):

Objective: Intravenous and subcutaneous immunoglobulins are commonly used for immune substitution or as immune modulators in a variety of inflammatory and autoimmune disorders. Exogenous thyroid-specific thyroglobulin (Tg) antibodies present in the donor plasma may interfere with the interpretation of measurements of Tg autoantibodies (Tg-Abs) in the recipient’s plasma and potentially trigger an immune response in the recipient’s immune cells. Levels of antibodies causing bioassay interferences or those leading to clinically relevant changes in patient outcomes are not known. Tg is used as a b

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Chitose, S., T. Sakazaki, T. Ono, T. Kurita, H. Mihashi, and T. Nakashima. "Immunological responses against human papilloma virus and human papilloma virus induced laryngeal cancer." Journal of Laryngology & Otology 124, no. 6 (2010): 659–62. http://dx.doi.org/10.1017/s0022215110000617.

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AbstractObjective:This study aimed to clarify the local immune status in the larynx in the presence of infection or carcinogenesis associated with human papilloma virus.Methods:Cytological samples (for human papilloma virus detection) and laryngeal secretions (for immunoglobulin assessment) were obtained from 31 patients with laryngeal disease, during microscopic laryngeal surgery. On histological examination, 12 patients had squamous cell carcinoma, four had laryngeal papilloma and 15 had other benign laryngeal disease. Cytological samples were tested for human papilloma virus DNA using the H

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Wang, Dongying. "Bioinformatics Analysis of Immunoglobulin ε (IgE) Heavy Chain". International Journal of Biology and Life Sciences 5, № 1 (2024): 25–28. http://dx.doi.org/10.54097/9yvrbm43.

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Abstract (sommario):

Immunoglobulin ε is a key immunoglobulin that plays an important role in the immune system. IgE is usually associated with allergic reactions such as food allergies, allergic rhinitis, and allergic dermatitis. In this project, this article Use NCBI or https://www.uniprot.org/ Website to obtain immunoglobulins ε Heavy chain related nucleotide sequences. Using relevant websites and software to analyze and predict immunoglobulins using bioinformatics methods ε Bioinformatics analysis of heavy chains includes physical and chemical properties, structural functions, positional expression, phylogenet

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Ul Ain, Qurat, Rabia Rasool, and Saliha Afsheen. "Young female with repeated chest and gastrointestinal infections." Infectious Diseases Journal of Pakistan 33, no. 4 (2024): 202–5. https://doi.org/10.61529/idjp.v33i4.300.

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Abstract (sommario):

Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency disorder characterised by reduced serum levels of immunoglobulin G (IgG), along with immunoglobulin A (IgA) and/or immunoglobulin M (IgM).1 The range of clinical manifestations is broad, including acute and chronic infections, inflammatory and autoimmune disease, and an increased incidence of cancer and lymphoma.2 We present a case of a young female with bronchial asthma, repeated chest infections, and a prolonged episode of gastroenteritis. After a detailed history, examination, and investigations, she was diagnose

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Peng, Xu, Xiao-Bi Xie, Hong Tan, et al. "Effects of Plasma Exchange Combined with Immunoglobulin Therapy on Consciousness, Immune Function, and Prognosis in Patients with Myasthenia Gravis Crisis: A Prospective Randomized Test." Computational and Mathematical Methods in Medicine 2022 (June 30, 2022): 1–7. http://dx.doi.org/10.1155/2022/7796833.

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Abstract (sommario):

Background. Myasthenia gravis (MG) is an acquired autoimmune disease. The main clinical features of MG are skeletal muscle fatigue and pathological fatigue, which worsen at night or after fatigue, such as dyspnea, dysphagia, and systemic weakness. Plasma exchange (PE) is often used in patients with acute exacerbation of MG. Intravenous immunoglobulin (IVIG) is a collection of immunoglobulins from thousands of donors. IVIG can replace a variety of immunosuppressants or PE. However, the effect of PE or IVIG on patients’ consciousness, immune function, and prognosis is not clear. Objective. A pro

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Lü, F. Xusheng, Zhongmin Ma, Tracy Rourke, Seema Srinivasan, Michael McChesney, and Christopher J. Miller. "Immunoglobulin Concentrations and Antigen-Specific Antibody Levels in Cervicovaginal Lavages of Rhesus Macaques Are Influenced by the Stage of the Menstrual Cycle." Infection and Immunity 67, no. 12 (1999): 6321–28. http://dx.doi.org/10.1128/iai.67.12.6321-6328.1999.

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Abstract (sommario):

ABSTRACT The levels of antigen-specific antibodies (Abs) and immunoglobulins in the cervical mucus of women vary with the menstrual cycle; the highest levels occur during menses, and the lowest occur during the periovulatory period. The rhesus macaque is a widely used animal model of female genital tract immunity. We sought to determine whether rhesus macaques have a cyclical pattern of changing cervicovaginal Ab and immunoglobulin levels that is similar to that of the human female. This study examined the relationship of the stages of the menstrual cycle to genital mucosal and systemic immuno

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Liyanage, K. L. D. Tharaka D., Paola K. Vaz, Abdul Jabbar, and Jasmin Hufschmid. "Towards a pan marsupial sero-immunological tool in the demanding field of wildlife serology: Marsupial immunoglobulin-binding capability with protein A/G, protein L and anti-kangaroo antibody." PLOS ONE 18, no. 12 (2023): e0295820. http://dx.doi.org/10.1371/journal.pone.0295820.

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Abstract (sommario):

Detection of infections in wildlife species is increasingly important to reduce the risk of spreading zoonotic and economically important parasites, understand disease epidemiology and promote the conservation of wildlife species. Serological tests are key in disease diagnosis and surveillance by detecting immunoglobulins against infectious agents. However, the need for species-specific reagents has limited the application of serological tests in wildlife species. This study evaluated the serum immunoglobulin-binding capability of polyclonal anti-kangaroo antibody and two non-species-specific

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White, Arthur G., Hamad A. Al Riyami, Padma Kuchipudi, and Abdallah S. Daar. "Immunoglobulins, Immunoglobulin G Subclasses and Complement in Adult Omanis." Annals of Saudi Medicine 17, no. 1 (1997): 39–42. http://dx.doi.org/10.5144/0256-4947.1997.39.

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Öner, Ahment Faik, Hüseyin Çaksen, Avni Çelik, Yasar Cesur, Abdurrahman Üner, and Sükrü Arslan. "Serum immunoglobulins and immunoglobulin G subclasses with recurrent wheezing." Indian Journal of Pediatrics 67, no. 12 (2000): 861–64. http://dx.doi.org/10.1007/bf02723943.

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Kovács, Ferenc, Marina Varga, Szilárd Szabó, and Katalin Bertók. "Isolated aspartate aminotransferase elevation in a young, healthy person. Case report." Orvosi Hetilap 155, no. 39 (2014): 1558–62. http://dx.doi.org/10.1556/oh.2014.29997.

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Abstract (sommario):

The authors present diagnostic methods used in a young healthy person who had isolated aspartate aminotransferase elevation. Polyethylene glycol precipitation test, aspartate aminotransferase serum electrophoresis and immunofixation were performed for measuring the macro-aspartate aminotransferase. It was found that aspartate aminotransferase activity in the patient was almost completely eliminated after precipitation of immunoglobulins with polyethylene glycol. In addtion, aspartate aminotransferase migrated in the control samples to the anode while in the patient towards the cathode. Finally

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