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Tesi sul tema "Immunology"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Kajbaf, Mohammad Javad. "Immunology of trachoma." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236213.

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2

Veenstra, van Nieuwenhoven Angélique L. "Immunology of pregnancy." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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3

Mangano, Valentina D. "Dissecting the complexity of human susceptibility to Plasmodium falciparum malaria : genetic approaches /." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8310.

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4

Hutchings, Nicholas James. "Proteome analysis in immunology." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393404.

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5

Venkatesan, Pradhib. "Immunology of murine giardiasis." Thesis, Nottingham Trent University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281702.

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6

Humphreys, Kenneth Andrew. "Intestinal immunology in man." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22330.

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Loss of IgG to the gut in patients with inflammatory bowel disease (IBD) can arise from plasma or by local production from cells in the lamina propria. The source of IgG in WGLF was shown to be predominantly plasma since the relative coefficient of excretion for IgG in WGLF was similar to albumin for all colonic IBD patients with a range of disease activity. As albumin is much mores susceptible to proteolysis than are immunoglobulins, the study was restricted to patients with colonic disease and without extremes of WGLF protease activity. It has been assumed that protein loss occurs from the s

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7

Bui, Naomi Nhu. "Immunology of Tumamoc Hill." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/319939.

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8

Tjärnlund, Anna. "Mucosal Immunity in Mycobacterial infections." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6782.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB, caused by the bacterium <i>Mycobacterium tuberculosis</i>, is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, BCG, is administered parenterally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucos

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9

Vafa, Manijeh. "Human genetic factors in relation to Plasmodium falciparum infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7136.

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10

Israelsson, Elisabeth. "The role of antibody mediated parasite neutralization in protective immunity against malaria." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7137.

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11

Sjögren, Ylva. "Early infant gut flora and neutral oligosaccharides in colostrum in relation to allergy development in children." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7152.

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<p>Today, atopic allergy is the most common chronic disease among children in the developed world. The increase in allergy prevalence during the past decades in these countries might be associated with lower microbial exposure. The gut flora, consisting of approximately 800 different species of bacteria, has been postulated to be important for the development of a fully functional immune system. Essentially, these bacteria are in constant contact with the gut flora associated lymphoid tissue, the largest lymphoid tissue of the human body. Following birth, the sterile gut of the newborn is imme

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12

Ali, Magdi Mahmoud. "Immunologic aspects of the pathogenesis of human onchocerciasis." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-793.

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<p>Onchocerciasis, or river blindness, is a parasitic disease that affects more than 20 million people globally. The induction of pathology is directly related to the presence and destruction of the microfilarial stages (mf) of this filarial nematode. The disease presents clinically with a wide spectrum of dermal and ocular manifestations, the basis of the variation is believed to involve the immune system. The clinical presentations of infected hosts relate to the intensity of the reactions against the parasite. Anti-microfilarial drugs are also thought to somehow involve the immune system in

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13

Rahman, Muhammad Jubayer. "Diagnostic biomarkers and improved vaccination against mycobacterial infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8238.

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<p>Tuberculosis (TB) remains one of the world’s most serious infectious diseases. It is estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against pulmonary TB, is controversial as reported with variable efficacy ranging from 0-80%. In addition to the problems associated with the BCG vaccine, diagnosis of TB cannot be performed readily with the available too

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14

Sundström, Yvonne. "Phenotypic and functional studies of NK cells in neonates and during early childhood." Doctoral thesis, Stockholms universitet, Wenner-Grens institut för experimentell biologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8258.

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During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesis aimed at investigating function and phenotype of NK cells in children from birth and during early childhood and to see if these features are altered in children that develop early allergy, in children latently infected by herpes viruses or born by preeclamptic mothers. Our results suggest that NK-

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15

Walldén, (Fredriksson) Jenny. "Studies of immunological risk factors in type 1 diabetes." Doctoral thesis, Linköpings universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12441.

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Background: Type 1 diabetes (T1D) is a chronic, autoimmune disease caused by a T cell mediated destruction of ß-cells in pancreas. The development of T1D is determined by a combination of genetic susceptibility genes and environmental factors involved in the pathogenesis of T1D. This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulatory T cells between healthy children, children at risk of T1D and T1D patients.

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16

Amoudruz, Petra. "Maternal immune characteristics and innate immune responses in the child in relation to allergic disease." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7818.

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The mechanistic factors responsible for the increase in allergic diseases are still not fully understood, but a reduced microbial stimulation seems to be one of the key issues. Research is now aiming at investigating the relationship between the innate immune system, involving the toll-like receptors, and allergy development. Further, the maternal influence on the child, possibly through in utero effects, but also through the breast milk, has shown to be of great importance. This thesis aimed at understanding how the maternal immune system is influenced by early exposures and allergic disease,

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17

Sohlberg, Ebba. "Innate immune responses in cord blood,and the influence of pathological pregnancy." Licentiate thesis, Stockholms universitet, Avdelningen för immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54575.

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18

Balogun, Halima Aramide. "Immunological characteristics of a C-terminal fragment of the Plasmodium falciparum blood-stage antigen Pf332." Licentiate thesis, Stockholms universitet, Wenner-Grens institut, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7143.

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Till date, there are no effective control strategies against the deadly disease of malaria, and millions of children across Africa, Oceania, Asia, and Latin America are at the mercy of this long term enemy of man every second that passes by. Other control measures combined with vaccination might help improve control strategy against malaria, but the development of vaccines face various challenges as well, due to the complexity of the parasites’ life cycle and other host factors. The asexual blood stage antigen Pf332 of Plasmodium falciparum, is expressed during the trophozoite stage, and trans

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19

Awah, Nancy. "Malarial anaemia : the potential involvement of Plasmodium falciparum rhoptry proteins." Licentiate thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8460.

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Malaria remains a challenging health problem in malaria endemic regions. Infection with malaria invariably leads to anaemia. The groups at risk of developing malarial anaemia include children below the age of five years and pregnant women, especially primigravidae. Several factors have been suggested to be responsible for its aetiology, including increased destruction of infected and normal red blood cells together with bone marrow suppression. However, until recently, the molecular mechanisms involved have remained elusive. The aim of the work presented herein was to investigate the mechanism

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20

Newsom-Davis, Thomas Edmund. "Fas Ligand and Tumour Immunology." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486884.

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Fas ligand (FasL) is a transmembrane protein which induces apoptosis in cells expressing its receptor, Fas. The FasL/Fas pathway is one ofthe major mediators of cell death in the immune system but more recently an inflammatory role has been suggested. This thesis investigated the finding that when injected into mice, FasL-expressing (FasL+) tumours recruit a massive polymorphonuclear neutrophil (PMN) infiltration and are then rejected, which is followed by the development of antibody mediated tumour immunity. . In this work, eight IgM and one IgG2a monoclonal antibodies (mAbs) were produced fr

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21

Howes, Moira Ann. "Immunology and the indiscrete self." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0008/NQ42530.pdf.

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22

Sheu, Eric G. "Immunology of T cell vaccines." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288552.

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23

Figueredo, Grazziela P. "Translating simulation approaches for immunology." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12905/.

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This thesis presents a novel set of guidelines to convert between simulation modelling approaches, namely, Ordinary differential Equations (ODEs), System Dynamics (SD) and Agent-based Modelling and Simulation (ABMS). In our literature review we identify a gap in establishing translation techniques between these approaches. We therefore focus our research in developing these techniques and assessing the impact of these conversions in the simulation outcomes. In particular, our interest lies in investigating our techniques applied to simulation problems for the immune system, as we wish to aid i

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24

Zhao, Yuan. "Immunology of granulomatosis with polyangiitis." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/immunology-of-granulomatosis-with-polyangiitis(91230752-735f-41ea-8695-f26f8b2e5c97).html.

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Granulomatosis with polyangiitis (GPA, formerly known as Wegener’s granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for proteinase 3 (PR3) are associated with GPA. However, the pathogenesis of GPA is not yet clear. Our aim was to investigate the local autoimmune response, circulating immune modulatory cells and cells expressing the immune suppressor molecules programmed death 1 (PD-1) and its ligands in GPA. In mucosa from GPA patients, activated B cells were observed located alongside PR3 expressing cells and B

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25

Thompson, Fiona Mary. "Malaria immunology and vaccine development." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67626/.

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This thesis describes work undertaken by the author at the University of Oxford. It begins by providing an introduction to malaria infection and pathophysiology, and a review of the latest attempts to produce an effective malaria vaccine. It goes on to describe the rationale behind the vaccines developed by the University of Oxford and others. A brief introduction to the process of planning and carrying out clinical trials of vaccines is then provided, and is followed by chapters describing two clinical trials, designed to test the safety, immunogenicity and then efficacy of candidate malaria

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26

Parney, Ian Frederick. "Human glioma immunology and immunogene therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0003/NQ39580.pdf.

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27

Klingström, Jonas. "Hantaviruses : animal models, immunology and pathogenesis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-071-0/.

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28

Rodgers, Jackie Michele. "The immunology of hydrocephalus shunt infections." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246215.

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29

Chlon, Leon. "Machine learning methods for cancer immunology." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/268068.

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Tumours are highly heterogeneous collections of tissues characterised by a repertoire of heavily mutated and rapidly proliferating cells. Evading immune destruction is a fundamental hallmark of cancer, and elucidating the contextual basis of tumour-infiltrating leukocytes is pivotal for improving immunotherapy initiatives. However, progress in this domain is hindered by an incomplete characterisation of the regulatory mechanisms involved in cancer immunity. Addressing this challenge, this thesis is formulated around a fundamental line of inquiry: how do we quantitatively describe the immune sy

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30

Rezvan, Hossein. "Studies on immunology of Leishmania mexicana." Thesis, Nottingham Trent University, 2007. http://irep.ntu.ac.uk/id/eprint/181/.

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Leishmaniasis is a worldwide disease prevalent in many tropical and sub tropical countries. Treatment of Leishmaniasis by chemotherapy is not wholly effective and is usually accompanied by unpleasant side effects. The development of an effective and inexpensive vaccine represents a practical way to control the disease, however at present no safe and effective vaccine is available. In the first part of the present study, the immunity induced by four different L. mexicana potential vaccines, including killed leishmania vaccine, Soluble L. mexicana Antigen (SLA), L. mexicana gp63 cDNA and CT26 tu

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31

Dodd, Will. "Pediatric Rheumatology, Heme-Onc, and Immunology." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8912.

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32

Hill, Bruce Derick. "The pathobiology and immunology of cryptosporidiosis." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/30269.

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33

Leber, Andrew James. "Systems Immunology Approaches for Precision Medicine." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78233.

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Abstract (sommario):

The mucosal immune system encompasses a wide array of interactions that work in concert to protect an individual from harmful agents while retaining tolerance to molecules, microbes, and self-antigens that present no danger. The upheaval in the regulation-response balance is a critical aspect in both infectious and immune-mediated disease. To understand this balance and methods of its restoration, iterative and integrative modeling cycles on the pathogenesis of disease are necessary. In this thesis, I present three studies highlighting phases of a systems immunology cycle. Firstly, the thesis

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34

Doyle, Chloe. "Investigating The Immunology Of Crohn’s Disease." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29965.

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Crohn’s disease is a chronic autoimmune disease characterised by chronic inflammation in the gastrointestinal tract caused by an uncontrolled immune reaction to commensal bacteria. It is steadily increasing in incidence across the globe, especially in young adults. Current treatments act to reduce inflammation but there is no cure. This is because this disease is still poorly understood especially regarding the specific immune cells involved. Defining these cells and their functions could provide critical insights into the causes and progression of this disease and pave the way for therapeutic

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35

Ngo, Chinh Chung. "Microbiology and Immunology of Otitis Media." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/365263.

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Background Over 80% of children experience acute otitis media (AOM) at least once during childhood, with 10-30% of children experiencing recurrent episodes of AOM (RAOM) or persistence of fluid in the middle ear (ME) lasting greater than 3 months which is defined as chronic otitis media with effusion (COME). Microbial infection remains the main cause of AOM, however the causes of RAOM and COME are not fully understood. Heavy loads of microbial colonisation and bacterial/viral interaction in the upper respiratory tract (URT) contribute to OM pathogenesis. It is currently unclear whether comprom

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36

Tjärnlund, Anna. "Does IgA play a role in protection against pulmonary tuberculosis?" Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-552.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, <i>Mycobacterium bovis</i> bacillus Calmette-Guérin (BCG), is administered parentally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucosal immun

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37

Arko-Mensah, John. "Immune evasion and identification of biomarkers associated with mycobacterial infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7253.

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38

Johansson, Alina. "Molecular mechanisms behind TRIM28expression." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252834.

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39

Andersson, Jonas. "Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3410.

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40

Mouchtaridi, Elli. "The role of exosomes in sarcoidosis." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446010.

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Sarcoidosis is a systemic inflammatory disease mostly affecting the lungs, marked by the presence of granulomas and the accumulation of interferon gamma (IFNγ)-producing T cells in the affected organs. Extracellular vesicles (EVs) are membranous vesicles with a size range of 50 nm to 5000 nm, with exosomes ranging from 50 to 150 nm. They are major players in intercellular communication and have been found in all body fluids including plasma. In this study, we wanted to characterize the exosomes from sarcoidosis patients’ plasma and try to detect differences in their surface marker expression.

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41

Mullazehi, Mohammed. "Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100483.

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Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. Anti-CII can form surface-bound immune complexes (IC) in inflamed joints, which might intensify joint inflammation and destruction. In this thesis I have studied the functional effects of surface-bound anti-CII–containing IC in vitro and correlated the results to clinical parameters. Anti-CII IC induced TN

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42

Åhlin, Erik. "Functional Role of Immune Complexes in Rheumatic and Parasitic Diseases." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139529.

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Immune complexes (IC) have key pathological roles in both autoimmune and infectious diseases. In this thesis functional mechanisms behind IC-driven inflammation in rheumatic diseases and tropical infections have been studied, with special focus on the contribution of autoantibodies and cytokine-inducing properties of IC. In the autoimmune disease SLE, increased levels of IC-induced cytokines were associated with both increased classical complement activation and the occurrence of the autoantibodies anti-SSA and anti-SSB, both directed against RNA-associated antigens. In addition, complement ac

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43

Andersson, Josefin. "Utvärdering av Malaria Antigen ELISA kit för diagnostik av malaria vid Christian Medical College and Hospital i Vellore, Indien. : en jämförande studie mellan Quantitative buffy coat och enzyme-linked immunosorbent assays (ELISA) metodik." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-4889.

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Abstract (sommario):

Malaria är ett globalt hälsoproblem som orsakar många dödsfall runt om i världen varje år och nästan hälften av jordens befolkning ligger i riskzonen att drabbas av sjukdomen. I Indien drabbas mellan 2-3 miljoner människor varje år och det inträffar omkring 900 dödsfall. Malaria orsakas av Plasmodium sp. som är en protozoe, och det finns fyra olika arter som är patogena för människor, P. vivax, P. ovale, P. falciparium samt P. malariae. Vanliga metoder för att diagnostisera malaria är genom tunna och tjocka blodutstryk som färgas till exempel med Giemsa, Fields eller Leishmans färgningsteknik

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44

Martin, Melina Toni Marie. "The effects of probiotic and dietary fiber administration on intestinal physiological markers in pigs." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-416249.

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45

Lindroth, Karin. "Maturation of humoral immune responses : Studies on the effects of antigen type, apoptosis and age." Doctoral thesis, Stockholm : Wenner-Grens institut, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-85.

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46

Douguet, Laetitia. "Conséquences de l’expression de la synthétase de l’oxyde nitrique de type 2 (NOS2) sur les fonctions des lymphocytes T γδ au cours du développement du mélanome". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB106/document.

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Au cours du développement d’un cancer, la tumeur se forme dans un environnement adapté à sa croissance appelé microenvironnement tumoral. Celui-ci est constitué d’un réseau complexe qui orchestre la progression tumorale et dans lequel sont présents différents types cellulaires, des facteurs solubles ainsi que des composants de la matrice extracellulaire. Parmi les cellules du microenvironnement tumoral, on trouve les cellules du système immunitaire. Certaines ont la capacité de reconnaître et d’éliminer directement les cellules cancéreuses, tandis que d’autres promeuvent la croissance tumorale

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47

Wirth, Monika. "Immunology of the genital tract - a review." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-68316.

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48

Cozzi, E. "The immunology of pig-to-primate xenotransplantation." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598114.

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This thesis describes the analysis of transgenic pigs expressing the human regulatory protein decay-accelerating factor (HDAF). The first part of this research was aimed at proving the success of the genetic manipulation undertaken, by demonstrating the existence of HDAF in these transgenic pigs. These studies, conducted on PBMC from founder animals, provided evidence that both lymphocytes and monocytes from most transgenic pigs analysed express the HDAF protein. As altered expression and function of human proteins in transgenic pigs had previously been reported, the HDAF was further character

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49

Yang, Demao. "Immunology of membrane proteins of Leishmania major." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304854.

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Mair, T. S. "Respiratory immunology and hypersensitivity in the horse." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370896.

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