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Tesi sul tema "Inbred mice"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 6 febbraio 2022

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1

Langford, Christopher Patrick. "Repeated infection of inbred mice with Heligmosomoides polygyus." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46403.

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2

Byers, Shannon L. "Use of Inbred Strains of Mice to Study the Genetics and Biology of Sperm Function." Fogler Library, University of Maine, 2006. http://www.library.umaine.edu/theses/pdf/ByersSL2006.pdf.

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3

Wood, Erin. "A Behavioral Comparison of Four Inbred Strains of Mice." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2224.

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Isogenic, or inbred, mouse strains are currently the experimental subjects of choice in laboratory studies focused on genetics, pharmacology, and psychological issues. Understanding phenotypic differences in isogenic strains is important in order to interpret experimental results obtained from inbred mouse strains. Four commonly used inbred strains, C57BL/6NHsd (C57), DBA/2NHsd (DBA), 129S2/SvHsd (129), and Balb/cAnHsd (Balb/c), are investigated in this study using four different behavioral tasks that measure locomotor activity and cognitive behavior (Morris Water Maze (MWM), T-maze, and

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4

Peugh, W. N. "The genetics and immunology of cardiac allograft rejection in inbred mice." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375315.

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5

Liu, Dien. "Effects of R294C mutation on expression and stability of interferon regulatory factor-8 in BXH-2 mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116090.

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Interferon regulatory factor-8 (Irf-8), a hematopoietic transcriptional regulator, controls myeloid-cell proliferation and coordinates innate and adaptive host immune responses. Mice from the BXH-2 recombinant inbred strain carry an endogenous R294C mutation in Irf-8. This loss-of-function mutation induces clonal infiltration of undifferentiated Mac-1+/Gr-1 + granulocytic precursors in BXH-2 mice, extramedullary hematopoiesis, and splenomegaly similar to those seen in human chronic myeloid leukemia. It also renders the host permissible to the otherwise avirulent Mycobacterium bovis (BCG), and

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6

Cushnie, Duncan Wells. "On the expression and deficiency of 5,10-methylenetetrahydrofolate reductase in murine sperm development." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116083.

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Development of specific DNA methylation patterns is required for normal spermatogenesis. DNA methyltransferases (DNMTs) use S-adenosylmethionine (SAM) produced in a pathway requiring 5,10-methylenetetrahydrofolate reductase (MTHFR). This thesis describes: testicular phenotype differences derived from Mthfr-deficiency in different mouse strains; the cellular Mthfr expression pattern during male germ cell development; and finally, changes to the DNA methylation of Mthfr-deficient sperm. Mthfr-deficient BALB/c, but not C57BL/6, mice have reduced neonatal germ cell proliferation but both have abno

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7

Knock, Erin Heather 1981. "Long-term dietary folate deficiency and intestinal tumor development in mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115689.

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Epidemiological evidence linking dietary folate deficiency and risk for colorectal cancer is conflicting. Studies using animal models indicate that timing, dose and presence of pre-malignant lesions will influence whether folate deficiency prevents or promotes tumor formation. In this thesis a new model of spontaneous tumor formation due to long-term dietary folate deficiency alone, in non-transgenic mice and without carcinogen induction, is developed. The mechanisms by which folate deficiency might influence cancer risk are also examined.<br>BALB/c mice, with or without a null allele in a key

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8

Pereira, Bernardo Acácio Santini. "Leishmania (Leishmania) amazonensis: participação de fatores do hospedeiro e do parasito no curso da infecção experimental em camundongos." reponame:Repositório Institucional da FIOCRUZ, 2010. https://www.arca.fiocruz.br/handle/icict/4112.

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Submitted by Tatiana Oliveira (tsilva@icict.fiocruz.br) on 2012-05-31T16:59:24Z No. of bitstreams: 1 bernardo_as_pereira_ioc_bp_002_2010.pdf: 3428909 bytes, checksum: 68f2b1087a42200dd708a3f10aac479e (MD5)<br>Made available in DSpace on 2012-05-31T16:59:24Z (GMT). No. of bitstreams: 1 bernardo_as_pereira_ioc_bp_002_2010.pdf: 3428909 bytes, checksum: 68f2b1087a42200dd708a3f10aac479e (MD5) Previous issue date: 2010<br>Fundação Oswaldo Cruz.Instituto Oswaldo Cruz. Rio de janeiro, RJ, Brasil<br>A leishmaniose é uma doença antropozoonose que afeta 88 países, o que denota a importância da realizaç

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9

Wang, Chengming Kaltenboeck Bernhard. "Multivariate analysis of Chlamydia pneumoniae lung infection in two inbred mouse strains." Auburn, Ala., 2005. http://hdl.handle.net/10415/1260.

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10

Wong, Andrew Wai Kit. "Correlations between hippocampal synaptic plasticities and proteins, in inbred mice and in transgenic mice modelling Alzheimer's disease, and behaviour." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408247.

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11

Cotsapas, Chris Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "The genetics of variation in gene expression." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/30204.

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The majority of genetic differences between species and individuals have been hypothesised to impact on the regulation, rather than the structure, of genes. As the details of genetic variation are uncovered by the various genome sequencing projects, understanding the functional effects on gene regulation will be key to uncovering the molecular mechanisms underying the genesis and inheritance of common phenotypes, such as complex human disease and commercially important traits in plants and animals. Unlike coding sequence polymorphisms, genetic variants affecting gene expression will reside in

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12

Maema, Malefane M. "Dynamics of repeated infection of high and low responder inbred mice with Heligmosomoides polygyrus." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38092.

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13

Eastgard, Rebecca Lugar. "Diet-induced hyperhomocysteinemia in a mouse model /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/6601.

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14

Hickey, Evan Thaler. "Nicotinic cholinergic modulation of sensorimotor gating and working memory in two strains of inbred mice." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=20125.

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Nicotinic acetylcholine receptor (nAChR) stimulation has been found to enhance sensorimotor gating and the trial-specific store of mutable information known as working memory. Working memory function is dependent upon effective stimulus filtering, which leads to the question as to whether nAChR agonists augment working memory function directly, or whether this effect is mediated indirectly through a strengthening of sensorimotor gating. In the present studies, the C57BL/6J and 129X1/SvJ strains of inbred mice were tested at 2 and 8 months of age in the pre-pulse inhibition paradigm (PPI) and t

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15

Redwood, Alec J. "Cytokine gene expression patterns and immune responses to systemic Candida albicans infection in inbred mice." Curtin University of Technology, School of Biomedical Sciences, 1997. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=10970.

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Aims of the research:To characterise the tissue histology and tissue distribution patterns of C. albicans during systemic murine candidiasis.To develop a reliable, reproducible and sensitive SQ-RT-PCR for the quantitation of in vivo cytokine gene transcription.To use this technique to determine the in vivo pattern of tissue specific cytokine gene expression during systemic candidiasis.To determine if cytokine gene expression patterns vary between resistant BALB/c and sensitive CBA/CaH mice during primary systemic candidiasis.To determine if differences in tissue distribution of C. albicans in

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16

Choi, Peter. "An analysis of the genetic control of interleukin-4 production in inbred strains of mice." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404427.

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17

Eom, Tae-Yeon. "Regulation of neural precursor cell apoptosis and proliferation by glycogen synthase kinase-3." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/eom.pdf.

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18

Abdul-Majid, Khairul-Bariah. "Pathogenesis of myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in DBA/1 mice /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-112-8/.

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19

Skabardonis, George P. "Genetic analysis of cerebellar folial pattern in crosses of A/J and C57BL/6J inbred mice." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24983.pdf.

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20

Shultz, Christopher L. "Kinetics of the Immune Response in Inbred and Outbred Mice Before and After Bone Marrow Transplantation." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/144956.

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21

Ho, Man Ki Maggie. "Factors contributing to altered insulin levels of PWD/PhJ and WSB/EiJ wild-derived inbred mice." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/46452.

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Insulin is a key hormone in the regulation of blood glucose. Type 2 diabetes (T2D) results from insufficient insulin-producing β cells in pancreatic islets or insufficient insulin secretion to maintain glucose homeostasis. Genetic variability is a major factor affecting type 2 diabetes (T2D) development. Two inbred mouse strains derived from wild caught mice, PWD/PhJ (PWD) and WSB/EiJ (WSB), have novel genetic variation relative to the classically-studied mice, C57BL/6J (B6), which will assist genetic studies. PWD and WSB mice exhibit high and low insulin levels, respectively, without insulin

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22

Murphy, Stephanie A. "Effects of selenium and vitamin B-6 on growth of chemically- induced transplanted tumors in BALB/c inbred mice." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/43906.

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Male weanling inbred, mice were inoculated with fibrosarcoma cells (hindquarter) originally produced by 2-methylcholanthrene. Before inoculation, mice were randomly divided into three groups of 24 and one of 12 (control). After a one week acclimation period, each group was fed a diet containing either suboptimal vitamin B-6, 0.5 mg/kg diet; adequate, 7.0 mg/kg diet; or excess, 100 mg/kg diet. Controls were fed the adequate vitamin. B-6 diet. Twenty-four hours after tumor cell inoculation, a series of sodium selenite injections (0.5 Î¼g/.10 mL) were given to half of each treatment group and

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23

O'steen, Jennifer Robin. "Prepulse Inhibition and the Acoustic Startle Response in Nine Inbred Mouse Strains." Scholar Commons, 2003. https://scholarcommons.usf.edu/etd/1443.

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This study examined the effects of genetic background on the acoustic startle response (ASR) and its modulation by prepulse inhibition (PPI) by comparing nine inbred strains of mice. The ASR, a jerk-like motor reflex, is elicited by bursts of noise or tones with sound pressure levels of 80-90 dB and greater. PPI is a type of modulation of the ASR, requires no training, and results in observable response in both mice and humans. Data were obtained from nine inbred mouse strains, sixteen per strain, which were shipped at approximately 3-5 weeks old from The Jackson Laboratory. In general, ASRs w

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24

Duarte, Nadia. "Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes /." Umeå : Medical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-601.

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25

Galdones, Eugene. "The role of retinoic acid receptor gamma in retinoid-induced limb dysmorphogenesis /." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115711.

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Retinol (vitamin A) and its active metabolite, all-trans retinoic acid, signal through nuclear retinoic acid and retinoid X receptor (RAR/RXR) heterodimers. These complexes regulate the expression of genes involved in developmental processes such as limb development. In excess, retinoids are potent teratogens and cause marked reductive effects on the developing limb. The goal of this thesis was to elucidate the molecular mechanisms underlying retinoid-induced limb dysmorphogenesis. Specifically, using an in vitro limb culture system, I examined the involvement of one RAR isoform, RARgamma, in

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26

Rubin, Matthew Aaron. "Multiscale characterization of the ultrastructure of trabecular bone in osteoporotic and normal humans and in two inbred strains of mice." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/18949.

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27

Marchica, Cinzia Loreta 1984. "Allergen-induced asthma is decreased in decorin-deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116096.

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Decorin, is an extracellular matrix proteoglycan with important biological functions. Decorin deficiency affects collagen fibrillogenesis, airway mechanics, airway-parenchymal interdependence, and airway smooth muscle proliferation and apoptosis. We questioned whether decorin deficiency would alter allergen-induced asthma in a mouse model. Decorin-/- and decorin+/+ mice (C57Bl/6) were sensitized and challenged with ovalbumin. Control animals received saline. Responsiveness was assessed at baseline and after delivery of increasing concentrations of methacholine. Histological analyses were also

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28

Hardaway, John C. Zaghouani Habib. "Examination of neonatal immunity in IL-13 receptor alpha 1 deficient mice." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6977.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010). Vita. Thesis advisor: Habib Zaghouani. Includes bibliographical references.

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29

Ghasemlou, Nader. "Cellular and molecular characterization of inflammation in the injured spinal cord." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111906.

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Spinal cord injury (SCI) results in a well-orchestrated inflammatory response which causes secondary tissue damage. Activated macrophages contribute to this cytotoxic response, which includes damage to neurons, glia and myelin, and tissue loss that worsens functional outcomes after SCI. However, activated macrophages in the spinal cord under other conditions are not cytotoxic, such as after intraspinal injection of lysophosphatidylcholine (LPC), a potent demyelinating agent. Recovery from SCI may be optimized by reducing the detrimental effects of macrophages while promoting their beneficial o

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30

Yang, Lanjian 1976. "Effect of DNA methyltransferase 1 on transmission ratio distortion and epigenetic inheritance." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116080.

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Epigenetic modification of DNA plays an important role in gene regulation. During gametogenesis and early embryogenesis epigenetic states are reset to ensure embryonic-specific gene expression patterns after fertilization. However, certain genomic regions may resist epigenetic reprogramming. This may result in transgenerational epigenetic inheritance. Earlier, a grandparental origin dependent (GPO) transmission ratio distortion (TRD) of alleles in the distal region of mouse chromosome 12 had been found (Croteau et al ., 2002). The distorted region overlaps with the imprinted region of chromoso

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31

Dhaher, Ronnie. "Determining the role of the extended amygdala in regulating alcohol consumption in C57BL/6J mice : a dissertation." Oregon Health & Science University, 2007. http://content.ohsu.edu/u?/etd,644.

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Ph.D.<br>Behavioral Neuroscience<br>The purpose of the research described in this dissertation was to determine the neural circuits involved with baseline ethanol consumption and increases in ethanol consumption seen in our animal model of ethanol dependency (further described below). The brain region of focus was the central extended amygdala (cEA) since this region has been shown to be involved in baseline consumption and self-administration of ethanol in rats (Hyytia & Koob, 1995; Eiler et al., 2002) and the changes in ethanol consumption induced by chronic intermittent ethanol vapor exposu

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32

Rossi, Thiago. "Estudo do efeito do gangliosideo GM1 sobre os nervos perifericos do camundongo NOD (Non Obese Diabetic)." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311769.

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Orientador: Ricardo de Lima Zollner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T03:27:40Z (GMT). No. of bitstreams: 1 Rossi_Thiago_M.pdf: 1494758 bytes, checksum: f7e58a6f6f514ba2db33bcbae7ab9586 (MD5) Previous issue date: 2007<br>Resumo: A linhagem de camundongos NOD (non obese diabetic) desenvolve espontaneamente diabetes mellitus tipo 1 (DM-1) com marcante similaridade ao observado em humanos, que se estabelece entre 12ª e 24ª semana de vida. Os gangliosideos são glicoesfingolipídeos de membrana que

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33

Johansson, Sofia. "NK cell recognition : adaptability to host factors in normal and diabetic mice /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-317-5/.

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34

Motta, Vinícius. "The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice /." Umeå : Department of Medical Biosciences, Umeå University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-728.

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35

Campbell, Holly R. 1976. "Chlorine-induced lung injury and the role of iNOS." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111574.

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Reactive airways dysfunction syndrome (RADS), a form of irritant-induced asthma (IIA) has been observed in humans following acute chlorine (Cl 2) gas exposure in occupational and domestic settings. Following Cl 2 injury, subepithelial fibrosis, mucous hyperplasia, and non-specific airway hyperresponsiveness have been reported. Based on the disease profile, we hypothesized that pulmonary damage may be oxidative in nature.<br>The aim of this work was to develop a murine model of irritant-induced asthma in order to investigate the pathogenic processes and potential oxidative mechanisms involved i

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36

Pearson, Todd. "The Genetic Basis of Resistance to Transplantation Tolerance Induced by Costimulation Blockade in NOD Mice: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/16.

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The NOD mouse is a widely studied model of type 1 diabetes. The loss of self-tolerance leading to autoimmune diabetes in NOD mice involves at least 27 genetic loci. Curing type I diabetes in mice and humans by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction would be preferable. In addition to their genetic defects in self-tolerance, NOD mice resist peripheral transplantation tolerance induced by costimulation blockade using donor-specific transfusion and anti-CDl54 antibody.

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37

Hu, Wei. "Genomic determinants of alcohol effects /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008. http://proquest.umi.com/pqdweb?did=1545571871&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 121-149). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;

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38

Sales, Loyane Almeida Gama. "Caracterização da motilidade e morfologia gastrintestinal em camundongos BALB/c e C57BL/6J." Botucatu, 2019. http://hdl.handle.net/11449/181781.

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Orientador: Madileine Francely Américo<br>Resumo: A contratilidade do músculo liso e o trânsito gastrintestinal (GI) são importantes parâmetros da motilidade, cujas alterações podem comprometer a absorção de nutrientes e a biodisponibilidade de fármacos. Diversos fármacos apresentam efeitos adversos associados ao trato GI e, mesmo aqueles utilizados para controlar esses efeitos, podem provocar alterações importantes na motilidade ainda pouco conhecidas. Camundongos das linhagens C57BL/6 e BALB/c são amplamente utilizados nas pesquisas biomédicas, entretanto poucos estudos consideram os parâmet

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Hermes, Túlio de Almeida 1991. "Influência do cilostazol na degeneração muscular de camundongos MDX." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317502.

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Orientador: Elaine Minatel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-27T05:53:09Z (GMT). No. of bitstreams: 1 Hermes_TuliodeAlmeida_M.pdf: 2416913 bytes, checksum: 6780cc171b5db72eb9dd72aa61ad89b1 (MD5) Previous issue date: 2015<br>Resumo: Estresse oxidativo e resposta inflamatória exacerbada são fatores que contribuem com a fisiopatogênese da distrofia muscular de Duchenne (DMD). No presente trabalho, avaliamos se a administração de Cilostazol, antes que se iniciem os ciclos degeneração/regeneração, diminui a

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40

Chou, Ping-Jen. "The Modulation by Anthrax Toxins of Dendritic Cell Activation." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002791.

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41

Chagnon, Mélanie J. 1977. "Physiological and molecular functions of the murine receptor protein tyrosine phosphatase sigma (RPTP[sigma])." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115661.

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The control of cellular tyrosine phosphorylation levels is of great importance in many biological systems. Among the kinases and phosphatases that modulate these levels, the LAR-RPTPs have been suggested to act in several key aspects of neural development, and in a dysfunctional manner in various pathologies from diabetes to cancer. The aim of this thesis is to describe the physiological functions of one of the members of this subfamily of RPTPs, namely RPTPsigma. First, we showed that glucose homeostasis is altered in RPTPsigma null mice. They are hypoglycemic and more sensitive to exogenous

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42

Tonkin, Daniel R. "TGF-[beta]-induced regulatory T cells in type I diabetes : function and antigen dependence /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 182-202). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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43

Gregg, Randal K. "Mechanisms underlying diabetogenesis in the NOD mouse." Free to MU campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3115548.

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44

Cui, Yue. "Biologie des cellules MAIT chez la souris." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T039/document.

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Les cellules T invariantes associées aux muqueuse (MAIT) sont des lymphocytes innés caractérisés par l'expression d'un récepteur des cellules T semi-invariant (iTCR) et restreints par la molécule du complexe majeur d'histocompatibilité de classe Ib, MR1. Chez l'homme, les cellules MAIT sont abondantes dans le sang (1 à 10%), l'intestin (3 à 5%) et le foie (20 à 40%) et réagissent contre des métabolites microbiens. En raison de leur rareté dans les souris de laboratoire classiques, les études sur les cellules MAIT murines ont été principalement effectuées sur des souris transgéniques (Tg) pour

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45

Yin, Zhi-Jun. "Effects of Long-Term Exposure of Normal C57bl/6j Inbred Mice to 17beta-Estradiol on Gene Expression in Lymphocytes: Mrna Analysis of Lymphokines and Bcl-2/Fas." Thesis, Virginia Tech, 1997. http://hdl.handle.net/10919/46513.

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It is now clear that human and animal exposure to estrogenic compound occurs through several sources. This include: i) naturally occurring endogenous estrogens, ii) exogenous or intentional estrogens for prophylactic (e.g. oral contraceptive) and therapeutic (e.g. as replacement therapy for ovulation in nulliparous women and in menopausal women, and in some men suffering from prostate cancer) purposes, iii) accidental via estrogenic chemical exposure (e.g. pesticides, industrial byproducts) and phytoestrogens (e.g. soybeans). It has long been recognized that estrogen, a female sex hormone, f

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46

Burgos, Rafael Ramos de 1981. "Influência da nifedipina e da coenzima Q10 no processo de degeneração/regeneração muscular em camundongos mdx." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317504.

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Orientador: Elaine Minatel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-23T10:31:19Z (GMT). No. of bitstreams: 1 Burgos_RafaelRamosde_M.pdf: 2000317 bytes, checksum: 3ec9bdb6204407b72a6bd5378a5656ae (MD5) Previous issue date: 2013<br>Resumo: Tratamentos com antioxidantes e bloqueadores de canais de cálcio têm apresentado resultados positivos na diminuição da mionecrose nas fibras musculares distróficas. O objetivo do presente projeto foi verificar se o tratamento com o bloqueador de cálcio Nifedipina (Ni) e o anti

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Colomeu, Talita Cristina 1987. "Avaliação da atividade antioxidante e dos efeitos do consumo crônico do extrato aquoso de Passiflora alata Curtis na expressão do diabetes mellitus tipo 1 em camundongos NOD (non obese diabetic)." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311763.

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Orientador: Ricardo de Lima Zollner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T16:26:14Z (GMT). No. of bitstreams: 1 Colomeu_TalitaCristina_M.pdf: 1606110 bytes, checksum: ed843e2069440cf659e4ab7cc6c4c21f (MD5) Previous issue date: 2013<br>Resumo: A linhagem NOD (non obese diabetic) é utilizada como modelo experimental de DM-1, pois desenvolve espontaneamente a doença com marcante similaridade ao observado em humanos. Vários são os mecanismos propostos para ruptura da tolerância imunológica no DM-1, c

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Pereira, Juliano Alves 1983. "Tratamento da distrofinopatia em camundongos mdx : vantagens da associação entre doxiciclina e deflazacorte sobre a monoterapia com o deflazacorte." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317581.

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Orientador: Humberto Santo Neto<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-27T14:32:48Z (GMT). No. of bitstreams: 1 Pereira_JulianoAlves_D.pdf: 20174519 bytes, checksum: cb29b0264ecac77cff508a6dbc1ec270 (MD5) Previous issue date: 2015<br>Resumo: Na distrofia muscular de Duchenne (DMD) e no camundongo mdx, a ausência da distrofina no músculo esquelético e cardíaco, desestabiliza o sarcolema e leva a um aumento do influxo de cálcio e consequente mionecrose. A reação inflamatória induzida para remover a fibra muscular ne

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Malaguti, Carina 1981. "Avaliação dos efeitos da diacereina na modulação do diabetes mellitus e da expressão de citocinas pro-inflamatorias IL-1'beta', TNF-'alfa', IFN-'gama' e IL-12 em ilhotas 'beta' pancreaticas e celulas esplenicas no camundongo NOD (non obese diabetic)." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311778.

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Orientador: Ricardo de Lima Zollner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T20:34:25Z (GMT). No. of bitstreams: 1 Malaguti_Carina_M.pdf: 3081251 bytes, checksum: 464b9eb4c3ea569832e54a9ac80854a6 (MD5) Previous issue date: 2007<br>Resumo: O camundongo NOD é utilizado como modelo experimental por desenvolver diabetes mellitus tipo 1 (DM-1) espontâneo similar ao diabetes mellitus humano resultando na destruição das ilhotas, orquestrada pelos linfócitos T que induzem a liberação de citocinas, entre ela

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Dool, Carly Jade 1985. "Pharmacologic inhibition of insulin receptor tyrosine kinase activity has antineoplastic effects similar to alloxan-induced insulin deficiency with less acute metabolic toxicity." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111555.

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Recent population studies provide evidence that individuals with high circulating insulin levels have a poor prognosis and/or increased risk of cancer development; however, laboratory studies concerning the role of insulin in breast cancer biology are sparse. We compared the growth of 4T1 murine breast cancer allografts in control mice, alloxan-induced hypoinsulinemic mice, and mice treated with the insulin/insulin-like growth factor-1 receptor tyrosine kinase inhibitor BMS-536924. Both interventions significantly decreased tumor growth versus control and decreased pathway activation downstrea

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