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Letteratura scientifica selezionata sul tema "Interfacial tissues"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 2 febbraio 2022

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Articoli di riviste sul tema "Interfacial tissues"

Hench, Larry L., e Julia M. Polak. "A Genetic Basis for Design of Biomaterials for In Situ Tissue Regeneration". Key Engineering Materials 377 (marzo 2008): 151–66. http://dx.doi.org/10.4028/www.scientific.net/kem.377.151.

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Historically the function of biomaterials has been to replace diseased, damaged and aged tissues. First generation biomaterials, including bio ceramics, were selected to be as inert as possible in order to minimize the thickness of interfacial scar tissue. Bioactive glasses provided an alternative from the 1970’s onward; second generation bioactive bonding of implants with tissues and no interfacial scar tissue. This chapter reviews the discovery that controlled release of biologically active Ca and Si ions from bioactive glasses leads to the up-regulation and activation of seven families of genes in osteoprogenitor cells that give rise to rapid bone regeneration. This finding offers the possibility of creating a new generation of gene activating bioceramics designed specially for tissue engineering and in situ regeneration of tissues.

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Michel, Raphaël, Léna Poirier, Quentin van Poelvoorde, Josette Legagneux, Mathieu Manassero e Laurent Corté. "Interfacial fluid transport is a key to hydrogel bioadhesion". Proceedings of the National Academy of Sciences 116, n. 3 (2 gennaio 2019): 738–43. http://dx.doi.org/10.1073/pnas.1813208116.

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Attaching hydrogels to soft internal tissues is a key to the development of a number of biomedical devices. Nevertheless, the wet nature of hydrogels and tissues renders this adhesion most difficult to achieve and control. Here, we show that the transport of fluids across hydrogel−tissue interfaces plays a central role in adhesion. Using ex vivo peeling experiments on porcine liver, we characterized the adhesion between model hydrogel membranes and the liver capsule and parenchyma. By varying the contact time, the tissue hydration, and the swelling ratio of the hydrogel membrane, a transition between two peeling regimes is found: a lubricated regime where a liquid layer wets the interface, yielding low adhesion energies (0.1 J/m2 to 1 J/m2), and an adhesive regime with a solid binding between hydrogel and tissues and higher adhesion energies (1 J/m2 to 10 J/m2). We show that this transition corresponds to a draining of the interface inducing a local dehydration of the tissues, which become intrinsically adhesive. A simple model taking into account the microanatomy of tissues captures the transition for both the liver capsule and parenchyma. In vivo experiments demonstrate that this effect still holds on actively hydrated tissues like the liver capsule and show that adhesion can be strongly enhanced when using superabsorbent hydrogel meshes. These results shed light on the design of predictive bioadhesion tests as well as on the development of improved bioadhesive strategies exploiting interfacial fluid transport.

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Cerchiari, Alec E., James C. Garbe, Noel Y. Jee, Michael E. Todhunter, Kyle E. Broaders, Donna M. Peehl, Tejal A. Desai, Mark A. LaBarge, Matthew Thomson e Zev J. Gartner. "A strategy for tissue self-organization that is robust to cellular heterogeneity and plasticity". Proceedings of the National Academy of Sciences 112, n. 7 (29 gennaio 2015): 2287–92. http://dx.doi.org/10.1073/pnas.1410776112.

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Developing tissues contain motile populations of cells that can self-organize into spatially ordered tissues based on differences in their interfacial surface energies. However, it is unclear how self-organization by this mechanism remains robust when interfacial energies become heterogeneous in either time or space. The ducts and acini of the human mammary gland are prototypical heterogeneous and dynamic tissues comprising two concentrically arranged cell types. To investigate the consequences of cellular heterogeneity and plasticity on cell positioning in the mammary gland, we reconstituted its self-organization from aggregates of primary cells in vitro. We find that self-organization is dominated by the interfacial energy of the tissue–ECM boundary, rather than by differential homo- and heterotypic energies of cell–cell interaction. Surprisingly, interactions with the tissue–ECM boundary are binary, in that only one cell type interacts appreciably with the boundary. Using mathematical modeling and cell-type-specific knockdown of key regulators of cell–cell cohesion, we show that this strategy of self-organization is robust to severe perturbations affecting cell–cell contact formation. We also find that this mechanism of self-organization is conserved in the human prostate. Therefore, a binary interfacial interaction with the tissue boundary provides a flexible and generalizable strategy for forming and maintaining the structure of two-component tissues that exhibit abundant heterogeneity and plasticity. Our model also predicts that mutations affecting binary cell–ECM interactions are catastrophic and could contribute to loss of tissue architecture in diseases such as breast cancer.

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Grandfield, Kathryn, Anders Palmquist e Håkan Engqvist. "High-resolution three-dimensional probes of biomaterials and their interfaces". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 370, n. 1963 (28 marzo 2012): 1337–51. http://dx.doi.org/10.1098/rsta.2011.0253.

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Abstract (sommario):

Interfacial relationships between biomaterials and tissues strongly influence the success of implant materials and their long-term functionality. Owing to the inhomogeneity of biological tissues at an interface, in particular bone tissue, two-dimensional images often lack detail on the interfacial morphological complexity. Furthermore, the increasing use of nanotechnology in the design and production of biomaterials demands characterization techniques on a similar length scale. Electron tomography (ET) can meet these challenges by enabling high-resolution three-dimensional imaging of biomaterial interfaces. In this article, we review the fundamentals of ET and highlight its recent applications in probing the three-dimensional structure of bioceramics and their interfaces, with particular focus on the hydroxyapatite–bone interface, titanium dioxide–bone interface and a mesoporous titania coating for controlled drug release.

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Sahu, Preeti, Daniel M. Sussman, Matthias Rübsam, Aaron F. Mertz, Valerie Horsley, Eric R. Dufresne, Carien M. Niessen, M. Cristina Marchetti, M. Lisa Manning e J. M. Schwarz. "Small-scale demixing in confluent biological tissues". Soft Matter 16, n. 13 (2020): 3325–37. http://dx.doi.org/10.1039/c9sm01084j.

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While interfacial tension in confluent cellular mixtures leads to large-scale demixing, cell shape disparity leads to robust small-scale demixing that is observed in experiments and can be explained via neighbor exchange barriers at an interface.

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Mckee, Marc D., e Antonio Nanci. "Osteopontin: An Interfacial Extracellular Matrix Protein in Mineralized Tissues". Connective Tissue Research 35, n. 1-4 (gennaio 1996): 197–205. http://dx.doi.org/10.3109/03008209609029192.

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Foty, Ramsey A., Gabor Forgacs, Cathie M. Pfleger e Malcolm S. Steinberg. "Liquid properties of embryonic tissues: Measurement of interfacial tensions". Physical Review Letters 72, n. 14 (4 aprile 1994): 2298–301. http://dx.doi.org/10.1103/physrevlett.72.2298.

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Otagiri, Risa, Hideki Kawai, Masanobu Takatsuka, Naoki Shinyashiki, Akira Ito, Ryosuke Ikeguchi e Tomoki Aoyama. "Interfacial polarization of in vivo rat sciatic nerve with crush injury studied via broadband dielectric spectroscopy". PLOS ONE 16, n. 6 (2 giugno 2021): e0252589. http://dx.doi.org/10.1371/journal.pone.0252589.

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Electrical stimulation is one of the candidates for elongation-driven regeneration of damaged peripheral nerves. Different organs and tissues have an inherent cell structure and size. This leads to variation in the tissue-specific electrical properties of the frequency of interfacial polarization. Although nervous tissues have a membrane potential, the electrical reaction inside these tissues following electrical stimulation from outside remains unexplored. Furthermore, the pathophysiological reaction of an injured nerve is unclear. Here, we investigated the electrical reaction of injured and non-injured rat sciatic nerves via broadband dielectric spectroscopy. Crush injured and non-injured sciatic nerves of six 12-week-old male Lewis rats were used, 6 days after infliction of the injury. Both sides of the nerves (with and without injury) were exposed, and impedance measurements were performed at room temperature (approximately 25°C) at frequencies ranging from 100 mHz to 5.5 MHz and electric potential ranging from 0.100 to 1.00 V. The measured interfacial polarization potentially originated from the polarization by ion transport around nerve membranes at frequencies between 3.2 kHz and 1.6 MHz. The polarization strength of the injured nerves was smaller than that of non-injured nerves. However, the difference in polarization between injured and non-injured nerves might be caused by inflammation and edema. The suitable frequency range of the interfacial polarization can be expected to be critical for electrical stimulation of injured peripheral nerves.

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Lok, P., Philip Boughton, T. Kishen e Ashish D. Diwan. "Geometrical & Interfacial Modulation of a Biomimetic Spinal Implant". Journal of Biomimetics, Biomaterials and Tissue Engineering 4 (dicembre 2009): 41–58. http://dx.doi.org/10.4028/www.scientific.net/jbbte.4.41.

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The nucleus of a spinal disc is seamlessly connective and protectively supportive of the joint within which it is enveloped. A range of nucleus prosthesis configurations have been proposed and applied with some success. Those that have demonstrated clinical efficacy have approximated physiological form and function using established biomaterials while preserving key anatomical structures. The minimally invasive biostable, biomimetic Columna Disc Device (CDD) partial spinal disc replacement has been developed to clinical trial stage. It mimics the geometry and response of the nucleus that it replaces. While the implant configuration and materials have been set, the geometry and interfacial properties of this prosthesis may be modulated to account for versatility in surgical deployment, implant stiffness, and subsequent long-term tissue remodelling response. FEA models were developed to study effects of implant jacket geometry and surface properties on implant deployment and biomechanics. Studded and dimpled textures provide a method for increasing surface area to diffuse jacket-filler interfacial stress and similar for the implant-tissue junction. Surface texture design elements observed in nature can protect against delamination and interlayer slippage. This is the case with adherent outer layers of human skin. A textured implant design is also proposed to guard against third body wear by housing debris remote of wear sites and by reducing sliding. The periodically varying strain fields provided by the textured jacket may also help mitigate for tears by diverting and arresting micro-fissures. Increasing friction at the implant-tissue interface to the point of tissue-attachment was shown to increase the stiffness of the implant in axial-loading. In contrast, increasing bulk surface area is expected to contribute to a decrease in implant stiffness. This is, however, dependent on the intimacy and properties of interfacing tissues.

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Chen, Xiaoyu, Hyunwoo Yuk, Jingjing Wu, Christoph S. Nabzdyk e Xuanhe Zhao. "Instant tough bioadhesive with triggerable benign detachment". Proceedings of the National Academy of Sciences 117, n. 27 (23 giugno 2020): 15497–503. http://dx.doi.org/10.1073/pnas.2006389117.

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Bioadhesives such as tissue adhesives, hemostatic agents, and tissue sealants have potential advantages over sutures and staples for wound closure, hemostasis, and integration of implantable devices onto wet tissues. However, existing bioadhesives display several limitations including slow adhesion formation, weak bonding, low biocompatibility, poor mechanical match with tissues, and/or lack of triggerable benign detachment. Here, we report a bioadhesive that can form instant tough adhesion on various wet dynamic tissues and can be benignly detached from the adhered tissues on demand with a biocompatible triggering solution. The adhesion of the bioadhesive relies on the removal of interfacial water from the tissue surface, followed by physical and covalent cross-linking with the tissue surface. The triggerable detachment of the bioadhesive results from the cleavage of bioadhesive’s cross-links with the tissue surface by the triggering solution. After it is adhered to wet tissues, the bioadhesive becomes a tough hydrogel with mechanical compliance and stretchability comparable with those of soft tissues. We validate in vivo biocompatibility of the bioadhesive and the triggering solution in a rat model and demonstrate potential applications of the bioadhesive with triggerable benign detachment in ex vivo porcine models.

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Più fonti

Tesi sul tema "Interfacial tissues"

Massafra, Gabriele. "Electrospun scaffolds for regeneration of musculoskeletal interface tissues". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/21485/.

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L’apparato muscolo scheletrico è composto da strutture muscolari, articolari e ossee. Tali tessuti sono molto diversi tra loro e hanno proprietà meccaniche estremamente variabili, pertanto presentano una transizione graduale in corrispondenza della loro giunzione, onde evitare l’insorgere di concentrazioni di tensione. L’evoluzione ha portato alla formazione di particolari interfacce che permettono la corretta trasmissione dei carichi distribuendo le tensioni su una superficie più ampia in corrispondenza della giunzione. Le interfacce che vanno a inserirsi nell’osso vengono definite entesi e in particolare, in questa review, analizzeremo il caso di quelle tra tendini/legamenti e osso. In questo lavoro ci siamo anche concentrati sulla giunzione miotendinea, ovvero tra muscolo e tendine. Sono numerose le lesioni che riguardano muscoli, ossa, tendini o legamenti e molto spesso l’infortunio avviene a livello della giunzione. Quando ciò accade vi sono diverse strade, ciascuna con i suoi vantaggi e svantaggi: sutura, autograft, allograft o xenograft. Oltre a queste soluzioni si è fatta gradualmente più spazio la possibilità di realizzare degli scaffold che vadano temporaneamente a sostituire la parte danneggiata e a promuovere la sua rigenerazione, degradandosi man mano. L’elettrofilatura (Elettrospinning) è un processo produttivo che negli ultimi decenni si è affermato come tecnica per la fabbricazione di questi scaffold, fino a diventare uno tra i principali processi utilizzati dai ricercatori in questo campo. Questa tecnica infatti permette di realizzare scaffold di nanofibre porose utilizzando polimeri biodegradabili e soprattutto biocompatibili. Lo scopo della review è proprio quello di scoprire tutti i lavori e gli studi che utilizzano l’elettrofilatura per realizzare degli scaffold per interfacce, delineando così lo stato dell’arte sui progressi fatti e sulle varie tecniche utilizzate.

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Aliee, Maryam. "Dynamics and mechanics of compartment boundaries in developing tissues". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-113236.

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During development of tissues, cells collectively organize to form complex patterns and morphologies. A general feature of many developing epithelia is their distinct organization into cellular compartments of different cell lineages. The interfaces between these compartments, called compartment boundaries, maintain straight and sharp morphologies. The interfaces play key roles in tissue development and pattern formation. An important model system to study the morphology of compartment boundaries during development is the wing disc of the fruit fly. Two compartment boundaries exist in the fly wing disc, the anteroposterior (AP) boundary and the dorsoventral (DV) boundary. A crucial question is how compartment boundaries are shaped and remain stable during growth. In this work, we discuss the dynamics and mechanisms of compartment boundaries in developing epithelia. We analyze the general features of interfacial phenomena in coarse- grained models of passive and active fluids. We introduce a continuum description of tissues with two cell types. This model allows us to study the propagation of interfaces due to the interplay of cell dynamics and tissue mechanics. We also use a vertex model to describe cellular compartments in growing epithelia. The vertex model accounts for cell mechanics and describes a 2D picture of tissues where the network of adherens junctions characterizes cell shapes. We use this model to study the general physical mechanisms by which compartment boundaries are shaped. We quantify the stresses in the cellular network and discuss how cell mechanics and growth influence the stress profile. With the help of the anisotropic stress profile near the interfaces we calculate the interfacial tension. We show that cell area pressure, cell proliferation rate, orientation of cell division, cell elongation created by external stress, and cell bond tension all have distinct effects on the morphology of interfaces during tissue growth. Furthermore, we investigate how much different mechanisms contribute to the effective interfacial tension. We study the mechanisms shaping the DV boundary in wing imaginal disc at different stages during the development. We analyze the images of wing discs to quantify the roughness of the DV boundary and average cell elongation in its vicinity. We quantify increased cell bond tension along the boundary and analyze the role of localized reduction in cell proliferation on the morphology of the DV boundary. We use experimentally determined values for cell bond tension, cell elongation and bias in orientation of cell division in simulations of tissue growth in order to reproduce the main features of the time-evolution of the DV boundary shape.

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Woodfield, Timothy Bryan Francis. "Interfacial shear strength criteria for tissue-engineered cartilage anchored to porous synthetic scaffolds". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0019/MQ49768.pdf.

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Revell, Christopher. "Modelling physical mechanisms driving tissue self-organisation in the early mammalian embryo". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276833.

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Abstract (sommario):

In the mammalian embryo, between 3.5 and 4.5 days after fertilisation, the cells of the inner cell mass evolve from a uniform aggregate to an ordered structure with two distinct tissue layers - the primitive endoderm and epiblast. It was originally assumed that cells differentiated to form these layers in situ, but more recent evidence suggests that both cell types arise scattered throughout the inner cell mass, and it is thus proposed that the tissue layers self-organise by physical mechanisms after the specification of the two cell types. We have developed a computational model based on the subcellular element method to combine theoretical and experimental work and elucidate the mechanisms that drive this self-organisation. The subcellular element method models each cell as a cloud of infinitesimal points that interact with their nearest neighbours by local forces. Our method is built around the introduction of a tensile cortex in each cell by identifying boundary elements and using a Delaunay triangulation to define a network of forces that act within this boundary layer. Once the cortex has been established, we allow the tension in the network to vary locally at interfaces, modelling the exclusion of myosin at cell-cell interfaces and consequent reduction in tension. The model is validated by testing the simulated interfaces in cell doublets and comparing to experimental data and previous theoretical work. Furthermore, we introduce dynamic tension to model blebbing in primitive endoderm cells. We investigate the effects of cortical tension, differential interfacial tension, and blebbing on interfaces, rearrangement, and sorting. By establishing quantitative measurements of sorting we produce phase diagrams of sorting magnitude given system parameters and find that robust sorting in a 30 cell aggregate is best achieved by a combination of differential interfacial tension and blebbing.

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Simmons, Craig Alexander. "Modelling and characterization of mechanically regulated tissue formation around bone-interfacing implants". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0022/NQ49943.pdf.

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Beguinel, Johanna. "Interfacial adhesion in continuous fiber reinforced thermoplastic composites : from micro-scale to macro-scale". Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI051.

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L’intérêt croissant de l’industrie pour les matériaux composites thermoplastiques est motivé par leurs propriétés de thermoformabilité, de recyclabilité ainsi que leurs capacités de cadences de production élevées. Le développement de matériaux pré-imprégnés thermoplastiques, apparus dès les années 1980, s’est imposé comme un moyen efficace de contourner les fortes viscosités des polymères utilisés en réduisant la distance d’écoulement des polymères à l’état « fondu ». Cette étude s’est plus particulièrement intéressée au développement de composites à base de tissus de verre et de carbone pré-imprégnés par un latex acrylique, le TPREG I. En outre, les propriétés mécaniques élevées des matrices acryliques, alliées à un coût relativement faible, en font un matériau intéressant, de nature à permettre un saut technologique dans la conception et la fabrication de composites structuraux à matrice organique. Notre étude s’est concentrée sur la mesure de l’adhésion à l’interface fibre/matrice acrylique car cette région est au cœur du transfert de charge de la matrice vers les fibres et conditionne donc les propriétés mécaniques du composite. Nous avons choisi d’évaluer l’adhésion interfaciale en combinant des analyses de mouilllage avec des tests mécaniques aux échelles microscopique et macroscopique. Le test micromécanique de la microgoutte permet de mettre en évidence le rôle central de l’ensimage des fibres sur la contrainte de cisaillement interfaciale. L’adhésion thermodynamique, déterminé par des mesures d’énergie de surface, est en accord avec la contrainte de cisaillement et souligne l’influence de la polarité de l’ensimage. A l’échelle macroscopique, les essais de traction hors-axe sur composites unidirectionnels permettant de solliciter l’interface en cisaillement quasi-plan ont mis en exergue une corrélation entre les échelles micro et macro. L’étude a également permis de dégager une forte augmentation de l’adhésion grâce à une modification de la matrice acrylique, ainsi qu’une dégradation des propriétés interfaciales à l’échelle micro par vieillissement hydrolytique. Cette étude constitue une première base de données concernant les propriétés interfaciales de composites thermoplastiques acryliques et démontre l’importance d’une étude multi-échelles dans la conception de nouveaux composites
The present study was initiated by the development of a new processing route, i.e. latex-dip impregnation, for thermoplastic (TP) acrylic semi-finished materials. The composites resulting from thermocompression of TPREG I plies were studied by focusing of interfacial adhesion. Indeed the fiber/matrix interface governs the stress transfer from matrix to fibers. Thus, a multi-scale analysis of acrylic matrix/fiber interfaces was conducted by considering microcomposites, as models for fiber-based composites, and unidirectional (UD)macro-composites. The study displayed various types of sized glass and carbon fibers. On one hand, the correlation between thermodynamic adhesion and practical adhesion, resulting from micromechanical testing, is discussed by highlighting the role of the physico-chemistry of the created interphase. Wetting and thermodynamical adhesion are driven by the polarity of the film former of the sizing. On the other hand, in-plane shear modulus values from off-axis tensile test results on UD composites are consistent with the quantitative analyses of the interfacial shear strength obtained from microcomposites. More specifically, both tests have enabled a differentiation of interface properties based on the fiber sizing nature for glass and carbon fiber-reinforced (micro-)composites. The study of overall mechanical and interface properties of glass and carbon fiber/acrylic composites revealed the need for tailoring interfacial adhesion. Modifications of the matrix led to successful increases of interfacial adhesion in glass fiber/acrylic composites. An additional hygrothermal ageing study evidenced a significant loss of interfacial shear strength at micro-scale which was not observed for UD composites. The results of this study are a first step towards a database of relevant interface properties of structural TP composites. Finally, the analyses of interfaces/phases at different scales demonstrate the importance of a multi-scale approach to tailor the final properties of composite parts

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Schröder, Sven [Verfasser], Roland [Akademischer Betreuer] Thewes, Roland [Gutachter] Thewes, Stefano [Gutachter] Vassanelli e Venuto Daniela [Gutachter] De. "A system for purely capacitive in-vivo neural tissue interfacing with high spatiotemporal resolution / Sven Schröder ; Gutachter: Roland Thewes, Stefano Vassanelli, Daniela De Venuto ; Betreuer: Roland Thewes". Berlin : Technische Universität Berlin, 2016. http://d-nb.info/1156184894/34.

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Narayanan, Amal. "Physicochemical Cues for the Design of Underwater Adhesives". University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1616164088200956.

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Gonçalves, Raquel Maria da Costa. "One-step all-aqueous fabrication of tubular pre-endothelized structures". Master's thesis, 2021. http://hdl.handle.net/10773/31021.

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Abstract (sommario):

Blood vessels are one of the most important constituents of the human body. They are responsible for maintaining tissue function and survival by providing oxygen and nutrients, as well as to provide essential molecules and biochemical signaling during tissue development and regeneration, which depend on the formation of new vascular structures. The ability to develop in vitro hollow and tubular structures capable of supporting cell functionality and mimicking biological architectures of native tissues such as blood vessels have the potential to foster scientific and technological advances in the fields of tissue engineering and regenerative medicine. Classical methods to fabricate self-sustained tubular structures are normally dependent on pre- and post-processing steps, or complex and non straightforward techniques, often incompatible with the fabrication of free-form architectures. The generation of tubular fiber-shaped materials through methods that allow their direct fabrication and their deposition in versatile shapes and directions in a spatial- and size-controlled manner may be key to overcome some of those limitations. Aqueous two-phase systems (ATPS), which behave as fully aqueous emulsions, have started to be recently explored in the biomedical field. Those are mostly used as templates for the generation of sophisticated biomaterials. Interfacial complexation of oppositely charged polyelectrolytes has been exploited as a valuable strategy for the production of materials using template ATPS. Most studies in the literature have focused at the fabrication of spherical shaped materials for the encapsulation of bioactive and delicate cargos. However, the production of fiber materials with a tubular structure by this strategy has been poorly explored, and its ability to allow cell encapsulation, viability and long-term culture has not been yet reported. In this project, we purpose a rapid strategy to fabricate hollow fiber-shaped materials in a full aqueous environment stabilized by an interfacial membrane resultant from the complexation of two naturally-derived oppositely charged polyelectrolytes. Simple straight or branched structures amenable to be perfused with liquids could be produced, and tubular features of the structures could be confirmed by scanning electron microscopy. The stability of the fabricated material was dependent on polyelectrolytes’ concentration, complexation time, and on the system’s pH. In addition, the mechanical properties and swelling behavior of the fibers could be tuned by complexation time, and their diameter could be tailored from millimeters to the micrometer scale. Encapsulation of human stem cells derived from adipose tissue (hASCs) demonstrated the ability of the system to withstand cell viability and adhesion up to 7 days, in systems containing cell adhesion sequences. Heterotypic fibers containing hASCs in co-culture with human umbilical vein endothelial cells (HUVECs) enabled endothelial cell survival for at least 14 days, which was confirmed by immunocytochemistry. This work may represent relevant advances on the easy and one-step fabrication of biomaterial-based structures with the ability to resemble native tubular tissues with biological relevance.
Os vasos sanguíneos são um dos constituintes mais importantes do corpo humano. São responsáveis por manter a função e sobrevivência dos tecidos, fornecendo oxigénio e nutrientes, bem como por fornecer moléculas essenciais e sinalização bioquímica durante os processos de desenvolvimento e regeneração dos tecidos que dependem da formação de novas estruturas vasculares. A capacidade de desenvolver estruturas ocas e tubulares in vitro que visam apoiar a função celular e recriar arquiteturas biológicas de tecidos nativos, como vasos sanguíneos, têm potencial de promover avanços científicos e tecnológicos nas áreas de engenharia de tecidos e medicina regenerativa. Os métodos clássicos para fabricar estruturas tubulares são frequentemente dependentes de pré- e pós-processamento ou de técnicas complexas que por vezes não são facilmente implementáveis, muitas vezes incompatíveis com arquiteturas de forma livre. A criação de materiais tubulares em forma de fibra através de métodos que permitem a sua fabricação direta e a sua deposição em formas e direções versáteis de uma maneira espacialmente controlada e tamanho controlado, pode ser a chave para superar algumas dessas limitações. Os sistemas bifásicos aquosos (ATPS), que se comportam como emulsões totalmente aquosas, começaram a ser explorados recentemente no campo biomedicina. Esses são usados principalmente como modelos para a geração de biomateriais sofisticados. A complexação interfacial de polieletrólitos de carga oposta tem sido explorada como uma estratégia valiosa para a produção de materiais usando o modelo ATPS. A maioria dos estudos na literatura tem se concentrado na fabricação de materiais de formato esférico para o encapsulamento de cargas bioativas e delicadas. No entanto, a produção de materiais fibrosos com estrutura tubular por esta estratégia tem sido pouco explorada, e sua capacidade de permitir o encapsulamento celular, viabilidade e cultura a longo prazo ainda não foi reportada. Neste projeto, propomos uma estratégia rápida para fabricar materiais em forma de fibra oca num ambiente totalmente aquoso estabilizado por uma membrana interfacial resultante da complexação de dois polieletrólitos de origem natural e de carga oposta. Estruturas simples ou ramificadas capazes de suportar a perfusão de liquidos foram produzidas, na qual as suas caracteristicas tubulares poderam ser confirmadas por microscopia eletrónica de varrimento. A estabilidade do biomaterial mostrou-se dependente da concentração dos polieletrólitos e do tempo de complexação, bem como do pH do sistema. Além disso, as propriedades mecânicas e comportamento de swelling puderam ser ajustadas pelo tempo de complexação, e o seu tamanho foi definido compreendendo diâmetros que variam de escalas milimétricas a micrométricas. O encapsulamento de células-tronco humanas derivadas do tecido adiposo (hASCs) demonstrou a capacidade de suportar a viabilidade e adesão celular até 7 dias, em sistemas contendo sequências adesivas. Fibras heterotipicas contendo hASCs em co-cultura com células endoteliais da veia umbilical humana (HUVECs) contribuiram para a sobrevivência das células endoteliais por pelo menos 14 dias, confirmado por imunocitoquímica. Este trabalho pode representar avanços relevantes na fabricação fácil e em apenas um passo de biomateriais com a capacidade mimetizar tecidos tubulares nativos com relevância biológica.
Mestrado em Biotecnologia

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Libri sul tema "Interfacial tissues"

Woodfield, Timothy Bryan Francis. Interfacial shear strength criteria for tissue-engineered cartilage anchored to porous synthetic scaffolds. Ottawa: National Library of Canada, 2000.

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Dental Hard Tissues and Bonding: Interfacial Phenomena and Related Properties. Springer, 2005.

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Eliades, George, Theodore Eliades e David C. Watts. Dental Hard Tissues and Bonding: Interfacial Phenomena and Related Properties. Springer, 2014.

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George, Eliades, Watts D. C e Eliades Theodore, a cura di. Dental hard tissues and bonding: Interfacial phenomena and related properties. Berlin: Springer, 2005.

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Material-Tissue Interfacial Phenomena. Elsevier, 2017. http://dx.doi.org/10.1016/c2014-0-03726-4.

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Misra, Anil, e Paulette Spencer. Material-Tissue Interfacial Phenomena: Contributions from Dental and Craniofacial Reconstructions. Elsevier Science & Technology, 2016.

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Simmons, Craig Alexander. Modelling and characterization of mechanically regulated tissue formation around bone-interfacing implants. 2000.

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-O, Glantz P., Leach S. A, Ericson Thorild 1929- e Research Group on Surface and Colloid Phenomena in the Oral Cavity., a cura di. Oral interfacial reactions of bone, soft tissue, and saliva: Proceedings of a workshop, November 9-11, 1984, Marstrand, Sweden. Oxford: IRL Press, 1985.

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Capitoli di libri sul tema "Interfacial tissues"

Ghosal, Krishanu, Rohit Khanna e Kishor Sarkar. "Biopolymer Based Interfacial Tissue Engineering for Arthritis". In Orthopedic Biomaterials, 67–88. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-89542-0_4.

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Elnaggar, Mahmoud A., e Yoon Ki Joung. "Tissue-Inspired Interfacial Coatings for Regenerative Medicine". In Advances in Experimental Medicine and Biology, 415–20. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0947-2_22.

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Park, Joon B., e Roderic S. Lakes. "Soft Tissue Replacement II: Blood-Interfacing Implants". In Biomaterials, 265–91. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-2156-0_12.

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Athanassiou, Athanassia, Despina Fragouli, Ilker Bayer, Paolo Netti, Loris Rizzello e Pier Paolo Pompa. "Soft Matter Composites Interfacing with Biomolecules, Cells, and Tissues". In Bioinspired Approaches for Human-Centric Technologies, 29–76. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-04924-3_2.

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Kwiat, Moria, e Fernando Patolsky. "2 Interfacing Biomolecules, Cells and Tissues with Nanowire-based Electrical Devices". In Modern Aspects of Electrochemistry, 67–104. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-1-4614-2137-5_2.

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Tian, Bozhi. "Nanowire Field-Effect Transistors for Electrical Interfacing with Cells and Tissue". In One-Dimensional Nanostructures, 515–29. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118310342.ch25.

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Tayebi, Lobat, Reza Masaeli e Kavosh Zandsalimi. "Application of 3D Printing in Reconstruction of Oral and Maxillofacial Multi- and Interfacial Tissue Defects". In 3D Printing in Oral & Maxillofacial Surgery, 167–217. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-77787-6_7.

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"Water Associated with Bio-Objects: Cells and Tissues". In Nuclear Magnetic Resonance Studies of Interfacial Phenomena, 806–905. CRC Press, 2013. http://dx.doi.org/10.1201/b14202-12.

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"Adhesion of Cells and Tissues to Bioabsorbable Polymeric Materials: Scaffolds, Surgical Tissue Adhesives and Anti-adhesive Materials". In Surface and Interfacial Aspects of Cell Adhesion, 485–504. CRC Press, 2011. http://dx.doi.org/10.1201/b12179-30.

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Huang, Yixian, Jingjing Sun e Song Li. "Rational Design of Polymeric Micelle for Cancer Therapy". In Advances in Medical Technologies and Clinical Practice, 311–36. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-0751-2.ch012.

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Abstract (sommario):

Clinical application of anticancer drugs is limited by problems such as low water solubility, lack of tissue-specificity and toxicity. Formulation development represents an important approach to these problems. Among the many delivery systems studied, polymeric micelles are an attractive nano-scaled delivery system due to their simplicity, ability to solubilize water-insoluble drugs, and small size (10-100 nm) that can take advantage of enhanced permeability and retention effect to specifically accumulate in tumors. This book chapter provides a brief review of recent advancements in developing environmentally responsive micellar systems for controlled delivery of chemotherapeutic agents to tumor tissues. The emphasis is placed on the discussion of several dual functional nanomicellar systems that were recently developed in our laboratory as well as a new strategy of improving micellar formulations via incorporation of an interfacial drug-interactive motif(s).

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Atti di convegni sul tema "Interfacial tissues"

Pan, Yi, Assimina A. Pelegri e David I. Shreiber. "Emulating the Interfacial Kinematics of CNS White Matter With Finite Element Techniques". In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53579.

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Axonal injury represents a critical target for TBI and SCI prevention and treatment. Mechanical strain has been identified as the proximal cause of axonal injury, while secondary ischaemic and excitotoxic insults associated with the primary trauma potentially exacerbate the structural and functional damage. Many studies have been attempted to identify the states of stress and strain in white matter using animal and finite element models. These material models employed in finite element simulations of the central nervous system (CNS) of soft tissues heavily depend on phenomenological representations. The accuracy of these simulations depends not only on correct determination of the material properties but also on precise depiction of the tissues’ microstructure.

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Devaprakasam, D. "Nature Nanocomposite Versus Man-Made Nanocomposites: Studies of Nanoscale Structural, Chemical and Mechanical Hierarchy of a Fish Scale in Contrast With Man-Made Polymer Nanocomposites". In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93085.

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Hierarchical designs of biological structures have remarkable physical, chemical mechanical and biological properties and functionalities over the wide range of length scales [1–4]. Man-made nanocomposites have dramatic improvement of the structural and mechanical properties but however they have very limited hierarchy [5]. Fish scales are bone-like tissues, which form a protective layer on the body of the fish and enable the fish to swim efficiently. Bones and bone-like parts in living organism are formed as tissues by self-assembly of bio-minerals and protein matrix. These tissues are bio-nanocomposites and have hierarchical structure ranging from nanoscale to macroscale [2–4]. Bio-hierarchy contains different bio-macromolecules, bio-minerals, interfacial bonds and porosity which result in gradient mechanical properties at multiple length scales [1–6]. Fish scale consists of inorganic bio-minerals and organic collagens [3,4]. Multilevel hierarchy influences elasticity, hardness and fracture toughness of fish scale. They have additional functions related to movement including reduction or increase of drag [7] and rapid manoeuvre while they are hunting or avoiding predators. In this article we report comparison studies of hierarchical nanocomposite of sardina pilchardus(sp) fish scale and man-made SiO2 nanoparticles filled nanocomposites.

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Khandaker, M. P. H., Yanling Li e Stefano Tarantini. "Interfacial Fracture Strength Measurement of Tissue-Biomaterial Systems". In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65038.

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The interfacial mechanics at the bone-implant interface is a critical issue for implant fixation and the filling of bone defects created by tumors and/or their excision. The present study is based on the hypothesis that the differences of the surface roughness at bone/ implant interface due to incorporation of micro and nano nanoparticle additives may have significant influence on the quality of bone/implant union. This research studied poly Methyl MethAcrylate (PMMA) bone cement with and without MgO additives as different implant materials. The aims of this research were to determine the influences of a magnesium oxide (MgO) additive particle size to PMMA bone cement on the bonding strength between bone and bone cement specimens. The scope of work for this study were: (1) to quantify elastic properties (Young’s modulus and Poisson’s ratio) of bone cement specimens, (2) to determine whether inclusion of MgO particles with PMMA has any influence on the interface strength between bone and PMMA, and (3) to quantify the effect of surface roughness on the interface fracture strength between bone and PMMA. This study found that the mean interface strength for bone-PMMA is significantly less than the mean interface strengths of bone-PMMA with microsize MgO particles and bone-PMMA with nanosize MgO particles.

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Paietta, Rachel C., Evalina Burger e Virginia L. Ferguson. "Material Properties of the Developing Bone-Cartilage Interface in the Human Fetal Spine". In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53774.

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Treatment of disc degeneration and subsequent device interfacing in the spine are limited by a poor understanding of the mechanics of the bone-cartilage interface between vertebral bodies (VB) and the intervertebral disc (IVD). Additionally, tissue engineering strategies are under investigation despite a lack of information on the structure of the developing interface and mechanical properties during endochondral ossification. Fetal tissue provides an initial reference to study the developing mineralization patterns and mechanical property gradient at the transition between mineralized and soft tissues. Through nanoindentation, quantitative back scattered electron microscopy (qBSE) (Ferguson 2003) and energy-dispersive X-ray spectroscopy (EDX), it is possible to study mineralized tissue formation from both mechanical and compositional perspectives at scales relevant to the mechanics of the interface.

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Liu, Y. X., S. Thomopoulos, V. Birman, J. S. Li e G. M. Genin. "Bi-Material Attachment Through a Soft Tissue Interfacial System". In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19560.

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Connecting dissimilar materials is a fundamental challenge because of stress concentrations that can arise at their interface. “Functionally graded” material systems that interpolate spatially between properties of two materials are often considered to reduce stress concentrations in engineering and medical applications.

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Sarkar, Romit, Rusha Banerjee, Ghodrat Karami e Fardad Azarmi. "Micromechanical Model for Examination and Characterization of Interfacial Response of Fibrous Composites". In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39984.

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A micromechanical model for a Representative Volume Element (RVE) of a composite material to study the interface adhesion is introduced. The composite constituents assumed to have elastic properties with unidirectional fiber arrangement. The characterization is performed to study the interface and the separation/delamination of layers and their impacts on the overall mechanical response and properties of the composite material. Finite element package ANSYS is used to simulate the conditions of the interface employing cohesive zone modeling. The impact of an increasing axial transverse loading force on the interface in terms of its separation is studied. The exponential traction-separation curve pioneered by Xu and Needleman [1] will be implemented. The RVE is periodically constrained to represent a common element within the continuum domain far from the locality influence of the force and for a homogenized mechanical behavior study of the interface. The examination of the characteristics of the cohesive zone element as a simulation tool for interface analysis gives us conditions of a closer simulation for tissue engineering analysis.

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Katti, Kalpana S., Devendra Verma, Rahul Bhowmik e Dinesh R. Katti. "Bioactivity and Mechanical Behavior of Polymer-Hydroxyapatite Composite Biomaterials for Bone Tissue Engineering". In ASME 2006 International Manufacturing Science and Engineering Conference. ASMEDC, 2006. http://dx.doi.org/10.1115/msec2006-21051.

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Achieving optimal mechanical strength of scaffolds is the key issue in bone tissue engineering. We describe a biomimetic route for design of composites of polymers (polyacrylic acid (PAAc) and polycaprolactone (PCL)) and hydroxyapatite (HAP). The mineral polymer interfaces have a significant role on mechanical behavior as well as bioactivity of the composite systems. We have used a combination of experimental (photoacoustic infrared spectroscopy) as well as modeling (molecular dynamics) techniques to evaluate the nature of interfaces in the composites. Porous composite scaffolds of in situ HAP with PCL are made. Our simulation studies indicate calcium bridging between COO− of PAAc and surface calcium of HAP as well as hydrogen bonding. These results are also supported by infrared spectroscopic studies. PAAc modified surfaces of in situ HAP influence the microstructure and mechanical response of porous composites. Significant differences are present in the mechanical response of in situ and ex situ composite scaffolds. In addition, the growth and mechanism of apatite growth in the in situ and ex situ composites is different. Bioactivity is measured by soaking composite scaffolds in simulated body fluid (SBF). Apatite growth in ex situ composites is primarily by heterogeneous nucleation and that in in situ is primarily by homogeneous nucleation. We also observe that apatite grown on in situ HAP/PCL composites from SBF exhibits higher elastic modulus and hardness. Thus, by influencing the interfacial behavior in bone biomaterials both mechanical response and bioactivity of the composite systems may be modified. The present study gives insight into the interfacial mechanisms responsible for mechanical response as well as bioactivity in biomaterials.

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Cheng, Gary J., e Chang Ye. "Experiment, Thermal Simulation and Characterizations on Transmission Laser Coating of Hydroxyapatite on Metal Implant". In ASME 2008 International Manufacturing Science and Engineering Conference collocated with the 3rd JSME/ASME International Conference on Materials and Processing. ASMEDC, 2008. http://dx.doi.org/10.1115/msec_icmp2008-72290.

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Coating of bioceramic material — Hydroxyapatite (HAp) — on metal implant has attracted many attentions in biomedical industry recently because its combination of good mechanical property and biocompatibility. However, most of current HAp coatings are lack of coating/substrate interfacial strength, and/or biocompatibility. The cell-tissue attachment is affected by the degraded biocompatibility due to decomposition of HAp during high temperature processing. In this paper, an innovative method — transmission laser coating is investigated to coat HAp on Ti substrate with low temperature processing. This process enhances the HAp/Metal interfacial property of current coatings, while maintaining good biocompatibility. Experiments are conducted using a continuous Nd-YAG laser. Multiphysics simulation is conducted to simulate the temperature distribution in coatings and substrates during TLC processing. X-ray energy dispersion spectrum is used to measure the chemical composition of HAp coatings after TLC process. Pull-out tests are conducted to measure the interfacial strength between the HAp coating and Ti substrate. Cell culture study is conducted to qualitatively evaluate the biocompatibility after TLC of HAp particles. These results show that TLC processing will open new ways of producing biocompatible bioceramic coatings with controlled thickness, and at low processing temperature.

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Chahine, Nadeen O., Nicole M. Collette, Heather Thompson e Gabriela G. Loots. "Application of Carbon Nanotubes in Cartilage Tissue Engineering". In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192494.

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Carbon nanotubes (CNTs) are cylindrical allotropes of carbon that are nanometers in diameter and posses unique physical properties, positioning them as ideal materials for studying physiology at a single cell level. CNTs have the potential to become a very important component of medical therapeutics, likely acting as (a) drug delivery system [1], (b) existing as an interfacial layer in surgical implants [2,3], or (c) acting as scaffolding in tissue engineering [4,8]. While some studies have explored the use of CNTs as a novel material in regenerative medicine, they have not yet been fully evaluated in cellular systems. One major limitation of CNTs that must be overcome is their inherent cytotoxicity. The goal of this study is to assess the long-term biocompatibility of CNTs for chondrocyte growth. We hypothesize that CNT-based material in tissue engineering can provide an improved molecular sized substrate for stimulation of cellular growth, and structural reinforcement of the scaffold mechanical properties. Here we present data on the effects of CNTs on chondrocyte viability and biochemical deposition examined in composite materials of hydrogels + CNTs mixtures. Also, the effects of CNTs surface functionalization with polyethlyne glycol (PEG) or carboxyl groups (COOH) were examined.

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Brahmbhatt, Khushboo, Wujun Zhao, Zhaojie Deng, Leidong Mao e Eric Freeman. "Magnetically Responsive Droplet Interface Bilayer Networks". In ASME 2015 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/smasis2015-9029.

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This work explores incorporating ferrofluids with droplet interface bilayer (DIB) membranes. Ferrofluids contain magnetic nanoparticles in solution with a stabilizing surfactant, providing a magnetically-responsive fluid. These fluids allow for remote mechanical manipulation of ferrofluid droplets through magnetic fields, and will allow for better control over the characteristics of networks of stimuli-responsive cellular membranes created through by DIB technique. This work involves several phases. First, a suitable biocompatible ferrofluid is synthesized, containing a neutral pH and a biocompatible surfactant. Once a proper ferrofluid is identified, it is tested as the aqueous phase for the creation of DIB membranes. Interfacial membranes between ferrofluid droplets are created and compared to non-ferrofluid DIB membranes. The interfacial membrane between two ferrofluid droplets was tested for leakage and stability, and the electrical characteristics of the interfacial membrane were studied and compared to non-ferrofluid DIB membranes. Once it is confirmed that the ferrofluid droplets do not negatively interfere with the formation of the artificial cellular membranes through the electrical measurements, the magnetically-responsive nature of the ferrofluid droplets are used to form large networks of DIB membranes through a simple magnetic field. These networks are easy to assemble and may be remotely manipulated, providing a significant step towards the rapid and simple assembly of DIB networks advancing towards the tissue scale.

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