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Letteratura scientifica selezionata sul tema "Isoquinoline"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Isoquinoline"

1

Mandrekar, Ketan S., and Santosh G. Tilve. "P₄O₁₀/TfOH mediated domino condensation–cyclization of amines with diacids: a route to indolizidine alkaloids under catalyst- and solvent-free conditions." RSC Advances 12, no. 28 (2022): 17701–5. http://dx.doi.org/10.1039/d2ra02534e.

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A highly efficient and direct methodology for the construction of pyrrolo[2,1-a]isoquinoline, pyrido[2,1-a]isoquinoline, and 12b-H and 12b-OH isoindolo[2,1-a]isoquinolinone alkaloids from commercially available synthons is devised.

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2

Yang, Chunmei, Guoqing Zhang, Senling Tang, Yang Pan, Huawu Shao, and Wei Jiao. "Dess–Martin Periodinane-Mediated Oxidative Coupling Reaction of Isoquinoline with Benzyl Bromide." Molecules 28, no. 3 (2023): 923. http://dx.doi.org/10.3390/molecules28030923.

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Dess–Martin periodinane (DMP) is a broadly applicable oxidant in chemical synthesis. In this work, an efficient and convenient synthesis of N-substituted isoquinolinone derivatives mediated by DMP was achieved through the oxidative coupling reaction of functionalized isoquinoline with readily available benzyl bromide, which is a metal-free, mild, and practical method for synthesizing isoquinoline-1,3-dione or isoquinoline-1,3,4-trione derivatives in excellent yields. The H2O18-labeling experiment was performed to gain insight into the possible mechanism for this reaction.

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3

Koketsu, Mamoru, Amol Sonawane, Yunnus Shaikh, and Dinesh Garud. "Synthesis of Isoquinoline-Fused Quinazolinones through Ag(I)-Catalyzed Cascade Annulation of 2-Aminobenzamides and 2-Alkynylbenzaldehydes." Synthesis 51, no. 02 (2018): 500–507. http://dx.doi.org/10.1055/s-0037-1610910.

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A new route for the expedient synthesis of a specific regioisomer of isoquinoline-fused quinazolinones is reported. Silver(I)-catalyzed cascade cyclization of 2-aminobenzamides and 2-alkynylbenzaldehydes followed by in situ oxidation gives 12-butyl- or 12-aryl-6H-isoquinolino[2,1-a]quinazolin-6-ones in 69–91% yields. The structure of the isoquinoline-fused quinazolinone was confirmed by X-ray crystallography analysis.

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4

Gouda, Moustafa A., Hanan I. Althagbi, Nourah A. Al Zahrani, Ameen A. Abu-Hashem, Tahah A. Ameen, and Alshymaa Z. Al-Mokadem. "Synthesis, reactions and applications of pyrimido[2,1-a]isoquinolines derived from 1, 2-difunctionalized pyrimidine derivatives (Part V)." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 01 (2025): 1. https://doi.org/10.59467/ijhc.2025.35.1.

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Pyrimido[2,1-a]isoquinolines (Py-[2,1-a]isoQs) are a class of heterocyclic compounds that have gained significant attention in the fields of organic chemistry, medicinal chemistry, and materials science. (Py-[2,1-a]isoQs) consist of a pyrimidine ring fused to an isoquinoline ring. This unique structure imparts distinct electronic and steric properties, making them attractive for various applications. They have been explored as potential therapeutic agents for treating cancer, and infectious diseases; their planar structure and conjugation make them suitable for applications in organic electron

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5

Zhang, Lujun, Wenfang Xiong, Biao Yao, et al. "Facile synthesis of isoquinolines and isoquinoline N-oxides via a copper-catalyzed intramolecular cyclization in water." RSC Advances 12, no. 47 (2022): 30248–52. http://dx.doi.org/10.1039/d2ra06097c.

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6

Murtagh, Kevin, Brian A. Sweetman, and Patrick J. Guiry. "New chiral tridentate ligands for asymmetric catalysis." Pure and Applied Chemistry 78, no. 2 (2006): 311–20. http://dx.doi.org/10.1351/pac200678020311.

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The synthesis of new tridentate, isoquinoline-derived ligands, involving successive Suzuki cross-coupling reactions, is described. We were able to resolve 1-[3-(2-hydroxy-phenyl)-isoquinolin-1-yl]-naphthalen-2-ol via molecular complexation with N-benzylcinchonidinium chloride, whereas 1,3-bis(2-hydroxy-naphthalen-1-yl)-isoquinoline was resolved by chromatographic separation of its epimeric camphorsulfonates. Their barrier to rotation about the central biaryl axis was evaluated via racemization studies. Application of enantiopure 1,3-bis(2-hydroxynaphthalen-1-yl)-isoquinoline in the addition of

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7

Wu, Wei, Yan Wang, Jing Guo та ін. "Asymmetric acyl-Mannich reaction of isoquinolines with α-(diazomethyl)phosphonate and diazoacetate catalyzed by chiral Brønsted acids". Chemical Communications 56, № 76 (2020): 11235–38. http://dx.doi.org/10.1039/d0cc03201h.

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8

Sloop, Joseph C. "Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress." Journal of Chemistry 2017 (2017): 1–15. http://dx.doi.org/10.1155/2017/2860123.

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Heterocyclic molecules incorporating fluorinated isoquinoline components are found in many medicinally and agriculturally important bioactive products as well as industrially impactful materials. Within the past decade, a variety of isoquinolinic ring assembly techniques has enabled the introduction of diverse fluorine-containing functionalities which can enhance potential bioactivity and industrial utility. This review examines recent noncatalyzed and transition metal catalyzed synthetic approaches to the assembly of isoquinoline derivatives that are ring-fluorinated and/or result in the inco

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9

Li, Jiu-ling, Wei-ze Li, Ying-chun Wang, Qiu Ren, Heng-shan Wang, and Ying-ming Pan. "Palladium(ii)-catalyzed C–C and C–O bond formation for the synthesis of C1-benzoyl isoquinolines from isoquinoline N-oxides and nitroalkenes." Chemical Communications 52, no. 65 (2016): 10028–31. http://dx.doi.org/10.1039/c6cc03530b.

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10

An, Yuanyuan, Hongguang Xia, and Jie Wu. "Base-controlled [3+3] cycloaddition of isoquinoline N-oxides with azaoxyallyl cations." Chemical Communications 52, no. 68 (2016): 10415–18. http://dx.doi.org/10.1039/c6cc03650c.

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Abstract (sommario):

A base-controlled [3+3] cycloaddition reaction of isoquinoline N-oxides with azaoxyallyl cations is developed, leading to 1,11b-dihydro-[1,2,4]oxadiazino[3,2-a]isoquinolin-2(3H)-ones and 2-(isoquinolin-1-yloxy)acetamides, respectively. This transformation proceeds through an azaoxyallyl cation generated in situ from α-bromohydroxamate.

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Più fonti

Tesi sul tema "Isoquinoline"

1

Berg, Michael Arthur George. "Studies in the stereoselective synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines." Diss., This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-10032007-171522/.

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2

Jones, Michael William Chemistry Faculty of Science UNSW. "Enhancing the cooperative binding properties of 1,1'-bis(1,2,3,4-tetrahydroisoquinolines)." Awarded by:University of New South Wales. School of Chemistry, 2005. http://handle.unsw.edu.au/1959.4/27400.

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The design of partially reduced 1,1'-bisisoquinoline derivatives was investigated with the aim of controlling the conformation about the C1-C1' axis. This would produce ligands with unusual but predictable ligand binding properties, particularly cooperativity. The introduction of ??-aminoalkyl, ??-azidoalkyl, ??-alkynyl and ??-alkenyl groups onto the nitrogens of the reduced bisisoquinoline core was conducted with the intention of broadening the scope of the ligand. Subsequent epoxidation, hydroboration and Huisgen 1,3-dipolar cycloaddition of terminal unsaturated groups and nucleophilic displ

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3

Donaghy, Michael. "Studies in benzimidazo [2,1-a] isoquinoline chemistry." Thesis, Northumbria University, 2001. http://nrl.northumbria.ac.uk/1217/.

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Studies in Benzimidazo[2,1-a]isoquinoline Chemistry by Michael John Donaghy B. Sc. (Hons.) Ellipticine, a member of the pyrido[4,3-b]carbazole alkaloid family first isolated in 1959 from the leaves of the plant Ochrosia Elliptica has been shown to possess anti-cancer activity against various tumours. Ellipticine is thought to undergo biological oxidation to give the more active 9-hydroxyellipticine that is subsequently converted to a highly reactive quinone-imine intermediate. The quinone-imine is then thought to interact with bionucleophiles in the body promoting cell death. The aim of the pr

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4

Clifton, Mary Jennifer. "Studies in stereoselective synthesis via reissert compound chemistry." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-08222009-040256/.

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5

Guimond, Nicolas. "Part A: Rhodium-catalyzed Synthesis of Heterocycles / Part B: Mechanistic Studies on Tethering Organocatalysis Applied to Cope-type Alkene Hydroamination." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23222.

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The last decade has been marked by a large increase of demand for green chemistry processes. Consequently, chemists have focused their efforts on the development of more direct routes toward different classes of targets. In that regard catalysis has played a crucial role at enabling key bond formations that were otherwise inaccessible or very energy and resources consuming. The central theme of this body of work concerns the formation of C–N bonds, either through transition metal catalysis or organocatalysis. These structural units being highly recurrent in biologically active molecules, the e

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6

Ford, Alan John. "Synthesis of substituted isoquinoline ligands for homogeneous catalysis." Thesis, University of Hull, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361496.

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7

Muzanila, Charles Nobert. "Heterocyclic transformations involving #DELTA#'2-oxazolines and 1,2-benzisoxazoles." Thesis, University of Salford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327958.

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8

Hamilton, Lynne. "Synthesis, stereochemistry and reactions of quinoline, isoquinoline and acridine metabolites." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334710.

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9

Streetley, Guy Bradwell. "New approaches for the asymmetric synthesis of pyrroloisoquinoline and isoquinoline alkaloids." Thesis, Loughborough University, 2006. https://dspace.lboro.ac.uk/2134/34917.

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Abstract (sommario):

Pyrroloisoquinoline (n = 1) and the pyridoisoquinoline (n = 2) ring systems (2) are found to be the major structural motif of the Erythrina and the protoberberine group of alkaloids, respectively. We have recognised that suitable bicyclic lactams (1) could act as precursors, in an intramolecular N-acyliminium ion-mediated cyclisation, resulting in a stereoselective approach to the core of the Erythrina and protoberberine ring systems. [Illustration omitted.] Access to the tetracyclic core of the Erythrina alkaloids (3) through the application of N-acyliminium ion chemistry is well established

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10

Chow, Yit Lai. "Caenorhabditis elegans as a whole organism screening system for isoquinoline alkaloid bioactivities." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188834.

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Più fonti

Libri sul tema "Isoquinoline"

1

D, Phillipson J., Roberts M. F, Zenk M. H. 1933-, and Phytochemical Society of Europe, eds. The Chemistry and biology of isoquinoline alkaloids. Springer-Verlag, 1985.

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2

Bentley, K. W. The Isoquinoline alkaloids. Harwood Academic Pub., 1998.

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3

Phillipson, J. David, Margaret F. Roberts, and M. H. Zenk, eds. The Chemistry and Biology of Isoquinoline Alkaloids. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70128-3.

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4

1948-, Coppola Gary M., and Schuster Herbert F. 1949-, eds. Isoquinolines. Wiley, 1995.

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5

Antkiewicz-Michaluk, Lucyna, and Hans Rommelspacher, eds. Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants. Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-1542-8.

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6

The Chemistry of Heterocyclic Compounds, Isoquinolines (Chemistry of Heterocyclic Compounds: A Series Of Monographs). Wiley-Interscience, 1995.

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7

Rahman, A. U. Isoquinoline Alkaloids. Elsevier Science, 1994.

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8

Chemistry and Biology of Isoquinoline Alkaloids. Island Press, 1985.

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9

Schuster, Herbert F., and Gary M. Coppola. Isoquinolines, Part 3. Wiley & Sons, Incorporated, John, 2009.

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10

(Editor), F. G. Kathawala, Gary M. Coppola (Editor), and Herbert F. Schuster (Editor), eds. The Chemistry of Heterocyclic Compounds, Isoquinolines (Chemistry of Heterocyclic Compounds: A Series Of Monographs). 2nd ed. Wiley-Interscience, 1990.

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Capitoli di libri sul tema "Isoquinoline"

1

Lide, David R. "Isoquinoline." In Handbook of Organic Solvents. CRC Press, 2024. http://dx.doi.org/10.1201/9781003575191-295.

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2

Niwa, Toshimitsu, Mitsuharu Kajita, and Toshiharu Nagatsu. "Isoquinoline Derivatives." In Pharmacology of Endogenous Neurotoxins. Birkhäuser Boston, 1998. http://dx.doi.org/10.1007/978-1-4612-2000-8_1.

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3

Nagatsu, Toshiharu. "Isoquinoline Neurotoxins." In Neurotoxic Factors in Parkinson’s Disease and Related Disorders. Springer US, 2000. http://dx.doi.org/10.1007/978-1-4615-1269-1_7.

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4

Vogt, J. "715 C9H7N Isoquinoline." In Asymmetric Top Molecules. Part 3. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-14145-4_137.

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5

Wohlfarth, Ch. "Viscosity of isoquinoline." In Supplement to IV/18. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75486-2_313.

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6

Li, Jie Jack. "Pictet-Gams isoquinoline synthesis." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_233.

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7

dos Santos, Anderson R., and Nelissa P. Vaz. "Isoquinoline Alkaloids and Chemotaxonomy." In Sustainable Development and Biodiversity. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-30746-2_8.

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8

Wohlfarth, Ch. "Dielectric constant of isoquinoline." In Supplement to IV/6. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75506-7_278.

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9

Li, Jie Jack. "Pictet–Gams isoquinoline synthesis." In Name Reactions. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-03979-4_214.

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10

Seigler, David S. "Isoquinoline and Benzylisoquinoline Alkaloids." In Plant Secondary Metabolism. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4913-0_32.

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Atti di convegni sul tema "Isoquinoline"

1

Wang Guanghua, Yang Shuqin, Li Wenbing, et al. "Isolation and characterization of isoquinoline-degrading strain Y-4." In Environment (ICMREE). IEEE, 2011. http://dx.doi.org/10.1109/icmree.2011.5930957.

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2

O'Donnell, Ryan M., Autumn E. Moore, Jianmin Shi, et al. "Iridium complexes containing nitro-derivatized isoquinoline ligands for photonic applications." In Organic Photonic Materials and Devices XXI, edited by Christopher E. Tabor, François Kajzar, and Toshikuni Kaino. SPIE, 2019. http://dx.doi.org/10.1117/12.2508772.

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3

Gumus, Aysegul, Selcuk Gumus, and Duygu Yenidede. "Isoquinoline-substituted hybrid compounds: synthesis and computational studies." In The 20th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecsoc-20-a036.

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4

Silva, Wanderson Amaral da, Vinícius Rangel Campos, Angela Cristina P. B. dos Santos, et al. "The Ultrasound-accelerated Synthesis of New 7- Aminocarbohydrate-isoquinoline-5,8-quinone Derivatives." In 14th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0253-2.

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5

Penkevich, N. A., Yu P. Slapovskaya, A. A. Neveshkin, D. A. Zayarsky, and V. B. Bayburin. "Optical spectroscory of isoquinoline-1-carboxylate europium with sodium in various solvents." In 2014 International Conference on Actual Problems of Electron Devices Engineering (APEDE). IEEE, 2014. http://dx.doi.org/10.1109/apede.2014.6958228.

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6

Hung, J., J. Castillo, I. Laboren, M. Rodríguez, and M. Hassegawa. "Measurement of antiphotooxidative properties of isoquinoline alkaloids using transient thermal lens spectroscopy." In Optics East 2005, edited by Mostafa Analoui and David A. Dunn. SPIE, 2005. http://dx.doi.org/10.1117/12.630074.

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7

Couture, Axel, Pierre Grandclaudon, Eric Deniau, Stéphane Lebrun, and Mélanie Dubois. "Alternative synthetic approaches to biologically active indeno[1,2-c]isoquinoline-5,11-diones." In The 15th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2011. http://dx.doi.org/10.3390/ecsoc-15-00569.

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8

Cahlíková, L., A. Al Mamun, O. Janďourek, et al. "Short Lecture “Isoquinoline alkaloids and their derivatives as a new class of antimycobacterial drugs”." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758970.

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9

Vasilopoulos, S., I. Giannenas, K. Bitchava, et al. "Effect of isoquinoline alkaloids on trout performance antioxidant status and filet fatty acid profile." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759319.

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10

Wang, Lin, Lijuan Sun, and Yongmei Li. "Promotive Effect of Pyridine on the Biodegradation of Isoquinoline by Activated Sludge under Denitrifying Conditions." In 2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2009. http://dx.doi.org/10.1109/icbbe.2009.5163252.

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Rapporti di organizzazioni sul tema "Isoquinoline"

1

Blackwood, D. J., and S. Pons. An In Situ Surface Fourier Transform Infrared Study of the Adsorption of Isoquinoline at a Stationary Mercury Electrode. Defense Technical Information Center, 1988. http://dx.doi.org/10.21236/ada201685.

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2

Beasley, Jonathan. Synthesis of heterocycles: Indolo (2,1-a) isoquinolines, renewables, and aptamer ligands for cellular imaging. Office of Scientific and Technical Information (OSTI), 2013. http://dx.doi.org/10.2172/1082980.

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