Bibliografie tematiche / Lymphoid progenitors

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Letteratura scientifica selezionata sul tema "Lymphoid progenitors"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 7 febbraio 2022

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Articoli di riviste sul tema "Lymphoid progenitors"

Harly, Christelle, Maggie Cam, Jonathan Kaye, and Avinash Bhandoola. "Development and differentiation of early innate lymphoid progenitors." Journal of Experimental Medicine 215, no. 1 (2017): 249–62. http://dx.doi.org/10.1084/jem.20170832.

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Early innate lymphoid progenitors (EILPs) have recently been identified in mouse adult bone marrow as a multipotential progenitor population specified toward innate lymphoid cell (ILC) lineages, but their relationship with other described ILC progenitors is still unclear. In this study, we examine the progenitor–successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps). Functional, bioinformatic, phenotypical, and genetic approaches collectively establish EILPs as an intermediate progenitor between ALPs and ILCps. Our work additionally provides new cand

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Borikar, Sneha, Vivek Philip, Lauren Kuffler, and Jennifer J. Trowbridge. "Lysine Methyltransferase Kmt5a Restricts Myeloid-Biased Output of Lymphoid-Primed Multipotent Progenitors." Blood 128, no. 22 (2016): 1487. http://dx.doi.org/10.1182/blood.v128.22.1487.1487.

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Abstract Distinct, lineage-biased subsets of multipotent progenitor cells (MPP) dynamically respond to the demands of the hematopoietic system to replenish mature hematopoietic cells as needed. It currently remains unclear as to whether distinct epigenetic mechanisms regulate lineage-specific expansion and differentiation from MPPs. Focusing on lymphoid-primed multipotent progenitor cells (LMPP/MPP4), we performed a lentiviral shRNA screen of 15 epigenetic factors, selected based on differential expression between myeloid-restricted and lymphoid-restricted progenitors. Following a 48 hour infe

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Becker, Amy M., Drew G. Michael, Ansuman T. Satpathy, Roger Sciammas, Harinder Singh, and Deepta Bhattacharya. "IRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid mouse progenitors." Blood 119, no. 9 (2012): 2003–12. http://dx.doi.org/10.1182/blood-2011-06-364976.

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Abstract While most blood lineages are assumed to mature through a single cellular and developmental route downstream of HSCs, dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downstream lineages, we examined the transcriptional changes that accompany loss of in vivo myeloid potential as common myeloid progenitors differentiate into common DC progenitors (CDPs), and as lymphoid-primed multipotent progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs). Microarray studies revealed t

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Karsunky, Holger, Miriam Merad, Antonio Cozzio, Irving L. Weissman, and Markus G. Manz. "Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo." Journal of Experimental Medicine 198, no. 2 (2003): 305–13. http://dx.doi.org/10.1084/jem.20030323.

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Stimulation of Flt3 receptor tyrosine kinase through its cognate ligand expands early hematopoietic progenitor and dendritic cells (DCs) in humans and mice. The exact developmental stages at which hematopoietic progenitors express Flt3, are responsive to its ligand, and subsequently develop to DCs, are not known. Here we show that common lymphoid and common myeloid progenitors, as well as steady state DCs in thymus, spleen, and epidermis, express Flt3. The receptor is down-regulated once definitive B cell, T cell, and megakaryocyte/erythrocyte commitment occurs, and Flt3 is not detectable on o

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Buza-Vidas, Natalija, Petter Woll, Anne Hultquist, et al. "FLT3 expression initiates in fully multipotent mouse hematopoietic progenitor cells." Blood 118, no. 6 (2011): 1544–48. http://dx.doi.org/10.1182/blood-2010-10-316232.

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Abstract Lymphoid-primed multipotent progenitors with down-regulated megakaryocyte-erythroid (MkE) potential are restricted to cells with high levels of cell-surface FLT3 expression, whereas HSCs and MkE progenitors lack detectable cell-surface FLT3. These findings are compatible with FLT3 cell-surface expression not being detectable in the fully multipotent stem/progenitor cell compartment in mice. If so, this process could be distinct from human hematopoiesis, in which FLT3 already is expressed in multipotent stem/progenitor cells. The expression pattern of Flt3 (mRNA) and FLT3 (protein) in

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Sitnicka, Ewa, Natalija Buza-Vidas, Henrik Ahlenius, et al. "Critical role of FLT3 ligand in IL-7 receptor–independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors." Blood 110, no. 8 (2007): 2955–64. http://dx.doi.org/10.1182/blood-2006-10-054726.

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Abstract The molecular pathways regulating lymphoid priming, fate, and development of multipotent bone marrow (BM) stem/progenitor cells that continuously replace thymic progenitors remain largely unknown. Herein, we show that fms-like tyrosine kinase 3 (Flt3) ligand (Fl)–deficient mice have distinct reductions in the earliest thymic progenitors in fetal, postnatal, and adult thymus. A critical role of FL in thymopoiesis was particularly evident in the absence of interleukin-7 receptor α (IL-7Rα) signaling. Fl−/−Il-7r−/− mice have extensive reductions in fetal and postnatal thymic progenitors

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Ryan, Daniel H., Bonnie L. Nuccie, Ion Ritterman, Jane L. Liesveld, Camille N. Abboud, and Richard A. Insel. "Expression of Interleukin-7 Receptor by Lineage-Negative Human Bone Marrow Progenitors With Enhanced Lymphoid Proliferative Potential and B-Lineage Differentiation Capacity." Blood 89, no. 3 (1997): 929–40. http://dx.doi.org/10.1182/blood.v89.3.929.

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Abstract Relatively little is known about the relationship of lymphoid-associated gene expression to the proliferation and differentiation potential of early human bone marrow lymphoid progenitors. Surface expression of interleukin-7 (IL-7) receptor-α (IL-7Rα), a component of the high-affinity receptor for the lymphoid precursor growth factor IL-7, defined a CD34+ progenitor subset lacking the CD19+ pro-B phenotype but demonstrating markedly enhanced lymphoid clonogenic capacity and the ability to differentiate into pro-B cells in short-term culture. These progenitors expressed mRNA for the ly

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Arinobu, Yojiro, Shin-ichi Mizuno, Hirokazu Shigematsu, et al. "Delineation of the Common Developmental Pathway for Granulocyte/Monocyte and Lymphoid Lineages by Using an Expression Reporter for PU.1." Blood 108, no. 11 (2006): 1656. http://dx.doi.org/10.1182/blood.v108.11.1656.1656.

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Abstract Understanding how multipotent cells commit to each of their terminal fate potentials is an important aspect of stem cell biology. Hematopoietic stem cells (HSCs) of Lin −Sca-1+c-Kit+ (LSK) phenotype have been purified, which were further divided into CD34-long-term and CD34+ short-term (ST)-HSCs. The existence of phenotypically isolatable common lymphoid progenitors (CLPs) and common myeloid progenitors (CMPs) downstream of ST-HSCs suggests that the first commitment step after the HSC stage is the bifurcation of lymphoid vs. myeloid pathway. Recent studies, however, suggest that the l

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Katsura, Yoshimoto. "Redefinition of lymphoid progenitors." Nature Reviews Immunology 2, no. 2 (2002): 127–32. http://dx.doi.org/10.1038/nri721.

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Loughran, Stephen J., Federico Comoglio, Fiona K. Hamey, et al. "Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program." Journal of Experimental Medicine 214, no. 10 (2017): 3085–104. http://dx.doi.org/10.1084/jem.20161827.

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Differentiation of lineage-committed cells from multipotent progenitors requires the establishment of accessible chromatin at lineage-specific transcriptional enhancers and promoters, which is mediated by pioneer transcription factors that recruit activating chromatin remodeling complexes. Here we show that the Mbd3/nucleosome remodeling and deacetylation (NuRD) chromatin remodeling complex opposes this transcriptional pioneering during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibility at B cell enhancers and promoters. Mbd3/NuRD-deficient lymphoid p

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Più fonti

Tesi sul tema "Lymphoid progenitors"

Zandi, Sasan. "What’s in a name? : Sub-fractionation of common lymphoid progenitors." Doctoral thesis, Linköpings universitet, Experimentell hematologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-61590.

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The hematopoietic system is a highly dynamic organ developed in many multi-cellular organisms to provide oxygen, prevent bleeding and to protect against microorganisms. The blood consist of many different specialized cells that all derive from rare hematopoietic stem cells (HSCs) located in the bone marrow in mice and humans. Blood cell production from HSCs occurs in a stepwise manner through development of intermediate progenitors that gradually loose lineage potentials. This is a tightly regulated process with complex regulatory mechanisms and many checkpoints that ensure a high and balanced

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Lemoine, François Michel. "Studies of the interactions between stromal cells and B lymphoid progenitors." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28856.

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The overall goal of the work, described in this thesis was to investigate the molecular mechanisms that regulate normal pre-B cell proliferation and how these may be altered in transformed pre-B cells. Monoclonal antibodies and molecular biological techniques have allowed a number of stages of pre-B cell differentiation to be defined but little is known about mechanisms controlling their proliferation. Studies of pre-B cell production in animal models and in long-term cultures that support pre-B cell proliferation have suggested that stromal cells play a key role in this regard. As a first st

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Rondeau, Vincent. "Rôle de la désensibilisation de CXCR4 dans la spécification lympho-myéloïde des progéniteurs hématopoïétiques multipotents. Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization New method to obtain lymphoid progenitors CXCR4-driven mitochondrial metabolic pathways shape the lympho-myeloid fate of hematopoietic multipotent progenitors." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ022.

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Les cellules souches et progéniteurs hématopoïétiques (CSPHs), incluant les progéniteurs multipotents (MPPs), sont responsables de la production des cellules immunes circulantes. Ils résident dans la moelle osseuse (MO) au sein de structures spécialisées, les niches endostéale et (péri)-vasculaire, qui régulent la spécification et l'engagement lymphoïde versus myéloïde des CSPHs. Dans la MO, le couple formé par la chimiokine CXCL12 et l’un de ses récepteurs, CXCR4, exerce un rôle clé dans la régulation de la rétention et la quiescence des CSPHs. Ces processus sont dérégulés dans le Syndrome WH

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Reimann, Christian. "In-vitro Generation of potent T-lymphoid Progenitors in a feeder-cell-free DL-4 system." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00771452.

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Human leukocyte antigen (HLA)-mismatched haematopoietic stem cell transplantation (HSCT) represents an important therapeutic option for patients lacking suitable donors. Delayed posttransplant immune recovery constitutes one of its major complications and is most pronounced in the T cellular compartment. A novel strategy to promote de novo thymopoiesis from donor derived HSCs and to accelerate T cellular reconstitution in patients after HSCT consists in the adoptive transfer of in vitro generated T cell progenitor cells. Identification of Notch1 as the key regulator of early T-lineage developm

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Moreira, Pedro Miguel Lopes. "Role of Notch signaling on the differentiation of early lymphoid progenitors cells: a view throughout the development of the embryonic chicken thymus and spleen." Master's thesis, Faculdade de Ciências e Tecnologia, 2014. http://hdl.handle.net/10362/13012.

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Dissertação para a obtenção do grau de Mestre em Genética Molecular e Biomedicina<br>The lymphoid organs, thymus and spleen, are essential for the differentiation of T and B cells, respectively. One of the signaling pathways involved in processes of cell differentiation is the Notch signaling pathway. Work conducted by our group demonstrated that Notch ligands, receptors and target genes are expressed in the thymic epithelium. In this work, we aimed: 1) to study the organogenesis of the thymus and spleen in chicken embryos; 2) phenotypically characterize the cells present in both organs; 3) t

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Michaels, Lopez Victoria. "Étude de la migration thymique : vers une reconstitution optimale du compartiment T." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB097/document.

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Notre équipe s’intéresse à la différenciation des cellules souches hématopoïétiques (CSH) vers la lignée des lymphocytes T. Contrairement aux autres lignées sanguines, qui se développent dans la MO, les progéniteurs des lymphocytes T doivent terminer leur différenciation dans le thymus. Ma thèse a un double objectif: 1) caractériser les progéniteurs candidats à la reconstitution T pour établir leur contribution à celle-ci et 2) identifier les stades initiaux de la reconstitution T. Nous avons mis en évidence que seul le progéniteur multipotent au stade 3 (MPP3 : Lin- Sca1+ c-Kit+ VCAM1- Flt3+)

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Chabaane, Amna. "Étapes précoces de la lymphopoïèse humaine." Thesis, Université Paris sciences et lettres, 2020. http://www.theses.fr/2020UPSLP027.

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La lymphopoïèse humaine reste mal caractérisée comparativement à son homologue murin. Ceci est dû à l’absence de modèles expérimentaux adéquats et aux difficultés d’accès aux prélèvements primaires de moelle osseuse humaine. Grâce à la caractérisation fine des populations de progéniteurs et précurseurs lymphoïdes présentes dans la moelle osseuse d’animaux greffés, nous avons récemment démontré que la lymphopoïèse humaine suit des voies CD127- ou CD127+ indépendantes qui génèrent une descendance lymphoïde commune et spécifique. Dans cette étude, nous avons mis au point un nouveau test de divers

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Larbi, Aniya. "Les cellules souches embryonnaires humaines, un modèle d’étude des étapes précoces de la lymphopoïèse." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA114808.

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Les cellules souches embryonnaires humaines (CSEh) sont des outils puissants pour explorer la genèse des différents tissus de l’organisme, notamment le tissu hématopoïétique. Dans le but d’obtenir des types cellulaires cliniquement utiles, la majorité des travaux se sont concentrés sur l’obtention des cellules hématopoïétiques terminales, notamment des cellules lymphoïdes (lymphocytes B, lymphocyte T et cellules NK), à partir des cellules souches pluripotentes humaines. En revanche, le rendement des cellules hématopoïétiques obtenues dans ce modèle reste faible. D’autre part, les étapes précoc

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Ghaedi, Maryam. "Common lymphoid progenitor-independent pathways of innate and T lymphocyte development." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52878.

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All lymphocytes are thought to develop from a single population of committed lymphoid progenitors termed common lymphoid progenitors (CLPs). However, upstream progenitors termed lymphoid-primed multi-potent progenitors (LMPPs) are known to be more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s), suggesting alternative pathways of their development. Here, we have divided LMPPs into CD127- (LMPP-s) and CD127+ (LMPP+s) subsets and compared them with CLPs. Adult LMPP+s are the most efficient progenitors for T cells and ILCs in transplantation assays, a

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Leyland, R. J. "Lineage relationship analysis of lymphoid progenitor subsets in the bone marrow of naïve mice and during inflammation." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1322960/.

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During haematopoiesis multipotent stem cells generate all cellular components of the blood including lymphocytes. Despite great progress in the isolation of lineage restricted progenitors, the exact precursor-product relationship of these subsets remains poorly understood. In particular the exact branch point of T- and B-cell development in the bone marrow has not been unequivocally mapped. The aim of my project was to investigate the developmental relationship of various progenitor subsets in normal mice and during an acute inflammation. In order to permanently identify all cells which emanat

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Più fonti

Capitoli di libri sul tema "Lymphoid progenitors"

Ezine, Sophie, Laetitia Gautreau, Aude Parcelier, and Bruno Canque. "Developmental Biology of Mammalian T-Cell Progenitors: From Early Lymphoid Progenitors to Thymus-Colonizing Cells." In Hematopoietic Stem Cell Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60327-347-3_4.

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Scott, Edward W. "The Role of PU.1 in the Regulation of Lymphoid and Myeloid Hematopoietic Progenitors." In Molecular Biology of B-Cell and T-Cell Development. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4757-2778-4_7.

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Scherle, P. A., and O. N. Witte. "Functionality of Clonal Lymphoid Progenitor Cells Expressing the P210 BCR/ABL Oncogene." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75889-8_24.

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Haas, R., H. Goldschmidt, R. Möhle, et al. "High-dose Therapy and Autografting with Mobilized Peripheral Blood Progenitor Cells in Patients with Malignant Lymphoma." In Acute Leukemias V. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-78907-6_67.

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Lemoli, Roberto M., Alessandra Fortuna, Miriam Fogli, et al. "Combined Use of Growth Factors to Stimulate the Proliferation of Hematopoietic Progenitor Cells after Autologous Bone Marrow Transplantation (ABMT) for Lymphoma Patients." In Molecular Biology of Hematopoiesis 5. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-0391-6_2.

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Hardy, R. R., J. D. Kemp, and K. Hayakawa. "Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74974-2_3.

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Crooks, Gay M. "Common Lymphoid Progenitors." In Handbook of Stem Cells. Elsevier, 2004. http://dx.doi.org/10.1016/b978-012436643-5/50123-1.

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Bendari, Mounia, Sofia Sraidi, and Nisrine Khoubila. "Genetic Abnormalities in ALL." In Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97429.

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Abstract (sommario):

Acute lymphoblastic leukemia (ALL), can be defined by a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL constitutes the most common childhood cancer, due to an overproduction of immature lymphoid hematopoietic cells. Genetic analyzes currently provides important information for classifying patients into prognostic groups, genetic analysis also helps to understand the mechanisms of relapse, pharmacogenetics and the development of new potential therapeutic targets, which should help to further improve the results of leukemia. In fact, the new techniques in molecular cytogenetic permits to identify new cryptic abnormalities, these discoveries have led to the development of new therapeutic protocols. The role of cytogenetic analysis is crucial on ALL patient’s management. Karyotyping coupled with FISH analysis identifies recurrent chromosomal abnormalities in ALL, many of these abnormalities have prognostic and treatment impact. This chapter summarizes chromosomal abnormalities that are common and classify ALL according to the World Health Organization (WHO) classifications (2016 revision). We will present the main genetic modifications recently identified as well as the sequence mutations which have helped in the elucidation of the pathogenesis of ALL.

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Paige, Christopher J., and Roland H. Gisler. "Adherent layer-dependent development of B cell progenitors in semisolid agar." In Immunochemical Techniques Part K: In Vitro Models of B and T Cell Functions and Lymphoid Cell Receptors. Elsevier, 1987. http://dx.doi.org/10.1016/0076-6879(87)50082-9.

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Becerra Becerra, Edgardo, and Guadalupe García-Alcocer. "MicroRNAs and Their Role in Acute Lymphoblastic Leukemia." In Acute Leukemias [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94960.

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Acute lymphoblastic leukemia (ALL) has been established as the most common acute leukemia in children, accounting for 80–85% of cases. ALL occurs mostly in children and it is considered as a high-risk disease in the elderlies. ALL is characterized by a clonal disorder where the normal hematopoiesis is replaced by a malignant clonal expansion of lymphoid progenitors. Although many therapeutic strategies have been established to treat ALL leading to improved survival rates, the short-term and long-term complications derived from treatment toxicity represent a critical risk for patients. The treatment-related toxicity suggests a need for the development of new therapy strategies to effectively treat high-risk and low-risk disease. Nowadays, an important approach is focused on the identification of molecules involved in the mechanisms that lead to leukemia generation and progression to determine potential targets at the transcriptional level. MicroRNAs (miRNAs) are a group of key molecules that regulate signaling pathways related to lymphopoiesis. miRNAs participate in the regulation of hematopoietic differentiation and proliferation, as well as their activity. The present review details the recompilation of evidences about the relation between miRNAs and lymphopoiesis, ALL development and progression in order to propose and explore novel strategies to modulate ALL-related miRNA levels as a therapeutic approach.

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Atti di convegni sul tema "Lymphoid progenitors"

Woodcroft, Mark W., Takyuki Murase, and David P. LeBrun. "Abstract 3097: The leukemogenic protein E2A-PBX1 blocks B-lymphoid commitment in early hematopoietic progenitors." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-3097.

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Lechman, Eric R., Karin G. Hermans, Stephanie Dobson, Kolja Eppert, Mark Minden, and John E. Dick. "Abstract 2292: Enforced expression of miR-125b promotes the in vivo expansion of human Lin- CB multi-lymphoid progenitors (MLP) and AML leukemia stem cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2292.

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Ito, Daisuke, Anne C. Avery, Nicola J. Mason, Tim D. O'Brien, and Jaime F. Modiano. "Abstract 4307: Characterization of a novel lymphoid progenitor population with predictive value in canine non-Hodgkin lymphoma." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4307.

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Rapporti di organizzazioni sul tema "Lymphoid progenitors"

Cooper, Laurence, and Rita Young. Development of Augmented Leukemia/Lymphoma-Specific T-Cell Immunotherapy for Deployment with Haploidentical, Hematompoietic Progenitor-Cell Transplant. Defense Technical Information Center, 2008. http://dx.doi.org/10.21236/ada487262.

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Cooper, Laurence. Development of Augmented Leukemia/Lymphoma-Specific T-Cell Immunotherapy for Deployment with Haploidentical, Hematompoietic Progenitor-Cell Transplant. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada560655.

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