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Letteratura scientifica selezionata sul tema "Macrocycles"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 9 giugno 2025

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Articoli di riviste sul tema "Macrocycles"

Abdelraheem, Eman, Shabnam Shaabani, and Alexander Dömling. "Artificial Macrocycles." Synlett 29, no. 09 (May 7, 2018): 1136–51. http://dx.doi.org/10.1055/s-0036-1591975.

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Artificial macrocycles recently became popular as a novel research field in drug discovery. As opposed to their natural twins, artificial macrocycles promise to have better control on synthesizability and control over their physicochemical properties resulting in druglike properties. Very few synthetic methods allow for the convergent, fast but diverse access to large macrocycles chemical space. One synthetic technology to access artificial macrocycles with potential biological activity, multicomponent reactions, is reviewed here, with a focus on our own work. We believe that synthetic chemists have to acquaint themselves more with structure and activity to leverage the design aspect of their daily work.1 Introduction2 Macrocycle Properties and Receptor Binding3 Synthetic Approaches towards Artificial Macrocycles Using MCR4 Design Rules for Membrane Crossing Macrocycles5 Design Rules for Libraries of Macrocycles6 Computational Macrocyclic Methods7 Future View

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Singh, Kartikey, and Rama Pati Tripathi. "An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry." Current Medicinal Chemistry 27, no. 20 (June 7, 2020): 3386–410. http://dx.doi.org/10.2174/0929867326666190227232721.

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Macrocycles cover a small segment of molecules with a vast range of biological activity in the chemotherapeutic world. Primarily, the natural sources derived from macrocyclic drug candidates with a wide range of biological activities are known. Further evolutions of the medicinal chemistry towards macrocycle-based chemotherapeutics involve the functionalization of the natural product by hemisynthesis. More recently, macrocycles based on carbohydrates have evolved a considerable interest among the medicinal chemists worldwide. Carbohydrates provide an ideal scaffold to generate chiral macrocycles with well-defined pharmacophores in a decorated fashion to achieve the desired biological activity. We have given an overview on carbohydrate-derived macrocycle involving their synthesis in drug design and discovery and potential role in medicinal chemistry.

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Zhong, Chunxiao, Yong Yan, Qian Peng, Zheng Zhang, Tao Wang, Xin Chen, Jiacheng Wang, Ying Wei, Tonglin Yang, and Linghai Xie. "Structure–Property Relationship of Macrocycles in Organic Photoelectric Devices: A Comprehensive Review." Nanomaterials 13, no. 11 (May 27, 2023): 1750. http://dx.doi.org/10.3390/nano13111750.

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Macrocycles have attracted significant attention from academia due to their various applications in organic field-effect transistors, organic light-emitting diodes, organic photovoltaics, and dye-sensitized solar cells. Despite the existence of reports on the application of macrocycles in organic optoelectronic devices, these reports are mainly limited to analyzing the structure–property relationship of a particular type of macrocyclic structure, and a systematic discussion on the structure–property is still lacking. Herein, we conducted a comprehensive analysis of a series of macrocycle structures to identify the key factors that affect the structure–property relationship between macrocycles and their optoelectronic device properties, including energy level structure, structural stability, film-forming property, skeleton rigidity, inherent pore structure, spatial hindrance, exclusion of perturbing end-effects, macrocycle size-dependent effects, and fullerene-like charge transport characteristics. These macrocycles exhibit thin-film and single-crystal hole mobility up to 10 and 26.8 cm2 V−1 s−1, respectively, as well as a unique macrocyclization-induced emission enhancement property. A clear understanding of the structure–property relationship between macrocycles and optoelectronic device performance, as well as the creation of novel macrocycle structures such as organic nanogridarenes, may pave the way for high-performance organic optoelectronic devices.

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Fan, Linmeng, Min Du, Lichun Kong, Yan Cai, and Xiaobo Hu. "Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection." Molecules 28, no. 3 (January 31, 2023): 1338. http://dx.doi.org/10.3390/molecules28031338.

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Traditional macrocyclic molecules encode recognition sites in their structural backbones, which limits the variation of the recognition sites and thus, would restrict the adjustment of recognition properties. Here, we report a new oligoamide-based macrocycle capable of varying the recognition functional groups by post-synthesis modification on its structural backbone. Through six steps of common reactions, the parent macrocycle (9) can be produced in gram scale with an overall yield of 31%. The post-synthesis modification of 9 to vary the recognition sites are demonstrated by producing four different macrocycles (10–13) with distinct functional groups, 2-methoxyethoxyl (10), hydroxyl (11), carboxyl (12) and amide (13), respectively. The 1H NMR study suggests that the structure of these macrocycles is consistent with our design, i.e., forming hydrogen bonding network at both rims of the macrocyclic backbone. The 1H-1H NOESY NMR study indicates the recognition functional groups are located inside the cavity of macrocycles. At last, a preliminary molecular recognition study shows 10 can recognize n-octyl-β-D-glucopyranoside (14) in chloroform.

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Guo, Hao, Yu-Fei Ao, De-Xian Wang, and Qi-Qiang Wang. "Bioinspired tetraamino-bisthiourea chiral macrocycles in catalyzing decarboxylative Mannich reactions." Beilstein Journal of Organic Chemistry 18 (May 2, 2022): 486–96. http://dx.doi.org/10.3762/bjoc.18.51.

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A series of tetraamino-bisthiourea chiral macrocycles containing two diarylthiourea and two chiral diamine units were synthesized by a fragment-coupling approach in high yields. Different chiral diamine units, including cyclohexanediamines and diphenylethanediamines were readily incorporated by both homo and hetero [1 + 1] macrocyclic condensation of bisamine and bisisothiocyanate fragments. With the easy synthesis, gram-scale of macrocycle products can be readily obtained. These chiral macrocycles were applied in catalyzing bioinspired decarboxylative Mannich reactions. Only 5 mol % of the optimal macrocycle catalyst efficiently catalyzed the decarboxylative addition of a broad scope of malonic acid half thioesters to isatin-derived ketimines with excellent yields and good enantioselectivity. The rigid macrocyclic framework and the cooperation between the thiourea and tertiary amine sites were found to be crucial for achieving efficient activation and stereocontrol. As shown in control experiments, catalysis with the acyclic analogues having the same structural motifs were non-selective.

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Sun, Dianqing. "Recent Advances in Macrocyclic Drugs and Microwave-Assisted and/or Solid-Supported Synthesis of Macrocycles." Molecules 27, no. 3 (February 2, 2022): 1012. http://dx.doi.org/10.3390/molecules27031012.

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Macrocycles represent attractive candidates in organic synthesis and drug discovery. Since 2014, nineteen macrocyclic drugs, including three radiopharmaceuticals, have been approved by FDA for the treatment of bacterial and viral infections, cancer, obesity, immunosuppression, etc. As such, new synthetic methodologies and high throughput chemistry (e.g., microwave-assisted and/or solid-phase synthesis) to access various macrocycle entities have attracted great interest in this chemical space. This article serves as an update on our previous review related to macrocyclic drugs and new synthetic strategies toward macrocycles (Molecules, 2013, 18, 6230). In this work, I first reviewed recent FDA-approved macrocyclic drugs since 2014, followed by new advances in macrocycle synthesis using high throughput chemistry, including microwave-assisted and/or solid-supported macrocyclization strategies. Examples and highlights of macrocyclization include macrolactonization and macrolactamization, transition-metal catalyzed olefin ring-closure metathesis, intramolecular C–C and C–heteroatom cross-coupling, copper- or ruthenium-catalyzed azide–alkyne cycloaddition, intramolecular SNAr or SN2 nucleophilic substitution, condensation reaction, and multi-component reaction-mediated macrocyclization, and covering the literature since 2010.

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Kim, Taegwan, Eunbee Baek, and Jonghoon Kim. "Exploring Macrocyclic Chemical Space: Strategies and Technologies for Drug Discovery." Pharmaceuticals 18, no. 5 (April 24, 2025): 617. https://doi.org/10.3390/ph18050617.

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Macrocycles have emerged as significant therapeutic candidates in drug discovery due to their unique capacity to target complex and traditionally inaccessible biological interfaces. Their structurally constrained three-dimensional configurations facilitate high-affinity interactions with challenging targets, notably protein–protein interfaces. However, despite their potential, the synthesis and optimization of macrocyclic compounds present considerable challenges related to structural complexity, synthetic accessibility, and the attainment of favorable drug-like properties, particularly cell permeability and oral bioavailability. Recent advancements in synthetic methodologies have expanded the chemical space accessible to macrocycles, enabling the creation of structurally diverse and pharmacologically active compounds. Concurrent developments in computational strategies have further enhanced macrocycle design, providing valuable insights into structural optimization and predicting molecular properties essential for therapeutic efficacy. Additionally, a deeper understanding of macrocycles’ conformational adaptability, especially their ability to internally shield polar functionalities to improve membrane permeability, has significantly informed their rational design. This review discusses recent innovations in synthetic and computational methodologies that have advanced macrocycle drug discovery over the past five years. It emphasizes the importance of integrating these strategies to overcome existing challenges, illustrating how their synergy expands the therapeutic potential and chemical diversity of macrocycles. Selected case studies underscore the practical impact of these integrated approaches, highlighting promising therapeutic applications across diverse biomedical targets.

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Li, Yu, Wei Zhao, and Biao Wu. "Tetraurea Macrocycles: Template-Directed One-Pot Synthesis and Anion Binding Properties." Advances in Engineering Technology Research 6, no. 1 (June 19, 2023): 228. http://dx.doi.org/10.56028/aetr.6.1.228.2023.

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Given the significance of anion in life, study of anion recognition attracted great attentions in the past decades. Macrocyclic receptors display intriguing anion binding properties; however, the synthesis of macrocycles is challenging. Here, we reported a new strategy of making tetraurea in one-step. By using 1-butyl-3-methylimidazolium ([hmim][X], X = anion) as the solvent and template reagent, tetraurea macrocycle comprised of bis(urea) binding moiety and hexyl chain spacers is selectively formed with high yield. The obtained macrocycles displayed interesting anion binding properties as indicated by single crystal X-ray diffraction structures and computational modelling.

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Chia, PSK, A. Ekstrom, I. Liepa, LF Lindoy, M. Mcpartlin, SV Smith, and PA Tasker. "New Macrocyclic Ligands. II. Pendant Hydroxyethyl, Cyanoethyl and Carbamoylethyl Arm Systems Derived From O2N2-Donor Rings: the X-Ray Structure of a Pendant Hydroxyethyl Derivative." Australian Journal of Chemistry 44, no. 5 (1991): 737. http://dx.doi.org/10.1071/ch9910737.

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The syntheses and characterization of 12 new 14- to 17-membered macrocycles incorporating pendant hydroxyethyl cyanoethyl or carbamoylethyl groups are reported. The macrocyclic ring in each of these new ligands contains an O2N2-donor set. The X-ray structure of the di(hydroxyethyl) derivative of the 14-membered macrocycle is described.

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Mohammed, Shaymaa Adil. "Synthesis and Characterization of Some New Polymeric Macrocycle (Thia-Crown Ether) and Study Biological Activity." International Journal of Medical and All Body Health Research 6, no. 2 (2025): 87–98. https://doi.org/10.54660/ijmbhr.2025.6.2.87-98.

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This study investigates the synthesis, characterization, and biological activity of novel polymeric thia-crown ethers. On of the best solutions to save time and costs by mobilizing the chiral macrocycles on polymers which allows the recyclability and green conditions, The selecting of glucose as a model for the synthesis of macrocyclic thia crown ether The synthesis of thia-crown ether is started with protection of 4,6-positions on methyl D-glucopyranoside 1 by benzylidene protecting group, the reaction of compound 2 with bis(2-chloroethyl)ether under basic conditions to get compound 3 to obtain the structure which is ready to build up the macrocycle, the chloride can be enhanced by replacing it by iodide applying Flenksteien reaction to get compound 4. The macrocycle5 was treated in different reagent to get two derivatives in which 6 has only one free hydroxyl group, and 7 with two functional groups The compound 6 was crafted the PVC in order to obtain the target linear polymer 8. In the same context, the cross-linked polymer 9. All the compounds and polymers have been characterized by the instrumental techniques, include FT-IR, 1HNMR, 13CNMR and FESEM. The macrocycles 6, 7 and its polymeric materials was examined against two strains of bacteria, Gram + and Gram.

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Tesi sul tema "Macrocycles"

Azarias, Cloé. "Modeling azacalixphyrin macrocycles." Thesis, Nantes, 2018. http://www.theses.fr/2018NANT4021/document.

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Cette thèse porte sur la modélisation des propriétés structurales, aromatiques et spectroscopiques d'une nouvelle classe de macrocycles alternatifs aux porphyrines, les azacalixphyrines (ACPs). Ces macrocycles conjugués, synthétisés et caractérisés pour la première fois en 2010 par le groupe d’Olivier Siri à Marseille, ont montré des propriétés exceptionnelles (structure, absorption, tautomérie, et complexation). Cette thèse vise à proposer de nouveaux dérivés aux propriétés améliorées, notamment en ce qui concerne leur absorption, en utilisant les outils offerts par la chimie théorique. Parmi toutes les approches ab initio permettant de modéliser les ACPs, la théorie fonctionnelle de la densité (DFT) et sa forme dépendante du temps (TDDFT) ont été principalement appliquées, bien que des calculs utilisant des méthodes alternatives aient également été effectués, notamment à l'aide du formalisme Bethe-Salpeter (BSE/evGW) dans le cadre d'une collaboration avec l'équipe du Dr. Xavier Blase à Grenoble. Trois stratégies chimiques ont été évaluées: (i) l’extension de la délocalisation des électrons  en fusionnant plusieurs unités ACP; (ii) la substitution de l’ACP via l'addition de groupes électroactifs; et (iii) le couplage du macrocycle avec un fluorophore présentant une absorption complémentaire afin d'absorber la lumière sur une plus grande gamme du spectre et déclencher des processus de transfert d'énergie entre les sous-unités. Les deux premiers axes ont été réalisés en collaboration avec l'équipe d’Olivier Siri alors que le dernier est le fruit d'une collaboration avec le groupe de Benedetta Mennucci à Pise<br>This thesis focuses on the modeling of the structural, aromatic, and spectroscopic properties of a new class of macrocycles alternative to porphyrins, i.e., azacalixphyrins (ACPs). These conjugated macrocycles have first been synthesized and characterized in 2010 by Siri’s group in Marseille and revealed exceptional features (structure, NIR absorption, tautomerism, and complexation). This thesis aimed at using ab initio methods to propose new ACP derivatives with improved properties with a focus on their absorption. The Density Functional Theory (DFT) and Time- Dependent DFT (TD-DFT) methods have been predominantly applied, although alternative wavefunction-based theories [the second-order Coupled-Cluster, CC2, and the Algebraic Diagrammatic Construction, ADC(2)] as well as the Bethe-Salpeter formalism, BSE/evGW, have also been used. Three major directions to develop new ACP derivatives have been investigated: (i) the extension of the ACP -conjugation path by fusing several ACP moieties leading to multimers; (ii) chemical modifications of the ACP unit by addition of electroactive groups; and (iii) coupling of the ACP moiety with a fluorophore presenting a complementary absorption spectrum in order to improve the light harvesting and to trigger excitation energy transfer processes. The two former axes have been investigated in collaboration with Siri’s team whereas the latter has arisen from a collaboration with the Mennucci’s group

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Danso-Danquah, Richmond Edward. "Syntheses of polypyrrolic macrocycles." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26240.

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Pentaphyrins are pentapyrrolic macrocycles containing five bridging methine groups between the five pyrrolic subunits. The syntheses of decamethylpentaphyrin 71, 2-ethoxycarbonyl-3,7,8,12,13,17,18,22,23-nonamethylpentaphyrin 74, 2-ethoxycarbonyl-3,7,8,22,23-pentamethyl-12,13,17,18-tetraethylpentaphyrin 75, 3,12-dimethoxycarbonylethyl-2,7,8,-13,17,18,22,23-octamethylpentaphyrins 29 and the zinc complexes of 71 and 74 are described. The physical properties of the pentaphyrins show them to be aromatic like sapphyrins, porphyrins and corroles. This aromaticity is reflected in the large shielding of the NH protons and the deshielding of the methine protons in the nmr spectra and by their optical spectra, which exhibit Soret and visible bands similar to sapphyrins and porphyrins.<br>Science, Faculty of<br>Chemistry, Department of<br>Graduate

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Norman, Timothy John. "Radioimmunotherapy with yttrium macrocycles." Thesis, Durham University, 1994. http://etheses.dur.ac.uk/5529/.

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Monoclonal antibody fragments (Fab') which recognise tumour-associated antigens provide an ingenious means of selectively targeting a therapeutic radionuclide to a tumour for radioimmunotherapy. The radionuclide yttrium-90, a long range β(^-) emitter, was chosen to deliver a sterilising dose of radiation to the tumour. A selection of novel functionalised macrocyclic ligands based on a 1,4,7,10-tetraazacyclododecane skeleton have been synthesised, and the stabilities of their yttrium (III) and gadolinium (III) complexes studied in vitro through association and dissociation measurements, and in vivo through animal biodistribution studies. The radiolabelled complexes do not dissociate in vivo. Maleimides are compounds which are capable of selectively reacting with a thiol of an antibody fragment. Selective functionalisation of one of the yttrium binding macrocyclic ligands with either one or three maleimides has been carried out, and the resulting compounds conjugated to tumour seeking humanised antibody fragments. Subsequent radiolabelling with (^90)Y, gave the desired tumour targeting drug for use in radioimmunotherapy. Acridines are a class of intercalating agents which are capable of reversibly binding to DNA. A maleimide functionalised ligand derivatised with acridine was formed. Conjugation of this compound to antibody fragments capable of entering a tumour cell, may permit drug binding to tumour cell DNA, and thus enhance the targeting efficacy of the radiolabelled conjugate.

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Matthes, Karen Elizabeth. "Chemistry of functionalised macrocycles." Thesis, Durham University, 1987. http://etheses.dur.ac.uk/6704/.

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The work reported in this thesis is divided into two distinct areas. The first involves the synthesis of monoaza- and diaza-[12]-ring macrocycles, with differing side-arm N-substituents. The twelve-membered macrocycles possess a convenient ring-size for exploring the stability and selectivity of complexation of small cations, in particular those from groups IA and IIA. Amide substituents on nitrogen were expected to function as effective σ-donors to cations with high charge density (e.g. Li (^+), Ca (^2)(^+)), because of their high ground state dipole moments. The effect of the length of the side-arms attached to nitrogen on the complexation has also been studied. Complexation behaviour has been probed using (^13)C NMR spectroscopy, titration calorimetry, and fast-atom bombardment mass spectroscopy. Copper (II) complexes of three of the [12]-ring cycles have also been characterised by X-ray crystallographic analysis. The second area involves the study of a series of macrocyclic ligands capable of forming homo- and hetero-dinuclear complexes. In particular, ligands containing the pyridyl-dithio (PyS(_2)) binding unit and a polyether chain linking the two sulphur atoms have been examined. The three binding atoms of each PyS (_2) group define three corners of a fairly rigid square planar environment which favours the formation of square planar d(^8) complexes. Accordingly, complexation with rhodium (I) [and (III)], palladium (II), and platinum (II) has been investigated: the structural properties of these complexes have been determined by the use of FT NMR and X-ray crystallography.

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Sloman, Zachary Scott. "Novel thiophene based macrocycles." Thesis, Nottingham Trent University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297724.

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Marrs, Deborah Jane. "Macrocycles, macrobicycles : a study." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.257447.

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Colombo-Khater, Dominique. "Macrocycles polyhétéroatomiques : synthèse, complexation." Toulouse 3, 1993. http://www.theses.fr/1993TOU30001.

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Depuis quelques annees, de nombreux macrocycles phosphores contenant des heteroatomes ont ete prepares dans le but d'obtenir des especes capables de complexer selectivement des cations voire meme des especes neutres. La methode de synthese mise au point au laboratoire en 1988 consiste a faire reagir un dialdehyde sur un phosphodihydrazide. Il s'agit d'une methode simple et generale de synthese de macrocycles polyphosphores. La reaction mise en jeu est une reaction de cyclocondensation 2+2. L'etude bibliographique presentee dans le premier chapitre nous a permis de faire le point sur les differentes methodes de synthese de macrocycles polyheteroatomiques phosphores, silicies et bores. Dans le second chapitre de cette these, nous decrivons la preparation de nouveaux precurseurs phosphores de macrocycles. Le troisieme chapitre decrit la mise au point de deux voies de synthese permettant l'acces aux premiers macrocycles tetraphosphores fonctionnalises ou non, contenant des atomes de phosphore intracycliques a environnement n-p-n et o-p-o. La synthese de macrocycles phosphores possedant des heteroelements des groupes 13 et 14 tels que le silicium et le bore dans la chaine macrocyclique est egalement decrite dans ce chapitre. Enfin quelques aspects de la reactivite et des proprietes de complexation des precurseurs phosphores synthetises dans le second chapitre de ce memoire seront abordes dans cette quatrieme partie. Des complexes macrocycliques ou non du nickel, zirconium, titane et baryum seront decrits. Des monocristaux ont pu etre isoles dans le cas de certains complexes du nickel. L'etude des structures par diffraction de rx sera developpee

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Watson, Walter Philip. "Hybrid Macrocycles for Supramolecular Assemblies." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6958.

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Hybrid macrocycles, which chimerically integrate multiple chemical compositions and architectures, provide an effective way to impart new properties to polymers that are not found in their linear or homocyclic analogues. This dissertation addresses the incorporation of hydrophilic blocks into hydrophobic polymer, as either a poly(dimethyl siloxane)-block-poly(oxyethylene) (PDMS-POE) tadpole with a hydrophobic head and a hydrophilic tail or as a diblock poly(styrene)-block-diethylene glycol (PS-DEG) hydrophobic-hydrophilic macrocycle. The supramolecular association properties of both kinds of cycles were studied: the PDMS-POE tadpoles in forming micelles, and the PS-DEG macrocycles in threading with linear polymer to form polyrotaxanes. For the PDMS-POE macrocycle, linear alpha,omega-dihydroxy PDMS was cyclized under dilute conditions with dichloromethylhydrosilane as a linking group to produce hydrosilane-functionalized cyclic PDMS. This was joined to alpha-methoxy,omega-allyl POE via a free radical hydrosilylation reaction to produce the hybrid tadpole macrocycle, which was analyzed by GPC, DSC, and 1H, 13C, and 29Si NMR spectroscopy. Supramolecular aggregation consisting of the formation of micelles under both polar and nonpolar conditions was studied by surface tensiometry and quasielastic light scattering. For the PS-DEG macrocycle, linear alpha,omega-dihydroxy PS was prepared by ATRP polymerization of styrene, followed by reaction with KOH to give hydroxyl endgroups. The linear PS was then cyclized under dilute conditions with diethylene glycol ditosylate, and the product was analyzed by GPC, MALDI-TOF MS, DSC, and 1H, 13C and DOSY NMR spectroscopy. The macrocycle was then statistically threaded with linear PS to give the supramolecular structure poly(styrene)-rotaxa-cyclo[poly(styrene)-block-diethylene glycol]. Characterization was performed with DOSY NMR to verify that the product was threaded, and 1H NMR was collected to determine that the product was 13% macrocycle by weight. DSC showed only one Tg, indicating that the linear and cyclic species were present in the same phase.

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Morphy, John Richard. "Functionalised macrocycles for tumour targeting." Thesis, Durham University, 1988. http://etheses.dur.ac.uk/6407/.

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Monoclonal antibodies which recognise tumour-associated antigens provide a means of targeting radionuclides selectively to tumour cells. (^99m)Tc and (^64)Cu are potentially useful isotopes for radioimmunoimaging;(^ 90)Y and (^67)Cu may be suitable for radioimmunotherapy. The synthesis of functionalised macrocycles for binding these four radioisotopes to antibodies is described. In each case, a macrocycle has been selected to provide a complex which is kinetically inert, thereby preventing dissociation of the radiolabel in vivo. A novel strategy for conjugating a C-alkylated cyclam derivative (for binding Tc and Cu) to an antibody is described. This method facilitates the selective acylation of an exocyclic primary amino group in the presence of the secondary ring nitrogens. Unfortunately, the labelling of antibody-bound cyclam with (^99m)Tc required conditions (pH 11) which produced extensive binding of the radiolabel to the protein backbone. "Non-specific" (^99m) Tc was subsequently found to dissociate in vivo. Pre-labelling the macrocycle with (^99m)Tc solved the "non-specifics" problem but required a pH which meant that the conjugation step was too slow for sufficient specific activity to be bound. A phenol-pendent derivative of cyclam was found to incorporate (^99m)Tc at a lower pH than cyclam itself. The "non-specific" binding of copper to the protein was minimised using a low pH labelling strategy in conjunction with a chelate wash. Macrocycle antibody conjugates labelled manner provide very promising biodistribution profiles in normal mice. A labelling buffer was selected to enhance the rate of uptake of copper by the macrocycle at low pH. Macrocycle-antibody conjugates containing 13N(_4), which was found to provide faster association kinetics than cyclam, have been prepared and await radiolabelling studies. A derivative of I3N(_4), containing 4 carboxylic acid donor sites, has been functionalised for conjugation to an antibody to act as a (^90)Y binder.

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Wood, Ian. "Hydrogen bonded double helical macrocycles." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285635.

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Più fonti

Libri sul tema "Macrocycles"

Davis, Frank, and Séamus Higson. Macrocycles. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9780470980200.

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E, Weber, Vögtle F. 1939-, and Burrell A. K, eds. Macrocycles. Berlin: Springer-Verlag, 1992.

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Coppock, Matthew B., and Alexander J. Winton, eds. Peptide Macrocycles. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1689-5.

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Bradshaw, J. S. Aza-crown macrocycles. New York: Wiley, 1993.

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Levin, Jeremy, ed. Macrocycles in Drug Discovery. Cambridge: Royal Society of Chemistry, 2014. http://dx.doi.org/10.1039/9781782623113.

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Kim, Kimoon, ed. Cucurbiturils and Related Macrocycles. Cambridge: Royal Society of Chemistry, 2019. http://dx.doi.org/10.1039/9781788015967.

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Marsault, Eric, and Mark L. Peterson, eds. Practical Medicinal Chemistry with Macrocycles. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.

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Vögtle, Fritz, and Edwin Weber, eds. Host Guest Complex Chemistry / Macrocycles. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70108-5.

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Ball, Melissa Lynne. Conjugated Macrocycles in Organic Electronics. [New York, N.Y.?]: [publisher not identified], 2019.

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Campbell, Paul James. Towards macrocycles with interactive functional groups. Birmingham: University ofBirmingham, 1994.

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Capitoli di libri sul tema "Macrocycles"

Yao, Huan, and Wei Jiang. "Naphthol-Based Macrocycles." In Handbook of Macrocyclic Supramolecular Assembly, 975–95. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2686-2_40.

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Yao, Huan, and Wei Jiang. "Naphthol-Based Macrocycles." In Handbook of Macrocyclic Supramolecular Assembly, 1–21. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1744-6_40-1.

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Mamedov, Vakhid A. "Synthesis of Quinoxaline Macrocycles." In Quinoxalines, 271–342. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29773-6_5.

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Wessjohann, Ludger A., Ricardo A. W. Neves Filho, Alfredo R. Puentes, and Micjel Chávez Morejón. "Macrocycles from Multicomponent Reactions." In Practical Medicinal Chemistry with Macrocycles, 339–76. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch14.

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Masson, Géraldine, Luc Neuville, Carine Bughin, Aude Fayol, and Jieping Zhu. "Multicomponent Syntheses of Macrocycles." In Topics in Heterocyclic Chemistry, 1–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/7081_2010_47.

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Sellers, Benjamin D., Brian R. Hearn, Katerina Leftheris*, and Jennifer X. Qiao. "MACROCYCLES IN DRUG DISCOVERY." In Medicinal Chemistry Reviews, 333–60. Washington, DC: MEDI, Inc. Published by American Chemical Society., 2024. http://dx.doi.org/10.1021/mc-2024-vol59.ch15.

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Wessjohann, Ludger A., Ricardo A. W. Neves Filho, Alfredo R. Puentes, and Micjel C. Morejon. "Macrocycles from Multicomponent Reactions." In Multicomponent Reactions in Organic Synthesis, 231–64. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527678174.ch09.

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Chio, Weng-I. Katherine, and Tung-Chun Lee. "Host–Guest Chemistry of Macrocycles." In Macrocycle-Functionalised Nanosensors, 27–52. New York: Jenny Stanford Publishing, 2024. http://dx.doi.org/10.1201/9781003510574-2.

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Ronson, Thomas O., William P. Unsworth, and Ian J. S. Fairlamb. "Palladium-Catalyzed Synthesis of Macrocycles." In Practical Medicinal Chemistry with Macrocycles, 281–305. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch12.

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Wessjohann, Ludger A., Richard Bartelt, and Wolfgang Brandt. "Natural and Nature-Inspired Macrocycles." In Practical Medicinal Chemistry with Macrocycles, 77–100. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119092599.ch4.

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Atti di convegni sul tema "Macrocycles"

Rajan, K. S., P. Sen, E. J. Vesely, S. Verma, V. S. Agarwala, and A. A. Conte. "Macrocyclic Compounds for Corrosion-Wear." In CORROSION 1990, 1–13. NACE International, 1990. https://doi.org/10.5006/c1990-90444.

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Abstract The possible application of Schiff base compounds as corrosion- and wear-protective additives in lubricant formulations suitable for use at high temperatures (i.e., ≥200 °C) has been investigated. In addition to their planar structure and quadridentate metal-binding characteristics similar to those of the macrocyclic compounds such as the phthalocyanines and porphyrins, the Schiff base compounds exhibit appropriate thermal stabilities. Lubricant formulations using selected Schiff base compounds, phthalocyanines and porphyrins were prepared and tested for their corrosion protection and wear resistance characteristics using a specially-designed highspeed bearing test unit (HSBT).

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Hettiarachchi, S., Y. W. Chan, R. B. Wilson, and V. S. Agarwala. "Macrocyclic Corrosion Inhibitors for Steel in Acid Chloride Environments." In CORROSION 1987, 1–10. NACE International, 1987. https://doi.org/10.5006/c1987-87223.

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Abstract The effectiveness of phthalocyanines as acid corrosion inhibitors for steel have been studied. Water soluble tetrasulfophthalocyanines are very poor corrosion inhibitors. Water insoluble tetraaminophthalocyanines serve as better corrosion inhibitors than the water soluble ones when the metal surface is coated with an adsorbed layer of the phthalocyanine. The inhibitor efficiency was still far too low to be of any significance. Water insoluble polymeric phthalocyanine coatings based on Fe(III) centers gave inhibitor efficiencies as high as 82%, as confirmed by both slow potentiodynamic technique and the AC impedance analysis. The polymerization was achieved by simple dip coating followed by heat treatment of the coated surface at 450°C in an inert atmosphere. The resulting coating is adherent and electrically conducting thereby providing a unique set of conducting polymer inhibitors that can be used in acid environments. Experiments are in progress to develop polymer coatings with very low void fraction that will provide better anchoring onto the metal surface.

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Janak, Kevin E., Steven Colby, Tre Bertrand, and Brittany Fontenot. "Development of an Asphaltene Deposit Cleaning Technology Using a QCMB Technique." In CORROSION 2019, 1–10. NACE International, 2019. https://doi.org/10.5006/c2019-12821.

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Absrract Asphaltenes are a components of crude oil defined as a solubility class, i.e., as a component of crude oil insoluble in n-pentane (C5 asphaltenes) or n-heptane (C7 asphaltenes) but soluble in aromatic solvents such as toluene, and are complex, polyaromatic, macrocyclic structures with an overall varied composition. Asphaltene deposition, remediation, and inhibition are important considerations for flow assurance in upstream processes, but methodologies to assess performance for cleaning purposes can provide variable results. We report on the development of a dispersant additive for aromatic solvent systems using a QCMB technique for evaluating the cleaning of a deposit. Further, we report the performance of the additive in a case study and, hence, the utility of the technique to provide an assessment for potential field use.

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Shutalev, Anatoly, Anastasia Fesenko, Dmitry Albov, Vladimir Chernyshev, and Ilia Zamilatskov. "Novel 14-Membered Hexaaza Macrocycles." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a042.

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Gill, Hubert S., Michael Harmjanz, and Michael J. Scott. "Porphodimethenes/porphyrins: redox-switchable tetrapyrrolic macrocycles." In Complex Adaptive Structures, edited by William B. Spillman, Jr. SPIE, 2001. http://dx.doi.org/10.1117/12.446774.

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Ortiz-Jimenez, Orlando, Mónica Trejo-Durán, Edgar Alvarado-Méndez, Israel Severiano-Carrillo, and Egla Bivian-Castro. "Macrocycles in sol-gel matrix: nonlinear optical characterization." In SPIE Nanoscience + Engineering, edited by Stefano Cabrini, Gilles Lérondel, Adam M. Schwartzberg, and Taleb Mokari. SPIE, 2016. http://dx.doi.org/10.1117/12.2238228.

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Dimova, Iva. "STUDY OF STRENGTH TRAINING IN FEMALE 400 m SPRINT EVENT IN AGE ASPECT." In INTERNATIONAL SCIENTIFIC CONGRESS “APPLIED SPORTS SCIENCES”. Scientific Publishing House NSA Press, 2022. http://dx.doi.org/10.37393/icass2022/07.

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ABSTRACT Studying the different aspects of 400 m sports preparation is a key factor for the proper development of sports results. Strength training is one of the main pillars of sprint running. The object of the study is sports training of athletes in the 400 m sprint, and in particular strength training. The subject is the content and volume of the annual preparation for different age groups. We used the following methods: sports-pedagogical and technical-tactical analysis of athletes; interviews with coaches and athletes; Case-study analysis; Mathematical and statistical methods. A total of 58 macrocycles were analyzed: 16 macrocycles for under 18 years, 20 macrocycles for under 20 years, 22 macrocycles for women. We made a classification of the used exercises according to the main factors of sports achievement. We found a difference in the variety of exercises applied for different age groups. Girls under 18 years have a larger set of auxiliary exercises for strength training compared to women who have less variety but increased tonnage in weight training. We established minimum, maximum and average volume values of the various means in macro-, meso- and microcycles, according to age groups. In conclusion, we can note the lack of current scientific and methodological developments related to the selection and application of a specific volume of different means during stages of sports preparation, motivated us to bring out our study and represent relevant information for the volume and diversity of used athletic means. The dynamic development of track and field preparation has to constantly update, change and improve. The study of preparation variations that are known to be successful and efficient brings valuable theoretical information that can be used in the future. Systematization of data from the practice and indication of the basic volumetric parameters of training means for strength training in the 400 m run, will help for more purposeful preparation.

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Rella, R., L. Valli, and F. Chetta. "Optical sensing through wide delocalised macrocycles by SPR technique." In Proceedings of the 6th Italian Conference. WORLD SCIENTIFIC, 2001. http://dx.doi.org/10.1142/9789812810779_0012.

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Kepenekian, Mikael, Auguste Tetenoire, Arnaud Fihey, and Corinne Lagrost. "Covalent anchoring of macrocycles on metallic nanoparticles for electrocatalysis." In MATSUS Spring 2025 Conference. València: FUNDACIO DE LA COMUNITAT VALENCIANA SCITO, 2024. https://doi.org/10.29363/nanoge.matsusspring.2025.197.

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Leif, Robert C., Margie C. Becker, Lidia M. Vallarino, John W. Williams, and Sean Yang. "Progress in the use of Quantum Dye Eu(III)-macrocycles." In Biomedical Optics 2003, edited by Dan V. Nicolau, Joerg Enderlein, Robert C. Leif, and Daniel L. Farkas. SPIE, 2003. http://dx.doi.org/10.1117/12.486324.

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Rapporti di organizzazioni sul tema "Macrocycles"

van Swol, Frank B., and Craig John Medforth. Structural simulations of nanomaterials self-assembled from ionic macrocycles. Office of Scientific and Technical Information (OSTI), October 2010. http://dx.doi.org/10.2172/1008138.

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Root, Harrison Duane. Applications of Porphyrinoid Macrocycles in Molecular Sensing and f-Element Coordination. Office of Scientific and Technical Information (OSTI), June 2020. http://dx.doi.org/10.2172/1635507.

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McKenna, Gregory, Julia Kornfield, and Judit Puskas. Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), February 2023. http://dx.doi.org/10.2172/1971136.

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Puskas, Judit. Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), February 2023. http://dx.doi.org/10.2172/2203196.

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Allcock, Harry R. Strained Inorganic Heterocyclic Compounds and their Conversion to Macrocycles and High Polymers. Fort Belvoir, VA: Defense Technical Information Center, October 1991. http://dx.doi.org/10.21236/ada241414.

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Puskas, Judit, Gregory McKenna, and Julia Kornfield. Collaborative Research: Polymer Macrocycles: A novel topology to control dynamics of rubbery materials. Office of Scientific and Technical Information (OSTI), June 2019. http://dx.doi.org/10.2172/1654432.

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Eyring, Edward M., and Sergio Petrucci. Rates and Mechanisms of Complexation Reactions of Cations with Crown Ethers and Related Macrocycles. Fort Belvoir, VA: Defense Technical Information Center, January 1989. http://dx.doi.org/10.21236/ada203436.

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Klumpp, Doug Allen. The intramolecular cyclization of bis-2,5-dimethylene-2,5-dihydrofurans and bis-2,5-dimethylene-2,5-dihydrothiophenes: An approach to macrocycles. Office of Scientific and Technical Information (OSTI), January 1994. http://dx.doi.org/10.2172/10125330.

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Potts, K. Macrocyclic ligands for uranium complexation. Office of Scientific and Technical Information (OSTI), April 1990. http://dx.doi.org/10.2172/7201376.

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