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Tesi sul tema "Matrix metalloproteinase 1 (MMP1)"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 8 febbraio 2022

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1

Kumar, Deepak. "Mechanism of induction of matrix metalloproteinase-1 (MMP-1) during osteoarthritis /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144432.

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2

Sroka, Isis Calsoyas. "Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194830.

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Membrane type-1 matrix metalloproteinase (MT1-MMP) is a metalloproteinase which becomes upregulated in prostate cancer and has been implicated in processes of prostate cancer metastasis. Here, we show that MT1-MMP is minimally expressed in nonmalignant primary prostate cells, moderately expressed in DU-145 cells, and highly expressed in invasive PC-3 and PC-3N cells. Using MT1-MMP promoter reporters and mobility shift assays, we show that Sp1 regulates MT1-MMP expression in DU-145, PC-3, and PC-3N cells and in PC3-N cells using chromatin immunoprecipitation analysis and silencing RNA. Invest

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3

Anand, Monika. "FUNCTION AND REGULATION OF MATRIX METALLOPROTEINASE-1 IN GLIOBLASTOMA MULTIFORME." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2214.

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Glioblastoma Multiforme (GBM) is an aggressive and fatal cancer of the brain. It is characterized with augmented morbidity and elusion to therapies due in part to the incessant infiltration and spread of tumor cells in normal brain. We investigated the function of Matrix metalloproteinase-1, an important enzyme noted to be responsible for invasion in other cancers, in GBM and its regulation by epidermal growth factor receptor (EGFR) signaling. Previous studies from our laboratory demonstrated elevated levels of MMP-1 in GBM. Further studies indicated the involvement of MMP-1 in GBM invasio

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4

Mullet, Emily. "Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1437.

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5

Nguyen, Khanh Vu Thuy. "The Effects of Scaling and Root Planing on the Systemic Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1)." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/160.

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Balance between matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) is required for normal wound healing. Chronic inflammation, such as that seen in cardiovascular and periodontal diseases, may upset this balance. The aim of this study was to determine whether initial periodontal therapy would have an effect systemically on the levels of MMP-9 and TIMP-1. Twenty-one patients with generalized chronic periodontitis were enrolled in the study. Clinical examinations were conducted and parameters measured. Scaling and root planing was performed and blood a

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6

Arnold, Laurence. "Biophysical characterisation of collagen binding by the hemopexin domain of matrix metalloproteinase-1 (MMP-1)." Thesis, University of Portsmouth, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516871.

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7

Li, He. "A study of fibroblast-mediated contraction in ocular scarring : gene expression profiling and the role of small GTPases in Matrix Metalloproteinase 1 (MMP1) regulation." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10024949/.

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Understanding the molecular mechanisms involved in fibroblast-mediated tissue contraction is essential for developing future therapeutics for anti-scaring and fibrosis treatment not only for eyes, but also for a wide range of fibrotic diseases. The small Rho GTPase Rac1 is a master regulator of actin dynamics, which plays an essential role in protrusive activity, tissue repair and wound healing. A genome wide microarray study was performed with/without the transient treatment of human conjunctival fibroblasts with Rac1 inhibitor NSC23766 in a collagen gel contraction model to unveil the signal

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8

Sritharan, Kajanatharshni. "The role of membrane type-1 matrix metalloproteinase (MT1-MMP) in carotid plaque instability." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517390.

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9

Wang, Fang St George Clinical school UNSW. "Oxidative stress induced C-Jun N-terminal Kinase (JNK) activation in tendon cells upregulates MMP1 mRNA and protein expression." Awarded by:University of New South Wales. St George Clinical school, 2006. http://handle.unsw.edu.au/1959.4/28815.

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To explore the potential mechanisms of tendon degeneration, we investigated the role of c-Jun N-terminal Kinase (JNK) activation and the regulation of matrix metalloproteinase 1 (MMP1) in tendon matrix degradation under oxidative stress. JNK and MMP1 activity in samples from normal and ruptured human supraspinatus tendons were evaluated by immunohistochemistry. Real-time quantitative PCR was utilized to evaluate MMP1 mRNA expression and western blotting for MMP1 and JNK protein detection. JNK activation and increased MMP1 activity were found in the torn human supraspinatus tendon tissue, as we

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10

Harada, Tomika. "Membrane-type matrix metalloproteinase-1(MT1-MMP) gene is overexpressed in highly invasive hepatocellular carcinomas." Kyoto University, 1999. http://hdl.handle.net/2433/181703.

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11

Zinzindohoue, Franck. "Influence de deux polymorphismes nucléotidiques fonctionnels des régions promotrices des gènes de MMP-1 (-1607ins/delG) et de MMP-3 (-1612ins/delA) au cours des cancers ORL et des cancers colorectaux." Paris 5, 2005. http://www.theses.fr/2005PA05S021.

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Nous avons étudié l'influence des polymorphismes nucléotidiques fonctionnels des régions promotrices de MMP-1 (-1607ins/delG) et de MMP-3 (-1612ins/delA). Nous avons montré dans une étude cas-témoin de cancers ORL, que les homozygotes MMP-1 -1607delG avaient un risque significativement plus élevé de cancer ORL. Dans une seconde étude, nous avons montré la valeur prédictive du polymorphisme de MMP-3 sur la réponse à la chimiothérapie néoadjuvante associant 5 FU - cisPt. Dans une troisième étude sur des malades atteints de cancers colorectaux, les homozygotes pour l'allèle MMP-1 1607insG stades

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12

Vasala, K. (Kaija). "Matrix metalloproteinase MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 in bladder carcinoma." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514288746.

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Abstract Bladder cancer when superficial has a good prognosis but it has a high recurrence risk and about 10–15% of the superficial carcinomas will progress into muscle invasive or metastatic type. The most powerful factor for predicting the behavior of bladder carcinoma is the stage of the tumor. Invasion to the lamina propria increases the risk of recurrence and progress to muscle-invasive tumor. Also grade of the tumor and tumor multiplicity associates with high risk for recurrence. New markers are still needed to find those patients who need more and better treatments to avoid the recurren

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13

Kormi, I. (Immi). "Translational perspectives on matrix metalloproteinase 8 and other inflammatory biomarkers in cardiovascular diseases." Doctoral thesis, Oulun yliopisto, 2017. http://urn.fi/urn:isbn:9789526215297.

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Abstract Cardiovascular diseases (CVD), and especially atherosclerotic vascular diseases (ASVD), are the largest cause of morbidity and premature death worldwide. Coronary heart disease (CHD) and cerebrovascular disease (stroke) are common and severe manifestations of ASVD. Atherosclerosis is a chronic inflammatory disease and lipoprotein metabolism disorder. If the regulation of inflammatory process is disturbed, the systemic release of pro-inflammatory mediators, including matrix metalloproteinases (MMPs), may lead to a low-grade systemic inflammation, which is a risk factor for CVDs. MMPs a

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14

Farooqi, Owais Ali. "Effect of methamphetamine on gingival fibroblast production of matrix metalloproteinase (MMP)-2 and -9 and tissue inhibitor of metalloproteinase (TIMP)-1 and -2 in vitro." View the abstract Download the full-text PDF version, 2009. http://etd.utmem.edu/ABSTRACTS/2009-023-Farooqi-index.htm.

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Thesis (M.S.)--University of Tennessee Health Science Center, 2009.<br>Title from title page screen (viewed on August 5, 2009). Research advisor: David A. Tipton, D.D.S., Ph.D. Document formatted into pages (vi, 39 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 27-38).

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15

Bednarek, Nathalie. "Mmp-2, -9, timp-1, -2 : recherche de biomarqueurs de lésions cérébrales chez l'enfant prématuré et à terme." Paris 7, 2008. http://www.theses.fr/2008PA077103.

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Les atteintes cérébrales périnatales sont une cause majeure de décès ou de handicap. TJôtre hypothèse est que les MMP-2 et -9 et les TIMP-1, -2 pourraient être des marqueurs précoces de ces lésions cérébrales. Le profil cortical des MMP-2, -9, TIMP-1 et -2 a été étudié de la vie embryonnaire à l'âge adulte. Les profils plasmatiques de nouveaux-nés ont été étudiés en fonction de l'âge gestationnel, du sexe et des pathologies rencontrées en période néonatale. Le profil des MMP-2, -9, TIMP-1 et -2 ont été étudiés au niveau du cortex et du plasma dans des modèles animaux. MMP-2, leTIMP-1 et le TIM

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16

Honkavuori-Toivola, M. (Maria). "The prognostic role of matrix metalloproteinase-2 and -9 and their tissue inhibitor-1 and -2 in endometrial carcinoma." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204505.

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Abstract Endometrial carcinoma is the most common gynegologic malignancy in developed countries. Due to early symptoms, including abnormal uterine bleeding, endometrial cancer is often diagnosed at an early stage and in that case usually has a good prognosis and high cure rates. However, the nature of the disease is heterogeneous. During the last decades, the improvement in survival rates among endometrial cancer patients has not been significant, suggesting that the traditional clinicopathological factors may be inadequate to identify patients with high-risk disease. Furthermore, aggressive a

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17

Westin, Maria Cristina do Amaral 1949. "Expressão das proteínas MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 e VEGF-A na NIC 3 e no carcinoma invasor do colo do útero = Expression of the proteins MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2 and VEGF-A in the CIN 3 and cervical cancer." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313599.

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Orientadores: Luiz Carlos Zeferino, Silvia Helena Rabelo dos Santos<br>Texto em português e inglês<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-23T06:30:30Z (GMT). No. of bitstreams: 1 Westin_MariaCristinadoAmaral_D.pdf: 3122088 bytes, checksum: 3d2afed3690cd3566bbb3fe26bb492a3 (MD5) Previous issue date: 2013<br>Resumo: Introdução: O carcinoma escamoso do colo uterino é precedido pela neoplasia intraepitelial cervical grau 3 (NIC 3). A invasão tumoral envolve a degradação da matriz extracelular e membrana basal

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18

Mazzone, Marco. "Role of intracellular transport, sorting and release of membrane type 1 matrix metalloproteinase (MT1-MMP) in tumor cell invasion and metastic dissemination." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422024.

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19

Solotskaya, Anna. "NEUTROPHIL PRODUCTS CONTROL THE EXPRESSION OF PROGESTERONE RECEPTORS AND MATRIX METALLOPROTEINASE-1 IN THE DECIDUAL AND MYOMETRIUM AND ARE POSSIBLE REGULATORS OF PREMATURE LABOR." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2112.

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Neutrophils infiltrate myometrium and decidual tissue prior to parturition. Activated neutrophils release reactive oxygen species (ROS) and tumor necrosis factor α (TNFα), which might increase expression of pro-labor genes such as matrix metalloproteinase-1 (MMP-1), progesterone receptor (PR) A/B ratio, and cause demethylation of DNA. These changes might cause labor. Decidual tissue was obtained from consented, healthy women at term (37+ weeks of gestation) not in labor (no contractions, without cervical effacement), term labor and preterm labor (under 37 weeks of pregnancy). Decidual and myo

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20

Ruokolainen, H. (Henni). "The prognostic role of matrix metalloproteinase -2 and -9 (MMP-2, MMP-9) and their tissue inhibitors -1 and -2 (TIMP-1, TIMP-2) in head and neck squamous cell carcinoma." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514279174.

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Abstract Traditional clinicopathological factors are not accurate enough to predict the behavior of head and neck squamous cell carcinoma (HNSCC). The most powerful indicator of prognosis is the stage of the disease. New prognostic markers have, however, been searched for in order to better identify patient groups in need of different treatments or follow-up. Gelatinases (MMP-2, -9) are endopeptidases associated with tumor invasion and angiogenesis, and their tissue inhibitors (TIMP-1, -2) are also linked to cancer cell invasion and metastasis formation. In some cancer types they are even prog

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21

Miki, Takao. "The reversion-inducing cysteine-rich protein with Kazal motifs (RECK) interacts with membrane type 1 matrix metalloproteinase (MT1-MMP) and CD13/aminopeptidase N (APN), and modulates their endocytic pathways." Kyoto University, 2007. http://hdl.handle.net/2433/135757.

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22

Meschiari, César Arruda. "Concentrações de MMP-8, MMP-9, MPO, TIMP-1 e TIMP-2 na saliva e correlações com plasma." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-12032012-110848/.

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Metaloproteinases da matriz extracelular (MMPs) são uma família de endopeptidases zinco-dependentes conhecidas por degradar componentes do tecido conjuntivo em processos fisiológicos e patológicos. A regulação da atividade das MMPs pode ser feita pelos inibidores teciduais de metaloproteinases (TIMPs). A doença periodontal (DP) é a inflamação crônica em que atividade excessiva das MMPs e mieloperoxidase (MPO) são apontadas como responsáveis pela destruição dos tecidos suporte dos dentes. Os componentes da saliva são derivados da vascularização local sendo possível encontrar neste fluido o refl

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23

Seabra, Fl?vio Roberto Guerra. "An?lise imuno-histoqu?mica das metaloproteinases da matriz ( MMP-1,MMP-2 e MMP-9) na doen?a periodontal." Universidade Federal do Rio Grande do Norte, 2006. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17147.

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Made available in DSpace on 2014-12-17T15:32:29Z (GMT). No. of bitstreams: 1 FlavioRGS.pdf: 1482227 bytes, checksum: b9834cd77c4a705b90b0a7430780fd14 (MD5) Previous issue date: 2006-09-19<br>The tissular destruction found in periodontal diseases is caused mainly by components of the host that have its production stimulated by the products of the microorganisms present on the plaque. Matrix Metalloproteinases (MMPs), a class of enzymes involved both in physiologic and pathologic extracellular matrix degradation are considered the main responsible for the characteristic tissular loss in period

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24

Juliasse, Luiz Eduardo Rodrigues. "Estudo da express?o imuno-histoqu?mica das prote?nas MMP-9, MMP-13 e TIMP-1 em ameloblastomas e tumores odontog?nicos ceratocistos." Universidade Federal do Rio Grande do Norte, 2014. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17136.

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Made available in DSpace on 2014-12-17T15:32:24Z (GMT). No. of bitstreams: 1 LuizERJ_DISSERT.pdf: 1737074 bytes, checksum: 8941b0b8844e6080e5a540ee05d65531 (MD5) Previous issue date: 2014-02-28<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Ameloblastomas and keratocystic odontogenic tumors (KOT) represent odontogenic lesions that, despite their benign nature, are distinguished by a distinct biological behavior, characterized by locally aggressive growth and recurrent episodes. The gnathic bone resorption caused by the growth of these lesions is a key to the expansion of

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Butt, Louise. "Structure-function relationships in matrix metalloproteinase-1." Thesis, University of Portsmouth, 2013. https://researchportal.port.ac.uk/portal/en/theses/structurefunction-relationships-in-matrix-metalloproteinase1(2b3318eb-8f07-48ab-8b00-b77a1e069d71).html.

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Collagenolysis, the catabolism of triple helical collagen, is essential for the physiological remodeling of connective tissues during growth and development. Aberrant collagen degradation is a feature of both inflammatory diseases and cancer cell invasion. Matrix metalloproteinase-1 (MMP-1) is a known collagenase and previous studies have implicated its hemopexin (HPX) domain in binding and possibly destabilising collagen in preparation for hydrolysis by the catalytic (CAT) domain. More recently, conformational freedom and domain separation of the CAT and HPX domains has been proposed to play

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26

Cox, Kathryn Elizabeth. "Matrix metalloproteinase-3 in uterus and endometriosis." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012963.

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27

Justulin, Junior Luis Antonio. "Efeitos da doxazosina e da combinação doxasina mais finasterida sobre a interação parenquina-estroma na prostata de rato : proliferação, morte celular, atividade das MMPs-2 e 9 e expressão genica dos TIMPs 1 e 2." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317949.

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Orientador: Sergio Luis Felisbino<br>Tese (doutorado) - Universidade Estadual de Campinas, Insituto de Biologia<br>Made available in DSpace on 2018-08-13T04:30:25Z (GMT). No. of bitstreams: 1 JustulinJunior_LuisAntonio_D.pdf: 17091914 bytes, checksum: 15d52dabcde65a4f842895fd71f92ccd (MD5) Previous issue date: 2008<br>Resumo: Finasterida (Fin), um inibidor da enzima 5a-redutase do tipo II e a Doxazosina (Dox), um inibidor do receptor a1-adrenérgico, tem sido amplamente utilizados no tratamento dos sintomas da Hiperplasia Prostática Benigna (HPB). Recentemente, dados clínicos demonstraram que

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Pullen, Nicholas. "THE INFLUENCES OF MATRIX METALLOPROTEINASE-1 EXPRESSION ON GLIOBLASTOMA PATHOLOGY." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2037.

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Glioblastoma multiforme (GBM) is an aggressive central nervous system (CNS) cancer characterized by enhanced tumor cell motility, pernicious invasion into the normal brain, extensive tumor-induced angiogenesis, and adaptive resistance to current therapeutic paradigms. One of the difficulties associated with GBM is the ability of the tumor cells to infiltrate normal CNS tissue. Neurosurgeons can remove the primary tumor mass, but peripheral cells that are inaccessible will ultimately result in a secondary lesion that can lead to death. The matrix metalloproteinases (MMP) are well known for

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29

Kuvaja, P. (Paula). "The prognostic role of matrix metalloproteinases MMP-2 and -9 and their tissue inhibitors TIMP-1 and -2 in primary breast carcinoma." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285998.

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Abstract Breast carcinoma is a heterogeneous disease with a prognosis that varies from excellent to very poor. Traditional tumour parameters and biological factors that are also predictive for treatment response are used in determining breast carcinoma prognosis and selecting appropriate treatment. Gelatinases MMP-2 and MMP-9 have been shown to associate with tumour progression. Their tissue inhibitors TIMP-1 and -2 are multifunctional molecules that have been suggested as prognostic markers in some previous reports. In the present work, the expression and prognostic value of gelatinases MMP

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Lehti, Kaisa I. "Membrane-type-1 matrix metalloproteinase in pericellular proteolysis and cell migration." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/lehti/.

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Javaid, Mohammad. "Platelet factor 4 upregulates matrix metalloproteinase-1 production in gingival fibroblasts." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/60244.

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Background and Objective: Periodontitis is a highly prevalent chronic inflammatory disease that causes tooth loss, morbidity and confers an increased risk for systemic disease. Tissue destruction during periodontitis is due in large part to collagen-degrading matrix metalloproteinases (MMPs) released by resident cells of the periodontium in response to pro-inflammatory cytokines. Platelets are immune-competent blood cells with a newly recognized role in chronic inflammation, however their role in the pathogenesis of periodontitis is undefined. Consequently, the objective of this study was to a

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Labbene, Azza [Verfasser], and Nikolas [Akademischer Betreuer] Mirow. "Rolle der Matrix-Metalloproteinasen bei der Mitralklappeninsuffizienz: Assoziation zwischen der Expression von MMP-1, MMP-9, TIMP-1 und TIMP-2, dem Mitralinsuffizienzgrad und der Ätiologie / Azza Labbene ; Betreuer: Nikolas Mirow." Marburg : Philipps-Universität Marburg, 2019. http://d-nb.info/1199537500/34.

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Naveed, Shams-un-nisa. "Matrix metalloproteinase-1 mediated extra-cellular matrix remodelling contributes to airway smooth muscle growth and asthma severity." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50577/.

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Introduction Airway remodelling describes the histopathological changes in tissue architecture observed in obstructive lung diseases such as asthma and may have a negative impact on lung function. These changes do not appear to be treated by current asthma treatments. Changes observed during airway remodelling include increased thickness of airway smooth muscle (ASM) layer and enhanced extracellular matrix (ECM) deposition. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes, which facilitate tissue remodelling via ECM protein degradation. Matrix metalloproteinase-1 (MMP-1) an

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Falkenberg, Sonja. "Expression der Matrix-Metalloproteinasen MMP-2, -7, -9 und -13 und ihrer Inhibitoren TIMP-1, -2 und -3 in Plattenepithelkarzinomen des oberen Aerodigestivtraktes." [S.l.] : [s.n.], 2004. http://archiv.ub.uni-marburg.de/diss/z2004/0679/.

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Hussain, Shaista. "Signalling pathways implicated in the growth factor and cytokine mediated up regulation of gelantinase B, collagenase 1 and stromelysin-1 in rabbit aortic smooth muscle cells in vitro." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340275.

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Hartland, Stephen. "Mechanistic analyses of transforming growth factor-Î’-mediated repression of matrix metalloproteinase-1." Thesis, University of Newcastle Upon Tyne, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430407.

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Durkan, Garrett Christopher. "Matrix metalloproteinase-1 and -9 and tissue inhibitor of metalloproteinase-1 in bladder cancer : pathophysiological significance and relationship to epidermal growth factor receptor expression." Thesis, University of Newcastle Upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369832.

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Fischoeder, Arne [Verfasser]. "Regulation von Matrix Metalloproteinase-9 durch Insulin in humanen THP-1 Monozyten / Arne Fischoeder." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023784432/34.

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Shimizu, Makoto. "Hyaluronan Inhibits Matrix Metalloproteinase-1 Production by Rheumatoid Synovial Fibroblasts Stimulated by Proinflammatory Cytokines." Kyoto University, 2004. http://hdl.handle.net/2433/147561.

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Freitas, Val?ria Souza. "Estudo da express?o imuno-histoqu?mica das MMPs -2, -7, -9 e -26 e TIMPs -1 e -2 em adenomas pleom?rficos e carcinomas aden?ides c?sticos de gl?ndulas salivares menores." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/17149.

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Made available in DSpace on 2014-12-17T15:32:30Z (GMT). No. of bitstreams: 1 ValeriaSF_TESE.pdf: 1554906 bytes, checksum: 59273626aa3c7c32d790e22ae6dd68d4 (MD5) Previous issue date: 2011-02-24<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>The balance between the expression of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) has been related to various physiological and pathological processes, including salivary gland morphogenesis and tumor invasion and metastasis processes. Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) respectively rep

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Hovell, Christopher John. "Membrane-type 1 matrix metalloproteinase expression by hepatic stellate cells : its role in liver fibrosis." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322017.

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42

Medeiros, Mildred Ferreira. "Hanseníase neural, aspectos diagnósticos da forma neural pura e mecanismos imunopatogênicos da lesão do nervo na doença. Participação de quimiocinas CCL2 e CXCL10 e metaloproteinases 2 e 9." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=7356.

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Abstract (sommario):

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>O diagnóstico da hanseníase neural pura baseia-se em dados clínicos e laboratoriais do paciente, incluindo a histopatologia de espécimes de biópsia de nervo e detecção de DNA de Mycobacterium leprae (M. leprae) pelo PCR. Como o exame histopatológico e a técnica PCR podem não ser suficientes para confirmar o diagnóstico, a imunomarcação de lipoarabinomanana (LAM) e/ou Glicolipídio fenólico 1 (PGL1) - componentes de parede celular de M. leprae foi utilizada na primeira etapa deste estudo, na tentativa de detectar qualquer presença

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43

Koch, Sabine. "Die Expression und Aktivität von Matrix-Metalloproteinase-1 wird durch Stickstoffmonoxid, reduzierte Thiole und Zytokine reguliert." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=983272174.

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44

McCready, Jessica. "The Influence of a Single Nucleotide Polymorphism In The Matrix Metalloproteinase-1 Promoter on Glioma Biology." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1123.

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Glioblastomas are an incurable type of brain tumor with a mean survival time of 9-12 months following diagnosis. One of the reasons for this poor prognosis is the ability of tumor cells to invade the surrounding normal brain tissue. Enzymes responsible for this invasive nature include the matrix metalloproteinase family. MMP-1 is a member of this family which has been well studied in many types of invasive tumors, with gliomas being an exception. We studied a single nucleotide polymorphism (SNP) in the MMP-1 promoter that may influence glioma biology. This SNP consists of the presence (2G) or

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45

Pacheco, Fernández Natalia María [Verfasser], and Reinhard [Akademischer Betreuer] Fässler. "Nucleobindin-1 modulates extracellular matrix remodeling by promoting intra-Golgi trafficking of matrix metalloproteinase 2 / Natalia María Pacheco Fernández ; Betreuer: Reinhard Fässler." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1215499892/34.

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46

Prothero, Joanna. "Matrix metalloproteinase-3 (stromelysin-1) gene promoter polymorphism in relation to predisposition to inflammatory bowel disease (IBD)." Thesis, University of Southampton, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436934.

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47

Rauvala, M. (Marita). "Matrix metalloproteinases -2 and -9 and tissue inhibitors of metalloproteinases -1 and -2 in gynaecological cancers." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:951428187X.

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Abstract The invasion of a tumour through tissue limiting basement membranes is the critical step in malignant growth. Gelatinases (MMP-2 and MMP-9) are endopeptidases capable of degrading extracellular and pericellular matrix proteins such as collagen IV, the major component of basement membranes. An over-expression of these gelatinases is generally found in malignant tumours and is linked to impaired prognosis in many cancer types. Tissue inhibitors of metalloproteinases (TIMPs), endogenous regulators of the MMP activity, have recently been introduced as multifunctional proteins, which have

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48

Pradhan-Palikhe, P. (Pratikshya). "Matrix metalloproteinase-8 as a diagnostic tool for the inflammatory and malignant diseases." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295096.

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Abstract (sommario):

Abstract Matrix metalloproteinases (MMPs) are the zinc-dependent endopeptidases which belong to a large family of proteases. MMPs are responsible for degradation and remodeling of extracellular matrix proteins during growth, organogenesis and tissue turnover. Besides their role in physiological processes, MMPs also influence various pathological processes, i.e., inflammatory diseases and cancers, in which MMPs may ultimately lead to unwanted tissue destruction. One of the most widely studied MMPs is MMP-8. MMP-8 was previously thought to be expressed only by neutrophils. Presently, it is evide

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49

Walia, Baljit S. "Matrix metalloproteinase activation in heart failure due to volume-overloa and the effect of AT¦1 receptor blockade." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ45160.pdf.

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50

Yoshida, Masahiro. "Prostaglandin F2α, cytokines, and cyclic mechanical stretch augment matrix metalloproteinase-1 secretion from cultured human uterine cervical fibroblast cells". Kyoto University, 2004. http://hdl.handle.net/2433/147549.

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