Accedi

Bibliografie tematiche / Matrix metalloproteinase 1 (MMP1) / Articoli di riviste

Segui questo link per vedere altri tipi di pubblicazioni sul tema: Matrix metalloproteinase 1 (MMP1).

Articoli di riviste sul tema "Matrix metalloproteinase 1 (MMP1)"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 8 febbraio 2022

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Vedi i top-50 articoli di riviste per l'attività di ricerca sul tema "Matrix metalloproteinase 1 (MMP1)".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Vedi gli articoli di riviste di molte aree scientifiche e compila una bibliografia corretta.

1

Balasa, Rodica, Ciurba Bianca, Voidezan Septimiu, Simu Iunius, Hutanu Adina, Andone Sebastian, Romaniuc Andreea, Motataianu Anca, and Maier Smaranda. "The Matrix Metalloproteinases Panel in Multiple Sclerosis Patients Treated with Natalizumab: A Possible Answer to Natalizumab Non- Responders." CNS & Neurological Disorders - Drug Targets 17, no. 6 (August 28, 2018): 464–72. http://dx.doi.org/10.2174/1871527317666180703102536.

Testo completo

Abstract (sommario):

Background: In the lymphocyte migration across the blood-brain barrier (BBB) in multiple sclerosis (MS), matrix metalloproteinases (MMPs) play an important role in the degradation of the basal membrane. Natalizumab (NAT), a monoclonal antibody, binds to the alpha-4 (α4) integrin leading to BBB impermeability. Approximately 30% of NAT-treated patients show clinical or MRI signs of BBB disruption. Objective: To determine whether NAT significantly influences the MMPs serum levels and to what extent these could be used as biomarkers in relapsing-remitting MS (RRMS) patients. Materials and Methods:

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Skov, Vibe, Mads Thomassen, Lasse Kjær, Caroline Riley, Thomas Stauffer Larsen, Ole Weis Bjerrum, Torben A. Kruse, and Hans Carl Hasselbalch. "Extracellular Matrix-Related Genes Are Deregulated in Peripheral Blood from Patients with Myelofibrosis and Related Neoplasms." Blood 132, Supplement 1 (November 29, 2018): 5491. http://dx.doi.org/10.1182/blood-2018-99-117122.

Testo completo

Abstract (sommario):

Abstract Introduction: The Philadelphia-negative chronic myeloproliferative neoplasms (MPNs) which include essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are characterized by varying degrees of bone marrow fibrosis and endothelial proliferation. We and others have previously reported that these stromal alterations are reflected by increased serum levels of matrix derived metabolites, striated collagens type I/III and basement membrane components. The existence of a prefibrotic seromarker profile in MPNs is further evidenced by reports on increased serum

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Mogulevtseva, J. A., A. V. Mezentsev, and S. A. Bruskin. "RNAI-MEDIATED SILENCING OF MATRIX METALLOPROTEINASE 1 IN EPIDERMAL KERATINOCYTES INFLUENCES THE BIOLOGICAL EFFECTS OF INTERLEUKIN 17A." Vavilov Journal of Genetics and Breeding 22, no. 4 (July 3, 2018): 425–32. http://dx.doi.org/10.18699/vj18.378.

Testo completo

Abstract (sommario):

Matrix metalloproteinases (MMPs) are important for the pathogenesis of psoriasis and other autoimmune disorders. In the extracellular matrix, accumulation of proinflammatory cytokines, such as interleukin 17A (IL-17A), leads to induction of several MMPs, including MMP1. MMPs change the composition and other properties of the extracellular matrix. These changes facilitate tissue remodeling and promote the development of psoriatic plaques. The aim of this study was to explore how MMP1 silencing might influence the biological effects of IL-17A on migration and proliferation of human epidermal ker

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Chen, Chao, Congcong Li, Weichun Liu, Feng Guo, Xi Kou, Si Sun, Taiyang Ye, Shanji Li, and Aimin Zhao. "Estrogen-induced FOS-like 1 regulates matrix metalloproteinase expression and the motility of human endometrial and decidual stromal cells." Journal of Biological Chemistry 295, no. 8 (January 14, 2020): 2248–58. http://dx.doi.org/10.1074/jbc.ra119.010701.

Testo completo

Abstract (sommario):

The regulation mechanisms involved in matrix metalloproteinase (MMP) expression and the motility of human endometrial and decidual stromal cells (ESCs and DSCs, respectively) during decidualization remain unclear. DSCs show significant increased cell motility and expression of FOS-like 1 (FOSL1) and MMP1, MMP2, and MMP9 compared with ESCs, whereas lack of decidualization inducers leads to a rapid decrease in FOSL1 and MMP1 and MMP9 expression in DSCs in vitro. Therefore, we hypothesized that a link exists between decidualization inducers and FOSL1 in up-regulation of motility during decidualiz

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Zhang, Jianmei, Mi-Yeon Kim, and Jae Youl Cho. "Euodia pasteuriana Methanol Extract Exerts Anti-Inflammatory Effects by Targeting TAK1 in the AP-1 Signaling Pathway." Molecules 25, no. 23 (December 7, 2020): 5760. http://dx.doi.org/10.3390/molecules25235760.

Testo completo

Abstract (sommario):

Euodia pasteuriana A. Chev. ex Guillaumin, also known as Melicope accedens (Blume) T.G. Hartley, is a herbal medicinal plant native to Vietnam. Although Euodia pasteuriana is used as a traditional medicine to treat a variety of inflammatory diseases, the pharmacological mechanisms related to this plant are unclear. This study aimed to investigate the anti-inflammatory effects of a methanol extract of Euodia pasteuriana leaves (Ep-ME) on the production of inflammatory mediators, the mRNA expression of proinflammatory genes, and inflammatory signaling activities in macrophage cell lines. The res

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Zaidi, Sana Jafar, Nabeela Riaz, Asifa Iqbal, and Ayyaz Ali Khan. "Salivary Matrix Metalloproteinase (MMP)-1 as Non-Invasive Tool for The Diagnosis of Oral Squamous Cell Carcinoma (OSCC)." Journal of the Pakistan Dental Association 30, no. 1 (February 14, 2021): 18–23. http://dx.doi.org/10.25301/jpda.301.18.

Testo completo

Abstract (sommario):

OBJECTIVE: To determine the diagnostic accuracy of salivary MMP1 as non-invasive diagnostic biomarker of OSCC through conventional sandwich ELISA technique. Analytical cross-sectional study. METHODOLOGY: Individuals with clinical suspicion for OSCC (IWCS-OSCC) were included in the study after fulfilling selection criteria. Saliva samples were collected from IWCS-OSCC. To confirm OSCC, the patients were referred for biopsy. After definitive diagnosis on biopsy, patients were labeled OSCC positive or OSCC negative. The colorimetric sandwich-ELISA test was performed on saliva samples to measure t

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Korytina, G. F., L. Z. Akhmadishina, D. G. Yanbaeva, Sh Z. Zagidullin, and T. V. Viktorova. "Association of polymorphic variants of matrix metalloproteinase and antiprotease genes with development and severity of chronic obstructive pulmonary disease." PULMONOLOGIYA, no. 1 (February 28, 2008): 33–38. http://dx.doi.org/10.18093/0869-0189-2008-0-1-33-38.

Testo completo

Abstract (sommario):

To evaluate a role of polymorphic variants of metalloproteinase and protease genes for hereditary susceptibility to COPD and its severity, we analyzed polymorphic loci of MMP1, MMP9, MMP12, PI, and AACT genes in COPD patients (n = 318) and healthy persons (n = 319) living at the Bashkortostan Republic. Results showed that frequency of genotypes and alleles of G(-1607)GG gene MMP1, С(-1562)T gene MMP9, A(-82)G gene MMP12, and Ala 15 Thr gene ААСТ did not differ in COPD patients and healthy subjects. The Zand S-mutations of the PI gene were also similar in both the groups. The heterozygous GA ge

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Morais Junior, Gilberto Santos, Nathalia Oliveira Rodrigues, Adriane Dallanora Henriques, Audrey Cecília Tonet-Furioso, Ciro José Brito, Lucy Oliveira Gomes, Clayton Franco Moraes, and Otávio Toledo Nóbrega. "Matrix Metalloproteinase-1 Gene Polymorphism Associated with Ultrasound-Assessed Carotid Thickness among Older Adults." Journal of Aging Research 2018 (June 21, 2018): 1–6. http://dx.doi.org/10.1155/2018/1475890.

Testo completo

Abstract (sommario):

Background and Aim. Due to the high incidence of vascular diseases, it is necessary to identify new circulating or structural markers for predicting risk for chronic diseases. Some studies suggest that MMP1 gene polymorphisms are associated with the enzyme expression levels in situ (e.g., in atherosclerotic plaques). Objectives. Thus, the study of this polymorphism may help understanding the pathophysiology of coronary disease. Methods. We performed cross-sectional clinical and laboratory evaluations (including measurement of intima-media thickness of carotid arteries) and genotyping of the MM

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Said, Anan H., Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, and Jean-Pierre Raufman. "Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells." Biochemical Journal 474, no. 5 (February 20, 2017): 647–65. http://dx.doi.org/10.1042/bcj20160704.

Testo completo

Abstract (sommario):

M3 muscarinic receptor (M3R) expression is increased in colon cancer; M3R activation stimulates colon cancer cell invasion via cross-talk with epidermal growth factor receptors (EGFR), post-EGFR activation of mitogen-activated protein kinase (MAPK) extracellular signal-related kinase 1/2 (ERK1/2), and induction of matrix metalloproteinase-1 (MMP1) expression. MMP1 expression is strongly associated with tumor metastasis and adverse outcomes. Here, we asked whether other MAPKs regulate M3R agonist-induced MMP1 expression. In addition to activating ERK1/2, we found that treating colon cancer cell

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Sauter, Wiebke, Albert Rosenberger, Lars Beckmann, Silke Kropp, Kirstin Mittelstrass, Maria Timofeeva, Gabi Wölke, et al. "Matrix Metalloproteinase 1 (MMP1) Is Associated with Early-Onset Lung Cancer." Cancer Epidemiology Biomarkers & Prevention 17, no. 5 (May 2008): 1127–35. http://dx.doi.org/10.1158/1055-9965.epi-07-2840.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

11

Moskalenko, M. I., S. N. Milanova, I. V. Ponomarenko, A. V. Polonikov, and M. I. Churnosov. "Study of associations of polymorphism of matrix metalloproteinases genes with the development of arterial hypertension in men." Kardiologiia 59, no. 7S (August 23, 2019): 31–39. http://dx.doi.org/10.18087/cardio.2598.

Testo completo

Abstract (sommario):

The aim of research. To study the association of polymorphic loci of matrix metalloproteinases with the development of essential hypertension (EH) in men of the Central Chernozem Region of Russia. Materials and methods. A study of 564 men with EH and 257 control men was performed. Analysis of the polymorphic loci of metalloproteinases rs11568818 MMР7, rs1320632 MMР8, rs11225395 MMР8, rs1799750 MMР1, rs3025058 MMР3 was performed using real-time PCR. The study of associations of SNPs and their haplotypes with the development of arterial hypertension was carried out using logistic regression anal

Gli stili APA, Harvard, Vancouver, ISO e altri

12

Leite, Sergio Roberto de Andrade. "Inhibitors of human collagenase, MMP1." Eclética Química 34, no. 4 (December 2009): 87–102. http://dx.doi.org/10.1590/s0100-46702009000400008.

Testo completo

Abstract (sommario):

Different common drugs (Meloxicam, Tenoxicam and Piroxicam, and sodium alendronate) were tested both experimental and theoretically as inhibitors of interstitial human collagenase, also known as matrix metalloproteinase 1 (MMP-1). The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by the reaction with a fluorescent synthetic substrate and measuring the change of emission. Collagenase-inhibitor interaction was studied theoretically by computational calculations. Three among the four tested substances showed moderate inhibiting activity against the human c

Gli stili APA, Harvard, Vancouver, ISO e altri

13

Leite, Sergio Roberto De Andrade. "Inhibitors of human collagenase, MMP1." Eclética Química Journal 39, no. 4 (January 30, 2018): 87. http://dx.doi.org/10.26850/1678-4618eqj.v39.4.2009.p87-102.

Testo completo

Abstract (sommario):

Different common drugs (Meloxicam, Tenoxicam and Piroxicam, and sodium alendronate) were tested both experimental and theoretically as inhibitors of interstitial human collagenase, also known as matrix metalloproteinase 1 (MMP-1). The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by the reaction with a fluorescent synthetic substrate and measuring the change of emission. Collagenase-inhibitor interaction was studied theoretically by computational calculations. Three among the four tested substances showed moderate inhibiting activity against the human c

Gli stili APA, Harvard, Vancouver, ISO e altri

14

Calascibetta, A., V. Gebbia, D. Cabibi, A. Martorana, F. Aragona, L. Rausa, and R. Sanguedolce. "Matrix metalloproteinase-1 is differentially expressed in signet ring cell, and intestinal colorectal carcinomas histotypes." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 14564. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.14564.

Testo completo

Abstract (sommario):

14564 Background: Signet ring cell colorectal carcinoma ( SRCC) pure is an infrequent and highly malignant variant of colorectal cancer, while this histological component is present in 30% of all colorectal carcinomas. In our previous studies we compared the E- Cadherin, β- Catenin, Fibronectin, Ki 67 and Thymidylate Synthase (TS) expression of SRCC, the intestinal type of colorectal carcinoma (ICRC) to try to explain the pathogenesis, the aggressiveness and the low 5 Fluorouracil (5FU) responsiveness of these tumours. We found that all SRCCs had very low levels of all markers and were in the

Gli stili APA, Harvard, Vancouver, ISO e altri

15

Fanjul-Fernández, Miriam, Alicia R. Folgueras, Antonio Fueyo, Milagros Balbín, María F. Suárez, M. Soledad Fernández-García, Steven D. Shapiro, José M. P. Freije, and Carlos López-Otín. "Matrix Metalloproteinase Mmp-1a Is Dispensable for Normal Growth and Fertility in Mice and Promotes Lung Cancer Progression by Modulating Inflammatory Responses." Journal of Biological Chemistry 288, no. 20 (April 2, 2013): 14647–56. http://dx.doi.org/10.1074/jbc.m112.439893.

Testo completo

Abstract (sommario):

Human MMP-1 is a matrix metalloproteinase repeatedly associated with many pathological conditions, including cancer. Thus, MMP1 overexpression is a poor prognosis marker in a variety of advanced cancers, including colorectal, breast, and lung carcinomas. Moreover, MMP-1 plays a key role in the metastatic behavior of melanoma, breast, and prostate cancer cells. However, functional and mechanistic studies on the relevance of MMP-1 in cancer have been hampered by the absence of an in vivo model. In this work, we have generated mice deficient in Mmp1a, the murine ortholog of human MMP1. Mmp1a−/− m

Gli stili APA, Harvard, Vancouver, ISO e altri

16

Rosales, Alberto Sierra, Eduardo Alberto Villaseñor Rodríguez, Christian Lorena López González, Edy David Rubio Arellano, Susan Andrea Gutiérrez Rubio, and Teresa Arcelia García Cobián. "Association Between -1607 1G/2G Polymorphism of MMP1 and Temporomandibular Joint Anterior Disc Displacement with Reduction." Brazilian Dental Journal 31, no. 2 (April 2020): 152–56. http://dx.doi.org/10.1590/0103-6440202003037.

Testo completo

Abstract (sommario):

Abstract Anterior disc displacement with reduction (DDWR) is considered one of the most common disorders within the temporomandibular joint (TMJ), with a prevalence of 41% in adults. Matrix metalloproteinases play an important role in the degradation of the TMJ and the matrix metalloproteinase 1 (MMP1) 1607 1G/2G polymorphism increases the local expression of MMP1 thus leading to accelerated degradation of the extracellular matrix. The objective of this study was to evaluate the association between the 1607 1G/2G polymorphism of MMP1 gene and DDWR in a group of Mexican individuals from western

Gli stili APA, Harvard, Vancouver, ISO e altri

17

Srivastava, Priyanka, Ruchika Gangwar, Rakesh Kapoor, and Rama D. Mittal. "Bladder Cancer Risk Associated with Genotypic Polymorphism of the Matrix Metalloproteinase-1 and 7 in North Indian Population." Disease Markers 29, no. 1 (2010): 37–46. http://dx.doi.org/10.1155/2010/149651.

Testo completo

Abstract (sommario):

Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of bladder cancer (BC) and whether smoke exposure modifies this risk.Genotyping was performed in 200 BC patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).MMP1-1607 2G/2G andMMP7-181 GG genotype were associated with increased risk of BC (p<0.001; OR, 3.04; 95% CI1.71–5.39 and p, 0.005; OR, 2.38; 95% CI1.30–4.34) respectively. Smokers in

Gli stili APA, Harvard, Vancouver, ISO e altri

18

Wathes, D. Claire, Zhangrui Cheng, Mark A. Fenwick, Richard Fitzpatrick, and Joe Patton. "Influence of energy balance on the somatotrophic axis and matrix metalloproteinase expression in the endometrium of the postpartum dairy cow." REPRODUCTION 141, no. 2 (February 2011): 269–81. http://dx.doi.org/10.1530/rep-10-0177.

Testo completo

Abstract (sommario):

Postpartum dairy cows enter a period of negative energy balance (NEB) associated with low circulating IGF1, during which the uterus must undergo extensive repair following calving. This study investigated the effects of NEB on expression of IGF family members and related genes in the involuting uterus. Cows were allocated to two treatments using differential feeding and milking regimes to produce mild NEB or severe NEB (SNEB). Uterine endometrial samples collected 2 weeks post partum were analysed by quantitative PCR. The expression of IGF-binding protein 4 (IGFBP4) mRNA increased in the endom

Gli stili APA, Harvard, Vancouver, ISO e altri

19

Rohil, Vishwajeet, V. K. Vijayan, Raj Kumar, Rini Joshi, P. Pavani, Shweta Paul, Anju Sharma, and Mujeeb Ur Rahman. "A study on the correlation of matrix metalloproteinase MMP1 in COPD and smoking in the North Indian population." Asian Journal of Medical Sciences 8, no. 1 (January 3, 2017): 5–14. http://dx.doi.org/10.3126/ajms.v8i1.16020.

Testo completo

Abstract (sommario):

Background: Chronic Obstructive Pulmonary Disease (COPD) is characterized by airway obstruction and destruction of lung tissue, the disease for which at present there is no cure, although the treatment can slow worsening. Nearly 90% of COPD is caused by long term cigarette smoking; however, only 25% of chronic tobacco smokers develop COPD, the exact cause of this predisposition of some smokers to acquire COPD is still poorly understood at the molecular level. Lot of studies are available showing the correlation of MMP1 and asthma but not much work has been done on its correlation with COPD esp

Gli stili APA, Harvard, Vancouver, ISO e altri

20

Fu, Sai C., Barbara P. Chan, Wen Wang, Hon M. Pau, Kai M. Chan, and Christer G. Rolf. "Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis." Acta Orthopaedica Scandinavica 73, no. 6 (December 2002): 658–62. http://dx.doi.org/10.3109/17453670209178031.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

21

Fu, Sai C., Barbara P. Chan, Wen Wang, Hon M. Pau, Kai M. Chan, and Christer G. Rolf. "Increased expression of matrix metalloproteinase 1 (MMP1) in 11 patients with patellar tendinosis." Acta Orthopaedica Scandinavica 73, no. 6 (December 1, 2002): 658–62. http://dx.doi.org/10.1080/000164702321039624.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

22

Wang, Yu, Danyang Zhao, Xiao Wei, Lin Ma, Jing Sheng, and Ping Lu. "PEGylated Polyethylenimine Derivative-Mediated Local Delivery of the shSmad3 Inhibits Intimal Thickening after Vascular Injury." BioMed Research International 2019 (July 29, 2019): 1–15. http://dx.doi.org/10.1155/2019/8483765.

Testo completo

Abstract (sommario):

Intimal hyperplasia is a complex process which contributes to several clinical problems such as atherosclerosis and postangioplasty restenosis. Inhibition of Smad3 expression inhibits intimal thickening. Our previous study has modified biscarbamate cross-linked polyethylenimine derivative (PEI-Et) through PEGylation thus obtained polyethylene glycol-graft-polyethylenimine derivative (PEG-Et 1:1), which has lower cytotoxicity and higher gene transfection efficiency compared with PEI-Et. In this study, PEG-Et 1:1 was employed in Smad3 shRNA (shSmad3) delivery for preventing intimal hyperplasia a

Gli stili APA, Harvard, Vancouver, ISO e altri

23

Hui, Wang, Gary J. Litherland, Martina S. Elias, Gareth I. Kitson, Tim E. Cawston, Andrew D. Rowan, and David A. Young. "Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases." Annals of the Rheumatic Diseases 71, no. 3 (November 9, 2011): 455–62. http://dx.doi.org/10.1136/annrheumdis-2011-200372.

Testo completo

Abstract (sommario):

ObjectivesTo investigate the effect of leptin on cartilage destruction.MethodsCollagen release was assessed in bovine cartilage explant cultures, while collagenolytic and gelatinolytic activities in culture supernatants were determined by bioassay and gelatin zymography. The expression of matrix metalloproteinases (MMP) was analysed by real-time RT–PCR. Signalling pathway activation was studied by immunoblotting. Leptin levels in cultured osteoarthritic joint infrapatellar fat pad or peri-enthesal deposit supernatants were measured by immunoassay.ResultsLeptin, either alone or in synergy with

Gli stili APA, Harvard, Vancouver, ISO e altri

24

Lelongt, Brigitte, Germain Trugnan, Gillian Murphy, and Pierre M. Ronco. "Matrix Metalloproteinases MMP2 and MMP9 Are Produced in Early Stages of Kidney Morphogenesis but Only MMP9 Is Required for Renal Organogenesis In Vitro." Journal of Cell Biology 136, no. 6 (March 24, 1997): 1363–73. http://dx.doi.org/10.1083/jcb.136.6.1363.

Testo completo

Abstract (sommario):

We analyzed matrix metalloproteinase (MMP) production by 11-d embryonic mouse kidneys and the effects of these enzymes on subsequent renal organogenesis. In vivo, immunolocalization of metalloproteinases by laser scanning confocal microscopy and zymograms of kidney lysates showed that the mesenchyme of embryonic kidneys synthesized both MMP9 and MMP2 enzymes. In vitro, embryonic kidneys also secreted both enzymes when cultured in a medium devoid of hormone, growth factor, and serum for 24 h during which T-shaped branching of the ureter bud appeared. We then evaluated the role of MMP2 and MMP9

Gli stili APA, Harvard, Vancouver, ISO e altri

25

Koscica, Karen, Cande Ananth, and Sandra Reznik. "The effect of a matrix metalloproteinase-1 (MMP1) inhibitor on inflammation-mediated preterm delivery." American Journal of Obstetrics and Gynecology 189, no. 6 (December 2003): S67. http://dx.doi.org/10.1016/j.ajog.2003.10.028.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

26

Yassen, Mohy Eldin Abdel Fattah Abdel Atty, Olfat Ali Ibrahim Hammam, and Hazem Kamel Abdel-Aziz Mohamed Sarhan. "Expression of Matrix Metalloproteinase 1( MMP1 ) in Hepatocellular Carcinoma ( HCC ) : Immunohistochemical and Biochemical Studies." Egyptian Journal of Hospital Medicine 51 (April 2013): 289–99. http://dx.doi.org/10.12816/0000845.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

27

Yassen, Mohy Eldin abdel Fattah abdel Atty, Olfat Ali Ibrahim Hammam, and Hazem Kamel Abdel-Aziz Mohamed Sarhan. "Expression of Matrix Metalloproteinase 1(MMP1) in HepatoCellular Carcinoma (HCC): Immunohistochemical and Biochemical Studies." Egyptian Journal of Hospital Medicine 51, no. 1 (April 1, 2013): 289–99. http://dx.doi.org/10.21608/ejhm.2013.15979.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

28

Patra, Swagata, Parameswaran Saravanan, Bhaskar Das, Venkatesan Subramanian, and Sanjukta Patra. "Scaffold-based Screening and Molecular Dynamics Simulation Study to Identify Two Structurally Related Phenolic Compounds as Potent MMP1 Inhibitors." Combinatorial Chemistry & High Throughput Screening 23, no. 8 (November 2, 2020): 757–74. http://dx.doi.org/10.2174/1386207323666200428114216.

Testo completo

Abstract (sommario):

Background: Matrix metalloproteinase 1 are zinc-dependent endopeptidases responsible for the controlled breakdown of the extracellular matrix resulting in the maintenance of homeostasis. Dysregulation of MMP1 leads to the progression of various pathological conditions like cancer, rheumatoid arthritis, cardiovascular disease, skin damage and fibrotic disorder. Thus, MMP1 inhibition is the potential drug target of many synthetic MMP1 inhibitors but lack of substrate specificity hinders their clinical applicability. Hence, inhibitors from natural products have gained widespread attention. Object

Gli stili APA, Harvard, Vancouver, ISO e altri

29

Inzitari, Domenico, Betti Giusti, Patrizia Nencini, Anna Maria Gori, Mascia Nesi, Vanessa Palumbo, Benedetta Piccardi, et al. "MMP9 Variation After Thrombolysis Is Associated With Hemorrhagic Transformation of Lesion and Death." Stroke 44, no. 10 (October 2013): 2901–3. http://dx.doi.org/10.1161/strokeaha.113.002274.

Testo completo

Abstract (sommario):

Background and Purpose— Experimentally, matrix metalloproteinases (MMPs) play a detrimental role related to hemorrhagic transformation and severity of an ischemic brain lesion. Tissue-type plasminogen activator (tPA) enhances such effects. This study aimed to expand clinical evidence in this connection. Methods— We measured MMPs 1, 2, 3, 7, 8, 9, and tissue inhibitors of metalloproteinases 1, 2, 4 circulating level in blood taken before and 24 hours after tPA from 327 patients (mean age, 68.9±12.1 years; median National Institutes of Health Stroke Scale, 11) with acute ischemic stroke. Delta m

Gli stili APA, Harvard, Vancouver, ISO e altri

30

Li, Chuan, Zhi Peng, You Zhou, Yongyue Su, Pengfei Bu, Xuhan Meng, Bo Li, and Yongqing Xu. "Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip." Bone & Joint Research 10, no. 9 (September 1, 2021): 558–70. http://dx.doi.org/10.1302/2046-3758.109.bjr-2020-0421.r2.

Testo completo

Abstract (sommario):

Aims Developmental dysplasia of the hip (DDH) is a complex musculoskeletal disease that occurs mostly in children. This study aimed to investigate the molecular changes in the hip joint capsule of patients with DDH. Methods High-throughput sequencing was used to identify genes that were differentially expressed in hip joint capsules between healthy controls and DDH patients. Biological assays including cell cycle, viability, apoptosis, immunofluorescence, reverse transcription polymerase chain reaction (RT-PCR), and western blotting were performed to determine the roles of the differentially e

Gli stili APA, Harvard, Vancouver, ISO e altri

31

Supp, Dorothy M., Kevin L. McFarland, Jennifer M. Hahn, and Kelly A. Combs. "140 Alpha-Mangostin Inhibits Proliferation, Promotes Apoptosis, and Modulates Fibrotic Gene Expression in Normal and Keloid Fibroblasts In Vitro." Journal of Burn Care & Research 42, Supplement_1 (April 1, 2021): S93—S94. http://dx.doi.org/10.1093/jbcr/irab032.144.

Testo completo

Abstract (sommario):

Abstract Introduction Keloids are disfiguring lesions that result from an abnormal wound healing process. Despite the availability of numerous therapeutic options, keloids remain challenging to treat and often recur after therapy. α-Mangostin, a natural xanthone isolated from the fruit of the Mangosteen tree, has been used for centuries in many Southeast Asian nations for medicinal purposes, and has gained attention more recently due to its anti-inflammatory, antimicrobial, and antioxidant properties, with numerous studies suggesting possible anticarcinogenic activities. Hypothetically, α-mang

Gli stili APA, Harvard, Vancouver, ISO e altri

32

Olmos-Zuñiga, J. Raúl, Matilde Baltazares-Lipp, Claudia Hernández-Jiménez, Rogelio Jasso-Victoria, Miguel Gaxiola-Gaxiola, Mariana Silva-Martínez, Marco Antonio Iñiguez-García, et al. "Treatment with Hyaluronic Acid and Collagen-Polyvinylpyrrolidone Improves Extracellular Matrix Assembly for Scarring after Tracheal Resection." BioMed Research International 2020 (August 27, 2020): 1–15. http://dx.doi.org/10.1155/2020/3964518.

Testo completo

Abstract (sommario):

Treatment of tracheal stenosis is occasionally performed in combination with wound healing modulators to manipulate new extracellular matrix (ECM) formation and prevent fibrosis. Hyaluronic acid (HA) and collagen-polyvinylpyrrolidone (collagen-PVP) decrease fibrosis in experimental tracheal healing. However, they have not been used clinically as their effect on ECM components, which modify tracheal scarring, has not been described. Objective. To evaluate the effect of the application of HA, collagen-PVP, a mixture of HA and collagen-PVP (HA+collagen-PVP), and mitomycin C on the expression of d

Gli stili APA, Harvard, Vancouver, ISO e altri

33

Lefebvre-Lavoie, Josiane, Jacques G. Lussier, and Christine L. Theoret. "Profiling of differentially expressed genes in wound margin biopsies of horses using suppression subtractive hybridization." Physiological Genomics 22, no. 2 (July 14, 2005): 157–70. http://dx.doi.org/10.1152/physiolgenomics.00018.2005.

Testo completo

Abstract (sommario):

Disturbed gene expression may disrupt the normal process of repair and lead to pathological situations resulting in excessive scarring. To prevent and treat impaired healing, it is necessary to first define baseline gene expression during normal repair. The objective of this study was to compare gene expression in normal intact skin (IS) and wound margin (WM) biopsies using suppression subtractive hybridization (SSH) to identify genes differentially expressed during wound repair in horses. Tissue samples included both normal IS and biopsies from 7-day-old wounds. IS cDNAs were subtracted from

Gli stili APA, Harvard, Vancouver, ISO e altri

34

Chen, Jen-Liang, Chung-Yu Lai, Tsung-Ho Ying, Chiao-Wen Lin, Pei-Han Wang, Fang-Jung Yu, Chung-Jung Liu, and Yi-Hsien Hsieh. "Modulating the ERK1/2–MMP1 Axis through Corosolic Acid Inhibits Metastasis of Human Oral Squamous Cell Carcinoma Cells." International Journal of Molecular Sciences 22, no. 16 (August 11, 2021): 8641. http://dx.doi.org/10.3390/ijms22168641.

Testo completo

Abstract (sommario):

Corosolic acid (CA; 2α-hydroxyursolic acid) is a natural pentacyclic triterpenoid with antioxidant, antitumour and antimetastatic activities against various tumour cells during tumourigenesis. However, CA’s antitumour effect and functional roles on human oral squamous cell carcinoma (OSCC) cells are utterly unknown. In this study, our results demonstrated that CA significantly exerted an inhibitory effect on matrix metalloproteinase (MMP)1 expression, cell migration and invasion without influencing cell growth or the cell cycle of human OSCC cells. The critical role of MMP1 was confirmed using

Gli stili APA, Harvard, Vancouver, ISO e altri

35

Lee, Jaemin, Dong-Hee Kim, Eun-Woo Kim, Hyun Ju Kwon, Byung Woo Kim, Jae-Hyon Cho, Hyun-Joo Kim, and Tae Hoon Kim. "Matrix metalloproteinase-1 suppression and type-1 procollagen synthesis promoting effects of Uncaria gambir." Korean Journal of Food Preservation 24, no. 1 (February 2017): 93–99. http://dx.doi.org/10.11002/kjfp.2017.24.1.93.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

36

Cheng, Xiaoyun, Wenke Gao, Yongyan Dang, Xia Liu, Yujuan Li, Xu Peng, and Xiyun Ye. "Both ERK/MAPK and TGF-Beta/Smad Signaling Pathways Play a Role in the Kidney Fibrosis of Diabetic Mice Accelerated by Blood Glucose Fluctuation." Journal of Diabetes Research 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/463740.

Testo completo

Abstract (sommario):

Background. The notion that diabetic nephropathy is the leading cause of renal fibrosis prompted us to investigate the effects of blood glucose fluctuation (BGF) under high glucose condition on kidney in the mice.Methods. The diabetic and BGF animal models were established in this study. Immunohistochemistry, Western blot, and RT-PCR analysis were applied to detect the expression of type I collagen, matrix metalloproteinase-1 (MMP1), metalloproteinase inhibitor 1 (TIMP1), transforming growth factor beta 1 (TGF-β1), phosphorylated-ERK, p38, smad2/3, and Akt.Results. BGF treatment increased type

Gli stili APA, Harvard, Vancouver, ISO e altri

37

Li, Zhen, Hongzhou Ge, Yong-Gang Xie, Guang-Ying Xie, and Chao Lv. "Matrix Metalloproteinase-1 (MMP1) Polymorphism is Associated with Lowered Risk of Nasopharyngeal Carcinoma in Asian Population." Cell Biochemistry and Biophysics 71, no. 2 (October 14, 2014): 999–1004. http://dx.doi.org/10.1007/s12013-014-0299-4.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

38

Lin, Jiayu, Chaowen Deng, Yanzhong Peng, Jie Zheng, Liya Wei, Yu Shi, Zhenghua Gong, and Guoxin Hu. "Dynamic Changes in MMP1 and TIMP1 in the Antifibrotic Process of Dahuang Zhechong Pill in Rats with Liver Fibrosis." Open Chemistry 17, no. 1 (June 1, 2019): 346–56. http://dx.doi.org/10.1515/chem-2019-0041.

Testo completo

Abstract (sommario):

AbstractOn the basis of carbon tetrachloride (CCl4)induced liver fibrosis in rats, this study aims to investigate the dynamic changes in matrix metalloproteinase 1 (MMP1) and the tissue inhibitor of metalloproteinase 1 (TIMP1) in the antifibrotic process of Dahuang Zhechong Pill (DHZCP). A total of 50 male Sprague Dawley rats, aged 8 weeks, were randomly divided into 3 groups: the control group, the model group (the group treated with CCl4), and the treatment group (the group treated with CCl4 and DHZCP). Rats were sacrificed at Weeks 4 and 8. Liver tissues were separated for RNA sequencing an

Gli stili APA, Harvard, Vancouver, ISO e altri

39

El-Sheikh Ali, Hossam, Kirsten E. Scoggin, Rebecca Ruby, Alan Loynachan, Yatta Boakari, Claudia Fernandes, Pouya Dini, et al. "Equine cervical remodeling during placentitis and the prepartum period: a transcriptomic approach." Reproduction 161, no. 6 (June 1, 2021): 603–21. http://dx.doi.org/10.1530/rep-21-0008.

Testo completo

Abstract (sommario):

Cervical remodeling is a critical component in both term and preterm labor in eutherian mammals. However, the molecular mechanisms underlying cervical remodeling remain poorly understood in the mare. The current study compared the transcriptome of the equine cervix (cervical mucosa (CM) and stroma (CS)) during placentitis (placentitis group, n = 5) and normal prepartum mares (prepartum group, n = 3) to normal pregnant mares (control group, n = 4). Transcriptome analysis identified differentially expressed genes (DEGs) during placentitis (5310 in CM and 907 in CS) and during the normal prepartu

Gli stili APA, Harvard, Vancouver, ISO e altri

40

Kim, Young Joo, and Hwa Jun Cha. "Inonotus obliquus Extracts Decreased Expression of MMP1 mRNA via JNK-AP-1 Axis." Cosmetics 7, no. 2 (May 18, 2020): 36. http://dx.doi.org/10.3390/cosmetics7020036.

Testo completo

Abstract (sommario):

Inonotus obliquus, which is parasitic on birch and other trees, is a fungus in the family Hymenochaetaceae. In this study, we investigated whether Inonotus obliquus extracts used in traditional medicine were decreased in the expression of matrix metalloproteinases-1 (MMP-1) in the normal human dermal fibroblasts. As shown in our results, extracts of Inonotus obliquus decreased MMP1 expression in oxidative stress-exposed normal human dermal fibroblasts. Additionally, Inonotus obliquus extracts decreased AP-1 transcriptional activity and phospho-JNK in oxidative stress-exposed normal human derma

Gli stili APA, Harvard, Vancouver, ISO e altri

41

Li, Ming, Akitake Mukasa, Maria del-Mar Inda, Jianhua Zhang, Lynda Chin, Webster Cavenee, and Frank Furnari. "Guanylate binding protein 1 is a novel effector of EGFR-driven invasion in glioblastoma." Journal of Experimental Medicine 208, no. 13 (December 12, 2011): 2657–73. http://dx.doi.org/10.1084/jem.20111102.

Testo completo

Abstract (sommario):

Although GBP1 (guanylate binding protein 1) was among the first interferon-inducible proteins identified, its function is still largely unknown. Epidermal growth factor receptor (EGFR) activation by amplification or mutation is one of the most frequent genetic lesions in a variety of human tumors. These include glioblastoma multiforme (GBM), which is characterized by independent but interrelated features of extensive invasion into normal brain parenchyma, rapid growth, necrosis, and angiogenesis. In this study, we show that EGFR activation promoted GBP1 expression in GBM cell lines through a s

Gli stili APA, Harvard, Vancouver, ISO e altri

42

Chellaiah, Meenakshi A., and Tao Ma. "Membrane Localization of Membrane Type 1 Matrix Metalloproteinase by CD44 Regulates the Activation of Pro-Matrix Metalloproteinase 9 in Osteoclasts." BioMed Research International 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/302392.

Testo completo

Abstract (sommario):

CD44, MT1-MMP, and MMP9 are implicated in the migration of osteoclast and bone resorption. This study was designed to determine the functional relationship between CD44 and MT1-MMP in the activation of pro-MMP9. We used osteoclasts isolated from wild-type and CD44-null mice. Results showed that MT1-MMP is present in multiple forms with a molecular mass ~63, 55, and 45 kDa in the membrane of wild-type osteoclasts. CD44-null osteoclasts demonstrated a 55 kDa active MT1-MMP form in the membrane and conditioned medium. It failed to activate pro-MMP9 because TIMP2 binds and inhibits this MT1-MMP (~

Gli stili APA, Harvard, Vancouver, ISO e altri

43

Chen, Guobing, Dandan Ge, Bizhen Zhu, Huixuan Shi, and Qilin Ma. "Upregulation of matrix metalloproteinase 9 (MMP9)/tissue inhibitor of metalloproteinase 1 (TIMP1) and MMP2/TIMP2 ratios may be involved in lipopolysaccharide-induced acute lung injury." Journal of International Medical Research 48, no. 4 (April 2020): 030006052091959. http://dx.doi.org/10.1177/0300060520919592.

Testo completo

Abstract (sommario):

Objective This study aimed to examine the changes and significance of matrix metalloproteinase 9 (MMP9), MMP2, tissue inhibitor of metalloproteinase 1 (TIMP1), and TIMP2 in rats with lipopolysaccharide (LPS)-induced acute lung injury (ALI). Methods Wistar rats were randomly divided into a control group (injected with saline) and an ALI group (injected with LPS), then subdivided into four time points (2, 6, 12, and 24 hours). Serum tumor necrosis factor alpha and interleukin-6 levels were detected by ELISA to investigate the inflammatory reaction after LPS injection. The degree of ALI was deter

Gli stili APA, Harvard, Vancouver, ISO e altri

44

Verma, Archana, Aneesh Shrivastava, and Rama D. Mittal. "Association of Matrix Metalloproteinase 1 and 3 (MMP1 and MMP3) gene polymorphisms with susceptibility to ESRD risk in North Indian population." Molecular Cytogenetics 7, Suppl 1 (2014): P30. http://dx.doi.org/10.1186/1755-8166-7-s1-p30.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

45

Sauter, W., A. Rosenberger, L. Beckmann, M. Timofeeva, K. Mittelstrass, T. Illig, J. Chang-Claude, H. E. Wichmann, H. Bickeböller, and A. Risch. "Case-control study of genetic susceptibility in early onset lung cancer: Investigation of Matrix Metalloproteinase-1 (MMP1)." European Journal of Cancer Supplements 6, no. 9 (July 2008): 205. http://dx.doi.org/10.1016/s1359-6349(08)71903-7.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

46

Wang, Lijie, and Beihua Kong. "Analysis of the Association of Matrix Metalloproteinase-1 Gene Promoter (rs1799750) Polymorphism and Risk of Ovarian Cancer." International Journal of Gynecologic Cancer 25, no. 6 (July 2015): 961–67. http://dx.doi.org/10.1097/igc.0000000000000463.

Testo completo

Abstract (sommario):

ObjectiveStudies investigating the association betweenmatrix metalloproteinase-1(MMP1) gene promoter 1607–base pair (bp) polymorphism and ovarian cancer risk have yielded conflicting results.MethodsWe therefore carried out a meta-analysis of 754 ovarian cancer cases and 1184 controls from 5 published case-control studies. The strength of the association betweenMMP11607-bp polymorphism and ovarian cancer susceptibility was calculated using pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs).ResultsThe results suggest that no statistically significant associations exist be

Gli stili APA, Harvard, Vancouver, ISO e altri

47

Gömöri, Kamilla, Tamara Szabados, Éva Kenyeres, Judit Pipis, Imre Földesi, Andrea Siska, György Dormán, Péter Ferdinandy, Anikó Görbe, and Péter Bencsik. "Cardioprotective Effect of Novel Matrix Metalloproteinase Inhibitors." International Journal of Molecular Sciences 21, no. 19 (September 23, 2020): 6990. http://dx.doi.org/10.3390/ijms21196990.

Testo completo

Abstract (sommario):

Background: We recently developed novel matrix metalloproteinase-2 (MMP-2) inhibitor small molecules for cardioprotection against ischemia/reperfusion injury and validated their efficacy in ischemia/reperfusion injury in cardiac myocytes. The aim of the present study was to test our lead compounds for cardioprotection in vivo in a rat model of acute myocardial infarction (AMI) in the presence or absence of hypercholesterolemia, one of the major comorbidities affecting cardioprotection. Methods: Normocholesterolemic adult male Wistar rats were subjected to 30 min of coronary occlusion followed

Gli stili APA, Harvard, Vancouver, ISO e altri

48

Yuan, Yuan, Hisao Naito, Kazuya Kitamori, Sayuki Hashimoto, Tomomi Asano, and Tamie Nakajima. "The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension." PLOS ONE 15, no. 12 (December 14, 2020): e0243846. http://dx.doi.org/10.1371/journal.pone.0243846.

Testo completo

Abstract (sommario):

Hypertension is an important risk factor for nonalcoholic steatohepatitis. We have previously demonstrated that hypertensive rats fed a high fat and cholesterol (HFC) diet incurred a more severe hepatic inflammatory response and fibrosis. Here we investigated the role of hypertension in NASH by comparing HFC-induced hepatic fibrogenesis between spontaneously hypertensive rats (SHRs) and their normotensive Wistar Kyoto counterpart. Compared to the counterpart, the HFC diet led to stronger aggregation of CD68-positive macrophages in SHRs. HFC feeding also resulted in significantly higher upregul

Gli stili APA, Harvard, Vancouver, ISO e altri

49

Costa, L., I. Alho, A. G. Oliveira, M. Bicho, R. Carvalho, A. Fernandes, S. Ali, K. Leitzel, L. Demers, and A. Lipton. "309 POSTER Serum matrix metalloproteinase 1 (MMP1) as a prognostic marker in bone metastases (BM) treated with bisphosphonates." European Journal of Cancer Supplements 5, no. 4 (September 2007): 59. http://dx.doi.org/10.1016/s1359-6349(07)70327-0.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

50

Kang, Wesuk, Dabin Choi, and Taesun Park. "Dietary Suberic Acid Protects Against UVB-Induced Skin Photoaging in Hairless Mice." Nutrients 11, no. 12 (December 4, 2019): 2948. http://dx.doi.org/10.3390/nu11122948.

Testo completo

Abstract (sommario):

Ultraviolet (UV) radiation is a major cause of skin photoaging, which is mainly characterized by dryness and wrinkle formation. In the current study, we investigated the anti-photoaging effects of dietary suberic acid, a naturally occurring photochemical, using UVB-irradiated hairless mice. Mice were exposed to UVB three times weekly and fed diets containing three different suberic acid concentrations (0.05%, 0.1% and 0.2%) for 10 weeks. It was found that suberic acid inhibited UVB-induced skin dryness, wrinkle formation, and epidermal thickness in hairless mice. In parallel with phenotypic ch

Gli stili APA, Harvard, Vancouver, ISO e altri

Offriamo sconti su tutti i piani premium per gli autori le cui opere sono incluse in raccolte letterarie tematiche. Contattaci per ottenere un codice promozionale unico!