Tesi: "Multiplan"

1

Capponi, Bernard Balacheff Nicolas Laborde Jean-Marie. "Calcul algébrique et programmation dans un tableur le cas de Multiplan /". S.l. : Université Grenoble 1, 2008. http://tel.archives-ouvertes.fr/tel-00338688.

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2

Capponi, Bernard. "Calcul algébrique et programmation dans un tableur : le cas de Multiplan". Phd thesis, Grenoble 1, 1990. http://tel.archives-ouvertes.fr/tel-00338688.

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L'apprentissage des tableurs par des utilisateurs débutants, élevés de la fin de la scolarité obligatoire ou adultes du secteur tertiaire, pose un certain nombre de problèmes lies aux concepts algébriques en jeu, en particulier dans les formules du tableur; notamment la notion de références relatives. L'objet de ce travail est d'étudier la contextualisation des connaissances algébriques de ces utilisateurs dans un tableur. Nous avons particulièrement étudié le cas de multiplan#t#m. Nous avons ainsi pu mettre en évidence certains des obstacles que présente l'apprentissage a l'utilisation de ce type de logiciels. Nous avons également étudié la mise en œuvre de processus itératifs dans un tel environnement et étudie les aspects spécifiques présents dans multiplan au niveau d'itérations déroulées (replication)

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3

PELTIER, MARCEL. "Apport de l'echocardiographie transoesophagienne multiplan dans l'etude des stenoses aortiques orificielles de l'adulte : a propos de 86 cas". Amiens, 1994. http://www.theses.fr/1994AMIEM030.

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4

MAES, DAMIEN. "Evaluation du retrecissement aortique orificiel de l'adulte par la surface aortique planimetree en echographie transoesophagienne multiplan : a propos de 59 patients". Reims, 1994. http://www.theses.fr/1994REIMM065.

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5

Svensson, Jonas, Karl-Linus Blomberg e Joakim Eriksson. "Mapping of relations and dependencies using DSM/DMM-analysis : Casting mold manufacturing at Husqvarna". Thesis, Jönköping University, JIBS, Business Administration, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-256.

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Husqvarna is a Swedish company producing products for forestry, park and gardens. Due to harder competition they wish to increase efficacy in production. This can be achieved by shorter lead-times in the complex process of making casting molds. Activities within this process have certain relations and dependencies between each other that can be analyzed by using a Dependence Structure Matrix. The Dependence Structure Matrix is a tool that can improve efficiency by rearranging activities according to how they are dependent of each other.

The purpose is to make a Dependence Structure Matrix of activities that Husqvarna can use to analyze dependencies within the process of cast molding. The DSM Matrix will propose restructured activities of the process which can be evaluated to determine if greater efficacy can be reached.

To determine the activities within the process of making cast molds a workshop at Husqvarna for the people involved was conducted. A matrix has been constructed based on the information of activities and their dependencies. This information has then been analyzed by the software Multiplan.

The process of making casting molds could be analyzed by the DSM/DMM approach. A new order of how to carry out activities is the outcome of the analysis. The result can be analyzed by Husqvarna in order to determine if greater efficacy can be reached.

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6

Domingos, Vanda Beatriz Teixeira Coelho. ""Avaliação da hiperplasia do processo coronóide por meio da tomografia computadorizada helicoidal"". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-22032006-085436/.

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A hiperplasia do processo coronóide é uma afecção que causa uma limitada mobilidade mandibular e conseqüente limitação de abertura da boca. Não apresenta sintomatologia dolorosa, e tem progressão lenta, levando o paciente a procurar por tratamento somente se a limitação de abertura for severa a ponto de prejudicar as funções mastigatórias normais. Muitos casos levam clínicos a tratarem o paciente como portador de disfunção da articulação têmporo mandibular (DTM). Este trabalho se propõe a avaliar a tomografia computadorizada (TC) como método para auxiliar na elaboração do diagnóstico e no planejamento cirúrgico desta anomalia, estudando a presença da hiperplasia do processo coronóide pela observação de imagens obtidas por meio da Tomografia Computadorizada Helicoidal, considerando as imagens volumétricas multiplanar e 3D, e as suas associações. Foram utilizadas imagens de arquivo dos exames de tomografia computadorizada helicoidal de 152 pacientes que apresentavam sinais e sintomas de Disfunção Têmporo Mandibular (DTM) encaminhados para a Unidade de Diagnóstico Dento-Maxilo-Facial da Clínica Félix Boada, na cidade de Caracas - Venezuela, para exame tomográfico da ATM. Dos 152 pacientes, foram selecionados 20 casos, que eram de portadores de sinais e/ou sintomas de Disfunção Têmporo Mandibular, mas que, ao exame realizado, constatou-se a presença da hiperplasia do processo coronóide. Os dados dos 20 pacientes foram comparados, de maneira a identificar as possíveis diferenças entre as opiniões de 5 cirurgiões dentistas radiologistas e de 5 cirurgiões dentistas buco-maxilo-faciais. Utilizou-se a técnica da Análise de Médias (Analysis of Means - ANOM), que calcula uma média geral entre os 5 observadores de cada especialidade, e um intervalo que indica quais observadores tiveram opiniões semelhantes e quais tiveram opiniões diversas. Depois foi feita a comparação entre os dois grupos, utilizando o teste das proporções. Em conclusão, os observadores acharam as imagens MPR mais esclarecedoras que as reconstruções volumétricas 3D, na maioria dos casos de hiperplasia do processo coronóide, quando esses recursos foram avaliados separadamente. Contudo, acharam imprescindível a utilização de ambas as imagens, em associação ou não, indicando-as para o estudo da hiperplasia do processo coronóide. A hipomobilidade foi observada na articulação temporomandibular, no lado acometido pela hiperplasia do processo coronóide, em 55,2% dos casos
The Coronoid Process Hyperplasia is an affection that causes a limited mandibular mobility and a consequent limitation in mouth opening. It doesnt present any painful symptomatology and has a slow progression, leading the patient to look for treatment only when the opening limitation is severe to the point of impairing regular masticatory functions. Many cases lead clinicians to treat the patient as he had a temporomandibular dysfunction. This work proposed an evaluation of the CT as an auxiliary method in the elaboration of the diagnosis and in the surgical planning of that anomaly by studying the presence of the Coronoid Process Hyperplasia through the observation of images obtained by means of the Helicoidal Computerized Tomography, considering the volumetric multiplane and 3D images and their associations. Filed images of Helicoidal Computerized Tomography were used, belonging to the examination of 152 patients who presented symptoms of temporomandibular dysfunction and were all directed to the Dento-Maxillo-Facial Diagnosis Unit of the Clinica Felix Boada in the city of Caracas Venezuela for TMA tomographic examination. Of the 152 patients 20 were selected who showed signs or symptoms of TMA dysfunction and Coronoid Process Hyperplasia was detected. Data of the 20 patients were compared in order to identify possible differences among the opinions of 5 radiologist specialists and 5 buco-maxillo -facial specialists. The Analysis of Means ANOM was used to calculate a general average among the 5 specialists in each specialty and a gap that opinions and which ones had different opinions. Afterwards the comparison between the 2 groups was made using the Proportion Test. The observers concluded that the MPR images were more clarifying than the 3D images in most of the cases of coronoid process hyperplasia, especially when those resources were evaluated separately. Although they found vital the utilization of both images in association or not and indicated them to the study of the Coronoid Process Hyperplasia. Hypo mobility was observed in the TMA in the affected side in 55,2% of the cases

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7

Rozanski, Marta. "Bendamustin in Kombination mit Thalidomid und Prednisolon (BPT) bei Patienten mit rezidiviertem oder refraktärem Multiplem Myelom: Ergebnisse einer Phase-I-Studie". Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-97058.

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Thalidomid ist eine in der Therapie des fortgeschrittenen refraktären oder rezidivierten multiplen Myeloms (MM) wirksame Substanz, obwohl dosislimitierende Toxizitäten (DLT) ihren Einsatz beschränken können. In der vorliegenden Phase-I-Studie mit 28 Patienten mit rezidiviertem oder refraktärem MM nach konventioneller Chemotherapie oder Hochdosis (HD)-Chemotherapie mit Stammzelltransplantation (SCT) konnte gezeigt werden, dass eine Kombination von niedrig dosiertem Thalidomid mit Bendamustin und Prednisolon (BPT) die Wirksamkeit beibehält oder erhöht und gleichzeitig keine DLT auftritt. Die BPT-Therapie umfasste eine Dosis von Bendamustin (60mg/m2) Tag 1, 8 und 15 und Prednisolon (100mg) Tag 1, 8, 15 und 22, und eine eskalierende tägliche Dosis Thalidomid (50, 100, 200mg). Die Behandlungszyklen wurden alle 28 Tage bis zum Auftreten des maximalen Ansprechens, DLT oder Fortschreiten der Erkrankung wiederholt. 24 Patienten sprachen nach mindestens zwei Zyklen auf die Therapie an (vier komplette, sechs sehr gute partielle und 14 partielle Remissionen). Das mediane progressionsfreie Überleben und Gesamtüberleben für alle Patienten betrug 11 und 19 Monate. Nur leichte oder mittelschwere nicht-hämatologische Nebenwirkungen wurden beobachtet und kein Patient entwickelte dosislimitierende Hämatotoxizitäten. Die BPT-Therapie weist bei Patienten mit rezidiviertem oder refraktärem MM eine gute Verträglichkeit mit einem Ansprechen von über 80% auf. Die maximal tolerierte Dosis von Thalidomid wurde in dieser Studie nicht erreicht.

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8

Oladeinde, Abiola Omobolaji. "Linear demultiple solution based on bottom-multiple generator (BMG) approximation: subsalt example". Texas A&M University, 2005. http://hdl.handle.net/1969.1/4407.

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Significant quantities of hydrocarbons are found in complex salt environments. One of the modern challenges of exploration and production activities is to image below salt. This challenge arises from the complexities of salt structures, weak primaries from the subsalt, and the interference of free-surface multiples with the weak primaries of the subsalt. To effectively process subsalt data, we need to develop a method of attenuating free-surface multiples that preserves the amplitude and phase of primaries and does not introduce artifacts at either near and far offsets. In this thesis, we will demonstrate that the weak primaries of the subsalt can be preserved while attenuating free-surface multiples. The method used for the demonstration is the bottom-multiple generator (BMG) reflector approximation. This technique requires that a portion of the data containing only primaries be defined. A multidimensional convolution of the data containing only primaries with the actual data will predict free-surface multiples and hence is used to attenuate free-surface multiples from the actual data. This method is one of the most effective methods for attenuating free-surface multiples; however, the method requires muting data at the BMG location. One of the issues investigated in this thesis, is to establish the sensitivity of the BMG demultiple technique when the mute at the BMG location end up cutting some seismic reflections, which can be the case in complex environments such as the Gulf of Mexico and Gulf of Guinea, where freesurface multiples interfere with primaries. For this investigation, we generated synthetic data through the 2D elastic finite-difference modeling technique. The synthetic seismic data contain primaries; free-surface multiples, and internal multiples, and direct waves acquired over a 2D geological model that depicts a shallow-water geology. In this thesis, we also investigate if the first step of the BMG demultiple technique can sufficiently attenuate free-surface multiples. For this investigation, we designed a 2D geological model, which depicts the deep offshore environment, and we generated synthetic data through the 2D elastic finite-difference modeling technique. After performing the various investigations mentioned above, the following conclusions were made, that the demultiple result is not affected when the mute at the BMG location end up cutting some primaries, that the first step of the BMG demultiple technique is not sufficient for the demultiple, and that the weak subsalt primaries are preserved during demultiple processes. We compared shot gathers and zero offset data before and after the demultiple.

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9

PROU, EMMANUEL. "Les myelomes multiples atypiques : a propos d'une observation de myelome multiple non secretant". Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX2OO19.

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10

Kratz, Caroline Dorothea. "Multiple AV-nodale Leitungsbahnen mit multiplen Peaks im RR-Intervallhistogramm des Langzeit-Elektrokardiogramms bei chronischem Vorhofflimmern". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=965253929.

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11

Yngström, Sofia. "ADHD och musik : Jobbar skolan med musik som inlärningmetod för barn med ADHD?" Thesis, Karlstads universitet, Estetisk-filosofiska fakulteten, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-15454.

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A pupil with ADHD is constantly getting new impulses and is unable to focus and remain concentration on their task at school. When the pupil loses concentration he or she can often be loud and thereby disturbing all the other pupils in the classroom. One of the reasons for losing their concentration is that these pupils got poor working memory. A recently study shows that working memory can be improved by playing and practice music. A theory that all people have a multiple intelligence that emerges from learning is a part of this study because school should encourage all children and ensure their individual learning. Multiple intelligences means that each person learns in different ways, for example through the musical intelligence that this essay partly focuses on. Pupils with musical intelligence are absorbing information and learn through songs, rhythms and melodies. Then they associate their knowledge through this. In this essay, I interviewed two special education teachers and asked them how and if they use music in their special education with pupils that got ADHD. The result is that they are not using the music to a greater extent, but they would like to. Two music teachers were also interviewed to get a picture of what teachers with interest in music would like to do in school to make use of the music for the pupils that struggles.
ADHD är en diagnos som gör att eleven och till viss del alla omkring eleven får det jobbigt. En elev med ADHD får ständigt nya impulser och har svårt att rikta sin koncentration till samma ställe. Detta gör att det blir svårt för eleven att ta in instruktioner om en skoluppgift samt att bibehålla fokus och koncentration på uppgiften. När eleven tappar koncentrationen kan hon eller han ofta bli högljudd och därmed störa alla andra elever i klassrummet. Att eleverna tappar koncentrationen beror till viss del på svagt arbetsminne, vilket går att träna upp. En studie har visat att man genom musik, i detta fall instrumentalt genom övning, kan träna upp sitt arbetsminne. Teorier om att alla människor har en multipel intelligens som framträder vid inlärning är en del i denna uppsats då skolan ska främja alla barn och se till individen och dess lärande. Multipla intelligenser innebär att varje människa lär sig på olika sätt, exempelvis genom den musikaliska intelligensen som denna uppsats till viss del riktar in sig på. Genom musikalisk intelligens tar eleven till sig information och lär sig genom sånger, rytmer och melodier och associerar sedan sin kunskap genom detta. Till denna undersökning har jag intervjuat två specialpedagoger om hur och om de använder musiken i deras specialundervisning med elever med ADHD. Resultatet är dock att de inte använder musiken i större utsträckning, men att de vill veta mer. Två musiklärare intervjuades också för att få en bild om vad lärare med musikintresse tycker att man ska göra i skolan för att använda sig av musiken.

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12

Walker, Emily N. "The Emotional Needs of Mothers of Multiple Birth Children". Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc149682/.

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The purpose of this study was to assess the emotional support needs of mothers of multiple birth children based on administration of a survey the researcher developed. The survey consisted of 25 demographic items, six 6-point Likert scale items, and three open-ended questions. Likert scale items were based on amount of perceived emotional support mothers received in their environments at the time of survey administration. Open-ended questions addressed negative and positive aspects of parenting multiples and emotional support needs. The sample consisted of 171 mothers of multiple birth children from 23 states in the United States. Participants ranged in age from 20-50 years old with 38% not reporting age. Participants were 95.3% Caucasian, 0% African-American, 1.8% Asian, 0% Native American and 1.2% other; of these, 5.8% were Hispanic. We used demographic statistics and constant comparison to determine basic demographic characteristics of this sample and to identify emotional support needs of mothers of multiple birth children. We used Pearson product moment correlation to determine potential relationships between variables. Results indicated a statistically significant positive correlation between overall life satisfaction and partner satisfaction (r = .420, n = 170, p < 0.01). Therefore, mothers of multiples experience increased satisfaction with their lives when they receive greater support from partners. Also, results indicated a statistically significant positive correlation between partner satisfaction and partner caretaking responsibilities (r = .305, n = 169, p < 0.01). As partners of mothers of multiples increase contribution to caretaking of children, mothers demonstrate greater relationship fulfillment. Implications for mental health professionals working with mothers of multiple birth children are discussed.

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13

Li, Longguang. "On the capacity of free-space optical intensity channels". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLT028/document.

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Les systèmes de communication à intensité optique en espace libre (FSOI) sont largement utilisés dans les communications à courte portée, telles que les communications infrarouges entre des dispositifs électroniques portables. L’émetteur de ces systèmes module sur l’intensité des signaux optiques émis par des diodes électroluminescentes (LEDs) ou des diodes laser (LDs), et le récepteur mesure les intensités optiques entrantes au moyen de photodétecteurs. Les entrées ne sont pas négatives car elles représentent des intensités. En outre, ils sont généralement soumis à des contraintes de puissance de pointe et moyenne, la contrainte de puissance de pointe étant principalement dû aux limitations techniques des composants utilisés, alors que la contrainte de puissance moyenne est imposée par des limitations de batterie et des considérations de sécurité. En première approximation, le bruit dans de tels systèmes peut être supposé être gaussien et indépendant du signal transmis. Cette thèse porte sur les limites fondamentales des systèmes de communication FSOI, plus précisément sur leur capacité. L’objectif principal de notre travail est d’étudier la capacité d’un canal FSOI général à entrées multiples et sorties multiples (MIMO) avec une contrainte de puissance de crête par entrée et une contrainte de puissance moyenne totale sur toutes les antennes d’entrée. Nous présentons plusieurs résultats de capacité sur le scénario quand il y a plus d’antennes d’émission que d’antennes de réception, c’est à-dire, nT > nR > 1. Dans ce scénario, différents vecteurs d’entrée peuvent donner des distributions identiques à la sortie, lorsqu’ils aboutissent au même vecteur d’image multiplié par la matrice de canal. Nous déterminons d’abord les vecteurs d’entrée d’énergie minimale permettant d’atteindre chacun de ces vecteurs d’image. Il définit à chaque instant dans le temps un sous-ensemble de nT − nR antennes à zéro ou à pleine puissance et utilise uniquement les nR antennes restantes pour la signalisation. Sur cette base, nous obtenons une expression de capacité équivalente en termes de vecteur d’image, ce qui permet de décomposer le canal d’origine en un ensemble de canaux presque parallèles. Chacun des canaux parallèles est un canal MIMO nR x nR à contrainte d’amplitude, avec une contrainte de puissance linéaire, pour laquelle des limites de capacité sont connues. Avec cette décomposition, nous établissons de nouvelles limites supérieures en utilisant une technique de limite supérieure basée sur la dualité, et des limites inférieures en utilisant l’inégalité de puissance d’entropie (EPI). Les limites supérieure et inférieure dérivées correspondent lorsque le rapport signal sur bruit (SNR) tend vers l’infini, établissant la capacité asymptotique à haut SNR. À faible SNR, il est connu que la pente de capacité est déterminée par la trace maximale de la matrice de covariance du vecteur image. Nous avons trouvé une caractérisation de cette trace maximale qui est plus facile à évaluer en calcul que les formes précédentes
Free-space optical intensity (FSOI) communication systems are widely used in short-range communication such as the infrared communication between electronic handheld devices. The transmitter in these systems modulates on the intensity of optical signals emitted by light emitting diodes (LEDs) or laser diodes (LDs), and the receiver measures incoming optical intensities by means of photodetectors. Inputs are nonnegative because they represent intensities. Moreover, they are typically subject to both peak- and average-power constraints, where the peak-power constraint is mainly due to technical limitations of the used components, whereas the average-power constraint is imposed by battery limitations and safety considerations. As a first approximation, the noise in such systems can be assumed to be Gaussian and independent of the transmitted signal. This thesis focuses on the fundamental limits of FSOI communication systems, more precisely on their capacity. The major aim of our work is to study the capacity of a general multiple-input multiple-output (MIMO) FSOI channel under a per-input-antenna peak-power constraint and a total average-power constraint over all input antennas. We present several capacity results on the scenario when there are more transmit than receive antennas, i.e., nT > nR > 1. In this scenario, different input vectors can yield identical distributions at the output, when they result in the same image vector under multiplication by the channel matrix. We first determine the minimum-energy input vectors that attain each of these image vectors. It sets at each instant in time a subset of nT − nR antennas to zero or to full power, and uses only the remaining nR antennas for signaling. Based on this, we derive an equivalent capacity expression in terms of the image vector, which helps to decompose the original channel into a set of almost parallel channels. Each of the parallel channels is an amplitude-constrained nR⇥nR MIMO channel, with a linear power constraint, for which bounds on the capacity are known. With this decomposition, we establish new upper bounds by using a duality-based upper-bounding technique, and lower bounds by using the Entropy Power Inequality (EPI). The derived upper and lower bounds match when the signal-to-noise ratio (SNR) tends to infinity, establishing the high-SNR asymptotic capacity. At low SNR, it is known that the capacity slope is determined by the maximum trace of of the covariance matrix of the image vector. We found a characterization to this maximum trace that is computationally easier to evaluate than previous forms

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14

Esfandiari, Nazanene-Hélène. "Cancer bronchique primitif survenant aprés un premier cancer traité : à propos de 165 cas". Bordeaux 2, 1995. http://www.theses.fr/1995BOR2M068.

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15

Bichat, Antoine. "Prise en compte de l’organisation hiérarchique des espèces pour la découverte de signatures métagénomiques multi-échelles. Incorparating phylogenetic information in microbiome differential abundance studies has no effect on detection power and FDR control". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASM016.

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Cette thèse porte sur l'inclusion d'informations hiérarchiques dans des procédures de détection d'abondance différentielle sur des données métagénomiques. Les différents taxons qui composent le microbiote sont généralement accompagnés d'un arbre, comme la taxonomie ou la phylogénie, qui traduit une proximité biologique entre eux. Il est alors naturel de vouloir tirer parti de cette information hiérarchique afin d'augmenter la puissance des tests de détection de taxons différentiellement abondants. Dans un premier temps, nous nous sommes intéressés aux performances des procédures hiérarchiques existantes et à l'impact du choix de l'arbre sur celles-ci. Dans un second temps, nous avons développé notre propre méthode hiérarchique de détection d'abondance différentielle. Celle-ci modélise les z-scores associés à chaque taxon comme la réalisation d'un processus d'Ornstein-Uhlenbeck sur arbre avec sauts dans la valeur optimale du processus puis effectue une régression de type lasso pour déterminer les positions et intensités optimales des sauts
This thesis deals with the use of hierarchical information in differential abundance analyses in metagenomics. Taxa that make up the microbiome are usually associated with a tree, like the taxonomy or the phylogeny, that reflects a biological link between them. It is therefore natural to exploit this hierarchical information to increase the statistical power of differential abundance techniques. We first investigated the efficiency of existing hierarchical differential abundance detection procedures and the impact of tree choice on those. We then developed our own hierarchical differentially abundance detection procedure. It models the taxaassociated z-scores as realization of an Ornstein- Uhlenbeck process on a tree with shifts on its optimal value then a lasso-like regression is used to identify optimal positions and intensities of the shifts

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16

Besterman, Andreas, e Mattias Larsson. "Aktieavkastningars relation till fundamental multiplar : En studie om fundamentala värdedrivare och prisanomalier på marknaden". Thesis, Linköpings universitet, Företagsekonomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130857.

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Bakgrund: Tidigare studier har påvisat möjligheter till riskjusterad överavkastning genom tillämpandet av multiplar i konstruerandet av portföljer med målsättning att fånga mean-reversal effekten. De genomförda studierna har dock inte beaktat teoretiskt bakomliggande fundamentala variabler. Följaktligen är det av intresse att undersöka i vilken utsträckning en portfölj, sammansatt med hjälp av regression på en multipel, kan härleda avvikelser från jämvikt i aktiepriser och därmed generera högre avkastning än berättigat av risknivån på en effektiv marknad. Syfte: Studien ämnar empiriskt undersöka om aktiers framtida avkastning kan relateras till det värde som härleds genom relationen mellan deras fundamentala multiplar och marknadens faktiska multiplar. Genomförande: Studien härleder med hjälp av regressioner på multiplar aktiers jämviktspris och tillämpar avvikelser från dessa vid konstruktion av portföljer. Slutsats: Resultaten visar att en strategi baserade på regressioner av EV/EBITDA-multipeln kan generera en högre avkastning än berättigat av den effektiva marknadshypotesen under perioden 2006-2016. Liknande resultat har påvisats för P/E-multipeln men dessa kan inte statistiskt säkerställas på 95 % signifikansnivå. När det gäller EV/S-multipeln har inga indikationer på riskjusterad överavkastning påvisats.
Background: Previous studies has presented evidence of abnormal stock returns when applying valuemultiple based strategies in assembling portfolios. The previous studies has not consideredthe fundamental theoretical values that determine the value multiple. As a consequence, it isof interest to examine the performance of portfolios assembled with respect to thesefundamental value drivers. With the use of regression analysis, it is of interest to find out ifportfolios can be constructed that outperform the market portfolio in a sense of risk adjustedreturns. Purpose: This study aims to empirically examine if future stock returns can be derived from therelationship between their fundamentally determined multiples and the market multiple. Implementation: With the help of regression analysis of value multiples this study derives their equilibriumprice of stocks and apply deviation from equilibrium in construction of portfolios. Conclusion: The results indicate that a strategy based on regressions of the EV/EBITDA multiple maygenerate superior risk adjusted portfolio returns than suggested by the efficient markethypothesis during the period between 2006-2016. Similar results was found using the P/Emultiple however these results could not be statistically confirmed. Using the EV/S multipleno risk adjusted abnormal returns could be proven.

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17

Nobilet, Jean-Michel. "Systèmes MIMO (" Multiple Input Multiple Output ") à porteuses multiples :Etude et optimisation de la combinaison de codes temps-espace et des techniques MC-CDMA (" Multi-carrier code division multiple access ")". Rennes, INSA, 2004. http://www.theses.fr/2004ISAR0006.

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Dans la recherche de modulations adaptées à la voie descendante des systèmes cellulaires 4G, les systèmes MC-CDMA s'affirment comme des solutions à fort potentiel. En parallèle, les systèmes MIMO constituent une nouvelle voie très prometteuse améliorant notablement l'efficacité spectrale des systèmes hertziens via la dimension spatiale. Cette thèse porte sur l'optimisation de systèmes MIMO/MCCDMA par l'étude des codes temps-espace en blocs ou en treillis. Après un état de l'art, nous proposons de nouveaux codes STBC orthogonaux, puis une représentation des STTC basée sur une notation polynômiale permettant la comparaison des codes existants. La combinaison STBC/MC-CDMA étudiée améliore sensiblement les performances d'un système MC-CDMA SISO avec un décodage peu complexe. Leur optimisation repose sur des techniques de détection mono-utilisateurs ou multi-utilisateurs. Leur performances sont évaluées sur des canaux théoriques ou réalistes. Enfin, la combinaison STTC/MC-CDMA est étudiée
In the context of the research of new modulation schemes for the downlink of the 4th Generation mobile radio systems, the MC-CDMA schemes are the most promising candidates. On the other hand, MIMO systems inherit space diversity to mitigate fading effects and improve dramatically the spectrum efficiency. This thesis deals with the optimisation of MIMO/MC-CDMA systems through the use of space-time block coding or trellis coding. We propose new orthogonal STBC and a new representation of STTC based on a polynomial notation. The studied STBC/MC-CDMA systems improve the performance of a MC-CDMA SISO system with a low complex decoding. Their optimisation is based on single-user and multiple-user detection schemes. Their performance are evaluated on theoretical and realistic channels. Finally, the STTC/MC-CDMA is studied

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Vörös, András. "The emergence of multiple status systems in adolescent communities : a multiplex network theory of group formation". Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:9590194f-84e9-4548-b1fe-cf2f64ffc329.

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How do informal groups emerge in adolescent communities? What distinguishes a group from just a set of students? Who will end up together in a group and who will be left out? Why are there more groups in some classrooms and fewer in others? What determines whether these groups overlap in their members or they are completely segregated, perhaps antagonistic? While a huge body of research in sociology and social psychology focuses on these questions, an integrated approach that is able to answer all of them is yet to be developed. Without realizing that these five issues are interrelated, we cannot hope to understand how groups influence individuals and how they shape our communities. This thesis proposes an integrative theory of informal group formation in communities. Based on the tradition of Social Network Analysis, it develops a framework in which interpersonal relations and reputations are formed through a process called informal status production. Groups emerge from this micro-process by the alignment of positive relations and agreement in peer-perceptions between actors. The main micro-mechanisms predicted by the theory are tested on a unique longitudinal network dataset from school classrooms. To this end, a new empirical procedure was developed, by which a few aggregated networks can be constructed from tens of relational items. This allows the analysis of rich network data with several relational dimensions. The empirical studies of multiplex network dynamics confirm that there are strong interdependencies between friendships and perceptions. Students who agree about their peers tend to become friends, but more so when they hold a minority opinion in the class. This contributes to group formation. Friends also influence each other's perceptions, but we manage to show that the presence of groups around them interferes with this process by moderating the influence of individual peers.

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19

Ramos, André Daniel Alves. "Equity research - EDP Renováveis, SA". Master's thesis, Instituto Superior de Economia e Gestão, 2016. http://hdl.handle.net/10400.5/12581.

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Mestrado em Finanças
A EDP Renováveis, S.A. (EDPR) é uma empresa portuguesa internacional que opera no campo das energias renováveis, com posições-chave num importante número de mercados globais. Beneficiando de uma sólida estratégia de crescimento e expansão, tem registado uma performance constante e uma evolução positiva nas receitas nos últimos anos, não obstante o actual contexto macroeconómico. A dissertação em mãos tem como objectivo avaliar as acções da EDPR e determinar o valor de avaliação da empresa. Para o efeito foi realizado um equity report com vista a apurar a performance da companhia como um todo, bem como ao sector de indústria em que está inserida, as suas perspectivas de crescimento e os factores que, directa e indirectamente, têm impacto no outcome operacional. Os principais drivers para o bom desempenho da empresa são o crescimento das vendas e o sucesso do Programa de Rotação de Activos. Os métodos de avaliação escolhidos foram o Adjusted Present Value (APV) e a Avaliação por Múltiplos. De acordo com a avaliação realizada o valor da empresa situa-se nos €16.169 milhões, correspondendo a um preço-alvo de €9.20, 27% abaixo do seu valor intrínseco de €7.25 à data de 31.12.2015. A avaliação por múltiplos fundamentou o resultado obtido pelo APV, estimando o preço-alvo da empresa acima do seu valor na data em análise. Por último foi efectuada a simulação de Monte Carlo, tendo corroborando os resultados obtidos previamente. Apresentamos portanto aos potenciais investidores uma recomendação de compra.
EDP Renováveis, S.A. (EDPR) is a multinational Portuguese company operating in the field of renewable energy, with key positions in a number of important global markets. Benefiting from a well-devised growth and expansion strategy, EDPR has had a consistent performance and sustainable growth in revenues in recent years, despite the current macroeconomic scenario. The goal of this study is to value EDPR stocks and determine the firm value. To this end, an equity report was developed. The company's performance was therefore evaluated, along with its growth perspectives and the factors which, directly and indirectly, have an impact on its operational outcome. The main drivers of the value are the company's growth in revenues and the implementation of its Asset Rotation Program. The valuation methods applied were the Adjusted Present Value (APV) method and the Relative Valuation (multiples) method. We estimate that the EDPR's firm value is €16.169 million, corresponding to a price target of €9.20, thus representing a 27% depreciation when compared to its trading price of €7.25 on the 31.12.2015. The Relative valuation computed also shows that EDPR's share price is undervalued when in comparison to the same date. Finally, a Monte Carlo simulation was performed to further complement the report. We therefore provide potential investors with a buy recommendation.

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20

Suárez, Real Alberto. "Resource allocation for multiuser uplink systems". Nice, 2010. http://www.theses.fr/2010NICE4077.

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Dans cette thèse nous étudierons l’allocation de puissance optimale pour des systèmes de communication multi utilisateur en lien ascendant. L’ordre de décodage et l’allocation de puissance optimaux pour minimiser la consommation totale de puissance sont déterminés lorsque les utilisateurs ont des contraintes de débit et que la suppression d’interférence est utilisée dans la station de base. De plus, nous chercherons à déterminer dans quelles conditions il est possible de faire une allocation distribuée en ne se basant que sur les connaissances statistiques du système. Par la suite nous considérerons les systèmes a entrées multiples sorties multiples, afin d’obtenir les matrices de précodage optimales pour que chaque utilisateur maximise son taux de transmission ergodique avec la seule connaissance des statistiques des canaux. Les bénéfices de l’utilisation d’un signal de coordination et de décodages successifs sont analysés. Ensuite, nous considérerons un scénario dans lequel les terminaux mobiles ont la possibilité de se connecter simultanément à plusieurs stations de base en utilisant des bandes de fréquence non superposées. L’allocation de puissance optimale est dérivée pour différents types de récepteurs et un algorithme itératif est proposé pour obtenir l’allocation optimale. Finalement, nous considérerons les contrôles d’accès au canal décentralisé entre utilisateurs choisis aléatoirement parmi une population nombreuse, avec de nombreuses interactions entre paires d’utilisateurs où les utilisateurs sont en concurrence pour une opportunité d’accès. Le choix du niveau de puissance est fait par chaque utilisateur, et nous analyserons à la fois les scénarios d’équipe et non coopératifs
In this thesis we study the subject of resource allocation for uplink communication systems. When users have target rate constraints and interference cancelation is used at the base station we provide the optimal decoding order and power allocation in order to minimize the power consumption. In addition conditions are derived under which the allocation can be done in a distributed way, with only some knowledge of the statistics of the system. We then proceed to consider multiple-input multiple-output (MIMO) systems, and obtain the optimal precoding matrices such that each user maximizes its own ergodic transmission rate from the sole knowledge of the overall channel statistics. The benefits of using a coordination signal and successive decoding are analyzed. Next, a scenario in which mobile terminals can be simultaneously connected to several base stations, using non-overlapping frequency bands is considered. The optimal power allocation in terms of sum rate is derived for different receiver types and an iterative algorithm proposed to achieve the optimal allocation. Finally, we consider decentralized medium-access control in which many pairwise interactions, where users compete for a medium access opportunity, occur between randomly selected users that belong to a large population. The choice of power level is done by each user, and both team and noncooperative scenarios are analyzed

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Saidi, Taofik. "Architectures matérielles pour la technologie W-CDMA étendue aux systèmes multi-antennes". Doctoral thesis, Université Laval, 2009. http://hdl.handle.net/20.500.11794/20828.

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Depuis une dizaine d 'années, l'avènement des techniques multi-antennes (ou MIMO) pour les communications sans fil , mobiles ou fixes , a révolutionné les possibilités offertes pour de nombreux domaines d 'application des télécommunications. La disposition de plusieurs antennes de part et d 'autre du lien augmente considérablement la capacité des systèmes sans fil. Cependant, les algorithmes numériques à mettre en oeuvre pour réaliser ces systèmes sont autrement complexes et constituent un challenge quant à la définition d'architectures matérielles performantes. L'objectif du travail présent repose précisément sur la définition optimale de solutions architecturales, dans un contexte CDMA, pour contrer cette problématique. Le premier aspect de ce travail porte sur une étude approfondie des algorithmes spatio-temporels et des méthodes de conception en vue d'une implantation matérielle efficace. De nombreux schémas de détection sont proposés dans la littérature et sont applicables suivant trois critères qui sont: la qualité de service, le débit binaire et la complexité algorithmique. Cette dernière constitue une contrainte forte pour une mise en application à faible coût de terminaux mobiles intégrant ces applications. Aussi, il est nécessaire de disposer d'outils performants pour simuler, évaluer et affiner (prototypage rapide) ces nouveaux systèmes, candidats probables pour les télécommunications de quatrième génération. Le second aspect concerne la réalisation d'un transcepteur multi-antennes sans codage de canal, intégrant la technologie d'accès multiple par répartition de codes dans le cas d'un canal large bande. Un système mono-antenne WCDMA, généralisable à un nombre quelconque d'antennes, a été intégré et simulé au sein de la plate-forme de prototypage rapide Lyrtech. L'architecture développée intègre les principaux modules du traitement en bande de base, à savoir le filtrage de Nyquist, la détection des multiples trajets suivie de l'étape de détection. Le prototype MIMO-WCDMA développé est caractérisé par sa flexibilité suivant le nombre de voies e~trantes, le format d'entrée des échantillons, les caractéristiques du canal sans fil et la technologie ciblée (ASIC, FPGA). Le troisième aspect se veut plus prospectif en détaillant de nouveaux mécanismes pour réduire le coût matériel des systèmes multi-antennes. Le principe d'allocation adaptative de la virgule fixe est présenté dans le but d'adapter le codage des données suivant les caractéristiques du canal sans fil et de minimiser en conséquence la complexité du circuit. D'autre part, le concept d'architectures adaptatives est proposé afin de minimiser l'énergie consommée au sein d 'un système embarqué suivant le contexte d'application.

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22

Wang, Yu. "Development of a multiplex fluorescent immunoassay for the simultaneous detection of serum antibodies to multiple swine pathogens". Thesis, Kansas State University, 2013. http://hdl.handle.net/2097/15704.

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Master of Science
Department of Diagnostic Medicine and Pathobiology
Raymond R. R. Rowland
Three economically important swine diseases: Porcine Reproductive and Respiratory Syndrome (PRRS), Porcine Circovirus Associated Disease (PCVAD) and Swine influenza cost the US swine industry more than a billion dollars each year. This study developed a fluorescent microsphere immunoassay (FMIA) to simultaneously detect antibodies to the causative pathogens: PRRSV, porcine circovirus (PCV2) and swine influenza virus (SIV). The results showed that the multiplex assay possessed the predicted specificities. In the case of PRRSV NA, the assay displayed higher sensitivity when compared to a commercially available ELISA. The assay was employed to measure both IgG and IgM responses. The FMIA was found to possess several advantages over standard ELISA which include reduced sample volume, time and cost and provides a new tool for veterinary diagnostics. The FMIA was applied for swine disease surveillance in Hawaiian and Texan feral swine populations. The antibodies against PCV2 showed the highest prevalence among these three pathogens in both Hawaii and Texas. Hence we consider PCV2 as the most prevalent pathogen in Hawaiian and Texan feral pigs and this pathogen poses the greatest threat to commercial pigs. SIV seroprevelance increased from 2007 to 2010 in Hawaii State, suggesting an increasing risk for commercial pigs. Moreover, yearly surveillance in Texas State shows growth in seropositive response to all pathogens, particularly PCV2. The development of FMIA for detection of antibodies to multiple swine pathogens in serum samples offers an important alternative for swine disease surveillance in commercial and feral herds.

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Alm, Sofia. "The Locked-In Identity? : A case study of the management of multiple organizational identities in a dependent partner organization". Thesis, KTH, Skolan för industriell teknik och management (ITM), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-279660.

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For decades´ researchers as well as business managers have deliberated on the matter of what constitutes an organization´s core and identity. This paper investigates the management of multiple identities in a dependent partner organization, defined as an organization with products or services dependent on, and/or with a business derived from, a mother organization´s products or services. For managers, managing organizational identity on organizations with an increasing part of their business value dependent on partnering with another organization, this becomes a question of managing multiple identities. As an aid for managers in determining the relevant managerial response, Pratt and Foreman developed a framework classifying four different responses, presented in an article in the year 2000. However, in limmiting the scope of their research to not include an organization´s perception of the identity of the external network in which it resides, the framework is not sufficient for managers of a dependent partner organization. The current research has analyzed and further developed how the managerial response framework for multiple identities could be used in such a dependent partner organizational setting. The perception of how a mother organization is reflected in a dependent partner organization identity is investigated through interviews ina single case study at a specigic type of dependent partner organization, namely a dealer organization. The analysis of the data was deductive, based on the theoretical construct of organizational identity, and followed a theoretical thematic analysis methodology. The findings from the research reveal how different perceptions of the mother organization is reflected in every criterion of the dependent partner´s organizational identities. Also, results show how these organizations are high in synegry, as the mother organization creates a standard frame of reference for all units of the dependent partner. The results further develop the managerial framework by Pratt and Foreman for such an organizational setting by syggesting two responses from the framework as particularly suitable. For managers of a dependent partner organization the risk of the high presence of the mother organization in the own organizational identity is also coupled with decreased member identification. To manage this, it is suggested to engage in internal employee education and activities. Furthermore, an increased focus on fostering a strong leadership, capable of consciously managing the constant construction of organizational identity in the blurred lines between the partner and the mother organization, is needed. Due to the positioning of organizational identity as a constructed in the interaction between two parts, social constructionism is further suggested to be an appropriate epistemological view when studying the dependent partner organization.
I årtionden har akademiker och chefer brottats med nfrågan om vad som är en organisations kärna och identitet. Denna uppsats undersöker hanteringen av multipla identiteter i en beroende partnerorganisation, här definierad som en organisation vars produkter eller tjänster är beroende av, och/eller sprunget från, en moderorganisations produkter eller tjänster. Hanteringen av en organisations identitet är en del av chefens huvudsakliga syfte och i organisationer där grundaffären alltmer beror av en partnerorganisation blir detta en fråga om att hantera multipla identiteter. Pratt och Foreman presenterade i en artikel år 2000 ett ramverk för chefer som klassificerar fyra olika responser i hanteringen av multipla identiteter. Studien är dock avgränsad till att inte innefatta organisationers uppfattning om identiteten av det externa nätverk inom vilken organisation är en del, i den egna organisatoriska identiteten. Denna avgränsning gör ramverket otillräckligt för chefers bedömning av hanteringen av multipla identiteter i beroende partnerorganisatoriska. Den nuvarande studien har analyserat och vidareutvecklat ramverket för hantering av multipla identiteter utifrån den beroende partnerorganisationens position. Hur moderorganisationen uppfattas och reflekteras i den beroende partnerorganisationens i dentitet har undersökts genom intervjuer i en enfallsstudie hos en specifik typ av beroende!partnerorganisation, nämligen en återförsäljare. Analysen av data har varit!deduktiv, baserad på teorin om vad!som utgör en organisatorisk identitet, och har följt en teoretisk tematisk analysmetod. Resultaten från studien visar hur uppfattningar om moderorganisationen reflekteras i varje kriterium av den beroende partnerorganisationens identitet och hur dessa typer av organisationer har möjlighet till höga synergieffekter, som en följd av att moderorganisationen skapar en gemensam gruns att stå på. Resultaten leder till en vidareutveckling av Pratt och Foremans ramverk för hanteringen av multipla identiteter genom att föreslå två av responserna som mer anpassade för den specifika organisationstypen. För chefer i en beroende partnerorganisation är risken med den starka närvaron av moderorganisationen i den egna identiteten att medlemsidentifieringen misnkar. För att hantera detta föreslås att bygga upp en intern utbildning samt uppmuntra interna aktiviteter. Det föreslås också att fokusera på att fostra ett starkt ledarskap som är kapabelt atill att medvetet hantera den konstanta konstruktionen av den egna organisatoriska identiteten i gråzonen mellan moderorganisationen och den beroende partnerorganisationen. Vidare är också scocialkonstruktionismen identifierad att vara en lämplig epistemologisk ståndpunkt vid studien av en beroende partnerorganisation, givet att den organisatoriska identiteten konstrueras i relation till en annan part.

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Sälzer, Thomas. "Transmission Strategies Employing Multiple Antennas for theDownlink of Multi-Carrier CDMA Systems". Rennes, INSA, 2004. http://www.theses.fr/2004ISAR0004.

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La transmission multiporteuse à accès multiple par répartition de codes (MC-CDMA) est un candidat prometteur pour les nouvelles interfaces radio des futurs systèmes radio-mobiles. Cette thèse explore le potentiel des techniques d'antennes multiples en voie descendante d'un système MC-CDMA. Le pré-filtrage spatio-fréquentiel est proposé pour le cas où l'émetteur dispose d'une connaissance instantanée du canal. Cette technique permet de bénéficier de manière optimale de la diversité spatiale du canal et de réduire efficacement l'interférence d'accès multiple. Si seule la covariance spatiale du canal est disponible, nous proposons la formation de voies avec répartition directionnelle des codes d'étalement. Cette technique profite du gain d'antennes et d'une réduction implicite de l'interférence d'accès multiple. Les deux approches augmentent la capacité en terme de nombre d'utilisateurs tout en permettant un transfert de la complexité algorithmique du terminal vers la station de base
Multi-Carrier CDMA (MC-CDMA) combining multi-carrier modulation and spreading in the frequency domain is a promising candidate for new air interfaces of future mobile radio systems. This thesis explores the potential of multiple antenna technologies for the downlink of an MC-CDMA system. Space-frequency transmit filtering is proposed for the case where instantaneous knowledge of the channel fading is available at the basestation. This approach can optimally exploit the spatial diversity of the channel and efficiently mitigate the multiple access interference. When only covariance knowledge is available, we propose transmit beamforming with direction-based spreading code assignment. This technique benefits from the antenna gain and from an implicit reduction of the interference. Both transmission strategies lead to an increased user capacity and simultaneously allow a transfer of implementation complexity from the mobile terminal to the basestation

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Valette, Victorien. "Prévalences et impact de Wolbachia sur la diversité génétique chez les isopodes terrestres, Armadillidium vulgare et Porcellionides pruinosus". Thesis, Poitiers, 2015. http://www.theses.fr/2015POIT2322/document.

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La diversité génétique est un élément majeur pour l'évolution des espèces dans un environnement changeant. Chez les isopodes Armadillidium vulgare et Porcellionides pruinosus, l'infection par Wolbachia engendre une féminisation des mâles pouvant entraîner des sex-ratios fortement biaisés en faveur des femelles. Cela réduit la taille efficace des populations infectées qui peut provoquer une réduction de la diversité génétique. Cependant, chez A. vulgare, il existe un maintien de cette diversité qui pourrait être dû à des prévalences trop faibles de Wolbachia pour impacter les populations ou à d’autres facteurs comme par exemple lors de la reproduction un choix préférentiels des mâles pour les femelles génétiques. Un suivi des prévalences de Wolbachia dans des populations naturelles d’A. vulgare a été réalisé sur plusieurs années à partir d’une nouvelle méthode basée sur le génotypage. Les résultats montrent (i) des infections multiples de Wolbachia et (ii) des prévalences faibles pour wVulM, wVulC et wVulP. La présence d'un second facteur féminisant appelé f est suspectée dans de nombreuses populations. A l’échelle individuelle, Wolbachia semble avoir un impact sur le nombre de multi-paternités puisque les femelles génétiques s’accouplent avec plus de mâles que les néo-femelles. Les faibles prévalences de Wolbachia et les accouplements multiples permettent de maintenir une diversité génétique importante au sein des populations d’A. vulgare. Chez P. pruinosus, les prévalences de Wolbachia sont élevées et on observe de forts taux de consanguinité. Cependant, ces taux pourraient également résulter de fluctuations d’effectifs dans ces populations liées à un habitat spécialisé et peu stable
Genetic diversity is a crucial component for the evolution of species in changing environments. In the isopods Armadillidium vulgare and Porcellionides pruinosus, infection with Wolbachia bacteria causes a feminization of males that could lead to strongly female-biased sex-ratios. This reduces the effective size of infected populations and may result in a decreased genetic diversity. Nevertheless, genetic diversity is known to be maintained in A. vulgare. This might be due to Wolbachia prevalences being too low to impact host populations, or to other factors, as for example males preferentially choosing genetic females for reproduction. Wolbachia prevalence has been monitored over several years in natural populations of A. vulgare using a new genotyping method. The results demonstrate (i) multiple Wolbachia infections and (ii) low prevalences of wVulM, wVulC and wVulP. The presence of a second feminizing factor, called f, is suspected in numerous populations. At the individual scale, Wolbachia seems to have an effect on the number of multiple paternities, since genetic females mate with more males than neo-females. Low Wolbachia prevalence and multiple mating may allow the maintenance of a high genetic diversity in A. vulgare populations. In P. pruinosus, Wolbachia prevalences are high and we observe high consanguinity rates. However, these rates might also result from fluctuations in population size due to a specialized and unstable habitat

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Hélard, Jean-François. "Modulations codées en treillis associées à un multiplex de porteuses orthogonales en présence de canaux affectés de trajets multiples". Rennes 1, 1992. http://www.theses.fr/1992REN1S117.

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Bouvet, Pierre-Jean. "Récepteurs itératifs pour systèmes multi-antennes". Rennes, INSA, 2005. http://www.theses.fr/2005ISAR0021.

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Akgün, Katja, Imke Metz, Hagen H. Kitzler, Wolfgang Brück e Tjalf Ziemssen. "Rescue therapy with alemtuzumab in B cell/antibody-mediated multiple sclerosis". Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35543.

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Alemtuzumab exerts its clinical efficacy by its specific pattern of depletion and repopulation of different immune cell subsets. Recently, single cases of multiple sclerosis patients who developed severe exacerbation after the first alemtuzumab application, accompanied by re-appearance of peripheral B cells, were reported. Here we present a case with underlying B cell-driven multiple sclerosis that impressively improves after alemtuzumab, although peripheral B cell repopulation took place. Our detailed clinical, histopathological, imaging and immunological data suggest that alemtuzumab can act as an effective rescue treatment in highly active B cell-driven and antibody/complement-mediated multiple sclerosis type II patients.

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Coralic, Sanela, e Sofia Siira. "En analys av lärarhandledningar inom biologiämnet och Lpo 94 : en fråga om begränsad undervisningsvariation?" Thesis, Södertörn University College, Lärarutbildningen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-2076.

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During our education time, we have heard on several occasions how the high changing rate in the society also influences the education area. That changing process mainly originates from the transform that a school underwent, i.e. the decentralization meaning a delegation of responsibility from a national to local government and the particular school. The main idea that started a changing process goes under the slogan “a school for everyone”. The new school was created by the newest teaching plan where the individualization of each individual student is a main point on the agenda. A countless number of analyses of Lpo 94 during our education have given us a reason to reflect over how this individualization should take place. The ambition to find an answer on that question led us to start from a couple of questions at issues that foremost handles children’s different ways to learn as well as the design of the teaching supervision in contrast to today’s teaching plan and the newer research within the chosen subject area. The aim of this work is thus to analyze and understand the contents of four different teaching supervisions within biology as a subject area and to try to appoint whether requirements on varied education from Lpo 94 is obeyed. Our answer on how to achieve requirements on individualization from Lpo 94, during this work, is to apply a varied education with a number of senses and intelligences as a frame of reference. Our conclusion and thus the result of our analysis is that the teaching supervisions deficiently reach the requirements that involve varied education in Lpo 94. The degree deficiency varies between different teaching supervisions.

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Oliveira, Isabel Maria Rodrigues do Amaral. "Characteristics of communicative interactions between children with multiple disabilities and their non-trained teachers: Effects of an intervention process". Doctoral thesis, Faculdade de Psicologia e Ciências da Educação, Universidade do Porto, 2002. http://hdl.handle.net/10400.12/1653.

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Tese de Doutoramento apresentada à Faculdade de Psicologia e Ciências da Educação, Universidade do Porto
Children with multiple disabilities often do not use speech to communicate. Communication with such learners requires the use of non-linguistic modes of communication that are not always mastered by teachers and other adults in school. This study intended to describe the communicative characteristics of interactions between two multiple disabled non-speaking children and their teachers. Characteristics of interaction of two teacher/ child dyads as well as an intervention process designed to respond to teachers' communicative needs are described through the use of qualitative and quantitative methods. Results indicate that teachers miss opportunities for communication with learners with multiple disabilities and that an intervention procedure that decreases the number of behaviors that are not responded to by teachers does not substantially change interactions. Issues emerged from data analyses that need to be attended to when interacting with learners who do not use speech to communicate. A discussion of such issues is included in the discussion of results. Results of data analysis support the development of suggestions for practice aimed at helping teachers with no training in special education plan their communication intervention with learners with multiple disabilities. ------ RESUMO ------- As crianças com multideficiência frequentemente não usam a fala como modo de comunicação. A comunicação com estas crianças requer a utilização de meios não linguísticos de comunicação que nem sempre são do conhecimento dos professores nem de outros adultos na escola. Este estudo tem como objectivo descrever as características da comunicação entre duas crianças com multideficiência e as educadoras que com elas trabalham. Através de metodologias qualitativas e quantitativas são descritas as características das interacções entre duas díades criança/educadora, bem como um processo de intervenção destinado a responder às necessidades comunicativas expressas peias educadoras. Os resultados indicam que as educadoras perdem oportunidades de comunicação e que uma intervenção centrada na redução do número de comportamentos não respondidos pela educadora não altera substancialmente as interacções. A análise de dados permitiu a identificação de aspectos que necessitam de ser tidos em consideração nas interacções com alunos com multideficiência que não usam a fala para comunicar. Estes aspectos são discutidos no capítulo de discussão de resultados. Os resultados da análise de dados servem de base ao desenvolvimento de sugestões para a prática destinadas a auxiliar professores/ educadores não especializados no planeamento da sua intervenção a nível da comunicação com crianças multideficientes.

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Saidi, Taofik Sentieys Olivier Roy Sébastien. "Architectures matérielles pour la technologie W-CDMA étendue aux systèmes multi-antennes". Rennes : [s.n.], 2008. ftp://ftp.irisa.fr/techreports/theses/2008/tsaidi.pdf.

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Thèse doctorat : Traitement du signal et télécommunications : Rennes 1 : 2008. Thèse doctorat : Traitement du signal et télécommunications : Université de Laval (Québec) : 2008.
Titre provenant de la page du titre du document électronique. Bibliogr. p. 177-182.

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Saidi, Taofik. "Architectures matérielles pour la technologie W-CDMA étendue aux systèmes multi-antennes". Rennes 1, 2008. ftp://ftp.irisa.fr/techreports/theses/2008/tsaidi.pdf.

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Depuis une dizaine d'années, l'avènement des systèmes multi-antennes (ou MIMO) pour les communications sans fil, mobiles ou fixes, a révolutionné les possibilités offertes pour de nombreux domaines d'application des télécommunications. La disposition de plusieurs antennes de part et d'autre du lien augmente considérablement la capacité des systèmes sans fil. Cependant, les algorithmes numériques à mettre en \oe uvre pour réaliser ces systèmes sont autrement complexes et constituent un challenge quant à la définition d'architectures matérielles performantes. L'objectif du travail présent repose précisément sur la définition optimale de solutions architecturales, dans un contexte CDMA, pour contrer cette problématique. Le premier aspect de ce travail porte sur une étude approfondie des algorithmes spatio-temporels et des méthodes de conception en vue d'une implantation matérielle efficace. De nombreux schémas de détection sont proposés dans la littérature et sont applicables suivant trois critères qui sont : la qualité de service, le débit binaire et la complexité algorithmique. Cette dernière constitue une contrainte forte pour une mise en application à faible coût de terminaux mobiles intégrant ces applications. Aussi, il est nécessaire de disposer d'outils performants pour simuler, évaluer et affiner (prototypage rapide) ces nouveaux systèmes, candidats probables pour les télécommunications de quatrième génération. Le second aspect concerne la réalisation d'un transcepteur multi-antennes sans codage de canal, intégrant la technologie d'accès multiple par répartition de codes dans le cas d'un canal large bande. Un système mono-antenne WCDMA, généralisable à un nombre quelconque d'antennes, a été intégré et simulé au sein de la plate-forme de prototypage rapide Lyrtech. L'architecture développée intègre les principaux modules du traitement en bande de base, à savoir le filtrage de Nyquist, la détection des multiples trajets suivie de l'étape de détection. Le prototype MIMO-WCDMA développé est caractérisé par sa flexibilité suivant le nombre de voies entrantes, le format d'entrée des échantillons, les caractéristiques du canal sans fil et la technologie ciblée (ASIC, FPGA). Le troisième aspect se veut plus prospectif en détaillant de nouveaux mécanismes pour réduire le coût matériel des systèmes multi-antennes. Le principe d'allocation adaptative de la virgule fixe est présenté dans le but d'adapter le codage des données suivant les caractéristiques du canal sans fil et de minimiser en conséquence la complexité du circuit. D'autre part, le concept d'architectures adaptatives est proposé afin de minimiser l'énergie consommée au sein d'un système embarqué suivant le contexte d'application
Over the last ten years, multi-antenna systems (MIMO) for mobile and fixed wireless communications have revolutionized the possibilities offered for numerous telecommunication application domains. Using multiple antennas at both ends of the link considerably increases the capacity of wireless systems. However, the digital algorithms needed to realize these systems are complex and constitute a challenge in order to define powerful hardware architectures. The goal of the present work centers specifically on the optimal definition of architectural solutions to combat this problem in a CDMA context. The first aspect of this work is a deepened study of space-time algorithms and design methods with regards to an efficient hardware implementation. Numerous detection schemes are proposed in the litterature and are applicable following three criteria : quality of service, binary throughput and algorithmic complexity. The latter constitutes a strong limitation for a low cost implementation of mobiles including these applications. Thus, it is necessary to use powerful tools to simulate, evaluate and rapidly prototype these new systems which constitute likely candidates for fourth generation telecommunication systems. The second aspect is the realization of an uncoded multi-antenna transceiver, integrating CDMA in a wideband channel case. A WCDMA mono-antenna system, generalized to any antenna array, has been integrated and simulated on the Lyrtech rapid prototyping platform. The developped architecture integrates the main baseband processing modules, such as Nyquist filtering, multiple path detection and detection itself. The MIMO-WCDMA prototype is characterized by its flexibility with regards to the number of inputs, format of samples, characteristics of the wireless channel and the targeted technology (ASIC, FPGA). The third aspect is more prospective since it introduces new methods to reduce the hardware cost of multi-antenna systems. The principle of dynamic allocation of the fixed point format is presented with the goal of adapting the data encoding according to the wireless channel's characteristics and consequently minimizing the circuit's complexity. Also, the concept of adaptive architectures is proposed to reduce the power consumption in an embedded system according to application context

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Rydman, William, e August Forsberg. "Teoretiska multiplar som investeringsstrategi : En kvantitativ studie om fundamentala värdedrivare och gapet mellan teori och praktik i relativvärdering". Thesis, Linköpings universitet, Institutionen för ekonomisk och industriell utveckling, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-170296.

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Title: Theoretical multiples as an investment strategy Authors: August Forsberg och William Rydman Supervisor: Øystein Fredriksen Background: Whether it is possible to generate excess return over time has been debated throughout the history and the results of previous research have found it possible. One approach to generate excess return is by using relative valuation. Even though there are theories on how to conduct the valuation method, a lot of actors in the market simplifies and misinterpret relative valuation. This leads onto the question if the gap between theory and practice has grown too big and if the common mistakes in relative valuation might be counteracted by calculating and using theoretical multiples as an investment strategy. Aim: The aim of this study is to analyze whether theoretical multiples can identify mispricing’s in the stock market. Further, the authors aim to examine if it is possible to generate excess return and a more accurate valuation by calculating the difference between theoretical- and reported multiples. Methodology: To achieve the aim of the study, a quantitative method with a deductive approach has been used. The study examines Swedish listed companies at OMX Stockholm Large Cap during the period 2008 to 2018. In order to evaluate the investment strategy, comparative portfolios have been designed based on the difference between theoretical and reported multiples. A total of eight portfolios have been constructed with low respectively high P/E, EV/EBITDA, P/BV and EV/Sales, where the portfolios are weighted once a year. Results: The study's results show that theoretical multiples work as an investment strategy for generating excess returns. In three out of four multiples, the overvalued shares performed better than the undervalued ones. By contrast, the undervalued shares generate higher riskadjusted returns than the overvalued ones. Although the psychological element in relative valuation is reduced by the investment strategy, the authors conclude that the share prices are largely influenced by other actors in the market. Key words: Efficient market hypothesis, Excess return, Investment strategies, Relative valuation, Multiples, Theoretical multiples, P/E, EV/EBITDA, P/BV, EV/Sales.
Titel: Teoretiska multiplar som investeringsstrategi Författare: August Forsberg och William Rydman Handledare: Øystein Fredriksen Bakgrund: Huruvida det är möjligt att generera överavkastning över tid har länge diskuterats och tidigare forskning menar att det är möjligt. Ett tillvägagångssätt för att generera överavkastning är att använda sig av relativvärdering. Trots att det finns teorier om hur värderingsmetoden ska genomföras, förenklas och misstolkas relativvärdering ofta av aktörer på marknaden. Det leder in på frågan om gapet mellan teori och praktik har blivit för stort samt om värderingsmetodens fallgropar kan motverkas genom beräkningen av teoretiska multiplar som investeringsstrategi. Syfte: Syftet med studien är att analysera om teoretiska multiplar kan identifiera felprissättningar på marknaden. Vidare ämnar studien att undersöka om det genom att beräkna differensen mellan teoretiska- och redovisade multiplar går att generera överavkastning och en mer precis värdering. Metod: För att uppnå syftet med studien har en kvantitativ metod med deduktiv ansats använts. Studien undersöker bolag noterade på OMX Stockholm Large Cap under perioden 2008 till 2018. För att utvärdera investeringsstrategin har jämförelseportföljer utifrån differensen mellan teoretiska och redovisade multiplar utformats. Totalt har åtta portföljer konstruerats med låga respektive höga P/E, EV/EBITDA, P/BV och EV/Sales där portföljerna viktas om en gång per år. Resultat: Studiens resultat visar att teoretiska multiplar fungerar som investeringsstrategi för att generera överavkastning. I tre av fyra multiplar har de övervärderade aktierna presterat bättre än de undervärderade. Däremot genererar de undervärderade aktierna högre riskjusterad avkastning än de övervärderade. Även om det psykologiska inslaget i relativvärdering minskas av investeringsstrategin, blir författarnas slutsats att aktiekurserna till stor del påverkas av andra aktörer på marknaden. Sökord: Effektiva marknadshypotesen, Överavkastning, Investeringsstrategi, Relativvärdering, Multiplar, Teoretiska multiplar, P/E, EV/EBITDA, P/BV, EV/Sales.

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Zaske, Jörg [Verfasser]. "Identifizierung und Unterdrückung multipler Reflexionen unter Verwendung der Wellenfrontcharakteristik = Identification and attenuation of multiple reflections using wavefront characteristics / Jörg Zaske". Karlsruhe : KIT-Bibliothek, 2000. http://d-nb.info/1013933850/34.

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Enders, Heidi Verfasser], Jochen [Akademischer Betreuer] [Musch e Ute [Akademischer Betreuer] Bayen. "Wissensdiagnostik mit Multiple-Choice und Multipler Evaluation - ein Vergleich logarithmischer und linearer Auswertefunktionen / Heidi Enders. Gutachter: Jochen Musch ; Ute Bayen". Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2011. http://d-nb.info/1018072373/34.

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Duarte, Pollyanna Domeny. "Mieloma múltiplo estudo do microambiente e correlação com fatores prognósticos /". Botucatu, 2020. http://hdl.handle.net/11449/192727.

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Orientador: Maria Aparecida Custodio Domingues
Resumo: Mieloma Múltiplo é uma neoplasia maligna de células plasmocitárias, cujas repercussões clínicas de interação da célula tumoral com seu microambiente e com o hospedeiro podem causar danos irreversíveis e progressivos ao doente. Estratégias terapeuticas têm tentado reunir antídotos às várias linhas de atuação da célula tumoral. Objetivou-se avaliar características clíncas e possíveis interações com o microambiente da medula óssea. Foram colhidos dados clínicos, reavaliado material histológico e confeccionado bloco de TMA com grupos de pacientes ao diagnóstico, na primeira recaída e após transplante autólogo de medula óssea. A análise estatística compreendeu descrição dos dados de distribuições de frequência para as variáveis qualitativas e calculadas as médias, desvios padrão, valores mínimo e máximo e mediana para as variáveis quantitativas. O teste de Qui-quadrado de Pearson foi empregado para variáveis qualitativas. Gráficos do tipo mosaico apresentaram os cruzamentos das variáveis discretas e técnica FAMD para verificação da contribuição das variáveis qualitativas e quantitativas simultaneamente. As curvas de sobrevida foram obtidas usando a metodologia de Kaplan & Meier e a estatística de Breslow foi empregada para testar a diferença entre as curvas observadas. Os intervalos de confiança para as curvas e testes foram feitos com nível de significância de 5%. As análises e figuras foram elaboradas com o software R (R Core Team, 2017). Concluímos que pacientes com condições c... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Multiple Myeloma is a malignant neoplasm of plasma cells whose clinical repercussions of tumor cell interaction with its microenvironment and host may cause irreversible and progressive damage to the patient. Therapeutic strategies have attempted to gather antidotes to the various lines of action of the tumor cell. This study aimed to evaluate clinical characteristics and possible interactions with the bone marrow microenvironment. Clinical data were collected, histological material was reevaluated and an AMT block was made with patient groups at diagnosis, in the first relapse and after autologous bone marrow transplantation. Statistical analysis included description of frequency distribution data for qualitative variables and calculated means, standard deviations, minimum and maximum values and median for quantitative variables. Pearson's chi-square test was used for qualitative variables. Mosaic graphs showed the intersections of discrete variables and FAMD technique to verify the contribution of qualitative and quantitative variables simultaneously. Survival curves were obtained using the Kaplan & Meier methodology and the Breslow statistic was employed to test the difference between the observed curves. Confidence intervals for curves and tests were made at a significance level of 5%. The analyzes and figures were elaborated with the R software (R Core Team, 2017).We conclude that patients with clinical conditions for more aggressive initial therapies may impact their su... (Complete abstract click electronic access below)
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Bouilloc, Thomas. "Applications de décompositions tensorielles à l'identification de modèles de Volterra et aux systèmes de communication MIMO-CDMA". Nice, 2011. http://www.theses.fr/2011NICE4048.

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Les décompositions tensorielles font l’objet d’intérêts croissants, dans de nombreux domaines d’application, notamment le traitement du signal, depuis plusieurs années. Ce succès s’explique par la nature multidimensionnelle des données à traiter, comme c’est le cas par exemple, pour les signaux émis et reçus dans les systèmes de communication sans fil. Ce succès croissant s’explique également par les propriétés mathématiques que présentent les outils tensoriels, notamment en termes d’unicité. Dans une première partie, nous abordons les opérations et modèles tensoriels requis pour les présents travaux de thèse. Dans une seconde partie, nous traitons de nouvelles méthodes permettant de réduire la complexité paramétrique des modèles de Volterra complexes. En considérant les noyaux de Volterra d’ordre supérieur à un comme des tenseurs symétriques, nous utilisons plusieurs décompositions tensorielles pour réduire considérablement la complexité paramétrique des noyaux. Une étude comparative, par l’intermédiaire de simulations de Monte Carlo, évalue les performances des algorithmes mis en œuvre en termes de précision, de complexité, et de sensibilité au bruit. Par la suite, en considérant les noyaux de Volterra d’ordre supérieur à un comme des tenseurs symétriques, nous utilisons la décomposition CP/PARAFAC pour formuler les modèles de Volterra-PARAFAC, qui impliquent une réduction de complexité paramétrique considérable. Nous montrons que ces modèles peuvent être vus comme une série de modèles de Wiener mis en parallèle. Finalement, nous proposons trois méthodes d’identification récursives : le filtre de Kalman étendu complexe (ECKF), l’algorithme des moindres carrés moyens complexe (CLMS), puis sa version normalisée (NCLMS). Des résultats de simulation de Monte Carlo sont présentés pour illustrer les performances des algorithmes d’estimation proposés dans le cas de systèmes de Volterra complexes cubiques excités par des signaux de communication PSK. Nous étendrons les résultats précédents au cas des modèles de Volterra passe-bande, utilisés pour la modélisation de canaux non linéaires. Ainsi, nous développons une nouvelle classe de modèles de Volterra, appelés modèles de Volterra-PARAFAC passe-bande, de complexité paramétrique réduite, en faisant appel à une décomposition CP/PARAFAC doublement symétrique des noyaux de Volterra. Des algorithmes adaptatifs similaires au cas des modèles de Volterra-PARAFAC sont proposés pour l’estimation paramétrique des modèles de Volterra-PARAFAC passe-bande. Des résultats de simulation illustrent le comportement des méthodes d’identification proposées. Dans un premier temps, nous considérons un système de communication coopératif, en supposant que les matrices de code des utilisateurs sont mutuellement orthogonales et connues à la réception. Cette hypothèse nous permet de séparer et décoder simultanément les signaux des utilisateurs, ce qui nous amène à considérer deux approches : une approche semi-aveugle avec estimation du canal durant une phase d’apprentissage, suivie d’une récupération des symboles pour chaque utilisateur, pendant une phase aveugle ; une approche aveugle, caractérisée par une seule phase, qui estime de manière conjointe le canal et des symboles, pour chaque utilisateur. Des résultats de simulation sont fournis pour illustrer les performances des récepteurs aveugles et semi-aveugles. Nous considérons également le cas de figure où les matrices de code des utilisateurs sont inconnues à la réception. Ainsi nous proposons une approche semi-aveugle avec une phase d’apprentissage qui estime conjointement les matrices de code et de canal des utilisateurs, suivie d’une phase aveugle qui récupère leurs symboles
This thesis concerns both the theoretical and constructive resolution of inverse problems for isotropic diffusion equation in planar domains, simply and doubly connected. From partial Cauchy boundary data (potential, flux), we look for those quantities on the remaining part of the boundary, where no information is available, as well as inside the domain. The proposed approach proceed by considering solutions to the diffusion equation as real parts of complex valued solutions to some conjugated Beltrami equation. These particular generalized analytic functions allow to introduce Hardy classes, where the inverse problems is stated as a best constrained approximation issue (bounded extremal problem), and thereby is regularized. Hence, existence and smoothness properties, together with density results of traces on the boundary, ensure well-posedness. An application is studied, to a free boundary problem for magnetically confined plasma in the tokamak Tore Supra (CEA-IRFM Caldarache). The resolution of the approximation problem on a suitable basis of functions (toroidal harmonics) lead to a qualification criterion for the estimated plasma boundary. A descent algorithm makes it decrease, and refines the estimations. The methods do not require any integration of the solution in the overall domain. It furnishes very accurate numerical results, and could be extended to other devices, like JET ou ITER

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Thiery, Gwendoline. "Imagerie par désorption laser/spectrométrie de masse de multiples marqueurs spécifiques : développement de la technique TAMSIM "Targeted Multiplex Mass Spectrometry Imaging"". Paris 6, 2008. http://www.theses.fr/2008PA066253.

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La protéomique est devenue un domaine de recherche essentiel en biologie et en médecine. Afin, de répondre aux enjeux de cette discipline, il est nécessaire de pouvoir caractériser et localiser les protéines exprimées au niveau cellulaire. De nombreuses techniques d’analyses in situ des ces protéines considérées comme étant des marqueurs spécifiques d’une pathologie existent et sont utilisées en routine, notamment pour le suivi des cancers, dans de nombreux laboratoires d’anatomo pathologie. La plus répandue est l’immunohistochimie (IHC). Cette technique consiste à révéler spécifiquement in situ un complexe immun (antigène-anticorps). Dans l’optique d’accroître la capacité de détection multiple (multiplexage) d’une immunoréaction, nous avons développé une nouvelle technique d’imagerie in situ de multiples marqueurs spécifiques. Des traceurs chimiques photoclivables (Tag) sont fixés spécifiquement sur des anticorps. Les anticorps marqués sont complexés in situ aux protéines cibles présentent sur le tissu. Les Tag sont ensuite clivés de leurs anticorps respectifs par désorption laser. Apres une irradiation de la coupe par le laser à 355 nm une image est générée à partir des différents spectres de masse enregistrés pour chaque Tag utilisés. Contrairement au mode MALDI, l’utilisation de la matrice n’est pas nécessaire pour favoriser l’ionisation de ces composés chimiques. Ce qui simplifie grandement l’analyse par spectrométrie de masse. Cette technique appelée TAMSIM pour TArgeted multiplex Mass Spectrometry IMaging a pu être validée pour l’analyse de différents marqueurs spécifiques localisés au sein des tissus pancréatiques et sur des sections tissulaires de foie humain.

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Gullström, Cecilia. "Pictionary Physics: En kvalitativ undersökning av ett didaktiskt verktyg i enlighet med The Scholarship of Teaching and Learning". Thesis, Uppsala universitet, Institutionen för fysik och astronomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212721.

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Den här undersökningen inom fysikdidaktik utförs enligt ramverket The Scholarship of Teaching and Learning (SoTL). Det didaktiska verktyget som ska utvärderas benämns Pictionary Physics. Studien börjar med en litteraturöversikt av multipla representationer och interaktivt engagemang. Översikten syftar till att utforska hur lärandet kan möjliggöras vid användningen av det didaktiska verktyget. Pictionary Physics användes sedan för att främja en interaktiv användning av multipla representationer i en grupp bestående av fyra studenter. Studenternas agerande studerades och analyserades kvalitativt, följt av en utvärdering av studenternas upplevelser när de använde det didaktiska verktyget. Utvärderingen visar att Pictionary Physics kan gynna konceptuell förståelse för begrepp inom fysik. Utvärderingen visar även att det didaktiska verktyget skulle kunna bidra till förbättrat studieresultat då studenter uppmuntras att använda multipla representationer på ett interaktivt sätt. Fortsatt förädling av Pictionary Physics föreslås. Detta är stommen för SoTL, där tanken är att konsekvent utöka var kunskap om lärandet av fysik.
This physics education research project is carried out following the framework of the Scholarship of Teaching and Learning (SoTL). The didactic instrument investigated is termed Pictionary Physics. The study begins with a literature review of research on multiple representation, and interactive engagement. This review is used to evaluate the learning potential of the intended didactic instrument. Pictionary Physics was then used to facilitate the multi-representational interaction of a group of four physics students. The students’ behavior was studied and analyzed qualitatively, followed by an evaluation of the students’ experiences when using this didactic instrument. The investigation shows that Pictionary Physics may promote conceptual understanding of physics phenomena. The investigation also implies that this didactic instrument can contribute to improved learning outcomes when students are encouraged to interact by using multiple representations. Continued refinement of the Pictionary Physics concept is suggested. Such refinement is the essence of SoTL, incrementally expanding our knowledge of the teaching and learning of physics.

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Brunel, Lionel. "Vers une réintroduction de l’efficacité mnésique : l’apport des modèles à traces multiples". Thesis, Lyon 2, 2010. http://www.theses.fr/2010LYO20055/document.

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Nombreuses sont les situations où notre mémoire nous fait défaut. A qui n’est-il jamais arrivé de se retrouver face à une personne sans se rappeler son prénom ? Pourtant vous savez que vous connaissez ce visage et que vous êtes même capables de resituer la dernière fois où vous l’avez déjà vu. A l’inverse, vous pouvez être sûr d’avoir déjà rencontré une personne alors que c’est la première fois que vous la voyez… Pour autant, dans ces deux situations, vous n’avez jamais oublié ce qu’était un visage. Tout en étant faillible dans certaines situations, l’efficacité de notre mémoire reste bien souvent inaperçue. Cette thèse propose de traiter la question de l’efficacité mnésique dans une modélisation particulière de la mémoire : les modèles à traces multiples. Nous traiterons de l’apport de cette notion à l’approche développée par Versace et collaborateurs (2002 ; 2009). Cette dernière suppose que les connaissances émergent d’un système unique de mémoire à partir de l’activation et de l’intégration de traces mnésiques épisodiques multimodales et distribuées.Suivant cette approche, il apparaît que l’efficacité dans les activités catégorielles s’explique par une relation de similarité entre un indice à traiter et un grand nombre de traces en mémoire, alors que l’efficacité dans les tâches discriminantes implique que l’indice à traiter active non seulement une quantité restreinte de traces mais surtout que celles-ci soient suffisamment intégrées. L’étude de l’efficacité nous a permis de mettre en évidence deux types d’intégration : une intégration qui participe directement à l’émergence des connaissances (à la conscience), et une intégration qui participe au maintien des propriétés de l’expérience perceptive et motrice au sein d’une trace. De plus, il semblerait que, quel que soit le traitement, l’efficacité dépend de ce que l’indice active à la fois des propriétés au sein et entre les traces.A l’issue de cette thèse, nous sommes arrivés à la conclusion que l’efficacité mnésique dépend du type de tâche, de la force du liage entre les éléments de la trace et d’une relation interactive entre l’indice à traiter et les traces en mémoire
There are many situations where our memory fails us. Who is it ever happened to meet face to one and not remember his name? Yet you are sure that you know this face and you're even able to retrieve the last time you've seen it. Conversely, you can be sure you have already met one person while it is the first time you see it... However, in both situations, you have never forgotten what a face is. While being fallible in some situations, the memory accuracy is often overlooked. This thesis proposes to address the issue of memory accuracy in a particular model of memory: multi-traces theory. We discuss the contribution of this question to the approach developed by Versace and collaborators (2002, 2009). This implies that knowledge emerging from a single memory from the activation and integration of distributed multimodal episodic memory traces.According to this approach, it appears that the accuracy in the categorical tasks is due to a similarity relationship between a cue and a large number of memory traces. While accuracy in discriminating tasks involves that a cue activate a limited number of traces, but also these ones need to be sufficiently integrated. Studying accuracy has allowed us to identify two kinds of integration: integration directly involved in the emergence of the knowledge (to the consciousness), and integration which ensures that former perceptivo-motor experience is encoded within a trace. Moreover, it seems that each kind of processing depends on the probability that a cue activates features within and between the traces.Finally, we can say that the accuracy depends on the type of memory task, the strength of binding between the trace components, and an interactive relationship between the cue and memory traces

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41

Clerk-Lamalice, Julien. "Étude de l'incidence des coïncidences triples simulées et mesurées à partir de systèmes TEP pixélisés sur les critères de qualité d'image". Mémoire, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6029.

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Résumé : En tomographie d'émission par positrons (TEP), les données sont enregistrées par la détection de paires de photons de haute énergie (511~keV) en coïncidence. Or, dans un système de détection pixélisé, comme celui des scanners LabPET, la diffusion Compton dans les cristaux voisins entraîne la détection fréquente d'événements multiples, présentement rejetés dans le processus de reconstruction des images. Ces événements multiples peuvent augmenter l'efficacité de détection du scanner de façon significative, mais il reste à démontrer que l'inclusion de ces coïncidences peut améliorer la sensibilité sans affecter les critères de qualité des images, tels que la résolution spatiale et le contraste. Le but du projet est de démontrer l'influence de l'inclusion de ces événements dans le processus de reconstruction d'images. Les méthodes à critères fixes seront utilisées pour sélectionner les coïncidences triple obtenues à partir de données simulées à l’aide du logiciel de simulation GATE (« Geant4 Application for Tomographic Emission ») et de mesures réelles effectuées sur les scanners LabPET. // Abstract : In positron emission tomography, data are acquired by detecting pairs of high energy photons (511 keV) in coincidence. Thus, in a highly pixelated system such as the LabPET scanner, Compton diffusion in neighboring crystals can trigger the detection of multiple events (multiple coincidences) which are currently rejected from the reconstruction process. These multiple events can increase significantly the scanner’s detection efficiency, but it remains to be demonstrated that they can be used to increase sensitivity in the images without decreasing image quality criteria, such as the spatial resolution and contrast. The goal of this work is to demonstrate the influence of including these events in the image reconstruction process. Fixed criteria methods were used to select triple coincidences obtained from simulated data from the GATE (Geant4 Application for Tomography Emission) software and real measurements from the LabPET scanner.

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42

Boman, Martin. "Temperaturloggning i multipla zoner". Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-104158.

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För att på ett effektivt sätt kunna reglera miljön i en byggnad krävs god tillgång till pålitlig data. Den inledande arkitekturen för ett system som ska klara av att mäta luftkvalité och värme i en byggnad tas fram i detta projekt. Projeket fokuserar på att ta fram arkitekturen för temperaturmätning men ser till att öppna för möjligheten för att bygga ut den framtagna arkitekturen med fler sensorer.
To accurately regulate the indoor environment of a building requires good access to reliable data. This project aims to develop the baseline architecture for a system that is able to measure air quality and temperature in a given building. This project focuses on developing the architecture for temperature measuring while opening for the possibility of adding more components and sensors to the developed architecture.

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43

Hellvin, Sebastian. "Förmågor i uppgiftskonstruktion : En analys av uppgiftskonstruktioner i svenskämnet i relation till teorin om multipla intelligenser". Thesis, Linnéuniversitetet, Institutionen för utbildningsvetenskap (UV), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-62619.

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I denna studie undersöks hur svensklärares uppgiftskonstruktioner möter elevers olika förmågor. Med utgångspunkt i Gardners teori om multipla intelligenser definierade jag olika kategorier av förmågor som motsvarade de olika intelligenserna i tretton olika uppgiftskonstruktioner för svenskämnet i gymnasieskolan. Studien visar att den lingvistiska förmågan är absolut vanligast i det undersökta materialet, vilket också var väntat. Men de personliga förmågorna är också vanligt förkommande, vilket visar att lärarna begär att eleverna ska dela sina egna tankar, minnen och upplevelser. Den lingvistiska förmågan fungerar i uppgifterna vanligen som metod, men i det stoff eleverna skriver om är de personliga förmågorna långt vanligare än den lingvistiska.
This study examines how the tasks constructed by teachers of Swedish meet the pupils’ differing abilities. Based on Gardner’s theory of multiple intelligences, I defined different categories of abilities corresponding to the different intelligences in thirteen different tasks constructed for the subject of Swedish in upper secondary school. The study shows that linguistic ability is by far the most common in the studied material, as expected. But personal abilities are also commonly found, which shows that the teachers ask the pupils to share of their own thoughts, memories and experiences. The linguistic ability usually functions in the tasks as a method, but in the material that the pupils write, the personal abilities are far more common than the linguistic ability.

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44

Öhlin, Victoria, e Vanja Sakotic. "Multiplar som investeringsstrategi : En kvantitativ studie om bolag på Stockholmsbörsen mellan åren 2008- 2018". Thesis, Linköpings universitet, Företagsekonomi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158416.

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Bakgrund: Det finns olika investeringsstrategier som investerare kan använda sig av, att investera i låga multiplar är en strategi som har studerats väl. Genom att använda sig av låga multiplar kan investerare finna undervärderade bolag som på sikt genererar en överavkastning gentemot marknaden. Syfte: Studiens syfte är att analysera hur väl P/E, P/B, P/S, EV/EBIT, EV/EBITDA och EV/S multiplarna skulle kunna appliceras som investeringsstrategi på Stockholmsbörsen. Vidare ämnar studien åt att analysera om det är möjligt att generera en högre avkastning än vad indexet OMXSPI har avkastat under tidsperioden 2008-2018. Metod: Studien använder sig av en kvantitativ forskningsstrategi där två portföljer för respektive multipel har sammanställts. Portföljerna viktas om årligen och både den verkliga och den ackumulerade avkastningen beräknas fram. Vidare utvärderas portföljerna enligt utvärderingsmåtten Sharpekvot, M^2, Treynorkvot och Jensens Alpha. Resultat: Investeringsstrategin är implementerbar för tre av sex multiplar. Låga P/B, EV/EBIT och EV/EBITDA genererade en överavkastning och slog både index samt respektive hög portfölj. Medan för de resterande multiplarna P/E, P/S och EV/S resulterade det i att investeringsstrategin inte är implementerbar. EV/S hade den högsta riskjusterade överavkastning och presterade bäst av samtliga sex multiplar. Studieresultatet för samtliga multiplar kan statistiskt säkerställas med en signifikansnivå på 5%. Den månatliga portföljavkastningen är inte slumpmässig, utan marknadsavkastningen har en viss påverkan.
Background: There are several investment strategies investors can use, where the strategy to invest in low multiples is well studied. By using low multiples investors can find undervalued companies to generate an excess return. Previous studies have been focusing on the P/E and EV/EBITDA- multiples, and not as much on other used multiples in relative valuation. Therefore an interest exists to also analyze multiples such as P/B, P/S, EV/EBIT and EV/S. Purpose: The study’s purpose is to analyze how well the multiples P/E, P/B, P/S, EV/EBIT, EV/EBITDA and EV/S can be applied as an investment strategy in the Stockholm Stock Exchange. Furthermore the study aim to analyze the possibility to generate a higher return than the index OMXSPI during the time period 2008-2018. Method: The study uses a quantitative research strategy, where two portfolios for each multiple has been created. The portfolio has been reinvested once a year, both the real and accumulated return was calculated. Also, the portfolios’ performance has been evaluated by adjusting it to risk by using the Sharpe ratio, M^2 , Treynor ratio and Jensen’s Alpha. Result: The investment strategy can be implemented for three of six multiples. The low P/B, EV/EBIT and EV/EBITDA generated a higher return than both index and their respective high portfolio. The other multiples P/E, P/S and EV/S cannot be used as an investment strategy. The high EV/S portfolio had the highest risk adjusted excess return meanwhile P/S had the highest accumulated return. The result of all multiples has been found to be statistically significant, therefore the market return has an effect on the portfolios’ monthly return.

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45

Yilmaz, Mehmet. "Multiple Target Tracking Using Multiple Cameras". Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12609477/index.pdf.

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Video surveillance has long been in use to monitor security sensitive areas such as banks, department stores, crowded public places and borders. The rise in computer speed, availability of cheap large-capacity storage devices and high speed network infrastructure enabled the way for cheaper, multi sensor video surveillance systems. In this thesis, the problem of tracking multiple targets with multiple cameras has been discussed. Cameras have been located so that they have overlapping fields of vision. A dynamic background-modeling algorithm is described for segmenting moving objects from the background, which is capable of adapting to dynamic scene changes and periodic motion, such as illumination change and swaying of trees. After segmentation of foreground scene, the objects to be tracked have been acquired by morphological operations and connected component analysis. For the purpose of tracking the moving objects, an active contour model (snakes) is one of the approaches, in addition to a Kalman tracker. As the main tracking algorithm, a rule based tracker has been developed first for a single camera, and then extended to multiple cameras. Results of used and proposed methods are given in detail.

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46

Gasparri, Roberto <1968&gt. "Tumori primitivi multipli del polmone. Profilo clinico e biologico in pazienti affetti da neoplasie polmonari multiple. Analisi di elementi clinici e marcatori biologici come possibili fattori di differenziazione dei tumori polmonari multipli". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3655/.

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Background: MPLC represents a diagnostic challenge. Topic of the discussion is how to distinguish these patients as a metastatic or a multifocal disease. While in case of the different histology there are less doubt on the opposite in case of same histology is mandatory to investigate on other clinical features to rule out this question. Matherials and Methods: A retrospective review identified all patients treated surgically for a presumed diagnosis of SPLC. Pre-operative staging was obtained with Total CT scan and fluoro-deoxy positron emission tomography and mediastinoscopy. Patients with nodes interest or extra-thoracic location were excluded from this study. Epidermal growth factor receptor (EGFR) expression with complete immunohistochemical analisis was evaluated. Survival was estimated using Kaplan-Meyer method, and clinical features were estimated using a long-rank test or Cox proportional hazards model for categorical and continuous variable, respectively. Results: According to American College Chest Physician, 18 patients underwent to surgical resection for a diagnosis of MPLC. Of these, 8 patients had 3 or more nodules while 10 patients had less than 3 nodules. Pathologic examination demonstrated that 13/18(70%) of patients with multiple histological types was Adenocarcinoma, 2/18(10%) Squamous carcinoma, 2/18(10%) large cell carcinoma and 1/18(5%) Adenosquamosu carcinoma. Expression of EGFR has been evaluated in all nodules: in 7 patients of 18 (38%) the percentage of expression of each nodule resulted different. Conclusions: MPLC represent a multifocal disease where interactions of clinical informations with biological studies reinforce the diagnosis. EGFR could contribute to differentiate the nodules. However, further researches are necessary to validate this hypothesis.

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Antunes, Nilson. "Influencia da ultrafiltração na remoção de mediadores inflamatorios durante circulação extracorporea e alterações da função organica monitorada pelo "Sequencial Organ Failure Assessment Score - SOFA" em pacientes submetidos a revascularização do miocar". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313474.

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Orientador: Desanka Dragosavac, Luis Alberto Magna
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-14T08:33:07Z (GMT). No. of bitstreams: 1 Antunes_Nilson.pdf: 1392711 bytes, checksum: 89e9cd241a2037104655c013c2724bfc (MD5) Previous issue date: 2009
Resumo: Objetivo: Investigar a eficácia da ultrafiltração na remoção de mediadores inflamatórios liberados pela circulação extracorpórea e correlacionar ultrafiltração com alterações da função orgânica de acordo com o "Seqüential Organ Failure Assessment Score". Métodos: Quarenta pacientes foram incluídos e randomizados em dois grupos: "sem ultrafiltração" (n=20; Grupo I) e "ultrafiltração" (n=20; Grupo II). Complementos 3 e 4 ativados, interleucina 1beta, 6, 8 e fator de necrose tumoral alfa foram dosados antes da indução anestésica (T1), 5 minutos antes da circulação extracorpórea (T2), no líquido ultrafiltrado (T3), 30 minutos (T4), 6 (T5), 12 (T6), 24 (T7), 36 (T8) e 48 (T9) horas após término da circulação extracorpórea. "Sequential Organ Failure Assessment Score" foi avaliado nos tempos 1, 6 e 9. Significância estatística foi estabelecida com p = 0,05. Resultados: No líquido ultrafiltrado, apenas níveis de fator de necrose tumoral alfa foram detectados. Níveis de complemento 3 ativado, nos tempos 5 e 7, e complemento 4 ativado, nos tempos 5 e 6, foram significativamente elevados no grupo sem ultrafiltração, e níveis de interleucina 6 foram elevados no grupo ultrafiltrado, nos tempos 7 e 8. Interleucina 1beta, 8, fator de necrose tumoral alfa, e "Sequential Organ Failure Assessment Score" não tiveram diferenças significantes entre os grupos. Conclusões: Ultrafiltração retira significativamente fator de necrose tumoral alfa, mas isto não influencia nos níveis séricos desta citocina. Ultrafiltração com o tipo de filtro usado neste estudo não filtra outros mediadores inflamatórios estudados e não diminui a disfunção orgânica no pós-operatório. Deverá ser usada apenas para controle volêmico nos pacientes submetidos à circulação extracorpórea.
Abstract: Objective: To investigate the effectiveness of ultrafiltration in removing inflammatory mediators released by cardiopulmonary bypass and to correlate ultrafiltration with alterations in organic function according to the Sequential Organ Failure Assessment Score. Methods: Forty patients were included and randomized into two groups: "no ultrafiltration" (n=20; Group I) and "ultrafiltration" (n=20; Group II). Activated complement 3 and 4, interleukins 1beta, 6, 8 and tumor necrosis factor alfa were measured prior to anesthesia induction (Time 1), 5 minutes before cardiopulmonary bypass (Time 2), in the ultrafiltrated fluid (Time 3), 30 minutes (Time 4), and 6 (Time 5), 12 (Time 6), 24 (Time 7), 36 (Time 8) and 48 (Time 9) hours following cardiopulmonary bypass. Sequential Organ Failure Assessment Score was evaluated at Time 1, 6 and 9. Statistical significance was established at p = 0.05. Results: In the ultrafiltrated fluid, only tumor necrosis factor alfa levels were detected. Levels of activated complement 3 at Times 5 and 7 and activated complement 4 at Times 5 and 6 were significantly higher in the unfiltered Group, and levels of interleukin 6 were higher in the filtered Group at Times 7 and 8. Interleukins 1beta, 8, tumor necrosis factor alfa, and the Sequential Organ Failure Assessment score were not significantly different between the groups. Conclusions: Ultrafiltration significantly filtered tumor necrosis factor alfa but did not influences serum levels of this cytokine. Ultrafiltration with the type of filter used in this study had no effect in organic dysfunction and should be used only for volemic control in patients undergoing cardiopulmonary bypass.
Universidade Estadual de Campi
Pesquisa Experimental
Doutor em Cirurgia

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48

Genné, Myriam [Verfasser]. "Betrachtung der Adhärenz von Patienten mit Multipler Sklerose unter immunmodulatorischer Therapie und deren Einflussgrößen in einem ambulanten Multiple Sklerose Zentrum / Myriam Genné". Ulm : Universität Ulm. Medizinische Fakultät, 2011. http://d-nb.info/1016659814/34.

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Silva, Hugleibson Bernardo da. "A utilização do multiplano no ensino de geometria para alunos do ensino fundamental com deciência visual". Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4837.

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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
In mathematics, when you can associate the concrete with the abstract, reap many fruits. Especially if in the classes are present students with visual impairment. Given the di culties encountered to teach Plane Geometry on Elementary School, this work has as its main objective to introduce the Multiplane as an alternative teaching of Plane Geometry, not only for people with visual impairment, but for all students, to improve learning as well as increase their interest on classes. The research also included a brief study on visual impairment, advances in legislation for inclusion of people with disabilities in the education system and the Braille code. Were also suggested some activities, adapted to the Multiplane.
Na matemática, quando se consegue associar o concreto com o abstrato, colhem-se muitos frutos. Principalmente se nas turmas estão presentes alunos com de ciência visual. Dada as di culdades encontradas para ensinar Geometria Plana no Ensino Fundamental, este trabalho tem como objetivo principal apresentar o Multiplano como alternativa de ensino de Geometria Plana, não só para portadores de de ciência visual, e sim para todos os alunos, visando melhorar a aprendizagem bem como aumentar o interesse dos mesmos nas aulas. A pesquisa contemplou, também, um breve estudo sobre a de ciência visual, os avanços na legislação para inclusão de de cientes no sistema de ensino e o código Braille. Foram também sugeridas algumas atividades, adaptadas para o Multiplano.

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Gaul, Leander. "Molekulare Wirkmechanismen beim Multiplen Myelom". Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-93603.

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