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Articoli di riviste sul tema "Muscle cells"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Griffin, D. M., H. M. Hudson, A. Belhaj-Saïf, B. J. McKiernan, and P. D. Cheney. "Do Corticomotoneuronal Cells Predict Target Muscle EMG Activity?" Journal of Neurophysiology 99, no. 3 (2008): 1169–986. http://dx.doi.org/10.1152/jn.00906.2007.

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Data from two rhesus macaques were used to investigate the pattern of cortical cell activation during reach-to-grasp movements in relation to the corresponding activation pattern of the cell's facilitated target muscles. The presence of postspike facilitation (PSpF) in spike-triggered averages (SpTAs) of electromyographic (EMG) activity was used to identify cortical neurons with excitatory synaptic linkages with motoneurons. EMG activity from 22 to 24 muscles of the forelimb was recorded together with the activity of M1 cortical neurons. The extent of covariation was characterized by 1) identi

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2

Becker, S., G. Pasca, D. Strumpf, L. Min, and T. Volk. "Reciprocal signaling between Drosophila epidermal muscle attachment cells and their corresponding muscles." Development 124, no. 13 (1997): 2615–22. http://dx.doi.org/10.1242/dev.124.13.2615.

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Directed intercellular interactions between distinct cell types underlie the basis for organogenesis during embryonic development. This paper focuses on the establishment of the final somatic muscle pattern in Drosophila, and on the possible cross-talk between the myotubes and the epidermal muscle attachment cells, occurring while both cell types undergo distinct developmental programs. Our findings suggest that the stripe gene is necessary and sufficient to initiate the developmental program of epidermal muscle attachment cells. In stripe mutant embryos, these cells do not differentiate corre

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3

Reyes, Morayma, and Jeffrey S. Chamberlain. "Perivascular CD45−:Sca-1+:CD34− Cells Are Derived from Bone Marrow Cells and Participate in Dystrophic Skeletal Muscle Regeneration." Blood 106, no. 11 (2005): 394. http://dx.doi.org/10.1182/blood.v106.11.394.394.

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Abstract Multiple mechanisms may account for bone marrow (BM) cell incorporation into myofibers following muscle damage. Here, we demonstrated that CD45−:Sca-1+:CD34− cells may play a role in the regeneration of mdx4cv skeletal muscles, an animal model for Duchenne muscular dystrophy. To understand the origin of CD45−:Sca-1+:CD34− cells in skeletal muscle, we reconstituted lethally irradiated wild type (wt) or mdx4cv mice with unfractionated BM cells from transgenic mice ubiquitously expressing green fluorescence protein (GFP). 1, 2, and 6 months post-transplantation, we analyzed the skeletal

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4

Yoshimoto, Momoko, Toshio Heike, Mitsutaka Shiota, Hirohiko Kobayashi, Katsutsugu Umeda, and Tatsutoshi Nakahata. "Hematopoietic Stem Cells Can Give Rise to Satellite-Like Cells in Skeletal Muscles." Blood 104, no. 11 (2004): 2690. http://dx.doi.org/10.1182/blood.v104.11.2690.2690.

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Abstract Recent studies have indicated that bone marrow cells can regenerate damaged muscles, but also that they can adopt phenotype of other cells by cell fusion. It has also been reported that single hematopoietic stem cells (HSCs) can regenerate skeletal muscle although it is still controversial whether HSCs differentiate into satellite cells in muscle or not. In order to investigate the roles of HSCs in muscle regeneration and whether they can generate satellite cells or not, we purified and injected CD45+Lin−Sca-1+c-kit+(CD45+KSL) HSCs labeled by green fluorescent protein (GFP) into mice

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5

Heslop, L., J. E. Morgan, and T. A. Partridge. "Evidence for a myogenic stem cell that is exhausted in dystrophic muscle." Journal of Cell Science 113, no. 12 (2000): 2299–308. http://dx.doi.org/10.1242/jcs.113.12.2299.

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Injection of the myotoxin notexin, was found to induce regeneration in muscles that had been subjected to 18 Gy of radiation. This finding was unexpected as irradiation doses of this magnitude are known to block regeneration in dystrophic (mdx) mouse muscle. To investigate this phenomenon further we subjected mdx and normal (C57Bl/10) muscle to irradiation and notexin treatment and analysed them in two ways. First by counting the number of newly regenerated myofibres expressing developmental myosin in cryosections of damaged muscles. Second, by isolating single myofibres from treated muscles a

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6

Azab, Azab. "Skeletal Muscles: Insight into Embryonic Development, Satellite Cells, Histology, Ultrastructure, Innervation, Contraction and Relaxation, Causes, Pathophysiology, and Treatment of Volumetric Muscle I." Biotechnology and Bioprocessing 2, no. 4 (2021): 01–17. http://dx.doi.org/10.31579/2766-2314/038.

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Background: Skeletal muscles are attached to bone and are responsible for the axial and appendicular movement of the skeleton and for maintenance of body position and posture. Objectives: The present review aimed to high light on embryonic development of skeletal muscles, histological and ultrastructure, innervation, contraction and relaxation, causes, pathophysiology, and treatment of volumetric muscle injury. The heterogeneity of the muscle fibers is the base of the flexibility which allows the same muscle to be used for various tasks from continuous low-intensity activity, to repeated subma

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7

Zikic, Dragan, Slobodan Stojanovic, Mirjana Djukic-Stojcic, Zdenko Kanacki, Verica Milosevic, and Gordana Uscebrka. "Morphological characteristics of breast and thigh muscles of slow- and medium growing strains of chickens." Biotehnologija u stocarstvu 32, no. 1 (2016): 27–35. http://dx.doi.org/10.2298/bah1601027z.

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Morphological characteristics of skeletal muscles of slow- and medium-growing strains of chickens are very important for meat quality and comparison with fast-growing strains. The aim of this paper was to evaluate morphological parameters of breast and thigh muscles of slow- and mediumgrowing strains in a free-range system. The slow-growing strains used in the experiment were autochthonous breeds Sombor crested and Banat naked neck, and the medium-growing strain was Red-bro. The tissue samples were taken from the thigh muscle and muscles of the breast of 10 chickens of each breed. Samples were

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8

Zhang, Zihao, Shudai Lin, Wen Luo, et al. "Sox6 Differentially Regulates Inherited Myogenic Abilities and Muscle Fiber Types of Satellite Cells Derived from Fast- and Slow-Type Muscles." International Journal of Molecular Sciences 23, no. 19 (2022): 11327. http://dx.doi.org/10.3390/ijms231911327.

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Adult skeletal muscle is primarily divided into fast and slow-type muscles, which have distinct capacities for regeneration, metabolism and contractibility. Satellite cells plays an important role in adult skeletal muscle. However, the underlying mechanisms of satellite cell myogenesis are poorly understood. We previously found that Sox6 was highly expressed in adult fast-type muscle. Therefore, we aimed to validate the satellite cell myogenesis from different muscle fiber types and investigate the regulation of Sox6 on satellite cell myogenesis. First, we isolated satellite cells from fast- a

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9

Zhao, Shudong, Jishizhan Chen, Lei Wu, Xin Tao, Naheem Yaqub, and Jinke Chang. "Induced Pluripotent Stem Cells for Tissue-Engineered Skeletal Muscles." International Journal of Molecular Sciences 24, no. 14 (2023): 11520. http://dx.doi.org/10.3390/ijms241411520.

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Abstract (sommario):

Skeletal muscle, which comprises a significant portion of the body, is responsible for vital functions such as movement, metabolism, and overall health. However, severe injuries often result in volumetric muscle loss (VML) and compromise the regenerative capacity of the muscle. Tissue-engineered muscles offer a potential solution to address lost or damaged muscle tissue, thereby restoring muscle function and improving patients’ quality of life. Induced pluripotent stem cells (iPSCs) have emerged as a valuable cell source for muscle tissue engineering due to their pluripotency and self-renewal

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10

Fukuda, K., Y. Tanigawa, G. Fujii, S. Yasugi, and S. Hirohashi. "cFKBP/SMAP; a novel molecule involved in the regulation of smooth muscle differentiation." Development 125, no. 18 (1998): 3535–42. http://dx.doi.org/10.1242/dev.125.18.3535.

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During embryogenesis, smooth muscle cells of the gut differentiate from mesenchymal cells derived from splanchnic mesoderm. We have isolated a gene involved in the differentiation of smooth muscle cells in the gut using differential display between the chicken proventriculus in which the smooth muscle layer develops poorly and the gizzard in which smooth muscles develop abundantly. The protein encoded by this gene showed highest similarity to mouse FK506 binding protein, FKBP65, and from the function of this protein it was designated chicken FKBP/smooth muscle activating protein (cFKBP/SMAP).

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11

Mitchell, Patrick O., and Grace K. Pavlath. "Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells." American Journal of Physiology-Cell Physiology 287, no. 6 (2004): C1753—C1762. http://dx.doi.org/10.1152/ajpcell.00292.2004.

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Atrophy of skeletal muscle leads to decreases in myofiber size and nuclear number; however, the effects of atrophic conditions on muscle precursor cells (MPC) are largely unknown. MPC lie outside myofibers and represent the main source of additional myonuclei necessary for muscle growth and repair. In the present study, we examined the properties of MPC after hindlimb suspension (HS)-induced atrophy and subsequent recovery of the mouse hindlimb muscles. We demonstrated that the number of MPC in atrophied muscles was decreased. RT-PCR analysis of cells isolated from atrophied muscles indicated

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12

Ardizzi, J. P., and H. F. Epstein. "Immunochemical localization of myosin heavy chain isoforms and paramyosin in developmentally and structurally diverse muscle cell types of the nematode Caenorhabditis elegans." Journal of Cell Biology 105, no. 6 (1987): 2763–70. http://dx.doi.org/10.1083/jcb.105.6.2763.

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The nematode Caenorhabditis elegans contains two major groups of muscle cells that exhibit organized sarcomeres: the body wall and pharyngeal muscles. Several additional groups of muscle cells of more limited mass and spatial distribution include the vulval muscles of hermaphrodites, the male sex muscles, the anal-intestinal muscles, and the gonadal sheath of the hermaphrodite. These muscle groups do not exhibit sarcomeres and therefore may be considered smooth. Each muscle cell has been shown to have a specific origin in embryonic cell lineages and differentiation, either embryonically or pos

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13

Challa, Stalin Reddy, and Swathi Goli. "Differentiation of Human Embryonic Stem Cells into Engrafting Myogenic Precursor Cells." Stem cell Research and Therapeutics International 1, no. 1 (2019): 01–05. http://dx.doi.org/10.31579/2643-1912/002.

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Degenerative muscle diseases affect muscle tissue integrity and function. Human embryonic stem cells (hESC) are an attractive source of cells to use in regenerative therapies due to their unlimited capacity to divide and ability to specialize into a wide variety of cell types. A practical way to derive therapeutic myogenic stem cells from hESC is lacking. In this study, we demonstrate the development of two serum-free conditions to direct the differentiation of hESC towards a myogenic precursor state. Using TGFß and PI3Kinase inhibitors in combination with bFGF we showed that one week of diffe

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14

Mañas-García, Laura, Maria Guitart, Xavier Duran, and Esther Barreiro. "Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin." Nutrients 12, no. 6 (2020): 1870. http://dx.doi.org/10.3390/nu12061870.

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We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading for seven days following a seven-day period of hindlimb immobilization with/without curcumin or resveratrol treatment, progenitor muscle cell numbers (FACS), satellite cell subtypes (histology), early and late muscle regeneration markers, phenotype and morphometry, sirtuin-1 activity and content, and muscle function were assessed. Treatment with either resveratrol or curcumin

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15

Szewczyk, N. J., J. J. Hartman, S. J. Barmada, and L. A. Jacobson. "Genetic defects in acetylcholine signalling promote protein degradation in muscle cells of Caenorhabditis elegans." Journal of Cell Science 113, no. 11 (2000): 2003–10. http://dx.doi.org/10.1242/jcs.113.11.2003.

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A myosin-lacZ fusion, expressed in 103 muscle cells of Caenorhabditis elegans, reports on how proteolysis in muscle is controlled by neural and intramuscular signals. Upon acute starvation, the fusion protein is degraded in the posterior 63 cells of the body-wall muscle, but remains stable in 32 anterior body-wall muscles and 8 vulval muscle cells. This distinction correlates with differences in the innervation of these cells. Reporter protein in the head and vulval muscles becomes labile upon genetic ‘denervation’ in mutants that have blocks in pre-synaptic synthesis or release of acetylcholi

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16

Torrente, Yuan, Jacques-P. Tremblay, Federica Pisati, et al. "Intraarterial Injection of Muscle-Derived Cd34+Sca-1+ Stem Cells Restores Dystrophin in mdx Mice." Journal of Cell Biology 152, no. 2 (2001): 335–48. http://dx.doi.org/10.1083/jcb.152.2.335.

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Duchenne muscular dystrophy is a lethal recessive disease characterized by widespread muscle damage throughout the body. This increases the difficulty of cell or gene therapy based on direct injections into muscles. One way to circumvent this obstacle would be to use circulating cells capable of homing to the sites of lesions. Here, we showed that stem cell antigen 1 (Sca-1), CD34 double-positive cells purified from the muscle tissues of newborn mice are multipotent in vitro and can undergo both myogenic and multimyeloid differentiation. These muscle-derived stem cells were isolated from newbo

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17

Connor, E. A., and U. J. McMahan. "Cell accumulation in the junctional region of denervated muscle." Journal of Cell Biology 104, no. 1 (1987): 109–20. http://dx.doi.org/10.1083/jcb.104.1.109.

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If skeletal muscles are denervated, the number of mononucleated cells in the connective tissue between muscle fibers increases. Since interstitial cells might remodel extracellular matrix, and since extracellular matrix in nerve and muscle plays a direct role in reinnervation of the sites of the original neuromuscular junctions, we sought to determine whether interstitial cell accumulation differs between junctional and extrajunctional regions of denervated muscle. We found in muscles from frog and rat that the increase in interstitial cell number was severalfold (14-fold for frog, sevenfold f

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18

CIECIERSKA, ANNA, TOMASZ SADKOWSKI, and TOMASZ MOTYL. "Role of satellite cells in growth and regeneration of skeletal muscles." Medycyna Weterynaryjna 75, no. 11 (2019): 6349–2019. http://dx.doi.org/10.21521/mw.6349.

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Postnatal growth and regeneration capacity of skeletal muscles is dependent mainly on adult muscle stem cells called satellite cells. Satellite cells are quiescent mononucleated cells that are normally located outside the sarcolemma within the basal lamina of the muscle fiber. Their activation, which results from injury, is manifested by mobilization, proliferation, differentiation and, ultimately, fusion into new muscle fibers. The satellite cell pool is responsible for the remarkable regenerative capacity of skeletal muscles. Moreover, these cells are capable of self-renewal and can give ris

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19

Balch, Ying. "Subculture human skeletal muscle cells to produce the cells with different Culture medium compositions." Clinical Research and Clinical Trials 3, no. 4 (2021): 01–03. http://dx.doi.org/10.31579/2693-4779/036.

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This study aimed to subculture human skeletal muscle cells (HSkMC) using a culture medium with different compositions to determine the most efficient medium for the growth of the human skeletal muscle cells. The culture media was divided into three groups: Group1. An HSkMC growth medium. Group 2. An HSkMC growth medium + with 10% high glucose (GH). Group 3. An HSkMC growth medium + 10% fetal bovine serum (FBS). HSkMC from groups 1 to 3 gradually became round in shape and gathered in clusters. These changes differed between the groups. In group 3, the HSkMC clusters were more in numbers and gat

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20

Rosenberg, N. L., and B. L. Kotzin. "Aberrant expression of class II MHC antigens by skeletal muscle endothelial cells in experimental autoimmune myositis." Journal of Immunology 142, no. 12 (1989): 4289–94. http://dx.doi.org/10.4049/jimmunol.142.12.4289.

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Abstract We recently described the induction of an inflammatory myopathy in SJL/J mice after injection of skeletal muscle Ag and adjuvant that is characterized by necrosis of muscle fibers associated with infiltrating mononuclear cells. In the present study, an immunohistologic analysis was performed to examine the phenotype of these infiltrating cells and to determine changes in cell-surface Ag expression in involved muscle. The predominant cells infiltrating muscle after induction of experimental autoimmune myositis (EAM) were found to be Mac-1+/I-A+ macrophages, representing 80 to 90% of al

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21

Čížková, Dana, J. Vávrová, S. Mičuda, et al. "Role of Transplanted Bone Marrow Cells in Response to Skeletal Muscle Injury." Folia Biologica 57, no. 6 (2011): 232–41. http://dx.doi.org/10.14712/fb2011057060232.

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The recently discovered capacity of bone marrow cells (BMCs) to contribute to injury-induced skeletal muscle regeneration has brought new possibilities in the treatment of skeletal muscle diseases. However, a suitable method of BMC transplantation usable for such therapy has to be established. In this work, recipient mice were intramuscularly injected with cardiotoxin, then whole-body lethally irradiated to eradicate satellite cells in their injured tibialis anterior (TA) muscles and to suppress haematopoiesis, and subsequently intravenously transplanted with lacZ+ BMCs with the aim to investi

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Robson, L. G. "Cellular patterning of fast and slow fibres in the intermandibularis muscle of chick embryos." Development 117, no. 1 (1993): 329–39. http://dx.doi.org/10.1242/dev.117.1.329.

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The way in which the pattern of cell types arises during development of individual muscles was explored. The pattern of cellular differentiation resulting from the synthesis of particular fast and slow myosin heavy chains (MyHC) was investigated in the intermandibularis muscle in the lower jaw of chick embryos. The intermandibularis muscle has a proximodistal pattern of fibre type distribution. The distal region of the muscle contains a ratio of 1.5:1 fast to slow muscle fibres, which increases to &gt; 2.5:1 in the proximal region. The intermandibularis muscle is assembled in a proximodist

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Muskiewicz, Kristina R., Natasha Y. Frank, Alan F. Flint, and Emanuela Gussoni. "Myogenic Potential of Muscle Side and Main Population Cells after Intravenous Injection into Sub-lethally Irradiated mdx Mice." Journal of Histochemistry & Cytochemistry 53, no. 7 (2005): 861–73. http://dx.doi.org/10.1369/jhc.4a6573.2005.

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Muscle side population (SP) cells have demonstrated hematopoietic and myogenic activities in vivo upon intravenous (IV) injection into lethally irradiated mdx mice. In contrast, muscle main population (MP) cells were unable to rescue the bone marrow of lethally irradiated mice and, consequently, their in vivo myogenic potential could not be assessed using this method. In the current study, muscle SP or MP cells derived from syngeneic wild-type male mice were delivered to sub-lethally irradiated mdx female mice by single or serial IV injections. Recipient mice were euthanized 12 weeks after tra

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Sanders, Kenton M., Sean M. Ward, and Sang Don Koh. "Interstitial Cells: Regulators of Smooth Muscle Function." Physiological Reviews 94, no. 3 (2014): 859–907. http://dx.doi.org/10.1152/physrev.00037.2013.

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Smooth muscles are complex tissues containing a variety of cells in addition to muscle cells. Interstitial cells of mesenchymal origin interact with and form electrical connectivity with smooth muscle cells in many organs, and these cells provide important regulatory functions. For example, in the gastrointestinal tract, interstitial cells of Cajal (ICC) and PDGFRα+cells have been described, in detail, and represent distinct classes of cells with unique ultrastructure, molecular phenotypes, and functions. Smooth muscle cells are electrically coupled to ICC and PDGFRα+cells, forming an integrat

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Carvajal Monroy, P. L., S. Grefte, A. M. Kuijpers-Jagtman, J. W. Von den Hoff, and F. A. D. T. G. Wagener. "Neonatal Satellite Cells Form Small Myotubes In Vitro." Journal of Dental Research 96, no. 3 (2016): 331–38. http://dx.doi.org/10.1177/0022034516679136.

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Although palatal muscle reconstruction in patients with cleft palate takes place during early childhood, normal speech development is often not achieved. We hypothesized that the intrinsic properties of head satellite cells (SCs) and the young age of these patients contribute to the poor muscle regeneration after surgery. First, we studied the fiber type distribution and the expression of SC markers in ex vivo muscle tissue from head (branchiomeric) and limb (somite-derived) muscles from neonatal (2-wk-old) and young (9-wk-old) rats. Next, we cultured SCs isolated from these muscles for 5, 7,

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Morgan, Jennifer E., and Terence A. Partridge. "Muscle satellite cells." International Journal of Biochemistry & Cell Biology 35, no. 8 (2003): 1151–56. http://dx.doi.org/10.1016/s1357-2725(03)00042-6.

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Visan, Ioana. "Muscle Treg cells." Nature Immunology 15, no. 2 (2014): 142. http://dx.doi.org/10.1038/ni.2818.

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Tedgui, Alain, and Ziad Mallat. "Smooth Muscle Cells." Circulation Research 87, no. 2 (2000): 81–82. http://dx.doi.org/10.1161/01.res.87.2.81.

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Relaix, Frédéric, and Christophe Marcelle. "Muscle stem cells." Current Opinion in Cell Biology 21, no. 6 (2009): 748–53. http://dx.doi.org/10.1016/j.ceb.2009.10.002.

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Feige, Peter, and Michael A. Rudnicki. "Muscle stem cells." Current Biology 28, no. 10 (2018): R589—R590. http://dx.doi.org/10.1016/j.cub.2018.02.064.

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Goldring, Kirstin, Terence Partridge, and Diana Watt. "Muscle stem cells." Journal of Pathology 197, no. 4 (2002): 457–67. http://dx.doi.org/10.1002/path.1157.

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Broadie, K. S., and M. Bate. "The development of adult muscles in Drosophila: ablation of identified muscle precursor cells." Development 113, no. 1 (1991): 103–18. http://dx.doi.org/10.1242/dev.113.1.103.

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Abstract (sommario):

A small subset of mesodermal cells continues to express twist in the late embryo of Drosophila. These cells are the precursors of adult muscles. Each late twist-expressing cell begins to divide early in the second larval instar and division continues throughout the second and third instars, resulting in a small clone of twist-expressing cells at puparium formation. Treatment with a DNA-synthesis inhibitor, hydroxyurea (HU), ablates these cells if applied during S-phase of their replication cycle. We ablated twist-expressing lineages in the larva and demonstrated that this results in the absenc

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Cevik, Hilal, Isabelle Gangadin, Justin G. Boyer, Douglas Millay, and Stephen N. Waggoner. "Key contribution of NK cells to inflammation after muscle injury." Journal of Immunology 208, no. 1_Supplement (2022): 165.14. http://dx.doi.org/10.4049/jimmunol.208.supp.165.14.

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Abstract Immune activation after tissue injury is required for removal of dead cells and debris to permit subsequent regenerative healing. Natural killer (NK) cells are innate lymphocytes that are essential for immune defense and for regulation of inflammation. NK cells limit fibrosis after cardiac muscle damage, yet the role of these cells during skeletal muscle inflammation is less clear. We hypothesize that NK cells promote acute inflammation after muscle damage but that NK cell responses must be resolved to permit regenerative healing. Following bilateral injection of cardiotoxin into tibi

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Dumont, Nicolas A., C. Florian Bentzinger, Marie‐Claude Sincennes, and Michael A. Rudnicki. "Satellite Cells and Skeletal Muscle Regeneration." Comprehensive Physiology 5, no. 3 (2015): 1027–59. https://doi.org/10.1002/j.2040-4603.2015.tb00646.x.

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Abstract (sommario):

ABSTRACTSkeletal muscles are essential for vital functions such as movement, postural support, breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic multinucleated fibers. The life‐long maintenance of muscle tissue is mediated by satellite cells, lying in close proximity to the muscle fibers. Muscle satellite cells are a heterogeneous population with a small subset of muscle stem cells, termed satellite stem cells. Under homeostatic conditions all satellite cells are poised for activation by stimuli such as physical trauma or growth signals. After activation, sat

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Čížková, Dana, Z. Komárková, A. Bezrouk, et al. "Bone Marrow-Derived Cells Participate in Composition of the Satellite Cell Niche in Intact and Regenerating Mouse Skeletal Muscle." Folia Biologica 64, no. 5 (2018): 155–66. http://dx.doi.org/10.14712/fb2018064050155.

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Abstract (sommario):

The cellular components of the satellite cell niche participate in the regulation of skeletal muscle regeneration. Beside myogenic cells at different developmental stages, this niche is formed by cells of the immune system, the interstitial connective tissue and the vascular system. Unambiguous determination of the origin of these cell types could contribute to optimization of the cell-based therapy of skeletal muscle disorders. In our work, we intravenously transplanted mouse GFP+ unseparated bone marrow cells into whole-body lethally irradiated immunocompetent mice four weeks before cardioto

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Yamane, Akira, Satonari Akutsu, Thomas G. H. Diekwisch, and Ryoichi Matsuda. "Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice." American Journal of Physiology-Cell Physiology 289, no. 1 (2005): C42—C48. http://dx.doi.org/10.1152/ajpcell.00577.2004.

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Abstract (sommario):

To determine whether muscle satellite cells and utrophin are correlated with the degree of damage in mdx skeletal muscles, we measured the area of the degenerative region as an indicator of myofiber degeneration in the masseter, gastrocnemius, soleus, and diaphragm muscles of mdx mice. Furthermore, we analyzed the expression levels of the paired box homeotic gene 7 ( pax7), m-cadherin (the makers of muscle satellite cells), and utrophin mRNA. We also investigated the immunolocalization of m-cadherin and utrophin proteins in the muscles of normal C57BL/10J (B10) and mdx mice. The expression lev

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Medvedev, M. A., M. B. Baskakov, S. V. Gusakova, et al. "Mechanisms of regulation electric and contractile activity smooth muscle cells: the role of cytoskeleton." Bulletin of Siberian Medicine 7, no. 4 (2008): 31–37. http://dx.doi.org/10.20538/1682-0363-2008-4-31-37.

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Abstract (sommario):

The influence of modulation of cytoskeleton by colchicine, vinblastine, cytochalasine B and docetaxel on contractile reactions of smooth muscle cells caused by electric stimulus, depolarization, phenylephrine has been investigated by the mechanographical method, by the methods of the double sucrose gup junction. It is established, that induced by a isoosmotic hyperpotassium solution of reduction of smooth muscle of the rat’s aorta, and also caused depolarization stimulus potentials of action and reductions smooth muscle cells from guinea pig urethra, depend more on the condition of microfilame

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38

Eržen, Ida. "PLASTICITY OF SKELETAL MUSCLE STUDIED BY STEREOLOGY." Image Analysis & Stereology 23, no. 3 (2011): 143. http://dx.doi.org/10.5566/ias.v23.p143-152.

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Abstract (sommario):

The present contribution provides an overview of stereological methods applied in the skeletal muscle research at the Institute of Anatomy of the Medical Faculty in Ljubljana. Interested in skeletal muscle plasticity we studied three different topics: (i) expression of myosin heavy chain isoforms in slow and fast muscles under experimental conditions, (ii) frequency of satellite cells in young and old human and rat muscles and (iii) capillary supply of rat fast and slow muscles. We analysed the expression of myosin heavy chain isoforms within slow rat soleus and fast extensor digitorum longus

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39

Harfe, B. D., C. S. Branda, M. Krause, M. J. Stern, and A. Fire. "MyoD and the specification of muscle and non-muscle fates during postembryonic development of the C. elegans mesoderm." Development 125, no. 13 (1998): 2479–88. http://dx.doi.org/10.1242/dev.125.13.2479.

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Abstract (sommario):

Basic-helix-loop helix factors of the myoD/myf5/ myogenin/MRF4 family have been implicated in acquisition and elaboration of muscle cell fates. Here we describe both myogenic and non-myogenic roles for the Caenorhabditis elegans member of this family (CeMyoD) in postembryonic mesodermal patterning. The postembryonic mesodermal lineage in C. elegans provides a paradigm for many of the issues in mesodermal fate specification: a single mesoblast ('M') divides to generate 14 striated muscles, 16 non-striated muscles, and two non-muscle cells. To study CeMyoD function in the M lineage, we needed to

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40

Contreras-Muñoz, Paola, Joan Ramón Torrella, Vanessa Venegas, et al. "Muscle Precursor Cells Enhance Functional Muscle Recovery and Show Synergistic Effects With Postinjury Treadmill Exercise in a Muscle Injury Model in Rats." American Journal of Sports Medicine 49, no. 4 (2021): 1073–85. http://dx.doi.org/10.1177/0363546521989235.

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Abstract (sommario):

Background: Skeletal muscle injuries represent a major concern in sports medicine. Cell therapy has emerged as a promising therapeutic strategy for muscle injuries, although the preclinical data are still inconclusive and the potential clinical use of cell therapy has not yet been established. Purpose: To evaluate the effects of muscle precursor cells (MPCs) on muscle healing in a small animal model. Study Design: Controlled laboratory study. Methods: A total of 27 rats were used in the study. MPCs were isolated from rat (n = 3) medial gastrocnemius muscles and expanded in primary culture. Ske

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41

Morawin, Barbara, and Agnieszka Zembroń-Łacny. "Role of endocrine factors and stem cells in skeletal muscle regeneration." Postępy Higieny i Medycyny Doświadczalnej 75 (June 2, 2021): 371–84. http://dx.doi.org/10.5604/01.3001.0014.9125.

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Abstract (sommario):

The process of reconstructing damaged skeletal muscles involves degeneration, inflammatory and immune responses, regeneration and reorganization, which are regulated by a number of immune-endocrine factors affecting muscle cells and satellite cells (SCs). One of these molecules is testosterone (T), which binds to the androgen receptor (AR) to initiate the expression of the muscle isoform of insulin-like growth factor 1 (IGF-1Ec). The interaction between T and IGF-1Ec stimulates the growth and regeneration of skeletal muscles by inhibiting apoptosis, enhancement of SCs proliferation and myoblas

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42

Volk, T., and K. VijayRaghavan. "A central role for epidermal segment border cells in the induction of muscle patterning in the Drosophila embryo." Development 120, no. 1 (1994): 59–70. http://dx.doi.org/10.1242/dev.120.1.59.

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Abstract (sommario):

The correct patterning of muscles in the Drosophila embryo depends on the migration of developing muscles over the ectoderm and on the attachment of these muscles to specific attachment sites. We investigate the mechanisms that are involved in this process and describe experiments that allow a genetic dissection of the role of the ectoderm in muscle migration and attachment. We show that cells along the segmental border in the ectoderm are used by the developing muscles to reach their attachment sites. These segment border cells are recognized by dissociated myotubes in single suspensions in c

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43

Park, Jinryong, Jeongeun Lee, Ki-Duk Song, et al. "Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes." Animal Bioscience 34, no. 8 (2021): 1392–402. http://dx.doi.org/10.5713/ab.20.0585.

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Abstract (sommario):

Objective: The growth rate of pigs is related to differentiation and proliferation of muscle cells, which are regulated by growth factors and expression of growth-related genes. Thus, the objective of this study was to establish optimal culture conditions for Jeju black pig (JBP) muscle cells and determine the relationship of various factors involved in muscle growth with the proliferation of JBP muscle cells. Methods: Muscles were taken from the femur skeletal muscle of JBP embryos. After isolation of the muscle cells, cells were cultured in a 6-well plate under four different culture conditi

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44

Deyhle, Michael R., Chandler S. Callaway, Daria Neyroud, Andrew C. D’Lugos, Sarah M. Judge, and Andrew R. Judge. "Depleting Ly6G Positive Myeloid Cells Reduces Pancreatic Cancer-Induced Skeletal Muscle Atrophy." Cells 11, no. 12 (2022): 1893. http://dx.doi.org/10.3390/cells11121893.

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Abstract (sommario):

Immune cells can mount desirable anti-cancer immunity. However, some immune cells can support cancer disease progression. The presence of cancer can lead to production of immature myeloid cells from the bone marrow known as myeloid-derived suppressor cells (MDSCs). The immunosuppressive and pro-tumorigenic effects of MDSCs are well understood. Whether MDSCs are involved in promoting cancer cachexia is not well understood. We orthotopically injected the pancreas of mice with KPC cells or PBS. One group of tumor-bearing mice was treated with an anti-Ly6G antibody that depletes granulocytic MDSCs

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45

Tatsumi, Ryuichi, Xiaosong Liu, Antonio Pulido, et al. "Satellite cell activation in stretched skeletal muscle and the role of nitric oxide and hepatocyte growth factor." American Journal of Physiology-Cell Physiology 290, no. 6 (2006): C1487—C1494. http://dx.doi.org/10.1152/ajpcell.00513.2005.

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Abstract (sommario):

In the present study, we examined the roles of hepatocyte growth factor (HGF) and nitric oxide (NO) in the activation of satellite cells in passively stretched rat skeletal muscle. A hindlimb suspension model was developed in which the vastus, adductor, and gracilis muscles were subjected to stretch for 1 h. Satellite cells were activated by stretch determined on the basis of 5-bromo-2′-deoxyuridine (BrdU) incorporation in vivo. Extracts from stretched muscles stimulated BrdU incorporation in freshly isolated control rat satellite cells in a concentration-dependent manner. Extracts from stretc

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46

Rushton, E., R. Drysdale, S. M. Abmayr, A. M. Michelson, and M. Bate. "Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development." Development 121, no. 7 (1995): 1979–88. http://dx.doi.org/10.1242/dev.121.7.1979.

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Abstract (sommario):

We have used mutations in the newly identified gene myoblast city to investigate the founder cell hypothesis of muscle development in Drosophila melanogaster. In embryos mutant for myoblast city the fusion of myoblasts into multinucleate muscles is virtually abolished. Nevertheless, a subset of the myoblasts develop specific muscle-like characteristics, including gene expression appropriate to particular muscles, migration to the appropriate part of the segment, correct position and orientation, and contact by motor neurons. We suggest that this subset of myoblasts represents the proposed musc

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47

Nelson, J. S., M. A. Meredith, and B. E. Stein. "Does an extraocular proprioceptive signal reach the superior colliculus?" Journal of Neurophysiology 62, no. 6 (1989): 1360–74. http://dx.doi.org/10.1152/jn.1989.62.6.1360.

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Abstract (sommario):

1. The primary functions of the superior colliculus (SC) are thought to include both the spatial localization of sensory stimuli and the initiation of an orienting response. It has been hypothesized that, in cat, both of these SC functions may be influenced by feedback from the extraocular muscles. The present investigation was initiated to determine which SC cells receive this extraocular muscle feedback and how this feedback influences the discharge properties of SC cells and their ability to integrate input from other sensory modalities. These questions were addressed in cats prepared with

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48

Sanders, Kenton M., Yoshihiko Kito, Sung Jin Hwang, and Sean M. Ward. "Regulation of Gastrointestinal Smooth Muscle Function by Interstitial Cells." Physiology 31, no. 5 (2016): 316–26. http://dx.doi.org/10.1152/physiol.00006.2016.

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Abstract (sommario):

Interstitial cells of mesenchymal origin form gap junctions with smooth muscle cells in visceral smooth muscles and provide important regulatory functions. In gastrointestinal (GI) muscles, there are two distinct classes of interstitial cells, c-Kit+interstitial cells of Cajal and PDGFRα+cells, that regulate motility patterns. Loss of these cells may contribute to symptoms in GI motility disorders.

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49

Fukada, So-ichiro, Yuko Miyagoe-Suzuki, Hiroshi Tsukihara, et al. "Muscle regeneration by reconstitution with bone marrow or fetal liver cells from green fluorescent protein-gene transgenic mice." Journal of Cell Science 115, no. 6 (2002): 1285–93. http://dx.doi.org/10.1242/jcs.115.6.1285.

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Abstract (sommario):

The myogenic potential of bone marrow and fetal liver cells was examined using donor cells from green fluorescent protein (GFP)-gene transgenic mice transferred into chimeric mice. Lethally irradiated X-chromosome-linked muscular dystrophy (mdx) mice receiving bone marrow cells from the transgenic mice exhibited significant numbers of fluorescence+ and dystrophin+ muscle fibres. In order to compare the generating capacity of fetal liver cells with bone marrow cells in neonatal chimeras,these two cell types from the transgenic mice were injected into busulfantreated normal or mdx neonatal mice,

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50

Nobuyoshi, Masaharu, Akihiro Kume, Hiroaki Mizukami, et al. "Hematopoietic Transdifferentiation of Muscle-Derived Cells after In Vivo Transient Expression of MSX1 Transcription Factor." Blood 104, no. 11 (2004): 2689. http://dx.doi.org/10.1182/blood.v104.11.2689.2689.

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Abstract (sommario):

Abstract After a considerable dispute, it was shown that cells with hematopoietic activity in muscles are derived from hematopoietic organ. Transdifferentiation is not a frequent event, if any, and such a phenomenon cannot be applied to tissue regeneration easily. To achieve a breakthrough, we explored the possibility that genetic manipulation may enhance the efficiency of transdifferentiation. In this regard, there is a notable report that transient overexpression of a homeobox-containing transcriptional repressor Msx1 in muscles generated abundant mononuclear cells (MNCs) capable of differen

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