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Tesi sul tema "Neurons"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 25 luglio 2025

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1

Moonens, Sofie. "Mirror Neurons : The human mirror neuron system." Thesis, Högskolan i Skövde, Institutionen för kommunikation och information, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-6103.

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Abstract (sommario):
This literature review explores human mirror neurons from several angles. First it retells mirror neuron history, from the initial discovery in the macaque monkey research through to the experiments determining if there is a human brain homologue. Then the merits of two opposing evolutionary views – mirror neurons as an adaptation or an association, here referring to an adaptation’s byproduct – are discussed. Lastly the autistic mirror neuron dysfunction hypothesis – stating that a faulty mirror neuron system is at the basis of autistic behavioral patterns – is examined for its validity but ul
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2

Steinbush, H. W. M. "Het neuron als bruggenbouwer "bridging disciplines by neurons" /." Maastricht : Maastricht : Instituut hersenen en gedrag ; University Library, Universiteit Maastricht [host], 1999. http://arno.unimaas.nl/show.cgi?fid=12984.

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3

Moubarak, Estelle. "Constraints imposed by morphological and biophysical properties of axon and dendrites on the electrical behaviour of rat substantia nigra pars compacta dopaminergic neurons." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0746.

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Abstract (sommario):
L’activité électrique des neurones est déterminée par des interactions complexes entre leurs propriétés morphologiques et biophysiques. Les neurones dopaminergiques (DA) de la substance noire compacte (SNc) présentent une caractéristique morphologique peu commune parmi les neurones de mammifères: leur axone émerge fréquemment d’une dendrite à une distance très variable du soma. Malgré cette importante variabilité dans la localisation de l’axone, peu d’articles ont étudié un lien potentiel entre morphologie neuronale et activité électrique dans ces cellules. Dans un premier article, nous avons
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4

Serrat, Reñé Román. "Papel de Alex3 en la vía de señalización de Wnt y en la dinámica mitocondrial." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83338.

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La proteína Alex3 forma parte de la familia de genes exclusiva de los mamíferos euterios Armcx, caracterizada por presentar una alta expresión en el SNC, por encontrarse localizada en clúster en el cromosoma X y porque se originaron a partir de la retrotransposición del gen Armc10 y una rápida duplicación en tándem en una evolución temprana de los mamíferos euterios. Las proteínas Armcx/Armc10 poseen primariamente una localización subcelular bimodal, encontrándose asociadas a la membrana externa mitocondrial y en el núcleo celular, localización que concuerda con sus secuencias proteicas que po
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5

Wilson, Jennifer M. M. "Mechanisms of neuronal integration in adrenomedullary sympathetic preganglionic neurons." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6334.

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Sympathetic preganglionic neurons innervating the adrenal medulla (AD-SPN) regulate the release of adrenal catecholamines into the bloodstream. This research was undertaken to investigate the intrinsic properties and synaptic pathways characteristic of AD-SPN in neonatal rat spinal cord slice preparation. The presence of Lucifer Yellow from the patch pipette and Rhodamine-Dextran-Lysine from the adrenal medulla in the same neuron post recording identified AD-SPN. Active intrinsic properties revealed and characterised include: a potassium-mediated transient outward rectification present in 96%
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6

Ganguly, Karunesh. "Activity-dependent regulation of neuronal excitability in hippocampal neurons /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2002. http://wwwlib.umi.com/cr/ucsd/fullcit?p3059903.

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7

Avó, Freixo Francisco Duque Projecto. "Novel roles for the mitotic kinase Nek7 in hippocampal neurons." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399540.

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Abstract (sommario):
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such as their stability, polarity and dynamics, are spatially and temporally regulated by several factors, including post-translational modifications, stabilizing/destabilizing MAPs, motors, kinases, phosphatases, etc. Many of these factors were identified in cycling cells and particularly during mitosis. Nevertheless, some bona-fide mitotic microtubule regulators are also expressed in differenti
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8

Stanke, Jennifer J. "Beyond Neuronal Replacement: Embryonic Retinal Cells Protect Mature Retinal Neurons." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1250820277.

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9

Bonifazi, Paolo. "Information processing in dissociated neuronal cultures of rat hippocampal neurons." Doctoral thesis, SISSA, 2005. http://hdl.handle.net/20.500.11767/4080.

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Abstract (sommario):
One of the major aims of Systems Neuroscience is to understand how the nervous system transforms sensory inputs into appropriate motor reactions. In very simple cases sensory neurons are immediately coupled to motoneurons and the entire transformation becomes a simple reflex, in which a noxious signal is immediately transformed into an escape reaction. However, in the most complex behaviours, the nervous system seems to analyse in detail the sensory inputs and is performing some kind of information processing (IP). IP takes place at many different levels of the nervous system: from the peri
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10

Albrecht, David. "Efectos de la proteína SPARC sobre la maduración de las sinapsis autápticas colinérgicas." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/107673.

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Abstract (sommario):
Las sinapsis son un elemento clave para el funcionamiento del sistema nervioso y la formación de las sinapsis es un proceso decisivo a lo largo de la vida. El establecimiento de los contactos sinápticos ocurre tanto en el sistema nervioso en desarrollo como en el cerebro adulto. Durante todo este proceso las neuronas y las células gliales se encuentran íntimamente acopladas por todo el sistema nervioso. Las investigaciones de las últimas décadas han evidenciado que las células gliales poseen un rol que va más allá del clásicamente atribuido, demostrando que la glía posee una función relevante
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11

Kuebler, Eric Stephen. "Harnessing the Variability of Neuronal Activity: From Single Neurons to Networks." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37855.

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Abstract (sommario):
Neurons and networks of the brain may use various strategies of computation to provide the neural substrate for sensation, perception, or cognition. To simplify the scenario, two of the most commonly cited neural codes are firing rate and temporal coding, whereby firing rates are typically measured over a longer duration of time (i.e., seconds or minutes), and temporal codes use shorter time windows (i.e., 1 to 100 ms). However, it is possible that neurons may use other strategies. Here, we highlight three methods of computation that neurons, or networks, of the brain may use to encode and/or
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12

Matteoni, Cosetta. "Studies of neuronal nicotinic receptors of autonomic neurons: expression and function." Doctoral thesis, SISSA, 2007. http://hdl.handle.net/20.500.11767/4726.

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Abstract (sommario):
Neuronal nicotin~c receptors (nAChRs) are important membrane proteins to signal intercellular communication in health and disease. Against a large body of data related to brain or muscle nAChRs, there is comparatively less information concerning such receptors on autonomic sensory neurons. The present investigation was focused on characterizing the expression and function of nAChRs in chromaffin cells of the rat adrenal medulla, on exploring how novel synthetic compounds could modulate acutely or clu·onically nAChRs by using SH-SY5Y cells which are tumorderived cells of chromaffin cell
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13

Hoch, Thomas. "Aspects of information processing by individual neurons and populations of neurons." [S.l.] : [s.n.], 2007. http://opus.kobv.de/tuberlin/volltexte/2007/1566.

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14

Gutiérrez, Fernández Sara. "Funció del factor d'elongació eEF1A2 en plasticitat sinàptica." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/565534.

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Abstract (sommario):
La plasticitat sinàptica és la capacitat que té el sistema nerviós de canviar la seva estructura i funcionament al llarg del desenvolupament. En processos d’aprenentatge, es formen noves espines dendrítiques que permetran fer noves sinapsis, aquest procés rep el nom de plasticitat estructural, també s’ha descrit que es produeix un augment en la síntesi local de proteïnes a les espines. Els mRNAs que es transcriuen en el nucli viatgen silenciats en grànuls de mRNAs fins a arribar a les espines on es produeix una traducció local a les sinapsis. Tot i que la majoria dels estudis sobre el control
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15

Amer, Rebecca K. "Hepoxilins and neuronal repair, effects on SCG neurons after in vitro injury." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ54161.pdf.

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16

Moreau, David. "Infrared stimulation of neurons." Thesis, Limoges, 2017. http://www.theses.fr/2017LIMO0050/document.

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Abstract (sommario):
L’exposition aux radiations laser infrarouge peut être utilisée afin de dépolariser des neurones et stimuler l’activité neuronale. Le mécanisme sous-jacent d’une telle stimulation est supposé résulter d’une interaction photothermique. En effet, l’absorption de la radiation infrarouge par le tissu biologique cible, et l’eau qu’il contient, induit une augmentation de température de manière localisée, qui soit influencerait directement les propriétés membranaires de la cellule soit agirait par le biais de l’activation de canaux ioniques thermo-sensibles. Dans la plupart des cas, l’activité électr
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17

Ching, Shim. "Synaptogenesis between identified neurons." Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55449.

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Serotonergic Retzius (R) neurons of the leech Hirudo medicinalis in culture reform inhibitory synapses with pressure sensitive (P) neurons while selectively reducing an extrasynaptic, depolarizing response to serotonin (5-HT) in the P neuron. We have examined if the selection of 5-HT responses is restricted to sites of contact between processes and growth cones of these cells. As measured by intracellular recording at the soma, focal application of 5-HT depolarized uncontacted P cell bodies, neurites and growth cones but not processes contacted by R cells. In patch clamp recordings of the depo
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18

Wills, Sebastian Alexander. "Computation with spiking neurons." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616274.

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19

Kuang, Xutao. "Adaptation in multisensory neurons." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/65419/.

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Abstract (sommario):
The most studied region in the mammalian brain for multisensory integration is the deep superior colliculus (DSC). Neurophysiological experiments have revealed many response properties of DSC neurons, such as cross-modal enhancement (CME) and sub-additive/additive/super-additive op- erational modes. CME occurs when the response of a multisensory neuron to stimulation in one sensory modality is enhanced, often non-linearly, by temporally and spatially coincident stimulation of a second sensory modality. Response enhancement is frequently larger for weaker input stimuli than for stronger stimuli
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20

Boatin, William. "Characterization of neuron models." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-04182005-181732/.

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Thesis (M. S.)--Electrical and Computer Engineering, Georgia Institute of Technology, 2006.<br>Dr. Robert H. Lee, Committee Member ; Dr. Kurt Wiesenfeld, Committee Member ; Dr Robert J. Butera, Committee Member.
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21

Tanaka, Yasuhiro. "Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex." Kyoto University, 2012. http://hdl.handle.net/2433/157432.

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22

Zagmutt, Caroca Sebastián. "Analysis of the in vivo effect of carnitine palmitoyltransferase 1A deletion in AgRP neurons." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671758.

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Abstract (sommario):
Food intake and whole-body energy balance are regulated by the brain through a sophisticated neuronal network located mostly in the hypothalamus. In particular, the hypothalamic arcuate nucleus (ARC) is a fundamental sensor for the hormones and nutrients that inform about the energy state of the organism. The ARC contains two populations of neurons with opposite functions: anorexigenic proopiomelanocortin (POMC)-expressing neurons and orexigenic Agouti-related protein (AgRP)- expressing neurons. Activation of AgRP neurons leads to an increase in food intake and a decrease in energy expenditur
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23

Woolley, David. "The actions of a soft coral derived natural product on neurones." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=24801.

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24

Carvalho, Milena Menezes. "Structural, functional and dynamical properties of a lognormal network of bursting neurons." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-25052017-110738/.

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Abstract (sommario):
In hippocampal CA1 and CA3 regions, various properties of neuronal activity follow skewed, lognormal-like distributions, including average firing rates, rate and magnitude of spike bursts, magnitude of population synchrony, and correlations between pre- and postsynaptic spikes. In recent studies, the lognormal features of hippocampal activities were well replicated by a multi-timescale adaptive threshold (MAT) neuron network of lognormally distributed excitatory-to-excitatory synaptic weights, though it remains unknown whether and how other neuronal and network properties can be replicated in
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25

Raffaelli, Marco. "Le déclin de TRF2 dans l'hippocampe au cours du vieillissement cause une déficience de la mémoire dépendante de ATM." Electronic Thesis or Diss., Université Côte d'Azur, 2024. http://www.theses.fr/2024COAZ6001.

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Abstract (sommario):
Le vieillissement est la cause principale de la grande majorité des pathologies, allant de l'athérosclérose aux tumeurs et à la démence. Il est donc incontestable que l'amélioration de la connaissance de ce phénomène au niveau cellulaire et moléculaire sera d'une valeur inestimable pour le traitement et la prévention d'un large éventail de pathologies humaines. Un facteur bien établi du vieillissement des cellules mitotiques est l'érosion des télomères médiée par la division cellulaire, un processus qui ne se produit pas dans les cellules post mitotiques telles que les neurones. En effet, on n
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26

Jerregård, Helena. "Factors influencing nerve growth in situ and in vitro /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med693s.pdf.

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27

Huynh, Cong Evelyne. "Le rôle émergeant des microtubules dans la physiopathologie des podocytopathies héréditaires." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T028.

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L’étude des formes familiales de syndrome néphrotique (SN) ou de protéinurie glomérulaire avec lésions histologiques de hyalinose segmentaire et focale (HSF) a permis d’incriminer plus d’une vingtaine de gènes, majoritairement exprimés par le podocyte, cellule principale de la barrière de filtration glomérulaire (BFG). Parmi ces gènes, près d’une dizaine code des régulateurs du cytosquelette d’actine démontrant ainsi le rôle central de la plasticité et de l’architecture du podocyte dans le fonctionnement du filtre glomérulaire. L’ensemble de ces travaux a permis de définir une nouvelle catégor
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28

Fedorow, Heidi School of Medical Science UNSW. "Neuromelanin in human dopamine neurons." Awarded by:University of New South Wales. School of Medical Science, 2005. http://handle.unsw.edu.au/1959.4/32717.

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Abstract (sommario):
Neuromelanin (NM) is a dark polymer pigment present in specific populations of catecholaminergic neurons in the brain. Interest in this pigment has rekindled in recent years because of a hypothesised link between NM and the especial vulnerability of NM-containing neurons to cell death in Parkinson???s disease (PD). Many aspects of the biology of NM are yet to be characterised. It is not known if NM like the similar melanin of the skin is synthesised via an enzymatic pathway or solely through autoxidation as has traditionally been thought. Examination of the ultrastructure of NM granules showed
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29

Oliet, Stéphane H. R. "Osmoreception in rat supraoptic neurons." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28874.

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Abstract (sommario):
The osmotic control of neurohypophysial hormone release is mediated by central and peripheral osmoreceptors which perceive changes in fluid osmolality. The mechanism underlying signal transduction in these structures, however, has remained obscure. Supraoptic neurons, which synthesize and secrete the neurohypophysial hormones, are themselves recognized to be osmoreceptors. Combined electrophysiological and micromorphometric measurements were therefore obtained in acutely isolated rat supraoptic neurons to determine the cellular basis for signal transduction in osmoreception. Osmotically-evoked
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30

Johnson, Richard James Ramsay. "Plasticity in adult automatic neurons." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299940.

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31

Qiu, Xiaoliang. "Kiss1 Neurons and Metabolic Sensing." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1373034912.

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32

Starodub, Alexander N. "Ionic channels in intestinal neurons /." The Ohio State University, 2000. http://rave.ohiolink.edu/etdc/view?acc_num=osu1488192119264469.

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33

Yelhekar, Tushar. "Chloride Homeostasis in Central Neurons." Doctoral thesis, Umeå universitet, Institutionen för integrativ medicinsk biologi (IMB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127655.

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The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. Inhibition is, in the adult brain, most often mediated by the neurotransmitter γ-aminobutyric acid (GABA). GABA may, however, in some cases cause excitation. GABA acts by activating GABA type A receptors (GABAARs), which are ion channels largely permeable to Cl–. The effect of
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34

Maimaiti, Shaniya. "INSULIN ACTIONS ON HIPPOCAMPAL NEURONS." UKnowledge, 2017. http://uknowledge.uky.edu/pharmacol_etds/20.

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Abstract (sommario):
Aging is the main risk factor for cognitive decline. The hippocampus, a brain region critical for learning and memory formation, is especially vulnerable to normal and pathological age-related cognitive decline. Dysregulation of both insulin and intracellular Ca2+ signaling appear to coexist and their compromised actions may synergistically contribute to neuronal dysfunction with aging. This dissertation focused on the interaction between insulin, Ca2+ dysregulation, and cognition in hippocampal neurons by examining the contributions of insulin to Ca2+ signaling events that influence memory fo
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35

DE, SANCTIS Claudia. "MicroRNAs profiling in Dopaminergic neurons." Doctoral thesis, Università degli studi del Molise, 2018. http://hdl.handle.net/11695/83499.

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Abstract (sommario):
Lo sviluppo dei neuroni dopaminergici mesencefalici (mDA) è un fenomeno complesso e non ancora pienamente compreso. Molti studi hanno focalizzato la loro attenzione sul ruolo svolto da diversi fattori di trascrizione specifici e ben noti. L'obiettivo della mia tesi di dottorato è focalizzato su una classe relativamente nuova di regolatori post-trascrizionali denominati microRNA (miRNAs), in grado di regolare l'espressione genica legando le sequenze parzialmente complementari nelle regioni 3' non tradotte (UTR) degli mRNAs target. Per studiare il ruolo svolto dai miRNAs durante la differenziaz
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36

Arosio, Daniele. "Imaging Chloride Homeostasis in Neurons." Doctoral thesis, Università degli studi di Trento, 2017. https://hdl.handle.net/11572/368512.

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Intracellular chloride and pH are fundamental regulators of neuronal excitability and they are often co-modulated during excitation-inhibition activity. The study of their homeostasis requires simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering and two-photon-imaging this thesis work led to the discovery of new chloride-sensitive GFP mutants and to the establishment of ratiometric imaging procedures for the quantitative combined imaging of intraneuronal pH and chloride. These achievements have been demonstrated in vivo in the mouse
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37

Arosio, Daniele. "Imaging Chloride Homeostasis in Neurons." Doctoral thesis, University of Trento, 2017. http://eprints-phd.biblio.unitn.it/1937/2/DECLARATORIA_ENG_signed.pdf.

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Abstract (sommario):
Intracellular chloride and pH are fundamental regulators of neuronal excitability and they are often co-modulated during excitation-inhibition activity. The study of their homeostasis requires simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering and two-photon-imaging this thesis work led to the discovery of new chloride-sensitive GFP mutants and to the establishment of ratiometric imaging procedures for the quantitative combined imaging of intraneuronal pH and chloride. These achievements have been demonstrated in vivo in the mouse
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38

Erasmus, Louwrence Daniel. "The formulation and evaluation of a neuron model based on biological neurons / Louwrence Daniël Erasmus." Thesis, North-West University, 2007. http://hdl.handle.net/10394/2307.

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Abstract (sommario):
This thesis formulates and evaluates a mathematical model from an engineer's point of view based on the currently-known information-processing processes and structures of biological neurons. The specification and evaluation of the RealNeuron model form a baseline for current use in engineering solutions and future developments. The RealNeuron is a carefully-reduced model that retains the essential features of more complex models. A systems engineering approach is used to formulate it, i.e. the model is described as using multiple resolution levels with configurable modular elements at each re
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39

Mahoney, Sally-Ann. "A role for tissue transglutaminase in neuron / glial interaction and development of cerebellar granule neurons." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361111.

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40

Adams, Van L. "Seasonal plasticity of A15 dopaminergic neurons in the ewe." Morgantown, W. Va. : [West Virginia University Libraries], 2001. http://etd.wvu.edu/templates/showETD.cfm?recnum=2096.

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Abstract (sommario):
Thesis (M.S.)--West Virginia University, 2001.<br>Title from document title page. Document formatted into pages; contains vii, 79 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 70-78).
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41

Vázquez, de la Torre Cervera Aurelio. "Estudio de la apoptosis inducida por la inhibición de la vía de la PI3K/AKT." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/110926.

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Abstract (sommario):
Una de las vías que se postula que tienen una mayor importancia en las enfermedades neurodegenerativas es la de los inositoles fosfato. Para el estudio de esta vía se ha utilizado un inhibidor farmacológico de la fosfoinositol 3 cinasa (PI3K), el LY294002, en un modelo in vitro de células granulares de cerebelo de rata (CGC). Al tratar las CGC con una dosis de 30μM de LY294002 se produce una muerte celular por apoptosis que es independiente de calpaínas y dependiente de caspasas, además no se observa la fragmentación de p35 ni de α espectrina que se da por activación de las calpaínas. Los ensa
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42

Tang, Ping. "Simulation du traitement effectué par certaines cellules étoilées du noyau cochléaire antéroventral et analyse de leur comportement en terme de modulation d'amplitude /." Thèse, Chicoutimi : Université du Québec à Chicoutimi, 1995. http://theses.uqac.ca.

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43

Teller, Amado Sara. "Functional organization and networ resilience in self-organizing clustered neuronal cultures." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396114.

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Abstract (sommario):
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological properties of the brain's circuits. To deepen in the understanding of the activity-connectivity relationship, neuronal cultures have emerged as remarkable systems given their accessibility and easy manipulation. A particularly appealing configuration of these in vitro systems consists in an assembly of interconnected aggregates of neurons termed 'clustered neuronal network
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44

Creyssels, Sophie. "Comprendre les mécanismes cellulaires déficients dans la MPS VII par l'utilisation de neurones humains dérivés d'iPSC." Thesis, Montpellier, 2015. http://www.theses.fr/2015MONTT009.

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Abstract (sommario):
Les processus moléculaires mis en jeu lors de maladies de surcharge lysosomale (MSL) et qui conduisent à des dysfonctions neuronales sont peu connus. Afin de mieux comprendre comment s’opèrent ces dysfonctions neuronales associées à la mucopolysaccharidose de type VII (MPS VII), une MSL causée par la déficience en l’activité enzymatique de la ß-glucuronidase, nous avons généré des neurones humains MPS VII à partir cellules souches pluripotentes induites (iPSC). Grâce à la reprogrammation des fibroblastes de patients MPS VII, nous avons généré et caractérisé des neuroprécurseurs dérivés d’iPSC
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45

Nesbit, Matthew. "The development of an identified neuronal population within rat visual cortex : callosal projection neurons." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361816.

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46

Petersson, Marcus. "Dendritic and axonal ion channels supporting neuronal integration : From pyramidal neurons to peripheral nociceptors." Doctoral thesis, KTH, Beräkningsbiologi, CB, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-102362.

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Abstract (sommario):
The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. In the field of neuroscience we are not only curious about how our brains work, but also strive to characterize and develop treatments for neural disorders, in which the neuronal harmony is distorted. By modulating ion channel activity (pharmacologically or otherwise) it might be possible to effectively restore neur
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47

Jayakar, Selwyn S. "Abl family kinases regulate neuronal nicotinic receptors and synapses in chick ciliary ganglion neurons." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1242668863.

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Abstract (sommario):
Dissertation (Ph.D.)--University of Toledo, 2009.<br>"In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences." Title from title page of PDF document. Bibliography: p. 138-150.
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48

GIANSANTE, GIORGIA. "The paroxysmal disorder gene PRRT2 downregulates NaV channels and neuronal excitability in human neurons." Doctoral thesis, Università degli studi di Genova, 2018. http://hdl.handle.net/11567/929007.

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Abstract (sommario):
Proline-Rich Transmembrane Protein 2 (PRRT2) has been identified as the single causative gene for a group of paroxysmal syndromes, including benign familial infantile seizures, paroxysmal kinesigenic dyskinesia and migraine. Most of the mutations of this gene lead to a premature stop codon, generating an unstable form of mRNA or a truncated protein that is degraded, pointing out the loss of the PRRT2 function as pathogenic mechanism of action. In this thesis, we have used different approaches to investigate the pathophysiological function of PRRT2. An important role for PRRT2 in the neurotrans
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49

Javalet, Charlotte. "Rôle des exosomes comme nouvelle voie de communication entre les neurones." Thesis, Université Grenoble Alpes (ComUE), 2016. http://www.theses.fr/2016GREAV028/document.

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Abstract (sommario):
Les exosomes sont des vésicules d’origine endosomale sécrétées par les cellules dans leur environnement après fusion à la membrane plasmique des endosomes multivésiculés. Les exosomes représentent un nouveau mode de communication entre les cellules en permettant un transfert direct de protéines, de lipides et d’ARN. L’objectif de ma thèse était d’étudier le rôle des exosomes dans la communication entre les neurones. Précédemment, le laboratoire a montré que les neurones sécrètent des exosomes de manière régulée par l’activité synaptique. Nous avons observé que les exosomes neuronaux ne sont en
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50

Fame, Ryan Marie. "Molecular Controls over Developmental Acquisition of Diverse Callosal Projection Neuron Subtype Identities." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10591.

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Abstract (sommario):
The mammalian neocortex is an exquisite, highly organized brain structure composed of hundreds of subpopulations of neurons and glia, precisely connected to enable motor control, sensory perception, information integration, and planning. Unique molecular, structural, and anatomical neuronal properties underlie diverse functionality, endowing much of the neocortex’s complex processing power. Neocortical size correlates with information processing capacity, suggesting that increased neuronal number and diversity begets increased sophistication. One excitatory projection neuron type, callosal pro
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