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Tesi sul tema "Novel marker"

Autore: Grafiati

Pubblicato: 14 marzo 2023

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1

Kon, Samantha Swee Chin. "Habitual gait speed : a novel prognostic marker in COPD?" Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/56925.

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Forced expiatory volume in one second (FEV1) is the most widely accepted marker in COPD. However, COPD is now well recognised as a multisystem and heterogeneous disease, and it is unlikely that a single marker could reflect the complex range of observed pathophysiologic changes. Exercise intolerance is a common symptom in COPD, and reflects both lung and skeletal muscle dysfunction. Logistical issues often mean physical performance is not routinely measured objectively in all clinical settings. Gait speed is an easy, quick to perform established measure of physical performance in the elderly,

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2

Holtkötter, Hannah [Verfasser]. "Novel marker systems for forensic body fluid identification / Hannah Holtkötter." Ulm : Universität Ulm, 2018. http://d-nb.info/1166756602/34.

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3

Gahunia, Harpal Kaur. "A novel cartilage biochemical marker (CM-1), isolation, purification and characterization." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0020/NQ45732.pdf.

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4

Juhász, Margit Lai Wun. "Murine CD248 and its cytoplasmic domain : characterising a novel tumour and inflammation marker." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42573.

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Abstract (sommario):

CD248 is a member of a family of transmembrane glycoproteins containing an N-terminal C-type lectin-like domain. This family includes thrombomodulin and CD93, proteins known to modulate immunity, cell proliferation and homeostasis. CD248 is expressed in perivascular and stromal cells, during embryonic development and post-natally during inflammation and cancer. In the mesenchymal compartment of most normal adult tissues, CD248 expression is not detectable. It is believed that CD248 is involved in cross-talk between endothelial cells and pericytes, thereby playing a role in growth, metastasis a

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5

Лобода, Андрій Миколайович, Андрей Николаевич Лобода, Andrii Mykolaiovych Loboda, and M. Tutuola. "Cystatin C - A novel marker of kinder injury in the newborns with asphyxia." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32303.

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In clinical practice, kidney injury is detected when serum creatinine concentrations increase over a short period of time, with or without oliguria. To assess renal function in neonates is used determination of glomerular filtration rate (GFR) after creatinine. But creatinine concentration is not a decisive marker. Changes in serum creatinine may be influenced by other factors, which are not directly related to kidney damage, such as age, sex, body mass and nutritional status. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32303

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6

Akarca, Ayse. "Immunohistochemical studies for identification of biomarkers in haematological malignancies: An approach for potential novel therapeutic targets." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1127626.

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Lymphoid neoplasms are a subgroup of haematological malignancies that affect circulating lymphocytes. The clinical and biological heterogeneity of lymphoid neoplasms can lead to difficulty in accurate diagnosis in this group of diseases. The advancement in effective and feasible detection platforms has enabled novel biomarkers to improve diagnosis and prognosis, in addition to assist in patient stratification and personalised treatments for these diseases. Although there have been improvements in high-throughput diagnostic techniques, the conventional immunohistochemistry (IHC) remains the mos

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7

Traore, Karim. "Characterization of novel rice germplasm from West Africa and genetic marker associations with rice cooking quality." Texas A&M University, 2005. http://hdl.handle.net/1969.1/4146.

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Genetic resource enhancement is the foundation of any good breeding program. Landraces from West Africa, interspecifics between Oryza sativa and Oryza glaberrima and improved lines from the West African Rice Development Association and other research centers were introduced to the Beaumont Rice Research center for in situ evaluation and characterization. Beside the introduction of seeds, milled samples were also introduced for grain chemistry analysis. Field evaluation combined with physicochemical and molecular characterization revealed unique characteristics among African germplasm. New rice

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8

Gasca, Stéphan Emmanuel. "Cordon-bleu, a novel murine developmental marker gene isolated by a gene trap approach." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0020/NQ27650.pdf.

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9

Limb, Marie. "MUC1 mucin as a tumour marker : investigations into a novel immunoassay and reagent development." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395584.

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10

Rolan, Paul Edward. "The exploratory clinical development of tucaresol, an antisickling agent, using a novel surrogate marker /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09M.D/09m.dr744.pdf.

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Thesis (M.D.)--University of Adelaide, Dept of Clinical and Experimental Pharmacology, 1995.<br>Copies of author's previously published articles inserted. Describes the exploratory clinical development of tucaresol, consisting of three studies performed on humans and subsequent in vitro and animal studies investigating the possible effects on the immune system. Demostrates that rational drug design may be an efficient way of selecting potential therapeutic candidates.

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11

Aladowicz, E. "RALP, A NOVEL PROGNOSTIC MOLECULAR MARKER IN MELANOMA, IS INVOLVED IN THE NOTCH PATHWAY." Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155518.

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Abstract (sommario):

Melanoma is an aggressive disease with high metastatic potential and resistance to cytotoxic agents. Early-stage melanomas can be successfully cured by surgery and, as in all solid tumours, morbidity and mortality of melanoma are a consequence of local invasion and metastatic spread. The molecular mechanisms involved in the progression of the malignancy, the genetic markers associated to metastatic melanoma dissemination and the acquisition of chemoresistance are only beginning to be defined. An understanding of the molecular biology of melanoma provides a necessary basis to enable the generat

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12

Konieczny, Marek [Verfasser], and Marco [Akademischer Betreuer] Düring. "Clinical application of novel marker for cerebral small vessel disease / Marek Konieczny ; Betreuer: Marco Düring." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2021. http://d-nb.info/1229835636/34.

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13

Dräger, Carolin [Verfasser]. "Safety and efficacy of a novel live marker vaccine against Classical swine fever virus / Carolin Dräger." Greifswald : Universitätsbibliothek Greifswald, 2017. http://d-nb.info/1124411291/34.

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14

Losito, O. F. "Doing without antibiotics : the pMB1 origin of replication as a novel selectable marker in enteric bacteria." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1384826/.

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Abstract (sommario):

Plasmids are used in the biopharmaceutical industry for the production of recombinant proteins, recombinant DNA for DNA vaccines and as non-viral vectors for gene therapy. Antibiotic- resistance genes are used for plasmid selection and to ensure plasmid maintenance. Regulatory bodies like the European Medicines Agency have introduced guidelines to limit the use of antibiotics and their resistance genes in the manufacture of therapeutics. Therefore, it is important to develop novel, effective methods for antibiotic-free plasmid selection. Cobra Biologics has designed a novel mechanism for antib

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15

Smit, Corneli. "Pyramiding of novel rust resistance genes in wheat, utilizing marker assisted selection and doubled haploid technology." Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85613.

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Thesis (MSc)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Wheat rust, caused by the Puccinia spp., is a global biotic cause of wheat yield losses. This disease can effectively be combatted by implementing rust resistant wheat cultivars. The release of new resistant wheat cultivars is however prolonged due to the time needed to fix resistance genes in a good quality background and develop pure breeding wheat lines. The aim of this study was the pyramiding of novel species derived leaf and stripe rust resistance genes in bread wheat lines through the utilization of high throughput marker

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16

Shyshynova, Inna. "A Novel Approach to Identification of Diagnositc Markers in Prostate Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1152729787.

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17

Konishi, Sayuri. "A transmembrane glycoprotein,gp38,is a novel marker for immature hepatic progenitor cells in fetal mouse livers." Kyoto University, 2011. http://hdl.handle.net/2433/147338.

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18

Scivoletto, Salvatore. "A novel marker for heart failure: Cross sectional area assessment in a large vein by conductance catheter." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8513/.

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Abstract (sommario):

The present study investigates the feasibility of a new application able to check the heart failure status in a patient through the estimation of the venous distension. In this way it would be possible to follow up patients, avoiding invasive or expensive exams such as cardiac catheterization and echocardiography. Moreover, the devices would also be able to diagnose the decline of the disease, in order to allow a new adaptation to therapy, and vice versa to check the improvement in the patient’s conditions after the CRT device implant. This thesis is essentially divided into three parts: an a

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19

Hochschartner, Gerald. "Revealing the past : the potential of a novel small nucleolar RNA (snoRNA) marker system for studying plant evolution." Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/1695.

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Abstract (sommario):

Despite the existence of various molecular marker systems there are still limitations in distinguishing between closely related species based on molecular divergence, especially when hybridization events have occurred in the past. The characterisation of plant small nucleolar RNA (snoRNA) genes and their organisation into multigene clusters provides a potential nuclear marker system which could help in resolving the phylogenetic history of plants and might be applicable in DNA barcoding. Using closely and distantly related Senecio species, I investigated a combination of fragment length and se

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20

Lambert, Carol-Ann. "A novel marker technique : using miniature inverted-repeat transposable elements (MITEs) in combination with resistant gene analogues (RGAs)." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52117.

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Thesis (PhD)--Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Given the organisation of the maize genome as well as demands placed on the saturation of molecular linkage maps it would be desirable to identify informative molecular markers that is located or linked to genic rich areas. Sequences of gene products from different gene classes were investigated. Proteins containing a nucleotide binding site (NBS) and leucine-rich repeat (LRR) region comprise the largest class of disease resistance proteins. Resistant gene analogue (RGA) primers belonging to this specific class were derive

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21

Noudomi, Seishiro. "CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor." Kyoto University, 2016. http://hdl.handle.net/2433/217140.

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22

Fu, Peng [Verfasser], and Jörg-Christian [Akademischer Betreuer] Tonn. "Membrane Hsp70 expression in gliomas : a novel, hypoxia-related marker for primary glioblastoma / Peng Fu. Betreuer: Jörg-Christian Tonn." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027949266/34.

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23

Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135252.

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Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched

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24

Miller, Aaron Christopher. "Clostridium difficile infection as a novel marker for hospital quality, efficiency and other factors associated with prolonged inpatient length of stay." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1884.

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Excess inpatient length of stay (LOS) varies between hospitals and is burdensome to patients and the overall healthcare system. Variation in LOS has often been associated with hospital-level factors, such as hospital efficiency and quality. Clostridium difficile infection (CDI) is an increasingly common hospital-acquired (HA) infection. This thesis explores the connection between hospital incidence of CDI and excess LOS in patients without a CDI. It is hypothesized that HA-CDI incidence may act as a "proxy variable" to capture unobserved hospital characteristics, such as hospital quality or ef

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25

Wang, Chao. "Microfluidics for particle manipulation : new simulation techniques for novel devices and applications." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:8125980e-0603-4425-b0fa-89a4fdfdf464.

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This thesis focuses on fundamental aspects of microfluidic systems and applies relevant findings to innovative designs for advanced particle manipulation applications. Computational Fluid Dynamics (CFD) is adopted for fluid modeling, based on the Finite Volume method. The accuracy of the solutions obtained is confirmed by grid sensitivity analysis and by comparisons with experimental work. Curved microchannel features and the induced Dean flow are studied through a parametric space exploration and simulations. The Lagrange-Euler coupling method – Surface Marker Point methodology – is applied t

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26

Liu, Wen [Verfasser]. "Stem cell marker expression of canine neoplasia generated cell subpopulations and effect of novel arylindolylmaleimides on canine lymphoma cell lines / Wen Liu." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2015. http://d-nb.info/1080825509/34.

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27

Mousavinasab, F. (Firoozeh). "Effects of lifestyle and genetic factors on the levels of serum adiponectin, a novel marker of the metabolic syndrome, in Finnish servicemen." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285042.

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Abstract Metabolic syndrome (MetS) is a combination of disorders that increase one's risk for type 2 diabetes (DM2) and cardiovascular disease (CVD). Both lifestyle and genetic factors have been established to be involved in the aetiology of MetS. Improving our knowledge about the pathophysiology of MetS could provide more effective therapeutic approaches and reduce the risk of developing DM2 and CVD. Lower levels of adiponectin, an adipose-derived protein, has been shown to be associated with the components of MetS. Common variants in a number of candidate genes related to MetS have been show

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28

Cui, Tiantian [Verfasser], Iver [Akademischer Betreuer] Petersen, Peter F. [Akademischer Betreuer] Zipfel, and Sven [Akademischer Betreuer] Perner. "Human complement factor H is a novel diagnostic marker for lung adenocarcinoma / Tiantian Cui. Gutachter: Iver Petersen ; Peter F. Zipfel ; Sven Perner." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2012. http://d-nb.info/1019125055/34.

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29

Nyström, Hanna. "Stromal collagens in colorectal cancer and in colorectal liver metastases : tumour biological implications and a source for novel tumour markers." Doctoral thesis, Umeå universitet, Kirurgi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-67860.

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Abstract (sommario):

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality. About 50 % of patients with CRC will develop subsequent liver metastases (CLM). The survival for untreated CLM is only a few months and liver resection provides the only chance for a lasting cure. It is therefore essential to detect CLM early, enabling successful surgical resection and achieving a long-term cure. There are no optimal tumour markers for CRC or CLM. The best marker available is Carcinoembryonic Antigen (CEA), a marker found elevated in about 50-60% of patients with CLM, but also in

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30

Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Karger, 1999. https://tud.qucosa.de/id/qucosa%3A27632.

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Abstract (sommario):

Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched

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31

Öhlund, Daniel. "Basement membrane collagens in pancreatic cancer : novel stroma-derived tumor markers and regulators of cancer cell growth." Doctoral thesis, Umeå universitet, Kirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37555.

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Background: Among the common malignancies, pancreatic cancer has the shortest long-term survival. The aggressive, rapid, and infiltrative growth pattern of pancreatic cancer, together with the lack of specific symptoms, often leads to late diagnosis. Metastases are frequently found at the time of diagnosis, which prevents curative surgical treatment. Good tumor markers would enable early detection, thus improving the prognosis. Unfortunately, no such markers are available in the clinic. The tumor stroma is defined as the non-malignant cells and the extracellular matrix (ECM) of a cancer. Pancr

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32

Knappe, Nathalie [Verfasser], and Viktor [Akademischer Betreuer] Umansky. "Partial reprogramming of melanoma cells mimics the phenotype switch and reveals SNAI3 as a novel invasion-associated marker / Nathalie Knappe ; Betreuer: Viktor Umansky." Heidelberg : Universitätsbibliothek Heidelberg, 2015. http://d-nb.info/1180396308/34.

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33

Liu, Chia-Hao [Verfasser], and Michael [Akademischer Betreuer] Lanzer. "Linkage analysis identifies an ubiquitin transferase gene as a novel marker for reduced quinine and quinidine responsiveness in Plasmodium falciparum / Chia-Hao Liu ; Akademischer Betreuer: Michael Lanzer." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1180068084/34.

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34

Liu, Yueyang [Verfasser], Viktor [Akademischer Betreuer] Magdolen, Birgit [Gutachter] Luber, and Viktor [Gutachter] Magdolen. "Kallikrein-related peptidase 10: a novel independent prognostic marker in advanced high-grade serous ovarian cancer and triple-negative breast cancer / Yueyang Liu ; Gutachter: Birgit Luber, Viktor Magdolen ; Betreuer: Viktor Magdolen." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1183910061/34.

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35

Jeffery, Penelope Lorrelle. "An Investigation into the role of the ghrelin axis in hormone-dependent cancer and characterisation of a novel Exon 3-deleted preproghrelin isoform and its murine homologue." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16260/1/Penelope_Jeffrey_Thesis.pdf.

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Ghrelin is a 28 amino acid peptide hormone with a unique octanoic acid modification that has an extensive range of physiological effects, including stimulation of growth hormone (GH) release, appetite regulation, and modulation of reproductive functions. The cognate receptor for ghrelin is the growth hormone secretagogue receptor (GHS-R), a G protein-coupled receptor with two documented isoforms, the functional GHS-R type 1a and the C-terminally truncated GHS-R type 1b. Several ghrelin variants have also been identified in addition to the n-octanoylated form of ghrelin. In our laboratory, we h

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36

Corbett, Christopher. "Novel markers of liver fibrosis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5603/.

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With chronic liver disease rising, the need to stage of liver disease and fibrosis accurately is paramount as it helps guide therapy and informs prognosis. Liver biopsy is a flawed gold standard, associated with morbidity and mortality. Application of simple non-invasive tests to assess fibrosis could provide a safe way of identifying patients in greatest need of intervention and of monitoring response to therapy. I have shown in this thesis that transient elastography is an excellent tool for ruling out significant fibrosis in patients with chronic liver disease. It is easy to learn and succe

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37

Smyth, Rosemary. "Investigation of novel urinary markers of hepatotoxicity." Thesis, University College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417145.

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38

Welsh, Paul. "Inflammatory markers as novel predictors of cardiovascular disease." Connect to e-thesis, 2008. http://theses.gla.ac.uk/86/.

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Abstract (sommario):

Thesis (Ph.D.) - University of Glasgow, 2008.<br>Ph.D. thesis submitted to the Division of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, 2008. Includes bibliographical references. Print version also available.

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Welsh, Paul I. "Inflammatory markers as novel predictors of cardiovascular disease." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/86/.

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Inflammation is widely considered to be an important contributing factor in atherogenesis and the risk of atherothrombotic complications. Baseline measurements of some inflammatory markers are known to be predictive risk factors for future cardiovascular disease (CVD) events in prospective epidemiological studies. Inflammatory markers dominant in the literature are acute phase response (APR)-associated and include fibrinogen, C-reactive protein (CRP) and, more recently, interleukin- (IL-) 6. This thesis reviews the literature and suggests the need for further research into novel inflammatory m

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Isohookana, J. (Joel). "Emerging novel prognostic markers in pancreatic ductal adenocarcinoma." Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526220352.

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Abstract (sommario):

Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, the 5-year survival rate being less than 5%. At the time of diagnosis, 90% of PDACs extend beyond the pancreas and distant metastases are often present. Due to aggressive growth, local expansion and early appearance of metastasis, primary PDAC tumours are local enough for curative surgical resection in only 10–20% of the cases. Adjuvant chemotherapy is indicated in these curative-treated cases, with slight improvement in survival. PDAC is considered to represent a heterogeneous group of biologically and pro

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Varghese, Robin. "Novel Prognostic Markers and Therapeutic Targets for Glioblastoma." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71420.

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Abstract (sommario):

Glioblastoma is the most common and lethal malignant brain tumor with a survival rate of 14.6 months and a tumor recurrence rate of ninety percent. Two key causes for glioblastomas grim outcome derive from the lack of applicable prognostic markers and effective therapeutic targets. By employing a loss of function RNAi screen in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were investigated to find prognostic markers as well as therapeutic targets for glioblastoma. Ana

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42

James, Samantha. "Herpèsvirus de primates et de chauves-souris du nouveau monde : modèles d'étude des relations évolutives hôtes-virus DNA polymerase sequences of New World Monkey Cytomegaloviruses : another molecular marker with which to infer Platyrrhini systematics Novel herpesviruses of neotropical bats and their relationships with other members of the Herpesviridae family." Thesis, Guyane, 2019. http://www.theses.fr/2019YANE0004.

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Les virus appartenant à la famille Herpesviridae (ordre Herpesvirales) sont répartis au sein de trois sous-familles : Alpha-, Beta- et Gamma-herpesvirinae. Ils ont été identifiés à partir d’un large spectre d’espèces hôtes, allant des mammifères aux reptiles en passant par les oiseaux et ont la capacité de persister toute au long de la vie de l’hôte. La plupart de ces virus sont par ailleurs spécifiques d’une espèce hôte. La large distribution des herpèsvirus, associée à une infection généralement asymptomatique chez l’hôte naturel suggèrent que ces virus auraient co-évolué avec leurs hôtes.Mo

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Dhiman, Paula. "Incorporating novel risk markers into established risk prediction models." Thesis, University of Nottingham, 2015. http://eprints.nottingham.ac.uk/30666/.

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Introduction: Risk prediction models are used as part of formal risk assessment for disease and health events in UK primary care. To improve the accuracy of risk prediction, new risk factors are being added to established risk prediction models. However, current methods used to evaluate the added value of these new risk factors have shown to be limited. These limitations can be addressed using health economic methodology, but is yet to be used to evaluate and compare risk prediction models by means of their effectiveness and cost. Methods: A cost effectiveness analysis was performed using a de

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O'Malley, James. "Novel cell surface markers identify routes to iPS cells." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/8883.

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Abstract (sommario):

The generation of induced pluripotent stem cells (iPSCs) presents a challenge to normal developmental processes. The low efficiency and heterogeneity of most methods have hindered understanding of the precise molecular mechanisms promoting, and roadblocks preventing, efficient reprogramming. While several intermediate populations have been described, it has proved difficult to characterize the rare, asynchronous transition from these intermediate stages to iPSCs. The rapid expansion of a minor population of reprogrammed cells can also obscure investigation of relevant processes. Understanding

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Poli, Maurizio. "Novel molecular markers for assessment of human embryo competence." Thesis, University of Oxford, 2016. http://ora.ox.ac.uk/objects/uuid:4c5bffff-d12c-4df1-b5f0-1459298fc45c.

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Abstract (sommario):

In vitro fertilization treatments are responsible for 1-5&percnt; births in industrialized countries. The safest way to generate a pregnancy is to transfer a single embryo to the mother, reducing the likelihood of multiple gestations. Hence, in order to maximize the chance of success, it is extremely important that the embryo prioritised for transfer is the most capable within the cohort of embryos generated by the patient. Along with cytogenetic components, it has been suggested that embryo protein expression patterns may correlate with its ability to implant. However, embryo proteomics strat

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46

Lee, Wai Suet. "Discovery of Novel Markers of Virus Transmission by Mosquitoes." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390018.

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Abstract (sommario):

Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Current vector control strategies have been impeded by mosquitoes acquiring resistance to insecticide. Therefore, development of new vector control strategies is urgently needed to complement current strategies. In this thesis, efforts have focused on characterizing the glycan-lectin interactions of Ross River virus (RRV; Togaviridae: Alphavirus) with their mosquito vectors. RRV is the most common arbovirus in Australia that causes clinical manifestations including arthralgia and myalgia

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47

NAKO, ALBANA. "A novel sentiment measure and the stock market return." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2014. http://hdl.handle.net/2108/202697.

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Abstract (sommario):

The main issue in finance nowadays is to understand the financial market dynamics. This paper attempts to shed light on the relationship between media sentiment and stock market returns. An enormous amount of data are analyzed to define media sentiment. The data are downloaded from Twitter accounts of the main relevant economic financial journals and blogs at present in Italy. After classifying each message in positive, negative and neutral through natural linguistic processing, the investor sentiment index is defined and the VAR model is adopted. The paper demonstrates sentiment index derived

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48

Lee, Tsz-hang Jimmy, and 李子恆. "Characterization of novel lipocalin LCN14 expressed in mouse." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193542.

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Abstract (sommario):

Obesity is one of the leading causes of world-wide life-threatening diseases, such as type 2 diabetes mellitus, atherosclerosis and cardiovascular diseases. So far, there is no effective, promising and safe remedy. Development of cost-effective anti-obesity therapies and promising biomarkers for obesity-related diseases have become a demanding task. Lipocalins, such as LCN13, were recently identified as potential drug target because of its beneficial effects on glucose and fat metabolism in mouse. LCN14 is a putative lipocalin that share high degree of homology with LCN13. In this study, it is

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49

Garcia, Michael R. "Identification of novel nuclear markers for use in phylogenetic analysis." Tallahassee, Fla. : Florida State University, 2010. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/2181925.

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Abstract (sommario):

Thesis (Honors paper)--Florida State University, 2010.<br>Advisor: Dr. Gavin J.P. Naylor, Florida State University, College of Arts and Sciences, Dept. of Biology. Includes bibliographical references.

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50

Bin, Kaderi Mohamed Arifin. "Assessment of Novel Molecular Prognostic Markers in Chronic Lymphocytic Leukemia." Doctoral thesis, Uppsala universitet, Hematologi och immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-110371.

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Abstract (sommario):

The clinical course of chronic lymphocytic leukemia (CLL) is highly heterogeneous, which has prompted the search for biomarkers that can predict prognosis in this disease. The IGHV gene mutation status and certain genomic aberrations have been identified as reliable prognostic markers of clinical outcome for this disorder. However, the search for more feasible prognostic markers in CLL is still being pursued. Recently, certain single nucleotide polymorphisms (SNPs) in the GNAS1, BCL2 and MDM2 genes and the RNA expression levels of the LPL, ZAP70, TCL1, CLLU1 and MCL1 genes were suggested as no

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