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Letteratura scientifica selezionata sul tema "OAT15A"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 15 febbraio 2022

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Articoli di riviste sul tema "OAT15A"

Zhang, Yufei, Pu Yang, Runze Li e Haixin Chen. "Unsteady Simulation of Transonic Buffet of a Supercritical Airfoil with Shock Control Bump". Aerospace 8, n. 8 (26 luglio 2021): 203. http://dx.doi.org/10.3390/aerospace8080203.

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The unsteady flow characteristics of a supercritical OAT15A airfoil with a shock control bump were numerically studied by a wall-modeled large eddy simulation. The numerical method was first validated by the buffet and nonbuffet cases of the baseline OAT15A airfoil. Both the pressure coefficient and velocity fluctuation coincided well with the experimental data. Then, four different shock control bumps were numerically tested. A bump of height h/c = 0.008 and location xB/c = 0.55 demonstrated a good buffet control effect. The lift-to-drag ratio of the buffet case was increased by 5.9%, and the root mean square of the lift coefficient fluctuation was decreased by 67.6%. Detailed time-averaged flow quantities and instantaneous flow fields were analyzed to demonstrate the flow phenomenon of the shock control bumps. The results demonstrate that an appropriate “λ” shockwave pattern caused by the bump is important for the flow control effect.

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Huang, JingBo, ZhiXiang Xiao, Jian Liu e Song Fu. "Simulation of shock wave buffet and its suppression on an OAT15A supercritical airfoil by IDDES". Science China Physics, Mechanics and Astronomy 55, n. 2 (11 gennaio 2012): 260–71. http://dx.doi.org/10.1007/s11433-011-4601-9.

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Accorinti, Alessandro, Tim Baur, Sven Scharnowski, Johannes Knebusch, Johannes Dillinger, Yves Govers, Jens Nitzsche e Christian J. Kahler. "Measurements of deformation, schlieren and forces on an OAT15A airfoil at pre-buffet and buffet conditions". IOP Conference Series: Materials Science and Engineering 1024, n. 1 (1 gennaio 2021): 012052. http://dx.doi.org/10.1088/1757-899x/1024/1/012052.

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Geoghegan, Jack A., Nicholas F. Giannelis e Gareth A. Vio. "A Numerical Investigation of the Geometric Parametrisation of Shock Control Bumps for Transonic Shock Oscillation Control". Fluids 5, n. 2 (10 aprile 2020): 46. http://dx.doi.org/10.3390/fluids5020046.

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At transonic flight conditions, shock oscillations on wing surfaces are known to occur and result in degraded aerodynamic performance and handling qualities. This is a purely flow-driven phenomenon, known as transonic buffet, that causes limit cycle oscillations and may present itself within the operational flight envelope. Hence, there is significant research interest in the development of shock control techniques to either stabilise the unsteady flow or raise the boundary onset. This paper explores the efficacy of dynamically activated contour-based shock control bumps within the buffet envelope of the OAT15A aerofoil on transonic flow control numerically through unsteady Reynolds-averaged Navier–Stokes modelling. A parametric evaluation of the geometric variables that define the Hicks–Henne-derived shock control bump will show that bumps of this type lead to a large design space of applicable shapes for buffet suppression. Assessment of the flow field, local to the deployed shock control bump geometries, reveals that control is achieved through a weakening of the rear shock leg, combined with the formation of dual re-circulatory cells within the separated shear-layer. Within this design space, favourable aerodynamic performance can also be achieved. The off-design performance of two optimal shock control bump configurations is explored over the buffet region for M = 0.73, where the designs demonstrate the ability to suppress shock oscillations deep into the buffet envelope.

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Youngblood, Geri L., e Douglas H. Sweet. "Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney". American Journal of Physiology-Renal Physiology 287, n. 2 (agosto 2004): F236—F244. http://dx.doi.org/10.1152/ajprenal.00012.2004.

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An uncharacterized murine cDNA clone was identified and, through sequence, phylogenetic, and functional analysis, determined to encode the newest member of the organic anion transporter family, organic anion transporter 5 (Oat5; Slc22a19). The Oat5 cDNA clone contained an insert 1,964 bp in length with a predicted open reading frame (from bp 84 to bp 1,739) coding for a peptide 551 amino acids long. Slc22a19 was localized to mouse chromosome 19 near the genes encoding Oat1 ( Slc22a6) and Oat3 ( Slc22a8). Northern blot analysis revealed Oat5 is highly expressed in the kidney of adult mice and rats. No sexual dimorphism in renal or hepatic expression of Oat5 was observed. Unlike Oat1–3, Oat5 expression was not detected in the choroid plexus of either mice or rats. Murine Oat5-expressing Xenopus laevis oocytes supported increased accumulation of the mycotoxin ochratoxin A, compared with water-injected control oocytes. This uptake was significantly inhibited by probenecid and the organic anions 2,4-dichlorophenoxyacetic acid, salicylate, and estrone sulfate but not by para-aminohippurate or urate. Transport of ochratoxin A by murine Oat5 was saturable, with an estimated Km of 2.0 ± 0.45 μM. Oat5-mediated transport was neither cis-inhibited nor trans-stimulated by the dicarboxylate glutarate. Uptake was also completely unaffected by short-circuiting of the membrane potential. Thus the motive forces behind Oat5 function, which provide insight into its membrane localization, need to be further resolved. These data demonstrate for the first time that this newly identified gene encodes a protein that functions as an organic anion transporter.

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Brzica, Hrvoje, Davorka Breljak, Marija Ljubojević, Daniela Balen, Vedran Micek, Naohiko Anzai e Ivan Sabolić. "Optimal Methods of Antigen Retrieval for Organic Anion Transporters in Cryosections of the Rat Kidney". Archives of Industrial Hygiene and Toxicology 60, n. 1 (1 marzo 2009): 7–17. http://dx.doi.org/10.2478/10004-1254-60-2009-1895.

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Optimal Methods of Antigen Retrieval for Organic Anion Transporters in Cryosections of the Rat KidneyTo localise antigens by immunocytochemistry (IC), the samples of tissues or cells are usually denatured by fixation, and either frozen and cryosectioned, or embedded in paraffin before sectioning. p-Formaldehyde (PFA; formalin) is a common fixative, which preserves antigenicity of proteins, but damages the tissue/cell morphology and "masks" the antibody binding sites (epitopes). In order to "unmask" epitopes, some kind of antigen retrieval (AR) is used. The aim of this study was: a) to find an optimal AR method in cryosections of in vivo PFA-fixed kidneys for organic anion transporters (Oat) that reside in the basolateral (Oat1, Oat3) and brush-border membrane (Oat2, Oat5) of the rat renal proximal tubules, and b) using optimal method, to compare IC staining of Oats in kidneys that had been PFA-fixed in vivo or in vitro. IC staining in untreated cryosections was compared with that following detergent treatment or microwave heating in citrate buffer of pH 3, pH 6, or pH 8, with or without alcohol pre-treatment. The preferred AR method for Oat1, Oat2, and Oat5 was heating of cryosections at pH 6, and for Oat3 heating at pH 3, without alcohol pre-treatment. Compared with tissue fixed in vivo, tissue fixed in vitro exhibited damaged tubule morphology, similar staining intensity of Oat1 and Oat3, and higher staining intensity of Oat2 and Oat5. We conclude that for optimal IC presentation, each Oat in the rat kidney has to be treated individually, with different fixation and AR approach.

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Kwabiah, A. B., D. Spaner e A. G. Todd. "Shoot-to-root ratios and root biomass of cool-season feed crops in a boreal Podzolic soil in Newfoundland". Canadian Journal of Soil Science 85, n. 3 (1 agosto 2005): 369–76. http://dx.doi.org/10.4141/s02-032.

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Barley (Hordeum vulgare L.) and oat (Avena sativa L.) crops are grown as feed grains by Newfoundland (NL) dairy farmers. The cereals are either grown as monoculture or intercropped with field pea (Pisum sativum L.) with or without N fertilization. Two experiments were conducted in both 2000 and 2001 to evaluate the shoot-to-root (S:R) weight ratios and root biomass in these production systems. Experiment 1 involved monocultures of pea sown at 150 kg ha-1, and barley and oat each sown at 170 kg ha-1. For pea-barley and pea-oat intercrops, pea was sown at 150 kg ha-1 and each cereal component was sown at either 85 and 170 kg ha-1. The seven treatments were referred to, respectively, as pea150, barley170, oat170, pea150-barley85, pea150-oat85, pea150-barley170, and pea150-oat170. Experiment 2 evaluated factorial combinations of two barley seeding rates of 107 kg ha-1 (low) and 157 kg ha-1 (high) and three N rates (0, 30 and 60 kg ha-1) applied at Zadok’s Growth Stage (ZGS 30). Root biomass was sampled from soil (30-cm depth) and determined at about the anthesis stage of oat and barley and the shoot biomass at maturity (ZGS 90). In exp.1, the S:R ratios of oat170 and pea150-oat85and pea150-oat170 ranged from 8.1 to 8.8 and were lower than barley170, pea150, pea150-barley85and pea150-barley170 which ranged from 10.0 to 12.5. Barley170 had the highest root biomass of 835 kg ha-1 followed by pea150-barley170 (745 kg ha-1) and pea150-oat170 (765 kg ha-1). Intercropping pea with cereals increased root biomas s by 31% for pea150-barley85and 48% for pea150-oat85compared to pea150. However, root biomass increased by 109% for pea150-barley170 and 104% for pea150-oat170, indicating that the cereal component of the intercrops contributed more to the root biomass than the pea at the higher seeding rate of the cereal crop. In exp. 2, the 0 kg N ha-1 rate produced the lowest S:R ratios irrespective of the barley seeding rate. When N was applied, both the shoot biomass and root biomass appeared to be increased at the high barley seeding rate. The feed grain production practice in Newfoundland could affect root biomass production in soil. High cereal seeding rates in either monoculture and intercrop systems are required to maximize root biomass production and therefore increase C inputs into the soil. Key words: Shoot-to-root (S:R) ratios, root biomass, intercrops, barley, oat, pea, seeding rate

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Olszewski-Hamilton, U., M. Svoboda, T. Thalhammer, V. Buxhofer-Ausch, K. Geissler e G. Hamilton. "Organic Anion Transporting Polypeptide 5A1 (OATP5A1) in Small Cell Lung Cancer (SCLC) Cells: Possible Involvement in Chemoresistance to Satraplatin". Biomarkers in Cancer 3 (gennaio 2011): BIC.S7151. http://dx.doi.org/10.4137/bic.s7151.

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Background The role of organic anion transporting polypeptide 5A1 (OATP5A1) a member of a family of drug transporters that mediate cellular uptake of drugs has not been characterized so far. Methods Gene expression levels of OATP5A1 in small cell lung cancer (SCLC) cell lines were determined by real-time qPCR and chemosensitivity of HEK-293- SLCO5A1-transfected cells to satraplatin in MTT assays. Results Significant expression of this transporter was found at the mRNA level, primarily in drug-resistant SCLC cells, and SLCO5A1-transfected HEK-293 cells showed higher resistance to satraplatin. OATP5A1 is found preferentially in cytoplasmic membranes of tumor cells, including SCLC. Conclusions OATP5A1 seems to effect intracellular transport of drugs and may participate in chemoresistance of SCLC by sequestration, rather than mediating cellular uptake. Since satraplatin failed to improve survival in SCLC patients, the relation of OATP5A1 expression to clinical drug resistance and its use as marker of chemoresistance should be further investigated.

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Wu, Wei, Michael E. Baker, Satish A. Eraly, Kevin T. Bush e Sanjay K. Nigam. "Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members". Physiological Genomics 38, n. 2 (luglio 2009): 116–24. http://dx.doi.org/10.1152/physiolgenomics.90309.2008.

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When the organic anion transporter Oat1 was first identified as NKT (Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier DR, Nigam SK. J Biol Chem 272: 6471–6478, 1997), it was argued that it, together with Oct1, may be part of a larger subfamily (now known as SLC22) involved in organic ion and xenobiotic transport. The least studied among SLC22 transporters are the so-called unknown substrate transporters ( USTs). Here, five novel genes located in a cluster on mouse chromosome 19, immediately between Slc22a8 ( Oat3)/ Slc22a6 ( Oat1) and Slc22a19 ( Oat5), were identified as homologs of human USTs. These genes display preferential expression in liver and kidney, and one gene, AB056422, has several splicing variants with differential tissue expression and embryonic expression. Along with Slc22a6, Slc22a8, and Slc22a19, these Usts define the largest known cluster of mammalian Slc22 genes. Given the established functions of Oats, these genes may also be involved in organic anion transport. Usts have characteristic motifs and share a signature residue in the possible active site of transmembrane domain 7, a conserved, positively charged, amino acid, Arg356, possibly a site for interaction with organic anions. In certain species, Oat1 and Oat3 appeared to be highly conserved, whereas the Ust part of this cluster appeared to undergo repeated species-specific amplification, suggesting strong environmental selection pressure, and perhaps providing an explanation for copy number variation in the human locus. One Ust amplification in mouse appears to be recent. This cluster may be coordinately regulated and under selective pressure in a species-specific manner.

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Durmus, Selvi, Jyoti Naik, Levi Buil, Els Wagenaar, Olaf van Tellingen e Alfred H. Schinkel. "In vivodisposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters". International Journal of Cancer 135, n. 7 (4 marzo 2014): 1700–1710. http://dx.doi.org/10.1002/ijc.28797.

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Più fonti

Tesi sul tema "OAT15A"

Beck, Paulo Arthur. "Análise metodológica de simulações de escoamentos turbulentos sobre seções de perfis aerodinâmicos". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/28925.

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Este trabalho apresenta o resultado da aplicação do Método dos Volumes Finitos, adotado pelo software comercial Star-CCM+ na simulação para o regime permanente de escoamentos turbulentos incompressíveis e compressíveis sobre seções de aerofólios. Para o caso incompressível modelam-se seções do aerofólio NACA 0012 com ângulo de ataque zero. Para o caso compressível, uma seção do aerofólio supercrítico OAT15A em pequeno ângulo de ataque é modelada. Os domínios computacionais são discretizados por malhas não estruturadas de células poliédricas ou por malhas estruturadas de geração hiperbólica para diferentes topologias e parâmetros construtivos determinados pela estimativa de grandezas do fenômeno físico, como a altura da primeira camada de células quadrilaterais junto à parede. A qualidade e adequação dessas malhas para as simulações são verificadas por estudo de dependência quanto ao nível de refinamento e também quanto à posição do contorno onde o escoamento é livre no caso de escoamento compressível. Na metodologia de verificação, o índice de convergência de malha GCI e a ordem observada de convergência do método (dos Volumes Finitos) são obtidos para três níveis de refinamento com o propósito de selecionar uma malha de trabalho que concilie precisão e esforço computacional com os recursos disponíveis. As simulações são conduzidas para dois modelos de turbulência – o modelo Spalart-Allmaras e o modelo k-ω/SST. Os resultados obtidos pela aplicação desses modelos são interpretados sob o ponto de vista fenomenológico e comparados com os resultados experimentais disponíveis em literatura.
The Finite Volumes Method adopted by the commercial software Star-CCM+ is applied to the simulation of the steady state regime of incompressible and compressible turbulent flows over selected airfoil’s sections. The physical model used with the incompressible flow case is a NACA 0012 airfoil section at zero angle of attack. The ONERA’s OAT15A supercritical airfoil section at small angle of attack applies to the compressible flow case. The computational domains are discretized by structured and unstructured meshes for different topologies and far field configurations. The structured meshes are of the quadrilateral type with hyperbolic node distribution whilst the unstructured meshes use polyhedral cells. The grids are generated by applying a methodology where estimates of the flow variables are used as input for the grid’s constructive parameters like the near wall cell thickness. Grid dependency studies are carried out in order to verify the grid’s quality and suitability to represent the physical phenomena. The grid’s asymptotic convergence index GCI and its observed order of convergence are evaluated for three refinement levels and far field position for the compressible flow cases. The objective is to select the most suitable grid taking into account the accuracy requirements and the computational resources available. The one-equation Spalart-Allmaras turbulence model and the two-equation k-ω/SST turbulence models are used. The numerical results are discussed from the physical point of view and compared with the experimental ones available in literature.

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Koons, Rachel. "Discrepancy of Organic Richness within the Oatka Creek and Union Springs of the Marcellus Formation". Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1543276713273698.

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Braun, Christina [Verfasser]. "Expressionsregulation der organischen Anionentransporter OAT1 und OAT3 im Ischämie-Reperfusions-Modell / Christina Braun". Halle, 2018. http://d-nb.info/116913274X/34.

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Sebastian, Katrin [Verfasser]. "Sensibilization of dendritic cell-like antigen-presenting cells by low-molecular weight drugs : molecular characterization and function of the dendritic cell-specific organic anion transporting polypeptide OATP5A1 / Katrin Sebastian". Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2013. http://d-nb.info/1033988634/34.

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Schulz, Kei [Verfasser], BIRGITTA-CHRISTINA [Akademischer Betreuer] BURCKHARDT, BIRGITTA-CHRISTINA [Gutachter] BURCKHARDT e Oliver [Gutachter] Gross. "Untersuchung der Transportvorgänge des Prolyl-Hydroxylase-Hemmers ICA an den Transportern OAT1, OAT2, OAT3 und OAT4 von proximalen Nierentubuluszellen / Kei Schulz ; Gutachter: Birgitta-Christina Burckhardt, Oliver Gross ; Betreuer: Birgitta-Christina Burckhardt". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2017. http://d-nb.info/1149958529/34.

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Wegner, Waja. "Transcriptional regulation of sex-dependently expressed renal organic anion transporter 1 and 3". Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000D-FB39-A.

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Organische-Anionen-Transporter (OATs) sind maßgeblich an der Ausscheidung von körpereigenen und körperfremden Substanzen über die Niere beteiligt. In Ratten, einem häufig verwendeten Tiermodell in präklinischen Studien, ist bekannt, dass die basolateral lokalisierten Organischen-Anionen-Transporter 1 (Oat1) und 3 (Oat3) in männlichen Tieren stärker und darüber hinaus Testosteron abhängig exprimiert werden. Beide Transporter sind an der Ausscheidung von organischen Anionen, einschließlich negativ geladener Medikamente wie zum Beispiel Adefovir, Furosemid oder Penicillin, beteiligt. In den menschlichen Nieren zählen der OAT1 und der OAT3 zu den klinisch relevanten Transportern, deren Funktionen im Laufe neuer Medikamentenentwicklung berücksichtigt werden sollten. Für das Antibiotikum Penicillin wurde bei Frauen ein vermehrtes Auftreten von Nebenwirkungen im Vergleich zu Männern gezeigt. Dieses erhöhte Risiko könnte möglicher Weise auf einer geschlechtsabhängigen Expression des OAT1 und OAT3 zurückzuführen sein. Ziel der vorliegenden Arbeit war es, den molekularen Mechanismus, der für die höhere Oat1 und Oat3 Expression in den männlichen Rattennieren verantwortlich ist, zu identifizieren. Mit Hilfe von Luciferase assays wurde die Aktivierung von Ratten und menschlichen Oat1/OAT1 und Oat3/OAT3 Promotoren untersucht. Hierzu wurden zunächst Oat1/OAT1 und Oat3/OAT3 Promotorkonstrukte generiert, welche unterschiedlich lange Promotorregionen enthielten, und diese anschließend transient in OK oder LLC-PK1 Zellen transfiziert. Mittels Co-Transfektion potentieller transkriptioneller Regulatoren konnte deren Einfluss auf die Promotoraktivität von Oat1/OAT1 und Oat3/OAT3 untersucht werden. Zur Identifikation geschlechtsabhängig exprimierter Gene in der proximalen Tubuluszelle der Rattennieren wurden von vier männlichen und vier weiblichen Tieren je eine Niere präpariert und deren RNA mit Hilfe eines microarrays und real-time PCR analysiert. Im Rahmen dieser Arbeit konnte gezeigt werden, dass die bereits bekannte männlich dominierende Expression von Oat1 und Oat3 in Rattennieren nicht durch den klassischen Testosteron/Androgenrezeptor vermittelten, transkriptionellen Mechanismus reguliert wird. Vergleichbar zu den Ratten Oat1 und Oat3, zeigten auch die menschlichen OAT1 und OAT3 Promotoren keine Aktivierung durch den Testosteron/Androgenrezeptor-Komplex. Während der Suche nach geschlechtsabhängig exprimierter transkriptioneller Regulatoren in der Rattenniere, konnte die Expression des Transkriptionsfaktors B-cell CLL/ lymphoma 6 (BCL6) erstmalig als männlich dominierend identifiziert werden. Die bereits bekannten Aktivatoren der Oats/OATs Expression, hepatocyte nuclear factor 1α (HNF1α), HNF1β und HNF4α zeigten keine geschlechtsabhängige Expression. Zudem konnte gezeigt werden, dass BCL6 die Promotoren der Ratten und menschlichen Oat1/OAT1 und Oat3/OAT3 aktiviert. Die BCL6-vermittelte Aktivierung von Oat1/OAT1 und Oat3/OAT3 erfolgt nicht über die bislang vorhergesagten BCL6-Bindungsstellen, aber möglicher Weise über Protein-Protein Interaktionen mit den Transkriptionsfaktoren HNF1 oder cAMP response element binding protein (CREB). Zusammenfassend konnte gezeigt werden, dass der Transkriptionsfaktor BCL6 einen vielversprechenden Regulator der geschlechtsabhängigen Expression von Oat1 und Oat3 in Ratten darstellt. Es ist anzunehmen, dass BCL6 ebenso die humane OAT1 und OAT3 Expression reguliert.

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Lin, Chang-Ching, e 林長青. "Study of functional modulation effect of frequently used Chinese herbal medicine on organic anion transporter 1 (OAT1)". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/68290616873155415831.

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碩士
國防醫學院
藥學研究所
97
Herb-drug interaction and Chinese hebal medicine induced nephrotoxicity (CHN) raise great concern since the broad use of Chinese herbal medicine (CHM) in Taiwan. Human ortholog organic anion transporter 1 (hOAT1) located in the kidney basolateral membrane is reported to play an important role in drug-drug interaction and drug induced nephrotoxicty. Therefore, the purpose of this study is to estimate the functional modulation effect of CHM on hOAT1 and to evaluate the possibility of the candidates induced herb-drug interaction and CHN. hOAT1 transfected Madin-Darby canine kidney type II (MDCK II-hOAT1) cell line and original MDCK II cell line were used to complete the in vitro CHM screening and cytotoxicity test. The potential candidates were selected to further in vivo renal functional study, which was performed by continuous infusion of p-aminohippuric acid (PAH) and inulin mixture to Wistar rat. CHM induced kidney injury was then evaluated by kidney biopsy. The results of in vitro screening showed that seven Chinese herbal formulae (Gui-Zhi-Fu-Ling-Wan, Liu-Wei-Di-Huang-Wan, Chia-Wei-Hsiao-Yao-San, Chi-Chu-Di-Huang-Wan, Chih-Po-Di-Huang-Wan, Hsin-I-Ching-Fei-Tang and Lung-Tang-Hsieh-Kan-Tang; by inhibition order) effectively inhibited more than 50% of hOAT1 mediated transport; where two single herbs (Huang-Chin and Huang-Lian; by inhibition order) achieved 30 – 50% inhibition. All of the above mentioned CHM showed concentration-dependent manner of hOAT1 inhibition ability, which revealed that dosage might be related to the effect of CHM on renal function. In the cytotoxicity test, Huang-Chin and Huang-Lian dramatically reduced cell viability of MDCK II-hOAT1 and MDCK II cells, respectively. The reason of the opposite cytotoxicity results in Huang-Chin and Huang-Lian remained unclear and need to be evaluated by further study. In order to estimate the effect of potential CHM candidates on aminal renal function, performed by evaluating PAH and inulin clearance in Wistar rat, a novel analytical method that could simultaneously determine PAH and inulin in rat plasma by LC-MS/MS was developed and well validated. The analytical method was applied to the in vivo study. The results of the in vivo study showed that Gui-Zhi-Fu-Ling-Wan and Chia-Wei-Hsiao-Yao-San significantly decreased PAH secretion clearance (PAHsec) (1.89 ± 0.16/1.96 ± 0.09; control: 2.34 ± 0.05 mL/min/100 mg BW); where Chi-Chu-Di-Huang-Huang, Hsin-I-Ching-Fei-Tang and Lung-Tan-Hsieh-Kan-Tang significantly reduced glomerular filtration rate (GFR) (0.88 ± 0.04/0.80 ± 0.03/0.83 ± 0.04; control: 0.99 ± 0.03 mL/min/100 mg BW). High dose of Gui-Zhi-Fu-Ling-Wan and Lung-Tan-Hsieh-Kan-Tang resulted a more obivious suppression of PAHsec (1.79 ± 0.10/1.76 ± 0.14 mL/min/100 mg BW) rather than GFR (0.92 ± 0.03/0.82 ± 0.05 mL/min/100 mg BW). Biopsy of these two high dose CHM groups showed severe tubular damage. In conclusion, Gui-Zhi-Fu-Ling-Wan, Chia-Wei-Hsiao-Yao-San, Chi-Chu-Di-Huang-Huang, Hsin-I-Ching-Fei-Tang and Lung-Tan-Hsieh-Kan-Tang might be related to herb-drug interaction and CHN.

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Schulz, Kei. "Untersuchung der Transportvorgänge des Prolyl-Hydroxylase-Hemmers ICA an den Transportern OAT1, OAT2, OAT3 und OAT4 von proximalen Nierentubuluszellen". Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F4A-3.

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Kaufhold, Marcel. "Interaktion der Organische-Anionen-Transporter 1 und 3 mit Dicarboxylaten". Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-000E-00F9-D.

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Organische Anionen werden aus dem Blut in die proximalen Tubuluszellen durch Organische-Anionen-Transporter 1 und 3 (OAT1 und OAT3) aufgenommen. Die Aufnahme erfolgt im Austausch gegen Dicarboxylate. In dieser Dissertation wurde die Affinität von Dicarboxylaten gegenüber humanen OAT1 und OAT3 untersucht mit dem Ziel mehr Informationen über die Struktur der Transporter zu erhalten. Es sollten Unterschiede zwischen dem OAT1 und OAT3 ermittelt werden, besonders bezüglich deren Substratspezifität. Alle Transporter wurden stabil in HEK293-Zellen exprimiert. Extrazellulär wurden Dicarboxylate als Inhibitoren gegen die 3H-p-Aminohippurat-Aufnahme (OAT1) oder 3H-Östronsulfat-Aufnahme (OAT3) zugefügt. OAT1 zeigt die höchste Affinität gegenüber Glutarat (IC50 3,3 µM), α-Ketoglutarat (IC50 4,7 µM) und Adipat (IC50 6,2 µM), gefolgt von Pimelat (IC50 18,6 µM) und Suberat (IC50 19,3 µM). Die Affinität von OAT1 gegenüber Succinat und Fumarat war gering. Der OAT3 zeigte dieselbe Dicarboxylat-Selektivität mit etwa 13-mal höheren IC50-Werten verglichen mit dem OAT1. Die Daten charakterisieren α-Ketoglutarat als hochaffines Substrat für den OAT1 und den OAT3. Die Ergebnisse deuten auf eine ähnliche Molekülstruktur der Bindungsstellen von OAT1 und OAT3 hin.

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Henjakovic, Maja PD Dr. "Geschlechtsabhängige Expression renaler und hepatischer Transporter für organische Anionen und Kationen". 2016. http://hdl.handle.net/11858/00-1735-0000-002E-E386-E.

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Capitoli di libri sul tema "OAT15A"

Tirona, Rommel G. "OATP1A2, OAT1, and OAT3". In Pharmacogenomics of Human Drug Transporters, 125–39. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118353240.ch6.

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Wang, Ying, e Nicole Behler. "In Vitro Characterization of Renal Transporters OAT1, OAT3, and OCT2". In Methods in Pharmacology and Toxicology, 417–29. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-742-6_24.

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"OAT1". In Encyclopedia of Signaling Molecules, 3643. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102652.

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Hagos, Yohannes, e Gerhard Burckhardt. "OAT1, Organic Anion Transporter 1". In xPharm: The Comprehensive Pharmacology Reference, 1–4. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.60456-8.

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Atti di convegni sul tema "OAT15A"

Pazner, Will, Michael Franco e Per-Olof Persson. "High-order wall-resolved large eddy simulation of transonic buffet on the OAT15A airfoil". In AIAA Scitech 2019 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2019. http://dx.doi.org/10.2514/6.2019-1152.

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Huang, Jingbo, Zhixiang Xiao, J. Liu e Song Fu. "Numerical Investigation of Shock Buffet on an OAT15A Airfoil and Control Effects of Vortex Generators". In 50th AIAA Aerospace Sciences Meeting including the New Horizons Forum and Aerospace Exposition. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2012. http://dx.doi.org/10.2514/6.2012-44.

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Nguyen, Cuong, Sebastien Terrana e Jaime Peraire. "Wall-resolved implicit large eddy simulation of transonic buffet over the OAT15A airfoil using a discontinuous Galerkin method". In AIAA Scitech 2020 Forum. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2020. http://dx.doi.org/10.2514/6.2020-2062.

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Hu, Shuiying, Navjotsingh Pabla, Laura J. Janke, Lie Li, Aksana Vasilyeva, Jason A. Sprowl e Alex Sparreboom. "Abstract 5471: Identification of OAT1/OAT3 as contributors to cisplatin nephrotoxicity". In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5471.

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Over, D. Jeffrey, Vincent Farruggia, Joseph Ruggiero e Robert D'Andrea. "CONODONTS IN THE MARCELLUS SHALE SUBGROUP (MIDDLE DEVONIAN) IN WESTERN NEW YORK STATE AND MAGNETIC SUSCEPTIBILITY CORRELATION OF CONODONT-POOR STRATA IN THE OATKA CREEK FORMATION". In GSA Annual Meeting in Phoenix, Arizona, USA - 2019. Geological Society of America, 2019. http://dx.doi.org/10.1130/abs/2019am-340672.

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Oh, D. S., H. J. Shin, S. H. Lee e S. M. Oh. "AB1023 Enhanced renal transporter activities of oat1 and oat3 by keishibukuryogan (K-06) and in vivo uric acid modulating effect at potassium oxonate-induced mouse setting". In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.4369.

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