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Articoli di riviste sul tema "Osteoporosis Tibia Rats"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 5 febbraio 2022

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1

Dreyer, Chris H., Marina Rasmussen, Rasmus Hestehave Pedersen, Søren Overgaard, and Ming Ding. "Comparisons of Efficacy between Autograft and Allograft on Defect Repair In Vivo in Normal and Osteoporotic Rats." BioMed Research International 2020 (March 4, 2020): 1–9. http://dx.doi.org/10.1155/2020/9358989.

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Introduction. In the field of orthopaedic surgery, the use of osteogenic material in larger defects is essential. Autograft and allograft are both known methods, and autograft is believed to be the best choice. But autograft is associated with additional invasive procedures which can prove difficult in fragile patients and can cause local side effect after bone harvest. For feasible purposes, the use of allograft is hereby rising and comparing efficacies, and the differences between autograft and allograft are essential for the clinical outcome for the patients. Method. 24 female Norwegian bro

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2

Shi, Na, Chu-Qiong Zhang, Long Han, and Gang Ouyang. "Effect of Acupoint Catgut Embedding on Intestinal Flora in Rats with Ovariectomized Osteoporosis." Acupuncture & Electro-Therapeutics Research 46, no. 4 (2021): 307–18. http://dx.doi.org/10.3727/036012921x16281724938230.

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Objectives: By observing the effect of acupoint catgut embedding on the intestinal flora of ovariectomized osteoporotic rats, the correlation between the regulation of intestinal flora and the prevention and treatment of osteoporosis was discussed preliminarily. Methods: By observing the effect of acupoint catgut embedding on the intestinal flora of ovariectomized osteoporotic rats, the correlation between the regulation of intestinal flora and the prevention and treatment of osteoporosis was discussed preliminarily. Result: Compared with Group A and Group B, bone mineral density (BMD) of femu

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3

Fang, Wen, Shifang Zhao, Fuming He, Li Liu, and Guoli Yang. "Influence of Simvastatin-Loaded Implants on Osseointegration in an Ovariectomized Animal Model." BioMed Research International 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/831504.

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The success of bone implants in the presence of osteoporosis is limited by lack of osseointegration between the implant and the natural bone. This study applied an electrochemical process to deposit simvastatin-nanohydroxyapatite (HA) coatings on porous implant surfaces and investigated the effects of these simvastatin-HA coatings on implant surfaces in an animal model of osteoporosis. In this study, simvastatin-HA coated implants were inserted into the tibia of osteoporotic rats. After 2, 4, and 12 weeks, tissue was retrieved for histomorphometric evaluation. The results indicated that the si

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4

Zhang, Zhiguo, Jiazi Dong, Meijie Liu, et al. "Therapeutic Effects ofCortex acanthopanacisAqueous Extract on Bone Metabolism of Ovariectomized Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/492627.

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The aim of this study was to evaluate effects of aqueous extract fromCortex acanthopanacis(CAE) on osteoporosis rats induced by ovariectomy (OVX) using aqueous extract fromFolium Epimedii(FEE) as positive control agent. Three-month-old female rats that underwent OVX were treated with CAE. After 12 weeks, bone mineral density (BMD) and indices of bone histomorphometry of tibia were measured. Levels of protein and mRNA expression of osteoprotegerin (OPG) and receptor activator of nuclear factor kappa-B ligand (RANKL) in tibia were evaluated. In addition, the serum concentrations of osteocalcin (

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5

Sun, Bo, Tian Su, Zhibin Meng, and Songjie Tang. "Anhuienoside C Ameliorates Osteoclast Differentiation in Ovariectomy-Induced Osteoporosis by Regulating RANKL/Wnt Signaling Pathways." Current Topics in Nutraceutical Research 20, no. 1 (2020): 51–55. http://dx.doi.org/10.37290/ctnr2641-452x.20:51-55.

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Postmenopausal and ovariectomy-induced osteoporosis is the most common bone disorder. While pharmacotherapy has been valuable in the management of osteoporosis, it has been associated with undesired side effects. Plant bioactives with minimal side effects have been seen as adjunct to classical therapy. Herein, we have evaluated the protective effect of anhuienoside C (AC) in a rat model of ovariectomy-induced osteoporosis. The treatment of osteoporotic rats with AC caused dose-dependent favorable changes in biochemical markers of bone formation and metabolism (osteocalcin, C-telopeptide of typ

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6

Komrakova, Marina, Stephan Sehmisch, Mohammad Tezval, et al. "Impact of 4-methylbenzylidene camphor, daidzein, and estrogen on intact and osteotomized bone in osteopenic rats." Journal of Endocrinology 211, no. 2 (2011): 157–68. http://dx.doi.org/10.1530/joe-11-0096.

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The study investigated the influence of 4-methylbenzylidene camphor (4-MBC), daidzein, and estradiol-17β-benzoate (E2) on either intact or osteotomized cancellous bone in ovariectomized (Ovx) rats. Three-month old Ovx rats were fed with soy-free (SF) diet over 8 weeks; thereafter, bilateral transverse metaphyseal osteotomy of tibia was performed and rats were divided into groups: rats fed with SF diet and SF diet supplemented with 4-MBC (200 mg), daidzein (50 mg), or E2(0.4 mg) per kilogram body weight. After 5 or 10 weeks, computed tomographical, biomechanical, histological, and ashing analys

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7

PASSALI, C., A. PATSAKI, P. LELOVAS, et al. "Red wine polyphenols modulate bone loss in the ovariectomized rat model of postmenopausal osteoporosis." Journal of the Hellenic Veterinary Medical Society 70, no. 2 (2019): 1541. http://dx.doi.org/10.12681/jhvms.20860.

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The aim of this study was to examine the effect of Red Wine Polyphenols (RWPs) extract on bone mineral density (BMD) in the ovariectomized (OVX) rat model. Thirty-five 10-month-old Wistar rats were separated into controls (CTRL), OVX and OVX plus RWPs in their drinking water (dose, 50 mg/kg body weight per day), starting immediately after OVX for 6 months. Βody and uterine weight, BMD of the tibia at baseline, 3 and 6 months post-OVX, and 3-pointing bending of the femur, were examined. Statistical comparison of the total tibia BMD within groups during the study period showed a significant redu

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8

Saul, D., M. Ninkovic, M. Komrakova, et al. "Effect of zileuton on osteoporotic bone and its healing, expression of bone, and brain genes in rats." Journal of Applied Physiology 124, no. 1 (2018): 118–30. http://dx.doi.org/10.1152/japplphysiol.01126.2016.

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Estrogen deficiency and aging are associated with osteoporosis, impaired bone healing, and lower cognitive performance. Close functional and physical connections occur between bone and the central nervous system. An anti-inflammatory drug, zileuton (which is an inhibitor of arachidonate 5-lipoxygenase), is known to have a positive effect on bone tissue repair and brain ischemia. We studied the effect of zileuton on osteopenic bone and its healing and on the genes considered to be crucial for the cross talks between bone and brain. Three-month-old Sprague-Dawley rats were ovariectomized or left

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9

Zhuang, Yongliang, Xiaodong Sun, Bingtong Liu, Hu Hou, and Yun Sun. "Effects of Rambutan Peel (Nepheliumlappaceum) PhenolicExtract on RANKL-Induced Differentiation of RAW264.7 Cells into Osteoclasts and Retinoic Acid-Induced Osteoporosis in Rats." Nutrients 12, no. 4 (2020): 883. http://dx.doi.org/10.3390/nu12040883.

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Previous studies have shown that rambutan peel phenolic (RPP) extract has excellent biological activities due to its abundant phenolic content and profile. In this study, the potential anti-osteoporosis (OP) effects of RPP were evaluated by suppressing receptor activator nuclear factor-kappa B ligand (RANKL)-induced differentiation of RAW264.7 cells into osteoclasts and amelioratingretinoic acid-induced OP in rats. Our results showed that RPP efficiently decreased the formation of tartrate-resistant acid phosphatase (TRAP)-positive cells and reduced total TRAP activity in RAW264.7 cells under

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10

Ham, Ju Ri, Ra-Yeong Choi, Hae-In Lee, and Mi-Kyung Lee. "Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats." Molecules 25, no. 5 (2020): 1177. http://dx.doi.org/10.3390/molecules25051177.

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Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced osteopenia and steatosis have not been reported. This study examined the effects of MTS on alcohol-induced bone loss and steatosis. Rats in the alcohol groups were fed a Liber-DeCarli liquid diet containing 36% of its calories as alcohol. MTS was at 0.005% in their diet, while alendronate (positive control; 500 μg/kg BW/day) was administered ora

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Wresdiyati, Tutik, Alamsah Firdaus, and Made Astawan. "Tempe and Soybean var. Grobogan-Indonesia Increased The Number of Osteoblasts and Osteocytes, Inhibited Osteoclast Damage in The Tibia Bone of Rats." HAYATI Journal of Biosciences 28, no. 2 (2021): 144. http://dx.doi.org/10.4308/hjb.28.2.144.

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Tempe, an Indonesian traditional food, is a product of processed soybeans by fermentation. Both tempe and soybeans contain a variety of nutrients, such as isoflavone, Ca, P, and Mg that are important for bone health. This study aimed to observe the influence of Indonesian var. Grobogan tempe flour and soybean flour on the profile of osteoblasts, osteocytes, and osteoclasts in the tibia bone of rats. The rats were divided into five groups; casein, tempe flour 10%, tempe flour 20%, boiled soybean flour 10%, and boiled soybean flour 20% groups. The treatment was conducted for 90 days. The results

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12

Chen, Guanghua, Xinle Zhang, Han Lin, Guizhi Huang, Yahui Chen, and Liao Cui. "Tanshinol Alleviates Osteoporosis and Myopathy in Glucocorticoid-Treated Rats." Planta Medica 83, no. 16 (2017): 1264–73. http://dx.doi.org/10.1055/s-0043-108761.

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AbstractTanshinol is a major water-soluble active component of Salvia miltiorrhiza. In this study, we aimed to investigate whether tanshinol has potential therapeutic effects against glucocorticoid-induced osteoporosis and glucocorticoid-induced myopathy. Ninety-six female Sprague-Dawley rats were randomly assigned to five groups: a control group, a model group, and three model groups treated with 25 or 50 mg/kg of tanshinol, or calcitriol. All model groups received prednisone acetate for 90 days to induce glucocorticoid-induced osteoporosis. Afterwards, all animals underwent a surgical proced

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13

Alam, Md Rafiqul, Soo Mi Kim, Jong Il Lee, et al. "Effects of Safflower Seed Oil in Osteoporosis Induced-Ovariectomized Rats." American Journal of Chinese Medicine 34, no. 04 (2006): 601–12. http://dx.doi.org/10.1142/s0192415x06004132.

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The effects of Korean Safflower (Carthamus tinctorius L) seed oil (SSO) on osteoporosis induced-ovariectomized rats were investigated. A total of 90 female Sprague-Dawley rats, 4-month-old, weighing 200–230 g were randomly assigned into 3 groups (30 animals/group). The animals in group I were sham operated and those of group II and III were ovariectomized (Ovx). After eight weeks, the animals of group I and II received solvent vehicle daily, whereas those of group III were administered SSO orally (1 ml/kg) daily for 30 days. The changes in the serum levels of insulin-like growth factor-I (IGF-

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14

Iimura, Kaori, Nobuhiro Watanabe, Philip Milliken, et al. "Chronic Electrical Stimulation of the Superior Laryngeal Nerve in the Rat: A Potential Therapeutic Approach for Postmenopausal Osteoporosis." Biomedicines 8, no. 9 (2020): 369. http://dx.doi.org/10.3390/biomedicines8090369.

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Electrical stimulation of myelinated afferent fibers of the superior laryngeal nerve (SLN) facilitates calcitonin secretion from the thyroid gland in anesthetized rats. In this study, we aimed to quantify the electrical SLN stimulation-induced systemic calcitonin release in conscious rats and to then clarify effects of chronic SLN stimulation on bone mineral density (BMD) in a rat ovariectomized disease model of osteoporosis. Cuff electrodes were implanted bilaterally on SLNs and after two weeks recovery were stimulated (0.5 ms, 90 microampere) repetitively at 40 Hz for 8 min. Immunoreactive c

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15

Teófilo, Juliana Mazzonetto, Ana Carolina Bernardes Azevedo, Sérgio Olavo Petenusci, Renata Mazaro, and Teresa Lúcia Lamano-Carvalho. "Comparison between two experimental protocols to promote osteoporosis in the maxilla and proximal tibia of female rats." Pesquisa Odontológica Brasileira 17, no. 4 (2003): 302–6. http://dx.doi.org/10.1590/s1517-74912003000400002.

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The effects of two experimental protocols (ovariectomy associated or not with a low calcium diet) used to promote osteoporosis in the rat maxilla and proximal tibia were compared 5 and 11 weeks after surgery. Female Wistar rats were ovariectomized or sham-operated. Half of the ovariectomized rats were fed a low Ca++ diet (ovx*) and the remaining ovariectomized (ovx) and sham animals received a standard chow. At sacrifice, the proximal metaphysis was excised from the tibia and the molars were extracted from the hemi-maxilla. Dry (60°C overnight) and ash (700°C/14 h) weights were measured and th

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16

Velikiy, M., D. Labudzynskyi, O. Lisakovska, E. Pasichna, and S. Ivonin. "Co-action effect of a new pyrazole-containing bisphosphonates and vitamin D3 in experimental osteoporosis." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 82, no. 3 (2020): 29–35. http://dx.doi.org/10.17721/1728_2748.2020.82.29-35.

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Bisphosphonates remain one of the most effective drugs to treat diseases of the musculoskeletal system. Among a wide range of possible options, the methods of bioinformatic analysis were developed, selected and synthesized analogs of bisphosphonates, the radical of which were selected pyrazole derivatives. The development of new advanced bisphosphonate analogues has broad prospects for medical application. The study is devoted to the investigation of the combined action of synthesized nitrogen-containing bisphosphonates (pyrazole-containing analogues) and vitamin D3 in the correction of minera

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Valente, Fabrício L., Anna Paula B. R. Ferreira, Leonardo D. da Costa, Mário J. Q. Louzada, Joaquin H. Patarroyo, and Marlene I. Vargas. "Effects of chronic mild stress on parameters of bone assessment in adult male and female rats." Pesquisa Veterinária Brasileira 36, suppl 1 (2016): 106–12. http://dx.doi.org/10.1590/s0100-736x2016001300016.

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Abstract: Osteoporosis is a multifactorial disease of high prevalence and has great impact on quality of life, because the effects on bone structure increase the risk of fractures, what may be very debilitating. Based on the observation that patients with depression have lower bone mineral density than healthy individuals, many studies have indicated that stress could be an aggravating factor for bone loss. This study evaluates the effect of a protocol of chronic mild stress (CMS) on parameters of bone assessment in male and female rats. Five 5-monh-old rats of each sex underwent a schedule of

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18

Ganz, Cornelia, W. Xu, G. Holzhüter, W. Götz, B. Vollmar, and Th Gerber. "Comparison of Bone Substitutes in a Tibia Defect Model in Wistar-Rats." Key Engineering Materials 493-494 (October 2011): 732–38. http://dx.doi.org/10.4028/www.scientific.net/kem.493-494.732.

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Various bone graft substitutes were used in clinical practise in the treatment of bone defects after trauma or osteoporosis. Many synthetic biomaterials were developed in recent years primarily based on hydroxyapatite (HA). NanoBone® is a nanocrystalline hydroxyapatite (HA) embedded in a porous matrix of silica (SiO2). The ratio of HA:SiO2 varied between 76:24 (wt%; NanoBone®) and 61:39 (wt%; Nanobone® S). The two bone substitutes NB and NB S and a natural bovine bone substitute Bio-Oss® (BO) were evaluated by means of implantation in the tibia of the rat. The aim of this study was to analyze

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Wong, Sok Kuan, Kok-Yong Chin, and Soelaiman Ima-Nirwana. "The Effects of Tocotrienol on Bone Peptides in a Rat Model of Osteoporosis Induced by Metabolic Syndrome: The Possible Communication between Bone Cells." International Journal of Environmental Research and Public Health 16, no. 18 (2019): 3313. http://dx.doi.org/10.3390/ijerph16183313.

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A positive association between metabolic syndrome (MetS) and osteoporosis has been demonstrated in previous animal studies. The mechanisms of MetS in orchestrating the bone remodelling process have traditionally focused on the interactions between mature osteoblasts and osteoclasts, while the role of osteocytes is unexplored. Our earlier studies demonstrated the bone-promoting effects of tocotrienol using a rat model of osteoporosis induced by MetS. This study aimed to investigate the expression of osteocyte-derived peptides in the bone of rats with MetS-induced osteoporosis treated with tocot

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Kostyshyn, N. M., M. R. Gzhegotskyi, L. P. Kostyshyn, and Yu O. Kulyk. "EFFECT OF BODY VIBRATION ON STRUCTURAL ORGANISATION OF TIBIA NANOCOMPOSITES IN RATS WITH GLUCOCORTICOID-INDUCED OSTEOPOROSIS." Fiziolohichnyĭ zhurnal 67, no. 1 (2021): 29–36. http://dx.doi.org/10.15407/fz67.01.029.

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The aim of the study was to evaluate the effect of nonphysiological whole body vibration (0,3g) on the bone structure and metabolism in rats treated with methylprednisolone (3 mg/ kg/day every other day, 24 weeks). Amount of crystalline component and collagen in the bones was determined by X-ray diffraction method, and the level of calcium by atomic adsorption spectroscopy. Bone metabolism was assessed by determining the concentration of markers - osteocalcinandtartrate-resistant acid phosphatase 5b. Methylprednisolone reduced the content of the mineral component in the tibia (–16.8%) in I gro

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Kostyshyn, Nazar M., Mechyslav R. Gzhegotskyi, Liybov P. Kostyshyn, and Stepan I. Mudry. "Effect of zoledronic acid on bone nanocomposites organization and prevention of bone mineral density loss in ovariectomized rats." Drug Metabolism and Personalized Therapy 36, no. 3 (2021): 239–45. http://dx.doi.org/10.1515/dmpt-2020-0187.

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Abstract Objectives Osteoporosis often occurs in individuals of different age groups, frequently during menopause and after ovariectomy. It increases the risk of pathological fractures almost twice. The aim of our research was to assess bone metabolism, nanocomposite structure of the tibia under conditions of ovariectomy and zoledronic acid treatment. Methods X-ray diffraction has been performed for nanostructure analysis of mineral crystallites and crystal lattice of hydroxyapatite in the tibia samples of ovariectomized rats with additional application of bisphosphonate zoledronic acid (0.025

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Boyar, Handan, Belma Turan, and Feride Severcan. "FTIR Spectroscopic Investigation of Mineral Structure of Streptozotocin Induced Diabetic Rat Femur and Tibia." Spectroscopy 17, no. 2-3 (2003): 627–33. http://dx.doi.org/10.1155/2003/826545.

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Diabetes mellitus (DM) can be accepted as a heterogenous multi organ disorder that can affect various systems of the human body. Disorders include retinopathy, neuropathy, cardiomyopathy, musculoskeletal abnormalities such as diminished bone formation and bone healing retardation. Low bone mineral density is often mentioned as a complication for patients with insulin dependent diabetes mellitus (type I DM). Streptozotocin (STZ) induced diabetic rats are good models for investigation of the complications of insulin dependent diabetes. In the present study, the effects of STZ induced diabetes on

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Jiang, Zhiwen, Zhe Li, Wei Zhang, et al. "Dietary Natural N-Acetyl-d-Glucosamine Prevents Bone Loss in Ovariectomized Rat Model of Postmenopausal Osteoporosis." Molecules 23, no. 9 (2018): 2302. http://dx.doi.org/10.3390/molecules23092302.

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Postmenopausal osteoporosis has seriously affected the life quality of elderly women. A natural polymer, chitin, obtained from shells of crab and shrimp, has been widely used in the biomedical field owing to its nontoxicity, biocompatibility, and biodegradability. In this study, natural N-acetyl-d-glucosamine (NAG) was prepared from liquefied chitin. The protective activities of NAG in postmenopausal osteoporosis were evaluated on Sprague Dawley rats and osteoblast-based models. Results showed that oral administration of NAG boosted trabecular bone volume and trabecular numbers. Additionally,

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Chai, Li-juan, Yue Zhang, Pan-yang Zhang, et al. "The Antiosteoporosis Effects of Zhuanggu Guanjie Pill In Vitro and In Vivo." BioMed Research International 2018 (September 23, 2018): 1–11. http://dx.doi.org/10.1155/2018/9075318.

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We investigated the beneficial effects and underlying mechanisms of Zhuanggu Guanjie (ZGGJ) pill in osteoporosis in vitro and in vivo. Bone marrow macrophages from 4–6-week-old mice were cultured in the presence of macrophage colony-stimulating factor (15 ng/mL) and receptor activator of nuclear factor-κB ligand (30 ng/mL). Osteoclast differentiation was determined by quantification of tartrate-resistant acid phosphatase activity. Gelatin zymography was used to detect the activity of matrix metalloproteinases in osteoclasts. Ovariectomized rats were administered orally with estradiol valerate

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Shirke, Sarika S., Sanket R. Jadhav, and Aarti G. Jagtap. "Methanolic Extract of Cuminum cyminum Inhibits Ovariectomy-Induced Bone Loss in Rats." Experimental Biology and Medicine 233, no. 11 (2008): 1403–10. http://dx.doi.org/10.3181/0803-rm-93.

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Several animal and clinical studies have shown that phytoestrogens, plant-derived estrogenic compounds, can be useful in treating postmenopausal osteoporosis. Phytoestrogens and phytoestrogen-containing plants are currently under active investigation for their role in estrogen-related disorders. The present study deals with anti-osteoporotic evaluation of phytoestrogen-rich plant Cuminum cyminum, commonly known as cumin. Adult Sprague-Dawley rats were bilaterally ovariectomized (OVX) and randomly assigned to 3 groups (10 rats/group). Additional 10 animals were sham operated. OVX and sham contr

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Turner, Russell T., Sutada Lotinun, Theresa E. Hefferan, and Emily Morey-Holton. "Disuse in adult male rats attenuates the bone anabolic response to a therapeutic dose of parathyroid hormone." Journal of Applied Physiology 101, no. 3 (2006): 881–86. http://dx.doi.org/10.1152/japplphysiol.01622.2005.

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Intermittent treatment with parathyroid hormone (PTH) increases bone formation and prevents bone loss in hindlimb-unloaded (HLU) rats. However, the mechanisms of action of PTH are incompletely known. To explore possible interactions between weight bearing and PTH, we treated 6-mo-old weight-bearing and HLU rats with a human therapeutic dose (1 μg·kg−1·day−1) of human PTH(1–34) (hPTH). Cortical and cancellous bone formation was measured in tibia at the diaphysis proximal to the tibia-fibula synostosis and at the proximal metaphysis, respectively. Two weeks of hindlimb unloading resulted in a dr

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Hattori, Satoshi, and Naomi Omi. "The effects of royal jelly protein on bone mineral density and strength in ovariectomized female rats." Physical Activity and Nutrition 25, no. 2 (2021): 33–37. http://dx.doi.org/10.20463/pan.2021.0013.

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[Purpose] Sex hormones deficiency leads to dramatically bone loss in particular postmenopausal women. Royal jelly has anti-osteoporosis effect due to maintain bone volume in that condition. We hypothesized that royal jelly protein (RJP, a latent residue after extracting royal jelly) also prevents bone deficient in ovariectomized (OVX) female rats, the animal model of postmenopausal women. [Methods] Female Sprague-Dawley rats (n = 30, 6 weeks age old) were sham operated (Sham; sham operated group, n = 7), OVX control group (OC, n = 7), OVX with low RJP intake group (ORL, n = 8), and OVX with hi

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Vieira, Ewerton, Marcos Silva, Antonio Maia-Filho, et al. "Effect of Cerium-Containing Hydroxyapatite in Bone Repair in Female Rats with Osteoporosis Induced by Ovariectomy." Minerals 11, no. 4 (2021): 377. http://dx.doi.org/10.3390/min11040377.

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Osteoporosis is a public health problem, with bone loss being the main consequence. Hydroxyapatite (HA) has been largely used as a bioceramic to stimulate bone growth. In our work, a cerium-containing HA (Ce-HA) has been proposed and its effects on the antimicrobial and bone-inducing properties were investigated. The synthesis of the materials occurred by the suspension–precipitation method (SPM). The XRD (X-ray Diffraction) confirmed the crystalline phase, and the Rietveld refinement confirmed the crystallization of HA and Ce-HA in a hexagonal crystal structure in agreement with ICSD n° 26205

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Dong, Xiao-Li, Wen-Xuan Yu, Chun-Mei Li, Li-Ping Zhou, and Man-Sau Wong. "Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects Ovariectomized Hyperlipidemic Rats from Bone Loss." American Journal of Chinese Medicine 48, no. 02 (2020): 463–85. http://dx.doi.org/10.1142/s0192415x2050024x.

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Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2 induced MG63 cells to study its effects and mechanisms on osteoblastogenesis against OS. CXE was th

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Noorafshan, A., M. H. Dabbaghmanesh, N. Tanideh, et al. "Stereological study of the effect of black olive hydroalcoholic extract on osteoporosis in vertebra and tibia in ovariectomized rats." Osteoporosis International 26, no. 9 (2015): 2299–307. http://dx.doi.org/10.1007/s00198-015-3126-x.

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Wattanathorn, Jintanaporn, Cholathip Thipkaew, Wipawee Thukham-mee, Supaporn Muchimapura, Panakaporn Wannanon, and Terdthai Tong-un. "Morinda citrifoliaL. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in anIn VivoExperimental Model of Menopause." Oxidative Medicine and Cellular Longevity 2018 (March 25, 2018): 1–13. http://dx.doi.org/10.1155/2018/1039364.

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Abstract (sommario):

We aimed to determine the protective effects against cerebral ischemia and osteoporosis ofMorinda citrifoliaextract in experimental menopause. The neuroprotective effect was assessed by givingM. citrifolialeaf extract at doses of 2, 10, and 50 mg/kg BW to the bilateral ovariectomized (OVX) rats for 7 days. Then, they were occluded in the right middle cerebral artery (MCAO) for 90 minutes. The neurological score, brain infarction volume, oxidative stress status, and ERK1/2 and eNOS activities were assessed 24 hours later.M. citrifoliaimproved neurological score, brain infarction, and brain oxid

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Wong, Ka-Chun, Kin-Shing Lee, Hon-Kit Luk, et al. "Er-Xian Decoction Exerts Estrogen-Like Osteoprotective EffectsIn VivoandIn Vitro." American Journal of Chinese Medicine 42, no. 02 (2014): 409–26. http://dx.doi.org/10.1142/s0192415x1450027x.

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Abstract (sommario):

Er-xian Decoction (EXD), containing Herba epimedii Maxim (HEP) and Curculigo orchioides Gaertn (XM) as principal drugs, is a traditional Chinese medicine (TCM) formula prescribed for the treatment of postmenopausal osteoporosis. In the present study, the in vivo anti-osteoporosis effects of EXD, HEP and XM on four-month-old ovariectomized (OVX) Sprague–Dawley rats were investigated. Micro-computed tomography analysis showed that EXD could significantly improve the micro-architectural parameters (BMD, BV/TV, Tb.N, Tb.Th, and Tb.Sp) of trabecular bone in the distal femur and proximal tibia in OV

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33

Zheng, Hong Xing, De Jing Chen, Yue Xin Zu, En Zhu Wang, and Shan Shan Qi. "Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation." International Journal of Molecular Sciences 21, no. 15 (2020): 5303. http://dx.doi.org/10.3390/ijms21155303.

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Abstract (sommario):

Chondroitin sulfate (CS) has antioxidative, anti-inflammatory, anti-osteoarthritic and hypoglycemic effects. However, whether it has antidiabetic osteoporosis effects has not been reported. Therefore, in this study, we established a STZ-induced diabetic rat model; CS (500 mg kg−1 d−1) was orally administrated for eight weeks to study its preventive effects on diabetic osteoporosis. The results showed that eight weeks of CS treatment improved the symptoms of diabetes; the CS-treated group has increased body weight, decreased water or food intake, decreased blood glucose, increased bone-mineral

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34

Wanderman, Nathan Robert, Cindy Mallet, Hugo Giambini, et al. "An Ovariectomy-Induced Rabbit Osteoporotic Model: A New Perspective." Asian Spine Journal 12, no. 1 (2018): 12–17. http://dx.doi.org/10.4184/asj.2018.12.1.12.

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Abstract (sommario):

<sec><title>Study Design</title><p>Experimental Animal Model.</p></sec><sec><title>Purpose</title><p>The aim of our study was to validate a pure bilateral ovariectomy (OVX) female New Zealand white rabbit model of postmenopausal osteoporosis utilizing animal-sparing <italic>in vivo</italic> techniques for evaluating bone mineral density (BMD). We also sought to demonstrate that bilateral OVX in female New Zealand white rabbits can produce diminished BMD in the spinal column and simulate osteoporosis, without the need for a

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35

Xiao, Hui-Hui, Xueli Yu, Chen Yang, et al. "Prenylated Isoflavonoids-Rich Extract of Erythrinae Cortex Exerted Bone Protective Effects by Modulating Gut Microbial Compositions and Metabolites in Ovariectomized Rats." Nutrients 13, no. 9 (2021): 2943. http://dx.doi.org/10.3390/nu13092943.

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Abstract (sommario):

Flavonoids, found in a wide variety of foods and plants, are considered to play an important role in the prevention and treatment of osteoporosis. Our previous studies demonstrated that Erythrina cortex extract (EC) rich in prenylated isoflavonoids exerted bone protective effects in ovariectomized (OVX) rats. The present study aimed to investigate the interactions of gut microbiota with the EC extract to explore the underlying mechanisms involved in its beneficial effects on bone. Sprague-Dawley female rats of 3-months-old were ovariectomized and treated with EC extract for 12 weeks. EC extrac

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36

Kostyshyn, N. "Bone mineral density of the rat tibia under modeling of glucocorticoid-induced osteoporosis and the influence of whole body vibration: experimental stud." Bukovinian Medical Herald 25, no. 2(98) (2021): 62–67. http://dx.doi.org/10.24061/2413-0737.xxv.2.98.2021.10.

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Abstract (sommario):

The aim – investigate the effect of whole-body vibration with high-frequency on the mineral density of the tibia of rats treated with glucocorticoids.Material and methods. 54 adult male Wistar rats were randomized to three groups: control, experimental group I - rats treated with methylprednisolone and experimental group II - methylprednisolone with whole-body vibration. Rats of the two experimental groups received methylprednisolone at a dose of 3 mg/kg every other day for 24 weeks. Group II was subjected to a total vertical vibration (50 Hz, with a vibration acceleration of 0.3g) for 30 min

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37

Hwang, Young-Seob, Hyun-Jun Jeon, Sang-Hun Shin, et al. "Effect of low intensity pulsed ultrasound (LIPUS) on bone healing around a titanium implant in the tibia of osteoporosis-induced rats." Journal of the Korean Association of Oral and Maxillofacial Surgeons 37, no. 5 (2011): 386. http://dx.doi.org/10.5125/jkaoms.2011.37.5.386.

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38

Chen, Yuanjin, Rui Bai, Wenhui Chen, Shuanglei Li, and Yunxia Jiang. "Zhuang-Gu-Fang Treats Osteoporosis in Ovariectomized Rats by Increasing the Osteogenesis-Related Factors Leptin, Ghrelin, and PYY." Evidence-Based Complementary and Alternative Medicine 2020 (November 17, 2020): 1–9. http://dx.doi.org/10.1155/2020/8164064.

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Abstract (sommario):

Zhuang-Gu-Fang is a Chinese medicinal compound mixture, which is mainly composed of traditional remedies like the Epimedium Herb, Astragalus, and Eucommia among many others. The study is aimed at investigating the therapeutic effect of Zhuang-Gu-Fang in ovariectomized rats. Fifty six-month-old Wistar rats were randomly selected and divided into 5 groups (n = 10), namely, model group, positive group, low-dose Chinese medicine group, medium-dose group, and high-dose group. Another 10 sham operation Wistar rats were taken as a negative control group. After 3 months of intervention, the bone miner

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39

Hsu, Shan-Ling, Wen-Yi Chou, Chieh-Cheng Hsu, et al. "Shockwave Therapy Modulates the Expression of BMP2 for Prevention of Bone and Cartilage Loss in the Lower Limbs of Postmenopausal Osteoporosis Rat Model." Biomedicines 8, no. 12 (2020): 614. http://dx.doi.org/10.3390/biomedicines8120614.

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Abstract (sommario):

Osteoporosis (OP) causes bone loss and weakness, increasing the risk of bone fracture. In this study, rats were divided into Sham, OP, SW(F) (0.25 mJ/mm2 with 1600 impulses to the left medial femur), and SW(T) (0.25 mJ/mm2 with 1600 impulses to the left medial tibia). The bone strength results following SW(T) were better than SW(F) in the modulus, extension at peak load, handleability, and strain at break. SW(T) had the best prevention for bone loss in both lower limbs of ovariectomized (OVX) rats. The cartilage cellular matrixes of both knees were improved in SW(T) and SW(F) compared to that

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40

Hestehave Pedersen, Rasmus, Marina Rasmussen, Søren Overgaard, and Ming Ding. "Effects of P-15 Peptide Coated Hydroxyapatite on Tibial Defect Repair In Vivo in Normal and Osteoporotic Rats." BioMed Research International 2015 (2015): 1–14. http://dx.doi.org/10.1155/2015/253858.

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Abstract (sommario):

This study assessed the efficacy of anorganic bone mineral coated with P-15 peptide (ABM/P-15) on tibia defect repair longitudinally in both normal and osteoporotic rats in vivo. A paired design was used. 24 Norwegian brown rats were divided into normal and osteoporotic groups. 48 cylindrical defects were created in proximal tibias bilaterally. Defects were filled with ABM/P-15 or left empty. Osteoporotic status was assessed by microarchitectural analysis. Microarchitectural properties of proximal tibial defects were evaluated at 4 time points. 21 days after surgery, tibias were harvested for

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41

Sungkamanee, Sudarat, Jintanaporn Wattanathorn, Supaporn Muchimapura, and Wipawee Thukham-mee. "Antiosteoporotic Effect of Combined Extract ofMorus albaandPolygonum odoratum." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/579305.

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Abstract (sommario):

Due to the limitation of osteoporosis therapy, the alternative therapies from natural sources have been considered. In this study, we aimed to determine the antiosteoporotic effect of the combined extract ofMorus albaandPolygonum odoratumleaves. Ovariectomized rats, weighing 200–220 g, were orally given the combined extract at doses of 5, 150, and 300 mg·kg−1BW for 3 months. At the end of study, blood was collected to determine serum osteocalcin, calcium, and alkaline phosphatase level. In addition, tibia bone was isolated to determine bone oxidative stress markers, cortical bone thickness, an

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42

Xu, Min, Ian M. Dick, Robert Day, Drew Randall, and Richard L. Prince. "Effects of a Herbal Extract on the Bone Density, Strength and Markers of Bone Turnover of Mature Ovariectomized Rats." American Journal of Chinese Medicine 31, no. 01 (2003): 87–101. http://dx.doi.org/10.1142/s0192415x0300076x.

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Abstract (sommario):

For many decades, the Chinese have been using herbal medications to treat bone diseases. To examine effects of an extract of ten medicinal herbs on estrogen deficiency bone loss, ten-month-old female rats were randomly divided into three groups: ovariectomized (OVX), OVX treated with herbs (OVX-M) 4 ml/day by gavage, and OVX treated with estrogen (OVX-E) 10 mg subcutaneously (s.c.) twice per week. The bone mineral density (BMD) of the left femur (fBMD), spine (sBMD) and global body (gBMD) were measured at baseline and at 4, 8 and 12 weeks using a Hologic QDR 2000 dual-energy X-ray densitometer

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43

Asano, Fábio Senishi, Fernando Fonseca de Almeida e. Val, Thiago Teixeira Serafim, Maurício José Falcai, Rodrigo Okubo, and Antônio Carlos Shimano. "HIGH-IMPACT DROP EXERCISE ALTERS MECHANICAL PROPERTIES IN OSTEOPENIC BONE." Revista Brasileira de Medicina do Esporte 23, no. 4 (2017): 304–7. http://dx.doi.org/10.1590/1517-869220172304170466.

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Abstract (sommario):

ABSTRACT Introduction: Osteopenia is a reversible condition and precedes osteoporosis. Physical activity and mechanical loading appear to play an important role in the regulation of bone homeostasis, without the side effects of targeted drug therapy. However, there is controversy as to which type of stimulus promotes more effective adaptations with respect to mechanical properties of bones. Objective: To investigate the effects of high-impact drop training on bone structure after ovariectomy-induced osteopenia in 40 10-week-old female Wistar rats. Methods: Twenty female rats (prevention progra

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44

Sakr, Hussein F., Abdelaziz M. Hussein, Elsayed A. Eid, Ammar Boudaka, and Lashin S. Lashin. "Impact of Dehydroepiandrosterone (DHEA) on Bone Mineral Density and Bone Mineral Content in a Rat Model of Male Hypogonadism." Veterinary Sciences 7, no. 4 (2020): 185. http://dx.doi.org/10.3390/vetsci7040185.

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Abstract (sommario):

Objectives: The present study examined the effect DHEA (dehydroepiandrosterone) on bone mineral content (BMC) and bone mineral density (BMD) and biomarkers of bone remodeling in orchidectomized male rats. Material and Methods: A total of 32 male rats were divided equally into four groups (n = 8): (i) control group (C), (ii) control treated with DHEA (Control + DHEA), (iii) orchidectomized (ORCH) group that underwent bilateral orchidectomy and (iv) orchidectomized (ORCH) rats treated with DHEA (ORCH+DHEA). DHEA treatment started 4 weeks after orchidectomy and continued for 12 weeks. After 12 we

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45

Krause, Matthias, Alexander Hapfelmeier, Klaus Püschel, Miachel Amling, and Karl-Heinz Frosch. "Bone Microarchitecture of the Tibial Plateau in Health and Osteoporosis." Orthopaedic Journal of Sports Medicine 5, no. 4_suppl4 (2017): 2325967117S0014. http://dx.doi.org/10.1177/2325967117s00141.

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Abstract (sommario):

Aims and Objectives: A failure rate of up to 69% of surgically treated tibial plateau fractures in the elderly is attributed among others to the increasing incidence of osteoporosis resulting in renewed immobilization and revision surgery. Hence, ideally implants are fixed in regions with sufficient bone mass. However, data on region-specific structural alterations of the tibial plateau in osteoporosis do not exist. The primary aim of the study was to characterize region-specific changes of the bone structure in patients with osteoporosis compared to skeletally healthy controls. Materials and

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46

Dong, Xiao-Li, Ming Zhao, Kwun-Kit Wong, Chun-Tao Che, and Man-Sau Wong. "Improvement of calcium balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid hormone levels." British Journal of Nutrition 108, no. 1 (2011): 92–101. http://dx.doi.org/10.1017/s0007114511005186.

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Abstract (sommario):

Fructus Ligustri Lucidi (FLL) is a commonly prescribed herb in many kidney-tonifying Traditional Chinese Medicinal formulae for the treatment of osteoporosis. The present study aimed to identify the active fractions in FLL and to characterise its effects on Ca balance, calciotropic hormone levels as well as bone properties in mature female rats fed diets containing different levels of Ca. In the present study, 4-month-old Sprague–Dawley female rats were treated with either FLL ethanol extract (EE), ethyl acetate-soluble fraction of EE (EAF), water-soluble fraction of EE (WF) or their vehicle f

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47

Abdel-Mobdy, Ahmed E., Yasmen E. Abdel-Mobdy, and Hoda B. Mabrok. "Cow milk and its dairy products ameliorate bone toxicity in the Coragen-induced rat model." Open Agriculture 6, no. 1 (2021): 498–510. http://dx.doi.org/10.1515/opag-2021-0033.

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Abstract (sommario):

Abstract Coragen is an insecticide that stimulates calcium release from intracellular stores of muscle cells causing death to sensitive species. The present study aimed to evaluate the bone toxic effect of Coragen and the potential therapeutic effect of cow milk, yogurt, and soft cheese in rats. Toxicity was induced by Coragen administration with different doses of 1/20 or 1/40 LD50 in rats. Groups of rats (n = 6) were treated with either 5 g milk, 5 g yogurt, or 1.5 g cheese. Coragen administration elevated alkaline and acid phosphatases activity and reduced the calcium and phosphorus level i

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48

RAUNER, MARTINA, DANIELA STUPPHANN, MARTIN HAAS, et al. "The HLA-B27 Transgenic Rat, a Model of Spondyloarthritis, Has Decreased Bone Mineral Density and Increased RANKL to Osteoprotegerin mRNA Ratio." Journal of Rheumatology 36, no. 1 (2009): 120–26. http://dx.doi.org/10.3899/jrheum.080475.

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Abstract (sommario):

Objective.Bone metabolism in spondyloarthritis (SpA) is not well elucidated. We investigated alterations in bone in the HLA-B27 transgenic rat, a model of SpA.Methods.Femur, tibia, and lumbar vertebral bodies of disease-prone HLA-B27 transgenic, healthy HLA-B7 transgenic, and nontransgenic control rats were used for bone histomorphometric and dual energy x-ray absorptiometry (DEXA) analysis. Serum levels of type I collagen C-telopeptides (CTX), N-terminal propeptide of type I procollagen (P1NP), and osteocalcin, as well as receptor activator of nuclear factor-κ B ligand (RANKL) and osteoproteg

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49

Huang, Caiqiang, Runguang Li, Changsheng Yang, et al. "PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis." Experimental & Molecular Medicine 53, no. 5 (2021): 894–906. http://dx.doi.org/10.1038/s12276-021-00621-y.

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Abstract (sommario):

AbstractOsteoporosis (OP) is the most common systematic bone disorder among elderly individuals worldwide. Long noncoding RNAs (lncRNAs) are involved in biological processes in various human diseases. It has been previously revealed that PAX8 antisense RNA 1 (PAX8-AS1) is upregulated in OP. However, its molecular mechanism in OP remains unclear. Therefore, we specifically designed this study to determine the specific role of PAX8-AS1 in OP. We first established a rat model of OP and then detected PAX8-AS1 expression in the rats with RT-qPCR. Next, to explore the biological function of PAX8-AS1

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50

Komrakova, Marina, Janek Nagel, Daniel Bernd Hoffmann, Wolfgang Lehmann, Arndt Friedrich Schilling, and Stephan Sehmisch. "Effect of Selective Androgen Receptor Modulator Enobosarm on Bone Healing in a Rat Model for Aged Male Osteoporosis." Calcified Tissue International 107, no. 6 (2020): 593–602. http://dx.doi.org/10.1007/s00223-020-00751-x.

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Abstract (sommario):

Abstract Enobosarm (ostarine, MK-2866, or GTx-024) is a non-steroidal selective androgen receptor modulator. This study evaluated the effect of various regimens of enobosarm (EN) on bone healing in an orchiectomized rat model for aged male osteoporosis and compared it to testosterone (T) treatment. Ninety eight-month-old male Sprague Dawley rats were either orchiectomized (Orx) or left intact (Non-Orx) and divided into groups (n = 15/group): (1) Non-Orx; (2) Orx; (3) Orx+T-th; (4) Orx+EN-th; (5) Orx+T-pr; and (6) Orx+EN-pr. Prophylaxis (Pr) treatments were applied immediately after Orx for up

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