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Tesi sul tema "Ovarian structures"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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1

Escrevente, Cristina. "Protein glycosylation of exosomes from ovarian carcinoma cells: structures and biological roles." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/6864.

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Dissertation presented to obtain the Ph.D. degree in Biology<br>Exosomes are small membrane vesicles that are secreted by several cell types including tumour cells. They are formed intracellularly by an inward budding of the membrane of endosomal compartments which are converted to multivesicular bodies. Exosomes are then released into the extracellular environment after fusion of the multivesicular bodies with the plasma membrane. Upon internalization by other cells they may transfer proteins and RNA among cells. Tumour-derived exosomes can promote angiogenesis, cell proliferation, tum

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2

Pereira, Emílio César Martins. "Detecção sorológica e molecular do herpesvírus bovino 1 em estruturas reprodutivas de fêmeas bovinas." Universidade Federal de Viçosa, 2011. http://locus.ufv.br/handle/123456789/5051.

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Made available in DSpace on 2015-03-26T13:46:55Z (GMT). No. of bitstreams: 1 texto completo.pdf: 518698 bytes, checksum: 9b98b706a52c45c02159a500d2de2177 (MD5) Previous issue date: 2011-02-28<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The aim of this study was to evaluate the serological status of slaughterderived cows for the presence of antibodies against bovine herpesvirus 1 (BoHV-1), viral DNA in ovarian tissue, oocyte, follicular fluid and blood of these animals by polymerase chain reaction (PCR) and correlate it with the serological profile. Serum samples, bloo

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3

Yuan, Fang. "DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/466.

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Lysophosphatidic acid (LPA), a naturally-occurring, simple phospholipid, is present at elevated levels in the blood and ascites of ovarian cancer patients. LPA is a ligand of seven cell surface G protein-coupled receptors. It has been known as an oncogenic growth factor in ovarian cancer and other types of human malignancies. However, the precise biological functions of LPA in ovarian oncogenesis remain to be fully elucidated. Our laboratory is interested in studying the potential role of LPA, as a tumor microenvironment factor, in regulation of cancer cell metabolism. A fundamental change ass

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4

Hadley, Jodie Louise. "Structural and functional studies of ovarian tumour-associated keratan sulphate proteoglycans." Thesis, Lancaster University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268002.

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5

Roberts, Charlotte. "Determining the effect of double-stranded RNA treatment in ovarian cancer." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2399.

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DETERMINING THE EFFECT OF DOUBLE-STRANDED RNA TREATMENT IN OVARIAN CANCER By Charlotte Faye Roberts, B.A. A thesis submitted in partial fulfillment of the requirements for the degree of Masters of Science in Biochemistry at Virginia Commonwealth University.Virginia Commonwealth University, 2011Major Director: Jessica K. Bell, Ph.D.Assistant Professor, Department of Biochemistry & Molecular Biology. Epithelial ovarian cancer is a lethal gynecological malignancy. Due to its asymptomatic nature it is typically detected in the latter metastatic stages. Standard treatment protocol involves surgical

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6

Van, Danielle. "Determining the mechanism of double-stranded RNA-induced cell death in ovarian cancer." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/265.

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Ovarian cancer is the most lethal of all gynecological cancers. Current ovarian cancer drug regimens, including taxanes and platinum-based agents, are susceptible to chemoresistance necessitating the development of novel chemotherapeutics. Within tumors pathogen-derived ligands, such as dsRNA, can activate pattern recognition receptors (PRRs) that are capable of inducing apoptosis. In this dissertation we have found that in ovarian cancer cell lines (DOV-13, SKOV-3, CAOV-3, and OVCAR-3), dsRNA treatment alters cell survival. When treated with dsRNA, ovarian cancer cell lines and patient sample

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7

Dang, David. "LYSOPHOSPHATIDIC ACID IS A MEDIATOR OF INTERLEUKIN-6 PRODUCTION IN OVARIAN CANCER CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1907.

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Lysophosphatidic acid (LPA) is a naturally occurring bioactive lysophospholipid that mediates a broad range of cellular processes such as cell proliferation, survival, migration and invasion. LPA also plays a potential role in human oncogenesis as suggested by elevated expression of its receptors and its producing enzymes in malignant tissues. In the current study, we demonstrated that LPA is a potent mediator of interleukin-6 (IL-6) production in ovarian cancer. IL-6 is a pleiotropic cytokine which is thought to be an important mediator of ovarian cancer development and progression. Here, we

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8

Ketene, Alperen Nurullah. "The AFM Study of Ovarian Cell Structural Mechanics in the Progression of Cancer." Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/32968.

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According to the American Cancer Society, Cancer is the second most common cause of death in the United States, only exceeded by heart disease. Over the past decade, deciphering the complex structure of individual cells and understanding the symptoms of cancer disease has been a highly emphasized research area. The exact cause of Cancer and the genetic heterogeneity that determines the severity of the disease and its response to treatment has been a great challenge. Researchers from the engineering discipline have increasingly made use of recent technological innovations, namely the Atomic For

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9

Kennedy, Alanna Marie. "Reproduction of striped bass Morone saxatilis a structural, biochemical, and functional characterization of atresia /." Connect to this title online, 2002. http://www.lib.ncsu.edu/theses/available/etd-06162002-210408/.

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10

Elshaer, Nashwa Ahmed Ali Mohammed 1986. "Molecular keys in structural evolution of insect ovaries." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/454772.

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The present work aims at establishing the first bases for studying the insect oocyte polarity in a phylogenetically basal species, the cockroach Blattella germanica. Our approach was to choose some genes that have been described as key in the establishment of oocyte polarity in Drosophila melanogaster. Among them we studied, Capicua, a HMG box transcription factor repressor in B. germanica, which is required for the establishment of dorsal-ventral patterning of eggshell and embryo. The epidermal growth factor receptor (EGFR) that is also essential for the polarity establishment in the oocyte.

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11

OYESANYA, REGINA. "MOLECULAR MECHANISMS FOR REGULATION OF GENE EXPRESSION BY LYSOPHOSPHATIDIC ACID IN OVARIAN CARCINOMA CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1689.

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Lysophosphatidic acid (LPA) is a potent bioactive phospholipid mediator that functions through multiple G protein couple receptors (GPCRs). LPA is elevated in ascites of ovarian cancer patients and is involved in growth, survival and metastasis of ovarian cancer cells. Gene promoter analyses revealed that some LPA-target genes share similar sets of binding sites for prominent transcription factors posing the possibility of a general mechanism for activation of their expression by LPA. Detailed investigation of the mechanisms of regulation of cyclooxygenase 2 (Cox-2), a paradigm of LPA-regulate

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12

Wu, Jinhua. "CROSSTALK BETWEEN LYSOPHOSPATIDIC ACID (LPA) AND TRANSFORMING GROWTH FACTOR BETA (TGFβ) IN BREAST AND OVARIAN CANCER CELLS". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/308.

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Lysophosphatidic acid (LPA) and transforming growth factor beta (TGFβ) are platelet-derived intercellular mediators of cell proliferation and motility. LPA is a general growth, survival and motility-stimulating factor in mammalian cells. TGFβ prevents proliferation of normal epithelial cells. However, the growth-inhibitory effect of TGFβ is lost or reduced in most malignant cells. Instead, TGFβ promotes migration and invasion of advanced cancer cells. Since LPA and TGFβ are both present in the blood and tumor microenvironments, we were interested in signal integration and functional outcomes i

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13

Mukherjee, Abir. "ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/391.

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Abstract (sommario):

The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis project I used ovarian and other cancer cells as a model system to examine the hypothesis that LPA present in the tumor microenvironment is a pathophysiological determinant of hyperactive de novo lipoge

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14

Liu, Renyan. "Synergistic growth inhibition and enhancement of cell death by combination of Melanoma Differentiation Associated gene-7 (MDA-7/IL-24) and cisplatin in ovarian cancer cell lines." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/7.

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Ovarian cancer is the most lethal gynecological malignancy among women. The current first-line treatments for ovarian cancer are cisplatin, carboplatin and paclitaxel. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Therefore, the resistance to cisplatin therapy has been a critical hurdle in the management of recurrent ovarian cancer. The mechanisms responsible for cisplatin resistance are not completely understood. In the search for new therapies to overcome/bypass cisplatin resist

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15

Indi, S. S. "Structural studies of in situ, reassembled and extracted microtubules in insect ovaries." Thesis, University of Exeter, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376836.

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16

Woo, Ho-Hyung, Sang C. Lee, Steven J. Gibson, and Setsuko K. Chambers. "Expression of the cytoplasmic nucleolin for post-transcriptional regulation of macrophage colony-stimulating factor mRNA in ovarian and breast cancer cells." ELSEVIER SCIENCE BV, 2017. http://hdl.handle.net/10150/623521.

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The formation of the mRNP complex is a critical component of translational regulation and mRNA decay. Both the 5 ' and 3 ' UTRs of CSF-1 mRNA are involved in post-transcriptional regulation. In CSF-1 mRNA, a small hairpin loop structure is predicted to form at the extreme 5 ' end (2-21 nt) of the 5 ' UTR. Nucleolin binds the hairpin loop structure in the 5 ' UTR of CSF-1 mRNA and enhances translation, while removal of this hairpin loop nucleolin binding element dramatically represses translation. Thus in CSF-1 mRNA, the hairpin loop nucleolin binding element is critical for translational regul

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17

Zanini, Elisa. "Studies of the ovarian tumour suppressor protein OPCML with a view to determining its structure and understanding its role in modulating RTK signalling." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/40079.

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The opioid-binding cell adhesion molecule (OPCML) is a glycosylphosphatidylinositol (GPI) anchored protein that was found to be epigenetically inactivated in 83% of ovarian cancers and demonstrated to act as a tumour suppressor gene (TSG), inhibiting tumour cell growth in vitro and severely attenuating tumourigenesis in vivo (Sellar et al., 2003). We subsequently showed that OPCML exerted its suppressor functions by negatively regulating a spectrum of receptor tyrosine kinases (RTKs), such as ErbB2/HER2, FGFR1 and EphA2, attenuating their downstream signalling (McKie et al., 2012). Initial in

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18

Mansouri, Mahmoud R. "Molecular Characterisation of Structural Chromosomal Abnormalities Associated with Congenital Disorders." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6887.

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19

Marques, Sónia Alexandra Cardoso. "Ovarian structures segmentation using a neural network approach." Master's thesis, 2019. https://hdl.handle.net/10216/121794.

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20

Lopez-Diaz, M. Cruz. "Effects of repeated acute stress on luteinizing hormone binding capacity of ovarian structures in ruminants." 1991. http://catalog.hathitrust.org/api/volumes/oclc/24157572.html.

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21

Lin, Wei-Ting, and 林蔚婷. "Identification of a group of plasma protein structures specifically associated with disease state of ovarian cancer patients." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/72va67.

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碩士<br>國立陽明大學<br>生化暨分子生物研究所<br>100<br>Epithelial ovarian cancer (EOC) in its early does not usually produce symptoms or signs. Approximately 70% of all EOCs are Stage III or Stage IV at diagnosis. To date no cost-effective screening program for ovarian cancer is available. Most of FDA-approved cancer biomarkers including CA-125 (Cancer antigen 125) are used to monitor disease. In this research, we used modified 2D-DIGE established before, to analyze plasma of disease and disease-free state from four patients with early stage ovarian cancer. Tumour cells can secrete some protease to cleavag

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22

Siphugu, Steven Mbonalo. "The efficiency of ultrasonorgraphy in monitoring ovarian structures and foetal development in goats, sheep and cattle as verified through laparoscopy and laparotomy." Diss., 2018. http://hdl.handle.net/11602/1148.

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MSCAGR (Animal Science)<br>Department of Animal Science<br>The main purpose of this study was to assess the efficiency of ultrasonography in monitoring reproductive organs, pregnancy diagnosis, and foetal gender identification and to verify its reliability by laparoscopy and laparotomy, where applicable. Reproductive organs, pregnancy diagnosis and gender of the foetus were examined by A-mode ultrasound using 3.0 - 8.0 MHz trans-rectal transducer. A Sony Olympus Model laparoscope with a camera transducer was used to monitor the reproductive organs and pregnancy diagnosis. In monitoring the fol

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23

Odendaal, Paul Nielen. "Seasonal changes in the ovarian structure of the cape fur seal (Arctocephalus pusillus pusillus)." Diss., 2000. http://hdl.handle.net/2263/30147.

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24

Austoker, Joyce. "On the structure and development of the bursa ovarica and infundibulum tubae in Elephantulus myurus jamesoni : with special reference to the ovarial bursa in mammals, and to its function." Thesis, 2014. http://hdl.handle.net/10539/15744.

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25

Liao, Wei-Ning, and 廖唯甯. "Structure and expression of ovarian connexin Je-Cx34.4 and Je-Cx43 in Japanese eel (Anguilla japonica)." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/58120182897594687728.

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碩士<br>國立臺灣大學<br>漁業科學研究所<br>103<br>Gap junctions (GJs), composed of connexin (Cx) protein subunits, allow direct communication through conduits between neighboring cells in vertebrate. From teleost to mammals, throughout oogenesis, cell-cell communication via GJs between oocytes and surrounding follicle cells, and/or amongst follicle cells is required for successful follicular development. However, the functions and regulation of ovarian GJs or Cx during earlier stages of oogenesis, such as previtellogenic and vitellogenic stages, mostly remain to explored. To gain a fundamental understanding o

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26

James, Terrence. "A structural examination of the Crimean-Congo Hemorrhagic Fever Virus Otu protease domain in the presence of the Ubiquitin and ISG15 substrates." 2010. http://hdl.handle.net/1993/3988.

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Immune cytokines tumor necrosis factor alpha and type I interferons provide front-line defense against viral infection and are regulated in part by ubiquitin (Ub) and Ub-like molecules. Ubiquitin and Ub-like molecule ISG15 share a conserved C-terminal motif where a terminal glycine residue becomes attached to cellular target proteins. Nairoviruses and arteriviruses contain an ovarian tumor domain-containing protease (OTU protease) that was found to corrupt pathways by removing Ub or ISG15 from target proteins. This broad substrate specificity is unlike mammalian deubiquitinating enzymes, wh

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27

Suresh, P. S. "Studies On Intracrine Regulators Of Ovarian Function : Examination Of Progesterone Action On Structure And Function Of Corpus Luteum In The Monkey." Thesis, 2009. http://etd.iisc.ernet.in/handle/2005/1347.

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The control of reproductive cycles in higher primates is largely dependent on negative and positive feedback mechanisms by both steroidal and non-steroidal substances of the ovaries which regulate the function of hypothalamo-pituitary system. To gain insights into the role of INH A, the non steroidal ovarian hormone in the feedback control of pituitary FSH secretion, studies were conducted to examine the interrelationships of hormones throughout the menstrual cycle of the bonnet macaque. The findings of chapter II provide a detailed description of endocrine hormone profile during the menstrual

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28

Liau, Hao-Han, and 廖浩涵. "Synthesis of 3,5-1H-Diarylpyrazole Derivatives and Structure-Activity Relationship Study of Growth Inhibition Against SK-OV-3 Ovarian Cancer Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/80463070730440190134.

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碩士<br>淡江大學<br>化學學系碩士班<br>97<br>In this dissertation, we synthesized a series of 3, 5-diaryl-1H-pyrazole derivatives containing a simple molecular scaffold for the study of growth inhibitory effect in cancer cells. We took advantage of a practical synthetic route to synthesize these derivatives as shown in the followings: The 1,3-diketone intermediate was prepared by the treatment of acetophenone and benzoyl chloride in the presence of lithium bis(trimethylsilyl)amide (LiHMDS) in toluene solution. Without further purification, 1,3-diketone intermediate was treated with hydrazine and heated at r

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29

Teesdale-Spittle, P. H., Klaus Pors, R. Brown, Laurence H. Patterson, and J. A. Plumb. "Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells." 2005. http://hdl.handle.net/10454/3191.

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No<br>A novel series of 1,4-disubstituted aminoanthraquinones were prepared by ipso-displacement of 1,4-difluoro-5,8-dihydroxyanthraquinones by hydroxylated piperidinyl- or pyrrolidinylalkyl-amino side chains. One aminoanthraquinone (13) was further derivatized to a chloropropyl-amino analogue by treatment with triphenylphosphine-carbon tetrachloride. The compounds were evaluated in the A2780 ovarian cancer cell line and its cisplatin-resistant variants (A2780/ cp70 and A2780/MCP1). The novel anthraquinones were shown to possess up to 5-fold increased potency against the cisplatin-resistant ce

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