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Articoli di riviste sul tema "Perillyl alcohol"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 5 febbraio 2022

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1

Wagner, Johanna E., Janice L. Huff, William L. Rust, Karl Kingsley e George E. Plopper. "Perillyl Alcohol Inhibits Breast Cell Migration without Affecting Cell Adhesion". Journal of Biomedicine and Biotechnology 2, n. 3 (2002): 136–40. http://dx.doi.org/10.1155/s1110724302207020.

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The monoterpene d-limonene exhibits chemotherapeutic and chemopreventive potential in breast cancer patients. D-limonene and its related compounds, perillyl alcohol and perillyl aldehyde, were chosen as candidate drugs for application in a screen for nontoxic inhibitors of cell migration. Using the nontumorigenic human breast cell line MCF-10A, we delineated the toxicity as greatest for the perillyl aldehyde, intermediate for perillyl alcohol, and least for limonene. A noncytotoxic concentration of 0.5 mmol/L perillyl alcohol inhibited the migration, while the same concentration of limonene failed to do so. Adhesion of the MCF-10A cell line and the human breast cancer cell line MDA-MB 435 to fibronectin was unaffected by 1.5 mmol/L perillyl alcohol. 0.4 mmol/L perillyl alcohol inhibited the growth of MDA-MB 435 cells. All migration-inhibiting concentrations of perillyl alcohol for MDA-MB 435 cells proved to be toxic. These results suggest that subtoxic doses of perillyl alcohol may have prophylactic potential in the treatment of breast cancer.

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2

Menéndez, Pilar, Carlos García, Paula Rodríguez, Patrick Moyna e Horacio Heinzen. "Enzymatic systems involved in D-limonene biooxidation". Brazilian Archives of Biology and Technology 45, n. 2 (giugno 2002): 111–14. http://dx.doi.org/10.1590/s1516-89132002000200001.

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The biooxidation of limonene by an Aspergillus strain resulted in the production of perillyl alcohol and short chain fatty acids. Addition of ketoconazole, a known inhibitor of cytochrome P450 oxydase, eliminated the production of free acids, but did not affect biotransformation to perillyl alcohol.

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3

van Beilen, Jan B., René Holtackers, Daniel Lüscher, Ulrich Bauer, Bernard Witholt e Wouter A. Duetz. "Biocatalytic Production of Perillyl Alcohol from Limonene by Using a Novel Mycobacterium sp. Cytochrome P450 Alkane Hydroxylase Expressed in Pseudomonas putida". Applied and Environmental Microbiology 71, n. 4 (aprile 2005): 1737–44. http://dx.doi.org/10.1128/aem.71.4.1737-1744.2005.

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ABSTRACT A number of oxygenated monoterpenes present at low concentrations in plant oils have anticarcinogenic properties. One of the most promising compounds in this respect is (−)-perillyl alcohol. Since this natural product is present only at low levels in a few plant oils, an alternative, synthetic source is desirable. Screening of 1,800 bacterial strains showed that many alkane degraders were able to specifically hydroxylate l-limonene in the 7 position to produce enantiopure (−)-perillyl alcohol. The oxygenase responsible for this was purified from the best-performing wild-type strain, Mycobacterium sp. strain HXN-1500. By using N-terminal sequence information, a 6.2-kb ApaI fragment was cloned, which encoded a cytochrome P450, a ferredoxin, and a ferredoxin reductase. The three genes were successfully coexpressed in Pseudomonas putida by using the broad-host-range vector pCom8, and the recombinant converted limonene to perillyl alcohol with a specific activity of 3 U/g (dry weight) of cells. The construct was subsequently used in a 2-liter bioreactor to produce perillyl alcohol on a scale of several grams.

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4

Geoghegan, Kimberly, e Paul Evans. "Synthesis of (+)-perillyl alcohol from (+)-limonene". Tetrahedron Letters 55, n. 8 (febbraio 2014): 1431–33. http://dx.doi.org/10.1016/j.tetlet.2014.01.039.

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5

Loutrari, Heleni, Maria Hatziapostolou, Vassoula Skouridou, Evangelia Papadimitriou, Charis Roussos, Fragiskos N. Kolisis e Andreas Papapetropoulos. "Perillyl Alcohol Is an Angiogenesis Inhibitor". Journal of Pharmacology and Experimental Therapeutics 311, n. 2 (21 giugno 2004): 568–75. http://dx.doi.org/10.1124/jpet.104.070516.

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6

Xie, Fan, Nathan A. Seifert, Matthias Heger, Javix Thomas, Wolfgang Jäger e Yunjie Xu. "The rich conformational landscape of perillyl alcohol revealed by broadband rotational spectroscopy and theoretical modelling". Physical Chemistry Chemical Physics 21, n. 28 (2019): 15408–16. http://dx.doi.org/10.1039/c9cp03028j.

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7

Benedito, Rubens Batista, Mateus Feitosa Alves, Wendel Batista Pereira, Paula de Arruda Torres, Jéssica Pereira Costa, Adriana da Rocha Tomé, Rita de Cássia da Silveira e Sá et al. "Perillyl Alcohol: Antinociceptive Effects and Histopathological Analysis in Rodent Brains". Natural Product Communications 12, n. 9 (settembre 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200902.

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Perillyl alcohol (PA) is a natural compound found in essential oils. In this study, the antinociceptive activity of PA was evaluated using acetic acid and formalin tests. The involvement of the opioid system in its mechanism of action was investigated. Potential histological changes in the hippocampus and striatum were also assessed. In the acetic acid induced writhing tests, the mice pretreated with PA exhibited significant reductions in writhing. PA inhibited formalin injected paw licking response, and naloxone partially reversed the antinociceptive activity of perillyl alcohol during the writhing test. And as for the histopathological evaluation, PA did not cause significant tissue changes. This study suggests that PA possesses antinociceptive effects without significant hippocampus or striatum neurotoxicity, and that its activity involves opioid.

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8

García-Carnelli, Carlos, Paula Rodríguez, Horacio Heinzen e Pilar Pilar Menéndez. "Influence of Culture Conditions on the Biotransformation of (+)-Limonene by Aspergillus niger". Zeitschrift für Naturforschung C 69, n. 1-2 (1 febbraio 2014): 61–67. http://dx.doi.org/10.5560/znc.2013-0048.

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The influence of the cultivation system and of the culture medium on the biotransformation of (+)-limonene by a strain of Aspergillus niger was investigated. Biooxidation products were obtained in all conditions tested. Using a laboratory bioreactor, six terpenes were identified in every medium, predominantly terpineols and carveols, whereas terpinen-4-ol and perillyl alcohol were the only terpenes found when flasks were used for culture. Perillyl alcohol and carveols predominated when the medium was tryptic soy broth (TSB), whereas the formation of terpineols was clearly favoured in malt broth (MB). Thus, there was a marked influence of the culture conditions on the results of the biotransformation. Changes in the conditions led to variations both in the type and relative amount of products obtained.

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9

Said, Bastián, Iván Montenegro, Manuel Valenzuela, Yusser Olguín, Nelson Caro, Enrique Werner, Patricio Godoy, Joan Villena e Alejandro Madrid. "Synthesis and Antiproliferative Activity of New Cyclodiprenyl Phenols against Select Cancer Cell Lines". Molecules 23, n. 9 (12 settembre 2018): 2323. http://dx.doi.org/10.3390/molecules23092323.

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Six new cyclodiprenyl phenols were synthesized by direct coupling of perillyl alcohol and the appropriate phenol. Their structures were established by IR, HRMS and mainly NMR. Three human cancer cell lines—breast (MCF-7), prostate (PC-3) and colon (HT-29)—were used in antiproliferative assays, with daunorubicin and dunnione as positive controls. Results described in the article suggest that dihydroxylated compounds 2–4 and monohydroxylated compound 5 display selectivity against cancer cell lines, cytotoxicity, apoptosis induction, and mitochondrial membrane impairment capacity. Compound 2 was identified as the most effective of the series by displaying against all cancer cell lines a cytotoxicity close to dunnione antineoplastic agent, suggesting that the cyclodiprenyl phenols from perillyl alcohol deserve more extensive investigation of their potential medicinal applications.

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10

Kiran, Ismail. "Microbial Hydroxylation of S-(-)-Perillyl Alcohol by Fusarium heterosporium". Natural Product Communications 6, n. 12 (dicembre 2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601203.

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S-(-)-Perillyl alcohol ( p-mentha-1, 8-diene-7-ol) (1) (500 mg) was converted by Fusarium heterosporium ATCC 15625 over 10 days at 25°C to a new metabolite, 1,2-dihydroxyperillyl alcohol ( p-mentha-8-en-1,2,7-triol) (3) in a yield of 13% (70 mg). The structure of 3 was established by IR and NMR spectroscopic, specific rotation, and mass spectral studies.

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11

Fatima, Zeeshan. "Antimycobacterial Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol". SOJ Microbiology & Infectious Diseases 4, n. 4 (5 dicembre 2016): 1–6. http://dx.doi.org/10.15226/sojmid/4/4/00160.

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12

Geoghegan, Kimberly, e Paul Evans. "ChemInform Abstract: Synthesis of (+)-Perillyl Alcohol from (+)-Limonene." ChemInform 45, n. 30 (10 luglio 2014): no. http://dx.doi.org/10.1002/chin.201430198.

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13

Gupta, Abhishek, e Paul B. Myrdal. "Development of a perillyl alcohol topical cream formulation". International Journal of Pharmaceutics 269, n. 2 (gennaio 2004): 373–83. http://dx.doi.org/10.1016/j.ijpharm.2003.09.026.

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14

Miastkowska, Małgorzata, e Paweł Śliwa. "Influence of Terpene Type on the Release from an O/W Nanoemulsion: Experimental and Theoretical Studies". Molecules 25, n. 12 (13 giugno 2020): 2747. http://dx.doi.org/10.3390/molecules25122747.

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The interaction between a drug molecule and its carrier’s components is an important factor which influences the drug release profile. For this purpose, molecular dynamics (MD) may be the in silico tool which can help to understand the mechanism of drug loading/release. The aim of this work is to explain the effect of interactions between different types of terpenes, namely perillyl alcohol, forskolin, ursolic acid, and the nanoemulsion droplet core, on the release by means of experimental and theoretical studies. The basic nanoemulsion was composed of caprylic/capric triglyceride as the oil phase, polysorbate 80 as the emulsifier, and water. The in vitro release tests from a terpene-loaded nanoemulsion were carried out to determine the release profiles. The behavior of terpenoids in the nanoemulsion was also theoretically investigated using the molecular dynamics method. The forskolin-loaded nanoemulsion showed the highest percentage of drug release (almost 80% w/w) in contrast to ursolic acid and perillyl alcohol-loaded nanoemulsions (about 53% w/w and 19% w/w, respectively). The results confirmed that the kinetic model of release was terpene-type dependent. The zero-order model was the best to describe the ursolic acid release profile, while the forskolin and the perillyl alcohol followed a first-order and Higuchi model, respectively. Molecular dynamics simulations, especially energetical analysis, confirmed that the driving force of terpenes diffusion from nanoemulsion interior was their interaction energy with a surfactant.

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15

Matos, Jesus M., C. Max Schmidt, Howard J. Thomas, Oscar W. Cummings, Eric A. Wiebke, James A. Madura, Loehrer J. Patrick e P. L. Crowell. "A Pilot Study of Perillyl Alcohol in Pancreatic Cancer". Journal of Surgical Research 147, n. 2 (giugno 2008): 194–99. http://dx.doi.org/10.1016/j.jss.2008.02.005.

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16

Cho, Hee-Yeon, Weijun Wang, Niyati Jhaveri, Shering Torres, Joshua Tseng, Michelle N. Leong, David Jungpa Lee et al. "Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas". Molecular Cancer Therapeutics 11, n. 11 (28 agosto 2012): 2462–72. http://dx.doi.org/10.1158/1535-7163.mct-12-0321.

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17

Rajesh, Deepika, Rachelle A. Stenzel e Steven P. Howard. "Perillyl Alcohol as a Radio-/Chemosensitizer in Malignant Glioma". Journal of Biological Chemistry 278, n. 38 (12 giugno 2003): 35968–78. http://dx.doi.org/10.1074/jbc.m303280200.

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18

Stark, M. Jennifer, Yvette D. Burke, Jamie H. McKinzie, A. Siar Ayoubi e Pamela L. Crowell. "Chemotherapy of pancreatic cancer with the monoterpene perillyl alcohol". Cancer Letters 96, n. 1 (settembre 1995): 15–21. http://dx.doi.org/10.1016/0304-3835(95)03912-g.

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19

Erland, Lauren AE, Christopher R. Bitcon, Ashley D. Lemke e Soheil S. Mahmoud. "Antifungal Screening of Lavender Essential oils and Essential Oil Constituents on three Post-harvest Fungal Pathogens". Natural Product Communications 11, n. 4 (aprile 2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100427.

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A growing body of literature indicates that many synthetic pesticides have adverse effects on human, animal, and environmental health. As a result, plant-derived natural products are quickly gaining momentum as safer and less ecologically damaging alternatives due to their low toxicity, high biodegradability, and good specificity. Essential oils of Lavandula angustifolia, Lavandula x intermedia cv Grosso, and Lavandula x intermedia cv Provence as well as various mono- and sesquiterpene essential oil constituents were tested in order to assess their antifungal potential on three important agricultural pathogens: Botrytis cinerea, Mucor piriformis, and Penicillium expansum. Fungal susceptibility testing was performed using disk diffusion assays. The majority of essential oil constituents tested did not have a significant effect; however, 3-carene, carvacrol, geraniol, nerol and perillyl alcohol demonstrated significant inhibition at concentrations as low as 1 μL/mL. In vivo testing using strawberry fruit as a model system supported in vitro results and revealed that perillyl alcohol, carvacrol and 3-carene were effective in limiting infection by postharvest pathogens.

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20

Hui, Zi, Meihui Zhang, Lin Cong, Mingyu Xia e Jinhua Dong. "Synthesis and Antiproliferative Effects of Amino-Modified Perillyl Alcohol Derivatives". Molecules 19, n. 5 (22 maggio 2014): 6671–82. http://dx.doi.org/10.3390/molecules19056671.

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21

Matos, Jesus M., Christian M. Schmidt, Thomas J. Howard, Oscar W. Cummings, Eric A. Wiebke, James A. Madura, Patrick J. Loehrer e Pamela L. Crowell. "QS104. A Pilot Study of Perillyl Alcohol in Pancreatic Cancer". Journal of Surgical Research 144, n. 2 (febbraio 2008): 309. http://dx.doi.org/10.1016/j.jss.2007.12.344.

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22

Yeruva, Laxmi, Casey Hall, John Abiodun Elegbede e Stephen W. Carper. "Perillyl alcohol and methyl jasmonate sensitize cancer cells to cisplatin". Anti-Cancer Drugs 21, n. 1 (gennaio 2010): 1–9. http://dx.doi.org/10.1097/cad.0b013e32832a68ad.

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23

Nandurkar, Nitin S., Jianjun Zhang, Qing Ye, Larissa V. Ponomareva, Qing-Bai She e Jon S. Thorson. "The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity". Journal of Medicinal Chemistry 57, n. 17 (25 agosto 2014): 7478–84. http://dx.doi.org/10.1021/jm500870u.

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24

Lee, Chong Ho, Kyung Ho Row, Youn-Woo Lee, Jae-Duck Kim e Youn Yong Lee. "SUPERCRITICAL FLUID EXTRACTION OF PERILLYL ALCOHOL IN KOREAN ORANGE PEEL". Journal of Liquid Chromatography & Related Technologies 24, n. 13 (31 agosto 2001): 1987–96. http://dx.doi.org/10.1081/jlc-100104440.

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25

Silva, Eduardo, Filipe Oliveira, Joana M. Silva, Ana Matias, Rui L. Reis e Ana Rita C. Duarte. "Optimal Design of THEDES Based on Perillyl Alcohol and Ibuprofen". Pharmaceutics 12, n. 11 (20 novembre 2020): 1121. http://dx.doi.org/10.3390/pharmaceutics12111121.

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Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratios. Our comprehensive strategy includes the characterization of their thermal and structural behavior to identify the molar ratios that successfully form deep eutectic systems. The in vitro solubility of the different systems prepared has demonstrated that, unlike other reported examples, the presence of the terpene did not affect the solubility of the anti-inflammatory agent in a physiological simulated media. The biological performance of the systems was studied in terms of their antimicrobial activity against a wide panel of microorganisms. The examined THEDES showed relevant antimicrobial activity against all tested microbial strains, with the exception of P. aeruginosa. A synergistic effect from the combination of POH and IBU as a eutectic system was verified. Furthermore, the cytotoxic profile of these eutectic systems towards colorectal cancer (CRC) in vitro cell models was also evaluated. The results provide the indication that the cell viability varies in a dose-dependent manner, with a selective THEDES action towards CRC cells. With tunable bioactivities in a ratio-dependent manner, THEDES enhanced the antimicrobial and anticancer properties, representing a possible alternative to conventional therapies. Therefore, this study provides foreseeable indications about the utility of THEDES based on POH and IBU as strong candidates for novel active pharmaceutical systems.

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26

Imamura, Mitsuru, Oh Sasaki, Katsuhide Okunishi, Kazuyuki Nakagome, Hiroaki Harada, Kimito Kawahata, Ryoichi Tanaka, Kazuhiko Yamamoto e Makoto Dohi. "Perillyl alcohol suppresses antigen-induced immune responses in the lung". Biochemical and Biophysical Research Communications 443, n. 1 (gennaio 2014): 266–71. http://dx.doi.org/10.1016/j.bbrc.2013.11.106.

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27

Fulton, Gregory J., Lizzie Barber, Einar Svendsen, Per-Otto Hagen e Mark G. Davies. "Oral Monoterpene Therapy (Perillyl Alcohol) Reduces Vein Graft Intimal Hyperplasia". Journal of Surgical Research 69, n. 1 (aprile 1997): 128–34. http://dx.doi.org/10.1006/jsre.1997.5047.

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28

Durço, Aimée Obolari, Lino Sérgio Rocha Conceição, Diego Santos de Souza, Carlos Anselmo Lima, Jullyana de Souza Siqueira Quintans e Márcio Roberto Viana dos Santos. "Perillyl alcohol as a treatment for cancer: A systematic review". Phytomedicine Plus 1, n. 3 (agosto 2021): 100090. http://dx.doi.org/10.1016/j.phyplu.2021.100090.

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29

Pires Mello, Camilly, Thereza Quirico-Santos, Lídia Fonte Amorim, Viveca Giongo Silva, Lucianne Madeira Fragel, David C. Bloom e Izabel Palmer Paixão. "Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus". Antiviral Therapy 25, n. 1 (2019): 1–11. http://dx.doi.org/10.3851/imp3315.

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Miastkowska, Malgorzata, Monika Konieczna, Elwira Lason, Malgorzata Tabaszewska, Elzbieta Sikora e Jan Ogonowski. "The Release of Perillyl Alcohol from the Different Kind of Vehicles". Current Pharmaceutical Biotechnology 19, n. 7 (1 ottobre 2018): 573–80. http://dx.doi.org/10.2174/1389201019666180730165330.

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Chen, Thomas, Clovis da Fonseca e Axel Schönthal. "Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development". International Journal of Molecular Sciences 19, n. 12 (6 dicembre 2018): 3905. http://dx.doi.org/10.3390/ijms19123905.

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Intracranial malignancies, such as primary brain cancers and brain-localized metastases derived from peripheral cancers, are particularly difficult to treat with therapeutic agents, because the blood-brain barrier (BBB) effectively minimizes brain entry of the vast majority of agents arriving from the systemic circulation. Intranasal administration of cancer drugs has the potential to reach the brain via direct nose-to-brain transport, thereby circumventing the obstacle posed by the BBB. However, in the field of cancer therapy, there is a paucity of studies reporting positive results with this type of approach. A remarkable exception is the natural compound perillyl alcohol (POH). Its potent anticancer activity was convincingly established in preclinical studies, but it nonetheless failed in subsequent clinical trials, where it was given orally and displayed hard-to-tolerate gastrointestinal side effects. Intriguingly, when switched to intranasal delivery, POH yielded highly promising activity in recurrent glioma patients and was well tolerated. As of 2018, POH is the only intranasally delivered compound in the field of cancer therapy (outside of cancer pain) that has advanced to active clinical trials. In the following, we will introduce this compound, summarize its molecular mechanisms of action, and present the latest data on its clinical evaluation as an intranasally administered agent for glioma.

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KOYAMA, MAKOTO, YOSHIHIRO SOWA, TOSHIAKI HITOMI, YOSUKE IIZUMI, MOTOKI WATANABE, TOMOYUKI TANIGUCHI, MASAMI ICHIKAWA e TOSHIYUKI SAKAI. "Perillyl alcohol causes G1 arrest through p15INK4b and p21WAF1/Cip1 induction". Oncology Reports 29, n. 2 (6 dicembre 2012): 779–84. http://dx.doi.org/10.3892/or.2012.2167.

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Murren, John R., Giuseppe Pizzorno, Susan A. DiStasio, Anne McKeon, Kathleen Peccerillo, Ashwin Gollerkari, Walter McMurray et al. "Phase I Study of Perillyl Alcohol in Patients with Refractory Malignancies". Cancer Biology & Therapy 1, n. 2 (7 marzo 2002): 130–35. http://dx.doi.org/10.4161/cbt.57.

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Alonso-Gutierrez, Jorge, Rossana Chan, Tanveer S. Batth, Paul D. Adams, Jay D. Keasling, Christopher J. Petzold e Taek Soon Lee. "Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production". Metabolic Engineering 19 (settembre 2013): 33–41. http://dx.doi.org/10.1016/j.ymben.2013.05.004.

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Ahn, Ki-Jung, Chung K. Lee, Eun Kyung Choi, Robert Griffin, Chang W. Song e Heon Joo Park. "Cytotoxicity of perillyl alcohol against cancer cells is potentiated by hyperthermia". International Journal of Radiation Oncology*Biology*Physics 57, n. 3 (novembre 2003): 813–19. http://dx.doi.org/10.1016/s0360-3016(03)00737-5.

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Fischer, Juliana de Saldanha da Gama, Lujian Liao, Paulo C. Carvalho, Valmir C. Barbosa, Gilberto B. Domont, Maria da Gloria da Costa Carvalho e John R. Yates. "Dynamic proteomic overview of glioblastoma cells (A172) exposed to perillyl alcohol". Journal of Proteomics 73, n. 5 (marzo 2010): 1018–27. http://dx.doi.org/10.1016/j.jprot.2010.01.003.

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Ansari, Moiz A., Zeeshan Fatima e Saif Hameed. "Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans". PLOS ONE 11, n. 9 (14 settembre 2016): e0162465. http://dx.doi.org/10.1371/journal.pone.0162465.

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LEE, YOUN WOO, CHONG HO LEE, JAE DUCK KIM, YOUN YONG LEE e KYUNG HO ROW. "Extraction of Perillyl Alcohol in Korean Orange Peel by Supercritical CO2". Separation Science and Technology 35, n. 7 (7 gennaio 2000): 1069–76. http://dx.doi.org/10.1081/ss-100100211.

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Berchtold, Craig M., Kai-Shun Chen, Shigeki Miyamoto e Michael N. Gould. "Perillyl Alcohol Inhibits a Calcium-Dependent Constitutive Nuclear Factor-κB Pathway". Cancer Research 65, n. 18 (15 settembre 2005): 8558–66. http://dx.doi.org/10.1158/0008-5472.can-04-4072.

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40

Ren, Zhibin, e Michael N. Gould. "Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol". Cancer Letters 76, n. 2-3 (30 gennaio 1994): 185–90. http://dx.doi.org/10.1016/0304-3835(94)90396-4.

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d'Alessio, Patrizia A., Jean-François Bisson e Marie C. Béné. "Anti-Stress Effects of d-Limonene and Its Metabolite Perillyl Alcohol". Rejuvenation Research 17, n. 2 (aprile 2014): 145–49. http://dx.doi.org/10.1089/rej.2013.1515.

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Sundin, Tabetha, Dennis M. Peffley, David Gauthier e Patricia Hentosh. "The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells". Biochimie 94, n. 12 (dicembre 2012): 2639–48. http://dx.doi.org/10.1016/j.biochi.2012.07.028.

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Row, Kyung Ho, Chong Ho Lee e Ji Hoon Kang. "Parameter estimation of perillyl alcohol in RP-HPLC by moment analysis". Biotechnology and Bioprocess Engineering 7, n. 1 (febbraio 2002): 16–20. http://dx.doi.org/10.1007/bf02935874.

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Garcia, Diogo G., Lidia M. F. Amorim, Mauro V. de Castro Faria, Aline S. Freire, Ricardo E. Santelli, Clóvis O. Da Fonseca, Thereza Quirico-Santos e Patricia Burth. "The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor". Molecular and Cellular Biochemistry 345, n. 1-2 (6 agosto 2010): 29–34. http://dx.doi.org/10.1007/s11010-010-0556-9.

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Morgan-Meadows, Sherry, Sarita Dubey, Michael Gould, Kendra Tutsch, Rebecca Marnocha, Rhoda Arzoomanin, Dona Alberti et al. "Phase I trial of perillyl alcohol administered four times daily continuously". Cancer Chemotherapy and Pharmacology 52, n. 5 (1 novembre 2003): 361–66. http://dx.doi.org/10.1007/s00280-003-0684-y.

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Yeruva, Laxmi, Keon J. Pierre, Abiodun Elegbede, Robert C. Wang e Stephen W. Carper. "Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells". Cancer Letters 257, n. 2 (novembre 2007): 216–26. http://dx.doi.org/10.1016/j.canlet.2007.07.020.

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Yapa, Asanka S., Tej B. Shrestha, Sebastian O. Wendel, Madumali Kalubowilage, Jing Yu, Hongwang Wang, Marla Pyle et al. "Peptide Nanosponges Designed for the Delivery of Perillyl Alcohol to Glioma Cells". ACS Applied Bio Materials 2, n. 1 (11 dicembre 2018): 49–60. http://dx.doi.org/10.1021/acsabm.8b00305.

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d'Alessio, Patrizia, Massoud Mirshahi, Jean-Francois Bisson e Marie Bene. "Skin Repair Properties of d-Limonene and Perillyl Alcohol in Murine Models". Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 13, n. 1 (31 gennaio 2014): 29–35. http://dx.doi.org/10.2174/18715230113126660021.

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Zhang, Zhihong, Haitao Chen, Kenneth K. Chan, Thomas Budd e Ram Ganapathi. "Gas chromatographic–mass spectrometric analysis of perillyl alcohol and metabolites in plasma". Journal of Chromatography B: Biomedical Sciences and Applications 728, n. 1 (maggio 1999): 85–95. http://dx.doi.org/10.1016/s0378-4347(99)00065-1.

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CHANG, HAE C., e PATRICK ORIEL. "Bioproduction of Perillyl Alcohol and Related Monoterpenes by Isolates of Bacillus stearothermophilus". Journal of Food Science 59, n. 3 (maggio 1994): 660–62. http://dx.doi.org/10.1111/j.1365-2621.1994.tb05588.x.

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