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Letteratura scientifica selezionata sul tema "Pharmacological intervention"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 18 febbraio 2022

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Articoli di riviste sul tema "Pharmacological intervention"

&NA;. "PHARMACOLOGICAL INTERVENTION". Gastroenterology Nursing 33, n. 6 (2010): 446–47. http://dx.doi.org/10.1097/sga.0b013e318200c8b9.

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Underwood, S. R. "MRI with pharmacological intervention". International Journal of Cardiac Imaging 11, S1 (marzo 1995): 37. http://dx.doi.org/10.1007/bf01142216.

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Melander. "Pharmacological intervention: the antidiabetic approach". European Journal of Clinical Investigation 28 (settembre 1998): 23–26. http://dx.doi.org/10.1046/j.1365-2362.1998.0280s2023.x.

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Rissanen. "Pharmacological intervention: the antiobesity approach". European Journal of Clinical Investigation 28 (settembre 1998): 27–30. http://dx.doi.org/10.1046/j.1365-2362.1998.0280s2027.x.

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Jain, Raka, Pradipta Majumder e Tina Gupta. "Pharmacological Intervention of Nicotine Dependence". BioMed Research International 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/278392.

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Nicotine dependence is a major cause of mortality and morbidity all over the world. Various medications have been tried to treat nicotine dependence including nicotine replacement therapy, bupropion, and varenicline. A newer venture to nicotine dependence treatment is a nicotine vaccine which is yet to get footsteps in common practice. The present review assimilates various pharmacotherapeutic measures to address nicotine dependence. However, it is to be noted that psychological interventions, when combined with pharmacotherapy, offer the greatest benefits to the patients.

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Gunn, A. J., C. E. Williams, L. Bennet, C. J. Cook e P. D. Gluckman. "Perinatal Cerebral Asphyxia: Pharmacological Intervention". Fetal Diagnosis and Therapy 3, n. 1-2 (1988): 98–107. http://dx.doi.org/10.1159/000263339.

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Choi, Geun Joo, Hee-Kyeong Seong e Hyun Kang. "Pharmacological intervention for ambulatory surgery". Medicine 99, n. 32 (7 agosto 2020): e21580. http://dx.doi.org/10.1097/md.0000000000021580.

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Richards, Lisa. "Behavioral intervention enhances pharmacological therapy". Nature Reviews Urology 6, n. 7 (luglio 2009): 348. http://dx.doi.org/10.1038/nrurol.2009.117.

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Lithgow, Gordon J., Matthew S. Gill, Anders Olsen e James N. Sampayo. "Pharmacological intervention in invertebrate aging". AGE 27, n. 3 (settembre 2005): 213–23. http://dx.doi.org/10.1007/s11357-005-3625-3.

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Beckand, Thomas, e Gerhard W. Bielenberg. "Pharmacological intervention of cerebral ischemia". Trends in Pharmacological Sciences 7 (gennaio 1986): 425–28. http://dx.doi.org/10.1016/0165-6147(86)90409-8.

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Tesi sul tema "Pharmacological intervention"

Tsoumpra, Maria. "Targeting the mevalonate pathway for pharmacological intervention". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:fe945074-e645-4c1d-9598-e28b51a43cca.

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Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorption. The main aim of this thesis is to investigate the interaction of N-BPs with FPPS in order to gain further insights into the mechanism of drug inhibition. Kinetic and crystallographic studies following site-directed mutagenesis of FPPS reveal key residues involved in stabilization of carbocation intermediate, substrate binding and formation of a tight enzyme-inhibitor complex. The aromatic ring of Tyr204 is involved in N-BP binding but not in the catalytic mechanism, where the hydroxyl moiety plays an important role. Lys200 is implicated in regulation of substrate binding, product specificity and enzyme isomerization which leads to a tight binding inhibition. Phe239 is considered important for the FPPS C-terminal switch which stabilizes substrate binding and promotes the inhibitor induced isomerized state. The highly conserved Arg112, Asp103 and Asp107 are pivotal for catalysis. Successful purification of the full length of Rab geranylgeranyl transferase (RGGT) complex downstream of the FPPS in the mevalonate pathway was achieved and may lead to co-crystallization with BP analogues and identification of the putative site of drug binding. Investigation of the in vitro effect of N-BPs on osteoclastogenesis suggest a correlation with FPPS inhibition kinetics for the most potent N-BPs but indicate an alternative mechanism of the disruption of bone resorption by alendronate. Together these results highlight the importance of the multiple interactions of N-BPs with side-chain residues of FPPS which dictate their strength of binding and advance the understanding of their pharmacophore effect.

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Hastings, Erica, e University of Lethbridge Faculty of Arts and Science. "Environmental and pharmacological intervention following cortical brain injury". Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/180.

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This thesis focuses on the effects of pharmacological and environmental interventions following perinatal prefrontal cortex lesions. Rats given postnatal day 3 medial prefrontal cortex lesions were provided with one of the following treatments: basic fibroblast growth factor (bFGF), complex-housing, tactile stimulation, or a combined treatment of both bFGF and tactile stimulation or bFGF and complex-housing. Rats given postnatal day 3 orbital prefrontal cortex lesions were housed in a complex environment. The findings of these studies suggest that bFGF, complex-housing or tactile stimulation are beneficial after early brain injury. The combined treatment of bFGF with complex-housing provides a synergistic effect, as the combined condition is more advantageous than bFGF alone. In contrast, the combined treatment of bFGF with tactile stimulation produced adverse effects. These results suggest that pharmacological and environmental manipulations change cortical plasticity and therefore functional recovery after neonatal cortical injury.
xv, 177 leaves : ill. (some col.) ; 29 cm.

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Strigo, Irina A. "Visceral and cutaneous pain : neural correlates and pharmacological intervention". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38521.

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Our brain is involved in processing pain, whether it is superficial cutaneous pain, caused by a scratch or a burn, or deep internal pain, caused by heartburn or gas in the intestines. Moreover, activation of a common cortical network is suggested during different types of pain in humans, implying that as long as the stimulus is painful it will be processed similarly in the cerebral cortex. However, no one has yet made direct comparison between superficial and deep pain of similar intensity and location; direct comparison is necessary in order to see how superficial pain relates to a more clinically relevant deep pain and to further our understanding of the latter.
In three separate studies, the perception of visceral and cutaneous pain in humans was examined using psychophysical, brain imaging and pharmacological approaches, respectively. The first study revealed that for a similar given intensity, duration and location, visceral pain is more unpleasant, more varied qualitatively, more diffuse and more persistent after stimulation has ended, suggesting that there are some significant distinctions in the neural processes of external and internal pain in humans. The second study examined such processes with functional magnetic resonance imaging (fMRI), disclosing substantial differences in cortical processing of sensory information from skin and viscera, including limbic areas associated with the emotional component of pain (anterior cingulate and insular cortices), and sensory areas (primary somatosensory cortex). In addition, several similar cortical areas were activated by both superficial and deep pain, consistent with the existence of a common pain network independent of the nature of pain. The final study examined a possible divergence in pharmacological processes underlying deep and superficial pain, which could arise from differences in neuronal processing. The findings revealed that NMDA-receptors mediate both visceral and cutaneous pain in humans, yet the affect of visceral pain might be more susceptible to their blockers, which may be a potential explanation for different treatments of visceral and cutaneous pains.
Together these studies provide direct evidence of the differences and similarities between visceral and cutaneous pain in humans within the perceptual, physiological and pharmacological domains.

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Waldeck, Kristian. "Targets for pharmacological intervention in the bladder and urethra". Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945055.html.

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Witt-Lajeunesse, Alane, e University of Lethbridge Faculty of Arts and Science. "Effects of behavioral therapies and pharmacological intervention in brain damage". Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2001, 2001. http://hdl.handle.net/10133/149.

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Maximizing recovery of function after brain injury is the goal for many neuroscientists and rehabilitation medicine professional alike. To further elucidate the neural mechanisms underlying compensatory changes in brain injury and to determine the possibility of enhancing these changes, three experiments are described. Experiment 1 looks at the effects of structured (skilled reaching) versus functional (enriched environment) training with and without FGF-2, a pharmacological intervention, as treatment paradigms for rehabilitation-induced recovery of function in cortical lesion adult rats. Experiment 2 examines the treatment effects of tactile stimulation to enhance motor abilities in postnatal day 4 rat pups sustaining cortical damage. Finally, experiment 3 explores changes in the cortical motor representation after cortical damage. Results indicate a marked improvement on behavioral testing combing FGF-2 and functional training. Tactile stimulation significantly enhances recovery of motor functions. Post-lesion cortical mapping reveals changes in the motor representation utilizing the adjacent posterior parietal cortex.
xv, 127 leaves : ill. ; 28 cm.

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Qiao, Shuxi. "Pharmacological Modulation of Oxidative and Proteotoxic Stress for Antimelanoma Intervention". Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311348.

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Cumulative evidence suggests that constitutively elevated levels of proteotoxic stress represent a specific vulnerability of malignant cells that can be targeted by pharmacological modulation of the intracellular proteotoxic stress response. According to this emerging mechanism, small molecule stress modulators may induce deviations from protein homeostasis causing cytotoxicity confined to malignant cells already at a high set point of constitutive proteotoxic stress leading to functional impairment and even cell death. In contrast, normal cells with sufficient protein degradation capacity can tolerate the extra dysfunctional protein overload. My graduate research has focused on testing the feasibility of repurposing clinically used non-oncological drugs for experimental chemotherapy targeting metastatic melanoma cells. The following specific aims were pursued: (1) To identify clinically used non-oncological drugs that preferentially induce cytotoxicity in melanoma cells but not primary melanocytes through upregulation of proteotoxic and/or oxidative stress; (2) To explore the specific molecular mechanisms underlying induction of melanoma cell apoptosis by lead compounds focusing on oxidative and proteotoxic stress modulation; (3) To explore efficacy of selected lead compounds for antimelanoma intervention in a murine xenograft model. First, we demonstrate feasibility of using the FDA-approved redox-active D-cysteine-derivative D- penicillamine for chemotherapeutic intervention targeting human A375 melanoma cells in vitro and in vivo through induction of the unfolded protein response (UPR). Second, we demonstrate that the antimicrobial oligopeptide thiostrepton displays dual activity as a selective prooxidant and proteasome inhibitor causing proteotoxic stress that preferentially targets malignant melanoma and multiple myeloma cells. Third, we demonstrate for the first time that the clinically used 4-aminoquinoline antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced melanoma cell death. Taken together, our data indicate the chemotherapeutic potential of small molecule proteotoxic stress inducers and strongly suggest feasibility of repurposing specific non-oncological drugs for proteotoxic stress-directed antimelanoma intervention.

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Johnson, S. P. "Multimodality imaging of tumour pathophysiology and response to pharmacological intervention". Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1463534/.

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This thesis describes the need for imaging the tumour pathophysiological microenvironment in order to understand response to treatment. Specifically looking at tumour vascularisation in in vivo murine xenograft models of disease, response to treatment with vascular disruption is assessed via photoacoustic tomography (PAT) and magnetic resonance imaging (MRI). Photoacoustic imaging is a novel imaging modality based on the detection of ultrasound waves created by the absorption of nano-second pulsed laser energy within tissue chromophores. It has the spectral specificity of optical techniques whilst also achieving the high resolution of ultrasound. Haemoglobin is the main chromophore found in biological tissue and this modality is therefore ideally suited to imaging tumour vascularisation. Using a Fabry-Perot interferometer this thesis demonstrates for the first time the feasibility of using PAT for re-clinical research and the characterisation of typical tumour vascular features in a non-invasive non-ionising manner. Response to different concentrations of a vascular disrupting drug is then demonstrated, with novel insights in to how tumours recover from vascular damage observed. MRI of response to vascular disruption is also presented. As MRI is widely used in the clinic it can serve as a translational tool of novel imaging biomarkers, and serves to further understand the differences in response of pathologically vascularised of tumours. This thesis looks at markers associated with disruption of haemodynamics, using apparent diffusion (ADC) to elucidate onset of necrosis, increase in haemoglobin concentration (R2*) as indication of impaired flow, and arterial spin labelling (ASL) as a marker of tumour blood perfusion. This is shown in both subcutaneous and clinically relevant liver metastasis models. Taken as whole, the results from this thesis indicate that whilst understanding the response of the tumour vasculature to pharmacological intervention is complex, novel imaging techniques can provide invaluable translational information on the pathophysiology of tumours.

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Wong, Philip Siva Vittozzi. "Cognitive enhancers: a pharmacological intervention for the treatment of substance dependence". Thesis, Boston University, 2012. https://hdl.handle.net/2144/31622.

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Thesis (M.A.)--Boston University
PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
Dependence from addictive substances is a serious public health concern in the United States. Alcohol appears to be the most popular abused substance, while cigarette smoking has the highest rates of mortality. Though not as popular, illicit drugs such as cocaine and opioids are able to cause incredible damage to the lives of addicted individuals and to the people around them. The toxic injuries produced in the brain and the presence of withdrawal symptoms often result in cognitive deficits. Individuals that are able to terminate the consumption of drugs often have a hard time regaining their previous cognitive abilities. This partially contributes to the high incidence of relapse, which represents a major problem faced by the medical community. So far treatment has relied on cognitive behavioral therapy and a number of pharmacological agents. Even when combined, these approaches have not yielded satisfying results. For some types of addictions, such as the one for cocaine, there are no approved medications. Therefore research has made tremendous efforts to understand how the brain responds to addictive substances with the hope that such knowledge will lead to new pharmacological treatments. Cognitive enhancers are a promising class of drugs that is under investigation for the treatment of substance dependence. Most of them have been tested for their ability to decrease drug craving and consumption. Some of them are also being examined for their ability to reverse the cognitive deficits produced by previous drug exposure. The present thesis will examine the current literature on four cognitive enhancers: atomoxetine, reboxetine, selegiline and modafinil. Even if still in the preliminary stages, the clinical trials on reboxetine have obtained the highest rate of success. On the other hand, modafinil is the only cognitive enhancer that has been tested for reversing cognitive deficits. Compelling results in a clinical trial make modafinil one of the most exciting projects in this field of research. Atomoxetine and selegiline have mostly failed the clinical stage, but more studies are needed to determine their usefulness. In general, the potential ability to reverse cognitive deficits is not supported by the current literature and more research should be focused in this direction.
2031-01-01

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Shelton, Evan G. "Development and Evaluation of a Personalized Music Intervention for Dementia". Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1547483058896284.

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Garcia, Monica. "Differential Effects of Hydrocortisone on PTSD Symptom Clusters". Kent State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=kent1523196739368854.

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Libri sul tema "Pharmacological intervention"

Beard, Jonathan C. Illicit drug use: Acute and chronic pharmacological intervention. Salisbury, Wiltshire: Quay Books, 1995.

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Al-Nimer, Marwan S. M. Pharmacological intervention in management of neck pain disorders: A review. Hauppauge, N.Y: Nova Science Publishers, 2010.

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Ninot, Gregory. Non-Pharmacological Interventions. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-60971-9.

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Ken'ichi, Kitani, Goto S e Aoba A, a cura di. Pharmacological intervention in aging and age-associated disorders: Proceedings of the Sixth Congress of the International Association of Biomedical Gerontology. New York: New York Academy of Sciences, 1996.

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Naranjo, Claudio A., e Edward M. Sellers, a cura di. Novel Pharmacological Interventions for Alcoholism. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4612-2878-3.

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Ryan, Kirk R. Pharmacologic intervention in the treatment of AIDS. A cura di Friday Lynn E. McLean, Va: Remco, 1992.

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Sammons, Morgan T., e Norman B. Schmidt, a cura di. Combined treatment for mental disorders: A guide to psychological and pharmacological interventions. Washington: American Psychological Association, 2001. http://dx.doi.org/10.1037/10415-000.

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Dieppe, P. A., e R. G. Russell. Osteoarthritis: Current Research and Prospects for Pharmacological Intervention. Hyperion Books, 1991.

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Moulton, Calum D. Novel pharmacological targets. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0013.

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There is a bidirectional relationship between depression and type 2 diabetes (T2D). Patients with comorbid depression and T2D are at high risk of complications and premature mortality. Conventional treatments for depression do not consistently improve diabetes outcomes, despite improving depressive symptoms. Shared mechanisms may underpin both depression and T2D, providing novel pharmacological targets to treat both conditions simultaneously. There are several candidate pathways. For inflammation and vitamin D deficiency, there is good cross-sectional evidence to support an association with depression in T2D. Prospective epidemiological studies are needed to test biological pathways as predictive biomarkers of depression and T2D. Intervention studies are needed to test the modifiability of these pathways. Repurposing of established diabetes treatments may provide a ‘multiple hit’ strategy. The identification and modification of novel biological targets has the potential to treat both depression and T2D, as well as reducing longer term morbidity and mortality.

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Osteoarthritis: current research and prospects for pharmacological intervention: Conference documentation : London, 1988. London: IBC Technical Services, 1988.

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Capitoli di libri sul tema "Pharmacological intervention"

Dulcan, Mina K. "Pharmacological Intervention". In Advanced Abnormal Psychology, 443–71. Boston, MA: Springer US, 1994. http://dx.doi.org/10.1007/978-1-4757-0345-0_23.

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Takano, Masamichi. "Pharmacological Intervention". In Coronary Angioscopy, 217–27. Tokyo: Springer Japan, 2015. http://dx.doi.org/10.1007/978-4-431-55546-9_19.

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Aman, Michael G., e Johannes Rojahn. "Pharmacological Intervention". In Learning Disabilities, 478–525. New York, NY: Springer New York, 1992. http://dx.doi.org/10.1007/978-1-4613-9133-3_16.

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Shinton, Roger, e Gareth Beevers. "Non-pharmacological intervention". In Developments in Cardiovascular Medicine, 127–40. Dordrecht: Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1647-0_9.

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Shinton, Roger A., e Gareth Beevers. "Non-pharmacological intervention". In Practical Management of Hypertension, 113–26. Dordrecht: Springer Netherlands, 1990. http://dx.doi.org/10.1007/978-94-011-3724-9_7.

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Germanò, Antonino F., e Francesco Tomasello. "Strategies for Pharmacological Intervention". In Blood-Brain Barrier Permeability Changes after Subarachnoid Haemorrhage: An Update, 88–108. Vienna: Springer Vienna, 2001. http://dx.doi.org/10.1007/978-3-7091-6194-4_7.

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Ninot, Gregory. "Motives and Facilitators of Non-pharmacological Intervention Use". In Non-Pharmacological Interventions, 167–91. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-60971-9_6.

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Powis, Garth. "Pharmacological Intervention with Signal Transduction". In New Approaches in Cancer Pharmacology: Drug Design and Development, 39–54. Berlin, Heidelberg: Springer Berlin Heidelberg, 1994. http://dx.doi.org/10.1007/978-3-642-79088-1_5.

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Workman, Paul. "Pharmacological Intervention With Multistep Oncogenesis". In Cancer Chemoprevention, 325–37. Totowa, NJ: Humana Press, 2004. http://dx.doi.org/10.1007/978-1-59259-767-3_22.

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Kasimanickam, Ram. "Pharmacological Intervention of Estrous Cycles". In Bovine Reproduction, 304–13. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118833971.ch33.

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Atti di convegni sul tema "Pharmacological intervention"

Jimeno, Jose M., Gerardo Acosta, Miguel Ángel Molina, Nicky Karachaliou, Cristina Teixidó, Carlos Obiol, Oriol Villacañas et al. "Abstract 4601: Astrocytic elevated gene 1 (AEG1) a target for pharmacological anticancer intervention". In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-4601.

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Vedvyas, Yogindra, Jaclyn McCloskey, Yanping Yang, Irene M. Min e Moonsoo M. Jin. "Abstract 3592: Pharmacological intervention to temporally stimulate or inhibit ICAM-1 targeting CAR-T cells". In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3592.

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Torres-Ayuso, PEDRO, Ewelina Testoni, Natalie L. Stephenson, Anna A. Marusiak, Eleanor W. Trotter, Andrew Hudson, Cassandra L. Hodgkinson, Christopher J. Morrow, Caroline Dive e John Brognard. "Abstract 4408: Mutant ABL1 is a genetic dependency in non-small cell lung cancer amenable to pharmacological intervention". In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4408.

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Navitsky, Michael A., Steven Deutsch e Keefe B. Manning. "A Comparison of Thrombus Susceptibility for Two Pulsatile 50 CC Left Ventricular Assist Pumps". In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80570.

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Approximately 5.7 million Americans are afflicted with heart disease, with a reported 670,000 new cases and 300,000 deaths each year [1]. While the success rate of transplantation procedures continues to improve, organ availability remains limited. Left ventricular assist devices (LVADs) function as a bridge to transplant for advanced staged heart failure patients awaiting a donor heart. The devices have also been used, more recently, as a bridge to recovery by helping to unload the native ventricle. Along with pharmacological intervention, LVADs can act to help reverse pathological hypertrophy and recover normal myocardial function [2].

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Zhou, Yun, Sung-Cheng Huang, Carl K. Hoh, Jun Yang, Timothy F. Cloughsey, Kang-Ping Lin, Magnus Dahlbom, William Graney, J. J. Grous e Keith L. Black. "Image registration and modeling of Ga-68 EDTA for determination of BBB permeability changes induced by pharmacological intervention (RMP7) in tumor patients". In Medical Imaging 1996, a cura di Eric A. Hoffman. SPIE, 1996. http://dx.doi.org/10.1117/12.237867.

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Crawford, Russell. "Learning Gain using a game improve pharmacology knowledge in two transnational HE institutes." In Fifth International Conference on Higher Education Advances. Valencia: Universitat Politècnica València, 2019. http://dx.doi.org/10.4995/head19.2019.9412.

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Gamification in higher education has been shown to provide a diverse range of learning opportunities for higher education practitioners as well as students. Building on our research exploring the benefits of using a card-based, role-playing team game called “BrainceptTM” to aid pharmacology learning for medical students, we now test the reproducibility of our novel finding that this game leads to appreciable and sustained learning gains in medical students from two different higher education institutes. Here we present student feedback, thematic analysis and quantitative pre-and post-test data collected from students who played BrainceptTM. Our data shows that this style of gamified learning has a reproducible positive effect on student pharmacological knowledge as well as measurable learning gains post-game play in both cohorts of students leading us to conclude that gamification of pharmacology learning may be a pedagogically valuable transnational educational intervention.

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Jayanti, Ova, e Rosmawati Lubis. "Murottal Music on Dysmenorrhea Pain Among Students in Madrasah Aliyah Sultan Hasanudin, South Jakarta". In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.05.

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ABSTRACT Background: The incidence of dysmenorrhea is more than 50% among women in every country. In the United States, an average of 60% with the highest prevalence of dysmenorrhea is among adolescent girls, 15% of whom have severe dysmenorrhea. Dysmenorrhea that is not treated properly can interfere with daily activities. Non-pharmacological handling by listening to murottal music can cause the brain to emit theta waves which cause a sense of calm. This study aimed to examine the murottal music on dysmenorrhea pain among students in Madrasah Aliyah Sultan Hasanudin, South Jakarta. Subjects and Method: This was an experimental study with one group pretest-posttest designs. Total of 32 students were enrolled in this study. The dependent variable was dysmenorrhea pain. The independent variable was murottal music. The data were analyzed using Wilcoxon Test. Results: Before the murottal music intervention, 16 students (50%) had mild pain, 12 students (37.5%) felt moderate pain, and 4 students (12.5%) felt severe pain. After the murottal music intervention, 29 out of 32 students felt pain decreased, the intensity felt was in a state of not pain to moderate pain, and it was statistically significant (p<0.001). Conclusion: The murottal music decrease the dysmenorrhea pain among students in Madrasah Aliyah Sultan Hasanudin, South Jakarta. Keywords: adolescents, dysmenorrhea, murottal music Correspondence: Ova Jayanti. Department of Health Sciences, Universitas Nasional Jakarta, Indonesia. DOI: https://doi.org/10.26911/the7thicph.05.05

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Ritschl, Valentin, Ricardo Ferreira, Rúben Fernandes, Eduardo Santos, Kim Fligelstone, Helena Gaspar, Linda Schraven et al. "OP0162 HPR THE NEED FOR PERSONALIZED, NON-PHARMACOLOGICAL INTERVENTION PROGRAMMES IN AUTOIMMUNE CONNECTIVE TISSUE DISORDERS: RESULTS OF A EULAR-FUNDED SCOPING REVIEW WITH A NESTED, DESCRIPTIVE META-ANALYSIS". In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.896.

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Putri, Kurnia Eka, Bhisma Murti e Hanung Prasetya. "The Effectiveness of Acupuncture in Reducing Musculoskeletal Pain: A Meta-Analysis". In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.05.52.

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ABSTRACT Background: Musculoskeletal disorder affects the musculoskeletal system’s function, which includes tendons, bursae, bones, muscles, joints, and ligaments. Acupuncture is one of the non-pharmacological alternative therapies for treating musculoskeletal disorders. This study aimed to examine the effectiveness of acupuncture in reducing pain in musculoskeletal diseases. Subjects and Method: This was a meta-analysis and systematic review. The study was collected articles from PubMed, ProQuest, Science Direct, Scopus, Spinger Link, and Google Scholar databases. The inclusion criteria were full text in English language and used randomized controlled trial study design. There were 8 articles with 466 study subjects comprised in two groups, including 236 people received acupuncture therapy (intervention) and 230 people received sham acupuncture (control). The selected articles were analyzed by ReVman 5.4. Results: This study had high heterogeneity (I2= 90%; p<0.001). This study reported that acupuncture was more effective to reduce musculoskeletal pain than sham acupuncture (Mean Difference= 1.63; 95% CI= 0.89 to 2.38; p= 0.001). Conclusion: Acupuncture is more effective to reduce musculoskeletal pain than sham acupuncture. Keywords: acupuncture, musculoskeletal pain Correspondence: Kurnia Eka Putri. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: nia.putrinia@gmail.com. Mobile: +628995212646. DOI: https://doi.org/10.26911/the7thicph.05.52

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Crhová, Marie, Iva Hrnčiříková, Radka Střeštíková, Klára Šoltés-Mertová, Martin Komzák, Kateřina Kapounková e Anna Ondračková. "Effect of a 3-month Exercise Intervention on Physical Performance, Body Composition, Depression and Autonomic Nervous System in Breast Cancer Survivors: A Pilot Study". In 12th International Conference on Kinanthropology. Brno: Masaryk University Press, 2020. http://dx.doi.org/10.5817/cz.muni.p210-9631-2020-50.

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Purpose: Breast cancer patients are at increased risk of developing comorbidities such as lymphedema, sarcopenia, osteoporosis and cardiovascular disease after breast cancer treatment. These complications contribute to a decrease in quality of life, cardiorespiratory fitness and muscle strength. Regular and long-term physical activity is an effective non-pharmacological strategy that can improve physical, psychological and social outcomes. The aim of our research was to evaluate the effect of various modes of an exercise intervention on physical performance, body composition, depression and autonomic nervous system in breast cancer survivors. Methods: 16 women after surgery with hormonal treatment enter the research. Thirteen of them completed the controlled, quasi-experimental study (54 ± 9 yrs, 164cm ± 6cm, 72 ± 12kg) and were divided into 3 groups according to their place of living: trained under supervision (n=5) (SUPERV), trained at home without supervision by videos (n=7) (HOME) and with no prescribed physical activity (n=4) (CON). Exercise intervention lasted 3 months and comprised of 60 min training units 3 × week (aerobic with resistant exercise in a 2 : 1 mode combined with regular weekly yoga and breathing exercises). The exercise intensity was set individually at 65–75% of HRR based on spiroergometry and was continuously controlled by heart rate monitors. The same principles applied to the HOME group, which, in addition to heart rate monitors, recorded frequency, length, HRmax, HRavg, and Borg scale of intensity perception. VO2max, BMI, fat mass, depression level (Beck’s depression inventory) and the power of the autonomic nervous system (total power and sympatho-vagal balance) were analyzed. For data evaluation we used descriptive statistics and Cohens d effect size. Results: 3 women dropped out of research because of medical reason. In all groups VO2max values increased. The largest increase in VO2max values was in SUPERV group by 36%, in HOME group by 20% and in CON group by 2%. Body weight decreased for groups SUPERV (˗1.2 kg) and CON (-0.1kg), for HOME group there was an increase (+0.2 kg). Body mass index decreased for SUPERV group (-0.4), for HOME and CON it increased (both +0.1). Total power decreased in SUPERV (-0.6) and HOME group (-0.2), in CON has not changed. The same results were achieved by the sympatho-vagal balance, only the CON group increased. Values from Beck’s depression inventory decreased for all groups, most for CON group. Conclusion: A 3-months of supervised and controlled exercise had a significant effect on physical fitness and body composition in comparison with non-supervised home-based physical intervention. Our results indicate that it is strongly advisable to apply a supervised exercise program to induce positive physiological changes in breast cancer survivors as part of aftercare.

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Rapporti di organizzazioni sul tema "Pharmacological intervention"

Hu, Guanyu, Hongshi Zhang, Yufeng Wang e Deyu Cong. Non-pharmacological Intervention for Rehabilitation of Post-Stroke Spasticity: a Protocol for Systematic review and Network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, aprile 2021. http://dx.doi.org/10.37766/inplasy2021.4.0059.

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Geisler, Corinna. A report on ongoing and planned non-pharmacological intervention studies for the treatment and prevention of malnutrition in elderly a MaNuEL report. Universitatsbibliothek Kiel, settembre 2018. http://dx.doi.org/10.21941/manuelworkpackage42.

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The "Malnutrition in the Elderly Knowledge Hub" (MaNuEL) is an action program as part of the Strategic Research Agenda of the Joint Programming Initiative "A Healthy Diet for a Healthy Life". In the MaNuEL project experts of 22 research groups from 7 countries (Austria, France, Germany, Ireland, Spain, the Netherlands and New Zealand) came together to bundle up all the knowledge on malnutrition.

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Xu, Mingmin, Yu Guo, Lu Wang, Yulong Wei, Yue Chen e Jian Yan. Thinking after COVID-19 outbreak：combined treatments versus TCM non-pharmacological intervention, pharmacotherapy for depression: protocol for a systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, agosto 2020. http://dx.doi.org/10.37766/inplasy2020.8.0023.

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Wang, Liaoyao, Yijun Zhan, Yiwen Cai e Jian Pei. Overview of Meta Analyses of Non-pharmacological Interventions for Alzheimer’s Disease. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, luglio 2020. http://dx.doi.org/10.37766/inplasy2020.7.0014.

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Zheng, Jinxuan, Zifeng Li e Xiaojing Zhou. Non Pharmacological and Non-invasive Interventions for Labor: A Network Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, luglio 2020. http://dx.doi.org/10.37766/inplasy2020.7.0081.

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Dy, Sydney M., Arjun Gupta, Julie M. Waldfogel, Ritu Sharma, Allen Zhang, Josephine L. Feliciano, Ramy Sedhom et al. Interventions for Breathlessness in Patients With Advanced Cancer. Agency for Healthcare Research and Quality (AHRQ), novembre 2020. http://dx.doi.org/10.23970/ahrqepccer232.

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Objectives. To assess benefits and harms of nonpharmacological and pharmacological interventions for breathlessness in adults with advanced cancer. Data sources. We searched PubMed®, Embase®, CINAHL®, ISI Web of Science, and the Cochrane Central Register of Controlled Trials through early May 2020. Review methods. We included randomized controlled trials (RCTs) and observational studies with a comparison group evaluating benefits and/or harms, and cohort studies reporting harms. Two reviewers independently screened search results, serially abstracted data, assessed risk of bias, and graded strength of evidence (SOE) for key outcomes: breathlessness, anxiety, health-related quality of life, and exercise capacity. We performed meta-analyses when possible and calculated standardized mean differences (SMDs). Results. We included 48 RCTs and 2 retrospective cohort studies (4,029 patients). The most commonly reported cancer types were lung cancer and mesothelioma. The baseline level of breathlessness varied in severity. Several nonpharmacological interventions were effective for breathlessness, including fans (SMD -2.09 [95% confidence interval (CI) -3.81 to -0.37]) (SOE: moderate), bilevel ventilation (estimated slope difference -0.58 [95% CI -0.92 to -0.23]), acupressure/reflexology, and multicomponent nonpharmacological interventions (behavioral/psychoeducational combined with activity/rehabilitation and integrative medicine). For pharmacological interventions, opioids were not more effective than placebo (SOE: moderate) for improving breathlessness (SMD -0.14 [95% CI -0.47 to 0.18]) or exercise capacity (SOE: moderate); most studies were of exertional breathlessness. Different doses or routes of administration of opioids did not differ in effectiveness for breathlessness (SOE: low). Anxiolytics were not more effective than placebo for breathlessness (SOE: low). Evidence for other pharmacological interventions was limited. Opioids, bilevel ventilation, and activity/rehabilitation interventions had some harms compared to usual care. Conclusions. Some nonpharmacological interventions, including fans, acupressure/reflexology, multicomponent interventions, and bilevel ventilation, were effective for breathlessness in advanced cancer. Evidence did not support opioids or other pharmacological interventions within the limits of the identified studies. More research is needed on when the benefits of opioids may exceed harms for broader, longer term outcomes related to breathlessness in this population.

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Zhou, Dongdong. Non-pharmacological interventions in relapse prevention of unipolar depression: a network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, aprile 2020. http://dx.doi.org/10.37766/inplasy2020.4.0072.

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Cao, Yue, Jie Yuan, Wei Cao e ChuanBiao Wen. Non-pharmacological interventions for Post stroke depression: a protocol for systematic review and network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, dicembre 2020. http://dx.doi.org/10.37766/inplasy2020.12.0051.

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Chen, Wen-zhen, Hong Zhou, Cheng-wei Fu, Yun-zhu Yan, Bo-yu Wu e Jing Wang. Efficacy of non-pharmacological interventions in females with overactive bladder: A Protocol for Systematic Review and Network Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, gennaio 2020. http://dx.doi.org/10.37766/inplasy2021.1.0016.

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Tian, Jidong, Shuo Wu, Lin Dong e Hao Tang. Pharmacological and nonpharmacological interventions for osteoporosis Protocol for an overview with evidence map and a network meta analysis of trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, maggio 2021. http://dx.doi.org/10.37766/inplasy2021.5.0022.

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