Bibliografie tematiche / Plasmodium parasites

Indice

Articoli di riviste
Tesi
Libri
Capitoli di libri
Atti di convegni
Rapporti di organizzazioni

Letteratura scientifica selezionata sul tema "Plasmodium parasites"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 6 settembre 2023

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Consulta la lista di attuali articoli, libri, tesi, atti di convegni e altre fonti scientifiche attinenti al tema "Plasmodium parasites".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Articoli di riviste sul tema "Plasmodium parasites"

HANADA, Kentaro, Toshihide MITAMURA, Masayoshi FUKASAWA, Pamela A. MAGISTRADO, Toshihiro HORII e Masahiro NISHIJIMA. "Neutral sphingomyelinase activity dependent on Mg2+ and anionic phospholipids in the intraerythrocytic malaria parasite Plasmodium falciparum". Biochemical Journal 346, n. 3 (7 marzo 2000): 671–77. http://dx.doi.org/10.1042/bj3460671.

Testo completo

Abstract (sommario):

Sphingolipid metabolism and metabolites are important in various cellular events in eukaryotes. However, little is known about their function in plasmodial parasites. Here we demonstrate that neutral sphingomyelinase (SMase) involved in the sphingomyelin (SM) catabolism is retained by the intraerythrocytic parasite Plasmodium falciparum. When assayed in a neutral pH buffer supplemented with Mg2+ and phosphatidylserine, an activity for the release of the phosphocholine group from SM was detected in parasite-infected, but not in uninfected, erythrocyte ghosts. The SMase activity in the parasite-infected erythrocyte ghosts was enhanced markedly by anionic phospholipids including unsaturated but not saturated phosphatidylserine. Mn2+ could not substitute for Mg2+ to activate SMase in parasite-infected erythrocyte ghosts, whereas both Mn2+ and Mg2+ activated mammalian neutral SMase. The specific activity level of SMase was higher in isolated parasites than in infected erythrocyte ghosts; further fractionation of lysates of the isolated parasites showed that the activity was bound largely to the membrane fraction of the parasites. The plasmodial SMase seemed not to hydrolyse phosphatidylcholine or phosphatidylinositol. The plasmodial SMase, but not SM synthase, was sensitive to scyphostatin, an inhibitor of mammalian neutral SMase, indicating that the plasmodial activities for SM hydrolysis and SM synthesis are mediated by different catalysts. Our finding that the malaria parasites possess SMase activity might explain why the parasites seem to have an SM synthase activity but no activity to synthesize ceramide de novo.

Gli stili APA, Harvard, Vancouver, ISO e altri

Sá e Cunha, Cláudia, Britta Nyboer, Kirsten Heiss, Margarida Sanches-Vaz, Diana Fontinha, Ellen Wiedtke, Dirk Grimm et al. "Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development". Proceedings of the National Academy of Sciences 114, n. 7 (30 gennaio 2017): E1138—E1147. http://dx.doi.org/10.1073/pnas.1606419114.

Testo completo

Abstract (sommario):

The first, obligatory replication phase of malaria parasite infections is characterized by rapid expansion and differentiation of single parasites in liver cells, resulting in the formation and release of thousands of invasive merozoites into the bloodstream. Hepatic Plasmodium development occurs inside a specialized membranous compartment termed the parasitophorous vacuole (PV). Here, we show that, during the parasite’s hepatic replication, the C-terminal region of the parasitic PV membrane protein exported protein 1 (EXP-1) binds to host Apolipoprotein H (ApoH) and that this molecular interaction plays a pivotal role for successful Plasmodium liver-stage development. Expression of a truncated EXP-1 protein, missing the specific ApoH interaction site, or down-regulation of ApoH expression in either hepatic cells or mouse livers by RNA interference resulted in impaired intrahepatic development. Furthermore, infection of mice with sporozoites expressing a truncated version of EXP-1 resulted in both a significant reduction of liver burden and delayed blood-stage patency, leading to a disease outcome different from that generally induced by infection with wild-type parasites. This study identifies a host–parasite protein interaction during the hepatic stage of infection by Plasmodium parasites. The identification of such vital interactions may hold potential toward the development of novel malaria prevention strategies.

Gli stili APA, Harvard, Vancouver, ISO e altri

Kalanon, Ming, e Geoffrey I. McFadden. "Malaria, Plasmodium falciparum and its apicoplast". Biochemical Society Transactions 38, n. 3 (24 maggio 2010): 775–82. http://dx.doi.org/10.1042/bst0380775.

Testo completo

Abstract (sommario):

Malaria, which is caused by species of the parasite genus Plasmodium, remains a major global health problem. A vestigial plastid homologous with the chloroplasts of plants and algae was discovered in malaria and related parasites from the phylum Apicomplexa and has radically changed our view of the evolutionary origins of these disease-causing protists. We now recognize that this large group of parasites had a photosynthetic ancestry and were converted into parasitism early in the evolution of animals. Apicomplexans have probably been parasitizing the animal kingdom for more than 500 million years. The relic plastid persists in most apicomplexans and is an essential component. Perturbation of apicoplast function or inheritance results in parasite death, making the organelle a promising target for chemotherapy. Plastids, including those of malaria parasites, are essentially reduced endosymbiotic bacteria living inside a eukaryotic host. This means that plastids have bacterial-type metabolic pathways and housekeeping processes, all of which are vulnerable to antibacterial compounds. Indeed, many antibacterials kill malaria parasites by blocking essential processes in the plastid. Furthermore, a range of herbicides that target plastid metabolism of undesired plants are also parasiticidal, making them potential new leads for antimalarial drugs. In the present review, we examine the evolutionary origins of the malaria parasite's plastid by endosymbiosis and outline the recent findings on how the organelle imports nuclear-encoded proteins through a set of translocation machineries in the membranes that bound the organelle.

Gli stili APA, Harvard, Vancouver, ISO e altri

Tewari, Rita, Solabomi A. Ogun, Ruwani S. Gunaratne, Andrea Crisanti e Anthony A. Holder. "Disruption of Plasmodium berghei merozoite surface protein 7 gene modulates parasite growth in vivo". Blood 105, n. 1 (1 gennaio 2005): 394–96. http://dx.doi.org/10.1182/blood-2004-06-2106.

Testo completo

Abstract (sommario):

Abstract Merozoite invasion of red blood cells is crucial to the development of the parasite that causes malaria. Merozoite surface proteins (MSPs) mediate the first interaction between parasite and erythrocyte. In Plasmodium falciparum, they include a complex of products from at least 3 genes (msp1, msp6, and msp7), one of which, msp7, is part of a gene family containing 3 and 6 adjacent members in Plasmodium yoelii and Plasmodium falciparum, respectively. We have identified and disrupted msp7 in the Plasmodium berghei gene family. The protein is expressed in schizonts and colocalizes with MSP1. The synthesis and processing of MSP1 was unaffected in the parasite with the disrupted gene (MSP7ko). Disruption of msp7 was not lethal but affected blood-stage parasite growth. MSP7ko parasites initially grew more slowly than wild-type parasites. However, when reticulocytes were prevalent, the rate of increase in parasitemia was similar, suggesting that MSP7ko parasites prefer to invade and grow within reticulocytes. (Blood. 2005;105:394-396)

Gli stili APA, Harvard, Vancouver, ISO e altri

Morgan, D. M. L., U. Bachrach, Y. G. Assaraf, E. Harari e J. Golenser. "The effect of purified aminoaldehydes produced by polyamine oxidation on the development in vitro of Plasmodium falciparum in normal and glucose-6-phosphate-dehydrogenase-deficient erythrocytes". Biochemical Journal 236, n. 1 (15 maggio 1986): 97–101. http://dx.doi.org/10.1042/bj2360097.

Testo completo

Abstract (sommario):

Purified aminoaldehydes produced by polyamine oxidation were toxic to the malarial parasite, Plasmodium falciparum, cultured in human erythrocytes. There was a profound effect on young ring forms, and, during maturation, parasites became more sensitive to the aldehydes. Oxidation of the aldehydes abolished the lethal effect. The plasmodia within glucose-6-phosphate-dehydrogenase (G6PD)-deficient erythrocytes were more sensitive to mono- and di-aldehydes than were parasites in normal erythrocytes. G6PD-deficient erythrocytes were also more sensitive to pretreatment with the dialdehyde produced by the oxidation of spermine. Pretreatment prevented further invasion by the parasites.

Gli stili APA, Harvard, Vancouver, ISO e altri

Gutiérrez-López, Rafael, Josué Martínez-de la Puente, Laura Gangoso, Ramón Soriguer e Jordi Figuerola. "Plasmodium transmission differs between mosquito species and parasite lineages". Parasitology 147, n. 4 (22 gennaio 2020): 441–47. http://dx.doi.org/10.1017/s0031182020000062.

Testo completo

Abstract (sommario):

AbstractFactors such as the particular combination of parasite–mosquito species, their co-evolutionary history and the host's parasite load greatly affect parasite transmission. However, the importance of these factors in the epidemiology of mosquito-borne parasites, such as avian malaria parasites, is largely unknown. Here, we assessed the competence of two mosquito species [Culex pipiens and Aedes (Ochlerotatus) caspius], for the transmission of four avian Plasmodium lineages (Plasmodium relictum SGS1 and GRW11 and Plasmodium cathemerium-related lineages COLL1 and PADOM01) naturally infecting wild house sparrows. We assessed the effects of parasite identity and parasite load on Plasmodium transmission risk through its effects on the transmission rate and mosquito survival. We found that Cx. pipiens was able to transmit the four Plasmodium lineages, while Ae. caspius was unable to transmit any of them. However, Cx. pipiens mosquitoes fed on birds infected by P. relictum showed a lower survival and transmission rate than those fed on birds infected by parasites related to P. cathemerium. Non-significant associations were found with the host–parasite load. Our results confirm the existence of inter- and intra-specific differences in the ability of Plasmodium lineages to develop in mosquito species and their effects on the survival of mosquitoes that result in important differences in the transmission risk of the different avian malaria parasite lineages studied.

Gli stili APA, Harvard, Vancouver, ISO e altri

Mirzaei, Farzaneh, Abolghasem Siyadatpanah, Roghayeh Norouzi, Soheila Pournasir, Veeranoot Nissapatorn e Maria de Lourdes Pereira. "Blood Parasites in Domestic Birds in Central Iran". Veterinary Sciences 7, n. 3 (4 settembre 2020): 126. http://dx.doi.org/10.3390/vetsci7030126.

Testo completo

Abstract (sommario):

Parasites may affect the dynamics of bird populations. Plasmodium, Leucocytozoon and Haemoproteus are well-known avian haematozoa that can trigger decreased productivity and high mortality in domesticated birds. In this study, we evaluated the prevalence of avian blood parasites (Plasmodium, Leucocytozoon and Haemoproteus) against 335 birds of 8 species in the Yazd province in central Iran. To detect blood parasites, Giemsa-stained blood smears were prepared. Of the birds, 11.64% (39/335) were infected with at least one parasite genus, particularly Haemoproteus (32.6%; 23/335). The total prevalence values for Plasmodium, Haemoproteus and Leucocytozoon were 1.7, 6.8 and 2.9%, respectively. Plasmodium had lower prevalence rates of 1.7% (6/335). Among birds, pigeons, hens and ducks have the highest prevalence of Haemoproteus, Leucocytozoon and Plasmodium parasites at 1.7%, 6.8% and 2.9%, respectively. Results from this research extend our knowledge on the incidence of avian blood parasites in domesticated birds living in central Iran. The overall low incidence of avian blood parasites in birds was found in the Yazd province, Iran.

Gli stili APA, Harvard, Vancouver, ISO e altri

Tebben, Kieran, Salif Yirampo, Drissa Coulibaly, Abdoulaye K. Koné, Matthew B. Laurens, Emily M. Stucke, Ahmadou Dembélé et al. "Malian children infected with Plasmodium ovale and Plasmodium falciparum display very similar gene expression profiles". PLOS Neglected Tropical Diseases 17, n. 1 (25 gennaio 2023): e0010802. http://dx.doi.org/10.1371/journal.pntd.0010802.

Testo completo

Abstract (sommario):

Plasmodium parasites caused 241 million cases of malaria and over 600,000 deaths in 2020. Both P. falciparum and P. ovale are endemic to Mali and cause clinical malaria, with P. falciparum infections typically being more severe. Here, we sequenced RNA from nine pediatric blood samples collected during infections with either P. falciparum or P. ovale, and characterized the host and parasite gene expression profiles. We found that human gene expression varies more between individuals than according to the parasite species causing the infection, while parasite gene expression profiles cluster by species. Additionally, we characterized DNA polymorphisms of the parasites directly from the RNA-seq reads and found comparable levels of genetic diversity in both species, despite dramatic differences in prevalence. Our results provide unique insights into host-pathogen interactions during malaria infections and their variations according to the infecting Plasmodium species, which will be critical to develop better elimination strategies against all human Plasmodium parasites.

Gli stili APA, Harvard, Vancouver, ISO e altri

Matz, Joachim M., Alyssa Ingmundson, Jean Costa Nunes, Werner Stenzel, Kai Matuschewski e Taco W. A. Kooij. "In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence". Eukaryotic Cell 14, n. 6 (27 marzo 2015): 528–34. http://dx.doi.org/10.1128/ec.00276-14.

Testo completo

Abstract (sommario):

ABSTRACT Malaria pathology is linked to remodeling of red blood cells by eukaryotic Plasmodium parasites. Central to host cell refurbishment is the trafficking of parasite-encoded virulence factors through the Plasmodium translocon of exported proteins (PTEX). Much of our understanding of its function is based on experimental work with cultured Plasmodium falciparum , yet direct consequences of PTEX impairment during an infection remain poorly defined. Using the murine malaria model parasite Plasmodium berghei , it is shown here that efficient sequestration to the pulmonary, adipose, and brain tissue vasculature is dependent on the PTEX components thioredoxin 2 (TRX2) and PTEX88. While TRX2 -deficient parasites remain virulent, PTEX88 -deficient parasites no longer sequester in the brain, correlating with abolishment of cerebral complications in infected mice. However, an apparent trade-off for virulence attenuation was spleen enlargement, which correlates with a strongly reduced schizont-to-ring-stage transition. Strikingly, general protein export is unaffected in PTEX88 -deficient mutants that mature normally in vitro . Thus, PTEX88 is pivotal for tissue sequestration in vivo , parasite virulence, and preventing exacerbation of spleen pathology, but these functions do not correlate with general protein export to the host erythrocyte. The presented data suggest that the protein export machinery of Plasmodium parasites and their underlying mechanistic features are considerably more complex than previously anticipated and indicate challenges for targeted intervention strategies.

Gli stili APA, Harvard, Vancouver, ISO e altri

Kassim, Yasmin M., Feng Yang, Hang Yu, Richard J. Maude e Stefan Jaeger. "Diagnosing Malaria Patients with Plasmodium falciparum and vivax Using Deep Learning for Thick Smear Images". Diagnostics 11, n. 11 (27 ottobre 2021): 1994. http://dx.doi.org/10.3390/diagnostics11111994.

Testo completo

Abstract (sommario):

We propose a new framework, PlasmodiumVF-Net, to analyze thick smear microscopy images for a malaria diagnosis on both image and patient-level. Our framework detects whether a patient is infected, and in case of a malarial infection, reports whether the patient is infected by Plasmodium falciparum or Plasmodium vivax. PlasmodiumVF-Net first detects candidates for Plasmodium parasites using a Mask Regional-Convolutional Neural Network (Mask R-CNN), filters out false positives using a ResNet50 classifier, and then follows a new approach to recognize parasite species based on a score obtained from the number of detected patches and their aggregated probabilities for all of the patient images. Reporting a patient-level decision is highly challenging, and therefore reported less often in the literature, due to the small size of detected parasites, the similarity to staining artifacts, the similarity of species in different development stages, and illumination or color variations on patient-level. We use a manually annotated dataset consisting of 350 patients, with about 6000 images, which we make publicly available together with this manuscript. Our framework achieves an overall accuracy above 90% on image and patient-level.

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Tesi sul tema "Plasmodium parasites"

Enweji, Nizar. "Dynamics of Resistant Plasmodium falciparum Parasites". Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230224.

Testo completo

Abstract (sommario):

Persistence of drug resistant Plasmodium falciparum is a major problem to management and control malaria in endemic areas. The focus of this thesis was to study the dynamics of resistant P. falciparum parasites. The study was performed in two African countries: 1) Sudan: Asar village in eastern Sudan, here we examined the persistence of drug sensitive and resistant P. falciparum genotypes among individuals with single-clone and multiple clones infection during the dry season. We genotyped microsatellite loci in the vicinity of the dihydrofolate reductase gene (dhfr) and the dihydropteroate synthase gene (dhps). Microsatellite investigation showed that asymptomatic parasitemia persisted in some patients for several months throughout the dry season and into the next transmission season. In some samples mixed infections were detected, and we noted several cases where the microsatellite haplotype varied from month to month, suggesting turnover of different parasite populations in the blood. This demonstrates that even during asymptomatic infections there can be dynamics within the parasite population in an individual. In addition, we calculated the parasite density throughout the dry season to the next transmission season by using allele-specific quantitative PCR. Parasite density during the dry season fluctuated, but was generally lower than in the first transmission season. A significant difference (P<0.05) between dry and first transmission season was found in regard to the parasite density, whereas no significant difference was observed when dry and second transmission season were compared (P>0.05). 2) Ethiopia: West Arsi zone, one of the malaria endemic zones of the Oromia region. In the first study we determined the prevalence of asymptomatic malaria carriages from November-December 2012. According to PCR the prevalence of sub-microscopic P. falciparum carriage was 19.2%, microscopy-based prevalence was 3.7% while the prevalence was 6.9% using RDT. Based on this, PCR was considered a better tool for measuring Plasmodium prevalence than microscopy and RDT. A second study addressed the genetic diversity of chloroquine resistance (CQR) in P. falciparum by analysing four microsatellite markers in and around the pfcrt gene. Although CQ was withdrawn for more than a decade, 100% of the parasites still carried the Pfcrt K76T mutation. Only the CVIET haplotype was identified. Based on combinations of MS markers, seven different Ethiopian CQR variants (E1-E7) were identified. Both intronic and MS flanking the pfcrt gene showed low levels of diversity.

Gli stili APA, Harvard, Vancouver, ISO e altri

Raja, Amber Iftikhar. "Characterisation of a Chemically Attenuated Blood-Stage Malaria Vaccine for the Rodent Parasite, Plasmodium yoelii". Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366436.

Testo completo

Abstract (sommario):

The development of a vaccine is essential for the elimination and eventual eradication of malaria. However, despite many years of effort, a successful malaria vaccine has not yet been achieved. Many of the subunit vaccine candidates tested in clinical trials have provided limited efficacy; therefore, efforts to develop an effective vaccine against malaria need to continue. The development of a whole parasite blood-stage vaccine would maximise the number of blood-stage antigens presented to the immune system, including conserved parasite antigens. Chemical treatment has been used to develop attenuated whole organism vaccines against pathogens, such as viruses. A blood-stage vaccine approach using DNA- binding drugs to chemically attenuate Plasmodium parasites was first demonstrated using ring stage Plasmodium chabaudi parasites in mice. However, it was not clear whether this approach would apply to other parasites and as such have potential for translation to human malaria species. We have thus tested the use of these drugs as attenuating agents for another blood-stage Plasmodium spp., Plasmodium yoelii.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Institute for Glycomics
Science, Environment, Engineering and Technology
Full Text

Gli stili APA, Harvard, Vancouver, ISO e altri

Chappell, Lia Victoria Louise. "Novel approaches for transcriptome analysis in Plasmodium parasites". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648817.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Hogg, Jonathan C. "Effects of Plasmodium infection on anopheline mosquito fecundity". Thesis, Keele University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261487.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Porter, Heidi S. "The effect of febrile temperature on Plasmodium falciparum /". Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd2225.pdf.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Tay, Chwen Ling. "The targets and role of palmitoylation in Plasmodium parasites". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648641.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Engel, Jessica Alexandra. "Investigating Plasmodium falciparum Histone Deacetylase 1 Complex Proteins". Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367801.

Testo completo

Abstract (sommario):

Malaria causes substantial morbidity and mortality worldwide. Although there has been a considerable decline in global malaria incidence and mortality rates since 2000, it is estimated that more than 400,000 deaths occurred in 2015 as a result of this parasitic disease. The lack of a broadly effective licensed vaccine and the threat of malaria parasite resistance to current drugs means there is an urgent need for the development of new therapies with novel parasite targets. With a renewed call for global malaria eradication, novel therapeutic strategies are crucial to continue progress achieved over the last decade in combating malaria and to achieving a malaria-free world. Targeting epigenetic mechanisms within Plasmodium parasites represents a promising therapeutic approach for malaria. Histone deacetylase (HDAC) enzymes, the focus of this thesis, act in conjunction with histone acetyltransferases (HATs) to reversibly acetylate histone and non-histone proteins. Some HDACs, in particular class I and II HDACs, are already validated drug targets for cancer therapy and are showing promise as antimalarial drug targets. However, besides their classical role in regulating gene expression, knowledge of the roles that HDACs play in the Plasmodium parasites, is limited. Like higher eukaryotic HDACs, P. falciparum HDACs (PfHDACs) are believed to localise in multi-protein complexes with accessory proteins and to regulate lysine acetylation of both histones and non-histone proteins.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text

Gli stili APA, Harvard, Vancouver, ISO e altri

Lyons, E. J. "Diversity, structure and population genetics of the human malaria parasites Plasmodium falciparum and Plasmodium vivax". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270206.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Silva, Mafalda Lopes da. "Dissecting the molecular interaction between hepatocytes and Plasmodium liver parasites". Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/8572.

Testo completo

Abstract (sommario):

Dissertation presented to obtain the Ph.D degree in Biology
Malaria is one of the world´s leading causes of death, responsible for over 700,000 deaths per year, the majority of which are African children under 5 years of age. Malaria disease is caused by the transmission of an Apicomplexa parasite, Plasmodium, through the bit of a female Anopheles mosquito, and transmitted parasites quickly reach the mammalian host liver, where the first round of replication begins. Plasmodium sporozoites, once inside the liver, must invade and survive within hepatocytes until the first replicative stage within the mammalian host is accomplished. Upon migration through various cells, sporozoites are able to actively enter hepatocytes, forming a Parasitophorous Vacuole Membrane (PVM) around itself. Once this intracellular niche is established, parasite replication and growth is initiated. Dramatic morphological as well as gene expression modifications occur at this stage, and the parasite achieves one of the highest replication rates known within eukaryotic species (Sinnis and Sim, 1997). Although the Plasmodium life-cycle has been extensively characterized, relatively little is known about sporozoite interaction with host organelles, vesicles and proteins. To address this issue, Plasmodium interactions with the host cell endomembranes was analyzed at various stages of liver infection using indirect immunofluorescence. Plasmodium parasites were seen closely associated with host endoplasmic reticulum (ER) and the Golgi apparatus. Surprisingly, late endosomes/lysosomes, observed with the membrane markers Rab7a, CD63 and LAMP1, aggregated around the parasite. No interaction with host peroxisomes, early and recycling endosomes was observed.(...)
Financial support was provided by Fundação para a Ciência e Tecnologia. Portugal, through the Ph.D. fellowship grant SFRH/BD/27705/2006.

Gli stili APA, Harvard, Vancouver, ISO e altri

Ben, Abderrazak Souha. "Variabilité génétique des populations de "Plasmodium falciparum"". Montpellier 2, 1993. http://www.theses.fr/1993MON20013.

Testo completo

Abstract (sommario):

Nous avons analyse par electrophorese d'isoenzymes (7 a 12 loci) le polymorphisme genetique de 5 populations (113 stocks) du plasmodium falciparum, l'agent de la forme la plus severe de paludisme. Les resultats ont ete interpretes en termes de genetique des populations, dans le but d'analyser la structure des populations naturelles de ce parasite. Un fort desequilibre de liaison apparait dans trois des populations etudiees, ainsi que dans l'echantillon global. Une quatrieme population montre egalement des indices de desequilibre, quoique dans une moindre mesure. Une seule serie n'a montre aucune deviation par rapport aux predictions de la panmixie. Ces resultats ne sont explicables, ni par la structuration geographique des populations, ni par la selection naturelle. L'hypothese la plus parcimonieuse pour rendre compte de nos donnees est l'existence d'une propagation uniparentale chez p. Falciparum dans certaines circonstances. De forts indices d'autofecondation peuvent expliquer ce resultat. La structure des populations naturelles de plasmodium falciparum et le mode de reproduction du parasite ont des consequences importantes sur l'epidemiologie de la maladie. Le modele subclonal ou partiellement clonal que nous proposons ici est radicalement different, quant a ses implications taxonomiques et epidemiologiques, du modele potentiellement panmictique qui avait ete propose pour p. Falciparum. En effet, si des lignees parasitaires subissent une propagation uniparentale, elles se comportent comme des clones, et gardent intactes leurs caracteristiques genetiques d'une generation a l'autre, tandis que le patrimoine genetique de chaque genotype fait l'objet d'un brassage energique a chaque generation dans le cas du modele potentiellement panmictique. Les problemes poses sont: (a) la nature du processus de reproduction uniparentale; (b) l'importance respective des cycles sexues et asexues; (c) la stabilite dans l'espace et dans le temps des lignees uniparentales

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Libri sul tema "Plasmodium parasites"

author, Blake John G., Loiselle Bette A. author, Penrose Amanda S. author, Parker Patricia G. author e Ricklefs Robert E. author, a cura di. Diversity, prevalence, and host specificity of avian Plasmodium and Haemoproteus in a Western Amazon assemblage. Washington, D.C: American Ornithologists' Union, 2013.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

P, Waters Andrew, e Janse Chris J, a cura di. Malaria parasites, genomes and molecular biology. Wymondham, Norfolk, England: Caister Academic Press, 2004.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Malaria parasites: Comparative genomics, evolution and molecular biology. Norfolk, UK: Caister Academic Press, 2013.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Garnham, P. C. C. Catalogue of the Garnham collection of malaria parasites and other haemosporidia. Cambridge: Cambridge University Press, 1986.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Garnham, P. C. C. Catalogue of the Garnham Collection of malaria parasites and other haemosporidia. Cambridge: Cambridge University Press London, 1988.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Garnham, P. C. C. Catalogue of the Garnham Collection of malaria parasites and other haemosporidia. [London: The Wellcome Trust, 1986.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Vladimirovna, Beĭer Tamara, Lysenko A. I͡A︡ e Vsesoi͡u︡znoe obshchestvo protozoologov, a cura di. Mali͡a︡riĭnye parazity mlekopitai͡u︡shchikh. Leningrad: Izd-vo "Nauka," Leningradskoe otd-nie, 1986.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Iqbal, M. P. Investigation of the TFIIB and fibrillarin genes in the human malaria parasite plasmodium falciparum. Manchester: UMIST, 1996.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

C, Frontali, a cura di. Molecular events in Plasmodium life cycle and factors affecting mosquito/parasite relationships: EEC symposium held at the Istituto superiore di sanità, Rome, October 30-November 1, 1986 : proceedings. Roma: Istituto superiore di sanità, 1987.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

1941-, Eaton John Wallace, Meshnick Steven R e Brewer George J. 1930-, a cura di. Malaria and the red cell 2: Proceedings of the Second Workshop on Malaria and the Red Cell, held in Ann Arbor, Michigan, October 24, 1988. New York: A.R. Liss, 1989.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Capitoli di libri sul tema "Plasmodium parasites"

Mir, Snober S., Subir Biswas e Saman Habib. "Targeting Apicoplast Pathways in Plasmodium". In Apicomplexan Parasites, 163–86. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633883.ch9.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Prasad, G. Sridhar, Nicholas D. P. Cosford e Sailen Barik. "Plasmodium Hsp90 as an Antimalarial Target". In Apicomplexan Parasites, 431–51. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633883.ch23.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Lee, Kim-Sung, e Indra Vythilingam. "Plasmodium knowlesi: Emergent Human Malaria in Southeast Asia". In Parasites and their vectors, 5–31. Vienna: Springer Vienna, 2013. http://dx.doi.org/10.1007/978-3-7091-1553-4_2.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Davioud-Charvet, Elisabeth, e Don Antoine Lanfranchi. "Subversive Substrates of Glutathione Reductases from Plasmodium falciparum-Infected Red Blood Cells as Antimalarial Agents". In Apicomplexan Parasites, 373–96. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633883.ch20.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Sanchez, Cecilia P., Judith Pfahler, Hernando A. del Portillo e Michael Lanzer. "Transient Transfection of Plasmodium vivax Blood-Stage Parasites". In Methods in Molecular Biology, 151–59. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-026-7_10.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Cui, Liwang, Namtip Trongnipatt, Jetsumon Sattabongkot e Rachanee Udomsangpetch. "Culture of Exoerythrocytic Stages of the Malaria Parasites Plasmodium falciparum and Plasmodium vivax". In Host-Pathogen Interactions, 263–73. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-204-5_18.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Bozdech, Zbynek, Sachel Mok e Archna P. Gupta. "DNA Microarray-Based Genome-Wide Analyses of Plasmodium Parasites". In Methods in Molecular Biology, 189–211. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-026-7_13.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Ward, Martin, e Giovanni Benelli. "Mosquitoes, Plasmodium Parasites, and Cancer: Where from, Where to?" In Parasitology Research Monographs, 323–50. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-94075-5_14.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Frimpong, Augustina, Frederica Dedo Partey e Michael Fokuo Ofori. "Identification and Enumeration of Plasmodium falciparum Parasites by Light Microscopy". In Methods in Molecular Biology, 3–10. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2189-9_1.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Mohapatra, Alok Das, Jenna Zuromski e Jonathan Kurtis. "Assessing PfGARP-Mediated Apoptosis of Blood-Stage Plasmodium falciparum Parasites". In Methods in Molecular Biology, 659–72. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2189-9_49.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Atti di convegni sul tema "Plasmodium parasites"

Nugroho, Hanung Adi, A. Fatan D. Marsiano, Khampaserth Xaphakdy, Phounsiri Sihakhom, Eka Legya Frannita, Rizki Nurfauzi e E. Elsa Herdiana Murhandarwati. "Multithresholding Approach for Segmenting Plasmodium Parasites". In 2019 11th International Conference on Information Technology and Electrical Engineering (ICITEE). IEEE, 2019. http://dx.doi.org/10.1109/iciteed.2019.8929995.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Nugroho, Hanung Adi, Julisa Bana Abraham, Aina Hubby Azzira, Eka Legya Frannita, Rizki Nurfauzi, Faza Maula Azif e E. Elsa Herdiana Murhandarwati. "Performance of Convolutional Neural Network in Detecting Plasmodium Parasites". In 2019 IEEE 9th International Conference on System Engineering and Technology (ICSET). IEEE, 2019. http://dx.doi.org/10.1109/icsengt.2019.8906303.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Kehrer, Jessica. "Clearing of hemozoin in Plasmodium parasites enables STED Nanoscopy". In European Microscopy Congress 2020. Royal Microscopical Society, 2021. http://dx.doi.org/10.22443/rms.emc2020.703.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Prananda, Alifia Revan, Hanung Adi Nugroho e Igi Ardiyanto. "Enumeration of Plasmodium Parasites on Thin Blood Smear Digital Microscopic Images". In 2019 5th International Conference on Science in Information Technology (ICSITech). IEEE, 2019. http://dx.doi.org/10.1109/icsitech46713.2019.8987492.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Aladago, Maxwell Mbailla, Lorenzo Torresani e Elena V. Rosca. "Semantic Segmentation of the Growth Stages of Plasmodium Parasites using Convolutional Neural Networks". In 2019 IEEE AFRICON. IEEE, 2019. http://dx.doi.org/10.1109/africon46755.2019.9133937.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Luther, Ed, e Howard M. Shapiro. "Use of DNA base pair composition for the specefic identification of malaria parasites (plasmodium)". In 2014 40th Annual Northeast Bioengineering Conference (NEBEC). IEEE, 2014. http://dx.doi.org/10.1109/nebec.2014.6972861.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Coma-Cros, Elisabet Martí, Christian Grandfils, Chantal Sevrin, Jos Paulusse, Naomi Hamelmann, Inga Siden-Kiamos, John Vontas et al. "Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of Drugs against Plasmodium Parasites". In The 4th World Congress on Recent Advances in Nanotechnology. Avestia Publishing, 2019. http://dx.doi.org/10.11159/nddte19.106.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

"Prevalence of Hepatitis B virus and Haemoparasites among Apparently Healthy Individuals in College of Health Sciences Ladoke Akinola University of Technology Ogbomoso". In International Conference on Public Health and Humanitarian Action. International Federation of Medical Students' Associations - Jordan, 2022. http://dx.doi.org/10.56950/fynm6569.

Testo completo

Abstract (sommario):

Hepatitis B virus (HBV) infection, a viral disease, is of great concern to health community due to its adverse effects on the liver of infected individuals. Haemoparasites are blood-dwelling parasites whose effects span from mild to severe infections. This study focused on Plasmodium falciparum Trypanosoma brucei gambiense and microfilaria which causes malaria, sleeping sickness and microfilaramia in humans respectively. This is a retrospective study that was designed to determine the prevalence of hepatitis B infection and haemoparasistes among apparently healthy individuals in the College of Health Sciences, Ladoke Akintola University of technology, Ogbomoso. Paucity of data regarding prevalence of HBV and haemoparasites among apparently healthy individuals in Ogbomoso necessitated this study. A total number of one hundred and fifty five (155) blood samples were collected within 3months for this study. Out of the one hundred and fifty five (155) blood samples collected, ten (10) tested positive to HBsAg giving a prevalence rate of 6.5%. The samples were also examined for haemoparasites on thin and thick blood smears stained with Giemsa dye using oil immersion (100X) objective of the light microscope. Only one type of haemoparasite was detected: malaria parasite with a prevalence of 87.1%. Prevalence rate for HBV and malaria parasite with respect to age group was found to be higher in age group of 25-30 and in term of sex, males have higher prevalence rate than females. The prevalence of 7.4% for co-infection of HBV and malaria parasite within the study population confirmed the high endemicity of both infections in the studied area being an urban area. It could be recommended that the Nigerian government HBV vaccination program should be extended to the adult population and not just limited to the national childhood immunization program. This is important because none of the subjects that participated in the study were vaccinated.

Gli stili APA, Harvard, Vancouver, ISO e altri

Safarianti, Aty Widyawaruyanti, Hilkatul Ilmi, Achmad Fuad, Indah Tantular e Maryatun. "In Vitro Effect of 96% Ethanol Extract of Bitter Herbs (Andrographis paniculata Nees) on Heme Detoxification Process of Plasmodium falciparum Parasites". In The 2nd Syiah Kuala International Conference on Medicine and Health Sciences. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0008791100720075.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Silva, Saulo Brivaldo Mendonça da, Ana Bárbara Xavier da Silva, Mariana Souza Bezerra Cavalcanti, João Lucas Pessoa de Vasconcelos, Maria Clara Cavalcante Gomes e Nathaly Bruna de Oliveira Silva. "A PROTEÍNA PfGARP COMO POSSÍVEL CANDIDATA À VACINA ANTIMALÁRICA". In XXVII Semana de Biomedicina Inovação e Ciência. Editora IME, 2021. http://dx.doi.org/10.51161/9786588884119/28.

Testo completo

Abstract (sommario):

Introdução: A malária é uma parasitose que, apesar de antiga, continua sendo um grande risco para saúde pública com cerca de 445 mil mortes por ano ao redor do mundo(2). Apesar de possuir cinco agentes etiológicos, o Plasmodium falciparum é o principal, sendo responsável pelo maior número de mortes por malária(1,2). Uma vez que há diversos empecilhos quando se trata da erradicação da malária como resistência a inseticidas e a drogas antimaláricas, foi observada a necessidade de uma vacina contra o agravamento dessa parasitose(1). O fato de que a fase sanguínea do Plasmodium é atualmente apontada como um dos possíveis alvos para a ação de uma vacina, fez os pesquisadores enxergarem a proteína rica em ácido glutâmico do P. falciparum (PfGARP) que é encontrada na superfície das células vermelhas infectadas pelo parasita(2,3). Assim, fez-se necessária uma pesquisa com os anticorpos contra essa proteína para melhor elucidação. Objetivos: O objetivo deste resumo é observar os efeitos dos anticorpos anti-PfGARP contra trofozoítos do Plasmodium falciparum e como esses anticorpos oferecem proteção contra o agravamento da malária. Métodos: Foi realizada a procura nas plataformas científicas PubMed e Google Acadêmico e os artigos utilizados foram encontrados por meio do descritor “malaria vaccine”. Resultados: Os anticorpos anti-PfGARP presentes nos indivíduos estudados foram apontados como responsáveis pela diminuição da integridade morfológica dos parasitas, onde os mesmos apresentaram-se picnóticos, característicos de morte(3). Além disso, esses anticorpos causaram uma diminuição da integridade do vacúolo digestivo, apresentando-se com um tamanho menor ou até mesmo ausente(3). Outrossim, os parasitas sofreram alterações no potencial de membrana mitocondrial, tendo a mitocôndria perdido função após 24h(3). Por fim, os anticorpos anti-PfGARP ativaram a morte celular programada desses parasitas por meio da ativação de caspases(3). Conclusões: Com base no que foi exposto, é possível concluir que a PfGARP é uma excelente candidata para o desenvolvimento de uma vacina contra o Plasmodium falciparum por meio da morte dos parasitas. Sendo assim, é necessário que sejam realizados mais estudos com a PfGARP com o objetivo de obter mais informações acerca dos benefícios de uma vacina com essa proteína e, ainda, conhecer possíveis malefícios para que possa ser inclusa no mercado de forma eficaz e segura, diminuindo a ocorrência de malária grave e assim evitando o sofrimento de milhares de pessoas infectadas com esta parasitose ao redor do mundo.

Gli stili APA, Harvard, Vancouver, ISO e altri

Rapporti di organizzazioni sul tema "Plasmodium parasites"

Piper, Robert C. Parasite Lactate Dehydrogenase for Diagnosis of Plasmodium Falciparum. Phase II. Fort Belvoir, VA: Defense Technical Information Center, aprile 1997. http://dx.doi.org/10.21236/adb230017.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Prachumsri, Jetsumon. Proteomic Study of Human Malaria Parasite Plasmodium Vivax Liver Stages for Development of Vaccines and Drugs. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2008. http://dx.doi.org/10.21236/ada494445.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

McElwain, Terry, Eugene Pipano, Guy Palmer, Varda Shkap, Stephen Hines e Douglas Jasmer. Protection of Cattle Against Babesiosis: Immunization with Recombinant DNA Derived Apical Complex Antigens of Babesia bovis. United States Department of Agriculture, giugno 1995. http://dx.doi.org/10.32747/1995.7612835.bard.

Testo completo

Abstract (sommario):

Bovine babesiosis caused by Babesia bovis continues to be a significant deterrent to global livestock production. Current control methods have both biological and technical drawbacks that have stimulated research on improved methods of vaccination. This BARD project has focused on characterization of candidate Babesia bovis vaccine antigens located in the apical complex, a unique group of subcellular organelles - including rhoptries, micronemes, and spherical bodies - involved in the invation of erythrocytes. Spherical bodies and rhoptries were partially purified and their contents characterized using monoclonal antibodies. Existing and newly developed monoclonal antibodies bound to antigens in the spherical body, rhoptry, merozoite membrane, and infected erythrocyte membrane. In an initial immunization study using biologically cloned strains, it was demonstrated that strain-common epitopes are important for inducing immune protection against heterologous challenge. Rhoptry-associated antigen 1 (RAP-1) had been demonstrated previously to induce partial immune protection, fulfilled criteria of broad interstrain B and T cell epitope conservation, and thus was further characterized. The RAP-1 gene family consists of at least two gene copies, is homologous to the RAP-1 gene family in B. bigemina, and contains significant sequence similarity to other erythroparasitic protozoan candidate vaccine antigens, including the apical membrane antigen of Plasmodium falciparum. A new RAP-1 monoclonal antibody was developed that inhibits merozoite growth in vitro, demonstrating the presence of a RAP-1 neutralization sensitive domain. Based on these observations, cattle were immunized with Mo7 (Mexico) strain recombinant RAP-1 representing one of the two gene copies. All cattle responded with variable levels of serum antibodies inhibitory to heterologous Israel strain merozoite growth in vitro, and RAP-1 specific T lymphocytes that proliferated when stimulated with either homologous or heterologous native parasite antigen. Minimal protection from clinical disease was present after virulent Israel (heterologous) strain B. bovis challenge. In total, the results support the continued development of RAP-1 as a vaccine antigen, but indicate that additional information about the native structure and function of both RAP-1 gene copies, including the relationship of conserved and polymorphic sequences to B and T cell lepitopes relevant for protection, is necessary for optimization of RAP-1 as a vaccine component.

Gli stili APA, Harvard, Vancouver, ISO e altri

Offriamo sconti su tutti i piani premium per gli autori le cui opere sono incluse in raccolte letterarie tematiche. Contattaci per ottenere un codice promozionale unico!