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Letteratura scientifica selezionata sul tema "Platelets"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Platelets"

Beaulieu, Lea, Kahraman Tanriverdi, Jane Freedman, and Lauren Clancy. "The role of RNA uptake in platelet heterogeneity." Thrombosis and Haemostasis 117, no. 05 (2017): 948–61. http://dx.doi.org/10.1160/th16-11-0873.

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SummaryThe role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a role for platelet transcripts in vascular function. As the RNA in anucleated platelets is biologically functional and may transfer to other vascular cells, we hypothesised that platelet RNA diminishes over the lifespan of the platelet with diminishing platelet size due to horizontal cellular transfer. The purpose of this study is to determine if plate

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Franco, Aime T., Adam Corken, and Jerry Ware. "Platelets at the interface of thrombosis, inflammation, and cancer." Blood 126, no. 5 (2015): 582–88. http://dx.doi.org/10.1182/blood-2014-08-531582.

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Abstract Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have the ability to influence a wide range of seemingly unrelated pathophysiologic events. Here, we highlight some of the notable observations that link platelets to inflammation, reinforcing the platelet’s origin from a lower vertebrate cell type with both hemostatic and immunologic roles. In addition, we consider the relevance of platelets in cancer biology by focusing on the hallmarks of cancer and the way

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Krisch, Linda, Gabriele Brachtl, Sarah Hochmann, et al. "Improving Human Induced Pluripotent Stem Cell-Derived Megakaryocyte Differentiation and Platelet Production." International Journal of Molecular Sciences 22, no. 15 (2021): 8224. http://dx.doi.org/10.3390/ijms22158224.

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Several protocols exist for generating megakaryocytes (MKs) and platelets from human induced pluripotent stem cells (hiPSCs) with limited efficiency. We observed previously that mesoderm induction improved endothelial and stromal differentiation. We, therefore, hypothesized that a protocol modification prior to hemogenic endothelial cell (HEC) differentiation will improve MK progenitor (MKP) production and increase platelet output. We further asked if basic media composition affects MK maturation. In an iterative process, we first compared two HEC induction protocols. We found significantly mo

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Campbell, Robert A., Thomas H. Fischer, and Alisa S. Wolberg. "Rehydrated, Lyophilized Platelets Generate Thrombin in the Presence of Recombinant Factor VIIa." Blood 106, no. 11 (2005): 4057. http://dx.doi.org/10.1182/blood.v106.11.4057.4057.

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Abstract The anti-bleeding therapy, recombinant factor VIIa (rFVIIa), is thought to bind to the platelet’s surface and increase thrombin generation in hemophilia. However, high plasma levels of rFVIIa are required, in part, due to the weak binding of rFVIIa to platelets. We hypothesized that the efficacy of the therapy could be improved by administering rFVIIa already bound to platelets. A recently described protocol involving pretreatment of platelets with paraformaldehyde permits platelets to be lyophilized while preserving many platelet functions. Such platelets could be used for binding rF

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Yang, Linlin, Roger Ottenheijm, Paul Worley, Marc Freichel, and Juan E. Camacho Londoño. "Reduction in SOCE and Associated Aggregation in Platelets from Mice with Platelet-Specific Deletion of Orai1." Cells 11, no. 20 (2022): 3225. http://dx.doi.org/10.3390/cells11203225.

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Calcium signalling in platelets through store operated Ca2+ entry (SOCE) or receptor-operated Ca2+ entry (ROCE) mechanisms is crucial for platelet activation and function. Orai1 proteins have been implicated in platelet’s SOCE. In this study we evaluated the contribution of Orai1 proteins to these processes using washed platelets from adult mice from both genders with platelet-specific deletion of the Orai1 gene (Orai1flox/flox; Pf4-Cre termed as Orai1Plt-KO) since mice with ubiquitous Orai1 deficiency show early lethality. Platelet aggregation as well as Ca2+ entry and release were measured i

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Smith, Clark M., Steven M. Burris, Douglas J. Weiss, and James G. White. "Comparison of bovine and human platelet deformability, using micropipette elastimetry." American Journal of Veterinary Research 50, no. 1 (1989): 34–38. https://doi.org/10.2460/ajvr.1989.50.01.34.

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SUMMARY We evaluated the deformability of bovine platelets and contrasted the effects of pharmacologic and thermal perturbations on cytoskeletal structure of human and bovine platelets. Platelets were aspirated into micropipettes (0.7 to 0.8 μm in diameter) by stepwise increments in tension. The resulting lengths of the cell extensions were recorded. The cell extensions aspirated from bovine platelets were shorter than the extensions drawn from human platelelets. Disassembly of the circumferential microtubule coil allowed human platelets to pass through the pipette, but the same treatments onl

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Crawford, N., A. Chajara, G. Pfliegler, B. EI Gamal, L. Brewer, and L. Capron. "Targeting Platelets Containing Electro-encapsulated lloprost to Balloon Injured Aorta in Rats." Thrombosis and Haemostasis 73, no. 03 (1995): 535–42. http://dx.doi.org/10.1055/s-0038-1653809.

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SummaryDrugs can be electro-encapsulated within platelets and targeted to damaged blood vessels by exploiting the platelet’s natural haemostatic properties to adhere to collagen and other vessel wall constituents revealed by injury. A rat aorta balloon angioplasty model has been used to study the effect on platelet deposition of giving iloprost loaded platelets i.v. during the balloon injury. After labelling the circulating platelets with 111-Indium before balloon injury, time course studies showed maximum platelet deposition on the injured aorta occurred at about 1 h post-injury and the depos

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Battinelli, Elisabeth M. "Platelet and Megakaryocytic Regulation of Tumor Progression." Blood 130, Suppl_1 (2017): SCI—26—SCI—26. http://dx.doi.org/10.1182/blood.v130.suppl_1.sci-26.sci-26.

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Traditionally viewed as the bandaids of the blood, the contribution of platelets to the progression of malignancy is emerging as a compelling focus for therapeutic intervention. Complex interactions between tumor cells, and circulating platelets play an important role in tumor growth and dissemination, and a growing body of data supports a role for platelet activation and release of chemokines in metastases and neovascularization. Supporting this concept is the evidence that elevated platelet counts (thrombocytosis) at time of diagnosis with malignancy is a harbinger of an aggressive cancer wi

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Puricelli, Chiara, Elena Boggio, Casimiro Luca Gigliotti, et al. "Platelets, Protean Cells with All-Around Functions and Multifaceted Pharmacological Applications." International Journal of Molecular Sciences 24, no. 5 (2023): 4565. http://dx.doi.org/10.3390/ijms24054565.

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Platelets, traditionally known for their roles in hemostasis and coagulation, are the most prevalent blood component after erythrocytes (150,000–400,000 platelets/μL in healthy humans). However, only 10,000 platelets/μL are needed for vessel wall repair and wound healing. Increased knowledge of the platelet’s role in hemostasis has led to many advances in understanding that they are crucial mediators in many other physiological processes, such as innate and adaptive immunity. Due to their multiple functions, platelet dysfunction is involved not only in thrombosis, mediating myocardial infarcti

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Cheepala, Satish B., Kazumasa Takenaka, Tamara I. Pestina, Carl W. Jackson, and John D. Schuetz. "The Role of ABC Transporter Abcc4 in Platelets Physiologic Function and Its Impact On Collagen Meditated Platelet Aggregation." Blood 120, no. 21 (2012): 1063. http://dx.doi.org/10.1182/blood.v120.21.1063.1063.

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Abstract Abstract 1063 Platelet activation is a highly regulated process, and cyclic nucleotide mediated signaling pathways are crucial to effective platelet activation. Vascular injury produces, exposed collagen which binds circulating platelets through the platelet's “collagen” receptor, GPVI, resulting in the activation of guanyly/adenlyl cyclases. These interactions result in the rapid alterations in the cyclic nucleotide concentration inside the platelets leading to activation of protein kinase A and G signaling pathways to modulate platelet function. While, ABCC4 functions as a plasma me

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Tesi sul tema "Platelets"

MacMillan, L. J. M. "Receptor mechanisms common to platelets and platelet progenitor cells." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233116.

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Box, Clare Louise. "Interactions between platelets and platelet derived microvesicles in inflamation." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5818/.

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Atherosclerosis is a chronic inflammatory disease, characterised by infiltration of leukocytes and accumulation of fatty deposits in the artery wall. Early events in this disease process include recruitment of platelets to the artery wall, which in turn aid in leukocyte recruitment. However, upon activation platelets release microvesicles (PMV), we are interested in whether PMV have a role in enhancing leukocyte recruitment. We demonstrated using whole blood that upon activation, platelets form aggregates with monocytes and neutrophils. The data suggests that upon platelet activation, PMV may

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Taha, Mariam. "Bacterial Contamination of Platelet Concentrates: Role of Biofilm Formation and Manufacturing Process." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35192.

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Bacterial contamination of platelet concentrates (PCs) poses the highest transfusion-associated infectious risk with skin flora, such as Staphylococcus epidermidis and Staphylococcus capitis, being the predominant contaminants. These bacteria are able to form surface-attached aggregates or biofilms, which are present in the skin of healthy blood donors and can subsequently be isolated from contaminated PCs. Disinfection of the venipuncture area before donation with a combination of 2% chlorhexidine-gluconate and 70% isopropanol is used at Canadian Blood Services. However, not all bacteria a

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Hayman, Melissa Anne. "Genomic influences on platelet function." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/36221.

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The study of platelet messenger and micro-RNAs is of increasing interest owing to the fact that platelets contain the machinery to splice and translate mRNA into proteins in response to inhibitory or activating signals. However, the relatively small size (roughly 4000-5000 transcripts) and short half-life of the platelet transcriptome makes this a technically challenging aspect of platelet biology to investigate. The aims of these thesis investigations were therefore to optimise protocols for the isolation of platelets for downstream RNA analyses and function testing, to investigate the functi

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Hamali, Hassan A. A. "Regulation of the procoagulant activity of platelets and platelet-derived microparticles." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10046.

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Procoagulant microparticles (MPs) in the circulation are increasingly recognized as playing a role in haemostasis and inflammation and may prove useful biomarkers for clinical studies. Platelets are known to generate MPs in response to stimulation, and platelet-derived MPs (PDMPs) form the majority of the MPs found in the normal circulation and can be elevated in a number of disease states. The current study has focused on the procoagulant activity of platelets and PDMPs following stimulation with the collagen-mimetic peptide CRP-XL. Their activity in accelerating thrombin generation can be ac

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Murphy, Christine Therese. "Mechanisms of stimulus-response coupling in platelet-activating factor stimulated platelets." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304999.

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Arunima, Ghosh. "Role of CD36 in Platelet Function." Cleveland State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=csu1199991110.

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Hamad, Osama A. "Crosstalk Between Activated Platelets and the Complement System." Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123681.

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Several studies have shown that complement and thrombotic events co-exist. Platelets have been suspected to act as the bridge between the two cascade systems. To study the platelet-induced complement activation we developed a system in which platelets were activated by thrombin receptor activating peptide (TRAP) in platelet rich plasma (PRP) or whole blood anti-coagulated using the specific thrombin inhibitor, lepirudin. TRAP-activated platelets induced a fluid-phase complement activation measured as generation of C3a and sC5b-9, triggered by released chondroitin sulphate-A (CS-A) which intera

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Battram, Anthony Matthew. "The role and regulation of Rasa3 in platelets and platelet cell models." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.702741.

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Upon vascular insult, platelets are recruited to the site of injury, are activated, and form a haemostatic plug to prevent bleeding. However, inappropriate platelet activation can lead to the formation of occluding thrombi in arteries and veins in a process known as thrombosis. The GTPase Rap1 plays a critical role in platelet activation by regulating the affinity state of the fibrinogen receptor, integrin allbb3. The aim of this thesis was to ascertain the role and regulation of a Rap1-targeting GTPase-activating protein (GAP), Rasa3 (previously GAP1lP4BP), in platelet signal transduction and

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Eriksson, Andreas. "Platelet Adhesion to Proteins in Microplates : Applications in Experimental and Clinical Research." Doctoral thesis, Linköping : Department of Medical and Health Sciences, Linköping University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11733.

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Più fonti

Libri sul tema "Platelets"

D, Michelson Alan, ed. Platelets. 2nd ed. Academic Press/Elsevier, 2007.

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D, Michelson Alan, ed. Platelets. Academic Press, 2002.

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M, Smith Dennis, and Summers Stephanie, eds. Platelets. American Association of Blood Banks, 1988.

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J, Westwick, ed. Mechanisms of stimulus-response coupling in platelets. Plenum Press, 1985.

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Gibbins, Jonathan M., and Martyn P. Mahaut-Smith. Platelets and Megakaryocytes. Humana Press, 2004. http://dx.doi.org/10.1385/1592597823.

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Gibbins, Jonathan M., and Martyn P. Mahaut-Smith. Platelets and Megakaryocytes. Humana Press, 2004. http://dx.doi.org/10.1385/1592597831.

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Kessler, Christof, ed. Platelets and Atherosclerosis. Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-58225-7.

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Gibbins, Jonathan M., and Martyn P. Mahaut-Smith, eds. Platelets and Megakaryocytes. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-61779-307-3.

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Gibbins, Jonathan M., and Martyn Mahaut-Smith, eds. Platelets and Megakaryocytes. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8585-2.

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1942-, Phillips David R., and Shuman Marc A, eds. Biochemistry of platelets. Academic Press, 1986.

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Capitoli di libri sul tema "Platelets"

Michelson, Alan D., and Sanford J. Shattil. "The use of flow cytometry to study platelet activation." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0006.

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Abstract Many common clinical conditions have been reported to be associated with platelet hyperreactivity and/or circulating activated platelets: coronary artery disease (angina pectoris, acute myocardial infarction) diabetes mellitus stroke exercise emotional stress cigarette smoking pregnancy and pre-eclampsia blood bank storage of platelets for transfusion cardiopulmonary bypass angioplasty deep vein thrombosis hyperlipoproteinaemia essential thrombocythemia adult respiratory distress syndrome However, the role of platelet activation in clinical settings is controversial, in part because t

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A. Matthay, Zachary, and Lucy Zumwinkle Kornblith. "Platelet Imaging." In Platelets. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.91736.

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The knowledge gained through imaging platelets has formed the backbone of our understanding of their biology in health and disease. Early investigators relied on conventional light microscopy with limited resolution and were primarily able to identify the presence and basic morphology of platelets. The advent of high resolution technologies, in particular, electron microscopy, accelerated our understanding of the dynamics of platelet ultrastructure dramatically. Further refinements and improvements in our ability to localize and reliably identify platelet structures have included the use of im

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Clemetson, Kenneth J. "Clinical aspects of platelet function." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0015.

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Abstract 1. Introduction Since the primary function of platelets is haemostasis, or stopping bleeding, platelet dysfunction is generally seen as an under–or over-expression of this, i.e. in bleeding problems or in various haemostatic or thrombotic disorders. The first task of the clinician faced with such symptoms is to eliminate the possibility of the disorder being produced by a lack or defect in plasma coagulation factors such as factor VIII, von Willebrand factor, fibrinogen, factor IX, factor V, etc. which are commonly affected. Having shown that these lie within the normal range it is ne

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K. Poddar, Mrinal, and Soumyabrata Banerjee. "Molecular Aspects of Pathophysiology of Platelet Receptors." In Platelets. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.92856.

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Receptor is a dynamic instrumental surface protein that helps to interact with specific molecules to respond accordingly. Platelet is the smallest in size among the blood components, but it plays many pivotal roles to maintain hemostasis involving its surface receptors. It (platelet) has cell adhesion receptors (e.g., integrins and glycoproteins), leucine-rich repeats receptors (e.g., TLRs, glycoprotein complex, and MMPs), selectins (e.g., CLEC, P-selectin, and CD), tetraspanins (e.g., CD and LAMP), transmembrane receptors (e.g., purinergic—P2Y and P2X1), prostaglandin receptors (e.g., TxA2, P

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Águila, Sonia, Ernesto Cuenca-Zamora, Constantino Martínez, and Raúl Teruel-Montoya. "MicroRNAs in Platelets: Should I Stay or Should I Go?" In Platelets. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93181.

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In this chapter, we discuss different topics always using the microRNA as the guiding thread of the review. MicroRNAs, member of small noncoding RNAs family, are an important element involved in gene expression. We cover different issues such as their importance in the differentiation and maturation of megakaryocytes (megakaryopoiesis), as well as the role in platelets formation (thrombopoiesis) focusing on the described relationship between miRNA and critical myeloid lineage transcription factors such as RUNX1, chemokines receptors as CRCX4, or central hormones in platelet homeostasis like TP

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Butt, Elke, and Ulrich Walter. "Cyclic nucleotides: measurement and function." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0013.

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Abstract The activation of human platelets is inhibited by a variety of agents which exert their effects through distinct mechanisms. Examples include inhibitors of thromboxane A2 generation (e.g. aspirin), inhibitors of thrombin (e.g. hirudin), scavengers of ADP (e.g. apyrase), and physiological and pharmacological cyclic nucleotide-elevating agents (1,2). Vascular endothelial cells, under basal conditions and in response to numerous vasoactive agents, synthesize and release prostacyclin (PGI2) and endothelium-derived relaxing factor, nitric oxide (EDRF; or NO), two of the most important phys

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Mcgregor, John L., Odile Gayet, Nathalie Mercier, Lilian Mcgregor, and Elza Chignier. "Identification, isolation, and characterization of platelet glycoproteins mediating platelet adhesion." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0007.

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Abstract Platelets play a vital role in haemostasis by the formation of a plug or thrombus at a site of vessel wall injury. The function of these anucleated cells is largely dependent on the presence of a number of glycoproteins. Moreover, adhesion and aggregation of platelets to disrupted atheroma plaque, leading in some cases to vessel occlusion, is also mediated by glycoproteins. The importance of glycoproteins in platelet functions has led to extensive work, using various techniques, to identify structural/functional sites on these glycoproteins implicated in interacting with various ligan

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Israels, Sara J., and Jon M. Gerrard. "lmmunocytochemical and electron microscopic studies of platelets." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0014.

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Abstract Although platelets were one of the first types of cells to be studied using the electron microscope, a clear understanding of normal platelet architecture using electron microscopy had to await improved techniques for the isolation, preservation, and fixation of these cells. Similarly, an understanding of the changes in blood platelet fine structure during clotting required improvements in preparative techniques. The preservation and fixation of certain platelet subcellular structures, notably dense granules and contractile filaments, have presented particular challenges. In this chap

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Wilkinson, J. Michael. "Monoclonal antibodies to platelet cell surface antigens and their use." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0008.

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Abstract The introduction of the technique of monoclonal antibody (mAb) preparation in 1975 revolutionized the study of cell surface molecules, and this has been as true for platelets as for any other type of cell. mAb have been used both to characterize molecules previously defined by other methods and also to identify new molecules, by immunization of mice with whole platelets or platelet plasma membrane fractions. Like any other cell type, platelets express a wide variety of cell surface proteins whose surface density may vary from tens to tens of thousands of molecules per cell. Many of th

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Bevers, Edouard M., Paul Comfurius, Chrisp M. Reutelingsperger, and Robert F. A. Zwaal. "Platelet procoagulant activity and its measurement." In Platelets. Oxford University PressOxford, 1996. http://dx.doi.org/10.1093/oso/9780199635382.003.0016.

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Abstract Platelets serve an important function in the haemostatic process. Vessel wall injury causes exposure of subendothelial structures to the blood stream and initiates the process of platelet adhesion, aggregation, and release of granule contents resulting in formation of the primary haemostatic plug. Tissue thromboplastin, released by the damaged vessel wall, initiates activation of the coagulation pathway, leading to formation of thrombin. The action of thrombin on soluble plasma fibrinogen gives rise to deposition of an insoluble fibrin network which consolidates the primary haemostati

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Atti di convegni sul tema "Platelets"

Jansen, J. W. C. M. "EFFECTS OF INHIBITORS ON COLLAGEN INDUCED PLATELET AGGREGATION IN SIX DIFFERENT SPECIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643445.

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One approach to the development of antithrombotics is inhibition of platelet aggregation. The pharmacological approach often used is to test compounds on collagen induced platelet aggregation measured in platelet rich plasma. Therefore we have compared inhibitors with different mechanism of action on aggregation of platelets from six different species commonly used in pharmacological studies. Aggregation was induced with submaximal amounts of collagen (Hormone Chemie).Inhibitors of the cyclooxygenase system, aspirin and indomethacin, were very potent in inhibiting aggregation of platelets from

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Ordinas, A., E. Bastida, M. Garrido, J. Monteagudo, L. de Marco, and R. Castillo. "ASIALO VON WILLEBRAND FACTOR ENHANCES PLATELET ADHESION TO VASCULAR SUBENDOTHELIUM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644098.

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Native Von Willebrand factor (NvWF) binds to platelets activated by thrombin, ADP or ristocetin, and also supports the adhesion of platelets to subendothelium at high shear rates. In contrast, asialo von Willebrand factor (AvWF) induces platelet aggregation in absence of platelet activators. We investigated the role of AvWF in supporting the adhesion of platelets to rabbit vessel subendothelium under flow conditions at a shear rate of 2000 sec-1 for 5 min using the Baumgartner perfusion system. We also studied the effects of blockage of platelet GPIb or GPIIb/IIIa on platelet adhesion using mo

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Struk, A., A. Prins, M. C. L. Schaap, J. W. ten Cate, and H. van den Bosch. "SYNTHESIS OF PLATELET ACTIVATING FACTOR BY HUMAN BLOOD PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643486.

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Synthesis of platelet activating factor (PAF) by human blood platelets is a controversial issue. Whereas some groups have reported the synthesis, induced by thrombin, collagen or Ca2--ionophore Azsio?, others were unable to obtain for instance the thrombin-induced PAF synthesis. Also, synthesis of only up to 6 pMoles PAF/10 platelets has been reported, but leucocytes may synthesize up to 6000 pMoles PAF/10 cells. Only an 0.1% leucocyte contamination would thereby explain the “ platelet PAF synthesis” . We therefore optimized the PAF synthesis by human blood platelets and leucocytes, induced by

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Yamazaki, H., K. Tanoue, K. Kuroiwa, H. Suzuki, M. Shibayama, and Y. Mano. "ACQUIRED STORAGE POOL DISEASE IN DECOMPRESSION SICKNESS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644563.

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The presence of hemostatic abnormalities has been reported in decompression sickness. It is suggested that platelets recognize air bubbles in the blood stream as a foreign surface and adhere to them with ensuing platelet aggregation. It is important to determine if consumption of platelets occurs in vivo to understand a role of platelets in the genesis of decompression sickness. To analyse the problem, platelet behavior was studied in 34 rabbits with decompression sickness which was brought about by the exposure to 6 ATA (atmospheres absolute) for 40 min followed by rapid decompression. All ra

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Vanhoutte, Paul M. "PLATELETS, ENDOTHELIUM AND VASOSPASM." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643722.

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The endothelium can secrete both relaxing and contracting substances. One of the most powerful stimuli to the release of the former are thrombin and aggregating platelets. This contributes to the protective role of the endothelium against inappropriate intraluminal platelet aggregation and coagulation in blood vessels with an intact intima. Thrombin-induced, endothelium-dependent relaxations have been obtained in isolated arteries of different species, including humans. Endothelium-dependent relaxations can be evoked by autologous platelets in isolated blood vessels of the dog, pig and rat; th

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Suzuki, Sozo, Kazuo Mori, Koji Sugai, et al. "ELECTRONMICROSCOPIC STUDIES ON PLATELETS AND MEGAKARYOCYTES IN GIANT PLATELET SYNDROME." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644560.

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Giant platelet syndrome are characterized morphologically by many giant platelets associated with several functional abnormalities in the peripheral blood. However, the mechanism of large platelet production has not yet been clarified. In 1981, we reported acase with Bernard-Soulier syndrome(BSS) in whom giant platelets were considered to be formed by fusion of two or three platelets in the circulating blood. We examined the ultrastructure of platelets and megakaryocytes in another case with BSS (29 year-old female) and a case with May-Hegglin anomaly (31 year-old male). Whole blood and bone m

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Bauman, J. E., J. H. Joist, G. Vogler, and S. P. Sutera. "HIGH SUSCEPTIBILITY OF RABBIT, DOG, AND PIG PLATELETS TO SHEAR-INDUCED INJURY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642846.

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In an attempt to develop an animal model for the study of the effects of fluid shear stress on platelet in vivo survival we examined the effects of repetitive short-duration (5 sec) and continuous prolonged (5 min) shear exposure in a cone-plate viscometer and Couette rotational viscometer on platelets (in citrated platelet-rich plasma) from humans, rabbits, dogs, and pigs. Comparable platelet aggregation (PAG = loss of single platelets) (18-64%) was observed with platelets from all species, associated with dense granule release, as a function of shear stress amplitude (25-50 dyn/cm2) under th

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Lian, E. C. Y., and F. A. Siddigui. "BINDING OF 37-DKa PLATELET AGGLUTINATING PROTEIN TO HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643976.

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We have previously reported the purification of a 37-KDa platelet agglutinating protein (PAP p37) from the plasma of a patient with thrombotic thrombocytopenic purpura. using 125I-labeled p37, the properties of its binding to platelets were studied. The binding of p37 to washed human platelets from 4 normal subjects and two TTP patients after recovery was specific, concentration dependent and saturable. The Scatchard analysis revealed that the binding sites for p37 was about 100,000 per platelet with a dissociation constant of 48 × 10−9 M. The binding of p37 to erythrocytes was very little and

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Cattaneo, M., M. T. Canciani, and J. F. Mustard. "ROLE OF RELEASED ADP IN THE STABILIZATION OF PLATELET AGGREGATES: STUDIES IN PATIENTS WITH DEFICIENCY IN AMINE STORAGE GRANULES CONTENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644745.

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Human platelets aggregated by thrombin (T) under conditions in which the release reaction (RR) occurs to only a small extent can be deaggregated by agents that dissociate 125I-fibrinogen bound to platelets. In contrast, when platelets undergo the RR, they cannot be reading deaggregated even though combinations of inhibitors cause 125I-fibrinogen to dissociate. Therefore, material released from platelet granules seems to stabilize aggregates. T-induced aggregates of washed platelets deficient in fibrinogen or von Willebrand factor cannot be deaggregated readily by deaggregating agents, implying

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Evans, R. M., and M. A. Packham. "THE EFFECT OF ENZYMATIC TREATMENT OF RABBIT PLATELETS ON THE BINDING OF IMMUNOGLOBULIN G TO THE SURFACE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643504.

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As shown previously, cleavage of surface glycoproteins on the platelet membrane shortens platelet survival. Since immunoglobulins have been implicated in the condition of idiopathic thrombocytopenic purpura in which patients have an elevated level of platelet-associated immunoglobulin G (I g G) and shortened platelet survival, we measured the binding of IgG to rabbit platelets that had been treated with neuraminidase or plasmin, to determine whether increased IgG binding to these platelets might be the signal that leads to their accelerated clearance. Rabbit platelets were washed and resuspend

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Rapporti di organizzazioni sul tema "Platelets"

Soogarun, Suphan. Study the effect of green pit viper (Trimeresurus albolabris) venom on platelet morphology. Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.82.

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The incidence of venomous snake bites increases in every year in Thailand, especially by green pit viper. Consequence after the bite is bleeding because of its thrombin-like property. There is a report mentioned that the mean platelet volume was decreased in those who had been bitten by this snake. In this study is to investigate the effect of green pit viper (Trimeresurus albolabris) on platelet volume (MPV), number of platelets and morphology in vitro. The test carried out by washing platelet in phosphate buffer pH 7.2 so as to get rid fibrinogen, and then washed platelets were mixed with gr

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Slichter, Sherrill J. Pathogen-Reduced, Plasmalyte-Extended Stored Platelets (PREPS). Defense Technical Information Center, 2013. http://dx.doi.org/10.21236/ada612437.

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Michelson, A. D., M. R. Barnard, H. B. Hechtman, H. Macgregor, and R. J. Connolly. In Vivo Tracking of Platelets: Circulating Degranulated Platelets Rapidly Lose Surface P-Selectin but Continue to Circulate and Function. Defense Technical Information Center, 1995. http://dx.doi.org/10.21236/ada360258.

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Bode, Arthur P., and Thomas H. Fisher. Immunogenicity and Stability of Lyophilized Platelets for Transfusion Medicine. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada406020.

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Petrova, I. V., O. A. Trubacheva, O. S. Mangataeva, T. E. Suslova, I. V. Kovalev, and S. V. Gusakova. INFLUENCE OF HYDROGEN SULFIDE ON COLLAGEN-INDUCED AGGREGATION OF HUMAN PLATELETS. DOI CODE, 2015. http://dx.doi.org/10.18411/doicode-2023.141.

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Zuckerman, Kenneth S. Reparative Medicine: Production of Erythrocytes & Platelets from Human Embryonic Stem Cells. Defense Technical Information Center, 2012. http://dx.doi.org/10.21236/ada566171.

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Bode, Arthur P. Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality. Defense Technical Information Center, 1994. http://dx.doi.org/10.21236/ada280665.

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Bode, Arthur P., and Marjorie S. Read. Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada254796.

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Bode, Arthur P. Evaluation of Dried Storage of Platelets for Transfusion: Physiologic Integrity and Hemostatic Functionality. Defense Technical Information Center, 1993. http://dx.doi.org/10.21236/ada266958.

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