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Letteratura scientifica selezionata sul tema "PLUMBAGIN PRODUCTION"

Autore: Grafiati

Pubblicato: 11 settembre 2023

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Articoli di riviste sul tema "PLUMBAGIN PRODUCTION"

Paiva, Selma R., Lucilene A. Lima, Maria Raquel Figueiredo e Maria Auxiliadora C. Kaplan. "Chemical composition fluctuations in roots of Plumbago scandens L. in relation to floral development". Anais da Academia Brasileira de Ciências 83, n. 4 (dicembre 2011): 1165–70. http://dx.doi.org/10.1590/s0001-37652011000400004.

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Plumbago scandens L. is a Brazilian tropical/subtropical species that occurs along the coast. Chemically it is mainly represented by naphthoquinones, flavonoids, terpenoids and steroids. The aim of the present work is to study quantitative changes in the root metabolic production of Plumbago scandens during different physiologic developmental stages relative to floration. The results indicated the presence of four substances in the extracts: plumbagin, epi-isoshinanolone, palmitic acid and sitosterol, independent on developmental stage. The naphthoquinone plumbagin has always showed to be the major component of all extracts. Naphthoquinones exhibited their highest content during floration, while the content of the two others components decreased during this stage, revealing an inverse profile. The chemical composition changed depending on the plant requirements.

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Sakamoto, Seiichi, Waraporn Putalun, Benyakan Pongkitwitoon, Thaweesak Juengwatanatrakul, Yukihiro Shoyama, Hiroyuki Tanaka e Satoshi Morimoto. "Modulation of plumbagin production in Plumbago zeylanica using a single-chain variable fragment antibody against plumbagin". Plant Cell Reports 31, n. 1 (11 settembre 2011): 103–10. http://dx.doi.org/10.1007/s00299-011-1143-6.

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Gangopadhyay, Moumita, Saikat Dewanjee e Sabita Bhattacharya. "Enhanced plumbagin production in elicited Plumbago indica hairy root cultures". Journal of Bioscience and Bioengineering 111, n. 6 (giugno 2011): 706–10. http://dx.doi.org/10.1016/j.jbiosc.2011.02.003.

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Gangopadhyay, Moumita, Saikat Dewanjee, Somnath Bhattacharyya e Sabita Bhattacharya. "Effect of Different Strains of Agrobacterium rhizogenes and Nature of Explants on Plumbago indica Hairy Root Culture with Special Emphasis on Root Biomass and Plumbagin Production". Natural Product Communications 5, n. 12 (dicembre 2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501215.

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The aim of the present study was to determine the effect of three strains of Agrobacterium rhizogenes (ATCC 15834, A4 and LBA 9402) and the nature of explants (leaf and stem) on hairy root induction, growth and plumbagin production in Plumbago indica. The first appearance of hairy roots, the transformation frequency, dry root biomass and plumbagin accumulation were found to be maximum in hairy roots induced in leaf explants infected with A. rhizogenes ATCC 15834 as compared with the other two bacterial strains. The hairy roots generated from stem explants infected with all three strains were not found to be productive in terms of the selected parameters. Finally, the insertion of the rolB gene of A. rhizogenes ATCC 15834 in hairy roots of P. indica derived from leaf explants was confirmed by PCR analysis.

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Beigmohammadi, Mina, Ali Movafeghi, Ali Sharafi, Samineh Jafari e Hossein Danafar. "Cell Suspension Culture of Plumbago europaea L. Towards Production of Plumbagin". Iranian Journal of Biotechnology 17, n. 2 (1 giugno 2019): 46–54. http://dx.doi.org/10.21859/ijb.2169.

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Beigmohamadi, Mina, Ali Movafeghi, Samineh Jafari e Ali Sharafi. "Efficient in vitro organogenesis, micropropagation, and plumbagin production in Plumbago europaea L." In Vitro Cellular & Developmental Biology - Plant 57, n. 5 (28 settembre 2021): 820–30. http://dx.doi.org/10.1007/s11627-021-10224-x.

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Komaraiah, P., R. Naga Amrutha, P. B. Kavi Kishor e S. V. Ramakrishna. "Elicitor enhanced production of plumbagin in suspension cultures of Plumbago rosea L." Enzyme and Microbial Technology 31, n. 5 (ottobre 2002): 634–39. http://dx.doi.org/10.1016/s0141-0229(02)00159-x.

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Roy, Arpita, e Navneeta Bharadvaja. "Establishment of root suspension culture of Plumbago zeylanica and enhanced production of plumbagin". Industrial Crops and Products 137 (ottobre 2019): 419–27. http://dx.doi.org/10.1016/j.indcrop.2019.05.007.

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Chrastina, Adrian, John Welsh, Per Borgström e Veronique T. Baron. "Propylene Glycol Caprylate-Based Nanoemulsion Formulation of Plumbagin: Development and Characterization of Anticancer Activity". BioMed Research International 2022 (10 gennaio 2022): 1–9. http://dx.doi.org/10.1155/2022/3549061.

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Abstract (sommario):

Plumbagin, a bioactive naphthoquinone, has demonstrated potent antitumor potential. However, plumbagin is a sparingly water-soluble compound; therefore, clinical translation requires and will be facilitated by the development of a new pharmaceutical formulation. We have generated an oil-in-water nanoemulsion formulation of plumbagin using a low-energy spontaneous emulsification process with propylene glycol caprylate (Capryol 90) as an oil phase and Labrasol/Kolliphor RH40 as surfactant and cosurfactant excipients. Formulation studies using Capryol 90/Labrasol/Kolliphor RH40 components, based on pseudoternary diagram and analysis of particle size distribution and polydispersity determined by dynamic light scattering (DLS), identified an optimized composition of excipients for nanoparticle formulation. The nanoemulsion loaded with plumbagin as an active pharmaceutical ingredient had an average hydrodynamic diameter of 30.9 nm with narrow polydispersity. The nanoemulsion exhibited long-term stability, as well as good retention of particle size in simulated physiological environments. Furthermore, plumbagin-loaded nanoemulsion showed an augmented cytotoxicity against prostate cancer cells PTEN-P2 in comparison to free drug. In conclusion, we generated a formulation of plumbagin with high loading drug capacity, robust stability, and scalable production. Novel Capryol 90-based nanoemulsion formulation of plumbagin demonstrated antiproliferative activity against prostate cancer cells, warranting thus further pharmaceutical development.

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Li, Guiyu, Yue Peng, Tiejian Zhao, Jiyong Lin, Xuelin Duan, Yanfei Wei e Jing Ma. "Plumbagin Alleviates Capillarization of Hepatic Sinusoids In Vitro by Downregulating ET-1, VEGF, LN, and Type IV Collagen". BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/5603216.

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Critical roles for liver sinusoidal endothelial cells (LSECs) in liver fibrosis have been demonstrated, while little is known regarding the underlying molecular mechanisms of drugs delivered to the LSECs. Our previous study revealed that plumbagin plays an antifibrotic role in liver fibrosis. In this study, we investigated whether plumbagin alleviates capillarization of hepatic sinusoids by downregulating endothelin-1 (ET-1), vascular endothelial growth factor (VEGF), laminin (LN), and type IV collagen on leptin-stimulated LSECs. We found that normal LSECs had mostly open fenestrae and no organized basement membrane. Leptin-stimulated LSECs showed the formation of a continuous basement membrane with few open fenestrae, which were the features of capillarization. Expression of ET-1, VEGF, LN, and type IV collagen was enhanced in leptin-stimulated LSECs. Plumbagin was used to treat leptin-stimulated LSECs. The sizes and numbers of open fenestrae were markedly decreased, and no basement membrane production was found after plumbagin administration. Plumbagin decreased the levels of ET-1, VEGF, LN, and type IV collagen in leptin-stimulated LSECs. Plumbagin promoted downregulation of ET-1, VEGF, LN, and type IV collagen mRNA. Altogether, our data reveal that plumbagin reverses capillarization of hepatic sinusoids by downregulation of ET-1, VEGF, LN, and type IV collagen.

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Più fonti

Tesi sul tema "PLUMBAGIN PRODUCTION"

ROY, ARPITA. "BIOTECHNOLOGICAL APPROACHES FOR THE PRODUCTION OF PLUMBAGIN FROM PLUMBAGO ZEYLANICA". Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18075.

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Demand for medicinal plants has drastically enhanced due to the presence of therapeutically important compounds and is continuously rising in national and international markets. Exploring elite accession among numerous accessions, collected from different locations is an alternative approach to satisfy the increase demand of medicinal plants. Biotechnological approaches are reliable source for production of therapeutically important compound. It also provides long-term utilization of plants. Plumbago zeylanica, a pharmaceutically important medicinal plant has been explored in the present study. In vitro shoot culture was established for five accessions of Plumbago zeylanica. Four different plant tissue culture media, three different carbon sources and three different nitrogen sources were tested for five accessions of P. zeylanica to evaluate optimum culture condition based on growth. The accession which showed maximum shoots number was chosen for further investigation. Accession-based study of in vitro shoot culture showed that accession number IC 524441 is one of the elite accessions and chosen for further studies. Adventitious root suspension culture was explored for enhanced production of plumbagin. Optimization of adventitious root suspension culture showed that highest plumbagin production was obtained in ½ strength MS liquid media having 3% sucrose with 2 g/L of inoculum density. Further elicitation with yeast extract (150 mg/L) increases threefold plumbagin production as compared to control one and highest plumbagin production was 90.96±0.51 µg/mL. Further cell suspension culture was also explored for enhanced production of plumbagin. Optimization of cell suspension culture showed that MS medium having 1 mg/L NAA with 3 g/L inoculum density and 150mg/l yeast extract at pH 5.8 was optimal for plumbagin production. Maximum plumbagin production was enhanced up to 3.3 times as compared to control one and maximum amount of plumbagin production was 83.30±0.18 µg/mL. Biochemical analysis of thirteen different accessions of Plumbago zeylanica were performed where concentration of therapeutically important compounds such as total plumbagin, total flavonoids content, total phenol content, total tannin content and antioxidant activity were evaluated and results showed that IC-524441 is an elite accession. Same thirteen accessions were assessed for genetic diversity analysis using CBDP and SCoT marker. Genetically diverse accessions can be utilized by plant breeders for the generation of elite accessions which have high quantity of pharmaceutically important secondary metabolites. Further residual plant material of P. zeylanica was used for silver nanoparticles synthesis and its application in antibacterial and dye degradation were investigated. Biochar was also derived from residual shoot and root culture and its application in removal of cadmium and chromium were studied. Role of plumbagin against different cancer receptor using in silico method was also evaluated. The ligand plumbagin was docked against three different cancer receptors i.e. COX-2, EGFR and TACE to evaluate its potential effect on different cancer. In-silico studies showed that plumbagin is a potential therapeutic agent for treatment of cancer and same can be established through in vivo studies and clinical trials to confirm its efficiency in patients.

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RASTOGI, ANSHIKA. "BIOTIC ELICITORS USED TO ENHANCE PLUMBAGIN PRODUCTION IN PLUMBAGO ZEYLANICA AND ASSESMENT OF ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY". Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18363.

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Abstract (sommario):

Plumbago zeylanica (chitraka) is the most prominent herbal plant which is used as a medication to cure skin problems and infections such as ringworm, dermatitis, sores, acne and scabies. Traditionally all parts of Plumbago zeylanica have been utilized as a medication against many diseases. In Ayurveda chitraka is described as tumour- negating, appetizer, anti-anorexic and pain-reliever due to the presence of several important bioactive compounds such as alkaloid, tannins, phenols and naphthoquinones like plumbagin which is the most active constituent of this herb. Due to extensive use of this plant as a potent medicinal herb, micropropagation is necessary for higher biomass and plumbagin production. Since resistance to antibiotic against several microbes has become a critical issue in the whole world. So, to conquer this difficulty, identification and discovery new herbal drugs are necessary. In the current study, three elicitors namely yeast extract, malt extract and chitosan were used to enhance the plumbagin synthesis in Plumbago zeylanica as well as analysis of its antioxidant and antibacterial activity. Shoot culture of Plumbago zeylanica was performed in MS media which was supplemented with 200µl BAP and 150mg/l elicitors and then incubated for several weeks. Application of three biotic elicitors enhance the plumbagin production significantly. Phytochemical analysis of compound was carried out by UV-visible analysis which exhibited the presence of total phenol and tannin. DPPH free radical scavenging activity of all accession was performed to check their antioxidant potential. Cultures were also analysed for their antibacterial potential against E,coli and S.aureus. Results were expected that application of elicitors in Plumbago zeylanica shoot culture enhance the plumbagin production as well as other bioactive compounds.

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Capitoli di libri sul tema "PLUMBAGIN PRODUCTION"

Finnie, J. F., e J. van Staden. "Drosera spp. (Sundew): Micropropagation and the In Vitro Production of Plumbagin". In Biotechnology in Agriculture and Forestry, 164–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-58062-8_12.

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Šamaj, J., A. Blehová, M. Repčák, M. Ovečka e M. Bobák. "Drosera Species (Sundew): In Vitro Culture and the Production of Plumbagin and Other Secondary Metabolites". In Medicinal and Aromatic Plants XI, 105–35. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-662-08614-8_7.

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