Bibliografie tematiche / Polymorphisme social

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Letteratura scientifica selezionata sul tema "Polymorphisme social"

Autore: Grafiati
Pubblicato: 12 ottobre 2024
Ultima modifica: 19 luglio 2025

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Articoli di riviste sul tema "Polymorphisme social"

1

Johal, Gurinder, and Adam Amlani. "Integrating Pharmacogenomics into Clinical Practice." University of Ottawa Journal of Medicine 6, no. 1 (2016): 21–23. http://dx.doi.org/10.18192/uojm.v6i1.1549.

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Pharmacogenomics has the potential to improve patient-centered care and lead to an overall decrease in healthcare costs. This would be achieved through fewer hospitalizations due to adverse drug reactions, individualized and effective therapies, and decreased drug development costs with single nucleotide polymorphism pre-screening. Although challenges do exist in encouraging the use of phar­macogenomics―specifically in regards to resources, regulation, and impacts on the pharmaceutical industry―the benefits may out­weigh the costs in terms of patient health and safety. In implementing pharmaco
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2

Courtet, P. "Adversité sociale et troubles mentaux." European Psychiatry 29, S3 (2014): 629–30. http://dx.doi.org/10.1016/j.eurpsy.2014.09.131.

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Il est établi que les facteurs de risque sociaux jouent un rôle important dans la genèse et le maintien des troubles mentaux. Les modèles animaux nous indiquent que les expériences précoces d’adversité sociale peuvent avoir des effets à long terme à travers un « conditionnement biologique » et que le cerveau serait « modelé » par les facteurs environnementaux. En effet, des expériences sociales négatives très précoces peuvent avoir de profonds impacts durant les périodes de haute plasticité cérébrale lors de la vie prénatale et juste après la naissance. La recherche doit arriver à intégrer plu
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3

Balcerzyk-Matić, Anna, Tomasz Iwanicki, Alicja Jarosz, et al. "Analysis of the DYNC1H1 Gene Polymorphic Variants’ Association with ASD Occurrence and Clinical Phenotype of Affected Children." Genes 16, no. 5 (2025): 510. https://doi.org/10.3390/genes16050510.

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Objectives: To analyze potential associations between three polymorphisms (rs3818188, rs941793, rs2403015) of the DYNC1H1 gene and the occurrence of autism spectrum disorder as well as the clinical phenotype of affected individuals. Methods: This family-based study included 206 children diagnosed with ASD and 364 of their biological parents. To examine the potential association between three polymorphisms of the DYNC1H1 gene and ASD occurrence, a transmission disequilibrium test was performed. Additionally, associations between the studied polymorphisms and the clinical phenotype of affected i
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Cardoso, Jessica Vilarinho, Daniel Escorsim Machado, Renato Ferrari, Mayara Calixto da Silva, Plínio Tostes Berardo, and Jamila Alessandra Perini. "Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review." Revista Brasileira de Saúde Materno Infantil 16, no. 3 (2016): 219–32. http://dx.doi.org/10.1590/1806-93042016000300002.

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Abstract Objectives: to review studies that used case-control design to verify the association of polymorphisms in VEGF and KDR genes in the development of endometriosis. Methods: the systematic review selected articles published until September 1, 2015 from PubMed, MEDLINE, BVS, SciELO databases, considering the following key words: endometriosis and ("polymorphism" or "SNP" or "genetic polymorphism") and ("VEGF" OR "Vascular endothelial growth factor" or "VEGFR-2" or "Vascular endothelial growth factor-2" or "KDR" or "Kinase Insert Domain Receptor"). Results: 106 articles were identified, on
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5

Rył, Aleksandra, Natalia Tomska, Anna Jakubowska, Alicja Ogrodniczak, Joanna Palma, and Iwona Rotter. "Genetic Aspects of Problematic and Risky Internet Use in Young Men—Analysis of ANKK1, DRD2 and NTRK3 Gene Polymorphism." Genes 15, no. 2 (2024): 169. http://dx.doi.org/10.3390/genes15020169.

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Background: Internet addiction disorder (IAD) is characterized by an excess of uncontrolled preoccupations, urges, or behaviors related to computer use and Internet access that culminate in negative outcomes or individual distress. PIU includes excessive online activities (such as video gaming, social media use, streaming, pornography viewing, and shopping). The aim of this study was to analyze the association of gene polymorphisms that may influence the severity of risky behaviors in young men with the frequency of Internet use. We speculate that there are individual differences in the mechan
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M. khadhim, Manal, Ali T. AL-Damerchi, and Meraim A. Kazaal. "Evaluation of A Disintegrin and Metalloprotein33 Gene Polymorphism in Bronchial Asthma." AL-QADISIYAH MEDICAL JOURNAL 11, no. 19 (2017): 1–9. http://dx.doi.org/10.28922/qmj.2015.11.19.1-9.

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Background: A disintegrin and metalloprotein 33 (ADAM33) gene is the first asthma candidate gene identified by positional cloning, may be associated with lung function decline and bronchial hyperresponsiveness. However, replication results have been inconclusive in smaller previous study populations probably due to inconsistence in asthma phenotypes or yet unknown environmental influences. This study aimed to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of our case- control. Materials and methods: One polymorphic sites (V4) of ADAM33 gene was genotyped in 69
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Chalwe, Joseph Musonda, Christa Johanna Grobler, and Wilna Hendrika Oldewage-Theron. "Correlation of Eight (8) Polymorphisms and Their Genotypes with the Risk Factors of Cardiovascular Disease in a Black Elderly Population." Current Issues in Molecular Biology 46, no. 11 (2024): 12694–703. http://dx.doi.org/10.3390/cimb46110753.

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Single nucleotide polymorphisms (SNPs) have been associated with the development of cardiovascular diseases (CVDs). This study correlated eight SNPs with the risk factors of CVD in a black elderly population. Genotyping was used to detect eight polymorphisms; rs675 (ApoA-IV), rs699 (Angiotensinogen (AGT)), rs247616 and rs1968905 (Cholesteryl ester transfer protein (CETP)), rs1801278 (Insulin receptor substrate 1 (IRS-1)), rs1805087 (Methylenetetrahydrofolate reductase (MTHFR)) and rs28362286 and rs67608943 (Proprotein convertase subtilisin/kexin type 9 (PCSK9)), as well as their genotypes in d
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Guo, Lei, Yanan Liu, Lijun Liu, et al. "The CYP19A1 (TTTA)n Repeat Polymorphism May Affect the Prostate Cancer Risk: Evidence from a Meta-Analysis." American Journal of Men's Health 15, no. 3 (2021): 155798832110170. http://dx.doi.org/10.1177/15579883211017033.

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Abnormal aromatase (CYP19A1) expression may participate in prostate cancer (PCa) carcinogenesis. However, the results of studies on the CYP19A1 gene polymorphisms and PCa are conflicting. This meta-analysis aimed to systematically evaluate the associations between the CYP19A1 Arg264Cys polymorphism and the (TTTA)n repeat polymorphism and PCa. Electronic databases (PubMed, EmBase, ScienceDirect, and Cochrane Library) were comprehensively searched to identify eligible studies. The strength of the association between the Arg264Cys polymorphism and PCa was assessed by pooled odds ratios (ORs) and
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Maliza, Rita, Lalu Muhammad Irham, Jaka Pradika, et al. "Genetic polymorphism and the risk of diabetic foot: a bibliometric analysis from 2011-2021." International Journal of Public Health Science (IJPHS) 12, no. 4 (2023): 1744. http://dx.doi.org/10.11591/ijphs.v12i4.23028.

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Diabetic foot ulcer (DFU) has been associated with genetic and environmental factors, which could potentially have a role in DFU development. Single nucleotide polymorphisms (SNPs) in genes linked to DFU, including inflammation. Bibliometric studies on the SNP on genes affecting DFU still have not been evaluated. This study aims to depict bibliographically and understand the topic trend of genetic polymorphism and the risk of DFU publications. A bibliometric methodology was applied in this study. The data were extracted through the Scopus database from 2011 to 2021. VOS viewer was used to clas
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Wang, Tzu-Yun, Sheng-Yu Lee, Yi-Lun Chung, et al. "TPH1 and 5-HTTLPR Genes Specifically Interact in Opiate Dependence but Not in Alcohol Dependence." European Addiction Research 22, no. 4 (2016): 201–9. http://dx.doi.org/10.1159/000444676.

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Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a p
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Tesi sul tema "Polymorphisme social"

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Taupenot, Antoine. "Implication de supergènes dans l'expression de traits complexes chez la fourmi socialement et morphologiquement polymorphe Myrmecina graminicola." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS201.pdf.

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Les supergènes, des régions génétiques où des loci coadaptés sont transmis comme une seule unité mendélienne, jouent un rôle crucial dans la mise en place des polymorphismes complexes mais démêler la complexité de leur évolution et de leur maintien reste un défi de taille. Les fourmis offrent un contexte unique pour mettre en évidence de nouveau supergènes et étudier les principes généraux régissant leur mise en place et leur évolution puisqu'elles présentent de grandes variations inter et intra-espèces dans tous les aspects de leur organisation sociale et qu'un nombre inhabituellement élevé d
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Philippe, Anne-Sophie. "Etude de la variation génétique et de la plasticité des comportements sociaux chez la drosophile." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112089/document.

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La variation des comportements sociaux est une problématique très importante pour appréhender l’évolution de la socialité dans le règne animal. Par l’étude des interactions entre les paramètres génétiques et environnementaux sur les comportements sociaux de la drosophile (Drosophila melanogaster), cette thèse s’inscrit dans cette problématique et cherche à mettre en évidence les paramètres déterminants pour la expliquer la variation des comportements sociaux des individus. Au cours de ce travail de recherche, on a pu étudier et mettre en évidence l’existence de comportements sociaux chez la dr
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Sanchez, Sylvie. "Une séduction transculturelle : la pizza : polymorphisme, appropriation et identité dans l'alimentation." Paris, EHESS, 2002. http://www.theses.fr/2002EHES0125.

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La pizza a connu au vingtième siècle une diffusion quasi-universelle. Devenue aux Etats-Unis l'une des nourritures les plus familières, elle vient aujourd'hui sous ses formes américanisées réinvestir l'Europe et conquérir les autres continents. La vicariance de ce mets à travers les cultures et les grammaires culinaires les plus diverses en fait une voie royale pour explorer les modalités du contact interculturel, identifier les conditions de l'emprunt mutuel, de l'appropriation ou de la réappropriation. L'analyse montre que, quel que soit le vecteur d'introduction du " nouveau ", industriel o
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Pigeyre, Marie. "Etude des déterminants du comportement alimentaire : interaction gène-environnement dans l'obésité." Lille 2, 2010. http://www.theses.fr/2010LIL2S019.

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La prévalence de l'obésité a considérablement augmenté au cours des dernières décennies et est généralement expliquée par l'interaction entre les changements environnementaux et la prédisposition génétique. Le premier objectif était d’examiner l'impact des changements socioprofessionnels et éducatifs sur la prévalence de l'obésité en France. Cette analyse a été effectuée dans la population MONICA (5423 hommes et 5271 femmes âgés de 35 à 64 ans) en 1986, 1996 et 2006 dans trois régions géographiques de la France. Un questionnaire et un examen clinique standardisé ont permis de recueillir les do
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Colliat, Rémi. "Intégration économique européenne et système fiscal décentralisé : darwinisme institutionnel ou émergence d'un polymorphisme fiscal ?" Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00873528.

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L'objectif de ce travail est d'analyser l'impact de l'intégration européenne sur les systèmes nationaux de politiques fiscales. La concurrence fiscale internationale, inhérente à l'internationalisation croissante des économies, induit une course au moins disant fiscal. Ce type de stratégies, que nous nommons " darwinisme institutionnel ", pose la question de la convergence des systèmes fiscaux vers un modèle unique non satisfaisant pour chaque économie. C'est encore plus vrai à l'échelle de l'Union européenne : alors que les effets externes de l'intégration poussent, en théorie, à l'harmonisat
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Teboul, Annabelle. "Le polymorphisme du héros réaliste-naturaliste chez Balzac, Flaubert, Maupassant et Zola ou le parcours initiatique d'un être oxymorique." Phd thesis, Université de la Sorbonne nouvelle - Paris III, 2012. http://tel.archives-ouvertes.fr/tel-00935884.

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Ce travail de thèse interroge la représentation du héros au sein des mouvements réaliste et naturaliste du XIXe siècle. Il s'agit, au travers d'un corpus de six romans et nouvelles, de mettre en lumière la tension inhérente à la figure héroïque chez Honoré de Balzac, Gustave Flaubert, Guy de Maupassant et Émile Zola. Malgré un refus apparent du modèle classique antique qui se signe par une banalisation du personnage principal, les romanciers réalistes-naturalistes n'échappent finalement pas à la tentation héroïque; en proposant un parcours initiatique et des formes originales de sacralisation,
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Hahn, Patrick Daniel. "Social control of polymorphism in Zootermopsis." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185916.

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The sex-specific effects of reproductives and of soldiers on the reproductivity (i.e., tendency to develop into replacement reproductives) of pseudergates of Zootermopsis nevadensis were studied. Reproductives inhibit reproductivity in pseudergates of their own sex only. Reproductives neither inhibit nor stimulate reproductivity in pseudergates of the opposite sex. Reproductives do not require the presence of a reproductive of the opposite sex to stimulate them to inhibit reproductivity in pseudergates. Soldiers had no effect on the reproductivity of pseudergates. The effects of group size and
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Davison, Paul James. "Social polymorphism and social behaviour in sweat bees (Hymenoptera: Halictidae)." Thesis, University of Sussex, 2016. http://sro.sussex.ac.uk/id/eprint/61422/.

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I use field observations, experiments and molecular techniques to describe the social biology of the sweat bee Lasioglossum calceatum, and to investigate the mechanisms underlying social polymorphism and body size in this species. I also investigate environmental constraints on sociality, and the impact that workers have on productivity, in the obligate social species L. malachurum. Chapter 1 introduces sweat bees as a study system, and reviews social behaviour within the group. I then provide concise introductions to the study species. In Chapter 2 I show that L. calceatum exhibits latitudina
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Chiaroni, Jacques. "ETUDE ANTHROPOGENETIQUE DE LA POPULATION COMORIENNE DE MARSEILLE." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2003. http://tel.archives-ouvertes.fr/tel-00011766.

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La population actuelle de l'archipel des Comores est considérée comme étant le résultat de contacts entre des populations d'origine Africaine Bantoue, Arabe et Austronésienne. Le but de cette étude est de décrire sa structure génétique, au travers de l'analyse de six groupes sanguins érythrocytaires, du polymorphisme du locus HLA-DR-B1 et des gènes KIR. 164 individus, non apparentés, d'origine Comorienne résidant à Marseille ont été étudiés. Les résultats révèlent que la contribution génétique des populations originaires de l'Afrique Bantoue est la plus importante (50 à 60%) et est en accord a
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Ganem, Guila. "Commensalisme, fonction corticosurrénalienne et évolution chromosomique chez la souris domestique." Montpellier 2, 1991. http://www.theses.fr/1991MON20053.

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Ce travail s'integre dans une problematique generale cherchant a determiner quels aspects de l'environnement de la souris domestique peuvent participer a l'etablissement d'une divergence chromosomique (par suite de fixation de fusions robertsoniennes) dans certaines de ses populations. La souris domestique occupe deux types d'habitat exterieur et commensal. Le phenomene robertsonien est correle avec l'habitat commensal. Ici le commensalisme est considere dans ses aspects sociaux resultant des fortes densites et de la reproduction continue dans ce type d'habitat. La sensibilite des individus de
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Libri sul tema "Polymorphisme social"

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Kiaris, Hippokratis. Genes, polymorphisms, and the making of societies: How genetic behavioral traits influence human cultures. Universal-Publishers, 2012.

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Bhasin, M. K. People of India: An investigation of biological variability in ecological, ethno-economic, and linguistic groups. Kamla-Raj Enterprises, 1994.

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Westberg, Lars, and Hasse Walum. Oxytocin and Vasopressin Gene Variation and the Neural Basis of Social Behaviors. Edited by Turhan Canli. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199753888.013.011.

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Abstract (sommario):
Experimental studies in rodents and humans show that the neuropeptides oxytocin and vasopressin are important regulators of behaviors related to social interactions. Evidence for positive effects of oxytocin treatment on symptoms of psychiatric disorders characterized by impaired social functioning has emerged. Numerous studies report associations between various social behaviors, the risk of autism, and polymorphisms inOXTRandAVPR1A. This chapter provides an overview of these genetic association studies. Although many of the published findings are inconclusive and need replication in independ
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Kiaris, Hippokratis. Genes, Polymorphisms, and the Making of Societies: A Genetic Perspective of the Divergence Between East and West. Universal Publishers, 2021.

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Troisi, Alfonso. Detachment. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199393404.003.0003.

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Most of us find social encounters rewarding, especially when we encounter those with whom we are familiar and have built up a relationship. From an evolutionary point of view, this is not surprising; human beings are fundamentally social organisms, and human development and functioning occur within a social context. The origin of individual differences in the capacity to experience social reward is likely to involve a complex interplay of genetic and environmental variables, including genetic variation, early experience and current situational factors. A few individuals seem to lie at the lowe
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Gephart, Werner; Witte, ed. The Sacred and the Law: The Durkheimian Legacy. Klostermann, 2017. http://dx.doi.org/10.5771/9783465142942.

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There is little doubt about the importance of Emile Durkheim’s work and the influence it had on the social sciences. His insights into the realms of normativity in particular remain an inspiring mine of information for theoretical reflection and empirical analyses. While his strengths, as we know nowadays, might not have always laid in systematic arguments, his main concerns have shaped the development of social thought in fundamental ways: the question of changing social bonds and the problem of integration; belief and unbelief in societal values; acceptance and rejection of the law, obligati
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Burton, Derek, and Margaret Burton. Special adaptations. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198785552.003.0013.

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Within the considerable diversity of fish there are less-usual attributes of some species which facilitate survival in particular habitats or in response to selective pressures. The intense competition in warm, shallow water results in polymorphism in colour and size and complex social structure in some reef-fish and in different dentitions in cichlids with trophic specializations. Fish in the light-less deep sea are typically dark with large eyes and mouth; often they possess light-emitting photophores. In contrast, dark-dwelling cavefish lack melanin pigmentation, are usually pink, lack phot
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Fabbri, Chiara, and Alessandro Serretti. The treatment of bipolar disorder in the era of personalized medicine: myth or promise? Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0031.

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Bipolar disorder (BD) is a chronic disease associated with high personal and socio-economic burden. Genetics accounts for 20–95% of variability in central nervous system drug disposition and pharmacodynamics, thus genetic markers are considered a promising way to develop tailored treatments and improve the prognosis of the disease. Among mood stabilizers, lithium response was the most investigated phenotype and the most replicated genes are involved in synaptic plasticity (BDNF), serotonergic (SLC6A4) and dopaminergic (DRD1) neurotransmission, and second messenger cascades (GSK3B). Relevant ph
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Capitoli di libri sul tema "Polymorphisme social"

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Molet, Mathieu. "Worker Polymorphism." In Encyclopedia of Social Insects. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-90306-4_138-1.

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Molet, Mathieu. "Worker Polymorphism: Ants." In Encyclopedia of Social Insects. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-28102-1_138.

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Schmid-Hempel, Paul. "Infection and colony variability in social insects." In Infection, Polymorphism and Evolution. Springer Netherlands, 1997. http://dx.doi.org/10.1007/978-94-009-0077-6_5.

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da Silva, Marjorie, Sidnei Mateus, and Fernando Barbosa Noll. "Castes and Polymorphisms in Neotropical Social Wasps." In Neotropical Social Wasps. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-53510-0_6.

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Barany, Ernest. "Bifurcation as the Source of Polymorphism." In Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-03473-7_3.

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Roshani, O., M. Z. Mohd Syahril, and R. Mohd Hafiz. "Genetic Polymorphisms of Unicellular Green Algae Strains Using Random Amplified Polymorphic DNA." In Proceedings of the International Conference on Science, Technology and Social Sciences (ICSTSS) 2012. Springer Singapore, 2014. http://dx.doi.org/10.1007/978-981-287-077-3_75.

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Shia, J. S. K., Cannilia Kerine, K. L. Teh, et al. "Genotyping the Exon 10 of Low-Density Lipoprotein Receptor: Discovery of New Single Nucleotide Polymorphism." In Regional Conference on Science, Technology and Social Sciences (RCSTSS 2014). Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0534-3_54.

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Hussin, Siti Nooraishah, and John Kwong Siew Shia. "Screening of Adenomatous Polyposis Coli (APC) Gene Polymorphism Using Allele-Specific Polymerase Chain Reaction (ASPCR) Method." In Regional Conference on Science, Technology and Social Sciences (RCSTSS 2016). Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-13-0074-5_65.

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Armando León-Rodríguez, Diego, Julian Becerra, Juan Carlos Caicedo Mera, Luis Fernando Cardenas, Jorge Martínez Cotrina, and Diego Mauricio Aponte Canencio. "OXTR Gene Polymorphisms and Event-Related Potentials in Humans: A Systematic Review." In Oxytocin and Social Function. IntechOpen, 2024. http://dx.doi.org/10.5772/intechopen.112631.

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Abstract (sommario):
Oxytocin receptor (OXTR) gene polymorphisms have been consistently associated with humans’ differences in sensitivity to social cues, social cognition, stress response, and brain activity. However, how social and affective neural processing differs across carriers of distinct OXTR gene polymorphisms remains unclear. This systematic PRISMA review is the first to examine the experimental literature on the relationship between OXTR polymorphisms and ERP components. Eight studies published between 2014 and 2019 were included. The rs53576 was the only OXTR gene polymorphism analyzed in all studies. The OXTR genetic variation explained significant changes in N1, P2, N2, P3, and late positive potential (LPP) components during social perception and empathy for pain tasks. OXTR genotypes were not related to P1, N170, N3, or any neural activity after 600 ms. The discussion is focused on the influence of OXTR genetics on neural processing, the development of brain neural networks implicated in social and emotional skills, cultural neuroscience of the oxytocinergic system, and methodological issues of this field. In conclusion, the evidence supports the hypothesis that genetic variations of the OXTR significantly influence neural activity related to emotional and social processing, except for the early phases of face recognition.
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Bandazheuski, Yuri, and Nataliia Dubovaya. "ELEMENTS OF ETIO-PATHOGENESIS OF HYPERHOMOCYSTEINEMIA IN CHILDREN LIVING IN THE REGIONS AFFECTED FROM THE ACCIDENT AT THE CHERNOBYL NUCLEAR POWER PLANT." In The scientific paradigm in the context of technological development and social change. Publishing House “Baltija Publishing”, 2023. http://dx.doi.org/10.30525/978-9934-26-297-5-25.

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The prevalence of hyperhomocysteinemia in the population of children living in the area affected by the accident at the Chernobyl Nuclear Power Plant (ChNPP) requires a deep study of the etio-pathogenesis of metabolic disorders of the sulfur-containing amino acids methionine (Met) and homocysteine (Hcy) under radiation exposure. The purpose of the study was to assess the involvement of genetic (folate cycle polymorphisms – FC) and environmental factors in the occurrence of hyperhomocysteinemia in boys and girls living in the Ivankovsky and Polessky districts of the Kyiv region of Ukraine, near the Chernobyl Exclusion Zone (ChEZ). The methodology of the study is based on the evaluation by statistical methods of the results of genetic and laboratory examinations of 690 children (368 girls and 322 boys), aged 8-17 years, obtained in the course of projects of the European Commission, the Regional Council of Rhone-Alpes (France) and the French public organization "Children Chernobyl". It has been shown that in most cases, the violation of Hcy metabolism and the occurrence of hyperhomocystinemia in children from areas affected by the Chernobyl accident are caused by the association of genotypes with risk alleles of MTHFR:C677T and MTRR:A66G polymorphisms. Given the wide prevalence in the population, combinations of their heterozygous forms are of the greatest importance.The risk allele G of the MTRR:66 polymorphism also has a negative effect on the processes of Hcy methylation when associated with the risk allele G of the MTR:A2756G polymorphism and with compound heterozygosity A/CMTHFR:1298 – C/TMTHFR:677. In the body of boys, compared with the body of girls, combinations of risk alleles for FC polymorphisms are manifested by a more pronounced disturbance of Hcy metabolism. The A/AMTRR:66 genotype promotes Hcy utilization in the transsulfuration cycle, even if only one C allele of the MTHFR:677 polymorphism functions.An external environmental factor in the form of radioactive agents incorporated into vital organs, undermining cellular energy, has a negative impact on the processes of cobalamin methylation. The consequence of this is the occurrence of a state of hyperhomocysteinemia in more than 50 % of boys and girls who do not have risk alleles of MTR:A2756G, MTHFR:C677T and MTRR:A66G polymorphisms in the genome. Conclusions. The main internal cause of hyperhomocysteinemia in children living near the ChEZ is the association of risk alleles for FC genetic polymorphisms.The combined effect of endogenous (genetic mutations of FC) and exogenous (radioactive elements, their decay products, substances formed during the combustion of wood) factors leads to disruption of the Hcymethylation process and the emergence of a state of hyperhomocysteinemia in children living in the territory affected by the Chernobyl accident. This type of metabolic disorder can be considered a distant consequence of the Chernobyl accident. Further research should be aimed at developing measures for the prevention and treatment of hyperhomocysteinemia, as a condition associated with the occurrence of serious pathological processes.
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Atti di convegni sul tema "Polymorphisme social"

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Ergashevna, Abidova, Muhamedova Gafurjanovna, and Mullabayeva Uchkunona. "Genetic Aspects of Arterial Hypertension: How Gene Polymorphisms Determine the Risk of Developing Hypertension." In The International Conference on Humanities Education, Law, and Social Science. SCITEPRESS - Science and Technology Publications, 2024. https://doi.org/10.5220/0013424600004654.

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Соловьева, А. Д., Н. В. Бардуков, and В. Р. Харзинова. "MITOCHONDRIAL DNA POLYMORPHISM IN DOMESTIC AND WILD REINDEER." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии. Crossref, 2021. http://dx.doi.org/10.48397/arriab.2021.21.xxi.014.

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Северный олень (Rangifer tarandus) имеет важнейшее экономическое, социальное, культурное и экологическое значение для коренных малочисленных народов. Олени являются источником мяса, шкур, а иногда и молока, и их используют в качестве транспортных средств. The reindeer (Rangifer tarandus) is of major economic, social, cultural and environmental importance to indigenous peoples. Reindeer are a source of meat, skins, and sometimes milk, and are used as vehicles.
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Mohd Nazif Samat Darawi, Chin Ai-Vyrn, Soraya Kunanayagam, et al. "Allele specific polymerase chain reaction for detection of the genetic polymorphism of NMDA receptor." In 2010 International Conference on Science and Social Research (CSSR). IEEE, 2010. http://dx.doi.org/10.1109/cssr.2010.5773888.

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Firdausi, Annisa, Rini Puspitaningrum, Chris Adhiyanto, Nurmasari Sartono, and Afifah izzati Afifah izzati. "Identification of Delta-Aminolevulinic Acid Dehydratase (ALAD) Gene Polymorphism in Students of Elementary School in Kalideres, Jakarta." In 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/ichlas-17.2017.17.

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Astaf'eva, E. A., T. A. Tolochko, and A. A. Timofeeva. "THE EFFECT OF POLYMORPHISM OF THE MTHFR C677T GENE ON THE MORPHOFUNCTIONAL STATE OF LYMPHOCYTES DURING DRUG INTOXICATION." In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-8.

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The prevalence of opioid dependence among the able-bodied population is an important
 medical and social problem. Methylenetetrahydrofolate reductase (MTHFR) plays a key role in the
 metabolism of narcotic drugs. A decrease in the enzyme activity in polymorphic variants of the
 gene encoding it is associated with a decrease in the immunity of opioid addiction patients.
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Saiz-Rodríguez, Miriam, Cecilia Gil-Polo, Mónica Diez-Fairen, et al. "F42 Polymorphisms in the oxytocin receptor and their association with apathy and impaired social cognition in Huntington’s disease." In EHDN 2022 Plenary Meeting, Bologna, Italy, Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jnnp-2022-ehdn.133.

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Bolatkhan, Makhatov, Gulzhan Mussayeva, Gulshat Shaikamal, Indira Beishova, and Jan Micinski. "Early diagnosis of the causes of Holstein cows’ extinction by polymorphisms BGH-ALUI and BIGF-1-SNABI." In PROCEEDINGS OF THE 2ND INTERNATIONAL INTERDISCIPLINARY SCIENTIFIC CONFERENCE “DIGITALIZATION AND SUSTAINABILITY FOR DEVELOPMENT MANAGEMENT: ECONOMIC, SOCIAL, AND ENVIRONMENTAL ASPECTS”. AIP Publishing, 2024. http://dx.doi.org/10.1063/5.0192640.

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Syarifah, Siti, Dita Hasni, Tri Widyawati, and Dwi Rita Anggraini. "The Association of G2677T Polymorphism in MDR1 Gene with Neutropenia Incidence in Breast Cancer Patients Treated by Doxorubicin based Chemotherapy." In 3rd International Conference of Computer, Environment, Agriculture, Social Science, Health Science, Engineering and Technology. SCITEPRESS - Science and Technology Publications, 2018. http://dx.doi.org/10.5220/0010044204280431.

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Rahayu, Dwi, Ratih D. Yudhani, Ratna Kusumawati, and Dono Indarto. "Iron Deficiency is The Main Cause of Anemia in Female Students of Secondary Schools in Sukoharjo Regency with No Polymorphism of Transferrin Receptor 1." In 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/ichlas-17.2017.41.

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Ramadhan, Moch Rizki, Chris Adhiyanto, and Zeti Harriyati. "Identification of Delta-Aminolevulinic Acid Dehydratase (ALAD) Gene Polymorphism and Its Association with Anemia in Medical Study Programs and Doctor Profession 2012-2014 Syarif Hidayatullah State Islamic University." In 1st International Integrative Conference on Health, Life and Social Sciences (ICHLaS 2017). Atlantis Press, 2017. http://dx.doi.org/10.2991/ichlas-17.2017.19.

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Rapporti di organizzazioni sul tema "Polymorphisme social"

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Zhao, Zepeng, Fengyuan Zhang, and Yijin Li. The Relationship Between Il-1 RN intron 2 (VNTR) rs2234663 Gene Polymorphism and The Progression of Periodontitis: A systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.3.0100.

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Review question / Objective: The aim of this systematic review and meta-analysis of case-control studies is to find out the association of IL-1 RN intron 2 (VNTR) rs2234663 Gene Polymorphism and the occurrence and progression of periodontitis(including chronic periodontitis, aggressive periodontitis and early-onset periodontitis). Condition being studied: Periodontitis is one of the most common ailments affecting the teeth, leading to the destruction of the supporting and surrounding tooth structure. Periodontitis is originally a disease originating from the gingival tissue which if left untre
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