Accedi

Bibliografie tematiche / POTENTIAL INHIBITORS

Indice

Articoli di riviste
Tesi
Libri
Capitoli di libri
Atti di convegni
Rapporti di organizzazioni

Letteratura scientifica selezionata sul tema "POTENTIAL INHIBITORS"

Autore: Grafiati

Pubblicato: 26 ottobre 2023

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Consulta la lista di attuali articoli, libri, tesi, atti di convegni e altre fonti scientifiche attinenti al tema "POTENTIAL INHIBITORS".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Articoli di riviste sul tema "POTENTIAL INHIBITORS"

1

Lechner, Christian, Maren Flaßhoff, Hannes Falke, Lutz Preu, Nadége Loaëc, Laurent Meijer, Stefan Knapp, Apirat Chaikuad e Conrad Kunick. "[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors". Molecules 24, n. 22 (13 novembre 2019): 4090. http://dx.doi.org/10.3390/molecules24224090.

Testo completo

Abstract (sommario):

Since hyperactivity of the protein kinase DYRK1A is linked to several neurodegenerative disorders, DYRK1A inhibitors have been suggested as potential therapeutics for Down syndrome and Alzheimer’s disease. Most published inhibitors to date suffer from low selectivity against related kinases or from unfavorable physicochemical properties. In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were designed, synthesized, and evaluated for biological activity. Analysis of crystal structures revealed a typical type-I binding mode of the new inhibitor 4-chlorocyclohepta[b]indol-10(5H)-one in DYRK1A, exploiting mainly shape complementarity for tight binding. Conversion of the DYRK1A inhibitor 8-chloro-1,2,3,9-tetrahydro-4H-carbazol-4-one into a corresponding Mannich base hydrochloride improved the aqueous solubility but abrogated kinase inhibitory activity.

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Sharma, Manish Kumar, Anil Kumar Sharma e S. P. Mathur. "Solanum surrattence as Potential Corrosion Inhibitor". ISRN Corrosion 2012 (28 agosto 2012): 1–5. http://dx.doi.org/10.5402/2012/907676.

Testo completo

Abstract (sommario):

Developping chip and ecofriendlly corrosion inhibitors can replace toxic chemicals which are currently used in industries. Plant extract of Solanum surrattence in acetone, petroleum ether, and methanol has been tasted using mass loss and thermometric measurements for corrosion of aluminium in acid solutions. The plant extract of Solanum surrattence is a good corrosion inhibitor for aluminium. The inhibition efficiency depends upon the concentration of inhibitors, it inhibits the metal of 97.60% at its maximum value. This inhibitor shows efficiency at 25°C. At higher temperature the inhibition efficiency decreases. These types of inhibitors can be used to replace the toxic chemicals which are currently used in industries. We find out cheap and ecofriendlly corrosion inhibitors which can be used by acid, petrochemical, and chemical industries.

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Samsudin, Sity Juaeiriah, Nurlidia Binti Mansor, Suriati Sufian e Zakaria B. Man. "The Potential of Garlic Extract as Bio-Inhibitor in Urea Fertilizer". Key Engineering Materials 594-595 (dicembre 2013): 296–300. http://dx.doi.org/10.4028/www.scientific.net/kem.594-595.296.

Testo completo

Abstract (sommario):

Urea is extensively used as fertilizer in the agricultural industry based on its suitability for all types of crops. The hydrolysis of urea fertilizer produces ammonia (NH3) and carbon dioxide (CO2). However, up to 40% of NH3 release affects the efficiency of urea fertilizer. By introducing inhibitors into the urea enzymatic reaction, the NH3 emission problem can be solved. Unfortunately, current inhibitors are usually chemical based and non-biodegradable. Several complaints and accidents have been reported when handling chemical based inhibitors especially for surface application. Research on garlic or Allium savatium has been conducted to ensure its inhibitory effects as potentially safe and biodegradable inhibitor. From previous research, thiosulfinates (TS) contained in garlic extract proved to inhibit platelets aggregation in medical applications. In this study, the inhibitory effect is determined by analyzing NH3 concentration in urease-garlic mixture and standard urea assay mixtures using UV-VIS spectrophotometer device. Previous research showed the highest absorbance of free NH3 was detected at 370nm. At 30 minutes of 15ml of urease-garlic mixture confirms the fully inhibition of garlic extract towards reaction.

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Buolamwini, John K. "Nucleoside Transport Inhibitors: Structure-Activity Relationships and Potential Therapeutic Applications". Current Medicinal Chemistry 4, n. 1 (febbraio 1997): 35–66. http://dx.doi.org/10.2174/0929867304666220309201038.

Testo completo

Abstract (sommario):

A survey of structure-activity relationships and potential therapeutic applications of nucleoside transport inhibitors is presented. Among the two equilibrative (facilitated diffusion), and five concentrative (sodium-dependent) nucleoside transporters identified in mammalian cells, only the equilibrative transporters (es and e1) and one concentrative transporter (cs) can be effectively blocked by one or more of the nucleoside transport inhibitors discovered to date. A structurally diverse array of compounds have been shown to exert nucleoside transport inhibitory activity to varying degrees. The most important of these are i) nucleoside analogs of which s6-(4-nitrobenzyl)mercaptopurine riboside (NBMPR, nitrobenzylthioinosine) is the prototype, ii) pyrimidopyrimidine and pteridine derivatives of which dipyridamole (Persantine) is the prototype, and iii) alkyl- and cycloalkyldiamine and piperazine calcium channel antagonists of which dilazep and lidoflazine are the representatives, respectively. All of these are effective inhibitors of the es transporter, but dipyridamole is also a potent inhibitor of the ei transporter with variable activity depending on the cell type. Surprisingly, NBMPR and dipyridamole are also potent inhibitors of the newly identified cs concentrative transporter in fresh leukemia cells from patients. Not only does the es inhibitory potency of these compounds depend on tissue type, but it also varies widely among different mammalian species. <p> Nucleoside transport inhibitors have potential for therapeutic uses in 1) adenosine potentiation in cardioprotection and cerebroprotection in ischemic heart disease and stroke, respectively, 2) the modulation of the effects of antimetabolite anticancer and antiviral agents, and 3) host tissue protection in chemotherapy with cytotoxic nucleosides. Additional areas of potential therapeutic application of NT inhibitors include kidney transplantation, analgesia and hypertension. Most of the compounds in the present repertoire of potent NT inhibitors do not meet the requisite pharmacological profiles for successful clinical application, which calls for the discovery of better inhibitors. Advances are being made in the molecular cloning and functional expression of nucleoside transporters that augur well for future drug design efforts. </p>

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Chen, Xingchen, Darren Leahy, Jessica Van Haeften, Perry Hartfield, Peter J. Prentis, Chloé A. van der Burg, Joachim M. Surm et al. "A Versatile and Robust Serine Protease Inhibitor Scaffold from Actinia tenebrosa". Marine Drugs 17, n. 12 (12 dicembre 2019): 701. http://dx.doi.org/10.3390/md17120701.

Testo completo

Abstract (sommario):

Serine proteases play pivotal roles in normal physiology and a spectrum of patho-physiological processes. Accordingly, there is considerable interest in the discovery and design of potent serine protease inhibitors for therapeutic applications. This led to concerted efforts to discover versatile and robust molecular scaffolds for inhibitor design. This investigation is a bioprospecting study that aims to isolate and identify protease inhibitors from the cnidarian Actinia tenebrosa. The study isolated two Kunitz-type protease inhibitors with very similar sequences but quite divergent inhibitory potencies when assayed against bovine trypsin, chymostrypsin, and a selection of human sequence-related peptidases. Homology modeling and molecular dynamics simulations of these inhibitors in complex with their targets were carried out and, collectively, these methodologies enabled the definition of a versatile scaffold for inhibitor design. Thermal denaturation studies showed that the inhibitors were remarkably robust. To gain a fine-grained map of the residues responsible for this stability, we conducted in silico alanine scanning and quantified individual residue contributions to the inhibitor’s stability. Sequences of these inhibitors were then used to search for Kunitz homologs in an A. tenebrosa transcriptome library, resulting in the discovery of a further 14 related sequences. Consensus analysis of these variants identified a rich molecular diversity of Kunitz domains and expanded the palette of potential residue substitutions for rational inhibitor design using this domain.

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Žbulj, Katarina, Gordana Bilić, Lidia Hrnčević e Katarina Simon. "Potential of using plant extracts as green corrosion inhibitors in the petroleum industry". Rudarsko-geološko-naftni zbornik 36, n. 5 (2021): 132–39. http://dx.doi.org/10.17794/rgn.2021.5.12.

Testo completo

Abstract (sommario):

In this paper, preliminary studies of ten different plant extracts as potential corrosion inhibitors of carbon steel were examined. For each extract, the concentration range in which it shows anti-corrosion action was first determined, and then the most effective concentration was determined for each extract. The tests were performed in a brine solution saturated with CO2 at room temperature. The aim of this study was to isolate extracts with high effectiveness and subsequent electrochemical and surface methods to determine the mechanism of inhibitory action. For this purpose, potentiodynamic polarization was performed with Tafel extrapolation. Among all the tested extracts, lady’s mantle (92.17%) and dandelion root (95.07%) stood out with their effectiveness. Both tested extracts showed the behaviour of a mixed corrosion inhibitor with a dominant influence on the anode process.

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Serio, Rosa, Flavia Mulé e Alessandra Postorino. "Noradrenergic, noncholinergic inhibitory junction potentials in rat proximal colon: role of nitric oxide". Canadian Journal of Physiology and Pharmacology 73, n. 1 (1 gennaio 1995): 79–84. http://dx.doi.org/10.1139/y95-011.

Testo completo

Abstract (sommario):

Using a single sucrose gap apparatus, experiments were performed to determine the involvement of nitric oxide (NO) in the generation of noradrenergic, noncholinergic (NANC) inhibitory junction potentials in circular muscle of rat proximal colon. Inhibitors of NO synthase, Nω-nitro-L-arginine and its methyl ester, reduced the amplitude of the electrically evoked inhibitory junction potentials, without affecting membrane resting potential. Such an effect was stereospecific and it was prevented by L-arginine but not by D-arginine. Sodium nitroprusside induced a tetrodotoxin-resistant hyperpolarization, which was not affected by NO synthase inhibitors. Aparnin reduced sodium nitroprusside induced hyperpolarization, as well as NANC inhibitory junction potentials, and α-chymotrypsin decreased the amplitude of electrical field stimulation evoked responses. Residual responses after NO synthase inhibitors or after α-chymotrypsin were further reduced by pretreatment with α-chymotrypsin or NO synthase inhibitors, respectively. These results suggest that, in rat colonic circular muscle, NO plays an important role in NANC inhibitory junction potential generation. However, another mechanism, peptidergic in nature, is also involved.Key words: nonadrenergic noncholinergic nerves, inhibitory junction potential, nitric oxide, rat colon.

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Sliskovic, Drago R., e Bharat K. Trivedi. "ACAT Inhibitors: Potential Anti-atherosclerotic Agents". Current Medicinal Chemistry 1, n. 3 (ottobre 1994): 204–55. http://dx.doi.org/10.2174/092986730103220214163743.

Testo completo

Abstract (sommario):

Abstract: The evolution of ACAT inhibitors •from purely hypocholestero lemic agents to potential anti-atherosclerdtic agents has occurred only recently.A large number of structurally diverse ACAT inhibitors were initially developed as hypocholesterolemic agets whose prime mechanism of action was inhibition of dietary cholesterol absorption in the intestine, however, efficacy for such non-absorbable agents, in humans, has remained elusive. Esterification of cholesterol within the hepatocyte has been shown to be required for VLDL synthesis and secretion, and inhibition of ACAT within the artery wall may prove to be the "ultimate" anti-atherosclerotic mechanism by preventing the formation of cholesterol ester loaded macrophages (foam cells), the precursors of the fatty streak, an early lesion in the atherosclerotic process. Thus, more recently, there has been a concerted effort to design more bioavailable inhibitors capable of inhibiting the enzyme in the liver and artery wall. Displaying direct efficacy at the artery wall for an ACAT inhibitor has been complicated by the fact that in pre-clinical animal models, it has been difficult to dissociate the effects of lipid lowering from a true direct effect at the artery wall. Recently, a novel ACAT inhibitor, Cl-976, has been disclosed which displays anti-atherosclerotic activity in an injured cholesterol fed rabbit model of atherosclerosis without exhibiting a cholesterol lowering effect.The SAR around Cl-976 and related series will be discussed and placed in context with other novel structural types of ACAT inhibitors appearing in the recent literature.

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Robina, Inmaculada, Antonio Moreno-Vargas, Ana Carmona e Pierre Vogel. "Glycosidase Inhibitors as Potential HIV Entry Inhibitors?" Current Drug Metabolism 5, n. 4 (1 agosto 2004): 329–61. http://dx.doi.org/10.2174/1389200043335513.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Evans, Tarra, e Ursula Matulonis. "PARP inhibitors in ovarian cancer: evidence, experience and clinical potential". Therapeutic Advances in Medical Oncology 9, n. 4 (3 febbraio 2017): 253–67. http://dx.doi.org/10.1177/1758834016687254.

Testo completo

Abstract (sommario):

Inhibitors of poly(ADP-ribose) polymerase (PARP) are considered one of the most active and exciting new therapies for the treatment of ovarian cancer. The anticancer activity of PARP inhibitors is based on the DNA repair vulnerability of many ovarian cancer cells, and multiple mechanisms of action of PARP inhibitors have been identified. As single agents, PARP inhibitors have demonstrated their greatest activity in ovarian cancer cells that harbor mutations in BRCA genes. Additionally, recent phase III studies have shown that single-agent PARP inhibitor activity extends beyond BRCA-related cancers and can benefit patients with ovarian cancers that do not have known BRCA mutations, especially when clinical characteristics such as platinum sensitivity and high-grade serous histology are present. PARP inhibitors have also been combined with chemotherapy, however, overlapping myelosuppression observed with PARP inhibitor and chemotherapy combinations has hampered development of these combinations. Contrariwise, PARP inhibitor and biologic agent combinations, specifically antiangiogenic agents, appear well tolerated and show promising activity in both BRCA mutated ( BRCAm) and BRCA wild-type ( BRCAwt) cancers. Currently, multiple clinical trials are underway examining the antitumor activity of PARP inhibitor combination therapy.

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Tesi sul tema "POTENTIAL INHIBITORS"

1

Anson, T. C. "Synthesis of potential enzyme inhibitors". Thesis, University of Exeter, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372033.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Bichard, Claire J. F. "Synthesis of potential glycogen phosphorylase inhibitors". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260115.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Chong, Sannie Siaw Foong. "Anisotropic potential HIV-1 protease inhibitors". Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327289.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Dhanani, Sachin Paryantray. "Biochemical evaluation of potential enzyme inhibitors". Thesis, Kingston University, 2006. http://eprints.kingston.ac.uk/20375/.

Testo completo

Abstract (sommario):

A high proportion of prostate cancer and benign prostatic hyperplasia (BPH) have been shown to be dependent on androgen biosynthesis. The biosynthesis of androgens is undertaken by a number of important enzymes such as 17a-hydroxylase/17,20-lyase and 17[beta]-hydroxysteroid dehydrogenase. Through the inhibition of these enzymes it is possible to. reduce the amount of androgens present, which in turn reduces the stimulation of androgen-dependent prostatic diseases. Within the current study, we have undertaken the biochemical evaluation of a number of compounds of varying structural features and which were synthesised within our group as potential enzyme inhibitors in the tretament of androgen-dependent diseases. In general, the results from the current study show that the compounds evaluated against the enzyme complex 17a-hydroxylase/17,20-lyase possessed good inhibitory activity. In particular, the imidazole-based inhibitors were found to be more potent against 17,20-lyase in comparison to 17a-hydroxylase, and were more potent than the triazole-based compounds. The most potent compounds within the current study include: 1-(7-phenyl-heptyl)-1H-imidazole (171) (lC50=98.5±15.6nM, K¡=55.3±3AnM against 17,20-lyase and IC50=O.32±O.05I-lM, K¡=O.21±O.01¡.¡M against 17a-hydroxylase), 1-[7 -(4-fluoro-phenyl)-heptyl]-1 H-imidazole (179) (IC50=57.5±1.5nM, K¡=21.5±O.1nM against 17,20-lyase and IC50=173.62±7.00nM, K¡=77.5±2.5nM against 17 a-hydroxylase) and 1-[5-(4-bromo-phenyl)-pentyl]-1 H-imidazole (187) (IC50=58.1±5.2nM against 17,20-lyase and IC50=O.50±O.04I-lM against 17a-hydroxylase), these compounds were all potent inhibitors compared to the standard inhibitor ketoconazole (1) (lC50=1.66±O.15¡.JM, K¡=O.67±O.02¡.¡M against 17,20-lyase and IC50=3.76±O.01I-lM, K¡=1.24±O.01¡.¡M against 17a-hydroxylase). In an effort to discover lead compounds in the inhibition of the 17[beta]-hydroxysteroid dehydrogenase (17[beta]-HSD) family of enzymes, a range of commercially available compounds based on phenyl ketones were initially evaluated against type 1 (17[beta]-HSD1) and 3 (17[beta]-HSD3) of 17[beta]-HSD which are responsible for the reduction of estrone and androstenedione to estradiol and testosterone respectively. The majority of these compounds were found to possess weak inhibitory activity, however, some were found to possess good inhibitory activity. As such, a number of compounds were synthesised within our group as potential inhibitors of 17[beta]-HSD1 and 17[beta]-HSD3. The results show that the 4-hydroxyphenyl ketone-based compounds were found to be . highly potent against type 3 in comparison to type 1. For example, 1-(4-hydroxy-phenyl)-nonan-1-one (254) was found to possess (against type 3) inhibitory activity of 83.53±OA8% (at [1]=100¡.¡M) (IC5o of 2.86 ± O.03¡.¡M). Under similar conditions, 254 was found to possess 36.32±O.33% (at [1]=100¡.¡M) inhibitory activity against type1. A range of compounds were also synthesised based on the biphenyl ketones, however, these were found to be weaker inhibitors of type 3 in comparison to the 4- hydroxyphenyl ketones although they possessed greater inhibitory activity against type 1. In an effort to determine the selectivity of these compounds against the overall class of HSD enzymes, all inhibitors were evaluated for 3[beta]-hydroxysteroid dehydrogenase (3[beta]-HSD) inhibitory activity. We discovered that in general, all of the synthesised compounds possessed weak inhibitory activity against this enzyme at inhibitor concentration of 100¡.¡M and 500¡.¡M, as such, these synthesised compounds could be considered to be good lead compounds for the inhibition of 17[beta]-HSD.

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Casey, Lorraine A. "The synthesis of potential enzyme inhibitors". Thesis, University of Huddersfield, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290421.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Haddow, J. "Potential suicide inhibitors of dihydrofolate reductase". Thesis, University of Strathclyde, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381497.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Abdeen, Sanofar, Nilshad Salim, Najiba Mammadova, Corey M. Summers, Rochelle Frankson, Andrew J. Ambrose, Gregory G. Anderson et al. "GroEL/ES inhibitors as potential antibiotics". Elsevier, 2016. http://hdl.handle.net/10150/618724.

Testo completo

Abstract (sommario):

We recently reported results from a high-throughput screening effort that identified 235 inhibitors of the Escherichia coli GroEL/ES chaperonin system [Bioorg. Med. Chem. Lett. 2014, 24, 786]. As the GroEL/ES chaperonin system is essential for growth under all conditions, we reasoned that targeting GroEL/ES with small molecule inhibitors could be a viable antibacterial strategy. Extending from our initial screen, we report here the antibacterial activities of 22 GroEL/ES inhibitors against a panel of Gram-positive and Gram-negative bacteria, including E. coli, Bacillus subtilis, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter cloacae. GroEL/ES inhibitors were more effective at blocking the proliferation of Gram-positive bacteria, in particular S. aureus, where lead compounds exhibited antibiotic effects from the low-lM to mid-nM range. While several compounds inhibited the human HSP60/10 refolding cycle, some were able to selectively target the bacterial GroEL/ES system. Despite inhibiting HSP60/10, many compounds exhibited low to no cytotoxicity against human liver and kidney cell lines. Two lead candidates emerged from the panel, compounds 8 and 18, that exhibit >50-fold selectivity for inhibiting S. aureus growth compared to liver or kidney cell cytotoxicity. Compounds 8 and 18 inhibited drug-sensitive and methicillin-resistant S. aureus strains with potencies comparable to vancomycin, daptomycin, and streptomycin, and are promising candidates to explore for validating the GroEL/ES chaperonin system as a viable antibiotic target.

Gli stili APA, Harvard, Vancouver, ISO e altri

8

CULLIA, GREGORIO. "ENZYME INHIBITORS AS POTENTIAL ANTIPARASITIC AGENTS". Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/481792.

Testo completo

Abstract (sommario):

Abstract of the PhD thesis ENZYME INHIBITORS AS POTENTIAL ANTIPARASITIC AGENTS PhD course in Chemistry, XXIX cycle, University of Milan PhD student: Gregorio Cullia (R10447) Tutor: Prof. Paola Conti Co-tutor: Dr. Lucia Tamborini Protozoan parasitic diseases, such as Malaria and Human African Trypanosomiasis (HAT), have a tremendous health, social and economic impact on people living in tropical and subtropical regions of the world. While around 3.8 billion people are at risk of infection, [1] available treatments are unsatisfactory, mainly due to constantly increasing drug resistance. Hence, there is an urgent need of developing new chemotherapeutic agents acting on new molecular targets, such as essential parasitic enzymes. One selected target is the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) of P. falciparum, a key glycolytic enzyme with many other important functions. In this thesis, I describe the development of inhibitors that act alkylating, in a selective way, the catalytic cysteine, inspired by (S,S)-3-bromoacivicin [(S,S)-1]. [2]Some of the inhibitors, in particular (S,S)-9 and (S,S)-59, showed sub-micromolar EC50 toward P. falciparum cultures and a considerably low cytotoxicity toward human cell lines (≥ 20 mM). In the second project, the interesting 3-bromoisoxazoline warhead was coupled to known peptidic recognition moieties generating new inhibitors of rhodesain(TbCatL), an essential protease involved in virulence and defence processes of the parasite. [3] Some low micromolar inhibitors were identified, among which the diastereoisomeric mixture (S,S,S)-138/(S,R,R)-139 showed also an interesting antiparasitic activity. The third enzyme that was exploited as target is the N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase (TbFolD), a crucial enzyme involved in the folate pathway. I started synthesizing LY374571 [(S)-149], a known human FolD inhibitor, [4] with the aim of using it as a lead compound: interestingly, following the published synthesis protocol I unambiguously obtained compound (S)-156, with a structure different from the one reported in the literature. I performed a structure-activity relationships study replacing the glutamate tail with other α-, β- and γ-amino acids [compounds (S)-175-181]. Moreover, the first X-ray structure of TbFolD in presence of (S)-156 and NADP+,was obtained. [5] The last part of this PhD thesis regards the development of new potential agents for the treatment of C. trachomatis infections. This bacterium is the agent trachoma (a neglected tropical disease), an eye infection that causes the impairment of the sight of 1.9 million people, and of one of the most prevalent sexually transmitted infection. [6] In the past, the inhibitory activity of CI-976 (182) of inhibiting human lysophosphatidicacid:acyl-CoA acyl transferase(hLPAAT) was correlated to a delay in the slow recycling pathway of transferrin, that hampered the growth of the bacterium. [7] I performed an exhaustive structure-activity relationships study focusing on the different structural features of 182 (such as the α- and the N- substitutions and the properties of the aromatic ring). Among the synthesized compounds, 185 showed anti-chlamydial activity comparable to 182. This approach represents an innovative strategy to treat microbial infections, based on the inhibition of a trafficking pathway that is disposable for the human host. References [1] a. [Online]. Available: http://www.who.int/mediacentre/factsheets/fs094/en/;b. [Online]. Available: http://www.who.int/mediacentre/factsheets/fs259/en/. [2] S. Bruno, A. Pinto, G. Paredi, L. Tamborini, C. De Micheli, V. La Pietra, L. Marinelli, E. Novellino, P. Conti and A. Mozzarelli, “Discovery of covalent inhibitors of glyceraldehyde-3-phosphate dehydrogenase, a target for the treatment of malaria,” J. Med. Chem., vol. 57, pp. 7465-7471, 2014. [3] a. R. Ettari, S. Previti, L. Tamborini, G. Cullia, S. Grasso and M. Zappalà, “The inhibition of cysteine proteases rhodesain and TbCatB: a valuable approach to treat human African trypanosomiasis,” Mini-Rev. Med. Chem., 2016; b. R. Ettari, A. Pinto, S. Previti, L. Tamborini, I. C. Angelo, V. La Pietra, L. Marinelli, E. Novellino, T. Schirmeister, M. Zappalà, S. Grasso, C. De Micheli and P. Conti, “Development of novel dipeptide-like rhodesain inhibitors containing the 3-bromoisoxazoline warhead in a constrained conformation,” Bioorg. Med. Chem., vol. 23, pp. 7053-7060, 2015. [4] A. Schmidt, H. Wu, R. E. MacKenzie, V. J. Chen, J. R. Bewly, J. E. Ray, J. E. Toth and M. Cygler, “Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase,” Biochemistry, vol. 39, pp. 6325-6335, 2000. [5] T. C. Eadsforth, A. Pinto, R. Luciani, L. Tamborini, G. Cullia, C. De Micheli, L. Marinelli, S. Cosconati, E. Novellino, L. Lo Presti, A. Cordeiro da Silva, P. Conti, W. N. Hunter and M. P. Costi, “Characterization of 2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl ureido based inhibitors of TrypanosomabruceiFolD and testing for antiparasitic activity,” J. Med. Chem., vol. 58, no. 20, pp. 7938-7948, 2015. [6] World Health Organization, “WHO guidelines for the treatment of Chlamydia trachomatis,” 2016. [Online]. Available: http://www.who.int/reproductivehealth/publications/rtis/chlamydia-treatment-guidelines/en/. [7] a. K. Chambers, B. Judson and W. J. Brown, “A unique lysophospholipidacyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways,” J. Cell Sci., vol. 118, pp. 3061-3071, 2005; b. S. P. Ouellette and R. A. Carabeo, “A functional slow recycling pathway of transferrin is required for growth of Chlamydia,” Front. Microbiol.,vol. 1, 2010.

Gli stili APA, Harvard, Vancouver, ISO e altri

9

chaudhary, Arpana S. "Inhibitors of SecA as Potential Antimicrobial Agents". Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/chemistry_diss/77.

Testo completo

Abstract (sommario):

Protein translocation is essential for bacterial survival and the most important translocation mechanism in bacteria is the secretion (Sec) pathway. Thus targeting Sec pathway is a promising strategy for developing novel antibacterial therapeutics. We report the design, syntheses, mechanistic studies and structure-activity relationship studies using HQSAR and 3-D QSAR Topomer CoMFA analyses of 4-oxo-5-cyano thiouracil derivatives. In summary, introduction of polar group such as –N3 and linker groups such as –CH2-O- enhanced the potency as well as logP and logS several fold. We also report the discovery, optimization and structure-activity relationship study of 1,2,4-triazole containing pyrimidines as novel, highly potent antimicrobial agents. A number of inhibitors have been found to inhibit microbial growth at high nanomolar concentrations.

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Marr, Sharon Ann. "The synthesis of potential serine protease inhibitors". Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310261.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Libri sul tema "POTENTIAL INHIBITORS"

1

Casey, Lorraine A. The synthesis of potential enzyme inhibitors. Huddersfield: The Polytechnic, 1991.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Johnson, N. B. Modified peptides as potential enzyme inhibitors. Manchester: UMIST, 1994.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Noort, Daniël. Design, synthesis, and evaluation of potential inhibitors of UDP-glucuronosyltransferase. [The Netherlands: s.n.], 1992.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

International Symposium on Proteases: Potential Role in Health and Disease (2nd 1987 Rothenburg ob der Tauber, Germany). Proteases II: Potential role in health and disease. New York: Plenum Press, 1988.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

1930-, Smith H. J., e Simons Claire, a cura di. Proteinase and peptidase inhibition: Recent potential targets for drug development. London: Taylor & Francis, 2002.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Wiggins, Karen. Synthesis of potential phospholipase A2 inhibitors based on manoalide. Norwich: University of East Anglia, 1989.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Yap, Chee Hoong. Potential inhibitors of dihydrofolate reductase: Synthesis and NMR spectroscopy. Birmingham: University of Aston. Department of Molecular Sciences (Chemistry), 1985.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

8

1943-, Greenwald Robert A., Golub Lorne M e New York Academy of Sciences., a cura di. Inhibition of matrix metalloproteinases: Therapeutic potential. New York, N.Y: New York Academy of Sciences, 1994.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Quibell, Martin. The synthesis of azaglutamine containing peptides as potential inhibitors of the picornavirus 3C proteinase. Birmingham: University of Birmingham, 1991.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Surfraz, Mohammad Bashir-Uddin. Design and synthesis of novel inhibitors of Inositol Monophosphatase: Potential drug candidates in the treatment of Bipolar Disorder. Birmingham: University of Birmingham, 2003.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Capitoli di libri sul tema "POTENTIAL INHIBITORS"

1

Kumar, S., e S. M. Blake. "Pharmacological Potential of p38 MAPK Inhibitors". In Inhibitors of Protein Kinases and Protein Phosphates, 65–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-26670-4_4.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Rahman, Masmudur M., Alexandra R. Lucas e Grant McFadden. "Viral TNF Inhibitors as Potential Therapeutics". In Pathogen-Derived Immunomodulatory Molecules, 64–77. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-1601-3_5.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Gibbs, J. B., N. J. Anthony, I. Bell, C. A. Buser, J. P. Davide, S. J. deSolms, C. Dinsmore et al. "Farnesyltransferase Inhibitors as Potential Anticancer Agents". In Anticancer Agents, 190–98. Washington, DC: American Chemical Society, 2001. http://dx.doi.org/10.1021/bk-2001-0796.ch011.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Voss, Regis D. "Potential for Use of Urease Inhibitors". In Nitrogen in Crop Production, 571–77. Madison, WI, USA: American Society of Agronomy, Crop Science Society of America, Soil Science Society of America, 2015. http://dx.doi.org/10.2134/1990.nitrogenincropproduction.c38.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Mohan, C. Gopi, Ashish Pandey e Jignesh Mungalpara. "Therapeutic Potential of N-Type Voltage-Gated Ca2+ Channel". In Ion Channels and Their Inhibitors, 289–308. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-19922-6_10.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Mir, Manzoor Ahmad, e Tabish Javeed. "Novel CDK Inhibitors in Breast Cancer". In Therapeutic potential of Cell Cycle Kinases in Breast Cancer, 253–67. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-8911-7_12.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Yasar, S., G. Winger, B. Nickel, G. Schulze e S. R. Goldberg. "Preclinical Evaluation of l-Deprenyl: Lack of Amphetamine-Like Abuse Potential". In Inhibitors of Monoamine Oxidase B, 215–33. Basel: Birkhäuser Basel, 1993. http://dx.doi.org/10.1007/978-3-0348-6348-3_11.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Steinmetzer, Torsten, e Kornelia Hardes. "The Antiviral Potential of Host Protease Inhibitors". In Activation of Viruses by Host Proteases, 279–325. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-75474-1_11.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Kennedy, Ann R. "Potential Mechanisms of Antitumorigenesis by Protease Inhibitors". In Antimutagenesis and Anticarcinogenesis Mechanisms III, 301–7. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-2984-2_28.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Gupta, Annika Durve, e Sonali Zankar Patil. "Natural Medicinal Products as Potential Enzyme Inhibitors". In Enzyme Inactivation in Food Processing, 269–310. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003331797-13.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Atti di convegni sul tema "POTENTIAL INHIBITORS"

1

Kralevska, Angela, Marija Velichkovska, Viktor Cicimov, Tome Eftimov e Monika Simjanoska. "Finding Potential Inhibitors of COVID-19". In 12th International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and Technology Publications, 2021. http://dx.doi.org/10.5220/0010246900002865.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Kralevska, Angela, Marija Velichkovska, Viktor Cicimov, Tome Eftimov e Monika Simjanoska. "Finding Potential Inhibitors of COVID-19". In 12th International Conference on Bioinformatics Models, Methods and Algorithms. SCITEPRESS - Science and Technology Publications, 2021. http://dx.doi.org/10.5220/0010246901100117.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Sanni, Omotayo, Jianwei Ren e Tien-Chien Jen. "Exploring the Potential Role of Prunus Domestica in Corrosion Inhibition of AA6063-T5 Aluminium Alloy in Sodium Chloride Media". In ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-94911.

Testo completo

Abstract (sommario):

Abstract Aluminium is a material of choice in the industry for numerous applications due to its excellent properties. Unfortunately, the films formed are amphoteric and break when exposed to alkali and strong acid, making aluminium corrode. Diverse techniques have been used in mitigating aluminum against corrosion; product fluid blending, upgrading materials, chemical inhibition, and process control. Among these techniques, the use of inhibitors is considered one of the cheapest and most convenient means to fight corrosion, especially in chloride environments. Several organic and inorganic inhibitors for corrosion protection processes have been utilized in the industry, unfortunately, most corrosion inhibitors used in the industry are toxic and expensive, research has recently moved in the direction of nontoxic and low-cost inhibitors. Therefore, in the present work, the corrosion inhibition of AA6063-T5 aluminium alloy in sodium chloride (3.5% wt) solution by Prunus Domestica extract was studied. Electrochemical impedance spectroscopy, potentiodynamic polarization, and gravimetric techniques were utilized in this study. Scanning electron microscopy and energy dispersive X-ray techniques were employed to describe the surface morphology and elemental analysis, respectively. The results demonstrated that the presence of Prunus Domestica inhibits the corrosion of AA6063-T5 aluminium alloy with 99.01 % efficiency. The high corrosion resistance and low values of corrosion current, obtained from the electrochemical impedance spectroscopy, potentiodynamic polarization, and gravimetric experiments, affirmed the adequacy of Prunus Domestica as an excellent corrosion inhibitor for AA6063-T5 aluminium alloy.

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Luciano, V., J. Heering, E. Proschak e R. Marschalek. "Screening assay to identify potential Taspase1 inhibitors". In 32. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1687132.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Rocha, Sílvia, Álvaro Tomé, Ana Teresa Rufino, Marisa Freitas, Félix Carvalho, Artur Silva e Eduarda Fernandes. "Chalcones as Potential Inhibitors of Pancreatic Lipase". In International Electronic Conference on Medicinal Chemistry. Basel Switzerland: MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13413.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Almeida, Hélida Maravilha Dantas e. Sousa, Igor de Sousa Oliveira e Sávio Benvindo Ferreira. "Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors". In ECCM 2021. Basel Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/eccm-10853.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Donaldson, V. H., e M. D. B. H. Mitchell. "INTERACTIONS OF DYSFUNCTIONAL Cl-INHIBITORS FROM PATIENTS WITH TYPE II HEREDITARY ANGIONEUROTIC EDEMA (HANE) WITH ACTIVATED HAGEMAN FACTOR (FACTOR XIIa)." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643302.

Testo completo

Abstract (sommario):

Type II HANE is characterized by a deficiency of Cl-inhibitor (Cl-INH) activity in serum which is associated with a dysfunctional inhibitor protein having a normal or increased quantity o|_the antigenic properties of normal serum Cl-inhibitor. Dysfunctional Cl-INH proteins were purified from members_of eight different kindred with Type II HANE and compared to normal Cl-inhibitor with respect to their inhibitory activity directed against the amidolytic and clot-promoting properties of purified activated Hageman factor. All but one dysfunctional Cl-inhibitor blocked the amidolytic activity of ellagic acid-activated Hageman factor; all eight blocked the clot-promoting activity of Hageman factor activated in solutions of sulfatides and BSA. The inhibition _of amidolytic activity was equal to or greater than that of normal Cl-INH (Donaldson, et al., 3. Clin. Invest. 75:124,1985). The impairment of the specific Hageman factor coagulant activity of activated Hageman factor by six^f the eight dysfunctional inhibitors was less than that of the normal Cl-inhibitor, although readily measured. Dysfunctional Cl-inhibitor proteins were also heterogeneous with respect to their formation of stable complexes and their susceptibility to cleavage by Hageman factor activated with BSA-sulfatides when analyzed in SDS-gel electrophoresis. Although these observatons cannot be directly applied to in vivo pathophysiologic changes in plasma, dysfunctional Cl-inhibitors do have the potential of regulating activated Hageman factor.

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Sidorova, A. P., e A. V. Bakunovich. "ANTIRETROVIRAL DRUGS AS POTENTIAL INHIBITORS OF SARS-COV-2 Mpro". In SAKHAROV READINGS 2022: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute of Belarusian State University, 2022. http://dx.doi.org/10.46646/sakh-2022-2-31-34.

Testo completo

Abstract (sommario):

Ritonavir, nelfinavir and lopinavir are a group of protease inhibitors. These inhibitors are widely used in combination with other protease inhibitors in the therapy and prevention of human immunodeficiency virus. Also, the combination of these inhibitors seems to be an effective therapeutic agent that can affect the main protease of Mpro coronavirus and, thus, provide long-term suppression of viral load in the disease of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2).

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Yao, Xuanzhu, Xin Wang, Saebom Ko, Cianna Leschied, Yu Yi Shen, Daniel Pimentel, Chanaka Navarathna et al. "Fate and Transport of Sulfonated Polymeric Inhibitors in the Reservoir: Studied by Column Experiments With Calcite Media". In SPE International Conference on Oilfield Chemistry. SPE, 2023. http://dx.doi.org/10.2118/213787-ms.

Testo completo

Abstract (sommario):

Abstract Sulfonated polymers are frequently used in the oil and gas industry to prevent inorganic scale damage, but studying their fate and transport in reservoirs has been difficult due to the challenges in analyzing them at effective concentrations. Recycling inhibitors in reservoirs necessitates inhibitors that do not adhere strongly to mineral surfaces, making polymeric inhibitors a promising option. This research aims to examine the sorption and transport of sulfonated polymeric inhibitors in calcite-packed columns using the Brine Chemistry Inhibitor (BCIn) technique, with the goal of recycling the inhibitors, specifically in the Permian basin. The BCIn method was used in this study to determine concentrations of sulfonated inhibitors, which had been shown to be reliable for measuring polymeric inhibitors at near ppm levels. The study began with conducting batch experiments on barite and calcite salts to gain initial insights into the adsorption properties of inhibitors. Next, flow-through experiments were performed where sulfonated inhibitors were injected into a column packed with calcite, followed by a flow-back test. Different sulfonated polymeric inhibitors were tested under various temperatures in the lab’s synthetic brine matrices. The concentrations of sulfonates versus injected time were plotted to assess the retention of inhibitors on rock surfaces. A commonly used phosphonate scale inhibitor (DTPMP) was included for comparison of adsorption characteristics. The experimental findings suggest that sulfonated polymeric inhibitors exhibit limited adsorption capacity but strong binding between inhibitor molecules and mineral surfaces. An inhibitor treatment scenario is proposed, where the first injection is used to saturate the surfaces of rocks, and subsequently, produced water containing low-concentration inhibitors can be recycled. The research expands our understanding of sulfonated polymeric scale inhibitors’ fate and transport in reservoirs, overcoming the challenge of analyzing polymeric inhibitors at low concentrations. The results provide evidence supporting the potential of applying polymeric inhibitors via injection wells for safeguarding production.

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Šimák, Ondřej, Petr Pachl, Jiří Brynda e Ivan Rosenberg. "Synthesis of new potential inhibitors of 5'-nucleotidases". In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112462.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Rapporti di organizzazioni sul tema "POTENTIAL INHIBITORS"

1

Roberge, Michel. Study of mTOR Signaling Inhibitors as Potential Treatment for TSC. Fort Belvoir, VA: Defense Technical Information Center, luglio 2013. http://dx.doi.org/10.21236/ada601809.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Obrien, Ivette Z. Biotransformation Potential and Uncoupling Behavior of Common Benzotriazole-Based Corrosion Inhibitors. Fort Belvoir, VA: Defense Technical Information Center, gennaio 2002. http://dx.doi.org/10.21236/ada414450.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Adkins, James, Thomas Eaton e Airan Perez. Potential Aminoquinone Inhibitors of CE and BMI/Carbon Fiber/Aluminum Composite Galvanic Degradation. Fort Belvoir, VA: Defense Technical Information Center, gennaio 1994. http://dx.doi.org/10.21236/ada390062.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Sisler, Edward C., Raphael Goren e Akiva Apelbaum. Controlling Ethylene Responses in Horticultural Crops at the Receptor Level. United States Department of Agriculture, ottobre 2001. http://dx.doi.org/10.32747/2001.7580668.bard.

Testo completo

Abstract (sommario):

Ethylene is a plant hormone that controls many plant responses, such as growth, senescence, ripening, abscission and seed germination. Recently, 1-methy- cyclopropene (1-MCP), was shown to bind to ethylene receptor for a certain period of time and prevent ethylene action. The objectives of this research were to synthesize analogues of 1-MCP and test their potency to block the ethylene receptor and inhibit ethylene action. During the course of this project, procedures for synthesis and shipment of the cyclopropene compounds were developed as well assay procedures for each compound were worked out. Thirteen new compounds were synthesized. All of them are structural analogues of 1-MCP, with substitution in the 1-position and a side chain containing 2 to 10 carbons. After preliminary studies, nine promising compounds were selected for in-depth study. The potency of the compounds to inhibit ethylene action was tested on a wide scope of systems like: climacteric fruits (banana, avocado and tomato), the triple response (etiolated peas), and leaf abscission (citrus). As the putative inhibitors are suspected to compete for the site of binding and a competitive type of inhibition could be considered, a high concentration of ethylene (300 m1.L-1) was used to induce ripening and other physiological processes. The tests were conducted under extreme conditions which hasten ripening like treatment and storage at 22 to 25oC. There were fluctuations in the responses as related to the concentrations of the inhibitors. Some required much higher concentration to exert the same effect, while some, when applied at the same concentration, blocked the receptor for a longer period of time than the others. Some fruits and other plant organs responded differently to the same inhibitor, indicating differences in characteristics and availability of the ethylene receptors in the various tissues. The potency of the putative inhibitors was found to be greatly affected by their molecular structural and size. In addition, it was found that treatment with the inhibitor should be given before the onset of ethylene action In the case of fruit, treatment should be carried out before the pre-climacteric stage. Simultaneous treatment with ethylene and the inhibitors reduced the inhibitors' effect. The relationship between ethylene and the inhibitors is of a non-competitive nature. All the fruits treated with the putative inhibitors resumed normal ripening after recovery from the inhibition. This fact is of great importance when considering the inhibitors for practical use. The advantage of using inhibitors of ethylene action over inhibitors of ethylene production lies in the ability of the inhibitors of ethylene action to protect the tissue against both endogenous and exogenous ethylene, thus providing better overall protection. Our findings indicate that 1-MCP and its structural analogues are potent inhibitors of ethylene action capable of providing good protection against endogenous and exogenous ethylene. The fact that the compounds are in a gas phase and are non-phytotoxic, odorless and effective at minute concentrations, renders them promising candidates for commercial use. However, the development of water-soluble inhibitors will expand the potential use of the inhibitors in agriculture.

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Beavers, Gui e Sridhar. PR-186-073508-R01 Environmental and Stress Factors that Produce SCC in Existing Ethanol Facilities. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), febbraio 2011. http://dx.doi.org/10.55274/r0010441.

Testo completo

Abstract (sommario):

The potential exists for stress corrosion cracking (SCC) of carbon steel pipelines transporting fuel grade ethanol (FGE) and FGE- gasoline blends. The objective of SCC 4-3 Phase 2 was determine if inhibitors are effective in preventing SCC growth under more realistic field conditions than those found in the slow strain rate (SSR) tests performed previously. The results of the research demonstrated that: 1. Un-notched SSR test results generally correlated well with the results of the crack growth tests using precracked CT specimens, although the latter test technique was somewhat more aggressive. 2. The notched SSR test technique was so aggressive that it was not useful for screening SCC inhibitors. 3. E-50, prepared with a simulated FGE was consistently more potent as a cracking agent than SFGE. 4. Some commercial inhibitors were effective in inhibiting ethanol SCC under many of the test conditions. 5. The commercial inhibitors, in general, were less effective in E-50 than in SFGE. 6. Ammonium hydroxide, at a relatively low concentration, was by far the most effective inhibitor evaluated. 7. For one commercial inhibitor, a higher concentration was needed to inhibit SCC in one lot of corn based FGE than in SFGE. 8. Water inhibited, but did not completely arrest, SCC in the crack growth tests in SFGE. 9. Sustained crack growth was observed in SFGE in which no chloride was added. 10. Evidence of loss of inhibition, at low concentrations, was observed in an inhibition scheme for batching of FGE with gasoline in which a high initial dose, followed by a low maintenance dose was used.

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Kockel, Lutz. Isolation and Analysis of Human Kekkon-Like Molecules, a Family of Potential Inhibitors of ErbB Receptor Tyrosine Kinases. Fort Belvoir, VA: Defense Technical Information Center, aprile 2005. http://dx.doi.org/10.21236/ada443751.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Shukla, Pavan, Xihua He, Osvaldo Pensado e Andrew Nordquist. PR-015-153602-R01 Vapor Corrosion Inhibitors Effectiveness for Tank Bottom Plate Corrosion Control. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), maggio 2018. http://dx.doi.org/10.55274/r0011485.

Testo completo

Abstract (sommario):

Soil side corrosion of the above ground storage tanks bottoms is a major challenge for the midstream operators owning tanks farms. In North America subcontinent, a large fraction of tanks are installed with an active cathodic protection (CP) system to protect the tank bottom from corrosion. However, CP systems could fail, and sometime even with the CP system, corrosion can occur. In addition, several tanks without CP system could experience elevated corrosion including pitting corrosion. Vapor corrosion inhibitors (VCIs) are being promoted as alternative corrosion control measures in addition to the CP. This study was conducted to determine whether the VCIs are effective in mitigating corrosion to a level comparable to a working CP for tank bottoms, what is the best way to monitor efficacy of VCIs, and whether the VCIs compatible with CP or not. Extensive amount of laboratory scale and limited field testing was conducted. Both laboratory and field data were rigorously analyzed. It was found that the VCIs are effective in mitigating corrosion when vendor specific recommended dosages are used, and the electrical-resistance based corrosion rate monitoring technique does show the effect of VCIs. Regarding VCI and CP compatibility, VCIs indirectly affect the CP as exposure of tank bottom steel to VCIs change its native potential which in turn changes the CP current demand. Overall, VCIs were found to be a viable alternative corrosion control measure.

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Vera, Jose, e Ken Evans. PR186-203600-Z01 Impact of Drag Reducing Agents on Corrosion Management. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), ottobre 2021. http://dx.doi.org/10.55274/r0012177.

Testo completo

Abstract (sommario):

The purpose of this research was to understand the potential impact of drag reducing agents (DRA) on internal corrosion of liquid hydrocarbon pipelines. The first task of this project included a comprehensive review of literature and knowledge, both in public domain and from industry experience, on the effect of DRA on water and solid transport in liquid hydrocarbons, and possible interactions with other performance chemicals typically used in the oil and gas industry. This was the basis for defining the final bench test methodology and test matrix to be performed in the second task. A novel bench-top apparatus was designed based on a vertical Couette cell approach, and a test methodology was successfully implemented to evaluate the potential effect(s) of DRA on water accumulation and localized corrosion at the oil/water interface. A test matrix was conducted with two DRAs (a water based and an oil based) and two corrosion inhibitors (a water soluble and an oil soluble) at a given test condition (3.5% NaCl saturated with 97%CO2/3%O2, pH ~6 at 80 oF). There is a related webinar.

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Koniaris, Leonidas G. MIC-1, A Potential Inhibitor of Breast Tumor Progression. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2005. http://dx.doi.org/10.21236/ada446419.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Koniaris, Leonidas G. MIC-1, A Potential Inhibitor of Breast Tumor Progression. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2004. http://dx.doi.org/10.21236/ada435049.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Offriamo sconti su tutti i piani premium per gli autori le cui opere sono incluse in raccolte letterarie tematiche. Contattaci per ottenere un codice promozionale unico!