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Letteratura scientifica selezionata sul tema "Proteoglycans Physiological effect"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 31 gennaio 2023

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Articoli di riviste sul tema "Proteoglycans Physiological effect"

1

Hamati, H. F., E. L. Britton, and D. J. Carey. "Inhibition of proteoglycan synthesis alters extracellular matrix deposition, proliferation, and cytoskeletal organization of rat aortic smooth muscle cells in culture." Journal of Cell Biology 108, no. 6 (June 1, 1989): 2495–505. http://dx.doi.org/10.1083/jcb.108.6.2495.

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Arterial proteoglycans have been implicated in several important physiological processes ranging from lipid metabolism to regulation of smooth muscle cell growth. Vascular smooth muscle (VSM) cells are the major producers of proteoglycans in the medial layer of blood vessels. To study functional consequences of alterations in VSM proteoglycan metabolism we used 4-methylumbelliferyl-beta-D-xyloside to inhibit proteoglycan synthesis in primary and early passage cultures of rat aortic smooth muscle cells. Biochemical analysis of cultures labeled with 35SO4 showed the drug inhibited synthesis of d

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2

Sah, R. L. Y., A. J. Grodzinsky, A. H. K. Plaas, and J. D. Sandy. "Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants." Biochemical Journal 267, no. 3 (May 1, 1990): 803–8. http://dx.doi.org/10.1042/bj2670803.

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The effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in calf cartilage explants were examined. Pulse-chase experiments showed that conversion of low-affinity monomers to the high-affinity form (that is, to a form capable of forming aggregates with 1.6% hyaluronate on Sephacryl S-1000) occurred with a t1/2 of about 5.7 h in free-swelling discs at pH 7.45. Static compression during chase (in pH 7.45 medium) slowed the conversion, as did incubation in acidic medium (without compression). Both effects were dose-dependent. For example, the t1/2

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3

Kolb, Martin, Peter J. Margetts, Patricia J. Sime та Jack Gauldie. "Proteoglycans decorin and biglycan differentially modulate TGF-β-mediated fibrotic responses in the lung". American Journal of Physiology-Lung Cellular and Molecular Physiology 280, № 6 (1 червня 2001): L1327—L1334. http://dx.doi.org/10.1152/ajplung.2001.280.6.l1327.

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Transforming growth factor (TGF)-β is a key cytokine in the pathogenesis of pulmonary fibrosis, and pharmacological interference with TGF-β can ameliorate the fibrotic tissue response. The small proteoglycans decorin and biglycan are able to bind and inhibit TGF-β activity in vitro. Although decorin has anti-TGF-β properties in vivo, little is known about the physiological role of biglycan in vivo. Adenoviral gene transfer was used to overexpress active TGF-β, decorin, and biglycan in cell culture and in murine lungs. Both proteoglycans were able to interfere with TGF-β bioactivity in vitro in

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4

Schröer, Katrin, Montaha Alshawabkeh, Sebastian Schellhorn, Katrin Bronder, Wenli Zhang, and Anja Ehrhardt. "Influence of Heparan Sulfate Proteoglycans and Factor X on species D Human Adenovirus Uptake and Transduction." Viruses 15, no. 1 (December 24, 2022): 55. http://dx.doi.org/10.3390/v15010055.

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More than 100 human adenovirus (Ad) types were identified, of which species D comprises the largest group. Heparan sulfate proteoglycans (HSPGs) were shown to function as cell surface receptors for cell binding and uptake of some Ads, but a systematic analysis of species D Ads is lacking. Previous research focused on Ad5 and blood coagulation factor X (FX) complexes, which revealed that Ad5 can transduce cells with low expression levels of its main coxsackievirus-adenovirus receptor in the presence of high HSPG expression levels in a FX dependent manner. Based on our reporter gene-tagged Ad-li

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5

Váncza, Lórand, Péter Tátrai, Andrea Reszegi, Kornélia Baghy, and Ilona Kovalszky. "SPOCK1 with unexpected function. The start of a new career." American Journal of Physiology-Cell Physiology 322, no. 4 (April 1, 2022): C688—C693. http://dx.doi.org/10.1152/ajpcell.00033.2022.

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SPOCK1, 2, and 3 are considered matricellular proteoglycans without a structural role. Their functions are only partly elucidated. SPOCK1 was detected in the brain as a member of the neural synapses, then in the neuromuscular junctions. It plays a role in the regulation of the blood-brain barrier. Its best-characterized activity was its oncogenic potential discovered in 2012. Its deleterious effect on tumor progression was detected on 36 different types of tumors by the end of 2020. However, its mode of action is still not completely understood. Furthermore, even less was discovered about its

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6

Al-Jamal, Rehab, and Mara S. Ludwig. "Changes in proteoglycans and lung tissue mechanics during excessive mechanical ventilation in rats." American Journal of Physiology-Lung Cellular and Molecular Physiology 281, no. 5 (November 1, 2001): L1078—L1087. http://dx.doi.org/10.1152/ajplung.2001.281.5.l1078.

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Excessive mechanical ventilation results in changes in lung tissue mechanics. We hypothesized that changes in tissue properties might be related to changes in the extracellular matrix component proteoglycans (PGs). The effect of different ventilation regimens on lung tissue mechanics and PGs was examined in an in vivo rat model. Animals were anesthetized, tracheostomized, and ventilated at a tidal volume of 8 (Vt 8), 20, or 30 (Vt 30) ml/kg, positive end-expiratory pressure of 0 (PEEP0) or 1.5 (PEEP1.5) cmH2O, and frequency of 1.5 Hz for 2 h. The constant-phase model was used to derive airway

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7

Valentim da Silva, Rodrigo Marcel, Priscila Arend Barichello, Melyssa Lima Medeiros, Waléria Cristina Miranda de Mendonça, Jung Siung Camel Dantas, Oscar Ariel Ronzio, Patricia Meyer Froes, and Hassan Galadari. "Effect of Capacitive Radiofrequency on the Fibrosis of Patients with Cellulite." Dermatology Research and Practice 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/715829.

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Background. Cellulite is a type of lipodystrophy that develops primarily from an alteration in blood circulation or of the lymphatic system that causes structural changes in subcutaneous adipose tissue, collagen, and adjacent proteoglycans. The radiofrequency devices used for cutaneous applications have shown different physiological treatment effects, but there is controversy about the suitable parameters for this type of treatment.Objectives. The aim of this study was to evaluate the effects of low-temperature radiofrequency to confirm the thinning of the collagen tissue and interlobular sept

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Gilbert, Sophie Jane, Cleo Selina Bonnet, and Emma Jane Blain. "Mechanical Cues: Bidirectional Reciprocity in the Extracellular Matrix Drives Mechano-Signalling in Articular Cartilage." International Journal of Molecular Sciences 22, no. 24 (December 18, 2021): 13595. http://dx.doi.org/10.3390/ijms222413595.

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The composition and organisation of the extracellular matrix (ECM), particularly the pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the presence of proteoglycans such as aggrecan, entrapped within a type II collagen fibrillar network, confers mechanical resilience underweight-bearing. Furthermore, components of the PCM including type VI collagen, perlecan, small leucine-rich proteoglycans—decorin and biglycan—and fibronectin facilitate the transduction of both biomechanical and biochemical signals to the residing chondrocytes, thereby regulati

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9

Alter, S. C., D. D. Metcalfe, T. R. Bradford, and L. B. Schwartz. "Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides." Biochemical Journal 248, no. 3 (December 15, 1987): 821–27. http://dx.doi.org/10.1042/bj2480821.

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Tryptase was previously shown to undergo rapid inactivation under physiological conditions unless stabilized by the presence of heparin. The current study shows that increasing the concentration of free tryptase enhances the preservation of enzymic activity, consistent with dissociation of the tetramer, rather than autodegradation, as the mechanism of inactivation. Heparin glycosaminoglycan fragments of Mr greater than 5700 are necessary for complete stabilization of tryptase activity. This stabilizing effect depends upon negative charge density rather than carbohydrate composition. Thus, kera

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10

Lee, Young Hun, Jun Hyoung Park, Dong Huey Cheon, Taeyoung Kim, Yae Eun Park, Eok-Soo Oh, Ji Eun Lee, and Seung-Taek Lee. "Processing of syndecan-2 by matrix metalloproteinase-14 and effect of its cleavage on VEGF-induced tube formation of HUVECs." Biochemical Journal 474, no. 22 (November 1, 2017): 3719–32. http://dx.doi.org/10.1042/bcj20170340.

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Syndecans (SDCs) are transmembrane proteoglycans that are involved in cell adhesion and cell communication. Specifically, SDC2 plays a key role in tumorigenesis, metastasis, and angiogenesis. Previously, we found that rat SDC2 is shed by matrix metalloproteinase-7 (MMP-7) in colon cancer cells. Here, we analyzed the susceptibility of rat SDC2 to various MMPs. We found that the rat SDC2 ectodomain (ECD) fused to the C-terminal Fc region, which was expressed in mammalian cells, was cleaved more efficiently by MMP-14 than MMP-7. Likewise, when anchored on the surface of HeLa cells, rat SDC2 was c

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Più fonti

Tesi sul tema "Proteoglycans Physiological effect"

1

陳智恆 and Chi-hang Chan. "A study of the physiological roles of proteoglycans in the inflammatory bronchial environment of patients with bronchiectasis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B30408751.

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De, Angelis Daniel. "Syndecan-1 expression during postnatal tooth and oral mucosa development in 2 day to 6 week old rats." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09DM/09dmd284.pdf.

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Includes bibliographical references (leaves 68-76) Aims to observe changes in the expression of syndecan-1 in both the developing epithelium of the rat oral mucosa, and in epithelial cell rests of Malassez in the developing periodontium of normal rat molars, from late crown development through to early eruption.

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Chai, Lin. "Proteoglycans in the inner limiting membrane and their influence on axonal behavior in embryonic chicken retina." Thesis, 1993. http://hdl.handle.net/1957/36250.

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Shi, Lei. "On the Mechanical Experiments and Modeling of Human Cervix." Thesis, 2021. https://doi.org/10.7916/d8-eaga-g814.

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The mechanical function of the uterine cervix is critical for a healthy pregnancy. During pregnancy, the cervix undergoes a significant remodeling from a mechanical barrier into a compliant structure to allow for a successful delivery. A too early or too late cervical softening will lead to spontaneous preterm births (sPTB) or dystocia. PTB is a leading cause of neonatal death, affecting 15 million newly born babies each year around the world. According to CDC, the rate of PTB increases in recent years. Dystocia increases the risk to both mother and newborn babies, leading to neonatal asphyxia

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De, Angelis Daniel. "Syndecan-1 expression during postnatal tooth and oral mucosa development in 2 day to 6 week old rats." Thesis, 2000. http://hdl.handle.net/2440/110399.

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Aims to observe changes in the expression of syndecan-1 in both the developing epithelium of the rat oral mucosa, and in epithelial cell rests of Malassez in the developing periodontium of normal rat molars, from late crown development through to early eruption.<br>Thesis (M.D.S.) -- University of Adelaide, School of Dentistry, 2001

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Libri sul tema "Proteoglycans Physiological effect"

1

David, Evered, Whelan Julie, and Symposium on Functions of the Proteoglycans (1986 : Ciba Foundation), eds. Functions of the proteoglycans. Chichester: Wiley, 1986.

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The role of proteoglycans and glycosaminolglycans in aging. Basel: Karger, 1994.

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3

Chai, Lin. Proteoglycans in the inner limiting membrane and their influence on axonal behavior in embryonic chicken retina. 1993.

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Atti di convegni sul tema "Proteoglycans Physiological effect"

1

Seror, Jasmine, Nir Kampf, Alice Maroudas, and Jacob Klein. "Nanotribological Investigation of the Role of Proteoglycans in Biolubrication." In ASME 2008 9th Biennial Conference on Engineering Systems Design and Analysis. ASMEDC, 2008. http://dx.doi.org/10.1115/esda2008-59390.

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Articular joints in human body are uniquely efficient lubrication systems. While the cartilage surfaces slide past each other under physiological working conditions (pressure of tens of atmospheres and shear rates up to 106 – 107 Hz), the friction coefficient (μ) achieves extremely low values (down to 0.001) never successfully reached by mechanical prosthetic devices. Friction studies on polymer brushes attached to surfaces have recently demonstrated (17) their ability to reduce friction between the rubbing surfaces to extremely low values by means of the hydrated ions and the charges on the p

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2

Huyghe, J. M., C. J. M. Jongeneelen, F. Kraaijeveld, and Y. Schroeder. "3D Finite Strains in Bovine Annulus Fibrosus Tissue." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176508.

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Intervertebral disc tissue consists of a fluid-filled extra-cellular matrix, in which living cells are sparsely dispersed. The mechanical function is highly dependent on the composition of the extra-cellular matrix, which primary consists of collagen fibrils and negatively charged proteoglycans. Due to the fixed charges of the proteoglycans (PG’s), the cation concentration inside the tissue is higher than physiological. This excess of ion particles leads to an osmotic pressure difference, which causes swelling of the tissue [1]. Because the intervertebral disc is gripped between two vertebrae,

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3

Rahimi, Abdolrasol, and Hamed Hatami-Marbini. "Hydration Effects on Tensile Properties of the Corneal Stroma." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14788.

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The mechanical behavior of the cornea is mainly governed by the microstructure and composition of the stroma. The stroma is a highly ordered extracellular matrix and constitutes about 90% of the corneal thickness. From the mechanics point of view, the corneal stroma can be considered as a polyelectrolyte gel which is composed of collagen fibrils embedded in an aqueous matrix. The collagen fibrils compose about 70% of cornea’s dry mass and are arranged in a regular lattice structure [2]. Previous studies have shown that while the collagen fibrils are primarily located parallel to the surface, t

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Mochizuki, Shota, Shun Yanagida, and Hiromichi Fujie. "Effect of Enzymatic Degeneration on the Frictonal Property of Articular Cartilage." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14461.

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Articular cartilage is consisted of the chondrocyte, collagen fibers and proteoglycan, and interstitial fluid. Basalo et al reported that the coefficient of friction of bovine articular cartilage on a glass surface measured in unconfined compression fashion was increased by the degeneration of proteoglycan [1]. In their friction test, it was difficult to test a small cartilage sample having undulation while the loaded area in cartilage specimen was almost unchanged during friction. For the assessment of frictional properties of enzymatically degenerated cartilage in more physiological conditio

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Hussain, Mozammil, Raghu N. Natarajan, Gunnar B. J. Andersson, and Howard S. An. "Effect of a Degenerated C5-C6 Disc on the Biomechanics of Adjacent Levels: A Poroelastic Finite Element Investigation." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176621.

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Degenerative changes in the cervical spine due to aging are very common causes of neck pain in general population. Although many investigators have quantified the gross morphological changes in the disc with progressive degeneration, the biomechanical changes due to degenerative pathologies of the disc and its effect on the adjacent levels are not well understood. Despite many in vivo and in vitro techniques used to study such complex phenomena, the finite element (FE) method is still a powerful tool to investigate the internal mechanics and complex clinical situations under various physiologi

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Killian, Megan L., та Tammy L. Haut Donahue. "Effect of Pathological and Physiological Loads on Interleukin-1α Protein Production in Porcine Menisci". У ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192145.

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The meniscus performs several functions for the maintenance of knee joint health, such as load transmission and joint stability. Meniscal lesions have been suggested as a precursor to the onset of osteoarthritis (OA)[1]. Such lesions often lead to surgical removal of the torn portion of the meniscus, increasing cartilage to cartilage contact area. Partial meniscectomies have been shown using finite element analysis and histology to lead to altered and increased mechanical loading on the remaining meniscus and underlying articular cartilage[2,3]. Consequently, pathological compressive strains o

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Patel, Nisha S., and Alisa Morss Clyne. "A Computational Model of Fibroblast Growth Factor-2 Binding to Isolated and Intact Cell Surface Receptors: Effects of Fibroblast Growth Factor-2 Concentration, Flow and Delivery Mode." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80798.

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Fibroblast growth factor-2 (FGF2) plays an important role in both healthy vascular cell functions and pathogenesis in cancer, atherosclerosis and reduced perfusion in diabetes (1–4). FGF2 therapy and targeted drug delivery have great potential in the treatment of such diseases, but have had little clinical success. FGF2 binding kinetics to heparan sulfate proteoglycan (HSPG) and fibroblast growth factor receptors (FGFR) have been largely studied under static conditions (5), however FGF2 binding to endothelial cells occurs physiologically under fluid flow conditions. Understanding complex FGF2

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8

Kasra, Mehran, Vijay Goel, James Martin, Shea-Tien Wang, Woosung Choi, and Joseph Buckwalter. "Effects of Hydrostatic Loading Amplitude and Frequency on Rabbit Disc Nucleus Cells." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/bed-23146.

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Abstract Long-term occupational exposure to whole-body vibration increases the risk of disc degeneration and the consequent back pain [1]. The pathogenesis of vibration induced disorders is still not completely clear and there is no effective treatment. Although the potential effects of vibrational stress on extracellular matrix (ECM) assembly and degradation are particularly relevant to the clinical findings of the vibration induced disorders, the effects of vibrational loads on disc cells are largely unknown. It has been shown that hydrostatic pressure directly affects the synthesis of colla

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Sampat, Sonal R., Drew A. Robinson, George P. Ackerman, Matthew V. Dermksian, Gerard A. Ateshian, and Clark T. Hung. "Applied Osmotic Loading for Promoting Development of Engineered Cartilage." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80449.

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The avascular nature of cartilage and the harsh joint loading environment lead to a poor intrinsic healing capacity after injury, motivating the development of cell-based therapies for repair. Synovium-derived stem cells (SDSCs) have the potential for differentiating down a chondrogenic lineage and are thought to aid in articular cartilage repair after damage in vivo1. In the present study, we adopt a two-pronged strategy for growing clinically relevant cartilage grafts. Firstly, we compare the potential of SDSCs versus chondrocytes for engineering functional constructs. Secondly, we investiga

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Nguyen, Thao D., Reese E. Jones, and Brad L. Boyce. "Modeling the Finite Deformation Anisotropic Viscoelastic Behavior of the Cornea." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192916.

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This paper presents the development of a finite element model for the cornea as a first step towards a physiologically based model to study the role of cornea and sclera biomechanics in glaucoma. We developed a finite-deformation anisotropic constitutive model of the cornea that considers the effects of the fibrilar microstructure on the viscoelastic stress response. The model was base on the hypothesis that the dominant mechanism for the tensile viscoelastic behavior of the cornea is the viscoelastic stretching of the collagen lamellae. This approach yielded two main results. First, the visco

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