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Articoli di riviste sul tema "RANTES"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

Hoover, David M., Jeffrey Shaw, Zygmunt Gryczynski, Amanda E. I. Proudfoot, Tim Wells, and Jacek Lubkowski. "The crystal structure of met-rantes: comparison with native rantes and aop-rantes." Protein & Peptide Letters 7, no. 2 (2000): 73–82. http://dx.doi.org/10.2174/092986650702221206112548.

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Abstract: Met-RANTES is a modified version of the chemokine RANTES, which has an additional amino acid at the amino terminus. To compare Met-RANTES with the native protein as well as with another antagonist, AOP RANTES, we have solved the structure of Met-RANTES at 1.6 A by X-ray crystallography and investigated the dimerization of all three proteins by fluorescence anisotropy. The dimerization of AOP-RANTES shows an altered aggregation profile. The delineation of slight differences in binding sulfate anions by Met- and AOP RANTES might be linked to specific yet different interactions betwee

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2

McLean, Adam. "Regulation with RANTES." Lancet 343, no. 8891 (1994): 189–90. http://dx.doi.org/10.1016/s0140-6736(94)90985-7.

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Pattison, James M., Peter J. Nelson, and Alan M. Krensky. "The RANTES Chemokine." Clinical Immunotherapeutics 4, no. 1 (1995): 1–8. http://dx.doi.org/10.1007/bf03259067.

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Proudfoot, Amanda E. I., Raphaële Buser, Fredéric Borlat, et al. "Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors." Journal of Biological Chemistry 274, no. 45 (1999): 32478–85. http://dx.doi.org/10.1074/jbc.274.45.32478.

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Hayashi, Kunio, Shosaku Nomura, Atsuko Mugitani, et al. "Chemokine RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted) in Multiple Myeloma and MGUS (Monoclonal Gammopathy of Undetermined Significance)." Blood 110, no. 11 (2007): 4756. http://dx.doi.org/10.1182/blood.v110.11.4756.4756.

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Abstract Introduction: Bone disease in patients with myeloma is the devastating complication. RANTES (CCR chemokine, Regulated upon Activation,Normal T Cell Expressed and Secreted) is involved in the bone remodeling that is made by coupled functions of osteoclasts and osteoblasts. Osteoclasts represent the RANTES receptor CCR1 and product RANTES. Osteoblasts express CCR1,3,4,5, and also product RANTES. Osteoblasts chemotaxicaly move to osteoclasts to repair the absorbed bone lesions (Shozo Yano et al., Endocrinology Vol.145, No.5, 2324–2335). The bone pathophysiology of multiple myeloma is the

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6

Rutherford, Adam, and Jonathan Weitzman. "Split-personality RANTES mutation." Trends in Molecular Medicine 7, no. 1 (2001): 12. http://dx.doi.org/10.1016/s1471-4914(00)01893-1.

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Rodríguez-Frade, José M., Antonio J. Vila-Coro, Ana Martín, et al. "Similarities and Differences in RANTES- and (AOP)-RANTES–triggered Signals: Implications for Chemotaxis." Journal of Cell Biology 144, no. 4 (1999): 755–65. http://dx.doi.org/10.1083/jcb.144.4.755.

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Chemokines are a family of proinflammatory cytokines that attract and activate specific types of leukocytes. Chemokines mediate their effects via interaction with seven transmembrane G protein–coupled receptors (GPCR). Using CCR5-transfected HEK-293 cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)- RANTES, trigger immediate responses such as Ca2+ influx, receptor dimerization, tyrosine phosphorylation, and Gαi as well as JAK/STAT association to the receptor. In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by

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8

Mack, Matthias, Bruno Luckow, Peter J. Nelson, et al. "Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity." Journal of Experimental Medicine 187, no. 8 (1998): 1215–24. http://dx.doi.org/10.1084/jem.187.8.1215.

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CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH2-terminal modification of the CCR5 ligand regulated on activation, normal T cell expressed and secreted (RANTES), aminooxypentane-RANTES (AOP-RANTES), that showed potent inhibition of macrophage infection by HIV-1 under conditions where RANTES was barely effective. To investigate the mechanism of AOP-RANTES inhibition of HIV infectivity we examined the surface expression of CCR5 using a monoclonal anti-CCR5 antibody, MC-1. We demonstrate that AOP

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9

Mori, Naoki, Alan M. Krensky, Romas Geleziunas та ін. "Helicobacter pylori Induces RANTES through Activation of NF-κB". Infection and Immunity 71, № 7 (2003): 3748–56. http://dx.doi.org/10.1128/iai.71.7.3748-3756.2003.

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ABSTRACT Helicobacter pylori-infected gastric mucosa displays a conspicuous infiltration of mononuclear cells and neutrophils. RANTES (short for “regulated upon activation, normal T cell expressed and secreted”) is a chemoattractant cytokine (chemokine) important in the infiltration of T lymphocytes and monocytes. RANTES may therefore contribute to the cellular infiltrate in the H. pylori-infected gastric mucosa. The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated RANTES expression. We observed that gastric epithelial cells produced RANTES upon cocul

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FRANK, Stefan, Heiko KÄMPFER, Christian WETZLER, Birgit STALLMEYER, and Josef PFEILSCHIFTER. "Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression." Biochemical Journal 347, no. 1 (2000): 265–73. http://dx.doi.org/10.1042/bj3470265.

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We investigated the role of NO on expressional regulation of the chemotactic cytokine RANTES (regulated upon activation, normal T-cell expressed and secreted) during tissue regeneration using an excisional wound-healing model in mice. Wound repair was characterized by a large and sustained induction of RANTES expression, and inhibition of inducible nitric oxide synthase (iNOS) during repair only slightly decreased RANTES expression levels. Immunohistochemical analysis revealed keratinocytes of the wound margins and the hyperproliferative epithelium to be the main RANTES-expressing cell type wi

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Gordon, Cynthia J., Mark A. Muesing, Amanda E. I. Proudfoot, Christine A. Power, John P. Moore, and Alexandra Trkola. "Enhancement of Human Immunodeficiency Virus Type 1 Infection by the CC-Chemokine RANTES Is Independent of the Mechanism of Virus-Cell Fusion." Journal of Virology 73, no. 1 (1999): 684–94. http://dx.doi.org/10.1128/jvi.73.1.684-694.1999.

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ABSTRACT We have studied the effects of CC-chemokines on human immunodeficiency virus type 1 (HIV-1) infection, focusing on the infectivity enhancement caused by RANTES. High RANTES concentrations increase the infectivity of HIV-1 isolates that use CXC-chemokine receptor 4 for entry. However, RANTES can have a similar enhancing effect on macrophagetropic viruses that enter via CC-chemokine receptor 5 (CCR5), despite binding to the same receptor as the virus. Furthermore, RANTES enhances the infectivity of HIV-1 pseudotyped with the envelope glycoprotein of murine leukemia virus or vesicular st

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Dairaghi, Daniel J., Kenneth S. Soo, Elizabeth R. Oldham, et al. "RANTES-Induced T Cell Activation Correlates with CD3 Expression." Journal of Immunology 160, no. 1 (1998): 426–33. http://dx.doi.org/10.4049/jimmunol.160.1.426.

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Abstract The chemokine RANTES induces a unique biphasic cytoplasmic Ca2+ signal in T cells. The first phase of this signal, similar to that of other chemokines, is G-protein mediated and chemotaxis associated. The second phase of this signal, unique to RANTES and evident at concentrations greater than 100 nM, is tyrosine kinase linked and results in a spectrum of responses similar to those seen with antigenic stimulation of T cells. We show here that certain Jurkat T cells responded to RANTES solely through this latter pathway. A direct correlation between the RANTES-induced second phase respo

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von Hundelshausen, Philipp, Rory R. Koenen, Markus Sack, et al. "Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endothelium." Blood 105, no. 3 (2005): 924–30. http://dx.doi.org/10.1182/blood-2004-06-2475.

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AbstractThe chemokines platelet factor 4 (PF4) and RANTES (regulated on activation normal T cell expressed and secreted) are secreted by activated platelets and influence multiple cell types and biologic processes. For instance, PF4 inhibits progenitor cell proliferation and angiogenesis, while platelet-derived RANTES is involved in vascular recruitment of monocytes. However, little is known about functional interactions of PF4 and RANTES. Here we show that the presence of PF4 enhanced the arrest of RANTES-stimulated monocytes and monocytic cells on activated endothelial cells under flow condi

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Allen, Jerilyn S., Roselle Eisma, Gerald Leonard, Denis Lafreniere, and Donald Kreutzer. "Characterization of the Eosinophil Chemokine Rantes in Nasal Polyps." Annals of Otology, Rhinology & Laryngology 107, no. 5 (1998): 416–20. http://dx.doi.org/10.1177/000348949810700510.

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Previous studies have demonstrated that the cytokine RANTES (Regulated And Normal T cell Expressed and Secreted) has been shown to be a potent mediator of eosinophil Chemotaxis in vitro and of leukocyte recruitment. Because eosinophils are the hallmark cells in nasal polyposis, we hypothesize that RANTES is locally produced within the nasal polyp microenvironment and is responsible for the eosinophil recruitment seen in nasal polyposis. To begin to test this hypothesis, we evaluated nasal polyps from 17 patients and 3 control specimens for distribution and content of RANTES using immunohistoch

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Jang, Yangsoo, Jey Sook Chae, Yae Jung Hyun, et al. "The RANTES −403G>A promoter polymorphism in Korean men: association with serum RANTES concentration and coronary artery disease." Clinical Science 113, no. 8 (2007): 349–56. http://dx.doi.org/10.1042/cs20070014.

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In the present study we investigated the association of the RANTES (regulated upon activation, normal T-cell expressed and secreted) −28C>G and −403G>A promoter polymorphisms with the concentration of serum RANTES and CAD (coronary artery disease) in Korean men. We included 553 male CAD patients with (n=176) or without (n=377) Type 2 diabetes, aged 40–65 years with previous myocardial infarction (∼50%) or angiographically confirmed CAD (∼50%), and 416 aged-matched healthy male controls. The main outcome measures were the OR (odds ratio) of CAD risk and the serum RANTES concentration eval

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Yano, Shozo, Romuald Mentaverri, Deepthi Kanuparthi та ін. "Functional Expression of β-Chemokine Receptors in Osteoblasts: Role of Regulated upon Activation, Normal T Cell Expressed and Secreted (RANTES) in Osteoblasts and Regulation of Its Secretion by Osteoblasts and Osteoclasts". Endocrinology 146, № 5 (2005): 2324–35. http://dx.doi.org/10.1210/en.2005-0065.

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Abstract The expression and functions of receptors for the β-chemokine, regulated upon activation, normal T cell expressed, and secreted (RANTES)/CCL5, were investigated in osteoblasts. Both primary osteoblasts and the MC3T3-E1 osteoblast cell line express the RANTES receptors, CCR1, 3, 4, and 5 (by RT-PCR), which encode functional receptors in osteoblasts as shown by [125I]-RANTES binding followed by Scatchard analysis. Expression of all four RANTES receptor mRNAs in osteoblast is in contrast to the reports of expression of CCR1 being the only RANTES receptor expressed by osteoclasts. Exogeno

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Ayad, Onsy, James M. Stark, Michael M. Fiedler, Ingrid Y. Menendez, Marnie A. Ryan, and Hector R. Wong. "The Heat Shock Response Inhibits RANTES Gene Expression in Cultured Human Lung Epithelium." Journal of Immunology 161, no. 5 (1998): 2594–99. http://dx.doi.org/10.4049/jimmunol.161.5.2594.

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Abstract The chemokine RANTES is thought to be involved in the pathophysiology of inflammation-associated acute lung injury. Although much is known regarding signals that induce RANTES gene expression, relatively few data exist regarding signals that inhibit RANTES gene expression. The heat shock response, a highly conserved cellular defense mechanism, has been demonstrated to inhibit a variety of lung proinflammatory responses. We tested the hypothesis that induction of the heat shock response inhibits RANTES gene expression. Treatment of A549 cells with TNF-α induced RANTES gene expression i

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Terao, Satoshi. "Chemokine RANTES in brain infarction." Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 28, no. 2 (2017): 327–31. http://dx.doi.org/10.16977/cbfm.28.2_327.

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Graziano, Frank M., Ellen B. Cook, and James L. Stahl. "Cytokines, Chemokines, RANTES, and Eotaxin." Allergy and Asthma Proceedings 20, no. 3 (1999): 141–46. http://dx.doi.org/10.2500/108854199778553055.

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SNOWDEN, N. "RANTES role in rheumatoid arthritis." Lancet 343, no. 8896 (1994): 547–48. http://dx.doi.org/10.1016/s0140-6736(94)91503-2.

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Arenberger, Petr, Peter Nelson, Anil Abraham, and Richard O. Leder. "Anti-rantes immunoreactivity in skin." Journal of Dermatological Science 6, no. 1 (1993): 72. http://dx.doi.org/10.1016/0923-1811(93)91127-g.

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Bai, Bingxue, Keiko Tanaka, Takahiro Tazawa, Naoko Yamamoto, and Hisashi Sugiura. "Association between RANTES promoter polymorphism −401A and enhanced RANTES production in atopic dermatitis patients." Journal of Dermatological Science 39, no. 3 (2005): 189–91. http://dx.doi.org/10.1016/j.jdermsci.2005.06.003.

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Signoret, Nathalie, Annegret Pelchen-Matthews, Matthias Mack, Amanda E. I. Proudfoot, and Mark Marsh. "Endocytosis and Recycling of the HIV Coreceptor Ccr5." Journal of Cell Biology 151, no. 6 (2000): 1281–94. http://dx.doi.org/10.1083/jcb.151.6.1281.

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The chemokine receptor CCR5 is a cofactor for the entry of R5 tropic strains of human immunodeficiency viruses (HIV)-1 and -2 and simian immunodeficiency virus. Cells susceptible to infection by these viruses can be protected by treatment with the CCR5 ligands regulated on activation, normal T cell expressed and secreted (RANTES), MIP-1α, and MIP-1β. A major component of the mechanism through which chemokines protect cells from HIV infection is by inducing endocytosis of the chemokine receptor. Aminooxypentane (AOP)-RANTES, an NH2-terminal modified form of RANTES, is a potent inhibitor of infe

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Vila-Coro, Antonio J., Mario Mellado, Ana Martín de Ana, Carlos Martínez-A., and José Miguel Rodríguez-Frade. "Characterization of RANTES- and Aminooxypentane-RANTES- Triggered Desensitization Signals Reveals Differences in Recruitment of the G Protein-Coupled Receptor Complex." Journal of Immunology 163, no. 6 (1999): 3037–44. http://dx.doi.org/10.4049/jimmunol.163.6.3037.

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Abstract The trafficking of lymphocyte populations is a complex process controlled by a vast array of molecules. In this process, cells must be able to sense small changes in chemoattractant gradients. Migration through a chemotactic gradient probably employs an on-off mechanism in which chemokine receptor desensitization, internalization, and recycling may be important steps. This multistep process requires the coordinated action of many factors, including G protein-coupled receptor kinases, arrestins, clathrin, and GTP-hydrolyzing proteins such as dynamin. In this report, we show that RANTES

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Koper-Lenkiewicz, Olga M., Joanna Kamińska, Anna Lisowska, Anna Milewska, Tomasz Hirnle, and Violetta Dymicka-Piekarska. "Factors Associated with RANTES Concentration in Cardiovascular Disease Patients." BioMed Research International 2019 (July 18, 2019): 1–11. http://dx.doi.org/10.1155/2019/3026453.

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Objective.The aim of the study was to establish, by means of linear regressions analysis, whether RANTES and CCL2 have a relationship with age, sex, heart rate, ejection fraction, white blood cells count, monocyte count, platelet count, mean platelet volume, hsCRP concentration, creatinine and eGFR value, applied treatments, and coronary risk factors in polish cardiovascular disease patients.Methods.Plasma chemokines concentrations were measured by ELISA method (R&D Systems Europe Ltd., Abingdon, England) in 115 cardiovascular disease patients (83 myocardial infarction/AMI and 32 stable an

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Alam, R., S. Stafford, P. Forsythe, et al. "RANTES is a chemotactic and activating factor for human eosinophils." Journal of Immunology 150, no. 8 (1993): 3442–48. http://dx.doi.org/10.4049/jimmunol.150.8.3442.

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Abstract RANTES is a member of the 8-kDa cytokine family that has been shown to possess chemotactic activity for monocytes and CD4 T cells. In this study, we investigated whether RANTES could affect eosinophil chemotaxis and function. Peripheral blood eosinophils from blood donors were isolated on Percoll gradients to &gt; 98% purity and then used for chemotaxis, flow cytometry, eosinophil cationic protein release assay, and survival assay. We found that RANTES is chemotactic for eosinophils at 10(-9) to 10(-8) M concentrations. RANTES elicited 65% of the chemotactic response to 10(-7) M p

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Sabbe, Rebecca, Gastón R. Picchio, Cristina Pastore, et al. "Donor- and Ligand-Dependent Differences in C-C Chemokine Receptor 5 Reexpression." Journal of Virology 75, no. 2 (2001): 661–71. http://dx.doi.org/10.1128/jvi.75.2.661-671.2001.

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ABSTRACT N-terminal modifications of the chemokine RANTES bind to C-C chemokine receptor 5 (CCR5) and block human immunodeficiency virus type 1 (HIV-1) infection with greater efficacy than native RANTES. Modified RANTES compounds induce rapid CCR5 internalization and much slower receptor reexpression than native RANTES, suggesting that receptor sequestration is one mode of anti-HIV activity. The rates of CCR5 internalization and reexpression were compared using the potentn-nonanoyl (NNY)-RANTES derivative and CD4+ T cells derived from donors with different CCR5 gene polymorphisms. NNY-RANTES c

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Casola, Antonella, Allyne Henderson, Tianshuang Liu, Roberto P. Garofalo, and Allan R. Brasier. "Regulation of RANTES promoter activation in alveolar epithelial cells after cytokine stimulation." American Journal of Physiology-Lung Cellular and Molecular Physiology 283, no. 6 (2002): L1280—L1290. http://dx.doi.org/10.1152/ajplung.00162.2002.

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Regulated on activation, normal T cell expressed, and presumably secreted (RANTES) is a member of the CC chemokine family of proteins implicated in a variety of diseases characterized by lung eosinophilia and inflammation, strongly produced by stimulated airway epithelial cells. Because such cytokines as tumor necrosis factor (TNF)-α and interferon-γ (IFN-γ) have been shown to enhance RANTES induction in airway epithelial cells and RANTES gene expression appears to be differentially regulated depending on the cell type and the stimulus applied, in this study we have elucidated mechanisms that

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Pan, Zhong-Zong, Lisa Parkyn, Anuradha Ray, and Prabir Ray. "Inducible lung-specific expression of RANTES: preferential recruitment of neutrophils." American Journal of Physiology-Lung Cellular and Molecular Physiology 279, no. 4 (2000): L658—L666. http://dx.doi.org/10.1152/ajplung.2000.279.4.l658.

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The chemokine regulated on activation normal T cells expressed and secreted (RANTES) has been implicated in eosinophil chemotaxis in asthma and allergic diseases, which are thought to be T helper (Th) type 2-dominated diseases. However, adoptive transfer of Th1 cells in mice upregulates RANTES gene expression in the lung, and increased RANTES expression has been documented in several Th1 cell-dominated conditions that are associated with neutrophilia. The in vivo role of RANTES in the pathogenesis of disease processes is not well understood. To determine the effect of RANTES expression alone i

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Baltus, Thomas, Kim S. C. Weber, Zoë Johnson, Amanda E. I. Proudfoot, and Christian Weber. "Oligomerization of RANTES is required for CCR1-mediated arrest but not CCR5-mediated transmigration of leukocytes on inflamed endothelium." Blood 102, no. 6 (2003): 1985–88. http://dx.doi.org/10.1182/blood-2003-04-1175.

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Abstract Chemokines control inflammatory leukocyte recruitment. The propensity of chemokines such as CC chemokine ligand 5 (CCL5)/RANTES (regulated on activation, normal T cell expressed and secreted) to bind to glycosaminoglycans and to form higher order oligomers has been shown to be essential for its in vivo activity. However, the specific functional relevance of RANTES oligomerization for distinct steps of leukocyte recruitment on inflamed endothelium mediated by the RANTES receptors CC chemokine receptor 1 (CCR1) and CCR5 remains undefined. We studied RANTES mutants with deficient oligome

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Tereshchenko, Irina P., Jana Petrkova, Mikhail I. Voevoda, et al. "CCL5/RANTES Gene Polymorphisms in Slavonic Patients with Myocardial Infarction." Mediators of Inflammation 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/525691.

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Coronary artery inflammation is a critical process in the pathogenesis of myocardial infarction (MI). The chemokine CCL5/RANTES (regulated upon activation, normal T cells expressed and secreted) is expressed in advanced atherosclerotic lesions. Functional polymorphisms of the RANTES gene can, therefore, be involved in the pathogenesis of coronary artery disease. We examined the association of polymorphisms in the RANTES gene with myocardial infarction in Slavonic populations of Czech and Russian origin. A total of 467 post-MI patients and 337 control subjects were genotyped for RANTES promoter

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Nelson, P. J., H. T. Kim, W. C. Manning, T. J. Goralski, and A. M. Krensky. "Genomic organization and transcriptional regulation of the RANTES chemokine gene." Journal of Immunology 151, no. 5 (1993): 2601–12. http://dx.doi.org/10.4049/jimmunol.151.5.2601.

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Abstract RANTES is a member of a large supergene family of pro-inflammatory cytokines called CC chemokines that appear to play a fundamental role in inflammatory processes. The RANTES protein causes release of histamine from basophils and is a chemoattractant for CD45RO/CD4+ "memory" T lymphocytes, monocytes, and eosinophils. Although expression of RANTES was first thought to be limited to activated T cells, recent data have shown that it is produced by a variety of tissue types in response to specific stimuli. RANTES mRNA is expressed late (3 to 5 days) after activation of resting T cells whe

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Turner, L., S. G. Ward, and J. Westwick. "RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase." Journal of Immunology 155, no. 5 (1995): 2437–44. http://dx.doi.org/10.4049/jimmunol.155.5.2437.

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Abstract RANTES (regulated on activation, normal T cell expressed and secreted), a member of the chemokine family, is a potent chemoattractant for CD4+/CD45RO human T lymphocytes, but the signal-transduction mechanisms utilized by RANTES are poorly defined. In freshly isolated human T lymphocytes loaded with fura-2 acetoxymethyl, the CD3 mAb, UCHT-1, but not RANTES, elicited elevation of intracellular calcium levels. However, RANTES produced a bell-shaped chemotactic response and an increase in polarization of the T lymphocytes. Immunoprecipitates of phosphoinositide (PI) 3-kinase, derived fro

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Oran, Paul E., Nisha D. Sherma, Chad R. Borges, Jason W. Jarvis, and Randall W. Nelson. "Intrapersonal and Populational Heterogeneity of the Chemokine RANTES." Clinical Chemistry 56, no. 9 (2010): 1432–41. http://dx.doi.org/10.1373/clinchem.2010.147884.

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BACKGROUND Current immunoassays for the chemokine RANTES (regulated on activation, normal T-cell expressed and secreted) are not tailored for specific isoforms that exist endogenously, despite the fact that variants with modified activity are known to exist. This is surprising in view of this protein’s ubiquitous increased presence in many diseases and that the 2 established isoforms are truncated by enzymes also correlated to disease. An in-depth population survey of RANTES heterogeneity in the context of multiple diseases via a mass spectrometric immunoassay (MSIA) may resolve this issue. ME

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YING, S., Q. MENG, L. TABORDABARATA, et al. "242 Human eosinophils (Eos) express RANTES mRNA and store and release biologically active RANTES protein." Journal of Allergy and Clinical Immunology 97, no. 1 (1996): 243. http://dx.doi.org/10.1016/s0091-6749(96)80460-x.

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Schols, Dominique, Paul Proost, Sofie Struyf, et al. "CD26-processed RANTES(3–68), but not intact RANTES, has potent anti-HIV-1 activity." Antiviral Research 39, no. 3 (1998): 175–87. http://dx.doi.org/10.1016/s0166-3542(98)00039-4.

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Westerweel, Peter, Ton Rabelink, Maarten Rookmaaker, Hermann-Josef Gröne, and Marianne Verhaar. "RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy." Thrombosis and Haemostasis 99, no. 04 (2008): 794–95. http://dx.doi.org/10.1160/th07-10-0628.

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Ying, Sun, Qiu Meng, Luis Taborda-Barata, et al. "Human eosinophils express messenger RNA encoding RANTES and store and release biologically active RANTES protein." European Journal of Immunology 26, no. 1 (1996): 70–76. http://dx.doi.org/10.1002/eji.1830260111.

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Terada, N., K. Maesako, N. Hamano, et al. "Eosinophil adhesion regulates RANTES production in nasal epithelial cells." Journal of Immunology 158, no. 11 (1997): 5464–70. http://dx.doi.org/10.4049/jimmunol.158.11.5464.

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Abstract (sommario):

Abstract Among the many known chemotactic factors for eosinophils, the proinflammatory chemokine RANTES is particularly important, because it is potently and selectively chemotactic for eosinophils. Throughout the process of the migration of eosinophils from the blood vessels into the nasal cavity, eosinophil functions are assumed to be regulated by surface adhesion molecules. Conversely, the messages conferred by the eosinophils to the endothelial and epithelial cells are also of great interest. In the present study, we showed that eosinophil adhesion to human nasal epithelial cells (HNECs) i

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40

Wei, Jin-Hua, Xiao Feng, Zhi-Jian Sun, et al. "Different locations of RANTES and its receptors on mouse epididymal spermatozoa." Reproduction, Fertility and Development 28, no. 10 (2016): 1509. http://dx.doi.org/10.1071/rd14231.

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Abstract (sommario):

Our previous study showed that the chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) originating from the mouse epididymis bound to the midpiece of luminal spermatozoa. The present study was undertaken to investigate the association between RANTES and epididymal spermatozoa and to determine whether the association is mediated by the RANTES receptors CCR1, CCR3 or CCR5. The use of reverse transcription polymerase chain reaction (RT-PCR), immunohistochemical staining and immunofluorescent staining demonstrated that RANTES secreted by apical and narrow cells of mou

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41

Hariharan, Deepa, Wenzhe Ho, Joann Cutilli, Donald E. Campbell, and Steven D. Douglas. "C-C chemokine profile of cord blood mononuclear cells: selective defect in RANTES production." Blood 95, no. 2 (2000): 715–18. http://dx.doi.org/10.1182/blood.v95.2.715.

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Abstract (sommario):

Three C-C chemokines inhibit human immunodeficiency virus (HIV) entry into macrophages: macrophage inflammatory protein-1 (MIP-1), MIP-1β, and regulated-upon activation, normal T-cell expressed and secreted (RANTES). We studied the ability of placental cord blood mononuclear cells (CBMC) to secrete these C-C chemokines in comparison to adult blood mononuclear cells (ABMC). CBMC had diminished ability to secrete RANTES, as determined by enzyme-linked immunosorbent assay. Secretion of MIP-1 and MIP-1β were similar in CBMC and ABMC. Whereas MIP-1 and MIP-1β secretion were comparable in monocy

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42

Holms, Rupert. "The therapeutic potential of RANTES/CCL5 across diverse infections and its synergistic enhancement by ezrin peptide RepG3 for long COVID." Microbes & Immunity 1, no. 1 (2024): 2474. http://dx.doi.org/10.36922/mi.2474.

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Abstract (sommario):

The amplification of anti-infective immunity against a wide spectrum of acute and chronic infections caused by various pathogens is mediated by RANTES/CCL5. This chemokine controls infections caused by viruses, bacteria, fungi, and protozoans. In addition, RANTES/CCL5 exhibits anti-cancer effects by increasing NK-cell activity and targeting tumors. RANTES/CCL5 acts by amplifying antigen-specific immunity on mucosal surfaces, programmed T-cell responses, cytotoxic T lymphocytes (CTL), B-cell activation, and antibody production. RANTES/CCL5 exerts its effects by binding to C-C receptors, thereby

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43

Baturcam, Engin, Jehad Abubaker, Ali Tiss, et al. "Physical Exercise Reduces the Expression of RANTES and Its CCR5 Receptor in the Adipose Tissue of Obese Humans." Mediators of Inflammation 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/627150.

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Abstract (sommario):

RANTES and its CCR5 receptor trigger inflammation and its progression to insulin resistance in obese. In the present study, we investigated for the first time the effect of physical exercise on the expression of RANTES and CCR5 in obese humans. Fifty-seven adult nondiabetic subjects (17 lean and 40 obese) were enrolled in a 3-month supervised physical exercise. RANTES and CCR5 expressions were measured in PBMCs and subcutaneous adipose tissue before and after exercise. Circulating plasma levels of RANTES were also investigated. There was a significant increase in RANTES and CCR5 expression in

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44

Chang, Theresa Li-Yun, Cynthia J. Gordon, Branka Roscic-Mrkic, et al. "Interaction of the CC-Chemokine RANTES with Glycosaminoglycans Activates a p44/p42 Mitogen-Activated Protein Kinase-Dependent Signaling Pathway and Enhances Human Immunodeficiency Virus Type 1 Infectivity." Journal of Virology 76, no. 5 (2002): 2245–54. http://dx.doi.org/10.1128/jvi.76.5.2245-2254.2002.

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Abstract (sommario):

ABSTRACT The interaction of the CC-chemokine RANTES with its cell surface receptors transduces multiple intracellular signals: low concentrations of RANTES (1 to 10 nM) stimulate G-protein-coupled receptor (GPCR) activity, and higher concentrations (1 μM) activate a phosphotyrosine kinase (PTK)-dependent pathway. Here, we show that the higher RANTES concentrations induce rapid tyrosine phosphorylation of multiple proteins. Several src-family kinases (Fyn, Hck, Src) are activated, as is the focal adhesion kinase p125 FAK and, eventually, members of the p44/p42 mitogen-activated protein kinase (

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45

Stellato, C., L. A. Beck, G. A. Gorgone, et al. "Expression of the chemokine RANTES by a human bronchial epithelial cell line. Modulation by cytokines and glucocorticoids." Journal of Immunology 155, no. 1 (1995): 410–18. http://dx.doi.org/10.4049/jimmunol.155.1.410.

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Abstract (sommario):

Abstract The chemokine RANTES is a potent chemoattractant for eosinophils, lymphocytes, and monocytes, and has been detected recently in the epithelium of human airways mucosa. We have studied, therefore, the expression of RANTES mRNA and protein in the human bronchial epithelial cell line BEAS-2B. Using Northern blot analysis, RANTES mRNA was not detectable in unstimulated BEAS-2B cells. Incubation of cells with TNF-alpha or IFN-gamma induced the expression of RANTES mRNA and protein within 16 h. The combination of TNF-alpha and IFN-gamma displayed a marked synergism in inducing RANTES expres

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46

Ebisawa, M., T. Yamada, C. Bickel, D. Klunk, and R. P. Schleimer. "Eosinophil transendothelial migration induced by cytokines. III. Effect of the chemokine RANTES." Journal of Immunology 153, no. 5 (1994): 2153–60. http://dx.doi.org/10.4049/jimmunol.153.5.2153.

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Abstract (sommario):

Abstract Selective eosinophil recruitment occurs after experimental Ag challenge and in tissue sites of allergic diseases. The mechanisms of selective eosinophil migration are still unknown. In our study, we examined the ability of chemokines to induce transendothelial migration (TEM) of eosinophils in vitro. Among the chemokines tested, only RANTES induced eosinophil TEM. RANTES failed to induce TEM of neutrophils. Interestingly, IL-8 induced neutrophil TEM and had no effect on eosinophil TEM. RANTES-induced TEM was concentration-dependent and was inhibited by Abs directed against the beta 2

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47

Marleau, S., D. A. Griffiths-Johnson, P. D. Collins, Y. S. Bakhle, T. J. Williams, and P. J. Jose. "Human RANTES acts as a receptor antagonist for guinea pig eotaxin in vitro and in vivo." Journal of Immunology 157, no. 9 (1996): 4141–46. http://dx.doi.org/10.4049/jimmunol.157.9.4141.

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Abstract (sommario):

Abstract The guinea pig C-C chemokine, eotaxin, is a potent and selective eosinophil chemoattractant in guinea pig airways and skin in vivo, and stimulates both guinea pig and human eosinophils in vitro. The human C-C chemokine RANTES (30% homology with guinea pig eotaxin) stimulates human eosinophils in vitro, but does not stimulate guinea pig eosinophils, even though these cells bind 125I-RANTES. Similar concentrations of eotaxin and unlabeled RANTES competitively inhibit the binding of 125I-RANTES to guinea pig eosinophils, suggesting that eotaxin and RANTES share a common binding site on t

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48

Ahn, Yong-Tae, Boli Huang, Lisa McPherson, Carol Clayberger, and Alan M. Krensky. "Dynamic Interplay of Transcriptional Machinery and Chromatin Regulates “Late” Expression of the Chemokine RANTES in T Lymphocytes." Molecular and Cellular Biology 27, no. 1 (2007): 253–66. http://dx.doi.org/10.1128/mcb.01071-06.

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Abstract (sommario):

ABSTRACT The chemokine RANTES (regulated upon activation normal T cell expressed and secreted) is expressed “late” (3 to 5 days) after activation in T lymphocytes. In order to understand the molecular events that accompany changes in gene expression, a detailed analysis of the interplay between transcriptional machinery and chromatin on the RANTES promoter over time was undertaken. Krüppel-like factor 13 (KLF13), a sequence-specific DNA binding transcription factor, orchestrates the induction of RANTES expression in T lymphocytes by ordered recruitment of effector molecules, including Nemo-li

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49

Schall, T. J., J. Jongstra, B. J. Dyer, et al. "A human T cell-specific molecule is a member of a new gene family." Journal of Immunology 141, no. 3 (1988): 1018–25. http://dx.doi.org/10.4049/jimmunol.141.3.1018.

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Abstract (sommario):

Abstract We have used a cDNA library enriched for T cell-specific sequences to isolate genes expressed by T cells but not by other cell types. We report here one such gene, designated RANTES, which encodes a novel T cell-specific molecule. The RANTES gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. RANTES is expressed by cultured T cell lines that are Ag specific and growth factor dependent. RANTES expression is inducible in PBL by Ag or mitogen. In CTL,

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50

Wang, J. M., D. W. McVicar, J. J. Oppenheim, and D. J. Kelvin. "Identification of RANTES receptors on human monocytic cells: competition for binding and desensitization by homologous chemotactic cytokines." Journal of Experimental Medicine 177, no. 3 (1993): 699–705. http://dx.doi.org/10.1084/jem.177.3.699.

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Abstract (sommario):

RANTES (regulated on activation, normal T expressed and secreted) is a member of the chemotactic cytokine (chemokine) beta subfamily. High affinity receptors for RANTES have been identified on a human monocytic leukemia cell line THP-1, which responded to RANTES in chemotaxis and calcium mobilization assays. Steady-state binding data analyses revealed approximately 700 binding sites/cell on THP-1 cells with a Kd value of 400 pM, comparable to that expressed on human peripheral blood monocytes. The RANTES binding to monocytic cells was competed for by monocyte chemotactic and activating factor

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