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Bibliografie tematiche / Reggie-1

Letteratura scientifica selezionata sul tema "Reggie-1"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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Articoli di riviste sul tema "Reggie-1":

1

Solis, Gonzalo P., Nikola Hülsbusch, Yvonne Radon, Vladimir L. Katanaev, Helmut Plattner e Claudia A. O. Stuermer. "Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking". Molecular Biology of the Cell 24, n. 17 (settembre 2013): 2689–702. http://dx.doi.org/10.1091/mbc.e12-12-0854.

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Abstract (sommario):

The lipid raft proteins reggie-1 and -2 (flotillins) are implicated in membrane protein trafficking but exactly how has been elusive. We find that reggie-1 and -2 associate with the Rab11a, SNX4, and EHD1–decorated tubulovesicular recycling compartment in HeLa cells and that reggie-1 directly interacts with Rab11a and SNX4. Short hairpin RNA–mediated down-regulation of reggie-1 (and -2) in HeLa cells reduces association of Rab11a with tubular structures and impairs recycling of the transferrin–transferrin receptor (TfR) complex to the plasma membrane. Overexpression of constitutively active Rab11a rescues TfR recycling in reggie-deficient HeLa cells. Similarly, in a Ca2+ switch assay in reggie-depleted A431 cells, internalized E-cadherin is not efficiently recycled to the plasma membrane upon Ca2+ repletion. E-cadherin recycling is rescued, however, by overexpression of constitutively active Rab11a or SNX4 in reggie-deficient A431 cells. This suggests that the function of reggie-1 in sorting and recycling occurs in association with Rab11a and SNX4. Of interest, impaired recycling in reggie-deficient cells leads to de novo E-cadherin biosynthesis and cell contact reformation, showing that cells have ways to compensate the loss of reggies. Together our results identify reggie-1 as a regulator of the Rab11a/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved.

2

NEUMANN-GIESEN, Carolin, Bianca FALKENBACH, Peter BEICHT, Stephanie CLAASEN, Georg LÜERS, Claudia A. O. STUERMER, Volker HERZOG e Ritva TIKKANEN. "Membrane and raft association of reggie-1/flotillin-2: role of myristoylation, palmitoylation and oligomerization and induction of filopodia by overexpression". Biochemical Journal 378, n. 2 (1 marzo 2004): 509–18. http://dx.doi.org/10.1042/bj20031100.

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The reggie protein family consists of two proteins, reggie-1 and -2, also called flotillins, which are highly ubiquitous and evolutionarily conserved. Both reggies have been shown to be associated with membrane rafts and are involved in various cellular processes such as T-cell activation, phagocytosis and insulin signalling. However, the exact molecular function of these proteins remains to be determined. In addition, the mechanism of membrane association of reggie-1, which does not contain any transmembrane domain, is not known. In this study, we have produced a fusion protein of reggie-1 with enhanced green fluorescent protein and generated targeted substitutions for the inactivation of putative palmitoylation and myristoylation sites. We were able to show that reggie-1 is myristoylated and multiply palmitoylated and that lipid modifications are necessary for membrane association of reggie-1. Overexpression of reggie-1 resulted in the induction of numerous filopodia-like protrusions in various cell lines, suggesting a role for reggie-1 as a signalling protein in actin-dependent processes.

3

Stuermer, Claudia A. O., e Helmut Plattner. "The 'lipid raft' microdomain proteins reggie-1 and reggie-2 (flotillins) are scaffolds for protein interaction and signalling." Biochemical Society Symposia 72 (1 gennaio 2005): 109–18. http://dx.doi.org/10.1042/bss0720109.

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Reggie-1 and reggie-2 are two evolutionarily highly conserved proteins which are up-regulated in retinal ganglion cells during regeneration of lesioned axons in the goldfish optic nerve. They are located at the cytoplasmic face of the plasma membrane and are considered to be 'lipid raft' constituents due to their insolubility in Triton X-100 and presence in the 'floating fractions'; hence they were independently named flotillins. According to our current view, the reggies subserve functions as protein scaffolds which form microdomains in neurons, lymphocytes and many other cell types across species as distant as flies and humans. These microdomains are of a surprisingly constant size of less than or equal to 0.1 mm in all cell types, whereas the distance between them is variable. The microdomains co-ordinate signal transduction of specific cell-surface proteins and especially of GPI (glycosylphosphatidylinositol)-anchored proteins into the cell, as is demonstrated for PrPc (cellular prion protein) in T-lymphocytes. These cells possess a pre-formed reggie cap scaffold consisting of densely packed reggie microdomains. PrPc is targeted to the lymphocyte reggie cap when activated by antibody cross-linking, and induces a distinct Ca2+ signal. In developing zebrafish, reggies become concentrated in neurons and axon tracts, and their absence, after morpholino antisense RNA-knockdown, results in deformed embryos with reduced brains. Likewise, defects in Drosophila eye morphogenesis occur upon reggie overexpression in mutant flies. The defects observed in the organism, as well as in single cells in culture, indicate a morphogenetic function of the reggies, with emphasis on the nervous system. This complies with their role as scaffolds for the formation of multiprotein complexes involved in signalling across the plasma membrane.

4

Solis, Gonzalo P., Maja Hoegg, Christina Munderloh, Yvonne Schrock, Edward Malaga-Trillo, Eric Rivera-Milla e Claudia A. O. Stuermer. "Reggie/flotillin proteins are organized into stable tetramers in membrane microdomains". Biochemical Journal 403, n. 2 (26 marzo 2007): 313–22. http://dx.doi.org/10.1042/bj20061686.

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Reggie-1 and -2 proteins (flotillin-2 and -1 respectively) form their own type of non-caveolar membrane microdomains, which are involved in important cellular processes such as T-cell activation, phagocytosis and signalling mediated by the cellular prion protein and insulin; this is consistent with the notion that reggie microdomains promote protein assemblies and signalling. While it is generally known that membrane microdomains contain large multiprotein assemblies, the exact organization of reggie microdomains remains elusive. Using chemical cross-linking approaches, we have demonstrated that reggie complexes are composed of homo- and hetero-tetramers of reggie-1 and -2. Moreover, native reggie oligomers are indeed quite stable, since non-cross-linked tetramers are resistant to 8 M urea treatment. We also show that oligomerization requires the C-terminal but not the N-terminal halves of reggie-1 and -2. Using deletion constructs, we analysed the functional relevance of the three predicted coiled-coil stretches present in the C-terminus of reggie-1. We confirmed experimentally that reggie-1 tetramerization is dependent on the presence of coiled-coil 2 and, partially, of coiled-coil 1. Furthermore, since depletion of reggie-1 by siRNA (small interfering RNA) silencing induces proteasomal degradation of reggie-2, we conclude that the protein stability of reggie-2 depends on the presence of reggie-1. Our data indicate that the basic structural units of reggie microdomains are reggie homo- and hetero-tetramers, which are dependent on the presence of reggie-1.

5

Stuermer, Claudia A. O., Dirk M. Lang, Friederike Kirsch, Marianne Wiechers, Sören-Oliver Deininger e Helmut Plattner. "Glycosylphosphatidyl Inositol-anchored Proteins and fyn Kinase Assemble in Noncaveolar Plasma Membrane Microdomains Defined by Reggie-1 and -2". Molecular Biology of the Cell 12, n. 10 (ottobre 2001): 3031–45. http://dx.doi.org/10.1091/mbc.12.10.3031.

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Using confocal laser scanning and double immunogold electron microscopy, we demonstrate that reggie-1 and -2 are colocalized in ≤0.1-μm plasma membrane microdomains of neurons and astrocytes. In astrocytes, reggie-1 and -2 do not occur in caveolae but clearly outside these structures. Microscopy and coimmunoprecipitation show that reggie-1 and -2 are associated with fyn kinase and with the glycosylphosphatidyl inositol-anchored proteins Thy-1 and F3 that, when activated by antibody cross-linking, selectively copatch with reggie. Jurkat cells, after cross-linking of Thy-1 or GM1 (with the use of cholera toxin), exhibit substantial colocalization of reggie-1 and -2 with Thy-1, GM1, the T-cell receptor complex and fyn. This, and the accumulation of reggie proteins in detergent-resistant membrane fractions containing F3, Thy-1, and fyn imparts to reggie-1 and -2 properties of raft-associated proteins. It also suggests that reggie-1 and -2 participate in the formation of signal transduction centers. In addition, we find reggie-1 and -2 in endolysosomes. In Jurkat cells, reggie-1 and -2 together with fyn and Thy-1 increase in endolysosomes concurrent with a decrease at the plasma membrane. Thus, reggie-1 and -2 define raft-related microdomain signaling centers in neurons and T cells, and the protein complex involved in signaling becomes subject to degradation.

6

Schulte, T., K. A. Paschke, U. Laessing, F. Lottspeich e C. A. Stuermer. "Reggie-1 and reggie-2, two cell surface proteins expressed by retinal ganglion cells during axon regeneration". Development 124, n. 2 (15 gennaio 1997): 577–87. http://dx.doi.org/10.1242/dev.124.2.577.

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Fish--in contrast to mammals--regenerate retinal ganglion cell axons when the optic nerve is severed. Optic nerve injury leads to reexpression of proteins, which typically are first expressed in newly differentiated retinal ganglion cells and axons. Here we identified two new proteins of fish retinal ganglion cells, reggie-1 and reggie-2, with monoclonal antibody M802 and molecular cloning techniques. In normal fish, M802 stained the few retinal axons derived from newborn ganglion cells which in fish are added lifelong to the retinal margin. After optic nerve injury, however, M802 labeled all retinal ganglion cells and retinal axons throughout their path into tectum. Consistent with M802 staining, reggie-1 and reggie-2 mRNAs were present in lesioned retinal ganglion cells, as demonstrated by in situ hybridization, but were not detectable in their normal mature counterparts. In western blots with membrane proteins of the adult goldfish brain, M802 recognizes a 48x10(3) Mr protein band. At the amino acid level, 48x10(3) Mr reggie-1 and reggie-2 are 44% identical, lack transmembrane and membrane anchor domains, but appear membrane associated by ionic interactions. Reggie-1 and reggie-2 are homologous to 35x10(3) Mr ESA (human epidermal surface antigen) but are here identified as neuronal surface proteins, present on newly differentiated ganglion cells at the retinal margin and which are reexpressed in mature ganglion cells upon injury and during axonal regeneration.

7

Cornfine, Susanne, Mirko Himmel, Petra Kopp, Karim el Azzouzi, Christiane Wiesner, Marcus Krüger, Thomas Rudel e Stefan Linder. "The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes". Molecular Biology of the Cell 22, n. 2 (15 gennaio 2011): 202–15. http://dx.doi.org/10.1091/mbc.e10-05-0394.

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Podosomes are actin-based matrix contacts in a variety of cell types, most notably monocytic cells, and are characterized by their ability to lyse extracellular matrix material. Besides their dependence on actin regulation, podosomes are also influenced by microtubules and microtubule-dependent transport processes. Here we describe a novel role for KIF9, a previously little-characterized member of the kinesin motor family, in the regulation of podosomes in primary human macrophages. We find that small interfering RNA (siRNA)/short-hairpin RNA–induced knockdown of KIF9 significantly affects both numbers and matrix degradation of podosomes. Overexpression and microinjection experiments reveal that the unique C-terminal region of KIF9 is crucial for these effects, presumably through binding of specific interactors. Indeed, we further identify reggie-1/flotillin-2, a signaling mediator between intracellular vesicles and the cell periphery, as an interactor of the KIF9 C-terminus. Reggie-1 dynamically colocalizes with KIF9 in living cells, and, consistent with KIF9-mediated effects, siRNA-induced knockdown of reggies/flotillins significantly impairs matrix degradation by podosomes. In sum, we identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures.

8

Babuke, Tanja, Mika Ruonala, Melanie Meister, Monia Amaddii, Christina Genzler, Alessandro Esposito e Ritva Tikkanen. "Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis". Cellular Signalling 21, n. 8 (agosto 2009): 1287–97. http://dx.doi.org/10.1016/j.cellsig.2009.03.012.

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9

Langhorst, Matthias F., Alexander Reuter, Friederike A. Jaeger, Frank M. Wippich, Georg Luxenhofer, Helmut Plattner e Claudia A. O. Stuermer. "Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2". European Journal of Cell Biology 87, n. 4 (aprile 2008): 211–26. http://dx.doi.org/10.1016/j.ejcb.2007.12.001.

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10

Ismair, Manfred G., Stephanie Häusler, Claudia A. Stuermer, Christelle Guyot, Peter J. Meier, Jürgen Roth e Bruno Stieger. "ABC-transporters are localized in caveolin-1-positive and reggie-1-negative and reggie-2-negative microdomains of the canalicular membrane in rat hepatocytes". Hepatology 49, n. 5 (23 dicembre 2008): 1673–82. http://dx.doi.org/10.1002/hep.22807.

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Più fonti

Tesi sul tema "Reggie-1":

1

Rajendran, Lawrence, Marlen Knobloch, Kathrin D. Geiger, Stephanie Dienel, Roger Nitsch, Kai Simons e Uwe Konietzko. "Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-136570.

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Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich

2

Rajendran, Lawrence, Marlen Knobloch, Kathrin D. Geiger, Stephanie Dienel, Roger Nitsch, Kai Simons e Uwe Konietzko. "Increased Aβ Production Leads to Intracellular Accumulation of Aβ in Flotillin-1-Positive Endosomes". Karger, 2007. https://tud.qucosa.de/id/qucosa%3A27713.

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Extracellular accumulation of Aβ in β-amyloid plaques is thought to be associated with the neurodegeneration observed in Alzheimer’s disease (AD) patients, although a lack of correlation with cognitive decline raised doubts on this hypothesis. In different transgenic mouse models Aβ accumulates inside the cells and mice develop behavioral deficits well before visible extracellular β-amyloid accumulation. Here we show that intracellular Aβ accumulates in flotillin-1 positive endocytic vesicles. We also demonstrate that flotillin-1 is not only associated with intracellular Aβ in transgenic mice but also with extracellular β-amyloid plaques in AD patient brain sections.
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

3

ANDERSSON, MONICA. "”Barnens intresse styr över hur vi arbetar med naturvetenskap och teknik i förskolan” : En studie av förskollärarens sätt att beskriva hur de kan tillvarata och utveckla de yngsta barnens, 1–3 år, intresse för ämnena fysik och teknik". Thesis, Karlstads universitet, Institutionen för pedagogiska studier (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-71347.

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Syftet med denna studie är att få en fördjupad förståelse av hur en förskola kan arbeta med ämnena naturvetenskap och teknik på ett genomtänkt sätt. Avsikten med studien är också att bidra med mer kunskap om på vilka olika sätt pedagoger kan ta tillvara och utveckla barnens intresse för teknik och fysik. Studien är kvalitativ och har genomförts genom att studera dokumentation från sociala medier som den studerade förskolan publicerat. Dokumentationen har sedan varit en grund för de semistrukturerade intervjuer som genomfördes. För att komma fram till resultatet som gjorts har den fenomenografiska analysmodellen använts. Resultatet som framkom ifrån de tre intervjuer som gjordes, visar att pedagogerna på denna förskola inte ser några hinder med att arbeta med ämnena naturvetenskap och teknik med de allra yngsta barnen, 1–3 år, trots att de saknar en formell fördjupad utbildning inom ämnena. Pedagogerna ser bara möjligheter. Förskolan arbetar Reggio Emilia inspirerat och har arbetat fram en praktikgemenskap, där de skapar goda förutsättningar för undervisning i naturvetenskap och teknik.
The aim of this study is to gain an in-depth understanding of how a preschool can work with the subjects of science and technology in a well-thought-out way. The purpose of the study is also to provide more knowledge about which different ways pedagogues can use and develop the children's interest in technology and physics. The study is qualitative and has been carried out by studying documentation from social media published by the preschool. The documentation has since been a basis for the semi-structured interviews that were conducted. To reach the result, the phenomenographic analysis model has been used. The result shows that the three teachers interviewed at this preschool see no obstacles to working with the subjects of science and technology with the youngest children, 1-3 years, even though they lack a formal in-depth education in the subjects. The preschool teachers only see opportunities. To create the best conditions for teaching science and technology the preschool has worked out a community of practice inspired by Reggio Emilia.

4

Beicht, Peter [Verfasser]. "Interaktion von Reggie-2, Flotillin-1 mit HIV-1-Gag : funktionelle Aspekte der Assemblierung und Ausschleusung Virus-ähnlicher Partikel / von Peter Beicht". 2006. http://d-nb.info/979490502/34.

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Libri sul tema "Reggie-1":

1

Benati, Davide. Davide Benati: Terre d'ombre, Reggio Emilia, Saletta giardino Civici musei, 1/20 marzo 1986. Reggio Emilia: Comune di Reggio Emilia, Assessorato istituzioni culturali, Civici musei, 1986.

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2

Nobili, Umberto. Giannino Tamagnini: Reggio Emilia, Atrio Musei civici, via Spallanzani 1, 27 marzo-25 aprile 1999. Reggio Emilia]: Musei civici di Reggio Emilia, 1999.

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3

United States. Congress. Senate. Committee on the Judiciary. Confirmation hearings of federal appointments to the Office of National Drug Control Policy (Bennett, Walton, and Morris): Hearings before the Committee on the Judiciary, United States Senate, One Hundred First Congress, first session, on the nominations of Dr. William J. Bennett to be Director ..., Reggie B. Walton to be Associate Director, and Stanley E. Morris to be Deputy Director ... March 1, 2, June 6, and September 20, 1989. Washington: U.S. G.P.O., 1991.

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4

United States. Congress. Senate. Committee on the Judiciary. Confirmation hearings of federal appointments to the Office of National Drug Control Policy (Bennett, Walton, and Morris): Hearings before the Committee on the Judiciary, United States Senate, One Hundred First Congress, first session, on the nominations of Dr. William J. Bennett to be Director ..., Reggie B. Walton to be Associate Director, and Stanley E. Morris to be Deputy Director ... March 1, 2, June 6, and September 20, 1989. Washington: U.S. G.P.O., 1991.

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5

Paolo Borciani International String Quartet Competition (1st 1987 Teatro municipale Romolo Valli, Reggio Emilia, Italy). 1⁰ concorso internazionale per quartetto d'archi Paolo Borciani: 15-21 giugno 1987, Reggio Emilia, Italia, Teatro municipale Romolo Valli = 1e Internationaler Streichquartett Wettbewerb Paolo Borciani = 1st International String Quartet Competition Paolo Borciani. [Reggio Emilia: Il Concorso, 1986.

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6

Cartografica, Litografia Artistica. Reggio Emilia Provincial Road Map (1:150, 000). LAC, Italy, 2001.

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7

Cartografica, Litografia Artistica. Reggio Calabria Provincial Road Map (1:150, 000). LAC, Italy, 2001.

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8

Il Piemonte come eccezione?: Riflessioni sulla "Piedmontese exception" : atti del seminario internazionale, Reggia di Venaria, 30 novembre-1 dicembre 2007. Torino: Centro studi piemontesi, 2008.

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9

Claudio, Parmiggiani, a cura di. Sol LeWitt: Wall drawing 1126 whirls and twirls 1, Reggio Emilia : invito a Luciano Fabro, Sol LeWitt, Eliseo Mattiacci, Robert Morris, Richard Serra. Prato: Gli ori, 2004.

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10

Cultura artistica, città e architettura nell'età fridericiana: Atti del Convegno internazionale di studi, Reggia di Caserta, Cappella Palatina, 30 novembre-1 dicembre 1995. Roma: De Luca, 2000.

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Capitoli di libri sul tema "Reggie-1":

1

Martemyanov, Kirill A., Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow et al. "Reggie-1 (Reg-1)". In Encyclopedia of Signaling Molecules, 1629. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101167.

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2

Martemyanov, Kirill A., Pooja Parameswaran, Irene Aligianis, Mark Handley, Marga Gual-Soler, Tomohiko Taguchi, Jennifer L. Stow et al. "Reggie-2 (Reg-2)". In Encyclopedia of Signaling Molecules, 1629. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101168.

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3

Scheaffer, Richard L., Ann Watkins, Mrudulla Gnanadesikan e Jeffrey A. Witmer. "Waiting for Reggie Jackson: The Geometric Distribution". In Activity-Based Statistics, 79–81. New York, NY: Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4757-3843-8_17.

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4

"Reggie-1 (Reg-1)". In Encyclopedia of Signaling Molecules, 4563. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_103270.

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5

Lino, Dalila Maria, e Cristina Parente. "Play and Learning in Early Childhood Education". In Advances in Early Childhood and K-12 Education, 147–63. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5167-6.ch010.

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Abstract (sommario):

The key role of toys and play in early years education has been highlighted by several childhood pedagogues such as Froebel, Montessori, Weikart, and Malaguzzi, among many others. It is consensual among the international educational community that children now spend far more time being instructed and tested in literacy and math than they do learning through play and exploration exercising their bodies and using their imagination. This chapter aims to reflect on the power of play for children's learning and development and to analyze how three pedagogical models—the High Scope, Reggio Emilia, and Montessori—integrate play through their curriculum development. The chapter is organized in several topics, namely (1) the role of play in early childhood education (0 to 6 years); (2) the High Scope curriculum and opportunities given to children to engage in free play and play with purposes; (3) the Reggio Emilia approach: play through 100 languages; (4) the Montessori method, from hands-on activity and self-directed activity to collaborative play; (5) final remarks.

6

Taber, Douglass F. "Organic Functional Group Protection". In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0014.

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Sentaro Okamoto of Kanagawa University developed (Tetrahedron Lett. 2014, 55, 7039) an organocatalyst that mediated the selective acylation of 1 to give the primary acetate 2. Philip A. Albiniak of Ball State University devised (Tetrahedron Lett. 2014, 55, 7133) a reagent 4 for the simple preparation of a t-butyl ether 5 from an alcohol 3. Attempted deprotection of 6 tended to divert to the dioxolane. Toshio Nishikawa of Nagoya University developed (Synlett 2014, 25, 2498) an oxidative protocol that gave clean conversion to the desired 7. Alan S. Goodman of Rutgers University found (Angew. Chem. Int. Ed. 2014, 53, 10160) an Ir catalyst that generated the phenol 9 from the aryl alkyl ether 8. In the course of a synthesis of Sch 725674, Kavirayani R. Prasad of the Indian Institute of Science, Bangalore deprotected (Org. Lett. 2014, 16, 4001) the dithiane 10 to yield the sensitive aldol product 11. Karl Anker Jørgensen of Aarhus University observed (Chem. Commun. 2014, 50, 15689) that the nitro isoxazole 12, having served to activate sequential Michael addition, was readily cleaved to the acid 13. Jiang Cheng of Changzhou University used (Chem. Commun. 2014, 50, 8412) CuCN to convert 14 to 15. Pradeep Kumar of CSIR-National Chemistry Laboratory effected (Tetrahedron Lett. 2014, 55, 7172) oxidative deallylation of 16, leading to 17. Hiroyuki Morimoto and Takashi Ohshima of Kyushu University found (Chem. Commun. 2014, 50, 12623) that NH₄I promoted the hydrazinolysis of the amide 18, giving 19 without racemization. Franco Ghelfi of the Università degli Studi di Modena e Reggio Emilia prepared (Eur. J. Org. Chem. 2014, 6734) 21 by desulfonylating 20 to 21 with H₂SO₄ in acetic acid. Hans Adolfsson of Stockholm University reduced (Org. Lett. 2014, 16, 680) the amide 22 to the enamine 23. The N-vinyl amine could be hydrolyzed, but it is also a versatile intermediate for other transformations. Automated peptide synthesis can be hindered by difficult sequences. Judit Tulla-Puche and Fernando Albericio of IRB Barcelona showed (Chem. Eur. J. 2014, 20, 15031) that the substituted benzyl group of 24 facilitated such syntheses, and that it could be readily removed to give 25 by exposure to NH₄I and trifluoroacetic acid.

Atti di convegni sul tema "Reggie-1":

1

Rattighieri, Giuseppe, Michele Trancossi, Nicola Dorigo Salomon e Dean Vucinic. "Electric Vehicle Improved by Three-Phase Asynchronous Cooled Motor". In ASME 2013 7th International Conference on Energy Sustainability collocated with the ASME 2013 Heat Transfer Summer Conference and the ASME 2013 11th International Conference on Fuel Cell Science, Engineering and Technology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/es2013-18167.

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Abstract (sommario):

This paper presents the EVITA electric car. EVITA is the acronym of Electric Vehicle Improved by Three-phase Asynchronous cooled motor. It is a research project developed jointly by RGEngineering and University of Modena and Reggio Emilia. It aims to produce a novel electric power train with the capability of solving three fundamental problems of today commercial electric vehicles: 1. direct torque dependency of the rotation speed, and its reduction at high speed regimes; 2. electric motors performances reduction due to the overheating effects under heavy load conditions; 3. acclimatization of the car cabin interior in winter times.

2

Ruzzo, Carlo, Nilanjan Saha e Felice Arena. "Short-Term Extreme Motions of a Spar Floating Wind Turbine Estimated Through a 1:30 At-Sea Experiment". In ASME 2018 37th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/omae2018-78745.

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The present paper deals with the estimation of the short-term extreme motions of a spar floating wind turbine in parked rotor conditions, through a 1:30 at-sea experiment, carried out at the Natural Ocean Engineering Laboratory (NOEL) of Reggio Calabria (Italy). Thanks to some favorable local environmental conditions of the site, several wind-generated sea states with relatively low significant wave height (Hs < 0.50 m) have been collected during the experiment. These sea states are scale models of ocean storms, which are relevant hydrodynamic design conditions for the spar platform. The 30-minutes extreme values of the model structure motions have been estimated for all the six degrees of freedom, using the Weibull Tail Method (WTM), and the results obtained are presented in the paper. Such estimations are 1:30 scale models of the 3-hours extreme values of the spar motions in parked rotor conditions and may be directly used for design purposes.

3

Arena, Felice, Vincenzo Fiamma, Valentina Laface, Giovanni Malara, Alessandra Romolo, Antonino Viviano, Gianmaria Sannino e Adriana Carillo. "Installing U-OWC Devices Along Italian Coasts". In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10928.

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In the last decades, the research has directed its efforts and resources paper is to investigate towards the possibility to incorporate wave energy converters, into the traditional maritime breakwaters to combine classical use with new opportunities and developments (for example, the Green Ports). Since the nineties, the OWC (Oscillating Water Column) plants were developed at full scale to produce electrical power from ocean waves. For instance, a new plant was built in Mutriku (Spain) recently. A new kind of OWC caisson, named U-OWC or REWEC3, which has the advantage to obtain an impressive natural resonance without any device for phase control, has been patented by Boccotti [1]. This new U-OWC device gives performances better than those of a conventional OWC either with small wind waves or with high waves [2,3,4]. The properties of the REWEC3 have been verified with two small-scale field experiments carried out in the natural ocean engineering laboratory NOEL of Reggio Calabria off the eastern coast of the Sicily Channel [5–7]. The aim of the present two sites along Italian coasts for possible installations of REWEC3 devices: i) the port of Civitavecchia (Rome, Italy)in the Tyrrhenian sea; ii) the port of Pantelleria, in the Sicily Channel.

4

Camporeale, Sergio M., e Pasquale G. F. Filianoti. "Energy Conversion OWC Devices With Additional Vertical Ducts". In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-57769.

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Abstract (sommario):

In breakwaters embodying an OWC connected to the sea through a vertical duct or through a small opening, the oscillations of the water column are due to the wave pressure acting on the outer opening of the vertical duct or on the small opening. In fact, in neither of the two cases waves can enter the plant, like it happens in conventional OWCs. The additional vertical duct extends along the wave-beaten wall, giving the device the characteristic form of a U-conduit; for this reason they were also named U-OWC. Experiments on a small-scale breakwater embodying a U-OWC were carried out in the natural laboratory of Reggio Calabria. The plant is a 1:10 scale model of a breakwater suitable for the North-East Pacific coast. The paper describes new experiments on the U-OWC device connected to a monoplane Wells turbine. During an intensive measurement campaign, more than 260 sea states, 5 min long were recorded in order to characterize the energy conversion process. From the experiments, the analysis of the energy conversion shows that: 1) the system is able to absorb a share up 80% of the incident wave energy; this result is similar to that obtained in previous experiments carried out without the turbine; 2) a large fraction of the energy entering the U-OWC is converted in pneumatic power acting on the turbine, being head losses in the water flow limited; 3) the efficiency of conversion of the pneumatic power in turbine power is relatively low (about 36% of the pneumatic power) due to the small dimensions of the turbine that lead to low Reynolds number and large influence of secondary losses.