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Tesi sul tema "Regulatory T cell"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 25 luglio 2025

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1

Carson, Bryan David. "Impaired T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8337.

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2

Stefkova, Martina. "Regulatory T cells control the CD4 T cell repertoire." Doctoral thesis, Universite Libre de Bruxelles, 2016. https://dipot.ulb.ac.be/dspace/bitstream/2013/233151/3/Table.pdf.

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Abstract (sommario):
Des études récentes menées chez l’homme et la souris ont suggéré que la diversité du répertoire TCR pourrait jouer un rôle dans la protection contre des pathogènes à haut pouvoir mutagène. Afin d’étudier le répertoire des lymphocytes T CD4, nous avons utilisé un modèle de souris TCRβ transgéniques exprimant une chaine β spécifique du peptide env122-141 dans le contexte du MHCII. Suite à l’immunisation des souris TCRβ transgéniques avec des cellules dendritiques pulsées avec le peptide env, une rapide prolifération et une restriction du répertoire des lymphocytes T Vα2 CD4 spécifiques est obser
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3

Sarris, Milka. "Dynamics of helper T cell and regulatory T cell interactions with dendritic cells." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611896.

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4

Nadal-Melsio, Elisabet. "Regulatory T cells after allogeneic stem cell transplantation." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.523746.

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5

Mavin, Emily. "Regulatory T cells in haematopoietic stem cell transplantation." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2731.

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Abstract (sommario):
Graft-versus-host disease (GvHD) remains the main complication associated with haematopoietic stem cell transplantation (HSCT). GvHD is caused by allo-reactive donor T cells mounting an attack against specific target tissues. CD4+CD25HiFoxp3+ regulatory T cells have been shown to modulate GvHD in vitro and also in vivo animal models. More recently early stage clinical trials have described the successful use of Treg to reduce the incidence of GvHD following HSCT. The aim of this study was to investigate further the suppressive mechanisms by which Treg are able to modulate GvHD and assess the i
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6

Raynor, Jana L. "Regulatory T Cell Homeostasis in Aging." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570329.

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7

Smith, Trevor Robert Frank. "Modulation of CD4+ T cell responses by CD4+CD25+ regulatory T cells and modified T cell epitopes." Thesis, Imperial College London, 2004. http://hdl.handle.net/10044/1/11317.

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8

Soper, David Michael. "Interleukin-2 receptor and T cell receptor signaling in regulatory T cells /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8344.

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9

Cabbage, Sarah E. "Reversible regulatory T cell-mediated suppression of myelin basic protein-specific T cells /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5034.

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10

Vanderleyden, Ine. "Follicular regulatory T cell migration and differentiation." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/288422.

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Abstract (sommario):
The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the mechanism/s through which they exert their suppressive function. At the outset of this work, the major barrier to un
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11

Wright, G. P. "Generation of antigen-specific regulatory T cells by T cell receptor gene transfer." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18952/.

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Abstract (sommario):
Regulatory T cells (Tregs) have shown considerable potential in the treatment of murine models of immuno-pathology. Whilst poly-clonal Tregs are able to suppress immuno-pathology in a number of models, the superiority of Ag-specific Treg treatment has been demonstrated using Tregs from T cell receptor (TCR)- transgenic animals. Translation of these promising results to the clinic has been hampered by difficulties in isolating or enriching the rare Ag-specific Tregs from the polyclonal population. Here I describe two distinct approaches to generate Ag-specific T cells with regulatory ability: f
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12

Paiva, Ricardo de Sousa. "T cell Maturation and Regulatory T Cell Differentiation:From the Thymus to the Periphery." Doctoral thesis, Universidade Nova de Lisboa.Instituto de Tecnologia Química e Biológica, 2012. http://hdl.handle.net/10362/10587.

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Abstract (sommario):
Immunological tolerance, that is, the failure to mount an immune response to an otherwise immunogenic molecule, is one of the fundamental questions in immunology. The fact that lymphocytes express antigen receptors that are generated randomly and have the potential to recognize any conceivable antigen, adds another puzzle to the physiology of immunological tolerance. The other side of the coin, the general absence of immune responses to self antigens, is ensured by a tight regulation and several selection steps during T and B cell differentiation. One of these processes is the different
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13

Lindqvist, Camilla. "T Regulatory Cells – Friends or Foes?" Doctoral thesis, Uppsala universitet, Enheten för klinisk immunologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128837.

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Abstract (sommario):
T regulatory cells (Tregs) have been extensively studied in patients with cancer or autoimmunity. These cells hamper the immune system’s ability to clear tumor cells in cancer patients. In autoimmune diseases, on the other hand, they are not able to restrain autoreactive immune responses. If we manage to understand Tregs and their role in health and diseases we may be able to develop better immunomodulatory therapies. Early studies demonstrated that tolerance was maintained by a subset of CD25+ T-cells. CD25 was the earliest marker for Tregs and is still often used to define these cells. Sever
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14

Sather, Blythe Duke. "CD4+ Foxp3+ regulatory T cell homing & homeostasis /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8343.

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15

Warth, Sebastian. "A microRNA network in regulatory T cell differentiation." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-185611.

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16

Kolodin, Dmitriy Pavlovich. "Dynamics of Tissue-Resident Regulatory T Cell Populations." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11555.

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Abstract (sommario):
In recent years, there has been a worldwide increase in obesity, which parallels a rise in pathologies, including type 2 diabetes, collectively termed the metabolic syndrome. Chronic, low-grade inflammation has been implicated as a major link between these diseases. Recent work showed the presence of a unique subset of CD4+Foxp3+ regulatory T cells residing in visceral adipose tissue (VAT Treg) with PPAR-g being the key transcription factor responsible for their phenotype and function in controlling adipose tissue inflammation and, thereby, insulin sensitivity. VAT Tregs inversely correlated w
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17

Himmel, Megan Elizabeth. "Phenotypic and functional characterization of T cells and Foxp3⁺ T regulatory cells in inflammatory bowel disease : steps towards T regulatory cell therapy in mucosal disease." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42517.

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Abstract (sommario):
Because of their potent suppressive capacity and critical role in the normal function of the human immune system, T regulatory cells (Tregs) have long been considered candidates for the therapeutic treatment of autoimmune and chronic inflammatory diseases. However, the clinical implementation of these cells has proven challenging in practice, in part due to a lack of knowledge surrounding this T cell subset. Specifically, an evaluation of the unique functions of individual Treg cell lineages, along with a comprehensive investigation of the non-suppressive capacities of these cells, including c
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18

Sandalova, Elena. "Regulation of the pro-apoptotic protein bim by T cell receptor triggering in human T cells /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-041-1/.

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19

Terry, Alexandra Margaret. "The Roles of CD4+ T cells and Regulatory T cells in Antitumour Immunity." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/17331.

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Although the immune system is rapidly becoming a key target for cancer treatment we still lack a comprehensive understanding of how the immune system affects cancer progression. Animal models, such as the one used in this thesis, help to delineate the complex feedback interactions between the immune system and cancer and to identify novel cellular and molecular targets for anticancer drugs. The negative role of regulatory T cells (Tregs) in cancer is well but their mechanism and cellular targets are not fully understood. This thesis uses a novel transgenic mouse model to establish how tumour-
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20

Varikuti, Sanjay. "Role of CD4+CD25+ Regulatory T Lymphocytes in Experimental Toxoplasmosis." TopSCHOLAR®, 2009. http://digitalcommons.wku.edu/theses/113.

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Abstract (sommario):
Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with Toxoplasma gondii. T regulatory (Treg) cells have been shown to play an
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21

Nissen, Jesper Klintø. "Control of regulatory T cell lineage differentiation by Foxp3." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609792.

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22

Salisbury, Emma. "Forward genetic analysis of natural T regulatory cell development." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/18844.

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Abstract (sommario):
Natural (n) T regulatory (Treg) cells generated in the thymus are essential throughout life for the maintenance of T cell homeostasis and prevention of autoimmunity. T cell receptor (TCR)/CD28-mediated activation of Nuclear Factor Kappa-light-chain-enhancer of activated B cells (NFB) and Jun N-terminal kinase (JNK) pathways is known to play a key role in nTreg development but many of the predicted molecular interactions are based on extrapolations from non-Treg cell TCR stimulation with non-physiological ligands. For the first time, this work provides strong genetic evidence of a scaffold fun
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23

Cook, Katherine. "The Regulatory T-cell response to Helicobacter pylori infection." Thesis, University of Nottingham, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664309.

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Abstract (sommario):
Helicobacter pylori is a Gram-negative bacterium that infects the human stomach and can cause peptic ulcer disease CPUD) and gastric adenocarcinoma. Around 50% of the world's population is infected with H. pylori, but only about 10-15% of infected people go on to develop clinical symptoms, with around 1 % developing gastric cancer. There is evidence that H. pylori may also provide protection against some disease including gastric reflux and more controversially extra-gastric conditions such as asthma and allergy. The anti-inflammatory regulatory T-cell (Treg) response is increased during H. py
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24

Huynh, Alexandria. "Mechanisms of regulatory T cell lineage homeostasis and stability." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467375.

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Abstract (sommario):
Defined by the transcription factor Foxp3, regulatory T cells (Tregs) are a lineage of CD4+ T lymphocytes critical for the maintenance of immune homeostasis and tolerance. A lack of functional Tregs in both mice and humans leads to a fatal systemic autoimmune disease, underscoring their importance as mediators of tolerance to self antigen. One notable distinction between conventional T cells (Tconv) and Tregs is their differential control of the phosphatidylinositol 3-kinase (PI3K) pathway: PTEN, the primary negative regulator of PI3K, is expressed at high levels constitutively in Tregs, preve
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25

Meredith, Tobias. "The regulatory effects of CD161 and MAIT cells." Thesis, Federation University Australia, 2020. http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/176644.

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Abstract (sommario):
Mucosal associated invariant T (MAIT) cells are connected with the potential regulation of anti-tumour responses, although their role in this regulation is poorly defined. In cancer, the relative frequency of MAIT cells has an impact on patient outcome, although how this impact is mediated is not known. Therefore, we have carefully modulated the frequency of MAIT cells within cultures and assessed the effect this has on the anti-tumour functions of important immune cells such as NK and conventional T cells. We identified that changes in MAIT cell frequency can significantly impact the ability
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26

Danby, Robert David. "A study of regulatory T cells in allogeneic haematopoietic stem cell transplantation." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:341878ee-8c3e-4eef-ab16-b1b04e34bf4d.

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Abstract (sommario):
Allogeneic haematopoietic stem cell transplantation (alloHSCT) is an established therapy for many haematological disorders. Unfortunately, the new donor-derived immune system may damage host cells (graft-versus-host disease (GvHD)), causing significant morbidity and mortality. Since regulatory T cells (Tregs) can modulate immune responses, it was hypothesised that Treg numbers in the haematopoietic stem cell grafts and/or peripheral blood may influence the development of GvHD and other transplant-related complications. In this project, a prospective observational clinical study of putative Tre
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27

Huang, Anfei [Verfasser]. "Progranulin Prevents Regulatory NK Cell Cytotoxicity Against Antiviral T Cells / Anfei Huang." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/123423341X/34.

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28

Berglund, David. "Preparatory Studies to Introduce Regulatory T Cells in Clinical Transplantation." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-220873.

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Abstract (sommario):
Solid organ transplantation has evolved from being an experimental procedure to a life-saving treatment for patients with end-stage organ failure. The risk of losing a transplant due to acute rejection is very low with the use of modern immunosuppressive protocols and the short-term results are impressive. However, long-term outcomes are suboptimal and transplant recipients are at increased risks for severe complications such as cancers, opportunistic infections and cardiovascular events. The previous struggle to achieve short-term survival has turned into a search for new strategies to improv
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29

Uttenthal, B. J. "T cell receptor-transduced regulatory T cells : functional studies in models of graft-versus-host disease." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1379030/.

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Abstract (sommario):
Alloreactive immune responses directed against malignant cells in recipients of allogeneic haematopoietic stem cell transplants are able to cure patients with haematological cancers. However, such immune responses may cause severe morbidity when directed against healthy recipient tissue, resulting in graft-versus-host disease (GvHD). Naturally occurring regulatory T cells (Tregs) are CD4+ T cells characterized by their expression of the transcription factor Foxp3. Whilst adoptively transferred polyclonal Tregs suppress GvHD in several murine models, their lack of specificity may compromise ben
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30

Jain, Nitya. "Multifaceted Regulation of Peripheral T Cell Tolerance and Autoimmunity by FOXP3+ T Regulatory Cells: A Dissertation." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/416.

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Abstract (sommario):
Adaptive immunity requires T cell responses to foreign pathogens to be counterbalanced with the need to limit collateral destruction of the host’s own tissues. Further, the presence of a substantial pool of lymphocytes capable of recognizing selfantigen in the periphery poses a threat to the maintenance of peripheral tolerance and prevention of autoimmunity. Regulatory T cells (Treg) that can suppress potentially self-reactive T cells are critical regulators of peripheral tolerance as well as initiation of immune responses. Treg cells employ several context-dependent mechanisms to establish re
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31

Lei, Hong. "Human natural regulatory T cells subsets." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16958.

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Abstract (sommario):
Regulatorische T-Zellen (Treg) eröffnen neue immuntherapeutische Wege zur Kontrolle unerwünschter Immunreaktionen, jedoch wirft die Heterogenität dieser Zellen die Frage auf, welche Treg-Population für die klinische Anwendung. Darauf basierend werden in dieser Arbeit drei Fragestellungen bearbeitet: i) Bestimmung der Häufigkeit von Tregs und deren Subpopulationen in verschiedenen Altersgruppen bei Empfängern einer Organtransplantation (Tx) und einer gesunden Kontrollgruppe; ii) Vergleich der Suppressorkapazität verschiedener Treg-Populationen und in vitro-Expansion der Zellen unter Erhaltung i
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32

Chen, Ye. "Induced regulatory T cells in transplantation tolerance." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:cffc275b-d32c-495e-a1da-55421a57e7e7.

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Abstract (sommario):
Induced regulatory T cells (iTreg) play an important role in the induction of tolerance to self and non-self antigens. Harnessing their suppressive potential has therapeutic implications for the treatment of autoimmune conditions and transplant rejection. Although the role of TGFβ-conditioned iTreg in natural and therapeutic tolerance is indisputable, their mechanism of action as well as factors that influence their function and stability in vivo remain unclear. Here it is shown that TGFβ-conditioning of T cells in the absence of any Foxp3 expression is insufficient for conferring a
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33

Marshall, D. J. "The role of multiple cell types in the development of regulatory T-cells." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1417081/.

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Abstract (sommario):
FoxP3 expressing regulatory T-cells (Treg) are essential for preventing autoimmunity by the immune system. The dynamics and signalling requirements for Treg development in the thymus are not well understood but are thought to integrate TCR, co-stimulatory and cytokine signalling. Previous studies have been hampered by the difficulty of distinguishing peripheral homeostasis from de novo thymic generation of Treg. To circumvent this problem, we used mice bearing both a FoxP3 reporter allele (FoxP3GFP) and in which Zap70 expression is controlled by a Tet-inducible transgene (TetZap70), induced by
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34

Heil, Luke. "THE ROLE OF CD8 T CELL IMMUNODOMINANCE AND REGULATORY T CELLS IN NEONATAL IMMUNITY TO INFLUENZA VIRUS." UKnowledge, 2019. https://uknowledge.uky.edu/microbio_etds/22.

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Abstract (sommario):
Neonates are more susceptible to influenza virus infection than adults, resulting in increased morbidity and mortality as well as delayed clearance of the virus. Efforts to improve influenza infection outcomes in neonates typically center on prevention, although current vaccines fall short of complete protection and can only be administered in humans after 6 months of life. We propose that as the neonatal immune system responds differently than the adult immune system, interventions that are efficacious or tolerable in adults cannot be guaranteed to perform the same in neonates. T cell vaccine
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35

George, Mariam M. B. S. "Zinc regulates tolerogenic dendritic cell phenotype and skews regulatory T cell- Th17 balance." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439305564.

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36

Burocchi, Alessia. "Modulation of regulatory T cell suppression in tumors through OX40." Thesis, Open University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576669.

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Abstract (sommario):
Tumor cells develop numerous mechanisms to escape from the control exerted by the immune system. One of these strategies is the accumulation of regulatory T cells (Treg) within the tumor, which keep effector T cells (Teff) and dendritic cells (DC) in an inactive state. An efficient approach to overcome the inhibitory potential of Treg focuses on OX40, a costimulatory molecule constitutively expressed by Treg and induced in activated Teff. The treatment of mouse transplantable tumor models with the mAb OX86, the agonist of OX40, induces tumor rejection by acting on both these T cell subsets. In
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37

Sharif-Paghaleh, Ehsan. "In vivo imaging of regulatory T cell mediated transplant tolerance." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/in-vivo-imaging-of-regulatory-t-cell-mediated-transplant-tolerance(4ee28e3c-431f-430f-9484-d22f030787b1).html.

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Abstract (sommario):
Regulatory T cells (Tregs) were identified several years ago and are key in controlling autoimmune diseases and limiting immune responses to foreign antigens. These cells have been used successfully in animal models first and more recently in the clinic to prevent Graft vs Host disease and transplant rejections. However, their locations in vivo, their migratory abilities and their in vivo survival have not been extensively investigated. Imaging of the human sodium/iodide symporter via Single Photon Emission Computed Tomography (SPECT) has been used as a reporter gene to image various cell type
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38

Mair, Iris. "Investigating mechanisms of regulatory T cell function in inflammatory disease." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28705.

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Abstract (sommario):
Regulatory T cells (Treg) play a crucial role in controlling immune homeostasis. Several inflammatory diseases including multiple sclerosis and inflammatory bowel disease have been associated with dysfunctional and/or reduced numbers of Treg. While several mechanisms of action have been discovered by which Treg can exert their function, disease-specific Treg requirements remain unknown. The Treg pool consists of highly diverse subpopulations, indicating that there is a potential to optimise Treg-targeted therapies if disease-relevant mechanisms can be established. Microarray data from our lab
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39

Franchini, Fanny. "Immune regulatory networks in inflammation-driven cancer." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:2314081e-8c3f-43c7-9ea6-edf43430a43c.

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Abstract (sommario):
The incidence of colorectal cancer (CRC) is increasing and the prognosis for patients with advanced or metastatic disease is relatively poor. Immunotherapies hold great promise, but deploying them effectively in CRC patients will require further knowledge of the complex cellular and molecular interactions that occur between intestinal tumours and the host immune system. The objective of this study is to understand the mechanisms by which lack of immune cell regulation in the gut can drive the formation of colon adenocarcinomas. In addition, this work aims to identify new mechanisms involved in
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40

Schreiber, Taylor Houghton. "Balancing Effector and Regulatory T Cell Responses in Cancer and Autoimmunity." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/654.

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Abstract (sommario):
Activation of immunity to self-antigens is the goal in cancer immunotherapy, whereas blocking such responses is the goal in autoimmune disease. Thus, it is not surprising that investigation into cancer immunotherapy might also produce insights for the treatment of autoimmune disease. Heat shock protein, gp96, based therapies lead to the robust activation of CD8+ cytotoxic T cells that can slow tumor growth in 60-70% of mice, but only lead to the elimination of tumors in 30-40% of animals. The primary goal of the current studies was to understand why vaccination with a secreted gp96 vaccine wa
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41

Chan, Ping-lung, and 陳秉隆. "Roles of TLR5 and ICOS on the human allogenic CD40-activated B cell-induced CD4hiCD25+ regulatory T cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47149735.

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42

Carretero-Iglesia, Laura. "Autologous regulatory myeloid cell therapy in transplantation." Nantes, 2014. http://archive.bu.univ-nantes.fr/pollux/show.action?id=57eee07a-2290-4c76-b10e-0603a68039b7.

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Abstract (sommario):
The aim in organ transplantation is to induce specific long-term allograft tolerance. Current therapies control short-term allograft rejection but are inefficient against late graft failure. Moreover, they carry important side-effects, rendering patients vulnerable to other diseases. New therapies are nowadays being developed. The use of in vitro modified cell types as a strategy to induce donor-specific tolerance has proven to be effective to prolong allograft survival in a variety of animal models. Myeloid cells play a key role in transplantation. They are involved in both, tolerance and rej
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43

Hoffmann, Markus [Verfasser]. "Regulatory T cell-mediated suppression of Th9 cell development and effector function / Markus Hoffmann." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/104816490X/34.

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44

Oldham, Kimberley Anne. "The recruitment and role of effector and regulatory T cells in renal cell carcinoma." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3263/.

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Abstract (sommario):
Immunotherapy for renal cell carcinoma (RCC) has yielded some clinical responses. However this approach frequently fails, possibly due to inefficient migration of T-cells to tumour tissue or immunosuppressive mechanisms within the tumour environment. To aid development of T-cell therapy for RCC I investigated how T-cells are recruited to this tumour, which T-cell subsets infiltrate, and how they function. Analysis of the expression of all 19 chemokine receptors on matched TIL and PBMC demonstrated that CCR5, CXCR3 and CXCR6 were expressed at significantly higher levels on tumour-infiltrating T
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45

Hirani, S. "The characterisation of human umbilical cord blood regulatory T cell subsets." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344048/.

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Abstract (sommario):
Umbilical cord blood (CB) is recognised to be a valuable alternative to bone marrow (BM) as a source of hematopoietic stem cells (HSC). The occurrence of Graft vs. Host Disease (GvHD) after CB transplantation has been reported to be less severe in comparison to BM transplants. In addition to the naive state of immune cells, the action of immuno-suppressive cells such as regulatory T cells (Treg) may contribute to the positive aspects observed in CB transplants. This study investigated the phenotypic and functional characteristics of CB Treg and their potential for expansion in culture. In addi
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46

Walter, Gina. "Do activated monocytes impair regulatory T cell function in rheumatoid arthritis?" Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/do-activated-monocytes-impair-regulatory-t-cell-function-in-rheumatoid-arthritis(bec96e89-858a-42a3-87cf-6167ee9d633e).html.

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Abstract (sommario):
Rheumatoid arthritis (RA) is a chronic inflammatory immune disease affecting the joints. CD4+CD25+ regulatory T cells (Tregs) are abundantly present in the inflamed joints of patients with RA, but inflammation still persists. The notion that Tregs are terminally differentiated suppressor cells has recently been disputed by studies showing that Tregs can display a significant degree of plasticity and even convert into IL-17-producing cells under inflammatory conditions. Therefore, the overall hypothesis of this thesis was that the pro-inflammatory environment impairs Treg function in RA by conv
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47

Whatcott, Andrew. "Assessing the impact of immunosuppressive drugs on regulatory T cell therapy." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:d3e538bc-0558-4f12-8be4-5f77d79c4323.

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Abstract (sommario):
Immunosuppressive drugs have facilitated the progression of solid organ transplantation from experimental therapy to routine practice, however transplant recipients are still susceptible to chronic rejection and co-morbidities. The emergence of regulatory T cells (Treg) as a key regulator of the immune system, together with an abundance of evidence from experimental transplant models, has led to clinical trials asking whether Treg can improve transplant outcomes. However, given that Treg cellular therapy will only be acceptable if introduced into current immunosuppressive regimens, a critical
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48

Powell, Michael D. "Insights Into the Regulatory Requirements for T Follicular Helper Cell Development." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89085.

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Abstract (sommario):
During the course of an immune response, CD4+ T helper cells differentiate into a number of subsets including: T helper 1 (TH1), TH2, TH17, and T follicular helper (TFH) populations. The functional diversity of CD4+ T effector cells results in a coordinated, pathogen-specific immune response. For example, the production of IFNγ by TH1 cells is vital for the clearance of intracellular pathogens, while TFH cell engagement with cognate B cells is required for germinal center (GC) formation and the generation of pathogen- and vaccine- induced antibody production. The development of CD4+ subsets
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49

Hu, Mingjing. "Human regulatory T cell physiology - Lessons learnt from newborns and adults." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18396.

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Abstract (sommario):
Human Regulatory T (Treg) cells play a critical role in the immune homeostasis. Hence, understanding Treg cell physiology is of vital importance. Various soluble factors, including IL-10 and short chain fatty acids (SCFAs), contribute to the transplacental immune programming by shaping the fetal immune system, specifically Treg cells. Therefore, this thesis aims to provide further evidence for the Treg cell transplacental programming, and to explain how SCFAs contribute to this process. We demonstrated that the absence of maternal gut microbiota caused significantly reduced fetal thymus size a
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50

Strainic, Michael George Jr. "THE ABSENCE OF C3AR AND C5AR SIGNAL TRANSDUCTION PROMOTES T REGULATORY CELL DIFFERENTIATION AND REGULATES IMMUNOLOGIC TOLERANCE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1363707372.

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