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Articoli di riviste sul tema "Regulatory T cell"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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1

ZHOU, Zhou, Juan FENG, and Xian WANG. "Regulatory T Cell Differentiation and Regulators." ACTA BIOPHYSICA SINICA 28, no. 2 (2012): 93. http://dx.doi.org/10.3724/sp.j.1260.2012.20002.

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2

Ait-Oufella, Hafid, and Alain Tedgui. "Regulatory T-Cell Plasticity." Circulation Research 118, no. 10 (2016): 1461–63. http://dx.doi.org/10.1161/circresaha.116.308805.

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3

Bashyam, Hema. "Regulatory T cell brakes." Journal of Experimental Medicine 205, no. 3 (2008): 505. http://dx.doi.org/10.1084/jem.2053iti1.

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4

Savage, Peter A., David E. J. Klawon, and Christine H. Miller. "Regulatory T Cell Development." Annual Review of Immunology 38, no. 1 (2020): 421–53. http://dx.doi.org/10.1146/annurev-immunol-100219-020937.

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Abstract (sommario):

Foxp3-expressing CD4+ regulatory T (Treg) cells play key roles in the prevention of autoimmunity and the maintenance of immune homeostasis and represent a major barrier to the induction of robust antitumor immune responses. Thus, a clear understanding of the mechanisms coordinating Treg cell differentiation is crucial for understanding numerous facets of health and disease and for developing approaches to modulate Treg cells for clinical benefit. Here, we discuss current knowledge of the signals that coordinate Treg cell development, the antigen-presenting cell types that direct Treg cell sele

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5

Rosenblum, Michael D., Sing Sing Way, and Abul K. Abbas. "Regulatory T cell memory." Nature Reviews Immunology 16, no. 2 (2015): 90–101. http://dx.doi.org/10.1038/nri.2015.1.

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6

Ward-Hartstonge, Kirsten A., and Ajithkumar Vasanthakumar. "Regulatory T-cell heterogeneity." Clinical & Translational Immunology 7, no. 3 (2018): e01012. http://dx.doi.org/10.1002/cti2.1012.

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7

Mohammadnia-Afrouzi, Mousa, Mehdi Shahbazi, Sedigheh Baleghi Damavandi, Ghasem Faghanzadeh Ganji, and Soheil Ebrahimpour. "Regulatory T-cell: Regulator of Host Defense in Infection." Journal of Molecular Biology Research 7, no. 1 (2017): 9. http://dx.doi.org/10.5539/jmbr.v7n1p9.

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Abstract (sommario):

Based on diverse activities and production of several cytokines, T lymphocytes and T helper cells are divided into Th1, Th2, Th17 and regulatory T-cell (T regs) subsets based on diverse activities and production of several cytokines. Infectious agents can escape from host by modulation of immune responses as effector T-cells and Tregs. Thus, regulatory T-cells play a critical role in suppression of immune responses to infectious agents such as viruses, bacteria, parasites and fungi and as well as preserving immune homeostasis. However, regulatory T-cell responses can advantageous for the body

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8

Bruneau, Julie, Danielle Canioni, Amédée Renand, et al. "Regulatory T-Cell Depletion in Angioimmunoblastic T-Cell Lymphoma." American Journal of Pathology 177, no. 2 (2010): 570–74. http://dx.doi.org/10.2353/ajpath.2010.100150.

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9

Moltedo, Bruno, Saskia Hemmers, and Alexander Y. Rudensky. "Regulatory T Cell Ablation Causes Acute T Cell Lymphopenia." PLoS ONE 9, no. 1 (2014): e86762. http://dx.doi.org/10.1371/journal.pone.0086762.

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10

Young, M., and R. S. Geha. "Human Regulatory T-Cell Subsets." Annual Review of Medicine 37, no. 1 (1986): 165–72. http://dx.doi.org/10.1146/annurev.me.37.020186.001121.

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11

Papatriantafyllou, Maria. "Distilling regulatory T cell inducers." Nature Reviews Immunology 13, no. 8 (2013): 547. http://dx.doi.org/10.1038/nri3506.

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12

Shevach, Ethan M. "Special regulatory T cell review: How I became a T suppressor/ regulatory cell maven." Immunology 123, no. 1 (2008): 3–5. http://dx.doi.org/10.1111/j.1365-2567.2007.02777.x.

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13

Scott, David W. "T regulatory cells turn on T regulatory cells." Blood 114, no. 19 (2009): 3975–76. http://dx.doi.org/10.1182/blood-2009-09-241406.

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14

Lechler, Robert, Jian-Guo Chai, Federica Marelli-Berg, and Giovanna Lombardi. "T–cell anergy and peripheral T–cell tolerance." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1409 (2001): 625–37. http://dx.doi.org/10.1098/rstb.2001.0844.

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Abstract (sommario):

The discovery that T–cell recognition of antigen can have distinct outcomes has advanced understanding of peripheral T–cell tolerance, and opened up new possibilities in immunotherapy. Anergy is one such outcome, and results from partial T–cell activation. This can arise either due to subtle alteration of the antigen, leading to a lower–affinity cognate interaction, or due to a lack of adequate co–stimulation. The signalling defects in anergic T cells are partially defined, and suggest that T–cell receptor (TCR) proximal, as well as downstream defects negatively regulate the anergic T cell's a

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15

Beltran, Brady E., Domingo Morales, Pilar Quinones, Roberto N. Miranda, Maitrayee Goswami, and Jorge J. Castillo. "Peripheral T-cell Lymphoma With a Regulatory T-cell Phenotype." Applied Immunohistochemistry & Molecular Morphology 20, no. 2 (2012): 196–200. http://dx.doi.org/10.1097/pai.0b013e318225189f.

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16

Basten, Antony, and Barbara Fazekas de St Groth. "Special regulatory T-cell review: T-cell dependent suppression revisited." Immunology 123, no. 1 (2008): 33–39. http://dx.doi.org/10.1111/j.1365-2567.2007.02772.x.

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17

Ninchoji, Takeshi, Hiroshi Kaito, and Kazumoto Iijima. "Regulatory T Cell and Nephrotic Syndrome." Nihon Shoni Jinzobyo Gakkai Zasshi 25, no. 2 (2012): 137–41. http://dx.doi.org/10.3165/jjpn.25.137.

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18

Baardman, Jeroen, and Esther Lutgens. "Regulatory T Cell Metabolism in Atherosclerosis." Metabolites 10, no. 7 (2020): 279. http://dx.doi.org/10.3390/metabo10070279.

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Abstract (sommario):

Regulatory T cells (Tregs) are capable of suppressing excessive immune responses to prevent autoimmunity and chronic inflammation. Decreased numbers of Tregs and impaired suppressive function are associated with the progression of atherosclerosis, a chronic inflammatory disease of the arterial wall and the leading cause of cardiovascular disease. Therefore, therapeutic strategies to improve Treg number or function could be beneficial to preventing atherosclerotic disease development. A growing body of evidence shows that intracellular metabolism of Tregs is a key regulator of their proliferati

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19

Barchet, Winfried, Jeffrey D. Price, Marina Cella, et al. "Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation." Blood 107, no. 4 (2006): 1497–504. http://dx.doi.org/10.1182/blood-2005-07-2951.

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Concurrent activation of the T-cell receptor (TCR) and complement regulator CD46 on human CD4+ T lymphocytes induces Tr1-like regulatory T cells that suppress through IL-10 secretion bystander T-cell proliferation. Here we show that, despite their IL-10 production, CD46-induced T-regulatory T cells (Tregs) do not suppress the activation/maturation of dendritic cells (DCs). DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion of GM-CSF and soluble CD40L, factors favoring DC differentiation and reversing inhibitory effects of IL-10. Thus, CD46-induced Tregs p

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20

Kupiec-Weglinski, Jerzy W. "OX40 costimulation and regulatory T cells." Blood 110, no. 7 (2007): 2217–18. http://dx.doi.org/10.1182/blood-2007-07-097642.

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21

Vlasova, V. V., та N. G. Shmagel. "PGC-1α in human CD4+T cell subsets". Russian Journal of Immunology 23, № 2 (2020): 115–18. http://dx.doi.org/10.46235/1028-7221-348-pih.

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CD4+T lymphocyte pool is heterogeneous in nature consisting of distinct subsets. The functional activity of each subset is highly influenced by how its energy metabolism is controlled. In naïve, central memory, effector memory, and TEMRA CD4+T cells received from healthy volunteers aged 29-42 years we evaluated the level of the major cell energy metabolism regulator: transcriptional coactivator PGC-1α. PGC-1α was shown to be expressed in all CD4+T cells. Its level in central memory, effector memory, and TEMRA cells was higher than that in naïve cells for both conventional and regulatory CD4+T

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22

Sawasdikosol, Sansana, Renyuan Zha, Timothy S. Fisher, Saba Alzabin, and Steven J. Burakoff. "HPK1 Influences Regulatory T Cell Functions." ImmunoHorizons 4, no. 7 (2020): 382–91. http://dx.doi.org/10.4049/immunohorizons.1900053.

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23

TANAKA, Satoshi, and Shimon SAKAGUCHI. "Regulatory T cell and autoimmune diseases." Japanese Journal of Clinical Immunology 28, no. 5 (2005): 291–99. http://dx.doi.org/10.2177/jsci.28.291.

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24

Jiang, Shuiping, Robert I. Lechler, and Giovanna Lombardi. "CD4+CD25+regulatory T-cell therapy." Expert Review of Clinical Immunology 2, no. 3 (2006): 387–92. http://dx.doi.org/10.1586/1744666x.2.3.387.

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25

CATON, ANDREW J., CRISTINA COZZO, JOSEPH LARKIN, MELISSA A. LERMAN, ALINA BOESTEANU, and MARTHA S. JORDAN. "CD4+CD25+Regulatory T Cell Selection." Annals of the New York Academy of Sciences 1029, no. 1 (2004): 101–14. http://dx.doi.org/10.1196/annals.1309.028.

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26

Tang, Qizhi, and Karim Lee. "Regulatory T-cell therapy for transplantation." Current Opinion in Organ Transplantation 17, no. 4 (2012): 349–54. http://dx.doi.org/10.1097/mot.0b013e328355a992.

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27

MacDonald, Katherine G., Paul C. Orban, and Megan K. Levings. "T regulatory cell therapy in transplantation." Current Opinion in Organ Transplantation 17, no. 4 (2012): 343–48. http://dx.doi.org/10.1097/mot.0b013e328355aaaf.

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28

Singer, Benjamin D. "Opening the Regulatory T Cell Toolbox." American Journal of Respiratory Cell and Molecular Biology 57, no. 2 (2017): 137–38. http://dx.doi.org/10.1165/rcmb.2017-0130ed.

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29

Konopacki, Catherine, George Plitas, and Alexander Rudensky. "Reigning in regulatory T-cell function." Nature Biotechnology 33, no. 7 (2015): 718–19. http://dx.doi.org/10.1038/nbt.3285.

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30

BODAGHI, B. "Regulatory T cell therapy for uveitis." Acta Ophthalmologica 90 (August 6, 2012): 0. http://dx.doi.org/10.1111/j.1755-3768.2012.3643.x.

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31

Wei, Shuang, Ilona Kryczek, and Weiping Zou. "Regulatory T-cell compartmentalization and trafficking." Blood 108, no. 2 (2006): 426–31. http://dx.doi.org/10.1182/blood-2006-01-0177.

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Abstract (sommario):

CD4+CD25+FOXP3+ regulatory T cells (CD4+ Treg cells) are thought to differentiate in the thymus and immigrate from the thymus to the periphery. Treg cells can regulate both acquired and innate immunity through multiple modes of suppression. The cross-talk between Treg cells and targeted cells, such as antigen-presenting cells (APCs) and T cells, is crucial for ensuring suppression by Treg cells in the appropriate microenvironment. Emerging evidence suggests that Treg compartmentalization and trafficking may be tissue or/and organ specific and that distinct chemokine receptor and integrin expre

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32

Mallat, Ziad, Hafid Ait-Oufella, and Alain Tedgui. "Regulatory T-Cell Immunity in Atherosclerosis." Trends in Cardiovascular Medicine 17, no. 4 (2007): 113–18. http://dx.doi.org/10.1016/j.tcm.2007.03.001.

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33

Buszko, Maja, and Ethan M. Shevach. "Control of regulatory T cell homeostasis." Current Opinion in Immunology 67 (December 2020): 18–26. http://dx.doi.org/10.1016/j.coi.2020.07.001.

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34

Kachikwu, Evelyn L., Keisuke S. Iwamoto, Yu-Pei Liao, et al. "Radiation Enhances Regulatory T Cell Representation." International Journal of Radiation Oncology*Biology*Physics 81, no. 4 (2011): 1128–35. http://dx.doi.org/10.1016/j.ijrobp.2010.09.034.

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35

Askenasy, Nadir, Ayelet Kaminitz, and Shai Yarkoni. "Mechanisms of T regulatory cell function." Autoimmunity Reviews 7, no. 5 (2008): 370–75. http://dx.doi.org/10.1016/j.autrev.2008.03.001.

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36

Ferreira, Leonardo M. R., Yannick D. Muller, Jeffrey A. Bluestone, and Qizhi Tang. "Next-generation regulatory T cell therapy." Nature Reviews Drug Discovery 18, no. 10 (2019): 749–69. http://dx.doi.org/10.1038/s41573-019-0041-4.

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37

Bharat, Ankit, Ryan Courtney Fields, and T. Mohanakumar. "Regulatory T Cell–Mediated Transplantation Tolerance." Immunologic Research 33, no. 3 (2006): 195–212. http://dx.doi.org/10.1385/ir:33:3:195.

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38

Probst-Kepper, Michael, Andrea Kröger, Henk S. P. Garritsen, and Jan Buer. "Perspectives on Regulatory T Cell Therapies." Transfusion Medicine and Hemotherapy 36, no. 5 (2009): 302–8. http://dx.doi.org/10.1159/000235929.

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39

Kanai, T., S. Seki, J. Jenks, and K. Nadeau. "Regulatory T cell regulation by STAT5B." Journal of Allergy and Clinical Immunology 129, no. 2 (2012): AB11. http://dx.doi.org/10.1016/j.jaci.2011.12.904.

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40

Baptista, Daniela, François Mach, and Karim J. Brandt. "Follicular regulatory T cell in atherosclerosis." Journal of Leukocyte Biology 104, no. 5 (2018): 925–30. http://dx.doi.org/10.1002/jlb.mr1117-469r.

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41

Mohr, Audrey, Rajneesh Malhotra, Gaell Mayer, Guy Gorochov, and Makoto Miyara. "Human FOXP3+T regulatory cell heterogeneity." Clinical & Translational Immunology 7, no. 1 (2018): e1005. http://dx.doi.org/10.1002/cti2.1005.

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42

Dikiy, Stanislav, and Alexander Y. Rudensky. "Principles of regulatory T cell function." Immunity 56, no. 2 (2023): 240–55. http://dx.doi.org/10.1016/j.immuni.2023.01.004.

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43

Canavan, James B., Behdad Afzali, Cristiano Scottà, et al. "A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy." Blood 119, no. 8 (2012): e57-e66. http://dx.doi.org/10.1182/blood-2011-09-380048.

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Abstract (sommario):

Abstract Regulatory T cells (CD4+CD25hiCD127loFOXP3+ T cells [Tregs]) are a population of lymphocytes involved in the maintenance of self-tolerance. Abnormalities in function or number of Tregs are a feature of autoimmune diseases in humans. The ability to expand functional Tregs ex vivo makes them ideal candidates for autologous cell therapy to treat human autoimmune diseases and to induce tolerance to transplants. Current tests of Treg function typically take up to 120 hours, a kinetic disadvantage as clinical trials of Tregs will be critically dependent on the availability of rapid diagnost

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44

Klein, Ludger, Ellen A. Robey, and Chyi-Song Hsieh. "Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation." Nature Reviews Immunology 19, no. 1 (2018): 7–18. http://dx.doi.org/10.1038/s41577-018-0083-6.

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45

Green, D. R., and H. Zheng. "Antigen-specific regulatory t-cell factors and the T-cell receptor." Research in Immunology 140, no. 3 (1989): 294–98. http://dx.doi.org/10.1016/0923-2494(89)90065-5.

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46

Yano, Hiroki, Takashi Ishida, Atsushi Inagaki, et al. "Regulatory T-cell function of adult T-cell leukemia/lymphoma cells." International Journal of Cancer 120, no. 9 (2007): 2052–57. http://dx.doi.org/10.1002/ijc.22536.

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47

Baek, DS, TH Chung, YH Kim, SK Oh, KM So, and C. Park. "Changes in regulatory T cells in dogs with B-cell lymphoma and association with clinical tumour stage." Veterinární Medicína 62, No. 12 (2017): 647–53. http://dx.doi.org/10.17221/7/2015-vetmed.

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Abstract (sommario):

Among several mechanisms that allow tumours to disarm the host immune system and thus to evade or suppress protective anti-tumour immunity, an important role for CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> regulatory T cells (Tregs) has emerged. Numerous studies in humans have demonstrated increased Tregs in patients with carcinomas of the breast, lung, and pancreas, and this increased Treg has been correlated with poor prognosis. This study was performed (1) to investigate the percentage of Tregs in total lymphocytes of the peripheral blood in 12 canin

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48

Beissert, Stefan, Agatha Schwarz, and Thomas Schwarz. "Regulatory T Cells." Journal of Investigative Dermatology 126, no. 1 (2006): 15–24. http://dx.doi.org/10.1038/sj.jid.5700004.

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49

Kofler, David M., Markus Chmielewski, Heike Koehler, et al. "Impact of Regulatory T Cells on Antigen Specific T Cell Response Using Recombinant Chimeric T Cell Receptors In Vivo." Blood 108, no. 11 (2006): 5475. http://dx.doi.org/10.1182/blood.v108.11.5475.5475.

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Abstract Recombinant T cell receptors with defined specificity against tumor cells are a promising experimental approach in the elimination of residual leukemia and lymphoma cells. It is so far unresolved whether regulatory T cells with suppressor activities impair the efficiency of cytolytic T cells grafted with a recombinant immunoreceptor. The frequency of regulatory T cells is highly increased in tumor patients and their suppressive function seems to play a role in the fail of an autologous T cell response against the malignant cells. In this study we analyzed the antigen-triggered, specif

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50

Won, Hee Yeon, and Eun Sook Hwang. "Transcriptional modulation of regulatory T cell development by novel regulators NR4As." Archives of Pharmacal Research 39, no. 11 (2016): 1530–36. http://dx.doi.org/10.1007/s12272-016-0803-z.

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