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Letteratura scientifica selezionata sul tema "Retroelement"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 25 luglio 2025

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Articoli di riviste sul tema "Retroelement"

Mustafin, R. N. "Participation of retroelements in chromoanagenesis in cancer development." Siberian journal of oncology 23, no. 5 (2024): 146–56. http://dx.doi.org/10.21294/1814-4861-2024-23-5-146-156.

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Purpose of the study: to determine the role of retroelements in chromoanagenesis mechanisms in cancer etiopathogenesis.Material and Methods. The search for relevant sources was carried out in the Scopus, Web of Science, PubMed, Elibrary systems, including publications from February 2002 to December 2023. Of the 864 scientifc articles found, 60 were used to write a systematic review.Results. According to original works and meta-analyses results, the cause of complex chromosomal rearrangements during cancer development may be retroelement pathological activation. Chromoanagenesis involves LINE1,

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Honda, Tomoyuki, Keiko Takemoto, and Keiji Ueda. "Identification of a Retroelement-Containing Human Transcript Induced in the Nucleus by Vaccination." International Journal of Molecular Sciences 20, no. 12 (2019): 2875. http://dx.doi.org/10.3390/ijms20122875.

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Endogenous retroelements constitute almost half of the mammalian genome. Given that more than 60% of human genomic bases are transcribed, transcripts containing these retroelements may impact various biological processes. However, the physiological roles of most retroelement-containing transcripts are yet to be revealed. Here, we profiled the expression of retroelement-containing human transcripts during vaccination and found that vaccination upregulated transcripts containing only particular retroelements, such as the MLT-int element of endogenous retroviruses. MLT-int-containing transcripts

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Springer, Mark S., Erin K. Molloy, Daniel B. Sloan, Mark P. Simmons, and John Gatesy. "ILS-Aware Analysis of Low-Homoplasy Retroelement Insertions: Inference of Species Trees and Introgression Using Quartets." Journal of Heredity 111, no. 2 (2019): 147–68. http://dx.doi.org/10.1093/jhered/esz076.

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Abstract DNA sequence alignments have provided the majority of data for inferring phylogenetic relationships with both concatenation and coalescent methods. However, DNA sequences are susceptible to extensive homoplasy, especially for deep divergences in the Tree of Life. Retroelement insertions have emerged as a powerful alternative to sequences for deciphering evolutionary relationships because these data are nearly homoplasy-free. In addition, retroelement insertions satisfy the “no intralocus-recombination” assumption of summary coalescent methods because they are singular events and bette

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Carotti, Elisa, Edith Tittarelli, Adriana Canapa, Maria Assunta Biscotti, Federica Carducci, and Marco Barucca. "LTR Retroelements and Bird Adaptation to Arid Environments." International Journal of Molecular Sciences 24, no. 7 (2023): 6332. http://dx.doi.org/10.3390/ijms24076332.

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TEs are known to be among the main drivers in genome evolution, leading to the generation of evolutionary advantages that favor the success of organisms. The aim of this work was to investigate the TE landscape in bird genomes to look for a possible relationship between the amount of specific TE types and environmental changes that characterized the Oligocene era in Australia. Therefore, the mobilome of 29 bird species, belonging to a total of 11 orders, was analyzed. Our results confirmed that LINE retroelements are not predominant in all species of this evolutionary lineage and highlighted a

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Murata, Hitoshi, and Akiyoshi Yamada. "marY1, a Member of the gypsyGroup of Long Terminal Repeat Retroelements from the Ectomycorrhizal Basidiomycete Tricholoma matsutake." Applied and Environmental Microbiology 66, no. 8 (2000): 3642–45. http://dx.doi.org/10.1128/aem.66.8.3642-3645.2000.

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ABSTRACT We cloned an intact copy of a long terminal repeat retroelement designated marY1 from the ectomycorrhizal basidiomyceteTricholoma matsutake. The reverse transcriptase domain is found in T. matsutake and Tricholoma magnivelare worldwide. This finding suggests that retroelements associate with ectomycorrhizal basidiomycetes and may be useful as genetic markers for identification, phylogenetic analysis, and mutagenesis of this fungal group.

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Chung, Kevin, Ling Xu, Pengxin Chai, Junhui Peng, Swapnil C. Devarkar, and Anna Marie Pyle. "Structures of a mobile intron retroelement poised to attack its structured DNA target." Science 378, no. 6620 (2022): 627–34. http://dx.doi.org/10.1126/science.abq2844.

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Group II introns are ribozymes that catalyze their self-excision and function as retroelements that invade DNA. As retrotransposons, group II introns form ribonucleoprotein (RNP) complexes that roam the genome, integrating by reversal of forward splicing. Here we show that retrotransposition is achieved by a tertiary complex between a structurally elaborate ribozyme, its protein mobility factor, and a structured DNA substrate. We solved cryo–electron microscopy structures of an intact group IIC intron-maturase retroelement that was poised for integration into a DNA stem-loop motif. By visualiz

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Ishak, Charles A., and Daniel D. De Carvalho. "Reactivation of Endogenous Retroelements in Cancer Development and Therapy." Annual Review of Cancer Biology 4, no. 1 (2020): 159–76. http://dx.doi.org/10.1146/annurev-cancerbio-030419-033525.

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Domesticated retroelements contribute extensively as regulatory elements within host gene networks. Upon germline integration, retroelement mobilization is restricted through epigenetic silencing, mutational degradation, and innate immune defenses described as the viral mimicry response. Recent discoveries reveal how early events in tumorigenesis reactivate retroelements to facilitate onco-exaptation, replication stress, retrotransposition, mitotic errors, and sterile inflammation, which collectively disrupt genome integrity. The characterization of altered epigenetic homeostasis at retroeleme

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Mota, Ines Frutuoso, Jaspreet Osean, Eric Song, et al. "Characterization of the HLA-F ligandome in T-cell lymphoma." Journal of Immunology 210, no. 1_Supplement (2023): 222.06. http://dx.doi.org/10.4049/jimmunol.210.supp.222.06.

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Abstract Identifying tumor-specific antigens across different types of malignancies and HLA haplotypes remains challenging. Recently, the expression of tumor-specific Human Endogenous Retroelements emerged as a potential new class of cytotoxic T-cell response mediators (1). HLA-F, a non-classic HLA-I molecule, has been hypothesized to present peptides to T-cells and to regulate immunity through interactions with distinct NK-cell receptors (2). HLA-F low genetic diversity and limited peptide repertoire represent an unexplored avenue in cancer immunotherapy. HLA-F-bound peptides were eluted from

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Lee, Gloria, Nicholas A. Sherer, Neil H. Kim, et al. "Testing the retroelement invasion hypothesis for the emergence of the ancestral eukaryotic cell." Proceedings of the National Academy of Sciences 115, no. 49 (2018): 12465–70. http://dx.doi.org/10.1073/pnas.1807709115.

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Phylogenetic evidence suggests that the invasion and proliferation of retroelements, selfish mobile genetic elements that copy and paste themselves within a host genome, was one of the early evolutionary events in the emergence of eukaryotes. Here we test the effects of this event by determining the pressures retroelements exert on simple genomes. We transferred two retroelements, human LINE-1 and the bacterial group II intron Ll.LtrB, into bacteria, and find that both are functional and detrimental to growth. We find, surprisingly, that retroelement lethality and proliferation are enhanced by

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Furini, Antonella. "CDT retroelement." Plant Signaling & Behavior 3, no. 12 (2008): 1129–31. http://dx.doi.org/10.4161/psb.3.12.7076.

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Tesi sul tema "Retroelement"

Thomson, Gabrielle Anne Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Retroelements as controlling elements in mammals." Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/26203.

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Retroelements are genomic parasites which make up ~42% of the human genome and 38% of the mouse genome. Most are degenerate, but a large number have relatively intact promoter elements, suggesting that they are capable of transcription. Transcriptionally active retroelements can perturb normal transcription units in their vicinity through a variety of mechanisms, leading to phenotypic effects and in some cases disease. This phenomenon of transcriptional interference has been observed in organisms as diverse as maize, Drosophila, and the mouse. We analysed the extent of retroelement transcr

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ORICCHIO, ELISA. "I retroelementi nella tumorigenesi: ruoli distinti di LINE-1 ed HERV-K nella progressione tumorale." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/399.

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I retroelementi sono sequenze altamente ripetute disperse nel genoma, che codificano per una Trascrittasi Inversa (RT). Cellule e tessuti caratterizzati da una elevata capacità di proliferazione e un basso grado di differenziamento (come cellule tumorali o embrionali) esprimono alti livelli di RT che al contrario è scarsamente espressa in tessuti terminalmente differenziati. E’ noto da precedenti studi condotti nel nostro laboratorio che il trattamento di diverse linee cellulari tumorali con due inibitori non nucleosidici della RT, la nevirapina ed l’efavirenz, induce una riduzione dell

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Lightbourn, Gordon James. "Development of intermonoploid somatic hybrids of potato and their molecular analysis based on polymorphism for retroelement Tst1." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/28810.

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Inbred lines for hybrid crop production have been a mainstay of plant breeding. Biotechnological approaches to hasten the process are available including anther culture to halve the genome and protoplast fusion to create hybrids between incompatible partners. We applied these techniques to potato to evaluate their potential for breeding highly heterozygous, cross-pollinating species. Four families of monoploids (2n=1x=12), developed from diploid hybrids with diverse genomic constitutions but heavily favoring Solanum phureja, a primitive cultivated potato, were used in electrofusion experiments

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Meyn, Malcolm Anthony 1967. "A genetic, biochemical, and population analysis of MGL, a non-LTR retroelement from the plant pathogenic fungus Magnaporthe grisea." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/288755.

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This dissertation describes the characterization of a novel transposable element isolated from the plant pathogenic fungus Magnaporthe grisea. The sequence of MGR583, a previously reported repeated DNA fragment, was completed and shown to have features characteristic of non-LTR retroelements (LINEs). These include an element length of 5.9 kb, the lack of flanking long terminal repeats, the presence of short (6-13 bp) direct repeats flanking many element copies, and two principal open reading frames (ORFs). The first ORF is 570 amino acids in length and contains homology to the gag ORFs found

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Volkmann, Bianca [Verfasser], Thomas [Akademischer Betreuer] Gramberg, Andreas [Gutachter] Burkovski, and Andreas [Gutachter] Burkovski. "The role of TRIM proteins in retrovirus and retroelement restriction / Bianca Volkmann ; Gutachter: Andreas Burkovski, Andreas Burkovski ; Betreuer: Thomas Gramberg." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1216332967/34.

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Adhya, Indranil. "Exhaustive Identification of the retroelement Ty1 Integrase partners in yeast Saccharomyces cerevisiae : characterization of the role of Casein kinase II in Ty1 retrotransposition in vivo." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS589.

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Les rétrotransposons LTR sont des éléments transposables très répandus chez les eucaryotes. Comme les rétrovirus, ils se répliquent par transcription inverse de leur ARN en ADNc, qui est intégré dans le génome hôte par leur propre intégrase (IN). Des études de séquençage à haut débit ont clairement établi que l'intégration ne se fait pas de façon aléatoire dans l'ensemble du génome de la cellule hôte. Des connaissances approfondies sur la biologie rétrovirale ont été acquises grâce à leur étude sur la levure utilisant le Ty1 LTR-retrotransposon comme modèle de travail. Le rétrotransposon Ty1 d

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Hodes, Asher Benjamin. "Diversity-generating retroelements." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1835260431&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Nottensteiner, Mathias [Verfasser], Ralph [Akademischer Betreuer] [Gutachter] Hückelhoven, Erich J. [Gutachter] Glawischnig, and Aurélien [Gutachter] Tellier. "Molecular Characterization of Retroelement Encoded ROPIP1 as Virulence Effector of Blumeria graminis f.sp. hordei / Mathias Nottensteiner ; Gutachter: Erich J. Glawischnig, Aurélien Tellier, Ralph Hückelhoven ; Betreuer: Ralph Hückelhoven." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/112273834X/34.

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Wilson, Williamina. "Ribosomal frameshifting in retroelements." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670301.

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Mu, Sen. "Detection of Bacterial Retroelements Using Genomics." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etd/1110.

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The reverse flow of genetic information can occur when a special DNA polymerase called Reverse Transcriptase (RT) copies the genetic information in an RNA molecule back into a complementary DNA. One type of RT encoding gene found in bacteria is called a retron element. Recent bacterial genome sequencing projects have revealed many examples of retron RT genes. This gene assignment is based on comparison with a few known retron RT proteins. However, RT proteins are highly diverse in their amino acid sequences, and thus the assigned identity of these RT proteins as retrons in genome databases is

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Libri sul tema "Retroelement"

Yves, Christen, and SpringerLink (Online service), eds. Retrotransposition, Diversity and the Brain. Springer-Verlag, 2008.

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Brindley, Paul J. Mobile genetic elements in metazoan parasites. Landes Bioscience, 2009.

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Koito, Atsushi, and Yukihito Ishizaka, eds. Retroviruses, retroelements and their restrictions. Frontiers SA Media, 2015. http://dx.doi.org/10.3389/978-2-88919-401-8.

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Lochmüller, Hanns. Beiträge zur Charakterisierung eines neuen Retroelements (Ty4) aus der Hefe Saccharomyces cerevisiae. 1991.

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Mobile genetic elements in metazoan parasites. Landes Bioscience, 2009.

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Capitoli di libri sul tema "Retroelement"

Refsland, Eric W., and Reuben S. Harris. "The APOBEC3 Family of Retroelement Restriction Factors." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-37765-5_1.

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Chalopin, Domitille, Marta Tomaszkiewicz, Delphine Galiana, and Jean-Nicolas Volff. "LTR Retroelement-Derived Protein-Coding Genes and Vertebrate Evolution." In Viruses: Essential Agents of Life. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4899-6_13.

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Fujii, Yoichi Robertus. "The RNA Gene Information: Retroelement-MicroRNA Entangling as the RNA Quantum Code." In MicroRNA Protocols. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-083-0_4.

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Garfinkel, David J. "Retroelements in Microorganisms." In The Retroviridae. Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3372-6_4.

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Hull, Roger, and Simon N. Covey. "Retroelements: Propagation and Adaptation." In Molecular Evolution of Viruses — Past and Present. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1407-3_4.

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Leib-Mösch, Christine, and Wolfgang Seifarth. "Evolution and Biological Significance of Human Retroelements." In Molecular Evolution of Viruses — Past and Present. Springer US, 1996. http://dx.doi.org/10.1007/978-1-4613-1407-3_6.

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Richert-Pöggeler, Katja R., and Trude Schwarzacher. "Impact of Retroelements in Shaping the Petunia Genome." In Petunia. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-84796-2_16.

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Guo, Huatao, Li Arambula, Partho Ghosh, and Jeff F. Miller. "Diversity-generating Retroelements in Phage and Bacterial Genomes." In Mobile DNA III. ASM Press, 2015. http://dx.doi.org/10.1128/9781555819217.ch53.

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Brosius, Jürgen. "Genomes were forged by massive bombardments with retroelements and retrosequences." In Transposable Elements and Genome Evolution. Springer Netherlands, 2000. http://dx.doi.org/10.1007/978-94-011-4156-7_23.

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Román, Ángel Carlos, Antonio Morales-Hernández, and Pedro M. Fernández-Salguero. "RNA-Seq Analysis to Measure the Expression of SINE Retroelements." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3372-3_7.

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Atti di convegni sul tema "Retroelement"

Panina, E. A., I. V. Babkin, V. A. Fedorets, and N. V. Tikunova. "ANALYSIS OF PHAGE DGR CASSETTES ON THE BASIS OF THE EXAMPLE OF PHAGE LMMB." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-265.

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DGR cassettes are Diversity Generating Retroelements (DGRs), a recently discovered class of retroelements that utilize reverse transcription to generate a huge number of sequence variants in specific target genes. In the Laboratory of Molecular Microbiology of ICBFM SB RAS, a new crAss-like genome containing a diversity-generating retroelement was discovered during the study of a sample of human virome.

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Cooles, Faye, Gemma Vidal Pedrola, Amy Anderson, et al. "AB0024 WHOLE BLOOD ENDOGENOUS RETROELEMENT ACTIVITY ASSOCIATES WITH ANTI-CCP TITRES IN EARLY DRUG NAïVE RA AND IS PREFERENTIALLY INCREASED IN CD5+ AND NAïVE B CELLS." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.2980.

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Solovyova, A. I., A. A. Ponomaryova, E. Yu Rykova та ін. "СIRCULATING DNA-MARKERS FOR PROGNOSIS AND PREDICTION OF ANTITUMOR THERAPY IN COLORECTAL CANCER". У X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-374.

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Colorectal cancer (CRC) is one of the frequent malignant diseases worldwide. The analysis of epigenetic factors contributed to the CRC development is needed for improvement of diagnostic and therapeutic strategies. “Liquid biopsy” seems to be an adequate approach to detect changes associated with cancer. This study devoted to investigation of methylation of LINE-1 retroelements and SEPTIN9, IKZF1 genes in blood cirDNA from CRC patients before and after treatment.

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Leonova, Katerina, Brittany Lipchick, Leonid Brodsky, Elena Komarova, and Andrei V. Gudkov. "Abstract 2959: p53 as a guardian of genomic junk: A novel role for p53 in epigenetic silencing of retroelements." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2959.

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Mavragani, Clio, Kyriakos Kirou, Adrianos Nezos, et al. "THU0228 EXPRESSION OF APOBEC FAMILY MEMBERS AS REGULATORS OF ENDOGENOUS RETROELEMENTS AND MALIGNANCY IN SYSTEMIC LUPUS ERYTHEMATOSUS AND SJÖGREN’S SYNDROME." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.6152.

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Mavragani, Clio P., Irina Sagalovskiy, Qiu Guo, et al. "I-06 Long interspersed nuclear element-1 retroelements are expressed in patients with systemic lupus erythematosus and primary SJOGREN’S syndrome and induce type I interferon." In Abstracts of the Third Biannual Scientific Meeting of the North and South American Lupus Community, Armonk, New York, USA, September 29 – October 1, 2016. Lupus Foundation of America, 2016. http://dx.doi.org/10.1136/lupus-2016-000179.71.

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Rapporti di organizzazioni sul tema "Retroelement"

Belancio, Victoria P., and Prescott L. Deininger. Retroelements and Genetic Instability in Breast Cancer. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada436906.

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Perepelitsa, Victoria P. Retroelements and Genetic Instability in Breast Cancer. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada424037.

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Belancio, Victoria P., and Prescott L. Deininger. Retroelements and Genetic Instability in Breast Cancer. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada425722.

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Avihingsanon, Yingyos, Jongkonnee Wongpiyabovorn, and Nattiya Hirankarn. Biomarker discovery in systemic lupus erythematosus: genome-methylation approaches : Research report. Chulalongkorn University, 2010. https://doi.org/10.58837/chula.res.2010.15.

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Discovery of novel biomarkers in lupus nephritis Biomarkers are needed for making diagnosis and prognosis. In lupus nephritis, conventional tests like urinalysis or serum creatinine remain inadequate for patient care. In this proposal, we focused on non-invasive tools like blood and urine mRNAs or proteins. We chose candidate genes involving regulatory T-cell, B-lymphocyte signatures or vascular protective factors. Expression of regulatory cell signature (FOXP3) in peripheral blood mononuclear cells is associated with activity of lupus nephritis. We found FOXP3 mRNA levels in PBMCs from patien

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