Accedi

Bibliografie tematiche / SIGNALLING MECHANISM / Libri

Segui questo link per vedere altri tipi di pubblicazioni sul tema: SIGNALLING MECHANISM.

Libri sul tema "SIGNALLING MECHANISM"

Autore: Grafiati

Pubblicato: 11 settembre 2023

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Vedi i top-50 libri per l'attività di ricerca sul tema "SIGNALLING MECHANISM".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Vedi i libri di molte aree scientifiche e compila una bibliografia corretta.

1

1927-, Segawa Tomio, a cura di. Physiology and pharmacology of transmembrane signalling: Proceedings of the Uehara Memorial Foundation Symposium on the Mechanism of Transmembrane Signalling, Tokyo, Japan May 12-14, 1988. Amsterdam: Excerpta Medica, 1989.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

1945-, Cohen P., e Houslay Miles D, a cura di. Molecular mechanisms of transmembrane signalling. Amsterdam: Elsevier, 1985.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Frank, Entschladen, e Zänker Kurt S, a cura di. Cell migration: Signalling and mechanisms. Basel: Karger, 2010.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

M, Harnett Margaret, e Rigley Kevin P, a cura di. Lymphocyte signalling: Mechanisms, subversion, and manipulation. Chichester: J. Wiley, 1997.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Wirtz, Karel W. A., a cura di. Molecular Mechanisms of Signalling and Membrane Transport. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60799-8.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Brumell, John H. Phosphorylation-dependent signalling mechanisms in human neutrophils. Ottawa: National Library of Canada = Bibliothèque nationale du Canada, 1997.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Packer, Lester, e Karel W. A. Wirtz, a cura di. Signalling Mechanisms — from Transcription Factors to Oxidative Stress. Berlin, Heidelberg: Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79675-3.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Davies, Clare Charlotte. Mechanisms of CD40 signalling and apoptosis in carcinoma cells. Birmingham: University of Birmingham, 2003.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

9

O'Connor, Rodney Philip. A relationship between the amplitude and spectral characteristics of the geomagnetic field and the occurrence of sudden infant death in Canada: A possible cellular mechanism supported by a mathematical modeland experimental evidence for involvement of calcium signalling and nitric oxide. Sudbury, Ont: Laurentian University, Department of Biology, 2001.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

H, Michell R., Drummond Alan H e Downes C. Peter, a cura di. Inositol lipids in cell signalling. London: Academic Press, 1989.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

11

Singh, Pratibha, Rajiv Kumar Singh, Madhulika Singh e Sheo Mohan Prasad. Physiology of Salt Stress in Plants: Perception, Signalling, Omics and Tolerance Mechanism. Wiley & Sons, Incorporated, John, 2021.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

12

Singh, Pratibha, Rajiv Kumar Singh, Madhulika Singh e Sheo Mohan Prasad. Physiology of Salt Stress in Plants: Perception, Signalling, Omics and Tolerance Mechanism. Wiley & Sons, Incorporated, John, 2021.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

13

Singh, Pratibha, Rajiv Kumar Singh, Madhulika Singh e Sheo Mohan Prasad. Physiology of Salt Stress in Plants: Perception, Signalling, Omics and Tolerance Mechanism. Wiley & Sons, Incorporated, John, 2021.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

14

Physiology of Salt Stress in Plants: Perception, Signalling, Omics and Tolerance Mechanism. Wiley & Sons, Incorporated, John, 2021.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

15

Watanabe, Tetsuya. Biophysical Basis of Physiology and Calcium Signalling Mechanism in Cardiac and Smooth Muscle. Elsevier Science & Technology, 2018.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

16

D’Amato, Gaetano, Guillermo Luxán e José Luis de la Pompa. Defining cardiac domains from the inside: NOTCH in endocardial–myocardial interactions. A cura di José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso e Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0011.

Testo completo

Abstract (sommario):

In this chapter we illustrate the signalling interactions of the endocardium with the other cardiac tissues to coordinate cardiac development. First, we describe the developmental origins of the endocardium. Then we focus on the Notch pathway because of its unique signalling activity in the endocardium, and briefly describe the elements of this signalling mechanism and the key cardiogenic processes that require endocardial Notch signalling: patterning of the early embryonic endocardium into prospective territories for valves and ventricular chambers, early valve formation, ventricular trabeculation, and compaction. Finally, we discuss how Notch dysfunction in the endocardium results in cardiac structural malformations that can lead to congenital heart disease.

Gli stili APA, Harvard, Vancouver, ISO e altri

17

Entschladen, F., e K. S. Z�nker, a cura di. Cell Migration: Signalling and Mechanisms. S. Karger AG, 2009. http://dx.doi.org/10.1159/isbn.978-3-8055-9322-9.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

18

Thiery, J. P. Molecular Mechanisms of Transcellular Signalling. A cura di J. P. Thiery. I O S PRESS, 1999.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

19

Monaco, Claudia, e Giuseppina Caligiuri. Molecular mechanisms. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0014.

Testo completo

Abstract (sommario):

The development of the atherosclerotic plaque relies on specific cognate interactions between ligands and receptors with the ability to regulate cell recruitment, inflammatory signalling, and the production of powerful inflammatory and bioactive lipid mediators. This chapter describes how signalling is engaged by cell-cell surface interactions when the endothelium interacts with platelets and leukocytes enhancing leukocyte recruitment during atherogenesis. It also exemplifies intracellular signalling pathways induced by the activation of innate immune receptors, the most potent activators of inflammation in physiology and disease. Differences are highlighted in innate signalling pathways in metabolic diseases such as atherosclerosis compared to canonical immunological responses. Finally, the key lipid mediators whose production can affect endothelial function, inflammation, and atherosclerosis development are summarized. This Chapter will take you through these fundamental steps in the development of the atherosclerotic plaque by summarizing very recent knowledge in the field and highlighting recent or ongoing clinical trials that may enrich our ability to target cardiovascular disease in the future.

Gli stili APA, Harvard, Vancouver, ISO e altri

20

(Editor), Margaret M. Harnett, e Kevin P. Rigley (Editor), a cura di. Lymphocyte Signalling: Mechanisms, Subversion and Manipulation. John Wiley & Sons, 1997.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

21

Molecular mechanisms of signalling and membrane transport. Berlin: Springer, 1997.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

22

Wirtz, Karel W. A. Molecular Mechanisms of Signalling and Membrane Transport. Springer London, Limited, 2013.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

23

Witzel, Franziska, Titus Stahl e Julia Christ. Mechanisms Conferring Robustness to Erk1/2 Signalling. Logos Verlag Berlin, 2015.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

24

Wirtz, Karel W. A. Molecular Mechanisms of Signalling and Membrane Transport ). Springer, 2011.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

25

Wirtz, Karel W. A. Molecular Mechanisms of Signalling and Membrane Transport. Springer, 2011.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

26

Signalling mechanisms-- from transcription factors to oxidative stress. [Berlin: Springer-Verlag, 1995.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

27

Packer, Lester, e Karel W. A. Wirtz. Signalling Mechanisms -- from Transcription Factors to Oxidative Stress. Springer London, Limited, 2013.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

28

Packer, Lester, e Karel W. A. Wirtz. Signalling Mechanisms - From Transcription Factors to Oxidative Stress. Springer London, Limited, 2012.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

29

Hormones and Cell Signalling. Guilford Pr, 1990.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

30

Singh, Vijay Pratap, Sheo Mohan Prasad e Samiksha Singh. Mechanisms Behind Phytohormonal Signalling and Crop Abiotic Stress Tolerance. Nova Science Publishers, Incorporated, 2017.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

31

Cytoskeleton: Signalling and Cell Regulation: A Practical Approach. Oxford University Press, USA, 2000.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

32

L, Carraway K., e Carraway C. A. C, a cura di. Cytoskeleton: Signalling and cell regulation : a practical approach. New York: Oxford University Press, 2000.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

33

Adinolfi, Elena, Lin-Hua Jiang e Sébastien Roger, a cura di. Ion Channel Signalling in Cancer: From Molecular Mechanisms to Therapeutics. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-124-6.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

34

Mehra, Arun. Mechanisms of signalling and antagonism in the TGF[Beta] superfamily. 2002.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

35

(Editor), Kermit L. Carraway, e Carolie A. Carothers Carraway (Editor), a cura di. Cytoskeleton: Signalling and Cell Regulation: A Practical Approach (Practical Approach Series). Oxford University Press, USA, 2000.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

36

Hua, Hong. Mechanisms of high glucose-induced altered endothelin-1 signalling in glomerular mesangial cells. 2003.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

37

Coecke, Bob, e Aleks Kissinger. Categorical Quantum Mechanics I: Causal Quantum Processes. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198748991.003.0012.

Testo completo

Abstract (sommario):

We derive the category-theoretic backbone of quantum theory from a process ontology. More specifically, we treat quantum theory as a theory of systems, processes, and their interactions. We first present a general theory of diagrams, and in particular, of string diagrams, and discuss why diagrams are a very natural starting point for developing scientific theories. Then we define process theories, and define a very general notion of quantum type. We show how our process ontology enables us to assert causality, that is, compatibility of quantum theory and relativity theory, prove the no-signalling theorem, provide a new elegant derivation of the no-broadcasting theorem, unitarity of evolution, and Stinespring dilation, all for any `quantum' type in a general class of process theories.

Gli stili APA, Harvard, Vancouver, ISO e altri

38

Rammah, Mayyasa, Francesca Rochais e Robert G. Kelly. Incorporation of myocardial progenitors at the arterial pole of the heart. A cura di José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso e Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0007.

Testo completo

Abstract (sommario):

The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). It is formed by progressive addition of myocardium from epithelial progenitor cells in the second heart field (SHF). SHF cells contribute successively to the right ventricle and proximal and distal outflow tract myocardial walls which, after neural crest influx and cardiac septation, give rise to myocardium at the base of the aorta and pulmonary trunk. SHF cells are characterized by continued proliferation and differentiation delay controlled by an array of transcriptional regulators and signalling pathways which define the SHF progenitor cell niche in pharyngeal mesoderm. Failure of normal SHF deployment leads to a shortened outflow tract and failure of ventriculo-arterial alignment, resulting in a spectrum of conotruncal CHD. We discuss the origins of the SHF in cardiopharyngeal mesoderm and focus on the mechanisms driving SHF deployment, summarizing current understanding of critical signalling pathways and transcription factors.

Gli stili APA, Harvard, Vancouver, ISO e altri

39

Endlich, Karlhans, e Rodger Loutzenhiser. Regulation of vasomotor tone in the afferent and efferent arterioles. A cura di Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0208.

Testo completo

Abstract (sommario):

Pre-glomerular vessels are regulated by membrane potential alterations affecting the activity of L-type voltage-activated Ca2+ channels; whereas voltage-independent mechanisms regulate the efferent arteriole, notably influenced by angiotensin II and therefore by angiotensin converting enzyme inhibitors, and by non-steroidal anti-inflammatory drugs.These properties underlie the physiologic control of glomerular capillary pressure, for example, by prostaglandin E2, during conditions of reduced renal perfusion and the stabilization of glomerular capillary pressure when the kidney is exposed to pressure fluctuations. A wealth of hormones affects the tone of renal vessels. The chapter focuses on basic regulatory and signalling mechanisms, emphasizing the unique aspects of the renal vasculature and the underlying features that facilitate the independent regulation of pre-glomerular and post-glomerular tone.

Gli stili APA, Harvard, Vancouver, ISO e altri

40

The effect of thrombin on the shape of and the microfilament distribution in porcine aortic endothelial cells: Possible cellular signalling mechanisms. Ottawa: National Library of Canada, 1992.

Cerca il testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

41

Wordsworth, B. P. Skeletal dysplasias. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0150.

Testo completo

Abstract (sommario):

Bone is metabolically active throughout life and metabolic disturbances may have wide-ranging consequences that are not restricted to altering its mechanics. The study of some genetic bone diseases has already provided remarkable insights into the normal regulation of bone metabolism. Skeletal dysplasias are developmental disorders of the chondro-osseous tissues commonly resulting in short stature, which is often disproportionate. The underlying mutations are often in the structural genes encoding components of the matrix but may also involve growth factors or cell signalling. In contrast, the dysostoses tend to affect single bones or groups of bones, reflecting the transient nature of the many different signalling factors to which they are responsive during development. Abnormalities of bone density (high or low) may be due to primary deficiency of bone matrix synthesis (e.g. osteogenesis imperfecta and hypophosphatasia) but may also reflect an imbalance between bone formation and resorption. This may be caused by abnormalities of bone formation (e.g. hyperostosis/sclerosteosis and osteoporosis pseudoglioma syndrome) or bone resorption (e.g. classic osteopetrosis and fibrous dysplasia).

Gli stili APA, Harvard, Vancouver, ISO e altri

42

Puthucheary, Zudin, Hugh Montgomery, Nicholas Hart e Stephen Harridge. Skeletal Muscle Mass Regulation in Critical Illness. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0035.

Testo completo

Abstract (sommario):

Muscle is a dynamic, plastic, and malleable tissue that is highly sensitive to mechanical and metabolic signals. Muscle mass is regulated by protein homeostasis, with protein being continually turned over, reflecting a balance between synthesis and breakdown. This chapter discusses the effect of critical illness on skeletal muscle mass, protein homeostasis, and the intracellular signalling driving anabolism and catabolism. The focus will be on the unique challenges to which the skeletal muscle are exposed, such as inflammation, sepsis, sedation, and inadequate nutrition, which, in combination with the disuse signals of immobilization and bed rest, engender dramatic changes in muscle structure and function. The mechanisms regulating muscle loss during critical illness are being unravelled, but many questions remain unanswered. Detailed understanding of these mechanisms will help drive strategies to minimize or prevent intensive care-acquired muscle weakness and the long-term consequences experienced by ICU survivors.

Gli stili APA, Harvard, Vancouver, ISO e altri

43

Carmeliet, Peter, Guy Eelen e Joanna Kalucka. Arteriogenesis versus angiogenesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0008.

Testo completo

Abstract (sommario):

Higher organisms have a cardiovascular circulatory system with blood vessels to supply vital nutrients and oxygen to distant tissues. It is therefore not surprising that vascular disorders are leading causes of mortality. Understanding how new blood vessels form, creates opportunities to cure these life-threatening diseases. After birth, growth of blood vessels mainly occurs via two distinct mechanisms depending on the initial trigger: angiogenesis (referred here as capillary sprouting) is induced primarily by hypoxia, whereas arteriogenesis (referred here as the rapid enlargement of pre-existing collateral arteries, induced by vascular occlusion) is mainly driven by fluid shear stress. Arteriogenesis allows conductance of much larger volumes of blood per unit of time than does the increase in capillary density during angiogenesis. Notwithstanding these major differences, angiogenesis and arteriogenesis share a number of underlying mechanisms, e.g. the involvement of growth factor signalling. This chapter highlights the cellular and molecular events driving the two processes and discusses the therapeutic potential of targeting angiogenesis in cancer and arteriogenesis in cardiovascular diseases.

Gli stili APA, Harvard, Vancouver, ISO e altri

44

McNamara, John M., e Olof Leimar. Game Theory in Biology. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198815778.001.0001.

Testo completo

Abstract (sommario):

Game theory in biology seeks to predict social behaviour and other traits that influence how individuals interact. It does this by tentatively assuming that current traits are stable endpoints of evolution by natural selection. The theory is used to model aggressive behaviour, cooperation, negotiation, and signalling, as well as phenotypic attributes like an individual’s sex and mating type. This book covers the basic concepts and the traditional examples of biological game theory. It expands the frontiers of the field, emphasizing the importance of the co-evolution of traits and the implications of variation for reputation, markets, negotiation, and other social phenomena. It also highlights that it can be important to embed game interactions in the environment and an individual’s life. A major new direction developed in the book is that game theory can be extended by incorporating behavioural mechanisms, including mechanisms of reinforcement learning. By doing this the theory can successfully describe important phenomena like social dominance in group-living animals that previously have been difficult to model. By focusing on behavioural mechanisms, game theory can also make closer contact with empirical observation and with current research in fields like animal psychology and neuroscience.

Gli stili APA, Harvard, Vancouver, ISO e altri

45

Gordon-Williams, Richard M., e Anthony H. Dickenson. Pathophysiology of pain in cancer and other terminal illnesses. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0092.

Testo completo

Abstract (sommario):

Cancer pain involves a myriad of peripheral changes in the function of tissue and nerves, at the site of the tumour growth, as well as a number of consequent changes in the processing of pain messages at the spinal cord level with implications for the pain experience at higher centres. This chapter reviews the changes in peripheral pain signalling, notes the likely prevalence of both inflammatory and neuropathic components, and describes the altered events at spinal levels that can come some way towards explaining ongoing pain, hyperalgesia, and allodynias that patients with cancer and other terminal illnesses such as HIV/AIDs experience. Finally, changes induced by cancer at the level of the brain are discussed. The mechanisms of action of therapies, both existing and potential novel approaches, are included at peripheral and central levels.

Gli stili APA, Harvard, Vancouver, ISO e altri

46

Olzer, Rachel, Rebecca L. Ehrlich, Justa L. Heinen-Kay, Jessie Tanner e Marlene Zuk. Reproductive behavior. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198797500.003.0013.

Testo completo

Abstract (sommario):

Sex and reproduction lie at the heart of studies of insect behavior. We begin by providing a brief overview of insect anatomy and physiology, followed by an introduction to the overarching themes of parental investment, sexual selection, and mating systems. We then take a sequential approach to illustrate the diversity of phenomena and concepts behind insect reproductive behavior from pre-copulatory mate signalling through copulatory sperm transfer, mating positions, and sexual conflict, to post-copulatory sperm competition, and cryptic female choice. We provide an overview of the evolutionary mechanisms driving reproductive behavior. These events are linked by the economic defendability of mates or resources, and how these are allocated in each sex. Under the framework of economic defendability, the reader can better understand how sexual antagonistic behaviors arise as the result of competing optimal fitness strategies between males and females.

Gli stili APA, Harvard, Vancouver, ISO e altri

47

Valdes, Ana M. Genetics. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0009.

Testo completo

Abstract (sommario):

Epidemiological studies have demonstrated that osteoarthritis (OA) is a complex trait with numerous environmental and genetic risk factors. A great deal of effort has been spent elucidating these risk factors and progress has been made. It is clear however that the causes behind OA development and progression continue to remain largely elusive. Identification of those genes that, in conjunction with environmental factors, predispose to OA severity will lead to a better understanding of the mechanisms underlying disease development and thus promote improved health strategies for prevention. An understanding of the molecular signalling pathways involved in the initiation and progression of the disease will improve clinical diagnosis and help identify improved, tailored treatment regimens. This chapter focuses on these issues, exploring the heritability of OA, known genetic risk factors, and specific traits and outcomes studied in the genetics of OA.

Gli stili APA, Harvard, Vancouver, ISO e altri

48

Rosengart, Matthew R. Disorders of calcium in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0253.

Testo completo

Abstract (sommario):

Calcium is vitally important for normal cellular signalling and function. However, its toxicity necessitates that intracellular calcium concentration [Ca2+] be tightly regulated and compartmentalized. Evolutionary pressures have yielded several regulatory mechanisms to maintain intracellular and extracellular ionized calcium concentrations compatible with life. During periods of critical illness these process are commonly overwhelmed, and disorders of calcium homeostasis are highly prevalent among intensive care unit (ICU) patients. Indeed, hypocalcaemia occurs in up to 88% of critically-ill ICU patients suffering from trauma, sepsis, and burns. Contemporary evidence suggests that although hypocalcaemia may be associated with ICU mortality, it is not in the causal pathway. A systematic review concluded there are no data to support the routine parenteral administration of calcium in the management of asymptomatic critical illness-related hypocalcaemia. Asymptomatic hypocalcaemia of critical illness does not necessitate replacement. However, acute, symptomatic hypocalcaemia necessitates parenteral supplementation to prevent tetany, seizures, and cardiac arrhythmias

Gli stili APA, Harvard, Vancouver, ISO e altri

49

Guzik, Tomasz J., e Rhian M. Touyz. Vascular pathophysiology of hypertension. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198755777.003.0019.

Testo completo

Abstract (sommario):

Hypertension is a multifactorial disease, in which vascular dysfunction plays a prominent role. It occurs in over 30% of adults worldwide and an additional 30% are at high risk of developing the disease. Vascular pathology is both a cause of the disease and a key manifestation of hypertension-associated target-organ damage. It leads to clinical symptoms and is a key risk factor for cardiovascular disease. All layers of the vascular wall and the endothelium are involved in the pathogenesis of hypertension. Pathogenetic mechanisms, whereby vascular damage contributes to hypertension, are linked to increased peripheral vascular resistance. At the vascular level, processes leading to change sin peripheral resistance include hyper-contractility of vascular smooth muscle cells, endothelial dysfunction, and structural remodelling, due to aberrant vascular signalling, oxidative and inflammatory responses. Increased vascular stiffness due to vascular remodelling, adventitial fibrosis, and inflammation are key processes involved in sustained and established hypertension. These mechanisms are linked to vascular smooth muscle and fibroblast proliferation, migration, extracellular matrix remodelling, calcification, and inflammation. Apart from the key role in the pathogenesis of hypertension, hypertensive vasculopathy also predisposes to atherosclerosis, another risk factor for cardiovascular disease. This is linked to increased transmural pressure, blood flow, and shear stress alterations in hypertension, as well as endothelial dysfunction and vascular stiffness. Therefore, understanding the mechanisms and identifying potential novel treatments targeting hypertensive vasculopathy are of primary importance in vascular medicine.

Gli stili APA, Harvard, Vancouver, ISO e altri

50

Wackerhage, Henning, Jonathon Smith e Darren Wisniewski. Molecular exercise physiology. A cura di Neil Armstrong e Willem van Mechelen. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198757672.003.0031.

Testo completo

Abstract (sommario):

Molecular exercise physiology is the study of exercise physiology using molecular biology methods. The development of differentiated cell types is regulated by transcription factors like the muscle-making MyoD that specifies cell type, while others regulate the development of muscle, tendons, and bones. Maternal nutrition and exercise commonly affect embryonic development through epigenetic mechanisms. Adaptation to exercise involves sensor proteins detecting exercise-related signals, the processing of signals by signalling proteins and networks, and the regulation of the actual adaptations by effector proteins. Many sport- and exercise-related traits depend on both common and rare DNA sequence variations, including the muscle mass-increasing myostatin (GDF8) loss-of-function and the haematocrit-increasing EPOR gain-of-function mutations. Additionally, common DNA sequence variations contribute to the inherited variability of development, body height, strength, and endurance. Finally, in addition to ethical concerns, current genetic performance tests only explain a fraction of the variation of sport and exercise-related traits.

Gli stili APA, Harvard, Vancouver, ISO e altri

Offriamo sconti su tutti i piani premium per gli autori le cui opere sono incluse in raccolte letterarie tematiche. Contattaci per ottenere un codice promozionale unico!