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Tesi sul tema "Skeletal Adaptation"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 13 febbraio 2022

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1

Ellman, Rachel. "Skeletal adaptation to reduced mechanical loading." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/107612.

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Thesis: Ph. D. in Medical Engineering and Bioastronautics, Harvard-MIT Program in Health Sciences and Technology, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 126-139).<br>Bone adapts its mass and architecture in response to its mechanical environment. Yet control of this process by mechanical cues is poorly understood, particularly for unloading. Defining the fundamental mechano-regulation of bone adaptation is critical for the better understanding and mitigation of bone loss in astronauts as well as clinical conditions such as spinal cord injur

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2

Eliman, Rachel. "Skeletal adaptation to reduced mechanical loading." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/95861.

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Thesis: Ph. D., Harvard-MIT Program in Health Sciences and Technology, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 126-139).<br>Bone adapts its mass and architecture in response to its mechanical environment. Yet control of this process by mechanical cues is poorly understood, particularly for unloading. Defining the fundamental mechanoregulation of bone adaptation is critical for the better understanding and mitigation of bone loss in astronauts as well as clinical conditions such as spinal cord injury, stroke, muscular dystrophy, and bed rest.

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3

Kohn, Tertius A. "Characteristics and adaptation of skeletal muscle to endurance exercise." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/16517.

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Thesis (PhD)--University of Stellenbosch, 2005.<br>ENGLISH ABSTRACT: Skeletal muscle adapts to stimuli by modifying structural and metabolic protein expression. Furthermore, a muscle group may vary within itself to accommodate specialisation in regions. Structural and metabolic characteristics of an individual are regulated partly by genotype, but contraction duration and intensity may play a greater role in muscle phenotype. The aims of this dissertation were to investigate: structural and metabolic regionalisation in a muscle group, possible relationships between training volume and int

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4

Beckitt, Timothy. "Skeletal muscle adaptation following a supervised exercise programme for claudication." Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539766.

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5

Wiebe, Peter N., and res cand@acu edu au. "Effects of Different Loading Intensities on Skeletal Adaptation to Exercise in Prepubertal Girls." Australian Catholic University. School of Exercise Science, 2004. http://dlibrary.acu.edu.au/digitaltheses/public/adt-acuvp62.29082005.

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This study involved a 28-week school-based exercise trial of single-leg drop-landing exercise with 42 girls (Tanner stage 1; 6-10 yr old) randomly assigned to control (C), low-drop (LD) or high-drop(HD) exercise groups. The latter two groups performed single-leg drop-landings (3 sessions.wk-1 and 50 landings.session-1) from 14cm and 28cm, respectively using the non-dominant leg. Single-leg peak ground-reaction impact forces (PGRIF) in a sub-sample ranged between 2.5 – 4.4 x body-weight (BW). No differences (p>0.05) among groups at baseline for age, stature, lean tissue mass (LTM - DXA - Lunar

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6

Hirschberg, Jens. "Simulations of mechanical adaptation and their relationship to stress bearing in skeletal tissue." University of Western Australia. School of Anatomy and Human Biology, 2005. http://theses.library.uwa.edu.au/adt-WU2005.0095.

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[Truncated abstract] In this work a computer simulation program, similar to a finite element program, is used to study the relationship between skeletal tissue structure and function. Though other factors affect the shape of bone (e.g., genetics, hormones, blood supply), the skeleton adapts its shape mainly in response to the mechanical environment to which it is exposed throughout life. The specific relationship between the mechanical environment and the mechanical adaptation response of the skeleton is reviewed. Theories of mechanical adaptation are applied to the sites of tendon attachment

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7

Chen, Ting. "LKB1 Regulation of High-Fat Diet-induced Adaptation in Mouse Skeletal Muscle." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6682.

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Ad libitum high-fat diet (HFD)-induced obesity leads to insulin resistance in skeletal muscle, altered gene expression, and altered growth signaling, all of which contributes to pathological changes in metabolism. Liver kinase B1 (LKB1) is an important metabolism regulator. The purpose of this dissertation was to understand how knocking out LKB1 influences HFD induced adaptations in mouse skeletal muscle. To do so, control and skeletal muscle LKB1 knock-out (LKB1-KO) mice were put on either standard diet (STD) or HFD for 1 week or 14 weeks, or put on the HFD for 14 weeks and then switched to S

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8

Isaacs, Ashwin Wayne. "Muscle damage and adaptation in response to plyometric jumping." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20384.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The aim of the study was to investigate skeletal muscle changes induced by an acute bout of plyometric exercise before and after plyometric training. The study consisted of an acute study and training intervention study. The acute study, investigated whether direct evidence of ultrastructural damage and identification of indirect factors were more evident in subjects presenting with rhabdomyolysis. Moreover the training intervention study investigated whether plyometric training would protect the muscle from ultrastructura

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9

Owino, Dorcas Vivian Apiyo. "Evaluation of role of paracrine/autocrine IGF-1 system in skeletal muscle adaptation." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406510.

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10

Varley, I. "Association of genotype with bone metabolism, skeletal adaptation and stress fracture injury occurrence." Thesis, Nottingham Trent University, 2014. http://irep.ntu.ac.uk/id/eprint/223/.

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Positive changes in bone metabolism, structural characteristics, size and mass are commonly associated with weight-bearing exercise. Despite this, negative effects of exercise on bone phenotypes, such as stress fracture injuries have been reported. Little is known about the extent of the genetic mediation of changes in bone characteristics, stress fracture injury and bone resorption in response to exercise. Accordingly, this thesis investigated: the genotype dependent changes in bone phenotypes in academy footballers before and after an increase in training volume; genetic associations with st

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11

Svensson, Michael B. "Endogenous antioxidants in human skeletal muscle and adaptation in energy metabolism : with reference to exercise-training, exercise-related factors and nutrition /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-433-X.

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12

Player, Darren James. "An in vitro model for assessment of skeletal muscle adaptation following exercise related physiological cues." Thesis, University of Bedfordshire, 2013. http://hdl.handle.net/10547/311732.

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The aim of this Thesis was to further characterise and utilise an in vitro skeletal muscle (SkM) model, to investigate its potential use in further understanding the cellular and molecular adaptations to exercise in vivo. Candidate genes and proteins have been identified using in vivo, ex vivo and targeted in vitro experiments, however the complete picture of these molecular mechanisms are far from understood. Furthermore, the extent to which mechanical signals contribute to the intra-cellular mechanisms associated with exercise is also underinvesitgated. To this end, developing an in vitro mo

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13

Rodden, Gregory Robert. "The Effects of Resistance Wheel Running on Skeletal Muscle Function and Adaptation in C57BL/10SnJ Mice." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/74274.

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Background: Resistance wheel running (RWR) can promote resistance-like training adaptations in mouse skeletal muscle (SkM), but its endurance-training effects are lesser known. Methods: Voluntary RWR was modulated as an exercise model to increase mouse hind-limb plantar-flexor torque and to promote endurance-training adaptations. Thirty male mice (cohort 1, n= 16; cohort 2, n= 14), were trained on a prototype RWR system that applied resistance relative to body mass (BM). Mice were sequentially, (1) screened for running ability (screening; 3-days); (2) trained with incremental adjustments to w

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14

Raue, Ulrika. "Effects of concentric vs eccentric resistance training on skeletal muscle adaptations in humans." Virtual Press, 2001. http://liblink.bsu.edu/uhtbin/catkey/1221284.

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The Beothuk Indians were an extinct group of Amerinds who were among the earliest founders of Newfoundland. In literature, the Beothuk were described as perhaps being phenotypically more similar to Europeans than Asians (Gatschet 1890, Lloyd 1875, 1876a, Marshall 1996). In this research, mitochondrial DNA (mtDNA) analysis was performed on a Beothuk individual in order to determine his haplotype and, perhaps, shed light on the origins of the Beothuk.For this analysis, a tooth of Nonosabasut, a Beothuk chief who died in 1819 was loaned from the Royal Museum of Scotland. Ancient DNA was extracted

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15

English, Tamara Erica Carleton University Dissertation Biology. "Enzymes of adenylate metabolism from the skeletal muscle of the hibernating prairie dog, Cynomys leucurus." Ottawa, 1995.

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16

Shields, Brenda Czerwinski. "Adaptive response of Japanese quail (Coturnix coturnix japonica) to cold-acclimation physiological changes and localization of avian UCP in skeletal muscle /." Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1564023381&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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17

Luitingh, Taryn Leigh. "Adaptation of the microbial decomposer community to the burial of skeletal muscle tissue in contrasting soils." University of Western Australia. Centre for Forensic Science, 2008. http://theses.library.uwa.edu.au/adt-WU2009.0037.

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Microorganisms are known to be agents involved in the decomposition of organic matter. However, little is known about the participation of the microbial communities during the decomposition of mammalian skeletal muscle tissue. This study investigates the capacity of the soil microbial community to adapt to the decomposition of skeletal muscle tissue in differing soils. This has implications for the study of mass graves and sites of repeated burial. A controlled laboratory experiment was designed to assess the adaptability of microbial communities present in three distinct soil types (sand, loa

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18

Davidsen, Peter Kåre. "Understanding skeletal muscle adaptation in health and chronic disease : a multi-omics based systems biology perspective." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6563/.

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Mammalian skeletal muscle has a major impact on whole-body metabolic homeostasis. Hence, maintenance of a metabolically active muscle mass is key for optimal health. Notably, both muscle function and mass are profoundly negatively affected by environmental factors such as chronic smoking and physical inactivity. RNA abundance integrates genetic, epigenetic and environmental influences. Therefore, while true understanding of physiological adaptation likely require the integration between multi-level datasets, the transcriptome represents a powerful investigative tool in determining the underlyi

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19

Sorensen, Jacob R. "Repair and Adaptation of Aged Skeletal Muscle to Nonpathological Muscle Damage: The Influence of Macrophage Polarization." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7691.

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The age-related loss of skeletal muscle mass and function is accompanied by a decline in regenerative capacity. The processes that facilitate healthy muscle repair are complex, involving several phases of degradation and rebuilding of muscle tissue and the surrounding microenvironment. Specifically, myogenic progenitor cells known as satellite cells are the most influential in repairing damaged muscle tissue. Following injury, satellite cells become activated and migrate, proliferate and fuse with mature skeletal muscle fibers to restore homeostasis to the tissue. However, satellite cells do n

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20

Siew, Yun Ysi. "The impacts of climate and the environment on human skeletal morphology during the Holocene in north China." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267070.

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This dissertation investigates the temporal and regional variation in human skeletal morphology in relation to climate and the environment in Holocene China. Linking skeletal morphology to the changes in climate, subsistence strategy and socio-political development has been well-documented in various geographical areas. Although a general pattern has been observed among different populations, it is evident that local factors have played an equally important role in human morphological variation. China was chosen in this dissertation because its diverse geographical, historical and cultural bac

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21

Harvey, Mordecai Micah. "Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78235.

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The prevalence of obesity and type II diabetes is increasing. Although exercise is widely accepted for prevention and treatment, evidence of resistance to exercise in patients with these diseases is also mounting. Muscle contraction during exercise stimulate cellular responses important for adaptation. These responses include the release of myokines and the subsequent increase in substrate metabolism. This study aimed to define a culture model for simulating exercise in human primary skeletal muscle cells. We hypothesized that chronic electric pulse stimulation (EPS) of human myotubes in vi

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22

Ali, Mostafa M. "The Role of Toll Like Receptor-4 in Exercise-induced Myokine Response and Regulation of Skeletal Muscle Metabolic Adaptation." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/84870.

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Toll like receptor-4 (TLR4) is a transmembrane inflammatory receptor expressed ubiquitously on the cell surface of immune cells as well as skeletal muscle and other metabolic tissues. A compelling body of evidence shows that muscle TLR4 and the downstream cytokine signaling modulate skeletal muscle metabolism. Intriguingly, skeletal muscle has been demonstrated to gain favorable inflammatory cytokine-mediated metabolic adaptations in the context of exercise training. This paradigm suggests a role for muscle TLR4 inflammatory signaling in the regulation of exercise metabolism. As such, the que

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23

Zheng, Wenya [Verfasser]. "Impacts of isoflavones and physical activity on skeletal muscle anabolic adaptation and fatty acid metabolism / Wenya Zheng." Köln : Zentralbibliothek der Deutschen Sporthochschule, 2017. http://d-nb.info/1151513717/34.

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24

Yu, Fushun. "Adaptability of skeletal muscle to hormone treatment in relation to gender and aging /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3585-8/.

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25

Swisher, Anne K. "The effect of emphysema on adaptation of peripheral skeletal muscle to different loading conditions in the Syrian golden hamster." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3008.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains vii, 141 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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26

Januševičius, Donatas. "Skirtingos griaučių raumenų adaptacijos įtaka galingumui." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130910_154834-73898.

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Galingumas yra ryšys tarp jėgos ir greičio. Galingumo ugdymo pratimai skirti skatinti neuroraumenų sistemą, kad per trumpą laiko tarpą raumuo spėtų išsitempti (ekscentrinis susitraukimas) ir susitraukti (koncentrinis susitraukimas) (Foran, Pound, 2007). Galingumui reikalinga maksimalioji jėga ir didelis judesio greitis (Табачник, 1988; Matthew et al., 2011). Wilson G.J. su bendraautoriais (1993) nustatė, kad galingumas po jėgos treniruočių pagerėjo 5 %; po pliometrijos treniruočių – 10 %; po balistinių (greitumo jėgos) pratimų – 18 %. Tiriant tokias sporto šakas kaip krepšinis ir tinklinis buv

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27

Alligood, Kristin. "Using Natural Populations of Threespine Stickleback to Identify the Genomic Basis of Skeletal Variation." Thesis, University of Oregon, 2017. http://hdl.handle.net/1794/22781.

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Across vertebrates, skeletal shapes are diverse, and much of this variation appears to be adaptive. In contrast, the early developmental programs of these structures are highly conserved across vertebrates. The question then becomes where in the conserved genetic programs of skeletal development does variation lie to direct diversity? In threespine stickleback, rapid changes in head and body shape have been documented during repeated and independent invasions of oceanic fish into freshwater habitats in regions deglaciated approximately 13,000 years ago. However, recent research indicates that

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Myllymäki, M. (Mikko). "Hypoxia-inducible factor prolyl 4-hydroxylase-2 in Tibetan high-altitude adaptation, extramedullary erythropoiesis and skeletal muscle ischemia." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212210.

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Abstract Adequate oxygen supply is necessary for aerobic cell survival. Cellular oxygen deprivation, also known as hypoxia, leads to various responses that aim to increase cellular oxygen delivery and reduce oxygen consumption. Oxygen homeostasis is mainly regulated by the hypoxia-inducible factor (HIF), which regulates the expression of over 300 genes in response to hypoxia. The stability of HIF is regulated by the HIF prolyl 4-hydroxylases (HIF-P4Hs), enzymes that catalyze the hydroxylation of proline residues in HIFα subunits and target them towards proteasomal degradation. HIF-P4Hs require

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29

Norrbrand, Lena. "Acute and early chronic responses to resistance exercise using flywheel or weights." Stockholm : Department of Physiology and Pharmacology, Karolinska Institutet, 2008. http://diss.kib.ki.se/2008/978-91-7409-030-7/.

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30

Masuda, Shinya. "Adaptation of cytoskeletal and sarcolemmal proteins for functional requirements － new information for the development of fatigue resistance in skeletal muscle －." Kyoto University, 2009. http://hdl.handle.net/2433/123932.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第14717号<br>人博第453号<br>新制||人||111(附属図書館)<br>20||人博||453(吉田南総合図書館)<br>UT51-2009-D429<br>京都大学大学院人間・環境学研究科共生人間学専攻<br>(主査)准教授林達也, 教授森谷敏夫, 教授小田伸午, 教授田口貞善<br>学位規則第4条第1項該当

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31

Terpstra, Brian T. "Age and gender related differences in skeletal muscle adaptations to twelve weeks of progressive resistance training." Virtual Press, 2001. http://liblink.bsu.edu/uhtbin/catkey/1217387.

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Diabetic patients are prone to complications and need foot care education. The purposes of this study were to (1) examine the effectiveness of instruction on knowledge of foot care in diabetics, and practice of foot care in diabetics, and (2) examine the relationship between health promoting behaviors and foot care practices. The theoretical framework for this study was Nola Pender's Health Promotion Model. The sample for the study consisted of 69 individuals, ages 18 and older with diabetes mellitus (Type I or Type II).Control and experimental groups completed a demographic sheet and Pender's

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Ferrari, Andrea Lepos. "Adaptação transcultural do questionário \"cultural study of musculo-skeletal and other symptoms and associated disability\" CUPID Questionnaire." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/7/7131/tde-07072009-094358/.

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Este estudo objetivou a adaptação transcultural do questionário Cultural Study of Musculo-Skeletal and Other Symptoms and Associated Disability - CUPID Questionnaire, para a língua portuguesa falada no Brasil e a validação do seu conteúdo. O estudo é do tipo metodológico e foi realizado obedecendo aos procedimentos internacionais recomendados e aos procedimentos específicos indicados pelo autor do Questionário, uma vez que será aplicado em estudo multicêntrico por ele coordenado. A adaptação transcultural foi realizada seguindo as etapas de tradução, retrotradução, avaliação destas versões por

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33

Feldman, Chris R. "Evolutionary Genetics of Tetrodotoxin (TTX) Resistance in Snakes: Tracking a Feeding Adaptation from Populations Through Clades." DigitalCommons@USU, 2008. https://digitalcommons.usu.edu/etd/159.

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Understanding the nature of adaptive evolution has been the recent focus of research detailing the genetic basis of adaptation and theoretical work describing the mechanics of adaptive evolution. Nevertheless, key questions regarding the process of adaptive evolution remain. Ultimately, a detailed description of the ecological context, evolutionary history, and genetic basis of adaptations is required to advance our understanding of adaptive evolution. To address some of the contemporary issues surrounding adaptive evolution, I examine phenotypic and genotypic changes in a snake feeding ada

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34

Caldas, de Almeida Araujo Ericky. "Adaptation of Proof of Concepts Into Quantitative NMR Methods : Clinical Application for the Characterization of Alterations Observed in the Skeletal Muscle Tissue in Neuromuscular Disorders." Phd thesis, Université Paris Sud - Paris XI, 2014. http://tel.archives-ouvertes.fr/tel-01067940.

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Current quantitative nuclear magnetic resonance (NMR) technics offer biomarkers that allow performing non-invasive longitudinal studies for the follow up of therapeutic trials in neuromuscular disorders (NMD). In contrast to fat degeneration, the mechanisms of inflammation/oedema/necrosis and fibrosis are characteristic signs of disease activity, which makes their quantification a promising source of crucial biomarkers for longitudinal studies. This thesis work consisted on the implementation of more precise quantitative NMR methods adapted to the clinical study of skeletal muscle (SKM) for :

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Araujo, Ericky Caldas de Almeida. "Adaptation of Proof of Concepts Into Quantitative NMR Methods : Clinical Application for the Characterization of Alterations Observed in the Skeletal Muscle Tissue in Neuromuscular Disorders." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112075/document.

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Actuellement, des méthodes quantitatives de résonance magnétique nucléaire (RMN) offrent des biomarqueurs qui permettent la réalisation d’études longitudinales pour le suivi de l’évolution des maladies neuromusculaires et des essais thérapeutiques de manière non-invasive. A la différence de la dégénérescence graisseuse, les processus d’inflammation/œdème/nécrose et fibrose sont des signes d’activité des maladies et leurs quantifications constitueraient ainsi de biomarqueurs parfaitement adaptés pour le suivi thérapeutique. Ce travail de thèse a consisté à mettre en place des méthodologies quan

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Miller, Vincent J. "The effect of a ketogenic diet on mitochondria function in human skeletal muscle during adaptation to chronic exercise training and the potential involvement of metabolic dysregulation." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1554558461682203.

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Ferrucci, Danilo Lopes 1982. "Efeito do exercicio incremental exaustivo nas metaloproteinases 2 e 9 no musculo gastrocnemio de ratos Wistar." [s.n.], 2018. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314734.

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Orientadores: Denise Vaz de Macedo, Dagmar Ruth Stach-Machado<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-15T21:15:50Z (GMT). No. of bitstreams: 1 Ferrucci_DaniloLopes_M.pdf: 1810214 bytes, checksum: 4728c1ea4c33f76583148c1588199a23 (MD5) Previous issue date: 2018-08-15T18:15:37Z<br>Resumo: Os músculos esqueléticos são constituídos por fibras musculares e pela matriz extracelular. Em resposta ao exercício, o músculo apresenta a habilidade de transformar o estresse mecânico da contração muscular em adaptações de c

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Otis, Jeffrey Scott. "Skeletal muscle adaptations in cachectic, tumor-bearing rats." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/26673.

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Cancer cachexia is a debilitating, paraneoplastic syndrome commonly associated with late stage malignancy. It is estimated that ~25% of cancer-related deaths are due directly to complications arising from cachexia (Barton, 2001). Cachexia manifests as severe body wasting, primarily due to the loss of skeletal muscle mass. This study tested the hypothesis that muscle atrophy associated with cancer cachexia could be attenuated by using a unilateral, functional overload (FO) model applied concurrently with tumor development. To accomplish this, Morris hepatoma MH-7777 cells were implanted

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Pathare, Neeti C. "Metabolic adaptations following disuse and their impact on skeletal muscle function." [Gainesville, Fla.] : University of Florida, 2005. http://purl.fcla.edu/fcla/etd/UFE0010024.

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Thesis (Ph.D.)--University of Florida, 2005.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 171 pages. Includes Vita. Includes bibliographical references.

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O'Keefe, Matthew Phillip. "Adaptations of skeletal muscle insulin signaling following hindlimb suspension." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280440.

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Hindlimb suspension (HS) in rats was used to study the effects of simulated microgravity on whole-body glucose tolerance and soleus muscle insulin signaling. Following short-term HS (1-day), glucose intolerance and whole-body insulin resistance developed. Insulin resistance was also identified at the skeletal muscle level, with the type I soleus showing more insulin resistance than the type II extensor digitorum longus (EDL). Examination of insulin signaling components in the soleus revealed a tendency towards a decrease in the expression of the p85 regulatory subunit of phosphatidylinositol-3

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Singh, François. "Skeletal muscle toxicity and statins : role of mitochondrial adaptations." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ050/document.

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Bien que les statines forment la classe d'hypolipidémiants la plus utilisée, une toxicité musculaire a été reportée, pouvant ainsi provoquer l’apparition d’une myopathie. Dans la première partie, nous avons montré chez l’Homme et l’animal que les statines inhibent directement la chaine respiratoire mitochondriale, et induisent la production de radicaux libres dérivés de l’oxygène (RLO), qui active les voies apoptotiques dans les muscles glycolytiques, alors que les muscles oxydatifs ne sont pas atteints. Nous avons ensuite montré in vitro que le stress réducteur peut engendrer une oxydation mi

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42

Rafati, Nima. "Exploring genetic diversity in natural and domestic populations through next generation sequencing." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-315032.

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Studying genetic diversity in natural and domestic populations is of major importance in evolutionary biology. The recent advent of next generation sequencing (NGS) technologies has dramatically changed the scope of these studies, enabling researchers to study genetic diversity in a whole-genome context. This thesis details examples of studies using NGS data to: (i) characterize evolutionary forces shaping the genome of the Atlantic herring, (ii) detect the genetic basis of speciation and domestication in the rabbit, and, (iii) identify mutations associated with skeletal atavism in Shetland po

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Bowser, Suzanne Mae. "Skeletal muscle metabolic adaptations in response to an acute high fat diet." Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/82030.

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Macronutrient metabolism plays an essential role in the overall health of an individual. Depending on a number of variables, for example, diet, fitness level, or metabolic disease state, protein, carbohydrate and fat have varying capacities to be oxidized and balanced. Further, when analyzing the oxidation of carbohydrate and fat in the skeletal muscle specifically, carbohydrate balance happens quite rapidly, while fat balance does not. The ability of skeletal muscle to adapt and respond to various nutrient states is critical to maintaining healthy metabolic function. Habitual high fat intake

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Lundberg, Tommy. "The Effects of Aerobic Exercise on Human Skeletal Muscle Adaptations to Resistance Exercise." Doctoral thesis, Mittuniversitetet, Avdelningen för hälsovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-21917.

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Aerobic exercise (AE) may interfere with muscle adaptations induced by resistance exercise (RE). Three experimental campaigns were conducted to explore the influence of AE on molecular, functional and muscular adaptations to acute and chronic RE. Twenty-nine men performed unilateral knee extensor RE preceded by AE (AE+RE). The contralateral leg did RE only. First, the influence of acute AE on muscle molecular responses to RE performed 6 h later was studied. Subsequently, this exercise regimen was implemented over 5 weeks training. The relationships between acute and chronic outcomes were exami

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Mattern, Craig O. "MAXIMAL LACTATE STEADY STATE: INFLUENCE OF THE AGE-RELATED ADAPTATIONS OF SKELETAL MUSCLE." Connect to this title online, 2002. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1039034888.

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Thesis (Ph. D.)--Ohio State University, 2002.<br>Title from first page of PDF file. Document formatted into pages; contains xii, 49 p.; also includes graphics (some col.) Includes bibliographical references (p. 39-44). Available online via OhioLINK's ETD Center

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Carroll, Kevin M., Caleb D. Bazyler, Jake R. Bernards, et al. "Skeletal Muscle Fiber Adaptations Following Resistance Training Using Repetition Maximums or Relative Intensity." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/5786.

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The purpose of the study was to compare the physiological responses of skeletal muscle to a resistance training (RT) program using repetition maximum (RM) or relative intensity (RISR). Fifteen well-trained males underwent RT 3 d·wk−1 for 10 weeks in either an RM group (n = 8) or RISR group (n = 7). The RM group achieved a relative maximum each day, while the RISR group trained based on percentages. The RM group exercised until muscular failure on each exercise, while the RISR group did not reach muscular failure throughout the intervention. Percutaneous needle biopsies of the vastus lateralis

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Toma, Kumika. "Effects of High-Carbohydrate and Low-Fat Versus High-Protein and Low-Carbohydrate Diets on High-Intensity Aerobic Exercise." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3372362.

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Slater, Graham James. "Biomechanical adaptations to predation in the carnivoran craniofacial skeleton." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1997615301&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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49

Kirby, Tyler. "GLOBAL-SCALE ANALYSIS OF THE DYNAMIC TRANSCRIPTIONAL ADAPTATIONS WITHIN SKELETAL MUSCLE DURING HYPERTROPHIC GROWTH." UKnowledge, 2015. http://uknowledge.uky.edu/physiology_etds/22.

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Skeletal muscle possesses remarkable plasticity in responses to altered mechanical load. An established murine model used to increase mechanical load on a muscle is the surgical removal of the gastrocnemius and soleus muscles, thereby placing a functional overload on the plantaris muscle. As a consequence, there is hypertrophic growth of the plantaris muscle. We used this model to study the molecular mechanisms regulating skeletal muscle hypertrophy. Aged skeletal muscle demonstrates blunted hypertrophic growth in response to functional overload. We hypothesized that an alteration in gene expr

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50

Williamson, David L. "Effects of progressive resistance training on skeletal muscle protein isoform adaptations in elderly men." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1136712.

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Progressive resistance training (PRT) in the elderly has commonly used ATPase histochemistry to evaluate fiber type changes, but evidence shows there are myosin heavy chain (MHC) hybrids in aging muscle that cannot be classified by histochemistry. The purpose of this study was to assess the MHC and whole muscle alterations following a 12-week PRT protocol. Seven healthy men (age=74.0±4.7, weight=74.6±13.5kg) underwent testing for 1-repetition maximum (1-RM), whole muscle (thigh) crosssectional area (CSA) by computed tomography, and a needle muscle biopsy from the vastus lateralis for analysis

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