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Articoli di riviste sul tema "Skin Barrier Repair"

Autore: Grafiati

Pubblicato: 7 giugno 2025

Ultima modifica: 2 agosto 2025

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1

Yang, Jieyi, Jiageng Guo, Peiling Tang, et al. "Insights from Traditional Chinese Medicine for Restoring Skin Barrier Functions." Pharmaceuticals 17, no. 9 (2024): 1176. http://dx.doi.org/10.3390/ph17091176.

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The skin barrier is essential for maintaining the body’s internal homeostasis, protecting against harmful external substances, and regulating water and electrolyte balance. Traditional Chinese Medicine (TCM) offers notable advantages in restoring skin barrier function due to its diverse components, targets, and pathways. Recent studies have demonstrated that active ingredients in TCM can safely and effectively repair damaged skin barriers, reinstating their proper functions. This review article provides a comprehensive overview of the mechanisms underlying skin barrier damage and explores how

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Ionescu, Marius-Anton Anton. "Skin barrier: structure and immune changes in common skin diseases." Russian Journal of Allergy 11, no. 2 (2014): 83–89. http://dx.doi.org/10.36691/rja549.

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Skin barrier must be seen as a complex structure with complex functions involving hydrolipidic film, stratum corneum, the intercellular cement and also immunologic barrier as innate adaptive immune system (as Toll Like Receptors - TLR), complement, dendritic cells and antigen-related responses. Skin barrier changes are seen in different skin diseases as atopic dermatitis, rosacea , contact dermatitis and others. In the first part of this article we describe skin physical barrier and its key elements roles (ceramides, filaggrin, tight junctions and claudins), the clinical consequences of barrie

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Nguyen, Hai Le Thanh, Juan Valentin Trujillo-Paez, Yoshie Umehara, et al. "Role of Antimicrobial Peptides in Skin Barrier Repair in Individuals with Atopic Dermatitis." International Journal of Molecular Sciences 21, no. 20 (2020): 7607. http://dx.doi.org/10.3390/ijms21207607.

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Atopic dermatitis (AD) is a common chronic inflammatory skin disease that exhibits a complex interplay of skin barrier disruption and immune dysregulation. Patients with AD are susceptible to cutaneous infections that may progress to complications, including staphylococcal septicemia. Although most studies have focused on filaggrin mutations, the physical barrier and antimicrobial barrier also play critical roles in the pathogenesis of AD. Within the physical barrier, the stratum corneum and tight junctions play the most important roles. The tight junction barrier is involved in the pathogenes

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4

BOSCHERT, SHERRY. "Repair Skin Barrier in Treating Hand Dermatitis." Internal Medicine News 43, no. 3 (2010): 33. http://dx.doi.org/10.1016/s1097-8690(10)70156-6.

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5

Rawlings, A. V., P. J. Matts, C. D. Anderson, and M. S. Roberts. "Skin biology, xerosis, barrier repair and measurement." Drug Discovery Today: Disease Mechanisms 5, no. 2 (2008): e127-e136. http://dx.doi.org/10.1016/j.ddmec.2008.03.001.

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6

MCNAMARA, DAMIAN. "Atopic Dermatitis Tamed By Repair of Skin Barrier." Family Practice News 36, no. 22 (2006): 33. http://dx.doi.org/10.1016/s0300-7073(06)74188-3.

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7

Draelos, Zoe Diana. "New treatments for restoring impaired epidermal barrier permeability: Skin barrier repair creams." Clinics in Dermatology 30, no. 3 (2012): 345–48. http://dx.doi.org/10.1016/j.clindermatol.2011.08.018.

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8

Zhu, Xiaoxuan, Wenlu Yuan, Zhuozheng Li, et al. "Progress of Research on Antioxidants and Carriers for Skin Wound Repair." Processes 11, no. 7 (2023): 2069. http://dx.doi.org/10.3390/pr11072069.

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The skin is the first protective barrier of the human body, and oxidative damage is one of the main mechanisms of skin injury. Effective antioxidant therapy plays an important role in skin healing. Therefore, exploring antioxidants and suitable drug delivery methods that can be used for skin injury repair is of great value in regulating skin repair and regeneration and promoting wound healing. Based on this, this paper presents a review of the progress of research on (1) antioxidants and (2) antioxidant carriers for skin repair in order to summarize the research results and provide reference f

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9

Danso, Mogbekeloluwa O., Tineke Berkers, Arnout Mieremet, Farzia Hausil, and Joke A. Bouwstra. "Anex vivo humanskin model for studying skin barrier repair." Experimental Dermatology 24, no. 1 (2014): 48–54. http://dx.doi.org/10.1111/exd.12579.

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10

Elias, Peter M., and Jeffrey Sugarman. "Does moisturizing the skin equate with barrier repair therapy?" Annals of Allergy, Asthma & Immunology 121, no. 6 (2018): 653–56. http://dx.doi.org/10.1016/j.anai.2018.07.008.

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11

Cannon, Alice, Holly Wilkinson, Michelle Rudden, and Mat Hardman. "P18 Investigating the role of the microbiome in chronic wound skin barrier reformation." British Journal of Dermatology 190, no. 6 (2024): e87-e87. http://dx.doi.org/10.1093/bjd/ljae105.040.

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Abstract Introduction and aims The integrity of the skin barrier plays a pivotal role in dermatological health, particularly in elderly and individuals with diabetes who are more susceptible to injury. Our skin barrier is also in direct contact with the microbiota, a diverse community of microorganisms that play wide-ranging roles in cutaneous function. Although microbial dysbiosis has been observed in elderly and diabetic skin, few studies have investigated the mechanistic links between skin barrier perturbations and the microbiome. The aim of this study was to compare barrier reformation in

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12

Peng, Ge, Saya Tsukamoto, Yoshie Umehara, et al. "Experimental and Clinical Evidence Suggests That Treatment with Betacellulin Can Alleviate Th2-Type Cytokine-Mediated Impairment of Skin Barrier Function." International Journal of Molecular Sciences 23, no. 19 (2022): 11520. http://dx.doi.org/10.3390/ijms231911520.

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Betacellulin (BTC) is a peptide ligand that belongs to the epidermal growth factor family, the members of which have been implicated in skin morphogenesis, homeostasis, repair, and angiogenesis; however, the role of BTC in the regulation of the skin barrier remains unknown. To examine the role of BTC in skin barrier function, we analyzed atopic dermatitis (AD) transcriptomic data from Gene Expression Omnibus (GEO) datasets, performed BTC immunohistochemistry using human skin tissues, and evaluated the effects of BTC on primary human keratinocytes by real-time PCR, Western blotting, and assay o

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13

Schild, Jennifer, Aneta Kalvodová, Jarmila Zbytovská, Mike Farwick, and Cornelia Pyko. "The role of ceramides in skin barrier function and the importance of their correct formulation for skincare applications." International Journal of Cosmetic Science 46, no. 4 (2024): 526–43. http://dx.doi.org/10.1111/ics.12972.

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AbstractCeramides are a family of lipids constituted by a sphingoid base and a fatty acid. In the skin, they are mainly present in the stratum corneum where, with cholesterol and free fatty acids, they constitute the inter‐corneocyte lipids. With the other lipid groups, they play a key role in the formation of dense lamellar structures between adjacent corneocytes, collectively ensuring the vital efficient barrier to water evaporation and protection from foreign agents´ penetration. Changes in ceramide level and relative composition, with potential impairment of lipid arrangement, have been ev

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14

Zhou, Yu, Lichun Wu, Yi Zhang, et al. "Topical Delivery of Ceramide by Oil-in-Water Nanoemulsion to Retain Epidermal Moisture Content in Dermatitis." Biomolecules 15, no. 5 (2025): 608. https://doi.org/10.3390/biom15050608.

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External environmental stressors and internal physiological changes frequently compromise the skin barrier, resulting in conditions such as dermatitis and dehydration. A key underlying factor is the depletion of ceramides, essential lipids in the stratum corneum that maintain skin integrity. Although topical ceramide supplementation is effective for barrier repair, its clinical application is limited by poor solubility and low skin permeability. To overcome these challenges, this study developed an oil-in-water nanoemulsion (O/W-NE) using ultrasonic emulsification for the efficient transdermal

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Kirchner, Stephen, Vivian Lei, and Amanda S. MacLeod. "The Cutaneous Wound Innate Immunological Microenvironment." International Journal of Molecular Sciences 21, no. 22 (2020): 8748. http://dx.doi.org/10.3390/ijms21228748.

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The skin represents the first line of defense and innate immune protection against pathogens. Skin normally provides a physical barrier to prevent infection by pathogens; however, wounds, microinjuries, and minor barrier impediments can present open avenues for invasion through the skin. Accordingly, wound repair and protection from invading pathogens are essential processes in successful skin barrier regeneration. To repair and protect wounds, skin promotes the development of a specific and complex immunological microenvironment within and surrounding the disrupted tissue. This immune microen

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16

Berkers, T., W. A. Boiten, S. Absalah, J. van Smeden, A. P. M. Lavrijsen, and J. A. Bouwstra. "Compromising human skin in vivo and ex vivo to study skin barrier repair." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864, no. 8 (2019): 1103–8. http://dx.doi.org/10.1016/j.bbalip.2019.04.005.

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17

Zhang, Z., M. Lukic, S. Savic, and D. J. Lunter. "Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin." International Journal of Cosmetic Science 40, no. 5 (2018): 494–501. http://dx.doi.org/10.1111/ics.12491.

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18

Welzel, J., K. P. Wilhelm, and H. H. Wolff. "Skin permeability barrier and occlusion: no delay of repair in irritated human skin *." Contact Dermatitis 35, no. 3 (1996): 163–68. http://dx.doi.org/10.1111/j.1600-0536.1996.tb02335.x.

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19

International, Journal of Medical Science and Innovative Research (IJMSIR). "Assessing Techniques for Creating Skin Damage and Evaluating Wound Healing: Significance for Skincare and Clinical Application." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 2 (2024): 77–87. https://doi.org/10.5281/zenodo.15378643.

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<strong>Abstract</strong> <strong>Background:</strong> Skin, our body's crucial barrier, faces threats and requires maintenance. Controlled skin damage induced by Sodium Lauryl Sulphate (SLS) and tape-stripping provide insights into wound creation processes. Parameters like skin hydration, topography and inflammation are vital indicators. This study validates methods for wound creation / damaging skin and evaluates product effectiveness to enhance skin health interventions. <strong>Methods:</strong> The study adhered to ethical guidelines, receiving approval from ethics committee, and followed

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20

BOSCHERT, SHERRY. "Hand Dermatitis Treatment Should Involve Repair of the Skin Barrier." Family Practice News 39, no. 21 (2009): 39. http://dx.doi.org/10.1016/s0300-7073(10)70199-7.

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21

Essa, Ebtessam A., Michael C. Bonner, and Brian W. Barry. "Electroporation and ultradeformable liposomes; human skin barrier repair by phospholipid." Journal of Controlled Release 92, no. 1-2 (2003): 163–72. http://dx.doi.org/10.1016/s0168-3659(03)00326-2.

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22

Thomas, Richard, Ian Landells, Charles Lynde, et al. "Canadian Consensus on Skin Barrier Repair Therapy in Atopic Dermatitis." Journal of Cutaneous Medicine and Surgery 16, no. 1_suppl (2012): S1—S15. http://dx.doi.org/10.2310/7750.2012.s1pedia.

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23

Shen, Yixin, Ying Ye, Lina Wang, et al. "Study of the Repair Action and Mechanisms of a Moisturizing Cream on an SLS-Damaged Skin Model Using Two-Photon Microscopy." Cosmetics 12, no. 3 (2025): 119. https://doi.org/10.3390/cosmetics12030119.

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This study evaluates the efficacy of a novel moisturizing cream using a sodium lauryl sulfate (SLS)-induced skin damage model, supported by advanced imaging with two-photon microscopy (TPM). TPM’s capabilities allow for in-depth, non-invasive visualization of skin repair processes, surpassing traditional imaging methods. The innovative formulation of the cream includes ceramide NP, ceramide NS, ceramide AP, lactobacillus/soybean ferment extract, and bacillus ferment, targeting the enhancement of skin hydration, barrier function, and structural integrity. In SLS-stimulated 3D skin models and cl

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24

Yadav, Nidhi, Bhushan Madke, and Anupam Das. "Ceramides: Where do we stand?" Cosmoderma 1 (September 15, 2021): 44. http://dx.doi.org/10.25259/csdm_33_2021.

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Ceramides are an integral component of the epidermal barrier system. Alterations in ceramides levels are associated with various inflammatory dermatoses such as psoriasis, atopic dermatitis, ichthyosis, Gaucher’s disease, acne vulgaris, and skin aging. Various formulations containing ceramides have been developed so that exogenous ceramides can repair the barrier function. Herein, the authors have provided an overview of the basic anatomy, structure, functioning, and importance of ceramides and their role in healthy skin and various skin disorders. In addition, the authors review conventional

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25

Fujii, Masanori. "The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis." Cells 10, no. 9 (2021): 2386. http://dx.doi.org/10.3390/cells10092386.

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Ceramides play an essential role in forming a permeability barrier in the skin. Atopic dermatitis (AD) is a common chronic skin disease associated with skin barrier dysfunction and immunological abnormalities. In patients with AD, the amount and composition of ceramides in the stratum corneum are altered. This suggests that ceramide abnormalities are involved in the pathogenesis of AD. The mechanism underlying lipid abnormalities in AD has not yet been fully elucidated, but the involvement of Th2 and Th1 cytokines is implicated. Ceramide-dominant emollients have beneficial effects on skin barr

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26

Maarouf, Melody, Bryan Kromenacker, Eric Brucks, and Vivian Shi. "Expedited Resolution of 5-Fluorouracil-Induced Erythema and Barrier Dysfunction with White Petrolatum." SKIN The Journal of Cutaneous Medicine 3, no. 4 (2019): 279–82. http://dx.doi.org/10.25251/skin.3.4.9.

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Actinic keratoses (AK) are precancerous lesions that develop on chronically sun-exposed skin. They frequently require prophylactic field treatment due to the risk of progression to squamous cell carcinoma. Topical treatment with 5-fluorouracil (5-FU) yields near complete AK resolution, yet leaves a patient with an exuberant erythematous treatment site, which may be embarrassing and/or uncomfortable. We report a case of a patient with diffuse facial AK who was treated with 5-FU twice daily for 2 weeks, resulting in fiery-red erythema and disrupted barrier indices. Application of pure ultra whit

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Smolnikov, E. V., A. O. Litovkina, O. G. Elisyutina, and E. S. Fedenko. "Clinical efficacy of modern emollients in atopic dermatitis: case report." Russian Journal of Allergy 15, no. 4 (2018): 76–82. http://dx.doi.org/10.36691/rja139.

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Atopic dermatitis is the common chronic inflammatory disorder, characterized by skin irritation, itch, often accompanied by respiratory allergy symptoms - allergic rhinitis and bronchial asthma. AD prevalence varies between 15-30% in children and 2-14% in adults in industrialized countries. The pathophysiology of atopic dermatitis is complex encompassing genetic predisposition to allergy, dysregulation of innate and adaptive immunity and environmental risk factors. Recent genetic and molecular research has focused interest on skin barrier function and it’s role in AD pathogenesis. It has been

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Nip, John, Hilal Ilarslan, Ana Villa, et al. "Topically applied, fatty acid‐containing formulations provide superior barrier benefits in an ex vivo tape‐stripped skin model." International Journal of Cosmetic Science 46, no. 4 (2024): 506–15. http://dx.doi.org/10.1111/ics.12961.

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AbstractObjectiveEx vivo skin has been used to study various skin conditions from atopic dermatitis to burn injury. The aim of this research is to identify a more effective barrier improvement strategy and to evaluate topical formulations in replenishing the skin. The skin can create new longer chain fatty acids and ceramides (CERs) from topically applied skin natural fatty acid to help renew the skin's barrier.MethodsAn ex vivo skin model damaged by sequential tape stripping of the stratum corneum (SC) was used to investigate the repair of the SC. Confocal laser scanning microscopy was used t

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Valdman-Grinshpoun, Y., D. Ben-Amitai, and A. Zvulunov. "Barrier-Restoring Therapies in Atopic Dermatitis: Current Approaches and Future Perspectives." Dermatology Research and Practice 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/923134.

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Atopic dermatitis is a multifactorial, chronic relapsing, inflammatory disease, characterized by xerosis, eczematous lesions, and pruritus. The latter usually leads to an “itch-scratch” cycle that may compromise the epidermal barrier. Skin barrier abnormalities in atopic dermatitis may result from mutations in the gene encoding for filaggrin, which plays an important role in the formation of cornified cytosol. Barrier abnormalities render the skin more permeable to irritants, allergens, and microorganisms. Treatment of atopic dermatitis must be directed to control the itching, suppress the inf

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Liu, Ziyang, Dengjun Qiu, Tong Yang, et al. "Research Progress of Dihydroquercetin in the Treatment of Skin Diseases." Molecules 28, no. 19 (2023): 6989. http://dx.doi.org/10.3390/molecules28196989.

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Skin is a barrier to maintaining the stability of the human environment and preventing the invasion of pathogens. When skin tissue is exposed to the external environment, it will inevitably develop defects due to trauma, injury, burns, ulcers, surgery, and chronic diseases. Rapid skin repair is the key to reducing infection, relieving pain, and improving quality of life. Dihydroquercetin is a kind of flavonoid that has a wide range of pharmacological activities and can improve skin repair, skin inflammation, skin cancer, and so on. In this paper, the application of dihydroquercetin in medical

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31

Lu, Wangwang, Dan Luo, Dan Chen, et al. "Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy." Molecules 28, no. 13 (2023): 5275. http://dx.doi.org/10.3390/molecules28135275.

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Sensitive skin is defined as skin with low tolerance and high reactivity. Natural products, such as paeoniflorin and madecassoside, have unique skin care functionality. However, because they are hampered by the skin barrier, paeoniflorin and madecassoside have difficulty penetrating the stratum corneum, resulting in weakened skin barrier repair and anti-inflammatory effects. In addition, there is a lack of detailed studies on the efficacy of paeonol and madecassic in human skin, especially in 3D skin models and clinical trials. To overcome the low transdermal delivery issue, we developed nanoe

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Gomes, Tiago Fernandes, Rebeca Calado, and Margarida Gonçalo. "Epidermal Barrier Dysfunction in Atopic Dermatitis." Journal of the Portuguese Society of Dermatology and Venereology 79, no. 3 (2021): 207–16. http://dx.doi.org/10.29021/spdv.79.3.1405.

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Impaired skin barrier is one of the hallmarks of atopic dermatitis (AD), with abnormalities in the cornified envelope, lipid lamellae, tight junctions and cutaneous microbiome. These findings are also present in nonlesional skin of AD individuals, suggesting that epidermal barrier defects may be the initial step towards the development of AD and eventually other atopic diseases (atopic march). It is currently known that pathophysiology of AD involves an interplay between this dysfunctional skin barrier and a predominantly type 2 skewed innate and adaptive immune responses, which further disrup

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Torres, Ana, Liliana Rego, Márcia S. Martins, et al. "How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies." Pharmaceuticals 16, no. 4 (2023): 573. http://dx.doi.org/10.3390/ph16040573.

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Skin repair encompasses epidermal barrier repair and wound healing which involves multiple cellular and molecular stages. Therefore, many skin repair strategies have been proposed. In order to characterize the usage frequency of skin repair ingredients in cosmetics, medicines, and medical devices, commercialized in Portuguese pharmacies and parapharmacies, a comprehensive analysis of the products’ composition was performed. A total of 120 cosmetic products, collected from national pharmacies online platforms, 21 topical medicines, and 46 medical devices, collected from INFARMED database, were

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Moreau, Joshua Michael, Devi P. Boda, and Michael D. Rosenblum. "Regulatory T cells in skin coordinate responses to epidermal injury by initiating anti-microbial immunity while delaying tissue repair." Journal of Immunology 204, no. 1_Supplement (2020): 75.15. http://dx.doi.org/10.4049/jimmunol.204.supp.75.15.

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Abstract When barrier tissues are breached, two coordinate responses need to occur: 1) clearance of pathogens and 2) repair of damaged epithelium. Regulatory T cells (Tregs) play a major role in skin barrier repair; however, the mechanisms by which they modulate local tissue are unclear. To identify molecular pathways underpinning Treg interactions with their tissue environment, we performed single cell RNA sequencing on Tregs isolated from the skin. Our analysis revealed elevated TGFβ and integrin signaling. Specifically, we found high expression of the latent TGFβ activating integrin, αvβ8.

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Dębińska, Anna, and Barbara Sozańska. "Epicutaneous Sensitization and Food Allergy: Preventive Strategies Targeting Skin Barrier Repair—Facts and Challenges." Nutrients 15, no. 5 (2023): 1070. http://dx.doi.org/10.3390/nu15051070.

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Food allergy represents a growing public health and socio-economic problem with an increasing prevalence over the last two decades. Despite its substantial impact on the quality of life, current treatment options for food allergy are limited to strict allergen avoidance and emergency management, creating an urgent need for effective preventive strategies. Advances in the understanding of the food allergy pathogenesis allow to develop more precise approaches targeting specific pathophysiological pathways. Recently, the skin has become an important target for food allergy prevention strategies,

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Tricarico, Paola Maura, Donatella Mentino, Aurora De Marco, et al. "Aquaporins Are One of the Critical Factors in the Disruption of the Skin Barrier in Inflammatory Skin Diseases." International Journal of Molecular Sciences 23, no. 7 (2022): 4020. http://dx.doi.org/10.3390/ijms23074020.

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The skin is the largest organ of the human body, serving as an effective mechanical barrier between the internal milieu and the external environment. The skin is widely considered the first-line defence of the body, with an essential function in rejecting pathogens and preventing mechanical, chemical, and physical damages. Keratinocytes are the predominant cells of the outer skin layer, the epidermis, which acts as a mechanical and water-permeability barrier. The epidermis is a permanently renewed tissue where undifferentiated keratinocytes located at the basal layer proliferate and migrate to

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Bock, Meike, Klaus Damer, Britta Wulfhorst, and Swen Malte John. "Semipermeable glove membranes-effects on skin barrier repair following SLS irritation." Contact Dermatitis 61, no. 5 (2009): 276–80. http://dx.doi.org/10.1111/j.1600-0536.2009.01622.x.

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Xhauflaire-Uhoda, E., V. Vroome, G. Cauwenbergh, and G. E. Piérard. "Dynamics of Skin Barrier Repair following Topical Applications of Miconazole Nitrate." Skin Pharmacology and Physiology 19, no. 5 (2006): 290–94. http://dx.doi.org/10.1159/000093985.

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Visscher, M. O., S. B. Hoath, E. Conroy, and R. R. Wickett. "Effect of semipermeable membranes on skin barrier repair following tape stripping." Archives of Dermatological Research 293, no. 10 (2001): 491–99. http://dx.doi.org/10.1007/pl00007463.

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Man, George, Carolyn Cheung, Debra Crumrine, et al. "An optimized inexpensive emollient mixture improves barrier repair in murine skin." Dermatologica Sinica 33, no. 2 (2015): 96–102. http://dx.doi.org/10.1016/j.dsi.2015.03.010.

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Yang, Gabsik, Jin Kyung Seok, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, and Joo Young Lee. "Skin Barrier Abnormalities and Immune Dysfunction in Atopic Dermatitis." International Journal of Molecular Sciences 21, no. 8 (2020): 2867. http://dx.doi.org/10.3390/ijms21082867.

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Abstract (sommario):

Atopic dermatitis (AD) is a common and relapsing skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. While AD was previously thought to occur primarily in children, increasing evidence suggests that AD is more common in adults than previously assumed. Accumulating evidence from experimental, genetic, and clinical studies indicates that AD expression is a precondition for the later development of other atopic diseases, such as asthma, food allergies, and allergic rhinitis. Although the exact mechanisms of the disease pathogenesis remain unclear, i

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Ye, Haifeng, and Yuval Rinkevich. "Fascia Layer—A Novel Target for the Application of Biomaterials in Skin Wound Healing." International Journal of Molecular Sciences 24, no. 3 (2023): 2936. http://dx.doi.org/10.3390/ijms24032936.

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As the first barrier of the human body, the skin has been of great concern for its wound healing and regeneration. The healing of large, refractory wounds is difficult to be repaired by cell proliferation at the wound edges and usually requires manual intervention for treatment. Therefore, therapeutic tools such as stem cells, biomaterials, and cytokines have been applied to the treatment of skin wounds. Skin microenvironment modulation is a key technology to promote wound repair and skin regeneration. In recent years, a series of novel bioactive materials that modulate the microenvironment an

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Boothby, Ian C., Jarish N. Cohen, and Michael D. Rosenblum. "Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair." Science Immunology 5, no. 47 (2020): eaaz9631. http://dx.doi.org/10.1126/sciimmunol.aaz9631.

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Abstract (sommario):

Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by “classical” suppressive mechanisms of Tregs and by “nonclassical” reparative Treg functions.

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Chikin, V. V. "Topical methylprednisolone aceponate and dexpanthenol in the treatment of patients with atopic dermatitis." Vestnik dermatologii i venerologii 90, no. 5 (2014): 112–16. http://dx.doi.org/10.25208/0042-4609-2014-90-5-112-116.

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Abstract (sommario):

The goals of the topical treatment of patients suffering from atopic dermatitis are suppression of the inflammatory reaction in the skin, elimination of itching, and recovery of the damaged protective lipid barrier of the epidermis. In this connection, topical glucocorticosteroids and skin moisturizers are used in the therapy of patients suffering from atopic dermatitis. Methylprednisolone aceponate (MPA, Advantan) being a topical glucocorticosteroid is characterized by high efficacy and safety. MPA is marked by the fast development of the therapeutic effect. This drug can be used for children

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45

Smythe, Paisleigh, and Holly N. Wilkinson. "The Skin Microbiome: Current Landscape and Future Opportunities." International Journal of Molecular Sciences 24, no. 4 (2023): 3950. http://dx.doi.org/10.3390/ijms24043950.

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Abstract (sommario):

Our skin is the largest organ of the body, serving as an important barrier against the harsh extrinsic environment. Alongside preventing desiccation, chemical damage and hypothermia, this barrier protects the body from invading pathogens through a sophisticated innate immune response and co-adapted consortium of commensal microorganisms, collectively termed the microbiota. These microorganisms inhabit distinct biogeographical regions dictated by skin physiology. Thus, it follows that perturbations to normal skin homeostasis, as occurs with ageing, diabetes and skin disease, can cause microbial

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46

Joukhadar, Radwan, Laura Nižić Nodilo, Jasmina Lovrić, Anita Hafner, Ivan Pepić, and Mario Jug. "Functional Nanostructured Lipid Carrier-Enriched Hydrogels Tailored to Repair Damaged Epidermal Barrier." Gels 10, no. 7 (2024): 466. http://dx.doi.org/10.3390/gels10070466.

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Abstract (sommario):

In this study, a functional nanostructured lipid carriers (NLCs)-based hydrogel was developed to repair the damaged epidermal skin barrier. NLCs were prepared via a high-energy approach, using argan oil and beeswax as liquid and solid lipids, respectively, and were loaded with ceramides and cholesterol at a physiologically relevant ratio, acting as structural and functional compounds. Employing a series of surfactants and optimizing the preparation conditions, NLCs of 215.5 ± 0.9 nm in size and a negative zeta potential of −42.7 ± 0.9 were obtained, showing acceptable physical and microbial st

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Luo, Yonghong, та Wendy B. Bollag. "The Role of PGC-1α in Aging Skin Barrier Function". Cells 13, № 13 (2024): 1135. http://dx.doi.org/10.3390/cells13131135.

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Abstract (sommario):

Skin provides a physical and immune barrier to protect the body from foreign substances, microbial invasion, and desiccation. Aging reduces the barrier function of skin and its rate of repair. Aged skin exhibits decreased mitochondrial function and prolonged low-level inflammation that can be seen in other organs with aging. Peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1α (PGC-1α), an important transcriptional coactivator, plays a central role in modulating mitochondrial function and antioxidant production. Mitochondrial function and inflammation have been linked to epiderma

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48

Alia, Vrenda, Suci Widhiati, Triasari Oktavriana, Lifesia Natali Lidjaja, and Laura Noviani. "Sukralfat as a Therapy for Reducing Itching and Repairing the Skin Barrier: A Systematic Review." Journal La Medihealtico 5, no. 4 (2024): 816–29. http://dx.doi.org/10.37899/journallamedihealtico.v5i4.1508.

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Abstract (sommario):

Sucralate is an aluminum salt from sucrose octasulfate that is known for its anti-ulcer activity, mucosal protection, and anti-mucositis potential. Recently, sucralfat has been used topically for the healing of various epithelial wounds, including ulcers, inflammatory dermatitis, mucositis, and burns. This systematic review aimed to evaluate the effectiveness of sucralfat as a topical therapy in reducing itching (pruritus) and improving the skin barrier. The analysis method used is Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). A literature search was conducted on

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Dussoyer, Mélissa, Anna Michopoulou, and Patricia Rousselle. "Decellularized Scaffolds for Skin Repair and Regeneration." Applied Sciences 10, no. 10 (2020): 3435. http://dx.doi.org/10.3390/app10103435.

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Abstract (sommario):

The skin is the largest organ in the body, fulfilling a variety of functions and acting as a barrier for internal organs against external insults. As for extensive or irreversible damage, skin autografts are often considered the gold standard, however inherent limitations highlight the need for alternative strategies. Engineering of human-compatible tissues is an interdisciplinary and active field of research, leading to the production of scaffolds and skin substitutes to guide repair and regeneration. However, faithful reproduction of extracellular matrix (ECM) architecture and bioactive cont

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Leoty-Okombi, Sabrina, Florence Gillaizeau, Sébastien Leuillet, et al. "Effect of Sodium Lauryl Sulfate (SLS) Applied as a Patch on Human Skin Physiology and Its Microbiota." Cosmetics 8, no. 1 (2021): 6. http://dx.doi.org/10.3390/cosmetics8010006.

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Abstract (sommario):

In this study, we assessed the change in skin microbiota composition, relative abundance, and diversity with skin physiology disruption induced by SLS patch. Healthy women declaring to have a reactive skin were submitted to a 0.5% aqueous sodium lauryl sulfate solution application under occlusive patch condition for 24 h. Skin properties were characterized by tewametry, corneometry, and colorimetry and bacterial diversity was assessed by 16S rRNA sequencing. Analysis before and one day after SLS patch removal revealed an increase of skin redness and a decrease of stratum corneum hydration and

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