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Tesi sul tema "Skin therapeutics"

Autore: Grafiati
Pubblicato: 7 giugno 2025
Ultima modifica: 2 agosto 2025

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1

Al-Mayahy, Mohammed Hussain Neama. "Insights regarding drug permeation into skin." Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/47341/.

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In order to develop safe and effective topical and transdermal formulations to treat either local skin disorders or for systemic drug delivery, it is first imperative to assess skin permeation using a reliable and comprehensive analysis method. The assessment of drug permeation into/across the skin is traditionally accomplished using Franz diffusion cells with subsequent analysis by conventional chromatographic methods such as HPLC and more recently using advanced imaging techniques. In this context, time of flight-secondary ion mass spectrometry (ToF-SIMS) offers distinctive advantages in map
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2

Ivory, Matthew Owen. "Characterising skin immune cells to inform development of intradermal vaccines and therapeutics." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/96969/.

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Epidermal Langerhans cells (LCs) and multiple subsets of dermal dendritic cells (dDCs) make skin a valuable route for vaccination, offering the potential for antigen-sparing immunisation. The interconnected immunological functions of dDC subsets and LCs are not fully understood however. This Thesis therefore aimed to explore the interactions of skin immune cells with viral pathogens and vaccines to inform the development of future therapeutics and intradermal vaccines. LCs and dDCs were isolated from ex vivo human skin tissue using a walkout protocol which allowed the enrichment of the migrato
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3

Monshi, Manal. "Characterisation of the cellular basis of beta-lactam induced skin and liver injury." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/18373/.

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Drug hypersensitivity reactions are a significant cause of patient morbidity and mortality. They are difficult to predict in the clinic and during the drug development process. This is because mechanisms have not been fully elucidated. In fact, recent data using T-cells cloned from hypersensitive human patients have questioned the long-standing hapten concept, which states that a drug must bind irreversibly to protein to initiate a T-cell response. The work described herein was performed to investigate the chemical and cellular mechanisms of β-lactam-induced skin and liver injury and in partic
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4

Hindi, Tarek el [Verfasser]. "In vitro reproduction of clinical symptoms of atopic dermatitis in a newly developed organotypic skin model as a test-system for therapeutics / Tarek el Hindi." Aachen : Shaker, 2004. http://d-nb.info/117053161X/34.

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5

McAdler, Marisa M. "The Relationship Between Vitamin D Status of Adult Women and Diet, Sun Exposure, Skin Reflectance, Body Composition, and Insulin Sensitivity." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/1090.

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As the prevalence of vitamin D deficiency continues to grow, mounting evidence supporting its link with chronic disease strengthens suggesting vitamin D’s candidacy in the prevention and treatment of multiple disease states and their complications. Dietary guidelines, however, do not take sun exposure into account. The present study sought to explore the impact of sun exposure on vitamin D status (serum 25(OH)D), and identify other significant determinants of serum levels which may have the greatest effects on overall health. Participants (n = 34) were pre-menopausal women aged 18 to 50 years
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6

Fountas-Davis, Natalie D. "A NOVEL CHITOSAN-BASED WOUND HEALING HYDROGEL FOR THE ENHANCEMENT OF LOCAL OXYGEN LEVELS AND FOR THE FACILITATION OF DERMAL TISSUE REPAIR." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron155567641759327.

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7

Thomas, Beverley Jayne. "Gene therapy of melanoma : therapeutic and pharmaceutical investigations." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338377.

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8

Justiniano, Rebecca, and Rebecca Justiniano. "From Molecular Mechanisms of UVA-Induced Skin Photooxidative Stress to Experimental Therapeutic Interventions Targeting Skin Cancer." Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625465.

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Ultraviolet A is a major spectral component of solar electromagnetic energy reaching the surface of the earth. Excessive exposure to solar UVA is a known contributor to skin photoaging and photocarcinogenesis, associated with increased incidence rates and a significant health burden imposed by skin cancer worldwide. However, the molecular mechanisms underlying UVA-induced skin photodamage remain largely undefined. UVA radiation has been shown to cause cutaneous oxidative stress and photosensitization reactions involving the light-driven photochemistry of specific skin chromophores upstream of
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9

Bentley, Mary Jane. "Development and Evaluation of Disease Activity Measures in Rheumatoid Arthritis Using Multi-Level Mixed Modeling and Other Statistical Methodologies: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/461.

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Remarkable progress has been made in the development of effective treatments for patients with rheumatoid arthritis (RA). To ensure that a patient is optimally responding to treatment, consistent monitoring of disease activity is recommended. Established composite and individual disease activity measures often cannot be computed due to missing laboratory values. Simplified measures that can be calculated without a lab value have been developed and previous studies have validated these new measures, yet differences in their performance compared with established measures remain. Therefore, the g
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10

Young, Stephen Robert. "The effect of therapeutic ultrasound on the biological mechanisms involved in dermal repair." Thesis, King's College London (University of London), 1988. https://kclpure.kcl.ac.uk/portal/en/theses/the-effect-of-therapeutic-ultrasound-on-the-biological-mechanisms-involved-in-dermal-repair(6c2b4920-3344-4112-80f3-04fec1bfefdf).html.

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11

Jahan, Fatima Naushin. "Are elastic liposomes better for skin delivery of therapeutic molecules?" Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/1623.

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The objectives of the present study were to design and evaluate elastic liposomes in comparison to simple drug solution and conventional liposomes, and in delivering a model NSAID, Ibuprofen (IBU) across human epidermis after topical application. The scope of the project included formulation development, characterization, and optimization based on their physical characteristics and determination of IBU penetration when incorporated in conventional and elastic liposomes through human epidermis after topical application, and finally to establish the relationship between the formulation variables
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12

Miller, David M. "TLR Activation Prevents Hematopoietic Chimerism Induced by Costimulation Blockade: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/368.

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Costimulation blockade based on a donor-specific transfusion and anti-CD154 mAb is effective for establishing mixed allogeneic hematopoietic chimerism and inducing transplantation tolerance. Despite its potential, recent evidence suggests that the efficacy of costimulation blockade can be reduced by environmental perturbations such as infection or inflammation that activate toll-like receptors (TLR). TLR agonists prevent costimulation blockade-induced prolongation of solid organ allografts, but their effect on the establishment of hematopoietic chimerism has not been reported. In this disserta
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13

Ding, Hongliu. "Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/404.

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Breast cancer, osteoporosis, and coronary heart disease (CHD) are three major threats to women’s health. Postmenopausal women with breast cancer are also at high risk for osteoporosis and CHD. Adjuvant tamoxifen therapy is not only an effective treatment for breast cancer, but has been shown to have a beneficial effect on bone and the cardiovascular system. Although tamoxifen has been convincingly demonstrated to be able to preserve bone mineral density (BMD), an unexpected increase of risk of fractures in patients treated with tamoxifen has been reported. The findings of the association of ta
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14

Sirois, Cherilyn M. "Nucleic Acid Sensing by the Immune System: Roles For the Receptor For Advanced Glycation End Products (RAGE) and Intracellular Receptor Proteins: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/551.

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As humans, we inhabit an environment shared with many microorganisms, some of which are harmless or beneficial, and others which represent a threat to our health. A complex network of organs, cells and their protein products form our bodies’ immune system, tasked with detecting these potentially harmful agents and eliminating them. This same system also serves to detect changes in the healthy balance of normal functions in the body, and for repairing tissue damage caused by injury. Immune recognition of nucleic acids, DNA and RNA, is one way that the body detects invading pathogens and initiat
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15

Thornley, Thomas B. "IFN-α/β Induction by dsRNA and Toll-Like Receptors Shortens Allograft Survival Induced by Costimulation Blockade: A Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/254.

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Abstract (sommario):
Costimulation blockade protocols are promising alternatives to the use of chronic immunosuppression for promoting long-term allograft survival. However, the efficacy of costimulation blockade-based protocols is decreased by environmental insults such as viral infections. For example, lymphocytic choriomeningitis virus (LCMV) infection at the time of costimulation blockade treatment abrogates skin allograft survival in mice. In this dissertation, we test the hypothesis that viruses shorten allograft survival by activating the innate immune system through pattern-recognition receptors (PRRs), su
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16

Fell, Benjamin. "Organotypic human skin disease models for the assessment of novel therapeutic approaches." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24594.

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Comprehensive in vitro modelling of inflammatory human skin conditions is an essential first step in the development and assessment of potential therapeutic approaches. Mouse models or monolayer keratinocyte cultures come with distinct limitations which might be complimented or overcome by the use of human-specific organotypic 3D culture models. Over the course of this thesis, an organotypic culture system, based on patientderived immortalised keratinocyte cell lines on a dermal equivalent collagen 1 gel, was established and used to recapitulate phenotypical features for two hereditary skin di
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17

Liu, Xuelai, and 劉雪來. "The role of silver nanoparticles on skin wound healing, tissue remodeling and their potential cytotoxicity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/195985.

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The advance of nanotechnology has made it possible that pure silver can be engineered into nano scale level with less than 100 nm in size. So far many studies have confirmed anti-bacterial and anti-inflammatory efficacy of silver nanoparticles (AgNPs). In our previous study we have revealed that AgNPs could promote wound healing through modulation of cytokines in a burn wound model in mice. Nonetheless, the exact effects mediated by AgNPs on various cell types in skin, including keratinocytes and fibroblasts, during wound healing still remain unknown. Therefore, in the present study we targete
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18

Gomes, Dora Godinho Lopes de Melo. "Equine sarcoids : a therapeutic challenge." Bachelor's thesis, Universidade Técnica de Lisboa. Faculdade de Medicina Veterinária, 2011. http://hdl.handle.net/10400.5/3509.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>Equine Sarcoid is the most common skin tumor in horses and other equidea, where bovine papilomavirus (BPV) plays a major role in its etiopathogenesis. Sarcoids are characterized as unique locally invasive, non-metastatic, fibroblastic skin tumors with unpredictable behavior and are considered to cause substantial economic loss to the equine industry. Several methods have been employed in the treatment of this condition, however, no current approach was found to be 100% effective or universal for all tumor types and locations and rec
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19

Tessier, Agnès. "Procollagen C-Proteinase Enhancers in skin wound healing : expression, functions and therapeutic potential." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1105.

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La balance entre synthèse et dégradation des collagènes joue un rôle crucial dans le développement de pathologies de cicatrisation. Les collagènes fibrillaires sont synthétisés et sécrétés sous forme de précurseurs dans l'espace extracellulaire. Ils subissent alors une maturation protéolytique par des métalloprotéases, telles que les « BMP-1/Tolloid-like » (BTPs), permettant la formation de fibres de collagène. Ce clivage protéolytique est stimulé de façon spécifique par deux glycoprotéine, les « Procollagen C-Proteinase Enhancers » (PCPE-1 et -2). Ainsi, l'objectif de mon travail de recherche
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20

Zulfiker, Abu Hasanat Md. "Compound Identification and Functional Characterisation of Cane Toad Skin Extracts." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/365733.

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Amphibians are storehouse of bioactive compounds. Among them, the skin of toad species is rich in biologically active compounds such as peptides, proteins, steroids, alkaloids and opioids. Some of these compounds have found significant therapeutic applications, for example as antibacterials, antifungals, antiprotozoals, antidiabetics, antineoplastics, analgesics and sleep inducing agents. In Traditional Chinese Medicine (TCM) aqueous extracts of Chinese toad skins have been used for centuries to treat pain, swelling, heart failure and several types of cancer with minimal to no side effects, ge
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21

Wiegleb, Edström Desiree. "Long-wave ultraviolet radiation (UVA1) and visible light : therapeutic and adverse effects in human skin /." Stockholm : [Karolinska Univ. Press], 2001. http://diss.kib.ki.se/2001/91-7349-003-2/.

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22

Wulff, Brian Charles. "Effects of Therapeutic Immunosuppressants on UVB Induced Inflammation and Skin Carcinogenesis in a Murine Model." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1227116356.

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23

Milosevic, Jelena. "Isolation and characterization of therapeutic and biotechnological molecules from Olea europaea." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325851.

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24

RIBEIRO, MARTHA S. "Interacao da radiacao laser linearmente polarizada de baixa intensidade com tecidos vivos: efeitos na acelaracao de cicatrizacao tissular em lesoes de pele." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10878.

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25

SUGAYAMA, STELLA T. "Efeitos da radiação laser em baixa intensidade na cicatrização de queimaduras de pele. Estudo laser doppler fluxométrico e histológico em ratos." reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11496.

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26

Barros, Ana Regina de Souza Bavaresco. "Os efeitos do ultra-som terapêutico nas lesões da epiderme de coelhos." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-19022016-142259/.

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O ultra-som terapêutico é o recurso físico mais empregado como coadjuvante na promoção do reparo tecidual em vários tipos de lesão de partes moles. Neste trabalho, foi estudada a influência do ultra-som terapêutico no processo de cicatrização de feridas cutâneas num modelo experimental em coelhos. Foram utilizados 36 coelhos adultos, nos quais foram produzidas três lesões cutâneas no dorso, pela ressecção de um segmento circular de pele de 1 cm de diâmetro, distando 5 cm uma da outra, em linha. Uma das lesões era submetida ao tratamento efetivo com o ultra-som, a outra era submetida a tratamen
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27

Magcwebeba, Tandeka Unathi. "Chemopreventive properties of South African herbal teas, rooibos (Aspalathus linearis) and honeybush (Cyclopia spp) : mechanisms against skin carcinogenesis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85632.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: The present study employed a two-phased approach to investigate the possible mechanisms involved in the chemopreventive properties of rooibos (Aspalathus linearis) and different honeybush species (Cyclopia spp.) in vitro. In the first phase, the effect of unfermented methanol and aqueous herbal tea extracts against the growth parameters (cell viability, proliferation and apoptosis) of normal (CRL 7761); premalignant (HaCaT); and malignant (CRL 7762) skin cells was evaluated and compared to green tea extracts. The predictive pote
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28

SILVA, DANIELA de F. T. da. "Analise da birrefringencia do colageno e do coeficiente de atenuacao de amostras de pele sadia e queimada irradiadas pelo laser de He-Ne linearmente polarizado." reponame:Repositório Institucional do IPEN, 2002. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11005.

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29

Samarkanova, Dinara. "Umbilical Cord Blood Platelet Rich Plasma derivatives for therapeutic applications and development of clinical trials for treatment of skin and ocular ulcers." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670817.

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Entre els avantatges en l'ús de la sang de cordó (CB) com a font de plaquetes i de l'plasma per a la medicina regenerativa es destaquen la disponibilitat, l'ús universal i el material biològic viralment segur, ric en factors regeneratius. Els derivats de l'plasma ric en plaquetes de cordó (CB-PRP) s'han investigat com a possibles agents terapèutics per al tractament de diverses afeccions, entre elles les malalties de la superfície ocular i les úlceres de la pell. L'objectiu d'aquesta tesi és validar un disseny de bioprocés per a la producció de concentrats de plaquetes derivats de cordó (CB
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30

De, Kwaadsteniet Michele. "Characterization of nisin F and its role in the control of respiratory tract and skin infections." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1285.

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Thesis (PhD (Microbiology))--University of Stellenbosch, 2009.<br>Multidrug resistant strains of Staphylococcus aureus is presenting an increasing threat, especially immune compromised individuals. Many of these strains have developed resistance to newly approved drugs such as quinupristin-dalfopristin, linezolid and daptomycin. The search for alternative treatment, including bacteriocins (ribosomally synthesized antimicrobial peptides) of lactic acid bacteria is increasing . Lactococcus lactis subsp. lactis F10, isolated from freshwater catfish, produced a new nisin variant active again
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31

Farrokhi, Ali. "Evaluating the therapeutic use of Indoleamine 2,3-dioxygenase (IDO) expressing allogenic dermal fibroblast populated within an acellular skin substitute as a wound coverage." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63529.

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Shanaube, Kwame, James Hargreaves, Katherine Fielding, et al. "Risk factors associated with positive quantiFERON-TB gold in-tube and tuberculin skin tests results in Zambia and South Africa." Public Library of Science (PLOS), 2011. http://hdl.handle.net/10019.1/11596.

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The original publication is available at http:/www.plosone.org<br>Introduction: The utility of T-cell based interferon-gamma release assays for the diagnosis of latent tuberculosis infection remains unclear in settings with a high burden of tuberculosis. Objectives: To determine risk factors associated with positive QuantiFERON-TB Gold In-Tube (QFT-GIT) and tuberculin skin test (TST) results and the level of agreement between the tests; to explore the hypotheses that positivity in QFT-GIT is more related to recent infection and less affected by HIV than the TST. Methods: Adult household contac
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33

Garcia, Mayea Yoelsis. "Novel therapeutic approaches against Head and Neck Squamous Cell Carcinoma." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/672185.

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Head and neck squamous cell carcinoma (HNSCC) is usually diagnosed in advanced stages. The treatment has not changed much on the last decades, being limited to surgery followed by radiotherapy and/or chemotherapy [mainly cisplatin (CDDP) and 5-fluorouracil (5-FU)]. However, the acquisition of chemotherapy resistance is very common, which usually leads to recurrences and metastases. On the other hand, the role of autophagy in HNSCC is not clearly defined. This is the reason why in this thesis we have proposed: 1) to determine the role of autophagy in HNSCC models and its relationship with chemo
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34

Au, Wai Ling. "Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003221.

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Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment o
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35

Javedan, Khosrow. "Investigation of Buildup Dose for Therapeutic Intensity Modulated Photon Beams in Radiation Therapy." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3449.

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Buildup dose of Mega Voltage (MV) photon beams can be a limiting factor in intensitymodulated radiation therapy (IMRT) treatments. Excessive doses can cause patient discomfort and treatment interruptions, while underdosing may lead to local failure. Many factors which contribute to buildup dose, including the photon beam energy spectrum, scattered or contaminant radiation and their angular distribution, are not modeled well in commercial treatment planning systems. The accurate Monte Carlo method was employed in the studies to estimate the doses. Buildup dose of 6MV photon beams was investigat
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REZENDE, SANDRA B. "Acao do diodo laser emitindo em 830 nm, sobre o processo de cicatrizacao de lesoes cutaneas: estudo biometrico e histologico em ratos." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10928.

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Marsavela, Anda-Gabriela. "Assessment of the clinical validity of ctDNA Analysis for melanoma management." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2021. https://ro.ecu.edu.au/theses/2407.

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Metastatic melanoma is responsible for almost 80% of all skin cancer-related deaths and the incidence of people affected continues to rise worldwide. The emergence of targeted therapy and immune-checkpoint inhibitors has improved the clinical management of melanoma, but durable survival benefit is only seen in a minority of patients. The use of these very expensive systemic therapies on all appropriate patients also poses a high economic burden on health systems across numerous countries. Currently, surveillance for treatment failure is not optimal. Thus, reliable and accurate biomarkers of pa
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Amancio, Adriana da Costa Gonçalves. "Efeitos do ultra-som terapêutico na integração de enxertos de pele total em coelhos." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/82/82131/tde-20082003-110748/.

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O ultra-som terapêutico é um recurso físico muito empregado como coadjuvante na promoção do reparo tecidual. Neste trabalho, foi estudada a influência do ultra-som terapêutico na integração dos enxertos de pele total num modelo experimental em coelhos. Foram utilizados 20 coelhos adultos, fêmeas, nos quais foram realizadas cirurgias de enxerto autógeno de pele total nas regiões escapulares, pela ressecção de dois retalhos quadrados de pele de 2 cm de lado, invertendo sua posição, o enxerto retirado do lado direito sendo colocado na área receptora esquerda e vice-versa. O enxerto do lado direi
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39

Haddad, Alessandra [UNIFESP]. "Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9790.

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Made available in DSpace on 2015-07-22T20:50:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-28<br>INTRODUÇÃO: Rejuvenescimento fotodinâmico refere-se ao tratamento do fotoenvelhecimento e das queratoses actínicas. OBJETIVO: Avaliar a eficácia da terapia fotodinâmica com ácido aminolevulínico a 20% (ALA) ¾ tópico e luz intensa pulsada no tratamento das queratoses actínicas e do fotoenvelhecimento facial. MÉTODOS: Quarenta e três pacientes com idade média 71,3 anos, fototipos de pele I e IV divididos em: Controle (aplicação LIP/18J); Tratamento-I (ALA incubado por duas horas; at
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40

Lopes, Karine Helena de Souza. "Estudo comparativo dos efeitos do laser de baixa intensidade e do ultrassom terapêutico no reparo tecidual de feridas cirúrgicas cutâneas em ratos Wistar: avaliação histomorfométrica e imunoistoquímica." Universidade Federal de Juiz de Fora, 2012. https://repositorio.ufjf.br/jspui/handle/ufjf/1935.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-07-01T13:51:16Z No. of bitstreams: 1 karinehelenadesouzalopes.pdf: 1140714 bytes, checksum: b276a86b4727bee8ef060477fc027e6b (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-07-13T16:01:04Z (GMT) No. of bitstreams: 1 karinehelenadesouzalopes.pdf: 1140714 bytes, checksum: b276a86b4727bee8ef060477fc027e6b (MD5)<br>Made available in DSpace on 2016-07-13T16:01:04Z (GMT). No. of bitstreams: 1 karinehelenadesouzalopes.pdf: 1140714 bytes, checksum: b276a86b4727bee8ef060477fc027e6b (MD5)
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Carneiro, Renata Valente. "Uso de acitretina para prevenção e tratamento de câncer de pele em transplantados renais: avaliação clínica, histológica e imuno-histoquímica." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-19042007-091241/.

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Os doentes transplantados renais têm alto risco para desenvolver queratoses actínicas e câncer de pele. Para verificar o efeito quimioprofilático da acitretina estudamos a evolução de 13 doentes transplantados renais com queratoses actínicas múltiplas e história de carcinomas cutâneos submetidos a tratamento por 12 meses (20mg/dia). Fez-se a avaliação clínica e laboratorial regularmente em todo o período do estudo. Realizou-se exame histopatológico, demonstração imuno-histoquímica de sub-populações de linfócitos T (CD4, CD8), células natural killer e células de Langerhans, sua quantificação e
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42

Meski, Ana Paula Gomes. "Estudo comparativo da pele pré- e pós-quimioabrasão para tratamento de rítides da região perioral: avaliação clínica e imuno-histoquímica." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-19032007-093446/.

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Atualmente existem vários tratamentos para melhorar a aparência da pele com fotoenvelhecimento. A quimioabrasão é uma dessas técnicas, consiste na associação de esfoliação química com ácido tricloroacético a 35%, seguida por dermabrasão. O ácido tricloroacético facilita a dermabrasão por promover coagulação das proteínas da pele, tornando-a mais friável. Além disto, produz um branqueamento na pele que está relacionado ao seu grau de penetração, auxiliando a uniformização da profundidade atingida com a dermabrasão. A técnica de dermabrasão utilizada neste estudo, foi manual com lixas d?água, po
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43

Ropke, Cristina Dislich. "Prevenção do dano fotooxidativo à pele por tratamento tópico com extrato da raiz de Pothomorphe umbellata L. Miq." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-26112015-143703/.

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Entre as estratégias de fotoproteção encontra-se a inibição da formação e/ou o seqüestro de radicais livres e espécies reativas de oxigênio geradas em conseqüência da exposição à radiação UV, mediante aplicação tópica de antioxidantes. No presente trabalho avaliou-se a permeação cutânea e o efeito da aplicação tópica de um extrato de Pothomorphe umbellata nos efeitos da exposição aguda e crônica à radiação ultravioleta, na pele de camundongos sem pêlo. No estudo de permeação cutânea foram testadas três formulações (gel, gel-creme e creme) contendo o princípio ativo do extrato (4-nerolidilcatec
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44

Salles, Alessandra Grassi. "Efeito do tratamento combinado com tretinóina e ácido glicólico na abertura bucal de pacientes com seqüela de queimadura." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5158/tde-04012007-172935/.

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O processo de reparação tecidual evolui tardiamente com alteração das propriedades físicas da pele, cuja gravidade varia, entre outros fatores, em função da profundidade original da lesão. Clinicamente a pele é seca, descamativa, discrômica e com diminuição da elasticidade, especialmente em cicatrizes hipertróficas. As características do tegumento pós-queimadura podem ser melhoradas com agentes de uso tópico normalmente utilizados em patologias como acne e fotoenvelhecimento. Foram avaliados 77 pacientes portadores de seqüela de queimadura peri-oral, entre seis e 46 anos de idade. O tipo de te
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45

Miller, Andrew B. "Antimicrobial and Anticancer Activity of Essential Oils from Guatemalan Medicinal Plants." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2411.

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Guatemalan medicinal plants were collected and screened for the presence of essential oils using steam distillation. Oil was found in 63 species from 24 families and was tested in tube dilution assays for activity against Escherichia coli, Staphylococcus aureus, Streptococcus mutans, Lactobacillus acidophilus and Candida albicans. Several essential oils were highly active with 20 instances of oils inhibiting the microbes at an MIC of 0.31 µl/ml. Oils were also tested against cancerous and established cell lines using a 15% (v/v) agar-media which was developed to improve essential oil solubilit
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46

Silva, Andréa Fernandes Emiliano da. "Estudo das alterações cardiovasculares e metabólicas em modelo experimental de programação metabólica: efeito de extrato da casca de uva Vitis vinífera." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6293.

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Estudos epidemiológicos e experimentais têm sugerido que fatores de risco cardiovasculares podem ser parcialmente atribuídos às influências do ambiente em que vive o indivíduo, e que a nutrição materna influencia na programação de alterações metabólicas e cardiovasculares no indivíduo adulto e que caracterizam a síndrome metabólica (SM). Em contrapartida, estudos prévios de nosso laboratório demonstram que o extrato da casca de uva Vitis labrusca (GSE) possui efeito vasodilatador, antihipertensivo e antioxidante. Desta forma, o objetivo deste estudo foi avaliar o efeito do tratamento oral com
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47

Lu, Wan-Cheng, and 盧宛辰. "Study on the platform development of skin care and therapeutics for skin disease." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/45895785164950918664.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>98<br>Skin inflammation has evolved as a protective response to injury, thus eliminates foreign organisms or material, and the resolution of inflammation protect us against excessive tissue injury. A failure of resolution cause chronic inflammation, and lead to many skin diseases. In this study, we use common TLR ligand LPS and PKC agonist TPA to stimulate NF-κB pathway in human keratinocyte, for in vitro mimic skin inflammation. When keratinocyte was induced by LPS, NO production was increase, then treat Taraxacum mongolicum extract, Palmae coconut nucifera L. extra
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48

Hirshburg, Jason M. "Chemical Agent Induced Reduction of Skin Light Scattering." 2009. http://hdl.handle.net/1969.1/ETD-TAMU-2009-12-7247.

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Skin turbidity limits light based medical applications while increasing the risk of epidermal thermal injury. Collagen fibers are responsible for the majority of light scattering within skin. Chemicals, known as clearing agents, reduce tissue light scattering with the potential to increase the efficacy of light based imaging and therapeutic applications. Three hypotheses have been suggested for the clearing mechanism: index of refraction matching between clearing agent and collagen, tissue dehydration, and agent induced collagen structure perturbation. This study investigates optical clearing
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49

Nayak, Debasis. "Ethosomal Nano-carriers Encapsulating Novel Green Synthesized AgNPs and Sericin Protein as Potential Therapeutics against Skin Carcinoma." Thesis, 2018. http://ethesis.nitrkl.ac.in/9427/1/2018_PhD_DNayak_512LS101_Ethosomal.pdf.

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UV radiations are the main etiological factor that contributes to the induction of skin carcinoma. The incidence of skin carcinoma is increasing at an alarming rate both in the Indian and worldwide scenario. Due to the ignorance and socioeconomic conditions, most of the non-melanoma skin cancer (NMSC) cases are not registered in the national and state cancer registry. Therefore, development of new therapeutics having higher efficacy along with skin regenerative properties is one of the important issues in today’s rapid and progressive world. In this study, novel and economic resources were sel
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Figueiredo, Ana Carolina de Almeida. "Terapêutica fotodinâmica em Dermatologia: aplicações atuais e potenciais." Master's thesis, 2017. http://hdl.handle.net/10316/82614.

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Trabalho de Projeto do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>A terapêutica fotodinâmica requer três elementos: a luz, o fotossensibilizante e o oxigénio. A reação fotodinâmica leva a destruição celular duplamente seletiva, já que a fonte de luz é direcionada para a lesão e porque o fotossensibilizante é preferencialmente absorvido pelas células em proliferação. É uma técnica bem tolerada, pouco invasiva e com excelentes resultados cosméticos. É limitada principalmente pela capacidade de absorção do fotossensibilizante e pela dor durante a irradiação. Atualmente
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