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Articoli di riviste sul tema "Skin therapeutics"

Autore: Grafiati

Pubblicato: 7 giugno 2025

Ultima modifica: 2 agosto 2025

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1

Burgdorf, Walter H. C. "Topical skin therapeutics." Journal of the American Academy of Dermatology 12, no. 5 (1985): 909–10. http://dx.doi.org/10.1016/s0190-9622(85)80152-3.

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2

Maibach, Howard I. "Topical Skin Therapeutics." Archives of Dermatology 121, no. 10 (1985): 1340. http://dx.doi.org/10.1001/archderm.1985.01660100120034.

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3

Borthakur, S., P. Mande, D. Rios, et al. "AB0019 TREATMENT OF AUTOIMMUNE AND INFLAMMATORY SKIN DISEASES USING SKIN-TARGETING BIFUNCTIONAL ANTIBODIES: A LOCALIZED IMMUNOMODULATION APPROACH." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1043.3–1044. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1665.

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Background:Current treatment approaches for autoimmune conditions comprise primarily of systemic immunosuppressants or cytokine blockade. The concentration of therapeutic molecules to the tissues that are the sites of autoimmune and inflammatory diseases is a promising approach with the potential to induce therapeutic benefit and avert risks associated with systemic immunotherapies. Pandion Therapeutics is developing a bifunctional antibody platform that can drive localized immune modulation by combining a “tether antibody” that targets a tissue of choice and “an effector end” that activates s

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4

Uitto, Jouni. "Molecular Therapeutics for Heritable Skin Diseases." Journal of Investigative Dermatology 132 (November 2012): E29—E34. http://dx.doi.org/10.1038/skinbio.2012.9.

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5

Lindley, Celeste M., and Suzanne Emerson Cronquist. "Skin Cancers: Detection, Prevention, and Therapeutics." American Pharmacy 28, no. 4 (1988): 32–41. http://dx.doi.org/10.1016/s0160-3450(15)31976-0.

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6

Lee, Eun Kwang, Min Ku Kim, and Chi Hwan Lee. "Skin-Mountable Biosensors and Therapeutics: A Review." Annual Review of Biomedical Engineering 21, no. 1 (2019): 299–323. http://dx.doi.org/10.1146/annurev-bioeng-060418-052315.

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Miniaturization of electronic components and advances in flexible and stretchable materials have stimulated the development of wearable health care systems that can reflect and monitor personal health status by health care professionals. New skin-mountable devices that offer seamless contact onto the human skin, even under large deformations by natural motions of the wearer, provide a route for both high-fidelity monitoring and patient-controlled therapy. This article provides an overview of several important aspects of skin-mountable devices and their applications in many medical settings and

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7

Shiu, Simon C. C., Andrew B. Kinghorn, and Julian A. Tanner. "Topical DNA aptamer therapeutics for the skin." Molecular Therapy - Nucleic Acids 35, no. 3 (2024): 102299. http://dx.doi.org/10.1016/j.omtn.2024.102299.

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Ingber, Arieh. "Breaking the Rules of Topical Skin Therapeutics." SKINmed: Dermatology for the Clinician 2, no. 3 (2003): 181. http://dx.doi.org/10.1111/j.1540-9740.2003.01838.x.

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9

Sreedhar, Annapoorna, Jun Li, and Yunfeng Zhao. "Next-Gen Therapeutics for Skin Cancer: Nutraceuticals." Nutrition and Cancer 70, no. 5 (2018): 697–709. http://dx.doi.org/10.1080/01635581.2018.1470651.

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10

Son, Young Ju, John W. Tse, Yiran Zhou, Wei Mao, Evelyn K. F. Yim, and Hyuk Sang Yoo. "Biomaterials and controlled release strategy for epithelial wound healing." Biomaterials Science 7, no. 11 (2019): 4444–71. http://dx.doi.org/10.1039/c9bm00456d.

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Skin and cornea tissues provide protective functions. Therapeutics to injuries aim to enhance wound healing efficiency and quality. Although the tissues share similar anatomic structures and wound healing process, therapeutic strategies differ.

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11

N., Priyanka, and R. Srinivasan. "A review on drug induced skin disorders: pathophysiology and therapeutics." International Journal of Research in Dermatology 6, no. 5 (2020): 715. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20203761.

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<p class="abstract"><span lang="EN-US">Drugs are the central part of treatment of various disorders. The consequence of drug use may be either positive outcomes (clinical effect of the drug) or negative outcomes (adverse drug events). That is, it contains both risk and benefit. In recent years multiple disorders treated with many drugs by monotherapy or by fixed-dose therapy existing in the market which leads to increased drug-related problems one among that is drug-induced disorders. Morbidity and mortality have increased due to drug-induced disorders. This study was aimed to desc

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12

Xu, Shuai, and Stacy Wang. "Assessing Patient Concerns Regarding Seborrheic Keratoses on the Face: Comparison Against Other Cosmetic Concerns." SKIN The Journal of Cutaneous Medicine 2 (December 17, 2018): S73. http://dx.doi.org/10.25251/skin.2.supp.73.

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Xu, Shuai, Stacy Wang, and Esther Estes. "The Hidden Impact of Seborrheic Keratoses: Analysis of a Psychometric Survey of an Ethnically Diverse Cohort of U.S. Adults." SKIN The Journal of Cutaneous Medicine 2 (December 17, 2018): S74. http://dx.doi.org/10.25251/skin.2.supp.74.

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14

Callender, Valerie, Ellen Frankel, Jonathan Weiss, et al. "Open-Label Study of A-101, a 40% Hydrogen Peroxide Topical Solution, in Patients With Seborrheic Keratosis." SKIN The Journal of Cutaneous Medicine 2 (December 17, 2018): S75. http://dx.doi.org/10.25251/skin.2.supp.75.

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15

Nandakumar, Michael. "AKT question relating to therapeutics in skin disease." InnovAiT: Education and inspiration for general practice 8, no. 3 (2015): e23-e23. http://dx.doi.org/10.1177/1755738015570796.

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16

Roustit, Matthieu, Sophie Blaise, and Jean-Luc Cracowski. "Trials and tribulations of skin iontophoresis in therapeutics." British Journal of Clinical Pharmacology 77, no. 1 (2013): 63–71. http://dx.doi.org/10.1111/bcp.12128.

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17

Thebar, Dr Jagdish, Dr Pritiraj Kapoor Raika, and Dr Preeti Srivastav. "A homoeopathic approach to skin ulcer with therapeutics." International Journal of Homoeopathic Sciences 6, no. 4 (2022): 600–604. http://dx.doi.org/10.33545/26164485.2022.v6.i4i.717.

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18

Beiter, Kaylin, Christy Behnam, and Bridget Shields. "Recalcitrant Grover’s Disease Successfully Managed with Dupilumab and Naltrexone in a Middle-Aged Woman: A Case Study." SKIN The Journal of Cutaneous Medicine 7, no. 4 (2023): 891–95. http://dx.doi.org/10.25251/skin.7.4.7.

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Introduction: Grover’s disease, or transient acantholytic dermatosis, is a common benign papulovesicular disorder that often affects elderly men. It is typically managed with topical therapeutics in this population. We present here an uncommon case of Grover’s disease, occurring in a relatively younger patient, that was recalcitrant to typical therapeutics modalities. Case Report: A 45-year-old woman presented to our clinic with a several month history of discrete, pink, ill-defined pruritic papules on her torso with sparing of her extremities. Grover’s disease was diagnosed based on her clini

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19

Nicholas-Haizelden, Keir, Barry Murphy, Michael Hoptroff, and Malcolm J. Horsburgh. "Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products." Microorganisms 11, no. 8 (2023): 1899. http://dx.doi.org/10.3390/microorganisms11081899.

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Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays

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Carvalhaes, Cecilia G., Helio S. Sader, Dee Shortridge, Jennifer M. Streit, and Rodrigo E. Mendes. "1369. Oritavancin Activity Against Methicillin-Resistant S. aureus (MRSA) Isolates Causing Skin and Skin Structure Infections in US Hospitals (2017-2019)." Open Forum Infectious Diseases 8, Supplement_1 (2021): S770—S771. http://dx.doi.org/10.1093/ofid/ofab466.1561.

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Abstract Background MRSA remains an important cause of community-onset (CA) and nosocomial (NA)- SSSI. Oritavancin (ORI) is a lipoglycopeptide antibiotic with activity against S. aureus, including MRSA and multidrug-resistant (MDR) strains. ORI was approved for clinical use by the US FDA to treat ABSSSI with a single 1,200 mg infusion over 1 (Kimyrsa) or 3 (Orbactiv) hours. This study evaluated the activity of ORI against MRSA isolates causing SSSI from US medical centers. Methods A total of 3,792 S. aureus isolates were consecutively collected (1 per patient) from 31 medical centers in 2017-2

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21

Waghule, Tejashree, Vamshi Krishna Rapalli, Srividya Gorantla, et al. "Nanostructured Lipid Carriers as Potential Drug Delivery Systems for Skin Disorders." Current Pharmaceutical Design 26, no. 36 (2020): 4569–79. http://dx.doi.org/10.2174/1381612826666200614175236.

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Background: Skin diseases affect all the age groups of people and have an impact on patients’ physical, mental, and emotional status. Conventional topical preparation is limited with its efficacy due to low permeation, frequent application, and poor adherence to the therapy for prolong time. Objective: The objective of this review article is to address the emerging trends of nanotechnology derived lipidic carrier systems for an effective treatment for skin disorders. Methodology: Various research and review articles from reputed international journals were referred and compiled. Results and Di

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22

Kaur, Kirandeep, Amandeep Singh, and Gurmeet Singh. "Therapeutics perspectives of incredible probiotics." Pharmaspire 14, no. 04 (2022): 141–53. http://dx.doi.org/10.56933/pharmaspire.2022.14219.

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The health benefits provided by probiotics are a matter of exploration from last years. With the help of various mechanisms, a single probiotic can only be applicable for a certain clinical condition because a particular probiotic is effective against a specific disease. The information regarding the clinical data in various diseases is not sufficient. A literature search was performed by focusing on the mechanisms by which probiotics acting on various diseases, the safety of probiotics and clinical data which provide huge information regarding the efficacy and safety of probiotics. In case of

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23

Han, Haowei, and Brian Berman. "Clinical Management of Actinic Keratosis: Review and Update." SKIN The Journal of Cutaneous Medicine 6, no. 4 (2022): 274–85. http://dx.doi.org/10.25251/skin.6.4.1.

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Actinic keratosis is commonly seen in dermatology clinics. Age and chronic sun exposure are the essential risk factors for its pathogenesis. It is regarded as a premalignant lesion; hence, aggressive treatment is warranted. Abundant research has been published about overall management, however, extensive knowledge about actinic keratosis prevention, the cost, safety profile, and mechanism of the existing therapeutics are pivotal in optimal clinical care. In this review article, we hereby present several commonly used approaches in office settings and the current guidelines. Finally, we will di

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24

Singh, Apoorva, and Nimisha. "Novel Nanolipoidal Systems for the Management of Skin Cancer." Recent Patents on Drug Delivery & Formulation 14, no. 2 (2020): 108–25. http://dx.doi.org/10.2174/1872211314666200817115700.

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: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potentia

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25

Foldvari, Marianna, Shawn Babiuk, and Ildiko Badea. "DNA Delivery for Vaccination and Therapeutics Through the Skin." Current Drug Delivery 3, no. 1 (2006): 17–28. http://dx.doi.org/10.2174/156720106775197493.

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26

L. Nufer, Kaitlin, Miko Yamada, and Tarl W. Prow. "Current and Next Generation Topical Anti-Skin Cancer Therapeutics." Drug Delivery Letters 6, no. 1 (2016): 46–56. http://dx.doi.org/10.2174/2210303106666160506155402.

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W Prow, Tarl, Kaitlin L. Nufer, and Miko Yamada. "Current and Next Generation Topical Anti-Skin Cancer Therapeutics." Drug Delivery Letters 06, no. 999 (2016): 1. http://dx.doi.org/10.2174/2210303106666161013114128.

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28

Lee, Ju Hee, and David E. Fisher. "Melanocyte stem cells as potential therapeutics in skin disorders." Expert Opinion on Biological Therapy 14, no. 11 (2014): 1569–79. http://dx.doi.org/10.1517/14712598.2014.935331.

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29

Petit, Robert Gironés, Amanda Cano, Alba Ortiz, et al. "Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics." International Journal of Molecular Sciences 22, no. 9 (2021): 4983. http://dx.doi.org/10.3390/ijms22094983.

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Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies de

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30

Ha, Dae Hyun, Hyun-keun Kim, Joon Lee, et al. "Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration." Cells 9, no. 5 (2020): 1157. http://dx.doi.org/10.3390/cells9051157.

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Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication. With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the characteristics of producer cells, exosomes can be utilized as cell-free therapeutics. Among exosomes derived from various cellular origins, mesenchymal stem cell-derived exosomes (MSC-exosomes) have gained great attention due to their immunomodulatory and regenerative functions. Indeed, many studies have shown anti-inflammatory, anti-aging and wound healing effects of MSC-exosomes in various in vitro and in vivo mode

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31

Alimardani, Vahid, Samira Sadat Abolmaali, Gholamhossein Yousefi, et al. "Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics." Journal of Clinical Medicine 10, no. 2 (2021): 181. http://dx.doi.org/10.3390/jcm10020181.

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Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule therapeutic agents but can also impart control over drug release or target impaired tissue. Thanks to their unique optical, photothermal, and superparamagnetic features, NPs have been also utilized for the treatment of skin disorders, imaging, and biosensing applications. Despite the widespread transdermal applications of NPs, their delivery across the stratum corneum, which is the main skin barrier, has remained challengi

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32

Zoltan, Samantha, and Nanette Silverberg. "Representation and Quality of Acne-Related Content on Social Media." SKIN The Journal of Cutaneous Medicine 9, no. 1 (2025): 2145–48. https://doi.org/10.25251/skin.9.1.19.

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Acne is a common dermatological condition affecting individuals of all races and ethnicities, with most cases occurring in teenagers and young adults. Patients in these age groups frequently turn to online platforms for guidance, relying on videos on social media platforms like TikTok. This study evaluated the top TikTok videos' content quality (DISCERN score) about perceived racial/ ethnic diversity. Findings demonstrate that videos showcasing the skin of individuals of color tend to have lower scientific content and potentially feature the application of agents that would promote dyspigmenta

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33

Yeh, Elizabeth S. "Special Issue: Cancer Metastasis and Therapeutic Resistance." Biomedicines 11, no. 5 (2023): 1347. http://dx.doi.org/10.3390/biomedicines11051347.

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Metastasis and resistance to cancer therapeutics are critical barriers to curing cancer. This special issue entitled “Cancer Metastasis and Therapeutic Resistance” contains nine original contributions. The articles span a variety of human cancers, including breast, lung, brain, prostate, and skin and touch upon significant areas of interest such as cancer stem cell function, cancer immunology, and glycosylation.

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Ebata, Satoshi, Asako Yoshizaki-Ogawa, Shinichi Sato, and Ayumi Yoshizaki. "New Era in Systemic Sclerosis Treatment: Recently Approved Therapeutics." Journal of Clinical Medicine 11, no. 15 (2022): 4631. http://dx.doi.org/10.3390/jcm11154631.

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Systemic sclerosis (SSc) is a chronic autoimmune disease with a poor prognosis. Among the various complications of SSc, treatment options for the fibrotic lesions, skin sclerosis, and SSc-associated interstitial lung disease (SSc-ILD) have been limited. However, since 2019, the efficacy and safety of nintedanib, tocilizumab, and rituximab for SSc or SSc-ILD have been demonstrated in double-blind, randomized, placebo-controlled trials, respectively. The antifibrotic agent nintedanib was approved for SSc-ILD in all regions of the United States, Europe, and Japan after the SENSCIS study confirmed

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35

Han, Li, Carlos P. Jara, Ou Wang, et al. "Isolating and cryopreserving pig skin cells for single-cell RNA sequencing study." PLOS ONE 17, no. 2 (2022): e0263869. http://dx.doi.org/10.1371/journal.pone.0263869.

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The pig skin architecture and physiology are similar to those of humans. Thus, the pig model is very valuable for studying skin biology and testing therapeutics. The single-cell RNA sequencing (scRNA-seq) technology allows quantitatively analyzing cell types, compositions, states, signaling, and receptor-ligand interactome at single-cell resolution and at high throughput. scRNA-seq has been used to study mouse and human skins. However, studying pig skin with scRNA-seq is still rare. A critical step for successful scRNA-seq is to obtain high-quality single cells from the pig skin tissue. Here w

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36

Mande, Purvi, Susmita Borthakur, Daniel Rios, et al. "Treatment of Autoimmune and Inflammatory Skin Diseases Using Skin-Targeting Bifunctional Antibodies: A Localized Immunomodulation Approach." Journal of Immunology 206, no. 1_Supplement (2021): 66.11. http://dx.doi.org/10.4049/jimmunol.206.supp.66.11.

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Abstract Current treatment approaches for autoimmune conditions comprise primarily of systemic immunosuppressants or cytokine blockade. Concentration of therapeutic molecules to the tissues that are the sites of autoimmune and inflammatory diseases is a promising approach with the potential to induce therapeutic benefit and avert risks associated with systemic immunotherapies. Pandion Therapeutics is developing a bifunctional antibody platform that can drive localized immune modulation. The platform combines a “tether antibody” that targets a tissue of choice and “an effector end” that activat

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37

Li, Yuehan. "Advancements, Challenges, and Future Directions of Stem Cell Therapies in Skin Cancer." Highlights in Science, Engineering and Technology 74 (December 29, 2023): 802–8. http://dx.doi.org/10.54097/pqa89q67.

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Skin cancer, one of the most prevalent malignancies worldwide, remains a significant challenge for global healthcare systems. Despite the availability of numerous treatments, many patients face suboptimal outcomes and a range of adverse effects. In the quest for more effective therapeutic strategies, attention has turned to stem cells, renowned for their unique ability to differentiate and regenerate. These attributes position them as potential game-changers in skin cancer therapeutics. This comprehensive review delves into the multifaceted world of skin stem cells, exploring their diverse typ

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Dzurová, Lenka, Edita Holásková, Hana Pospíšilová, Gabriela Schneider Rauber, and Jitka Frébortová. "Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation." Antibiotics 14, no. 1 (2024): 1. https://doi.org/10.3390/antibiotics14010001.

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Cathelicidins are a group of cationic, amphipathic peptides that play a vital role in the innate immune response of many vertebrates, including humans. Produced by immune and epithelial cells, they serve as natural defenses against a wide range of pathogens, including bacteria, viruses, and fungi. In humans, the cathelicidin LL-37 is essential for wound healing, maintaining skin barrier integrity, and combating infections. Cathelicidins of different origins have shown potential in treating various skin conditions, including melanoma, acne, and diabetic foot ulcers. Despite their promising ther

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Farhana, Aisha. "Enhancing Skin Cancer Immunotheranostics and Precision Medicine through Functionalized Nanomodulators and Nanosensors: Recent Development and Prospects." International Journal of Molecular Sciences 24, no. 4 (2023): 3493. http://dx.doi.org/10.3390/ijms24043493.

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Skin cancers, especially melanomas, present a formidable diagnostic and therapeutic challenge to the scientific community. Currently, the incidence of melanomas shows a high increase worldwide. Traditional therapeutics are limited to stalling or reversing malignant proliferation, increased metastasis, or rapid recurrence. Nonetheless, the advent of immunotherapy has led to a paradigm shift in treating skin cancers. Many state-of-art immunotherapeutic techniques, namely, active vaccination, chimeric antigen receptors, adoptive T-cell transfer, and immune checkpoint blockers, have achieved a con

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Malinowska, Magdalena Anna, Elżbieta Sikora, Joanna Stalińska, Jan Ogonowski, and Justyna Drukała. "The Effect of the New Lupeol Derivatives on Human Skin Cells as Potential Agents in the Treatment of Wound Healing." Biomolecules 11, no. 6 (2021): 774. http://dx.doi.org/10.3390/biom11060774.

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Skin barrier damage can be the result of various external factors including heat, radiation, chemicals and many others. Any interruption of the skin barrier integrity causes the exposure of the organism to harmful environmental factors. Therefore, there is an urgent need to develop novel therapeutics characterized by high bioavailability and effectiveness in skin damage recovery. Birch bark is known as a clinically proven, traditional medicinal remedy to accelerate wound healing. Lupeol, one of the main birch bark ingredients, shows a wide range of biological activity beneficial to the skin. T

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Amanulla, Khan, and Hafiz Aysha. "Medicinal Perspective and Therapeutics Studies on Gloriosa superba." International Journal of Emerging Technologies and Innovative Research 3, no. 3 (2023): 16–20. https://doi.org/10.5281/zenodo.7804131.

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Gloriosa superba Linn., an glorious herbaceous climber belongs to the family Liliaceae found throughout India/ Gloriosa superba are having various medicinal important. The current work is based on the medicinal perspectives and therapeutically valves of the plant in Ayurvedic, Unani nand Shiddha filed of medicine. Plant is reported for the treatment by many formulations such as, shotha (inflammation / oedema), vrana (wound), gandamala (lymphadinitis), charmaroga (skin diseases), khalitya (hair loss), agnimandya (loss of apettite), arsha (piles), vatavyadhi (joint pain / arthritis) and many oth

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Wang, Yibing, Rebecca Edelmayer, Joe Wetter, et al. "Macrophages play a pathogenic role in IL-23 mediated psoriasiform skin inflammation." Journal of Immunology 198, no. 1_Supplement (2017): 127.11. http://dx.doi.org/10.4049/jimmunol.198.supp.127.11.

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Abstract Psoriasis (Ps) is an immune-mediated inflammatory skin disease that affects millions worldwide. Studying immune cells involved in Ps pathogenesis is essential to identify effective and safe therapeutics for the disease. Recent studies have demonstrated the involvement of macrophages in human Ps skin. Using an IL-23 murine model of psoriasiform dermatitis, which closely models human Ps, we have characterized the cellular lineage during disease progression and found continuous infiltration of macrophage as dominant immune population. Depletion of macrophages in the IL-23 murine model si

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Bani, Kamal Singh, and Khushboo Bhardwaj. "Topical Drug Delivery Therapeutics, Drug Absorption and Penetration Enhancement Techniques." Journal of Drug Delivery and Therapeutics 11, no. 4 (2021): 105–10. http://dx.doi.org/10.22270/jddt.v11i4.4864.

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The delivery of medications through the skin has long been a fascinating as well as difficult subject of study. For different medications, topical drug administration has brought substantial benefits over the systemic route, one of the most important of which is reduced toxicity due to minimal or no exposure to non-target organs. Because of its simplicity and affordability, topical administration is the preferred method for delivering medicinal substances locally. Topical drug delivery system includes solid powders, semisolids, liquid preparations, and sprays, among other pharmaceutical dose f

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Varshini, Y* Satish S. "Revolutionizing Therapeutics: A Comprehensive Review On Clinical Approach Innovations In Drug Delivery Systems." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 604–16. https://doi.org/10.5281/zenodo.10423901.

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  The skin offers an accessible & convenient site for the administration of medication. The transdermal drug delivery system has been a safe &effective drug delivery system, it aims to deliver the drug through the skin at a predetermined rate and controlled rate. If a drug has the right mix of physical chemistry and pharmacology, transdermal delivery is a remarkably effective route of administration. The transdermal patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose & medication through the skin & into the bloodstream. Often, this pro

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Langley, Richard G., Aditya K. Gupta, Andrea M. Cherman, and Kimberley A. Inniss. "Biologic Therapeutics in the Treatment of Psoriasis. Part 2: Practical Considerations." Journal of Cutaneous Medicine and Surgery 11, no. 4 (2007): 145–49. http://dx.doi.org/10.2310/7750.2006.00060b.

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Background: Psoriasis is a chronic inflammatory skin disease principally mediated by activated T cells, which release proinflammatory cytokines with reactive epidermal changes in the skin, producing the characteristic lesions of psoriasis. New research into possible treatment options has been inspired by increased understanding of the pathophysiology of psoriasis and advances in immunology and molecular biology permitting the development of targeted, highly active biologic agents. Objective: The aim of this article is to provide practical guidelines for integration of these agents in the manag

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Ferček, Iva, Liborija Lugović-Mihić, Arjana Tambić-Andrašević, et al. "Features of the Skin Microbiota in Common Inflammatory Skin Diseases." Life 11, no. 9 (2021): 962. http://dx.doi.org/10.3390/life11090962.

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Abstract (sommario):

Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term “microbiome” comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are belie

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Jabs, Hans-Ulrich. "Exosomes in Dermatological Aesthetics & Cosmetic Skin Care." Clinical Dermatology & Therapy 10, no. 2 (2024): 1–3. https://doi.org/10.24966/cdt-8771/100147.

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Abstract (sommario):

Exosomes, tiny membrane-bound vesicles, play a crucial role in cell-to-cell communication and are of great interest as therapeutics in dermatological aesthetics and skin care. This article provides an overview of their origin, function, and cosmetic applications in skin care.

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Yook, Hwa Jung, and Ji Hyun Lee. "Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics." International Journal of Molecular Sciences 25, no. 10 (2024): 5164. http://dx.doi.org/10.3390/ijms25105164.

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Abstract (sommario):

Chronic pruritus that lasts for over 6 weeks can present in various forms, like papules, nodules, and plaque types, with prurigo nodularis (PN) being the most prevalent. The pathogenesis of PN involves the dysregulation of immune cell–neural circuits and is associated with peripheral neuropathies, possibly due to chronic scratching. PN is a persistent and challenging condition, involving complex interactions among the skin, immune system, and nervous system. Lesional skin in PN exhibits the infiltration of diverse immune cells like T cells, eosinophils, macrophages, and mast cells, leading to

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Faizan, Khan1 Surendra Dangi*2 Dr. Bhaskar Kumar Gupta3. "Review on Nanoparticle-Based Creams: Formulation, Characterization, and Applications in Therapeutics." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 3049–54. https://doi.org/10.5281/zenodo.15280634.

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Abstract (sommario):

Nanoparticle-based creams have emerged as a promising advancement in the field of pharmaceutical and cosmetic formulations due to their ability to enhance drug delivery, improve skin penetration, and provide sustained release of active ingredients. This review explores the formulation strategies, characterization techniques, and therapeutic applications of nanoparticle creams. Various types of nanoparticles, including liposomes, solid lipid nanoparticles (SLNs), and polymeric nanoparticles, are discussed in terms of their advantages, challenges, and suitability for topical application. Additio

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Liu, Jiahua, Runzi Zheng, Yanghuan Zhang, Shuting Jia, Yonghan He, and Jing Liu. "The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies." Cancers 15, no. 9 (2023): 2640. http://dx.doi.org/10.3390/cancers15092640.

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Abstract (sommario):

Melanoma is a malignant skin tumor that originates from melanocytes. The pathogenesis of melanoma involves a complex interaction that occurs between environmental factors, ultraviolet (UV)-light damage, and genetic alterations. UV light is the primary driver of the skin aging process and development of melanoma, which can induce reactive oxygen species (ROS) production and the presence of DNA damage in the cells, and results in cell senescence. As cellular senescence plays an important role in the relationship that exists between the skin aging process and the development of melanoma, the pres

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