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Tesi sul tema "Therapeutic target identification"

Autore: Grafiati
Pubblicato: 16 novembre 2024
Ultima modifica: 25 luglio 2025

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1

Park, Jong Kook. "Target Identification, Therapeutic Application and Maturation Mechanism of microRNAs." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1331096696.

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2

Cheung, Chi-ho, and 張志豪. "Identification of CD47 as a novel therapeutic target for hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46945374.

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3

Hendley, Rhiannon. "Identification of Lyn kinase as a therapeutic target for tamoxifen resistant breast cancer." Thesis, Cardiff University, 2012. http://orca.cf.ac.uk/31462/.

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Abstract (sommario):
Tamoxifen has made a significant contribution in decreasing breast cancer related deaths for over 30 years and until recently was the gold standard for treatment of ER positive breast cancer (Fisher et al, 1998). Resistance to tamoxifen is however a considerable issue with cells utilising a number of molecular mechanisms to bypass the growth inhibition caused by blocking ER activity. This move towards an anti-hormone resistant state from an antihormone responsive state is associated with the transition to a much more aggressive phenotype including increased proliferation and also invasiveness.
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4

Paudel, Nirmala. "Computational analysis of biochemical networks for drug target identification and therapeutic intervention design." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90152.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 96-104).<br>Identification of effective drug targets to intervene, either as single agent therapy or in combination, is a critical question in drug development. As complexity of disease like cancer is revealed, it has become clear that a holistic network approach is needed to identify drug targets that are specially positioned to provide desired leverage on disease phenotypes. In this thesis we develop a comput
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5

BENINI, MONICA. "Identification of the frataxin-specific E3 ligase as a potential therapeutic target for Friedreich’s Ataxia." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/203003.

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Friedreich’s ataxia (FRDA) is a rare debilitating, life-shortening, autosomal recessive inherited disease that leads to progressive damage to the nervous system. Onset is usually around the puberty and patients develop a progressive loss of motor coordination, inability to walk, slurred speech, and a cardiac hypertrophy that often leads to premature death. The particular genetic mutation – expansion of an intronic GAA triplet repeat in the FXN gene – leads to reduced expression of the mitochondrial protein frataxin involved in iron-sulfur cluster biogenesis. The subsequent frataxin insufficien
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6

TRICARICO, PAOLA MAURA. "Mevalonate Kinase Deficiency: identification of new therapeutic target, in vitro and in vivo pathogenic study." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908002.

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Il Difetto di Mevalonato Chinasi (MKD) è una malattia rara autoinfiammatoria autosomica recessiva, causata da mutazioni nel gene MVK che codifica per mevalonato chinasi (MK), enzima chiave della via del mevalonato. Questa via è importante per la produzione di colesterolo, ed anche geranilgeranil pirofosfato e farnesil pirofosfato essenziali per la prenilazione delle proteine. MKD ha fenotipi clinici eterogenei, infatti, si va da una forma lieve, la sindrome iper-IgD (HIDS), ad una forma più grave, la Mevalonica Aciduria (MA). HIDS è caratterizzata da sintomi eterogenei che comprendono febbri r
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7

Hoppe, Stephanie [Verfasser], and Martin [Akademischer Betreuer] Müller. "Identification of target T cell epitopes for a therapeutic HPV16 vaccine / Stephanie Hoppe ; Betreuer: Martin Müller." Heidelberg : Universitätsbibliothek Heidelberg, 2019. http://d-nb.info/1177043491/34.

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8

Slim, Lotfi. "Detection of epistasis in genome wide association studies with machine learning methods for therapeutic target identification." Thesis, Université Paris sciences et lettres, 2020. https://pastel.archives-ouvertes.fr/tel-02895919.

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En offrant une image sans précédent du génome humain, les études d'association pangénomiques (GWAS) expliqueraient pleinement le contexte génétique des maladies complexes. A ce jour, les résultats ont été pour le moins mitigés. Cela peut être partiellement attribué à la méthodologie statistique adoptée, qui ne prend pas souvent en compte l'interaction entre les variants génétiques, ou l'épistasie. La détection d'épistasie à travers des modèles statistiques présente plusieurs défis pour lesquels nous développons dans cette thèse une paire d'outils adéquats. Le premier outil, epiGWAS, utilise l'
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9

Maule, Francesca. "Identification of Annexin 2A as a fundamental mediator of glioblastoma cell dissemination and potential therapeutic target." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3422285.

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Glioblastoma multiforme (GBM) is the most devastating tumor of the brain, characterized by an almost inevitable tendency to recur after intensive treatments and a fatal prognosis. Indeed, despite recent technical improvements in GBM surgery, the complete eradication of cancer cell disseminated outside the tumor mass still remains a crucial issue for glioma patients management. In my PhD project, we identified Annexin 2A (ANXA2) as an important intracellular cytoskeletal protein expressed also on the surface of various types of cancer cells. Initially, we show that ANXA2 is over-expressed in IV
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10

Cole, Clare Louise. "Identification of OATP1B3 as a potential therapeutic target in Recessive Dystrophic Epidermolysis Bullosa Associated Squamous Cell Carcinoma." Thesis, University of Dundee, 2011. https://discovery.dundee.ac.uk/en/studentTheses/20729995-be96-4f29-80b8-53da131c6fd8.

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Epidermolysis Bullosa encompasses a group of inherited heterogeneous diseases involving trauma induced blistering of the skin. Recessive Dystrophic Epidermolysis Bullosa (RDEB) is one of the most debilitating variants of the disease and patients are predisposed to developing aggressive cutaneous Squamous Cell Carcinoma (SCC). Unlike SCC in the general population, the primary cause of RDEB associated SCC is not UV-radiation. SCC in RDEB patients has poor prognosis due to a high frequency of recurrence and metastasis. 70% of all severe generalized RDEB patients die from SCC by the age of 45, com
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11

Pandiani, Charlotte. "Étude et identification des états transcriptionnels dans le mélanome uvéal primaire." Electronic Thesis or Diss., Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ6012.

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Le mélanome uvéal (MU) est la tumeur intraoculaire la plus fréquente chez l’adulte. C’est une tumeur agressive qui dérive de la transformation maligne des mélanocytes. Les traitements du MU primaire reposent sur des techniques de radiothérapies, et sur la chirurgie. Malgré le succès du traitement primaire, plus de 50% des patients développent des métastases qui vont principalement envahir le foie, suggérant l’existence d’une sous-population cellulaire, responsable de la dissémination métastatique. Il n’existe aujourd’hui aucun traitement systémique pour soigner le MU métastatique. A ce stade,
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12

Toulmonde, Maud. "Analyse Intégrée génomique, protéomique et radiomique des Sarcomes Pléomorphes Indifférenciés : Identification et Validation de nouvelles cibles thérapeutiques." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0429.

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Les Sarcomes indifférenciés pléomorphes (UPS pour Undifferentiated Pleomorphic Sarcoma) forment un groupehétérogène « par défaut ». Nous avons émis l’hypothèse qu’il existe un lien entre le niveau de dédifférenciation des UPS et l’infiltrat immun intra-tumoral, et que cette relation repose sur des altérations génomiques ainsi que sur l’activation de voies de signalisation spécifiques associées à un impact thérapeutique potentiel. Les objectifs de ce travail étaient de générer une classification des UPS intégrant une approche génomique, immunophénotypique, protéomique et radiomique, et d’identi
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13

Ferguson, Henry John Murray. "The identification and validation of GRIN2D as a novel endothelial target in colorectal cancer, and the investigation of its effects as a therapeutic tumour vaccine." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6167/.

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A shortlist of candidate tumour endothelial markers was generated by Microarray comparison of differential gene expression between multiple patient-matched colorectal cancer and normal colon samples. This list was narrowed through a process of literature review, real-time quantitative polymerase chain reaction and immunohistochemistry. Through siRNA knockdown and analysis in in vitro models of angiogenesis, it has been demonstrated that a decrease in an novel target’s expression significantly decreases cellular migration, communication and chemotaxis, without adversely affecting cell viability
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14

De, Giorgio Maria Rita. "IDENTIFICATION AND CHARACTERIZATION OF NOVEL SIGNALS REGULATING FEEDING BEHAVIOR AND ENERGY BALANCE. Evidences indicating TFF2 as a novel potential therapeutic target for diet-induced obesity treatment." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/29006/29006.pdf.

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15

Alfar, Ezzaldin Ahmed [Verfasser], Kaomei [Gutachter] Guan, and Christopher [Gutachter] Antos. "Cardiac molecular defects in an in vitro disease model of Vici syndrome and identification of potential therapeutic target / Ezzaldin Ahmed Alfar ; Gutachter: Kaomei Guan, Christopher Antos." Dresden : Technische Universität Dresden, 2020. http://d-nb.info/1227832915/34.

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16

De, Giorgio Maria Rita. "Identification and charcterization of novel signals regulating feeding behavior and energy balance : evidences indicating TFF2 as a novel potential therapeutic target for diet-induced obesity treatment." Doctoral thesis, Université Laval, 2012. http://hdl.handle.net/20.500.11794/23739.

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Abstract (sommario):
La recherche dans le domaine de l'obésité a énormément progressé pendant les dernières décennies et a apporté une contribution fondamentale à la compréhension des mécanismes biologiques et physiologiques impliqués, de même que leurs interactions avec l'environnement obésogène. Les études génétiques et génomiques ont mis en évidence les traits héréditaires majeurs qui peuvent causer ou prédisposer à l'accumulation excessive de gras corporel et ils ont stimulé la caractérisation de nombreux gènes codant pour des protéines impliquées dans la physiologie du bilan énergétique. Malgré le progrès con
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17

ZANNOTTI, ALESSANDRO. "Leiomyoma and leiomyosarcoma two different pathologies with the same origin: identification of a possible new marker and therapeutic target through characterization of Raf kinase inhibitor protein (RKIP)." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/306139.

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Leiomiosarcoma maligno e leiomioma benigno rappresentano le due controparti della trasformazione del miometrio. Tuttavia la diagnosi differenziale per discriminare tra lesioni benigne e maligne rappresenta un grande problema. Così vanno identificati nuovi markers per rendere la diagnosi differenziale piu’ accurata. Il ruolo pleiotropico dell’RKIP nel leiomiosarcoma non è ancora chiaro. In questa tesi tramite l’immunoistochimica si sono riscontrate la tendenza di cinque diverse varianti istologiche di lesioni benigne a essere positive all’RKIP e, al contrario, la tendenza delle lesioni maligne
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18

Diekhoff, Svenja Verfasser], Ansgar [Akademischer Betreuer] Büschges, Gereon R. [Akademischer Betreuer] [Fink, and Christian [Akademischer Betreuer] Grefkes. "Transcranial magnetic stimulation combined with functional magnetic resonance imaging : From target identification to prediction of therapeutic effects in stroke patients / Svenja Diekhoff. Gutachter: Ansgar Büschges ; Gereon Fink ; Christian Grefkes." Köln : Universitäts- und Stadtbibliothek Köln, 2011. http://d-nb.info/1038111811/34.

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19

Guca, Ewelina. "Caractérisation structurale de la CTP : phosphocholine cytidylyltransférase de Plasmodium falciparum et identification de composés inhibiteurs basée sur la structure visant à cibler la voie de biosynthèse des phospholipides." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT077.

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À l’heure actuelle, le paludisme reste un problème de santé majeur et demeure une des maladies parasitaires les plus menaçantes. Parmi les cinq espèces de malaria infectant l’homme, Plasmodium falciparum est la forme la plus mortelle. Lors de la phase érythrocytaire de son cycle de vie, causant tous les symptômes du paludisme, P.falciparum utilise les phospholipides pour créer les membranes nécessaires au développement de cellules filles. Chez P. falciparum, la phosphatidylcholine est principalement obtenue grâce à la voie de synthèse de novo, dite voie de Kennedy. Dans cette voie de biosynthè
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20

Nassal, Michelle MJ. "Identification of novel therapeutic targets for reentrant arrhythmias." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1459508947.

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21

Fabrizi, Eros. "Identification of novel therapeutic targets for colon adenocarcinoma." Thesis, Universita' degli Studi di Catania, 2011. http://hdl.handle.net/10761/95.

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Abstract (sommario):
Colorectal cancer (CRC) is the third most common form of cancer in the Western world. Despite the emergence of new targeted agents and the use of various therapeutic combinations, none of the treatment options available is curative in patients with advanced cancer. A growing body of evidence is increasingly supporting the idea that malignancies originate from a small fraction of cancer cells, called Cancer Stem Cells (CSC), that show self-renewal and pluripotency and are capable of initiating and sustaining tumor growth. Several studies have shown that, with respect to the bulk of tumor
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22

Dutton-Regester, Ken. "The identification of therapeutic targets in metastatic melanoma." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53305/1/Ken_Dutton-Regester_Thesis_Final.pdf.

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Metastatic melanoma, a cancer historically refractory to chemotherapeutic strategies, has a poor prognosis and accounts for the majority of skin cancer related mortality. Although the recent approval of two new drugs combating this disease, Ipilimumab and Vemurafenib (PLX4032), has demonstrated for the first time in decades an improvement in overall survival; the clinical efficacy of these drugs has been marred by severe adverse immune reactions and acquired drug resistance in patients, respectively. Thus, understanding the etiology of metastatic melanoma will contribute to the improvement of
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23

Coste, Florence. "Nouvelles approches diagnostiques et thérapeutiques dans l'hypertension pulmonaire : apport de la tomodensitométrie et identification du facteur de croissance des nerfs NGF comme nouvelle cible thérapeutique." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0120/document.

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L’hypertension pulmonaire (HTP) est définie par une valeur de pression artérielle pulmonaire moyenne (PAPm) supérieure à 25 mmHg au repos. Il existe des formes sévères d’HTP (HTPs) avec des valeurs de PAPm encore plus élevées associées à des symptômes plus marqués et à l’apparition de lésions anatomo pathologiques spécifiques. Le diagnostic et le développement de nouvelles thérapies sont des enjeux majeurs pour une meilleure prise encharge de ces patients À l’aide de la tomodensitométrie, nos travaux observationnels chez l’homme atteint debroncho-pneumopathie chronique obstructive (BPCO) ont m
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24

Esmaeil, Shalaby A. A. "Molecular analysis of chordomas and identification of therapeutic targets." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/20213/.

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Chordoma is a rare malignant bone tumour, showing notochordal differentiation, which occurs in the axial skeleton. Brachyury, a molecule involved in notochordal development, is a highly specific and sensitive marker for chordoma. It is hypothesised that brachyury or genes involved in its activation are implicated in the pathogenesis of chordoma. As there is currently no effective drug therapy for chordoma the aim of this study was to identify genetic events involved in chordoma pathogenesis with a view to identifying potential therapeutic targets. One hundred chordomas (50 skull-based, 50 non-
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25

Correia, Patrícia Maria Dias. "Identification and characterization of potential therapeutic targets for spinal cord repair." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22055.

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Mestrado em Biomedicina Molecular<br>Traumatic spinal cord injury (SCI) is a devastating event that leads to loss of neurological functions below the vertebral level of the lesion. As adult neurons from central nervous system (CNS) fail to regenerate when injured, the consequences of SCI are partially or totally irreversible. The lack of regeneration ability of CNS neurons has been studied for years but still no effective treatment was found for this pathology; only steroids are validated and recognized as a pharmacologic treatment attempt, but just limit the lesion extent. This work fo
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26

Benajiba, Lina. "Identification and Characterization of New Therapeutic Targets in Acute Myeloid Leukemia." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS173.

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La leucémie aiguë myéloïde (LAM) est une pathologie hématologique dont le pronostic reste très défavorable, malgré les progrès réalisés dans la compréhension des mécanismes physiopathologiques sous-tendant son développement. Identifier de nouvelles stratégies anti-leucémiques représente donc une étape clé dans la concrétisation des avancées thérapeutiques. Grâce à la combinaison de plusieurs approches de criblage génétiques et pharmacologiques, l’objectif de ma thèse a été de définir et valider de nouvelles cibles thérapeutiques dans les LAM. La première partie de ma thèse a eu pour but de tra
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DE, SANTA JACOPO. "Identification of potential oncogenes as novel therapeutic targets by RNAi screening." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908009.

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Every year, more than one million of people worldwide are diagnosed with colorectal cancer (CRC). Even though preventive screenings have been able to reduce incidence and mortality, nearly half of the patients die following the diagnosis and the treatment. In particular, a not negligible part is due to recurrences after treatment, probably caused by a limited efficacy of the current therapies. To improve the therapeutic success and options, repositioned or new drugs and novel therapeutic targets should be taken in consideration. Moreover, in the last years, large cancer genome analyses projec
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28

Matula, Katarzyna Monika. "Evaluation of chemoresistance in oesophagogastric cancers : identification of candidate novel therapeutic targets." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=201696.

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Development of resistance is the major hindrance to successful chemotherapy treatment in oesophago-gastric (OEG) cancers. Platinum based chemotherapy prolong the survival however only 20 - 30 % of patients survive 5- years since diagnosis of the disease. Therefore understanding of the mechanisms that underlie this phenomenon and identification of novel biomarkers/targets that could predict the response to the treatment and sensitize these tumours to current therapy is needed. We established a panel of human cancer cell lines of oesophagus (OE21 and OE33) and gastric cardia (AGS) resistant to o
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29

Lin, Hanyang. "Identification and characterization of novel therapeutic targets and biomarkers in chronic myeloid leukemia." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58470.

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Chronic myeloid leukemia (CML) has long served as a paradigm for new insights into the cellular origin, pathogenesis and treatment of human cancers. ABL tyrosine kinase inhibitor (TKI) therapies have had remarkable effects on treatment of early phase CML. However, TKI monotherapies are not curative, and initial and acquired TKI resistance remain clinically challenging. Particularly, CML stem/progenitor cells are insensitive to TKIs. Therefore, novel treatments and predictive biomarkers are clearly needed. In this work, I studied the biological effects of dual BCR-ABL and JAK2 suppressions on T
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Shaw, Victoria. "Identification of anti-hormone induced genes as potential therapeutic targets in breast cancer." Thesis, Cardiff University, 2007. http://orca.cf.ac.uk/55672/.

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Tamoxifen, a competitive inhibitor of oestradiol binding to the oestrogen receptor ER, remains a key anti-hormonal treatment for ER ve breast cancer although its effectiveness is limited by development of resistance. It is hypothesised that in addition to blockade of pro-proliferative/anti-apoptotic genes, anti-oestrogens exert an early protective effect, inducing cell survival and pro-invasive genes that enable a subset of cells to escape the anti-tumour effects of the anti-oestrogens and facilitate disease progression. It was hoped that identification of such early compensatory events in thi
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Hopkins, Goitseone Lucy. "Identification of therapeutic targets in acute myeloid leukaemia expressing the mutant RAS oncogene." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/71839/.

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Mutational activation of RAS is one of the most common molecular abnormalities associated with acute myeloid leukaemia (AML). Normal human haematopoietic progenitor cells (HPC) expressing mutant RAS overproduce ROS due to NADPH oxidase (NOX) activation and this promotes the proliferation of these cells as well as AML blasts. The mechanisms by which ROS promote proliferation is however unclear. The current study investigated the effect of RAS-induced ROS production on gene expression in normal HPC using gene expression profiling (GEP) and assessed whether ROS-induced gene expression changes con
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Leruste, Amaury. "Immune context of malignant rhabdoid tumors : description and identification of new therapeutic targets." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS050.

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Les tumeurs rhabdoïdes (TR) constituent un rare cancer indifférencié du jeune enfant et du nourrisson, avec un âge médian au diagnostic de 20 mois. Ces tumeurs sont caractérisées par une inactivation biallélique du gène suppresseur de tumeur SMARCB1, un des membres du complexe SWI/SNF, acteur majeur du remodelage de la chromatine, sans autre altération génomique récurrente. Le pronostic des TR est péjoratif, le taux de survie globale atteignant 30% dans la plupart des séries, malgré des approches thérapeutiques conventionnelles particulièrement agressives. Les approches d’immunothérapies ont o
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Silva, Evangelista Cláudia. "Molecular Characterization of Pediatric Brainstem Gliomas (DIPG) and Identification of New Therapeutic Targets." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS269.

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Les DIPG représentent les tumeurs cérébrales pédiatriques les plus sévères. Aucun progrès dans leur prise en charge n’a été accompli au cours des 50 dernières années et la radiothérapie ne demeure que transitoirement efficace. Récemment, une mutation somatique de l’histone H3 (K27M) spécifique des DIPG a été trouvée chez environ 95% des patients. Elle est aujourd’hui considérée comme l'événement oncogénique initiateur de ces tumeurs. Deux sous-groupes majeurs de patients présentant des programmes oncogéniques et une réponse à la radiothérapie distincts peuvent être définis en fonction du gène
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34

Johansson, L. Gunnar. "Identification of Targeted Therapeutics for Malignant Peripheral Nerve Sheath Tumors." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1216841242.

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35

Chiang, Yan Ting. "Identification of metastasis-driving genes as potential therapeutic targets/ biomarkers for metastatic prostate cancer." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/52901.

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Metastatic prostate cancer is currently incurable. Metastasis is thought to result from changes in the expression of specific metastasis-driving genes, leading to a cascade of activated downstream genes setting the metastatic process in motion. As such, metastasis-driving genes could provide effective therapeutic targets and prognostic biomarkers for improved disease management. In search of potential metastasis-driving genes, genes with elevated expression in patient-derived metastatic LTL-313H prostate cancer tissues, as distinct from non-metastatic LTL-313B tissues, were identified. Among t
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36

D'Costa, Z. C. "The identification of novel therapeutic targets for the treatment of TBX2-driven breast cancers." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546040.

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37

Macaire, Héloïse. "Régulation de l’expression des protéines anti-apoptotiques Bfl-1 et Bcl-xL par les protéines virales Tax et HBZ du virus HTLV-1 et identification de petites molécules anti-Bfl-1 à visée thérapeutique." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10357/document.

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Le virus humain T lymphotrope de type 1 (HTLV-1) est l’agent étiologique de la leucémie/lymphome T de l’adulte (ATLL) qui se développe après plusieurs décennies et pour laquelle il n’existe à ce jour pas de traitement efficace. Parmi les protéines virales de HTLV-1, Tax et HBZ jouent un rôle déterminant dans le développement de l’ATLL. Si Tax participe au processus leucémogène dès les étapes précoces, HBZ jouerait plutôt un rôle dans le maintien du phénotype tumoral dans les étapes tardives. Dans ce contexte, là nous nous sommes intéressés à la régulation de l’expression des protéines anti-apo
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van, Delft Frederik Willem. "Microarray analysis of childhood leukaemia; its use in diagnosis, classification and identification of therapeutic targets." Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499811.

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Saito-Benz, Hideshiro. "Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61231.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, June 2009.<br>"April 2009." Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Tamoxifen resistance is the biggest problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome and unresponsiveness to endocrine treatment. Although much work has been done over the past decades to elucidate pathways involved in HER2 receptor signaling, the map of network-wi
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Russo, Giulia. "Novel computational strategies for the identification of new therapeutic targets in melanoma and thyroid cancer." Doctoral thesis, Università di Catania, 2018. http://hdl.handle.net/10761/4157.

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Cancer signaling pathways have been extensively investigated. However, how cross-talk processes and integrates pathway responses in cancer is still far from being completely elucidated. Genetic and epigenetic alterations lead cells to aberrant proliferation and escapement from physiological mechanism controlling cell growth, survival and migration. In this context, specific mutations transform cellular proto-oncogenes to oncogenes, triggering hyperactivation of signaling pathways, whereas inactivation of tumor suppressors removes critical negative regulators of signaling. MAPK and PI3K/AKT pat
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Bretones, Santamarina Jorge. "Integrated multiomic analysis, synthetic lethality inference and network pharmacology to identify SWI/SNF subunit-specific pathway alterations and targetable vulnerabilities." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL049.

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De nos jours, la communauté scientifique s'accorde sur la nécessité de diagnostics et de thérapies personnalisés pour les patients atteints de cancer, conçus par des études translationnelles combinant approches expérimentales et statistiques. Les défis actuels incluent la validation de modèles expérimentaux précliniques et leur profilage multi-omiques, ainsi que la conception de méthodes bioinformatiques et mathématiques dédiées pour identifier les combinaisons de médicaments optimales pour chaque patient.Cette thèse a visé à concevoir de telles approches statistiques pour analyser différents
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Haslett, Luke. "Lysosomal storage disorders and neurodegenerative disease : related mechanisms of pathogenesis and identification of novel therapeutic targets." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/89191/.

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Lysosomal storage disorders (LSDs) are rare diseases caused by inherited mutations in genes coding for proteins of the endolysosomal system. The lysosome is an organelle responsible for the degradation of dysfunctional organelles and for the catabolism, and subsequent recycling, of macromolecules within the cell. When this process becomes defective the substrates of lysosomal catabolism accumulate; these can include lipids, proteins, polysaccharides, nucleotides and diverse combinations of all three. The phenotypic spectrum of these diseases in isolation, and even more so as a group, is extrem
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Alebady, Zainab Adnan Hatem. "Gene expression profiles and biomarker identification for KMT5A identifies novel potential therapeutic targets in prostate cancer." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3835.

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Prostate cancer (PC), is initially androgen dependent due to the androgenic nature of the organ. Hence, initial therapy comprises androgen depletion via chemical castration in conjunction with an anti-androgen therapeutic. However, patients relapse and the tumours aggressively re-grow in a castrate resistant (CRPC) manner. In CRPC, androgen receptor (AR) signaling remains functional via numerous mechanisms hence the AR remains a viable therapeutic target. However, treatment with current AR targeting therapeutics also results in relapse indicating the potential of targeting AR signaling indirec
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Tzelepis, Konstantinos. "Identification of novel genetic vulnerabilities and therapeutic targets in acute myeloid leukaemia using CRISPR dropout screens." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/271130.

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Acute myeloid leukaemia (AML) is an aggressive cancer with a poor prognosis, for which mainstream treatments have not changed for decades. To identify novel therapeutic targets in AML, I have optimized a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screening platform and use it to identify genetic vulnerabilities in AML cells. This work led to the identification of 492 AML-specific cell-essential genes, including several established therapeutic targets such as that represent new clinically actionable candidates. I have validated selected genes using DOT1L, BCL
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Akarca, Ayse. "Immunohistochemical studies for identification of biomarkers in haematological malignancies: An approach for potential novel therapeutic targets." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1127626.

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Lymphoid neoplasms are a subgroup of haematological malignancies that affect circulating lymphocytes. The clinical and biological heterogeneity of lymphoid neoplasms can lead to difficulty in accurate diagnosis in this group of diseases. The advancement in effective and feasible detection platforms has enabled novel biomarkers to improve diagnosis and prognosis, in addition to assist in patient stratification and personalised treatments for these diseases. Although there have been improvements in high-throughput diagnostic techniques, the conventional immunohistochemistry (IHC) remains the mos
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PARISI, ERICA. "Immune response against Wilms Tumor: characterization of cellular and molecular interactions and identification of novel therapeutic targets." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1078738.

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Wilms tumor (WT) is a pediatric kidney tumor that accounts for 6-7% of children’s malignant tumors. WT cells arise from embryonic mesenchymal renal progenitors, not differentiated, remaining in the organ after birth. The classic triphasic WT contains a mixture of undifferentiated blastemal, differentiated epithelial cells, and stromal elements, whereas individual cell types may predominate in some tumors. Moreover, as human mesenchymal stem cells (MSCs), these cells have the ability to differentiate in many tissue lineages. In particular, stromal-like WT (str-WT) display morphological, phenoty
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Bazzocco, Sarah. "Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/350805.

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Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes and oncogenes is far from complete, even in the case of the tumor types that are best characterized, such as colorectal cancer. Colorectal cancer is the second most frequent cause of cancer-related death in the Western world and is a serious health issue for the European Union. Patients having stage III or IV cancer undergo surgery followed by chemotherapy. However, the cli
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Ikromov, Odiljon [Verfasser]. "Pharmacological reactivation of epigenetically regulated genes for identification of therapeutic targets and putative biomarkers in prostate cancer / Odiljon Ikromov." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2015. http://d-nb.info/1068208937/34.

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Caligiuri, Stephanie. "The reduction of hypertension through dietary flaxseed intervention and the identification of oxylipins as therapeutic targets in cardiovascular disease." Springer, 2014. http://hdl.handle.net/1993/31589.

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Dietary flaxseed is a Manitoban crop rich in the n3 fatty acid alpha-linolenic acid, fibre and antioxidant lignans. Addition of flaxseed to the diet decreased brachial blood pressure in patients with hypertension and peripheral artery disease over one year (n=110). With the addition of flaxseed to standard of care, 21% of patients improved from blood pressure above goal (>140/90 mmHg) to blood pressure within goal (<140/90 mmHg). Dietary flaxseed may have induced these anti-hypertensive effects through the reduction of vascular constriction and inflammation. Healthy older adults, who consumed
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Szczesna, Karolina. "Identification of novel therapeutic targets and evaluation of pharmacological treatments in epigenetic and chromatin diseases- the case of Rett syndrome." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/312826.

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INTRODUCTION: In 1966, Rett syndrome (RTT, OMIM#312750) was for the first time described as a clinical issue by Dr. Andreas Rett, an Austrian pediatrician. He has observed in 22 patients similar unique symptoms. A few years later Hagberg and colleagues described further the syndrome in 35 girls. Rett syndrome is the cause of mental retardation that affects 1 in 10.000 female births, which makes it the second cause of mental retardation in girls. In 1999 Zoghbi lab found out the genetic basis of Rett disease. Mutation in MeCP2 is in 95% cases the reason of classical Rett. MeCP2 is a nu
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