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Letteratura scientifica selezionata sul tema "Thomas College"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 febbraio 2022

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Articoli di riviste sul tema "Thomas College"

1

White, Harvey. "Sir Thomas Browne and Winchester College". Journal of Medical Biography 2, n. 2 (maggio 1994): 120–21. http://dx.doi.org/10.1177/096777209400200212.

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2

Khanenko-Friesen, Natalia, e Darrell McLaughlin. "Conversation with Darrell McLaughlin, St. Thomas More College". Engaged Scholar Journal: Community-Engaged Research, Teaching, and Learning 3, n. 1 (18 ottobre 2017): 129–35. http://dx.doi.org/10.15402/esj.v1i1.230.

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In the Exchanges, we present conversations with scholars and practitioners of community engagement, responses to previously published material, and other reflections on various aspects of community-engaged scholarship meant to provoke further dialogue and discussion. In this issue, Natalia Khanenko-Friesen talks with Darrell McLaughlin of St. Thomas More College at the University of Saskatchewan. Darrell McLaughlin (PhD) is an Associate Dean at St. Thomas More College, University of Saskatchewan.

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RATTNER, SUSAN. "Jefferson Medical College of Thomas Jefferson University". Academic Medicine 75, Supplement (settembre 2000): S308—S309. http://dx.doi.org/10.1097/00001888-200009001-00090.

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4

Arenson, Christine, e Susan Rattner. "Jefferson Medical College of Thomas Jefferson University". Academic Medicine 79, Supplement (luglio 2004): S61—S69. http://dx.doi.org/10.1097/00001888-200407001-00017.

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5

Rattner, Susan L., Karen M. Glaser, Christine Arenson, John Spandorfer e John Caruso. "Jefferson Medical College of Thomas Jefferson University". Academic Medicine 85 (settembre 2010): S485—S489. http://dx.doi.org/10.1097/acm.0b013e3181ea3aad.

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6

Hanna, Ralph. "The Thomas Mans, their Books, and Jesus College Librarianship". Library 21, n. 1 (1 marzo 2020): 46–73. http://dx.doi.org/10.1093/library/21.1.46.

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Abstract On 21 January 1684/5, Thomas Man, a thirty-year-old Fellow, made a substantial donation of manuscripts to Jesus College, Cambridge. These included a substantial number of books from medieval institutional collections, including at least thirty-one from Durham cathedral priory. The essay ascertains the extent of the donation, a discussion intertwined with that of librarianship at Jesus College. It also offers information about the collection activity of Man’s father, also Thomas, who assembled the collection, and points to several Man books now preserved elsewhere.

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Heyd, Michael, e Elliott Horowitz. ""A Feather in the Wind": An Interview with Sir Keith Thomas". Journal of Early Modern History 9, n. 1 (2005): 181–92. http://dx.doi.org/10.1163/1570065054300220.

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AbstractSir Keith Thomas, fellow of All Souls College, Oxford, and former president of Corpus Christi College and The British Academy, discusses his academic background and influences, trends in early modern history, and changes in the history profession. This interview with Prof. Thomas was conducted by the Historical Society of Israel during his visit in late 2003 to deliver the Jerusalem Lectures in History in memory of Menahem Stern.

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Ziring, Deborah, Katherine Berg, Nina Mingioni, Dimitrios Papanagnou, Urvashi Vaid e Steven Herrine. "Sidney Kimmel Medical College at Thomas Jefferson University". Academic Medicine 95, n. 9S (settembre 2020): S444—S448. http://dx.doi.org/10.1097/acm.0000000000003326.

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Richardson, Carol M. "St Thomas at the English College in Rome". Journal of the British Archaeological Association 173, n. 1 (1 gennaio 2020): 183–203. http://dx.doi.org/10.1080/00681288.2020.1794346.

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Amyot, Thomas G. "Book Review: Accounting Information Systems". Review of Business Information Systems (RBIS) 2, n. 2 (1 aprile 1998): 79–81. http://dx.doi.org/10.19030/rbis.v2i2.5462.

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Tesi sul tema "Thomas College"

1

Morton, David P. "John Smyth, fellow of Christ's College, 1594-98 Baptist or Anabaptist? /". Theological Research Exchange Network (TREN), 1990. http://www.tren.com.

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DeAngelo, Christopher A. "Thomas Muffet & The College of Physicians a battle for power /". Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1578.

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3

Hirsch, Julian. "The Oberlin Near East Study Collection in Context". Oberlin College Honors Theses / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=oberlin1590254692197989.

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BENEDETTI, MARTA. "I classici attraverso l'Atlantico: la ricezione dei Padri Fondatori e Thomas Jefferson". Doctoral thesis, Università Cattolica del Sacro Cuore, 2016. http://hdl.handle.net/10280/10784.

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La tesi si occupa di verificare l’influenza che i classici greci e latini hanno esercitato su i padri fondatori americani e più in particolare su Thomas Jefferson. La prima sezione tratteggia il contesto universitario e lo studio delle lingue classiche tra seicento e settecento, comprendendo non solo le università inglesi (Oxford e Cambridge) e scozzesi, ma anche i nuovi college nati nelle colonie americane. Tale analisi dei modelli e delle pratiche educative ha permesso, in effetti, di comprendere meglio l’influenza dei classici sui rivoluzionari americani. Nello specifico viene scandagliata a fondo l’educazione ricevuta da Jefferson. Tra i numerosi spunti di studio aperti da codesto argomento, il lavoro si concentra sulle modalità con cui i classici gli furono insegnati, sul suo Commonplace Book (una raccolta di brani tratti in parte da autori antichi letti in giovinezza) e su documentazione epistolare. Quest’ultima è oggetto particolare di studio, allo scopo di scoprire quali opere antiche Jefferson, in età adulta e durante la vecchiaia, lesse e apprezzò. Essendo un collezionista di libri, comprò moltissimi testi classici come dimostrano alcuni suoi manoscritti. Nonostante manchino dati precisi a riguardo, risulta inoltre che Jefferson, benché facesse largo uso di traduzioni, preferiva leggere in originale e che probabilmente abbia letto la maggior parte di questi libri durante il ritiro dalla vita politica. La seconda parte della tesi si concentra, invece, a indagare quanto la sua educazione classica abbia contributo alla formazione della sua personalità e delle sue idee, nonché alla forma stessa del suo pensiero in merito ad alcune tematiche. Lo studio è di conseguenza dedicato all’esperienza umana di Jefferson, in particolare alla sua riflessione sulla morte e sull’eternità, temi fortemente legati alla sua ricezione di idee epicuree e stoiche. Epicureismo e Stoicismo rappresentano, in definitiva, i due sistemi filosofici antichi che hanno maggiormente influenzato la sua personalità e il suo pensiero.
The aim of the present work is to evaluate the impact of the ancient classics on the American Founding Fathers, with a particular focus on Thomas Jefferson. The first section gives a wide portrait of the academic context in which the Founders were educated, comprising not only of Oxford, Cambridge, and the Scottish universities, but also the colonial colleges. The evaluation of the educational practices in use at the time makes it possible to understand better the classical impact on revolutionary Americans. In particular, this analysis studies in depth Jefferson's education. Of the many possible perspectives and approaches to this topic, the present work focuses on the way ancient classics were taught to him, his Commonplace Book, which reports part of the ancient classics he read during his youth, and his correspondence. The latter has been studied especially to understand which other ancient writers he read, valued, and esteemed in his adulthood and old age. As book collector, Jefferson bought an incredible number of ancient classics, as attested by a few manuscripts of his book lists. Despite the dearth of sure evidence, it is very likely that he read the ancient works largely during his retirement. He loved reading them in the original, though he made great use of translations. The second part of this work is dedicated to investigating how Jefferson's classical education contributed to the building of his personality and ideas, as well as how he elaborated specific classical themes in his own life. The study is thus focused on Jefferson's personal human experience, specifically on his reflection on human mortality and the afterlife. These themes, indeed, are strictly linked to his reception of Epicurean and Stoic tenets, the two ancient philosophical systems which had the greatest and most profound impact on Jefferson's personality and thought.

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Crown, Jessica. "Renaissance humanism in England, c.1490-c.1530". Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/283230.

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This dissertation explores humanism, the rediscovery of the culture of ancient Greece and Rome, in late fifteenth- and early sixteenth-century England. It does so with reference to texts, institutional settings, and networks both within and beyond England, and examines the activities of several seemingly minor figures who have been absent from recent scholarship on the topic: John Holt, William Lily, Richard Croke, Leonard Cox, and Thomas Lupset. These figures made distinctive and original contributions to the genres in which they operated, whether the grammatical manual, educational treatise, dialogue, or philosophical meditation. They are also noteworthy for their considerable influence, whether in England or further abroad. With regard to Croke and Cox, the integration of previously unknown sources from France and Germany and overlooked ones from eastern Europe reveals that England could be an exporter and not merely an importer of humanism. Taken together, these individuals demonstrate that English humanism was more sophisticated and complex than its frequent characterisation as 'Erasmian' would suggest. In addition, this dissertation analyses the influence of humanism on two school foundations: St Paul's School and Ipswich College. It re-evaluates the portrayal of John Colet as an anti-intellectual, and understands St Paul's as a deeply personal endeavour, reflecting his desire to do better for the next generation. It establishes the depth and significance of humanism in Cardinal Wolsey's foundation of Ipswich College, hitherto accorded less importance by historians than his Oxford college. The examination of the little-known materials he published on the eve of his fall in 1529, together with reports from staff on its progress, show that he regarded it as central to his ambitious vision for England and to the creation of his own reputation as a civic humanist. This research therefore revises our understanding of a neglected period, and engages with the vexed questions at the heart of the study of humanism: how contemporaries dealt with the tension between their faith and their enthusiasm for pagan culture, and regarded the rival attractions of scholarly leisure and active public service.

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Merriman, Carolyn. "Thorax and Lungs". Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/8532.

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Carr, Harriet Christian. "Sweet Briar, 1800-1900: Palladian Plantation House, Italianate Villa, Aesthetic Retreat". VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/91.

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Sweet Briar House is one of the best documented sites in Virginia, with sources ranging from architectural drawings and extensive archives to original furnishings. Sweet Briar House was purchased by Elijah Fletcher, a prominent figure in Lynchburg, Virginia, in 1830. Thirty years later it passed into the possession of his daughter Indiana Fletcher Williams, and remained her home until her death in 1900. In her will, Williams left instructions for the founding of Sweet Briar Institute, an educational institution for women that exists today as Sweet Briar College. This dissertation examines Sweet Briar House in three distinct phases, while advancing three theses. The first thesis proposes that the double portico motif introduced by Palladio at the Villa Cornaro in the sixteenth century became the fundamental motif of Palladianism in Virginia architecture, generating a line of offspring that proliferated in the eighteenth century and beyond. The Palladian plantation (Sweet Briar House I, c. 1800) featured this double portico. In 1851, following the return of the Fletcher children from an extended Grand Tour of Europe, the house was remodeled as an Italianate villa (Sweet Briar House II, 1851-52). The second thesis advances the contention that by renovating their Palladian house into an asymmetrical Italianate villa, the Fletcher family implemented an ideal solution between the balanced façade that characterized the Palladian Sweet Briar House I and the fashion for the Picturesque that dominated American building in the second half of the nineteenth century. In 1876, the Williams family traveled to the Centennial Exhibition in Philadelphia, where visitors were presented with an unimaginable array of artistic possibilities from countless eras and nations, exactly the conditions that the Aesthetic Movement needed to flourish in America. The third thesis maintains that the Williams family’s decision to transform Sweet Briar House into an Aesthetic Movement retreat was inspired by their reaction to the Centennial, and in particular by their appreciation for the Japanese objects presented there.

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Swami, Kara. "Destabilizing the Sign:The Collage Work of Ellen Gallagher, Wangechi Mutu, and Mickalene Thomas". University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1367942466.

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Lange, Stuart, e n/a. "A rising tide : the growth of Evangelicalism and Evangelical identity among Presbyterians, Anglicans and University students in New Zealand, 1930-1965". University of Otago. Department of Theology and Religious Studies, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090618.161648.

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This thesis relates the resurgent evangelical Protestantism of mid-twentieth century New Zealand to the extensive international historiography which has emerged over the last thirty years, especially through the work of such scholars as David Bebbington in Britain and others in the USA, Canada and Australia. Understanding evangelicalism as a both an historical movement and a recurring set of doctrinal commitments, the new literature has highlighted evangelicalism as a trans-denominational and international movement, sharing such features as those identified in Bebbington�s quadrilateral. Weaving together the study of numerous key individuals, churches and organisations, the thesis argues that a self-aware, cross-denominational and fairly cohesive evangelical stream developed within New Zealand Protestantism between about 1930 and 1965. The thesis demonstrates that the university Evangelical Unions and the Inter-Varsity Fellowship (NZ) - both founded following a schism with the more liberal SCM in the early 1930s - were key factors in the reconstruction of evangelical identity and confidence and in the development of vigorous and expanding evangelical movements in New Zealand�s two largest Protestant denominations. The two key pre-war church leaders who inspired those movements, Thomas Miller (a confessionalist Presbyterian) and William Orange (a devotional Anglican), worked closely with the Evangelical Unions and IVF, and the leaders of the post-war evangelical movements (such as Graham Miller) had been significantly shaped by the EUs and IVF. Mid-century New Zealand evangelicalism was theologically conservative, but also emphasised reason, moderation and restraint, and those values were constantly reinforced by such leaders as Dr. John Laird and Professor E.M. Blaiklock. The renascent New Zealand evangelical movement rejected extremism, anti-intellectualism and ecclesiastical separatism. It explicitly distanced itself from American fundamentalism. In its outlook and cultural style, mid-twentieth century New Zealand evangelicalism largely reflected the prevailing Britishness of New Zealand in that period, and was strongly influenced by the British IVF. By the early 1960s, evangelicalism had become an increasingly significant element within Protestantism in New Zealand. As the movement matured, it had also become less cohesive.

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Nitzsche, Hagen [Verfasser], Karsten [Akademischer Betreuer] Mäder, Thomas [Akademischer Betreuer] Groth e Michaela [Akademischer Betreuer] Schulz-Siegmund. "Development and characterization of nano-hydroxyapatite, collagen, chitosan scaffolds for bone regeneration / Hagen Nitzsche. Betreuer: Karsten Mäder ; Thomas Groth ; Michaela Schulz-Siegmund". Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2010. http://d-nb.info/1025010892/34.

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Libri sul tema "Thomas College"

1

Department of Education & Science. Thomas Estley Community College. Stanmore: Department of Education and Science, 1990.

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Mielech, Ronald A. Northern Kentucky's first college: Villa Madonna-Thomas More College. Charleston, SC: History Press, 2010.

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Department of Education & Science. Thomas Estley Community College: A report by HMI. Stanmore: Department of Education and Science, 1990.

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4

Duane, Thomas David. Wills Eye Hospital and Thomas Jefferson Medical College. San Francisco, Calif: Foundation of the American Academy of Ophthalmology, 1989.

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Puritan protagonist: Thomas Clap, first president of Yale College. 2^a ed. [Philadelphia]: Xlibris Corporation, 2006.

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Duane, Thomas David. Thomas David Duane, MD, Wills Eye Hospital and Thomas Jefferson Medical College: An interview, 1988. San Francisco: Foundation of the American Academy of Ophthalmology, 1989.

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7

Wurtzel, David. Thomas Lyster: A Cambridge novel. New York: Avon, 1987.

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Tredway, J. Thomas. On and beyond the Mississippi: Essays honoring Thomas Tredway. Rock Island, Ill: Augustana Historical Society, 2004.

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Tredway, J. Thomas. On and beyond the Mississippi: Essays honoring Thomas Tredway. Rock Island, Ill: Augustana Historical Society, 2004.

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Connors, Joseph B. Journey toward fulfillment: A history of the College of St. Thomas. St. Paul, Minn: College of St. Thomas, 1986.

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Capitoli di libri sul tema "Thomas College"

1

Hollman, Arthur. "Early life · Family · Education · Medical School at University College Cardiff and University College London". In Sir Thomas Lewis, 1–12. London: Springer London, 1997. http://dx.doi.org/10.1007/978-1-4471-0927-3_1.

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Cole, Andrew. "Staging Advice in Oxford, New College, MS 288: On Thomas Chaundler and Thomas Bekynton". In Medieval Church Studies, 245–64. Turnhout: Brepols Publishers, 2011. http://dx.doi.org/10.1484/m.mcs-eb.4.2013.

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3

Schwartz, Robert. "The Pioneer: Thomas Arkle Clark, Dean of Deans". In Deans of Men and the Shaping of Modern College Culture, 21–45. New York: Palgrave Macmillan US, 2010. http://dx.doi.org/10.1057/9780230114647_2.

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4

Roberts, Phyllis B. "St. Thomas of Canterbury and the English College in Rome". In Textes et Etudes du Moyen Âge, 759–75. Turnhout: Brepols Publishers, 1998. http://dx.doi.org/10.1484/m.tema-eb.5.102815.

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Hollman, Arthur. "Graduates · House appointments at University College Hospital · Research on pulse and blood pressure · Meets Dr James Mackenzie in 1908 · Becomes editor of Heart". In Sir Thomas Lewis, 13–27. London: Springer London, 1997. http://dx.doi.org/10.1007/978-1-4471-0927-3_2.

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Roe, John. "Foreseeing and Foreknowing: Dante’s ‘Ugolino’ and the Eton College Ode of Thomas Gray". In Dante’s Modern Afterlife, 17–30. London: Palgrave Macmillan UK, 1998. http://dx.doi.org/10.1007/978-1-349-26975-4_2.

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"In the Library of Worcester College, Oxford". In The Works of Thomas de Quincey, 390–91. Routledge, 2020. http://dx.doi.org/10.4324/9780429349164-108.

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"15. The Masters of King's College to William Ogilvie". In The Edinburgh Edition of Thomas Reid: The Correspondence of Thomas Reid. Edinburgh University Press, 2002. http://dx.doi.org/10.1093/oseo/instance.00106404.

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"Another Digger Broadside: Keith Thomas, St John's College, Oxford". In The Intellectual Revolution of the Seventeenth Century (Routledge Revivals), 137–50. Routledge, 2012. http://dx.doi.org/10.4324/9780203145210-14.

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Hill, Thomas. "133 From Thomas Hill Trinity College, Cambridge, 12 September 1653". In Calendar of the Correspondence of Richard Baxter, Vol. 1: 1638–1660, a cura di N. H. Keeble e Geoffrey F. Nuttall, 108. Oxford University Press, 1991. http://dx.doi.org/10.1093/oseo/instance.00007815.

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Atti di convegni sul tema "Thomas College"

1

Brickner, Robert H. "Behind the Scenes: Historic Agreement to Develop U.S. Virgin Islands’ First Alternative Energy Facilities". In 18th Annual North American Waste-to-Energy Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/nawtec18-3516.

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In the summer of 2009, Governor John P. DeJongh, Jr. announced that the Virgin Islands Water and Power Authority (WAPA) had just signed two 20-year Power Purchase Agreements, and the Virgin Islands Waste Management Authority (VIWMA) had signed two 20-year Solid Waste Management Services Agreements with affiliates of Denver-based Alpine Energy Group, LLC (AEG) to build, own, and operate two alternative energy facilities that will serve the residents of St. Croix, St. John, and St. Thomas. The alternative energy facilities, to be built on St. Croix and St. Thomas, have a projected cost of $440 million and will convert an estimated 146,000 tons per year of municipal solid waste into refuse-derived fuel (RDF) using WastAway Services® technology, which will be combined with petroleum coke as fuel in fluidized bed combustion facilities to generate steam and electric power. These sustainable projects will provide 33 MW of electric power to St. Thomas and St. John and 16 MW of electric power to St. Croix, and will help to provide long-term cost stability for electric power and solid waste management in the Territory. Construction is expected to start in spring 2010 with an anticipated completion date during the fourth quarter of 2012. This procurement is a significant achievement for the U.S. Virgin Islands. When the projects are fully implemented, they will allow the Territory to reduce its dependence on oil, recover the energy value and certain recyclable materials from its municipal solid waste, and divert this waste from landfill. Since VIWMA has the responsibility to collect and/or dispose of solid waste year-round, having a system incorporating multiple solid waste processing lines and an adequate supply of spare parts on hand at all times is crucial to meeting the daily demands of waste receiving and processing, and RDF production. Also, with the location of the US Virgin Islands in a hurricane zone, and with only one or two combustion units available in each Project, the ability to both stockpile waste pre-RDF processing and store the produced RDF is very important. Gershman, Brickner & Bratton, Inc. (GBB)’s work has included a due diligence review of the Projects and providing professional support in VIWMA’s negotiations with AEG. GBB’s initial primary assignment centered on reviewing the design and operations of the RDF processing systems that will be built and operated under the respective Service Contracts. VIWMA needed to undertake a detailed technical review of the proposed RDF processing system, since this was the integration point of the waste collection system and waste processing/disposal services. GBB, in association with Maguire, was requested to provide this review and present the findings and opinions to VIWMA. In the completion of this effort, which included both a technical review and participation in negotiations to advance the Service Contracts for the Projects, GBB made direct contact with the key equipment suppliers for the Projects proposed by AEG. This included Bouldin Corporation, the primary RDF processing system supplier, with its patented WastAway technology, and Energy Products of Idaho, the main thermal processing equipment supplier, with its fluidized bed combustion technology and air pollution control equipment. Additionally, since the combustion systems for both Projects will generate an ash product that will require marketing for use and/or disposal over the term of the Service Contracts, GBB made contact with LA Ash, one of the potential subcontractors identified by AEG for these ash management services. Due to the nature of the contract guarantees of VIWMA to provide 73,000 tons per year of Acceptable Waste to each Project for processing, VIWMA authorized GBB to perform a current waste stream characterization study. Part of this effort included waste sorts for one week each in February 2009 on St. Croix and March 2009 on St. Thomas, with the results shared with VIWMA and AEG, as compiled. The 2009 GBB waste stream characterization study incorporated historical monthly waste weigh data from both the Bovoni and Anguilla Landfills that were received from VIWMA staff. The study has formed a basis for continuing to augment the waste quantity information from the two landfills with the additional current monthly results compiled by VIWMA staff going forward following the waste sorts. The final GBB report was published in December 2009 and includes actual USVI landfill receipt data through August 31, 2009. The information contained in this document provides the underpinnings to allow for better tracking and analysis of daily, weekly and monthly waste quantities received for recycling, processing and disposal, which are important to the overall waste processing system operations, guarantees and cost projections. GBB’s annual projections are that the total waste on St. Croix is currently over 104,000 tons per year and over 76,000 tons per year on St. Thomas. The thermal processing technology selected for both Projects is a fluidized bed process, employing a heated bed of sand material “fluidized” in a column of air to burn the fuel — RDF and/or Pet Coke. As such, the solid waste to be used in these combustion units must be size-reduced from the myriad of sizes of waste set out at the curb or discharged into the large roll-off boxes or bins at the many drop-off sites in the US Virgin Islands. While traditional RDF would typically have several days of storage life, the characteristics of the pelletized RDF should allow several weeks of storage. This will be important to having a sound and realistic operating plan, given the unique circumstances associated with the climate, waste moisture content, island location, lack of back-up disposal options and downtime associated with the Power Generation Facility. During the negotiations between AEG and VIWMA, in which GBB staff participated, in addition to RDF and pelletized RDF as the waste fuel sources, other potential fuels have been discussed for use in the Projects and are included as “Opportunity Fuels” in the Service Contracts. These Opportunity Fuels include ground woody waste, dried sludges, and shredded tires, for example. Therefore, the flexibility of the EPI fluidized bed combustion boilers to handle multi-fuels is viewed as an asset over the long term, especially for an island location where disposal options are limited and shipping materials onto and off of each island is expensive. This presentation will provide a unique behind-the-scenes review of the process that led to this historic agreement, from the due diligence of the proposed technologies, to implementation planning, to the negotiations with the contractor. Also discussed will be the waste characterization and quantity analysis performed in 2009 and the fast-track procurement planning and procurement of construction and operating services for a new transfer station to be sited on St. Croix.

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Lumley, P., E. W. Collington, P. Hallett, E. J. Hornby, p. PA Humphrey, C. J. Wallis, D. Jack e R. T. Brittain. "THE EFFECTS OF GR32191, A NEW THROMBOXANE RECEPTOR BLOCKING DRUG,ON PLATELETS AND VASCULAR SMOOTH MUSCLE IN VITRO". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643754.

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Abstract (sommario):

The effect of a new thromboxane receptor blocking drug GR32191 ([1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1"-biphenyl)-4-yl]methoxy] -3-hydroxy-2-(l-piperidinyl)cyclopentyl]-4-heptenoic acid,hydrochloride) has been examined upon platelets and vascular smooth muscle. In human platelet-rich plasma (PRP), aggregation to thromboxane(Tx) A2, PGH2, arachidonic acid, collagen andU-46619 was antagonised by GR32191 (IC50 range 2-36 nM).Primary aggregation (PRP treated with aspirin 10 pM) to ADP, 5-HT and adrenaline were unaffected by concentrations of GR32191 up to 10 pM. In human PRP, U-46619-induced aggregation and 5-HT release were antagonised by GR32191(10-100 nM). In contrast, in theabsence of aspirin, ADP-induced 5-HT release,but not aggregation, was antagonised by the compound implicating a role for TXA2 in the release process. In human PRP GR32191 (up to 30μM) did not itself induce aggregation or, in the presence of EGTA (4 mM), induce detectable shape change. Up to 10 μM GR32191 was without effect upon the inhibitory activity of PGI2 or PGD2 and at 1μMhad no significant inhibitory activity upon fatty acid cyclooxygenase, thromboxane synthase, prostacyclin synthase, 12-lipoxygenase orphosphodiesterase. The effect of GR32191was quantified further in human platelets suspended in whole blood or physiological salt solution. Aggregation to U-46619 was antagonised byGR32191 with a pA2 (slope of the Schild regression) of 8.2 (1.3) in whole blood and 8.8 (1.3) in resuspended platelets. The compound competitively and specifically antagonised the contractions of strips of human isolatedpulmonary blood vessels and rat and guinea-pig aortic strips produced by U-46619 with pA2 (slope) values of 8.2 (1.1), 7.9 (0.9) and 8.7(0.9) respectively. In contrast contractions induced by KC1 and 5-HT (rat) orKC1and histamine (guinea-pig) were unaffectedbyconcentrations of GR32191 up to 30 μM.Thus GR32191 is a potent and specific thromboxane receptor blocking drug on platelets and vascular smooth muscle in vitro. It is orally active and long lasting in man (Thomas, M et al.,this meeting).

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Rapporti di organizzazioni sul tema "Thomas College"

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Rattelman, Cori, Linda Marr e Jacquelyn Sanders. Navy/Thomas Nelson Community College MLT Training Pilot Evaluation. Fort Belvoir, VA: Defense Technical Information Center, giugno 2002. http://dx.doi.org/10.21236/ada630930.

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