Articoli di riviste: "Ultimate Cell"

1

Frantz, Simon. "The ultimate stem cell...part 1". Nature Reviews Molecular Cell Biology 3, n. 3 (marzo 2002): 148. http://dx.doi.org/10.1038/nrm752.

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Frantz, Simon. "The ultimate stem cell...part 2". Nature Reviews Molecular Cell Biology 3, n. 3 (marzo 2002): 148. http://dx.doi.org/10.1038/nrm754.

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VINEY, J. L. "Dendritic cell subsets: the ultimate T cell differentiation decision makers?" Gut 45, n. 5 (1 novembre 1999): 640–41. http://dx.doi.org/10.1136/gut.45.5.640.

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Gattinoni, Luca, Christopher A. Klebanoff e Nicholas P. Restifo. "Paths to stemness: building the ultimate antitumour T cell". Nature Reviews Cancer 12, n. 10 (21 settembre 2012): 671–84. http://dx.doi.org/10.1038/nrc3322.

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Piedrahita, J. A. "Somatic Cell Cloning: The Ultimate Form of Nuclear Reprogramming?" Journal of the American Society of Nephrology 15, n. 5 (1 maggio 2004): 1140–44. http://dx.doi.org/10.1097/01.asn.0000110183.87476.05.

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Hagios, Carmen, André Lochter e Mina J. Bissell. "Tissue architecture: the ultimate regulator of epithelial function?" Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 353, n. 1370 (29 giugno 1998): 857–70. http://dx.doi.org/10.1098/rstb.1998.0250.

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The architecture of a tissue is defined by the nature and the integrity of its cellular and extracellular compartments, and is based on proper adhesive cell–cell and cell–extracellular matrix interactions. Cadherins and integrins are major adhesion–mediators that assemble epithelial cells together laterally and attach them basally to a subepithelial basement membrane, respectively. Because cell adhesion complexes are linked to the cytoskeleton and to the cellular signalling pathways, they represent checkpoints for regulation of cell shape and gene expression and thus are instructive for cell behaviour and function. This organization allows a reciprocal flow of mechanical and biochemical information between the cell and its microenvironment, and necessitates that cells actively maintain a state of homeostasis within a given tissue context. The loss of the ability of tumour cells to establish correct adhesive interactions with their microenvironment results in disruption of tissue architecture with often fatal consequences for the host organism. This review discusses the role of cell adhesion in the maintenance of tissue structure and analyses how tissue structure regulates epithelial function.

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Co., Ltd., Asahi-Seiki Manufacturing. "LTP-45/Ultimate Transfer Press for Li-Ion Battery Cell". Journal of the Japan Society for Technology of Plasticity 53, n. 621 (2012): 915–16. http://dx.doi.org/10.9773/sosei.53.915.

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Jensen, Marc W., e Marc Ross. "The Ultimate Challenge: Developing an Infrastructure for Fuel Cell Vehicles". Environment: Science and Policy for Sustainable Development 42, n. 7 (settembre 2000): 10–22. http://dx.doi.org/10.1080/00139150009605747.

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Lee, Donghoon M., e Elizabeth H. Chen. "Drosophila Myoblast Fusion: Invasion and Resistance for the Ultimate Union". Annual Review of Genetics 53, n. 1 (3 dicembre 2019): 67–91. http://dx.doi.org/10.1146/annurev-genet-120116-024603.

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Cell–cell fusion is indispensable for creating life and building syncytial tissues and organs. Ever since the discovery of cell–cell fusion, how cells join together to form zygotes and multinucleated syncytia has remained a fundamental question in cell and developmental biology. In the past two decades, Drosophila myoblast fusion has been used as a powerful genetic model to unravel mechanisms underlying cell–cell fusion in vivo. Many evolutionarily conserved fusion-promoting factors have been identified and so has a surprising and conserved cellular mechanism. In this review, we revisit key findings in Drosophila myoblast fusion and highlight the critical roles of cellular invasion and resistance in driving cell membrane fusion.

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Bissell, Mina J., Aylin Rizki e I. Saira Mian. "Tissue architecture: the ultimate regulator of breast epithelial function". Current Opinion in Cell Biology 15, n. 6 (dicembre 2003): 753–62. http://dx.doi.org/10.1016/j.ceb.2003.10.016.

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Talluri, V. S. S. L. Prasad, M. Bhavana, M. V. S. Mahesh Kumar e S. V. Rajagopal. "L-Asparaginase: An Ultimate Anti-Neoplastic Enzyme". International Letters of Natural Sciences 15 (maggio 2014): 23–35. http://dx.doi.org/10.18052/www.scipress.com/ilns.15.23.

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The objective of the study described the importance of L-asparaginase and its importance in the field of medicine. Different types of enzymes are produced based on the adaptation to the environment where the living organisms live to tune the metabolic pathways according to their adapted changes. The enzymes present in various organs are produced by many cell types in multicellular organisms. Except ribosomes all other known enzymes are proteinaceous in nature. L-asparaginase is a potential therapeutic agent for acute lymphoblastic leukemia (ALL) and chronic myelogenous leukemia which is approved by FDA & WHO. L-asparaginase catalyzes the deamination of L-asparagine to L-aspartic acid & ammonia. Unlike normal cells, malignant cells require large amount of L-asparagine for protein synthesis and cell division. From this background the present review is an effort to gather the information on the mechanism, sources, molecular details and application of L-asparaginase enzyme.

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Woods, Amina S. "The dopamine D4receptor, the ultimate disordered protein". Journal of Receptors and Signal Transduction 30, n. 5 (14 settembre 2010): 331–36. http://dx.doi.org/10.3109/10799893.2010.513842.

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Padron Velazquez, Julio Lazaro. "Stem cell fusion as an ultimate line of defense against xenobiotics". Medical Hypotheses 67, n. 2 (gennaio 2006): 383–87. http://dx.doi.org/10.1016/j.mehy.2006.01.031.

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James A. McCubrey, Linda S. Steelman, Stephen L. Abrams, Negin Misaghian, William H. Chappell, Sanja Mijatovic, Giuseppeo Montalto et al. "Targeting the Cancer Initiating Cell: The Ultimate Target for Cancer Therapy". Current Pharmaceutical Design 18, n. 13 (23 aprile 2012): 1784–95. http://dx.doi.org/10.2174/138161212799859701.

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Serykh, V. P. "Ultimate volume of a unit cell determined by powder diffraction methods". Crystallography Reports 51, n. 3 (maggio 2006): 541. http://dx.doi.org/10.1134/s1063774506030333.

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Serykh, V. P. "Ultimate volume of a unit cell determined by powder diffraction methods". Crystallography Reports 50, n. 4 (luglio 2005): 537–38. http://dx.doi.org/10.1134/1.1996726.

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Sadoway, Donald R. "Inert anodes for the Hall-Héroult cell: The ultimate materials challenge". JOM 53, n. 5 (maggio 2001): 34–35. http://dx.doi.org/10.1007/s11837-001-0206-5.

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Goswami, Arjyajyoti, S. Aravindan e PV Rao. "Optimization of nanohole array parameters for improving the ultimate efficiency of nanohole structured c-Si solar cells". Proceedings of the Institution of Mechanical Engineers, Part N: Journal of Nanomaterials, Nanoengineering and Nanosystems 230, n. 4 (3 agosto 2016): 231–40. http://dx.doi.org/10.1177/1740349915586622.

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Abstract (sommario):

Surface texturing helps in reducing the reflectance of the surface and hence it improves the ultimate efficiency of the solar cell. In this article, rigorous coupled wave analysis was used to find out the effect of different nanohole parameters such as nanohole diameter (D), pitch (P) and nanohole depth (H) on the reflectance and the ultimate efficiency of a c-Si solar cell of 275 μm thickness. Response surface methodology was used for co-relating the nanohole geometry parameters with the ultimate efficiency. The developed relation was used for optimization using genetic algorithm implemented through MATLAB. The optimized parameters have resulted in a 17.81% improvement in ultimate efficiency as compared with bare substrate of same thickness. A comparative study was made on the effect of parameters on the ultimate efficiency of the solar cell and it was found that higher value of diameter yielded greater ultimate efficiency. Finally, the performance of structured Si was compared with that of bare Si and Si coated with anti-reflective coating in various configurations. A 50 nm deep hole filled with anti-reflective coating and with a top surface anti-reflective coating of 75 nm yielded the highest ultimate efficiency of 47.61%.

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Werner, Michael T., Chen Zhao, Qian Zhang e Mariusz A. Wasik. "Nucleophosmin-anaplastic lymphoma kinase: the ultimate oncogene and therapeutic target". Blood 129, n. 7 (16 febbraio 2017): 823–31. http://dx.doi.org/10.1182/blood-2016-05-717793.

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Abstract Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase physiologically expressed by fetal neural cells. However, aberrantly expressed ALK is involved in the pathogenesis of diverse malignancies, including distinct types of lymphoma, lung carcinoma, and neuroblastoma. The aberrant ALK expression in nonneural cells results from chromosomal translocations that create novel fusion proteins. These protein hybrids compose the proximal part of a partner gene, including its promoter region, and the distal part of ALK, including the coding sequence for the entire kinase domain. ALK was first identified in a subset of T-cell lymphomas with anaplastic large cell lymphoma (ALCL) morphology (ALK+ ALCL), the vast majority of which harbor the well-characterized nucleophosmin (NPM)-ALK fusion protein. NPM-ALK co-opts several intracellular signal transduction pathways, foremost being the STAT3 pathway, normally activated by cytokines from the interleukin-2 (IL-2) family to promote cell proliferation and to inhibit apoptosis. Many genes and proteins modulated by NPM-ALK are also involved in evasion of antitumor immune response, protection from hypoxia, angiogenesis, DNA repair, cell migration and invasiveness, and cell metabolism. In addition, NPM-ALK uses epigenetic silencing mechanisms to downregulate tumor suppressor genes to maintain its own expression. Importantly, NPM-ALK is capable of transforming primary human CD4+ T cells into immortalized cell lines indistinguishable from patient-derived ALK+ ALCL. Preliminary clinical studies indicate that inhibition of NPM-ALK induces long-lasting complete remissions in a large subset of heavily pretreated adult patients and the vast majority of children with high-stage ALK+ ALCL. Combining ALK inhibition with other novel therapeutic modalities should prove even more effective.

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Malarkey, Christopher S., e Mair E. A. Churchill. "The high mobility group box: the ultimate utility player of a cell". Trends in Biochemical Sciences 37, n. 12 (dicembre 2012): 553–62. http://dx.doi.org/10.1016/j.tibs.2012.09.003.

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21

Sassin, M. B., Y. Garsany, B. D. Gould e K. Swider-Lyons. "Impact of Cell Compression on Resistance, Mass Transport, and Ultimate PEMFC Performance". ECS Transactions 69, n. 17 (2 ottobre 2015): 1303–11. http://dx.doi.org/10.1149/06917.1303ecst.

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Das, Payel, Saradindu Saha e Somdeb BoseDasgupta. "The ultimate fate determinants of drug induced cell-death mechanisms in Trypanosomatids". International Journal for Parasitology: Drugs and Drug Resistance 15 (aprile 2021): 81–91. http://dx.doi.org/10.1016/j.ijpddr.2021.01.003.

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23

Urist, Marshall R. "Stimulating Associates: The Ultimate Resource in Research". Connective Tissue Research 23, n. 2-3 (gennaio 1989): 107–13. http://dx.doi.org/10.3109/03008208909002410.

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24

Romero Vielva, Laura. "Tumor lymphocytic infiltration in non-small cell lung cancer: the ultimate prognostic marker?" Translational Lung Cancer Research 5, n. 4 (agosto 2016): 370–72. http://dx.doi.org/10.21037/tlcr.2016.07.07.

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25

Narumiya, Shuh, e Masanori Fukushima. "Δ12-prostaglandin J2, an ultimate metabolite of prostaglandin D2 exerting cell growth inhibition". Biochemical and Biophysical Research Communications 127, n. 3 (marzo 1985): 739–45. http://dx.doi.org/10.1016/s0006-291x(85)80005-x.

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Kłos, Jarosław W., e Maciej Krawczyk. "Two-dimensional GaAs/AlGaAs superlattice structures for solar cell applications: Ultimate efficiency estimation". Journal of Applied Physics 106, n. 9 (novembre 2009): 093703. http://dx.doi.org/10.1063/1.3253584.

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27

Velcheti, Vamsidhar, David Schrump e Yogen Saunthararajah. "Ultimate Precision: Targeting Cancer but Not Normal Self-replication". American Society of Clinical Oncology Educational Book, n. 38 (maggio 2018): 950–63. http://dx.doi.org/10.1200/edbk_199753.

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Abstract (sommario):

Self-replication is the engine that drives all biologic evolution, including neoplastic evolution. A key oncotherapy challenge is to target this, the heart of malignancy, while sparing the normal self-replication mandatory for health and life. Self-replication can be demystified: it is activation of replication, the most ancient of cell programs, uncoupled from activation of lineage-differentiation, metazoan programs more recent in origin. The uncoupling can be physiologic, as in normal tissue stem cells, or pathologic, as in cancer. Neoplastic evolution selects to disengage replication from forward-differentiation where intrinsic replication rates are the highest, in committed progenitors that have division times measured in hours versus weeks for tissue stem cells, via partial loss of function in master transcription factors that activate terminal-differentiation programs (e.g., GATA4) or in the coactivators they use for this purpose (e.g., ARID1A). These loss-of-function mutations bias master transcription factor circuits, which normally regulate corepressor versus coactivator recruitment, toward corepressors (e.g., DNMT1) that repress rather than activate terminal-differentiation genes. Pharmacologic inhibition of the corepressors rebalances to coactivator function, activating lineage-differentiation genes that dominantly antagonize MYC (the master transcription factor coordinator of replication) to terminate malignant self-replication. Physiologic self-replication continues, because the master transcription factors in tissue stem cells activate stem cell, not terminal-differentiation, programs. Druggable corepressor proteins are thus the barriers between self-replicating cancer cells and the terminal-differentiation fates intended by their master transcription factor content. This final common pathway to oncogenic self-replication, being separate and distinct from the normal, offers the favorable therapeutic indices needed for clinical progress.

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Savage, Kerry J. "Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas". Hematology 2008, n. 1 (1 gennaio 2008): 280–88. http://dx.doi.org/10.1182/asheducation-2008.1.280.

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AbstractPeripheral NK/T-cell neoplasms are an uncommon group of diseases that show distinct racial and geographic variation. The prognostic significance of the T-cell phenotype has been clearly defined in recent studies by using modern lymphoma classification systems. However, within this heterogenous group of neoplasms, some have a more favorable prognosis, such as ALK-positive anaplastic large-cell leukemia (ALCL) and primary cutaneous ALCL, and some have ultimately fatal courses with standard chemotherapy programs (e.g., hepatosplenic γδ T-cell lymphomas). Further, unlike the benefits observed with CHOP chemotherapy in the treatment of diffuse large B-cell lymphoma (DLBCL), peripheral T-cell lymphomas (PTCL), other than ALK-positive ALCL, are relatively chemoresistant to this regimen. Given disease rarity and biological heterogeneity, advances in diagnosis, prognosis and treatment have lagged behind DLBCL. Recently, however, studies are emerging that focus specifically on PTCLs with the ultimate goal of better understanding disease biology and developing more effective therapies.

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Pham, Phuc H., Jun-Wen Li, Dustin Ammendolia, Patrick G. Pumputis, Lucy E. J. Lee e Niels C. Bols. "Prolonged survival but ultimate cell death of the rainbow trout macrophage cell line, RTS11, under different starvation regimens". Fish & Shellfish Immunology 53 (giugno 2016): 118. http://dx.doi.org/10.1016/j.fsi.2016.04.104.

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Extermann, Martine. "Geriatric oncology: The ultimate personalized cancer care". Journal of Clinical Oncology 27, n. 15_suppl (20 maggio 2009): s2a. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.s2a.

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s2a In many aspects, geriatric oncology is the quintessential expression of ASCO's 2009 theme: personalizing cancer care (PCC). PCC has two aspects: the tumor and the patient. Major efforts are conducted to identify mechanisms in an individual tumor that could be targeted more effectively by therapies. This research generates huge amounts of data, which creates a challenge in selecting the best therapeutic targets. As senescence has aspects that both prevent and favor cancer, we could take advantage of basic aging research to identify more effectively which mechanisms are key, and which are epiphenomena. Increasingly recognized also is the role of the microenvironment and macroenvironment—the patient—in influencing cancer prognosis and treatment tolerance. Here again, we can learn much from older patients. Seventy-five-year-olds are much more diverse than 25-year-olds. This provides higher sensitivity to detect patient-related factors. The last decade of work in geriatric oncology has demonstrated that geriatric instruments improve prognostic assessment beyond classic oncology predictors. Tantalizing data show that a geriatric intervention might even improve significantly the survival of patients with cancer. We now have screening tools simple enough to be used in oncology practice. In the same way that we are moving away from, for example, lumping all non-small cell lung cancers together, we are moving away from considering the patient condition as a relatively neutral background summarized by an ECOG Performance Status. Older patients also have remarkably diverse life experiences and patterns of functioning. This has enabled significant learning about individualizing the prediction of treatment tolerance and of willingness to undertake it. Geriatric oncology is an ideal terrain to explore end points such as the maintenance of independence and personal goals by cancer survivors. As the world population ages, we are progressing toward providing cancer care tailored to both the tumor and the older cancer patient.

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Zhang, Jun Xia, e Sheng Zhong. "WCDMA Wireless Resource Utilization Analysis Based on Ultimate Bearing Capacity". Advanced Materials Research 971-973 (giugno 2014): 1858–61. http://dx.doi.org/10.4028/www.scientific.net/amr.971-973.1858.

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Wireless resource utilization has been the focus of WCDMA research in the past, but due to the independence between the various resources in the process of load monitoring and analysis, wireless resource utilization is difficult in the holistic assessment and lack of the analysis of the ultimate bearing capacity. In this paper, two kinds of wireless resource utilization algorithm are discussed, and the method of determining efficient cell is given through a joint analysis of two algorithms.

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Schatten, Heide. "Introduction to Stem Cell Special Section". Microscopy and Microanalysis 17, n. 4 (11 luglio 2011): 473. http://dx.doi.org/10.1017/s1431927611011998.

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The prospect of utilizing stem cells for clinical applications has generated an enormous amount of enthusiasm in the stem cell research community and has led to a wealth of new data that offer the possibility for practical applications into clinical translation. Recent advances in stem cell imaging has contributed greatly to the ultimate goal to identify and culture specific cell types for regeneration of tissue that had been affected by disease such as Parkinson's, Alzheimer's, heart disease, muscle diseases, and others.

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Schmidt, Laura E., Enrico Calzavarini, Detlef Lohse, Federico Toschi e Roberto Verzicco. "Axially homogeneous Rayleigh–Bénard convection in a cylindrical cell". Journal of Fluid Mechanics 691 (1 dicembre 2011): 52–68. http://dx.doi.org/10.1017/jfm.2011.440.

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AbstractPrevious numerical studies have shown that the ‘ultimate regime of thermal convection’ can be attained in a Rayleigh–Bénard cell when the kinetic and thermal boundary layers are eliminated by replacing both lateral and horizontal walls with periodic boundary conditions (homogeneous Rayleigh–Bénard convection). Then, the heat transfer scales like $\mathit{Nu}\ensuremath{\sim} {\mathit{Ra}}^{1/ 2} $ and turbulence intensity as $\mathit{Re}\ensuremath{\sim} {\mathit{Ra}}^{1/ 2} $, where the Rayleigh number $\mathit{Ra}$ indicates the strength of the driving force (for fixed values of $\mathit{Pr}$, which is the ratio between kinematic viscosity and thermal diffusivity). However, experiments never operate in unbounded domains and it is important to understand how confinement might alter the approach to this ultimate regime. Here we consider homogeneous Rayleigh–Bénard convection in a laterally confined geometry – a small-aspect-ratio vertical cylindrical cell – and show evidence of the ultimate regime as $\mathit{Ra}$ is increased: in spite of the lateral confinement and the resulting kinetic boundary layers, we still find $\mathit{Nu}\ensuremath{\sim} \mathit{Re}\ensuremath{\sim} {\mathit{Ra}}^{1/ 2} $ at $\mathit{Pr}= 1$. Further, it is shown that the system supports solutions composed of modes of exponentially growing vertical velocity and temperature fields, with $\mathit{Ra}$ as the critical parameter determining the properties of these modes. Counter-intuitively, in the low-$\mathit{Ra}$ regime, or for very narrow cylinders, the numerical simulations are susceptible to these solutions, which can dominate the dynamics and lead to very high and unsteady heat transfer. As $\mathit{Ra}$ is increased, interaction between modes stabilizes the system, evidenced by the increasing homogeneity and reduced fluctuations in the root-mean-square velocity and temperature fields. We also test that physical results become independent of the periodicity length of the cylinder, a purely numerical parameter, as the aspect ratio is increased.

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Cole, David K. "The ultimate mix and match: making sense of HLA alleles and peptide repertoires". Immunology & Cell Biology 93, n. 6 (31 marzo 2015): 515–16. http://dx.doi.org/10.1038/icb.2015.40.

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Godovsky, Dmitry. "Modeling the ultimate efficiency of polymer solar cell using Marcus theory of electron transfer". Organic Electronics 12, n. 1 (gennaio 2011): 190–94. http://dx.doi.org/10.1016/j.orgel.2010.10.015.

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DUCKETT, JEFFREY G., e KAREN S. RENZAGLIA. "Cell and molecular biology of bryophytes: ultimate limits to the resolution of phylogenetic problems". Botanical Journal of the Linnean Society 98, n. 3 (novembre 1988): 225–46. http://dx.doi.org/10.1111/j.1095-8339.1988.tb02426.x.

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Santoro, Carlo, Francesca Soavi, Alexey Serov, Catia Arbizzani e Plamen Atanassov. "Self-powered supercapacitive microbial fuel cell: The ultimate way of boosting and harvesting power". Biosensors and Bioelectronics 78 (aprile 2016): 229–35. http://dx.doi.org/10.1016/j.bios.2015.11.026.

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Grever, Michael R., e Gerard Lozanski. "Modern Strategies for Hairy Cell Leukemia". Journal of Clinical Oncology 29, n. 5 (10 febbraio 2011): 583–90. http://dx.doi.org/10.1200/jco.2010.31.7016.

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Abstract (sommario):

Enormous progress in the treatment of hairy cell leukemia over the last five decades has emerged as a result of organized clinical investigations. Although interferon represented one of the initial major therapeutic advances in the management of this disease in 1984, the subsequent introduction of purine nucleoside analogs (pentostatin and cladribine) changed the natural history of this rare disease by achieving a high rate of complete and durable remissions. The disease-free survival after effective therapy has not reached a plateau, suggesting control but not cure of the disease. Identification of minimal residual disease in patients achieving a complete hematologic remission provides insight into the potential source for predicting eventual relapse. Modern strategies of targeted therapies directed against immunophenotypic markers on the leukemic cells provide hope that improved long-term control of the disease is possible. Combined chemoimmunotherapy may hold the highest promise for disease eradication, but the optimal strategy for using this approach is under active investigation. Despite the perception by hematologists that this disease has already been conquered, there are critically important unanswered questions that remain. Investigation of the bone marrow microenvironment and its impact on minimal residual disease may ultimately prevent relapse. Consideration of the median age of patients at diagnosis combined with a substantial relapse rate mandates continued pursuit of improved therapy. The ultimate goal will be to achieve cure rather than simple control of the disease.

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Miller, Connie. "Who's Calling? Cell-Phone Sociometry". Journal of Psychodrama, Sociometry, and Group Psychotherapy 61, n. 1 (1 aprile 2013): 73–75. http://dx.doi.org/10.12926/0731-1273-61.1.73.

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Sociometrists seek ways to enliven interactive processes, which make the spontaneity state more accessible while addressing norms and structures that inhibit and distance people from one another. A high value is placed on integration, coherence, empathic processes, authenticity, and creative solving of shared concerns. The ultimate purpose is transcendence. However, as the director, how can that happen if my own ego is in the way? What happens if I focus outside of myself and become annoyed at and do not surrender myself to the group process? The challenge becomes one of, “How do I let go of control as a group leader? How do I increase my own trust in the group process?”

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Tauchi, H., e S. Sawada. "Analysis of Mitotic Cell Death Caused by Radiation in Mouse Leukaemia L5178Y Cells: Apoptosis is the Ultimate Form of Cell Death Following Mitotic Failure". International Journal of Radiation Biology 65, n. 4 (gennaio 1994): 449–55. http://dx.doi.org/10.1080/09553009414550521.

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Lallemand-Breitenbach, Valérie, e Hugues de Thé. "Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia?" Blood 122, n. 12 (19 settembre 2013): 2008–10. http://dx.doi.org/10.1182/blood-2013-06-505115.

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Abstract Rarely in the field of cancer treatment did we experience as many surprises as with acute promyelocytic leukemia (APL). Yet, the latest clinical trial reported by Lo-Coco et al in the New England Journal of Medicine is a practice-changing study, as it reports a very favorable outcome of virtually all enrolled low-intermediate risk patients with APL without any DNA-damaging chemotherapy. Although predicted from previous small pilot studies, these elegant and stringently controlled results open a new era in leukemia therapy.

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Starkov, Konstantin E. "A Cancer Model for the Angiogenic Switch and Immunotherapy: Tumor Eradication in Analysis of Ultimate Dynamics". International Journal of Bifurcation and Chaos 30, n. 10 (agosto 2020): 2050150. http://dx.doi.org/10.1142/s0218127420501503.

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In this paper, we study ultimate dynamics and derive tumor eradication conditions for the angiogenic switch model developed by Viger et al. This model describes the behavior and interactions between host ([Formula: see text]); effector ([Formula: see text]); tumor ([Formula: see text]); endothelial ([Formula: see text]) cell populations. Our approach is based on using the localization method of compact invariant sets and the LaSalle theorem. The ultimate upper bound for each cell population and ultimate lower bound for the effector cell population are found. These bounds describe a location of all bounded dynamics. We construct the domain bounded in [Formula: see text]- and [Formula: see text]-variables which contains the attracting set of the system. Further, we derive conditions imposed on the model parameters for the location of omega-limit sets in the plane [Formula: see text] (the case of a localized tumor). Next, we present conditions imposed on the model and treatment parameters for the location of omega-limit sets in the plane [Formula: see text] (the case of global tumor eradication). Various types of dynamics including the chaotic attractor and convergence dynamics are described. Numerical simulation illustrating tumor eradication theorems is fulfilled as well.

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Zhang, Chuan-Wei, Fang-Yi Li, Jian-Feng Li, Hai-Yang Lu e Geng Wang. "Bubble Wall Rupture Model for Open Cell Structure in Starch/Fiber Heterogeneous Composites". Journal of Biobased Materials and Bioenergy 14, n. 2 (1 aprile 2020): 169–77. http://dx.doi.org/10.1166/jbmb.2020.1955.

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Starch/fiber heterogeneous composites were prepared through thermos-cavity foaming machine. Open cell structures are widely distributed in the heterogeneous composites. Bubble wall rupture is an inevitable stage in the formation of open cells. Different from the conventional models to explain the bubble wall rupture from the energy and the wave point of view, this study suggests the "local thinning ultimate stress" model to reveal the bubble wall rupture from the stress perspective. The local stress of the starch bubble wall is increased with the thinning of the bubble wall. The bubble wall ruptures when local stress exceeds the ultimate surface tension. Starch slurry retraction occurs after bubble wall rupturing. The elastic retraction drives partially open cells to fully open cell morphologies in the starch/fiber heterogeneous composite. The developed mechanism was validated by starch/fiber slurry with different viscosities to design a novel biodegradable composite with fully open cell structures.

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Goenka, Radhika, Lisa G. Barnett, Jonathan S. Silver, Patrick J. O’Neill, Christopher A. Hunter, Michael P. Cancro e Terri M. Laufer. "Cutting Edge: Dendritic Cell-Restricted Antigen Presentation Initiates the Follicular Helper T Cell Program but Cannot Complete Ultimate Effector Differentiation". Journal of Immunology 187, n. 3 (29 giugno 2011): 1091–95. http://dx.doi.org/10.4049/jimmunol.1100853.

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45

Scelza, Miriam Zaccaro, Isleine Portal Caldas, Jhony Medeiros de Mattos, Felipe Oliveira, Waldimir Carvalho e Gutemberg Gomes Alves. "In Vitro Analysis of the Cytotoxicity of Indirect Restorative Materials". Brazilian Dental Journal 29, n. 5 (settembre 2018): 507–12. http://dx.doi.org/10.1590/0103-6440201801919.

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Abstract This study aimed to compare the cytotoxicity of the Vita AC12, Lava Ultimate, Vita Enamic and InSync indirect restorative materials. Extracts of each material were prepared by incubation for 1, 7 and 40 days, with daily washing. Human gingival fibroblasts were exposed to the extracts, and cell viability was evaluated by sequential assessment of mitochondrial activity (XTT), membrane integrity (NRU) and cell density (CVDE). Extracts of polystyrene beads and latex fragments were used as negative and positive controls, respectively. Differences between groups and experimental times were evaluated by analysis of variance. At the 24 h extraction, significant differences between the control and both Vita AC-12 and InSync were observed in the XTT assay (p<0.05), and between the control and both Enamic and Lava Ultimate, in the CVDE assay (p<0.05). AC12, Lava Ultimate, and InSync presented significantly lower cell viability than Enamic and the control group, in the NRU assay (p<0.05). The Vita Enamic and Lava Ultimate hybrid ceramic-like materials presented better biocompatibility at the 24 h extraction time point than the AC12 and InSync ceramic materials. However, a simulation of the removal of toxic components by biological fluids, conducted by using longer extraction times and daily washing, led to the absence of cytotoxicity in all the tested restorative materials. These findings can be viewed as positive for the clinical indication of these restorative materials, considering their contact with adjacent soft tissues for extended periods of time.

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46

Nyström, T. "To be or not to be: the ultimate decision of the growth-arrested bacterial cell". FEMS Microbiology Reviews 21, n. 4 (febbraio 1998): 283–90. http://dx.doi.org/10.1016/s0168-6445(97)00060-0.

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Nyström, Thomas. "To be or not to be: the ultimate decision of the growth-arrested bacterial cell". FEMS Microbiology Reviews 21, n. 4 (febbraio 1998): 283–90. http://dx.doi.org/10.1111/j.1574-6976.1998.tb00354.x.

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48

Yano, Kazuyuki, Masaru Sonoda, Yoshikatsu Sakagishi, Yasushi Sakamoto e Keiichi Uycmura. "Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens". Carcinogenesis 9, n. 6 (1988): 1085–90. http://dx.doi.org/10.1093/carcin/9.6.1085.

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Wang, Zihao, e Zhenzhou Wang. "A generic approach for cell segmentation based on Gabor filtering and area-constrained ultimate erosion". Artificial Intelligence in Medicine 107 (luglio 2020): 101929. http://dx.doi.org/10.1016/j.artmed.2020.101929.

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50

Kim, In Gul, Hana Cho, Jisoo Shin, Jung Ho Cho, Seung-Woo Cho e Eun-Jae Chung. "Regeneration of irradiation-damaged esophagus by local delivery of mesenchymal stem-cell spheroids encapsulated in a hyaluronic-acid-based hydrogel". Biomaterials Science 9, n. 6 (2021): 2197–208. http://dx.doi.org/10.1039/d0bm01655a.

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