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Articoli di riviste sul tema "Ying han dui zhao"

Autore: Grafiati

Pubblicato: 12 dicembre 2022

Ultima modifica: 31 luglio 2025

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1

Lyu, Zhi-Tong, Yang Chen, Jian-Huan Yang, et al. "A new species of Nidirana from the N. pleuraden group (Anura, Ranidae) from western Yunnan, China." Zootaxa 4861, no. 1 (2020): 43–62. https://doi.org/10.11646/zootaxa.4861.1.3.

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Lyu, Zhi-Tong, Chen, Yang, Yang, Jian-Huan, Zeng, Zhao-Chi, Wang, Jian, Zhao, Jian, Wan, Han, Pang, Hong, Wang, Ying-Yong (2020): A new species of Nidirana from the N. pleuraden group (Anura, Ranidae) from western Yunnan, China. Zootaxa 4861 (1): 43-62, DOI: 10.11646/zootaxa.4861.1.3

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Lyu, Zhi-Tong, Zhao-Chi Zeng, Han Wan, et al. "A new species of Amolops (Anura: Ranidae) from China, with taxonomic comments on A. liangshanensis and Chinese populations of A. marmoratus." Zootaxa 4609, no. 2 (2019): 247–68. https://doi.org/10.11646/zootaxa.4609.2.3.

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Lyu, Zhi-Tong, Zeng, Zhao-Chi, Wan, Han, Yang, Jian-Huan, Li, Yu-Long, Pang, Hong, Wang, Ying-Yong (2019): A new species of Amolops (Anura: Ranidae) from China, with taxonomic comments on A. liangshanensis and Chinese populations of A. marmoratus. Zootaxa 4609 (2): 247-268, DOI: 10.11646/zootaxa.4609.2.3

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3

Ruan, Jing-Ya, Hui-Na Cao, Hong-Yu Jiang, et al. "Structural characterization of phenolic constituents from the rhizome of Imperata cylindrica var. major and their anti-inflammatory activity." Phytochemistry 196 (April 30, 2022): 1–13. https://doi.org/10.1016/j.phytochem.2021.113076.

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Ruan, Jing-Ya, Cao, Hui-Na, Jiang, Hong-Yu, Li, Hui-Min, Hao, Mi-Mi, Zhao, Wei, Zhang, Ying, Han, Yu, Zhang, Yi, Wang, Tao (2022): Structural characterization of phenolic constituents from the rhizome of Imperata cylindrica var. major and their anti-inflammatory activity. Phytochemistry (113076) 196: 1-13, DOI: 10.1016/j.phytochem.2021.113076, URL: http://dx.doi.org/10.1016/j.phytochem.2021.113076

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4

Wang, Hao-Tian, Feng-Bin Yu, Pu-Yang Zheng, et al. "Descriptions of three new species of Hemiphyllodactylus Bleeker, 1860 (Squamata: Gekkonidae) from Hainan Island, China." Zootaxa 5633, no. 2 (2025): 201–43. https://doi.org/10.11646/zootaxa.5633.2.1.

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Wang, Hao-Tian, Yu, Feng-Bin, Zheng, Pu-Yang, Zhang, Hao-Yu, Qi, Xu-Ming, Jiang, Zhao-Xuan, Li, Mao-Liang, Qi, Shuo, Song, Han-Ming, Yang, Hao-Cong, Huang, Ming-Hong, Li, Guo-Yi, Wang, Wei, Wang, Shi-Li, Mo, Yan-Ni, Xie, Feng, Li, Pi-Peng, Wang, Ying- Yong (2025): Descriptions of three new species of Hemiphyllodactylus Bleeker, 1860 (Squamata: Gekkonidae) from Hainan Island, China. Zootaxa 5633 (2): 201-243, DOI: 10.11646/zootaxa.5633.2.1, URL: https://doi.org/10.11646/zootaxa.5633.2.1

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5

Ying, You-Min, Lin-Yan Zhang, Xia Zhang, et al. "Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus." Phytochemistry 108 (December 31, 2014): 171–76. https://doi.org/10.1016/j.phytochem.2014.09.022.

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Ying, You-Min, Zhang, Lin-Yan, Zhang, Xia, Bai, Hai-Bo, Liang, Dong-E, Ma, Lie-Feng, Shan, Wei-Guang, Zhan, Zha-Jun (2014): Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus. Phytochemistry 108: 171-176, DOI: 10.1016/j.phytochem.2014.09.022, URL: http://dx.doi.org/10.1016/j.phytochem.2014.09.022

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6

Wang, Zhuo-Ren, Philippe Callac, Jun-Liang Zhou, Wen-Jin Fu, San-Han Dui, and Rui-Lin Zhao. "Edible species of Agaricus (Agaricaceae) from Xinjiang Province (Western China)." Phytotaxa 202, no. 3 (2015): 185–97. https://doi.org/10.11646/phytotaxa.202.3.2.

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Wang, Zhuo-Ren, Callac, Philippe, Zhou, Jun-Liang, Fu, Wen-Jin, Dui, San-Han, Zhao, Rui-Lin (2015): Edible species of Agaricus (Agaricaceae) from Xinjiang Province (Western China). Phytotaxa 202 (3): 185-197, DOI: 10.11646/phytotaxa.202.3.2, URL: http://dx.doi.org/10.11646/phytotaxa.202.3.2

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7

Song, Hai-Yan, Ping-An Zhong, Jiang-Lin Liao, Zhao-Hai Wang, Dian-Ming Hu, and Ying Jin Huang. "Junewangia aquatica (Junewangiaceae), a new species from freshwater habitats in China." Phytotaxa 336, no. 3 (2018): 272–78. https://doi.org/10.11646/phytotaxa.336.3.5.

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Song, Hai-Yan, Zhong, Ping-An, Liao, Jiang-Lin, Wang, Zhao-Hai, Hu, Dian-Ming, Huang, Ying- Jin (2018): Junewangia aquatica (Junewangiaceae), a new species from freshwater habitats in China. Phytotaxa 336 (3): 272-278, DOI: 10.11646/phytotaxa.336.3.5, URL: http://dx.doi.org/10.11646/phytotaxa.336.3.5

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8

Li, Xiao-Ling, Hai-Ying Yu, Xi Luo, et al. "Phylogeny of Phyllachora species on bamboo and P. cephalostachyi sp. nov. from China." Phytotaxa 514, no. 2 (2021): 158–66. https://doi.org/10.11646/phytotaxa.514.2.7.

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Li, Xiao-Ling, Yu, Hai-Ying, Luo, Xi, Wu, Hao, Zhao, Chun-Yan, Promputtha, Itthayakorn, Sun, Da-Feng (2021): Phylogeny of Phyllachora species on bamboo and P. cephalostachyi sp. nov. from China. Phytotaxa 514 (2): 158-166, DOI: 10.11646/phytotaxa.514.2.7, URL: http://dx.doi.org/10.11646/phytotaxa.514.2.7

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9

Jiang, Hai-ying, Chao-qun Hu, Hai-peng Yang, et al. "Morphology and phylogeny of Halamphora yongxingensis sp. nov. (Bacillariophyta), a new marine benthic diatom isolated from Yongxing Island, South China Sea." Phytotaxa 195, no. 1 (2015): 53–64. https://doi.org/10.11646/phytotaxa.195.1.3.

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Jiang, Hai-ying, Hu, Chao-qun, Yang, Hai-peng, Zhang, Lv-ping, Peng, Peng-fei, Luo, Peng, Zhao, Zhe, Xia, Jian-jun (2015): Morphology and phylogeny of Halamphora yongxingensis sp. nov. (Bacillariophyta), a new marine benthic diatom isolated from Yongxing Island, South China Sea. Phytotaxa 195 (1): 53-64, DOI: 10.11646/phytotaxa.195.1.3, URL: http://dx.doi.org/10.11646/phytotaxa.195.1.3

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10

H., R. E., Lu Xun, Yang Xianyi, and Gladys Yang. "The True Story of Ah Q / lu xun , a Q zheng zhuan: Chinese-English Bilingual Edition (zhong ying dui zhao)." Chinese Literature: Essays, Articles, Reviews (CLEAR) 24 (December 2002): 220. http://dx.doi.org/10.2307/823495.

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11

Ding, Qiao-Ling, Wan-Yi Zhao, Qian-Yi Yin, Hua-Gu Ye, Han-Zhang Song, and Wen-Bo Liao. "Begonia ehuangzhangensis (sect. Diploclinium, Begoniaceae), a new species from Guangdong, China." Phytotaxa 381, no. 1 (2018): 107–15. https://doi.org/10.11646/phytotaxa.381.1.14.

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Ding, Qiao-Ling, Zhao, Wan-Yi, Yin, Qian-Yi, Ye, Hua-Gu, Song, Han-Zhang, Liao, Wen-Bo (2018): Begonia ehuangzhangensis (sect. Diploclinium, Begoniaceae), a new species from Guangdong, China. Phytotaxa 381 (1): 107-115, DOI: 10.11646/phytotaxa.381.1.14, URL: http://dx.doi.org/10.11646/phytotaxa.381.1.14

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12

Yin, Hai-Xiang, Da-Peng Zhang, and Zhan Yin. "A new species of the genus Sinohaplotropis Cao et Yin, 2008 (Orthoptera, Acridoidea, Pamphagidae) from Amur River, Russia." Zootaxa 4822, no. 1 (2020): 139–43. https://doi.org/10.11646/zootaxa.4822.1.10.

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Yin, Hai-Xiang, Zhang, Da-Peng, Yin, Zhan (2020): A new species of the genus Sinohaplotropis Cao et Yin, 2008 (Orthoptera, Acridoidea, Pamphagidae) from Amur River, Russia. Zootaxa 4822 (1): 139-143, DOI: 10.11646/zootaxa.4822.1.10

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13

Zhang, Da-Peng, Hai-Xiang Yin, and Zhan Yin. "A new species of the genus Xya Latreille, 1809 from Shandong, China (Orthoptra, Tridctyloidea, Tridactylidae)." Zootaxa 4455, no. 3 (2018): 593–96. https://doi.org/10.11646/zootaxa.4455.3.17.

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Zhang, Da-Peng, Yin, Hai-Xiang, Yin, Zhan (2018): A new species of the genus Xya Latreille, 1809 from Shandong, China (Orthoptra, Tridctyloidea, Tridactylidae). Zootaxa 4455 (3): 593-596, DOI: 10.11646/zootaxa.4455.3.17

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14

Yin, Hai-Xiang, Wei-Xing Shen, and Zhan Yin. "--A--new--species--and--a--key--to--10--species--of--the--genus Lemba--Huang,--1983--(Orthoptera Catantopidae)--from--China--." Zootaxa 4894, no. 2 (2020): 287–91. https://doi.org/10.11646/zootaxa.4894.2.8.

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Yin, Hai-Xiang, Shen, Wei-Xing, Yin, Zhan (2020): --A--new--species--and--a--key--to--10--species--of--the--genus Lemba--Huang,--1983--(Orthoptera Catantopidae)--from--China--. Zootaxa 4894 (2): 287-291, DOI: 10.11646/zootaxa.4894.2.8

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15

Cao, Cheng-Quan, Hai-Xiang Yin, and Zhan Yin. "A new species of the genus Xya Latreille, 1809 from Jilin, China (Orthoptera, Tridctyloidea, Tridactylidae)." Zootaxa 5443, no. 1 (2024): 141–45. https://doi.org/10.11646/zootaxa.5443.1.9.

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Cao, Cheng-Quan, Yin, Hai-Xiang, Yin, Zhan (2024): A new species of the genus Xya Latreille, 1809 from Jilin, China (Orthoptera, Tridctyloidea, Tridactylidae). Zootaxa 5443 (1): 141-145, DOI: 10.11646/zootaxa.5443.1.9, URL: http://dx.doi.org/10.11646/zootaxa.5443.1.9

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16

Yuan, Fang-Yu, Zhuo-Ya Tang, Xue-Long Yan, et al. "Diversity of sesquiterpenoids from Stellera chamaejasme with neuroprotective effects." Phytochemistry 208 (April 30, 2023): 1–10. https://doi.org/10.1016/j.phytochem.2023.113588.

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Yuan, Fang-Yu, Tang, Zhuo-Ya, Yan, Xue-Long, Huang, Dong, Weng, Han-Zhuang, Huang, Jia-Luo, Fan, Run-Zhu, Chen, Ye, Yin, Sheng, Tang, Gui-Hua (2023): Diversity of sesquiterpenoids from Stellera chamaejasme with neuroprotective effects. Phytochemistry (113588) 208: 1-10, DOI: 10.1016/j.phytochem.2023.113588, URL: http://dx.doi.org/10.1016/j.phytochem.2023.113588

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17

Shen, Shunong. "A review on Ben Cao Gang Mu Ying Jiao Dui Zhao (《本草纲目影校对照》 A contrast between the photocopy and collation of compendium of Materia Medica)". Chinese Medicine and Culture 2, № 2 (2019): 77. http://dx.doi.org/10.4103/cmac.cmac_7_19.

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18

Han, Han, Xiaofeng Yang, Ying Zhao, et al. "Abstract 504: BPI-472372: a potent and orally bioavailable small molecule inhibitor of CD73 for cancer immunotherapy." Cancer Research 83, no. 7_Supplement (2023): 504. http://dx.doi.org/10.1158/1538-7445.am2023-504.

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Abstract CD73, also known as ecto-5'-nucleotidase, plays a major role in converting extracellular adenosine monophosphate (AMP) to immunosuppressive adenosine. It is frequently overexpressed across a variety of cancers. High adenosine level in the tumor microenvironment, predominantly signaling through the A2a/A2b receptors, suppresses innate and adaptive immune responses and mediates tumor immune evasion. CD73 overexpression is correlated with poor prognosis in several tumor types. Inhibition of CD73 to reduce adenosine production is a promising therapeutic approach for the treatment of cance

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19

Li, Zhengqing, Renqi Xu, Xiaofeng Yang, et al. "Abstract 6513: Discovery and characterization of a KRASG12C/D/V degrader with potent anti-tumor activity in KRASmut-driven preclinical models." Cancer Research 84, no. 6_Supplement (2024): 6513. http://dx.doi.org/10.1158/1538-7445.am2024-6513.

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Abstract KRAS mutations are one of the most common oncogenic drivers for multiple cancers. KRASG12X mutations are identified in approximately 25% of lung cancer, 24% of colorectal (CRC), and 79% of pancreatic ductal adenocarcinoma (PDAC). Although the approval of Sotorasib in 2021 by the FDA partially addressed the needs of patients with KRASG12C mutant, other mutations, such as G12D and G12V, still lack effective target therapies. Here, we report RD0255359, a proteolysis targeting chimera (PROTAC) KRASG12C/D/V degrader with highly potent cell viability and KRASG12C/D/V degradation ability. In

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Li, Zhengqing, Renqi Xu, Xiaofeng Yang, et al. "Abstract 6376: KRASmultidegrader BPI-585725 displays potent anti-tumor activity in KRAS-driven preclinical models." Cancer Research 85, no. 8_Supplement_1 (2025): 6376. https://doi.org/10.1158/1538-7445.am2025-6376.

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Abstract As a prominent oncogenic driver, KRAS mutation is prevalent in approximately 20-30% of cancer patients, particularly in colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC), where it accounts for roughly 45%, 90% and 35%, respectively. Although several KRAS G12C inhibitors are already on the market, they suffer from limited efficacy and short duration of response. Thus, eliminating the KRAS protein, rather than inhibiting KRAS holds hope for the long lasting clinical efficacy. Here, we introduce BPI-585725, a novel multiple KRAS (KRAS

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Yang, Xiang, Xiaoguan Zhu, Han Han, et al. "Abstract 4379: BPI-572270: An orally bioavailable and highly potent RAS (On) multi tri-complex inhibitor." Cancer Research 85, no. 8_Supplement_1 (2025): 4379. https://doi.org/10.1158/1538-7445.am2025-4379.

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Abstract KRAS mutations are oncogenic drivers occur in approximately 20%-30% of all cancers with particularly high frequencies observed in pancreatic cancer (∼90%), non-small cell lung cancer (∼35%), and colorectal cancer (∼45%). While approved KRASG12C inhibitors have demonstrated clinical benefits in patients with KARSG12C mutation, other prevalent KRAS mutations, such as KRASG12D/G12V/G13D/Q61H, remain a significant therapeutic challenge. Here we present BPI-572270, a highly potent Cyclophilin A-dependent RAS(On)multi inhibitor with favorable oral bioavailability designed to target those di

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Molel, Leshinka Leshinka, and Thomas Fuller. "Design of Lithium Metal Anode and Other High-Capacity Alloy Anodes Solid-State Batteries in Context of Contact Loss between Anode and Solid Electrolyte Separator." ECS Meeting Abstracts MA2024-01, no. 27 (2024): 1463. http://dx.doi.org/10.1149/ma2024-01271463mtgabs.

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Cyclic volume changes and non-uniform electrodeposition/stripping, among other cycling-induced chemo-mechanical degradation of lithium metal and lithium-alloy solid state batteries, lead to contact loss between the anode and the solid electrolyte separator[1, 2]. In-operando experiments have shown ac- celerated short-circuiting behavior due to contact loss in “anode-free” solid-state batteries[2]. Simulations reveal the relationship between active area fraction and the ratio of effective conductivities in made-up active area configurations[3]. Through modeling experiments using imputed active

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Wu, Dong, Ying Qing, Keith Leung, et al. "Abstract 1035: Western lifestyle leads to obesity and cancer via a common factor FTO." Cancer Research 85, no. 8_Supplement_1 (2025): 1035. https://doi.org/10.1158/1538-7445.am2025-1035.

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Abstract FTO, the first identified RNA N6-methyladenosine (m6A) demethylase, has been reported by our group to play an oncogenic role in acute myeloid leukemia (AML) and by others in various solid tumors, including colorectal and liver cancers. Additionally, FTO was the first gene identified through genome-wide association studies (GWAS) to be associated with obesity risk, with evidence linking elevated FTO expression to increased food intake and obesity development. While obesity is a recognized risk factor for cancer, whether FTO serves as a shared factor driving both obesity and cancer rema

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Qing, Ying, Dong Wu, Yangchan Li, et al. "Abstract 4843: TET2 oxidizes chromatin-associated regulatory RNA m5C to potentiate anti-tumor immunity." Cancer Research 85, no. 8_Supplement_1 (2025): 4843. https://doi.org/10.1158/1538-7445.am2025-4843.

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Current immunotherapies have shown limited success in treating acute myeloid leukemia (AML) due to immune evasion, which often stems from epigenetic dysregulation of immune-related pathways. TET2, a well-studied DNA 5-methylcytosine dioxygenase, is frequently mutated and recognized as a tumor suppressor in AML. While TET2 deficiency in hematopoietic stem/progenitor cells (HSPCs) has been associated with elevated inflammation, TET2 has also been reported to promote inflammatory interferon (IFN) signaling in solid tumors, enhancing tumor responses to immunotherapies. Despite these findings, the

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Cao, Y., J. Ruan, J. Kang, et al. "POS0335 EXOSOMES TRANSMIT DAMAGE SIGNALS FROM INFRAPATELLAR FAT PAD AND EXACERBATE CHONDROCYTE SENESCENCE IN OSTEOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 413.1–414. http://dx.doi.org/10.1136/annrheumdis-2023-eular.281.

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BackgroundInfrapatellar fat pad (IPFP) is closely associated with the development and progression of knee osteoarthritis (OA)[1-5], but the underlying mechanism remains unclear.ObjectivesThis study aims to investigate the role and regulatory mechanisms of osteoarthritic infrapatellar fat pad (IPFP) tissue-derived exosomes (IPFP-Exos) in chondrocytes senescence and osteoarthritis (OA) progression.MethodsThe IPFP were collected from late-stage OA patients with knee arthroplasty. The role of endogenous osteoarthritic IPFP-Exos was measured in human IPFP explants coculturing with chondrocytes and

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Li, Qiao, Xian Wang, Ying Cheng, et al. "Abstract P4-01-07: FS-1502, an anti-HER2 ADC, in Patients with HER2-Expressing Advanced Solid Tumors: A Phase 1a Dose-Escalation Study." Cancer Research 83, no. 5_Supplement (2023): P4–01–07—P4–01–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-01-07.

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Abstract Background: FS-1502 is a HER2-targeting antibody drug-conjugate with a cleavable β-glucuronide linker and an antimitotic agent (monomethyl auristatin F) which showed promising antitumor activity in preclinical studies. We are evaluating the safety and tolerability of FS-1502 in patients with HER2-expressing advanced solid tumors (NCT03944499). Methods: Patients with HER2-expresssing advanced solid tumors who had failed prior standard of care therapies were enrolled in a single-arm, open-label, dose-escalation phase Ia study in China. FS-1502 was given IV once in 21-day or 28-day cycle

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Tan, Brandon, Wei Liu, Keren Zhou, et al. "Abstract 2188: The N6-methyladenosine reader YTHDC1 is essential for TGF-beta-mediated metastasis of triple negative breast cancer." Cancer Research 82, no. 12_Supplement (2022): 2188. http://dx.doi.org/10.1158/1538-7445.am2022-2188.

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Abstract Metastatic triple negative breast cancer (TNBC) patients have a 5-year survival rate of just 12%. Therefore, there is an urgent need to discover novel molecular mechanisms that contribute to TNBC metastasis such as N6-methyladenosine (m6A) RNA modification. To do this, we conducted a selective CRISPR-cas9 screen of 14 m6A-regulators and identified an m6A reader protein, YTHDC1, as an essential gene for the survival of MDA-MB-231 cells. The Cancer Genome Atlas (TCGA) dataset showed that patients with poorer prognosis had elevated YTHDC1 expression, which supports a tumor-promoting role

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Han, Li, Lei Dong, Keith Leung, et al. "Abstract 3617: METTL16 drives leukemogenesis and maintains leukemia stem cell self-renewal via reprogramming BCAA metabolism." Cancer Research 82, no. 12_Supplement (2022): 3617. http://dx.doi.org/10.1158/1538-7445.am2022-3617.

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Abstract Background: As the most prevalent internal decorations in mammalian mRNA, N6-methyladenosine (m6A) has been reported to be involved in many physiological and pathological processes, including acute myeloid leukemia (AML). METTL3 and METTL14, the well-recognized m6A methyltransferase complex, contribute to AML. METTL16 is a recently identified m6A methyltransferase that has been reported to deposit m6A in a few targets. While, unlike METTL3/14, the biological functions of METTL16 are largely unknown. Here, we explored the function and mechanism of METTL16 in AML pathogenesis and evalua

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Zhao, Zhicong, Lei Dong, Li Han, et al. "Abstract 5685: Recognition of internal mRNA N7-methylguanosine by QKI shuttles transcripts into stress granules and modulates drug resistance." Cancer Research 82, no. 12_Supplement (2022): 5685. http://dx.doi.org/10.1158/1538-7445.am2022-5685.

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Abstract Introduction: Albeit that over 170 types of chemical modifications have been identified in RNAs, the biological functions of most of those decorations are still elusive. N7-methylguanosine (m7G), routinely occurring at the 5’ cap of mRNA or within tRNA and rRNA, also exists in internal mRNA. However, the “reader” proteins that recognize internal mRNA m7G and regulate the metabolism and fate of target mRNAs have yet to be identified. Here, we aim to identify the reader(s) of internal mRNA m7G and elucidate the biological function. Methods: To identify internal m7G reader(s), we utilize

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Ying, Han, Chao Yao, Cheng Fang, et al. "Abstract 1328: AccuBaseTM (ceBE), a second-generation high-fidelity base editor, can proficiently modify genes in a human primary NK cells with minimizing off-target effect." Cancer Research 84, no. 6_Supplement (2024): 1328. http://dx.doi.org/10.1158/1538-7445.am2024-1328.

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Abstract Natural Killer (NK) cells hold great promise for cancer therapy owing to their innate ability to detect cells expressing signs of stress or infection. However, NK cell-based therapeutics face significant challenges: limited expansion and genetic modification resistance. In response to these challenges, we present our pioneering work in the development of Base Editing-Directed NK (BED-NK) cell products, referred to as NK510, which is an off-the-shelf allogeneic cell therapy product containing peripheral blood mononuclear cell (PBMC)-derived TIGIT knock-out NK cells. Through a meticulou

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Le, Xiuning, Alexander Spira, Shirish Gadgeel, et al. "Abstract CT152: FURTHER: A global study to evaluate furmonertinib in patients with EGFR mutant NSCLC including uncommon EGFR mutations." Cancer Research 84, no. 7_Supplement (2024): CT152. http://dx.doi.org/10.1158/1538-7445.am2024-ct152.

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Abstract Background: Furmonertinib (AST2818) is an oral, highly brain-penetrant, and broadly active mutation-selective epidermal growth factor receptor (EGFR) inhibitor engineered for broad activity and selectivity across EGFR mutations (mts) (Musib et al., NACLC 2022). Furmonertinib is approved in China for first-line advanced NSCLC with EGFR Ex19del or L858R mts based on the positive Phase 3 study (FURLONG) versus gefitinib. Furmonertinib has also demonstrated promising interim efficacy and safety in patients (pts) with NSCLC with EGFR exon 20 insertion (ex20ins) mts with a confirmed overall

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Yao, Herui, Min Yan, Zhongsheng Tong, et al. "Abstract PS8-08: Efficacy and safety of SHR-A1811, an anti-HER2 antibody-drug conjugate (ADC), in 391 heavily pretreated multiple solid tumors with HER2-expression or mutations: a global, multi-center, first-in-human, phase 1 study." Clinical Cancer Research 31, no. 12_Supplement (2025): PS8–08—PS8–08. https://doi.org/10.1158/1557-3265.sabcs24-ps8-08.

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Abstract Background: SHR-A1811, an anti-HER2 ADC comprising trastuzumab, a cleavable linker, and the topoisomerase I inhibitor payload SHR169265, has shown substantial tumor response and a manageable safety profile in heavily treated multiple solid tumors with HER2 expression or mutations (Yao. et al., JCO, 2024). Here we present for the first time the progression-free survival (PFS) analysis results of SHR-A1811 and updated safety results, including an additional 1-year of follow-up and an expanded cohort from 307 to 391 patients. Methods: Patients eligible for this study had HER2-expressing

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Liu, Xiyu, Ying Xu, Xiuzhi Zhu, et al. "Abstract PS3-01: Tislelizumab plus sitravatinib and nab-paclitaxel in patients with untreated locally recurrent or metastatic triple negative breast cancer (TNBC): updated efficacy and safety results." Clinical Cancer Research 31, no. 12_Supplement (2025): PS3–01—PS3–01. https://doi.org/10.1158/1557-3265.sabcs24-ps3-01.

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Abstract Background: The PD-(L)1 inhibitor-chemotherapy combination has established efficacy as first-line treatment for PD-L1 positive metastatic TNBC, but novel treatment regimens are still needed to improve the clinical outcomes for the whole population of TNBC in the first-line setting. Emerging evidence indicates that the combination of anti-angiogenic therapies and PD-(L)1 blockade may act synergistically, thereby potentiating enhanced antitumor activity. Sitravatinib (Sitra) is a spectrum-selective tyrosine kinase inhibitor that could potently inhibit split kinase receptors and TAM rece

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Hazem, El-Akabawy, Omer Emad, Mowafy Hossam, Nessim Iris, and Maghraby Ahmed. "Clinical Evaluation of plasma Gelsolin as a novel marker for sepsis: comparison with Procalcitonin regarding early diagnosis and prognosis in septic patients." Biolife 5, no. 4 (2022): 416–27. https://doi.org/10.5281/zenodo.7371656.

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<strong>ABSTRACT</strong> Gelsolin is an actin-binding plasma protein that is part of an 'actin-scavenging' system. Gelsolin serves a protective role against tissue injuries and may play a crucial role in the pathophysiology of sepsis. The present study was designed to evaluate the diagnostic utility and the prognostic value of pGSN in the critically ill septic patients. A total of 80 critically ill septic patients and another 40 critically ill non septic patients were included in this observational prospective randomized study. All patients were subjected to a measurement of pGSN and

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Amin, Adam Aliathun, and Eva Imania Eliasa. "Parenting Skills as The Closest Teacher to Early Childhood at Home." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 312–30. http://dx.doi.org/10.21009/jpud.172.09.

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Parents play an important role in the development of their children. This research reflects the role of parents in developing children. Through four stages of identification, screening, eligibility, and acceptable results, this method uses a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The findings from the fourteen articles examined show that parenting skills play an important role in a child's growth and development from birth to death. The determining factor in the development of physical, motoric, moral, language

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Yang, Ning, Xiaojun He, Cuixia Yin, and Lihua Zhao. "Clinical analysis of 33 cases with neonatal cerebral infarction." Pakistan Journal of Medical Sciences 37, no. 7 (2021). http://dx.doi.org/10.12669/pjms.37.7.4720.

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Objective: To investigate the etiology, clinical manifestations, diagnosis, treatment and prognosis of neonatal cerebral infarction (NCI) to further improve the understanding of the disease. Methods: Clinical data and follow-up results of 33 cases of NCI in neonatal intensive care unit of a first-class hospital from September 2009 to September 2019 were retrospectively analyzed. Results: All 33 patients were diagnosed with NCI by MRI. Among them, 31 cases (93.94%) were full-term infants, 25 cases (75.76%) were mother’s first birth, and 18 (54.55%) cases were males. Pregnancy compli

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Ori, Tavor. "Spring and Autumn annals of Master Lü." Database of Religious History, June 27, 2024. https://doi.org/10.5281/zenodo.12573218.

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A late Warring States text commissioned by Lü Buwei 呂不韋. According to his biography in Sima Qian's 司馬遷Records of the Historian 史記, Lü was a wealthy merchant in his home state of Wei 衞 when he met the Qin 秦 prince Zichu 子楚, who was held as a political hostage in the northern state of Zhao 趙. When the prince ascended to the throne in 249 BCE, he appointed Lü as assistant chancellor. When the king died two years later, his young son Ying Zheng 嬴政, who succeeded him, appointed Lü as Prime Minister and Regent to the throne, a position that he held between 247 and 235 BCE. During his tenure, Lü asse

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Huu Tho, Nguyen, Trang Thanh Tu, Trac Minh Nhan, Pham Hong Cam, and Pham Thi Thi. "The Geometries and Stabilities of Neutral and Anionic Vanadium Doped Germanium Clusters VGen0/-( n = 9 - 13): Density Functional Theory Investigations." VNU Journal of Science: Natural Sciences and Technology 35, no. 1 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4827.

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The geometries, stabilities of VGen0/- (n = 9 - 13) clusters were systematically studied by the density functional theory (DFT) using the BP86 functional and LANL2DZ basis set. Several possible multiplicities of each cluster were tested to determine the most stable structure among the isomers. The average binding energy per atom, fragmentation energy, second order energy difference and HOMO-LUMO gaps were evaluated. The results indicated that the neutral and anionic clusters possess higher stability when n = 10 and 12. The vertical detachment energy (VDE) and adiabatic detachment energy (ADE)

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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Victoria, L. Fox1 Mariofana Milanova2 and Salim Al-Ali. "A MORPHOLOGICAL MULTIPHASE ACTIVE CONTOUR FOR VASCULAR SEGMENTATION." August 22, 2018. https://doi.org/10.5121/ijbb.2013.3301.

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International Journal on Bioinformatics & Biosciences (IJBB) Vol.3, No.3, September 2013 DOI: 10.5121/ijbb.2013.3301 1 A MORPHOLOGICAL MULTIPHASE ACTIVE CONTOUR FOR VASCULAR SEGMENTATION Victoria L. Fox1 , Mariofana Milanova2 , and Salim Al-Ali3 1Department of Applied Science, University of Arkansas at Little Rock, USA 2Department of Computer Science, University of Arkansas at Little Rock, USA 2Department of Computer Science, University of Arkansas at Little Rock, USA ABSTRACT This paper presents a morphological active contour ideal for vascular segmentation in biomedical images. The unenh

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