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Artykuły w czasopismach na temat „Anti-Convulsion Drugs”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Sadgunottama goud kamparaj, Kudagi B L, Karikal H P, Muthiah N S, and Pravin Kumar R. "Evaluation of the anticonvulsant activity of the phosphodiesterase III inhibitor cilostazol in the animal model of epilepsy." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 3391–95. http://dx.doi.org/10.26452/ijrps.v11i3.2476.

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The present study is objected to evaluate the anticonvulsant activity of the phosphodiesterase III inhibitor cilostazol in the animal model of epilepsy. Conventional anti-epileptic rodent models like Maximal Electric Shock (MES)- induced convulsions and Pentylenetetrazol (PTZ) induced convulsions were used. The animals were randomly divided into six groups, with six rats in every group. Here anti-epileptic activity of cilostazol with two different doses (10 mg/kg i.p and 20 mg/kg i.p) was compared with standard drug and standard drug + Cilostazol two different doses (10 mg/kg i.p and 20 mg/kg

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Tanaka, Kazuhiko, Masakatsu Nozaki, Takashi Nose, Kimio Yasuda, Kaito Tsurumi, and Hajine Fujimura. "Convulsion induced by combination with new quinolone antimicrobials and anti-inflammatory drugs." Japanese Journal of Pharmacology 46 (1988): 240. http://dx.doi.org/10.1016/s0021-5198(19)57560-6.

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Saad, Shaban E. A., Suhera M. Aburawi, Ahlaam A. Rahoumh, Ahlaam A. Rahoumh та Akram Abdraheem. "Influence of β- blockers on the activity of some anti-epileptic drugs on convulsions induced by picrotoxin in mice". Libyan Journal of Medical Research 16, № 2 (2022): 127–34. http://dx.doi.org/10.54361/ljmr.16210.

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Adrenergic β-receptor blockers are widely used in clinic for the management of cardiovascular disease and some other illnesses. However, this group of drugs known to cause central nervous system side effects such as drowsiness, sleep disturbance, hallucination, migraine and tremors. As anti-epileptic drugs exert their action mainly through the inhibition of the central nervous system to decrease the firing and the excitability of neurons. Accordingly, β-blockers might influence the pharmacological activity of anti-epileptic drugs. Aim:The aims of this study is to investigate the influence of β

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C., Muralidhar, Vijay Prasad S., and Sridhar I. "Anticonvulsant effect of nifedipine, dizepam and in combination on pentylenetetrazol induced experimental models of epilepsy on albino rats." International Journal of Basic & Clinical Pharmacology 6, no. 11 (2017): 2577. http://dx.doi.org/10.18203/2319-2003.ijbcp20174634.

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Background: In many patients, the presently available antiepileptic drugs such as phenobarbital, phenytoin, benzodiazepines, sodium valproate, etc., are unable to control seizures efficiently and the problem of adverse effects has also not been circumvented completely and approximately 30% of the patients continue to have seizures with current antiepileptic drugs therapy. Hence, search should continue to develop newer, more effective, and safer neuro-protective agents for treatment of epilepsy. Aim of the study was to investigate the activity of nifedipine, the dihydropyridine calcium channel

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Zaib-un-nissa*, Muhammad Iqbal Suhail Ahmed Almani Aatir H. Rajput Muhammad Muneeb Hamid Memon Syed Jehangir and Shahrukh Shaikh. "CASUAL COMPARATIVE ANALYSIS OF GINGIVAL INDEX SCORE AMONG EPILEPTIC PATIENTS USING CARBAMAZEPINE, SODIUM VALPROATE AND PHENYTOIN." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1565–69. https://doi.org/10.5281/zenodo.817621.

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Abstract: Objective: This research hoped to compare the periodontal health of epileptic patients using three different anti-epilepsy drugs, namely, carbamazepine, phenytoin and sodium valproateusing the gingival index score. Methodology: This casual comparative analysis of periodontal health was conducted at Liaquat University Hospital from January to March (2017) upon 3 groups of patients, each using a different anti-epileptic drug. The groups comprised of 15 patients each and the groups were matched for age, sex and duration of drug therapy. All recordings made on the gingival index score on

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Sikarwar, Saurav Singh, Kratika Daniel, and Neetesh Kumar Jain. "Synthesis, Characterization and Anti-Convulsant Activity of Novel Substituted Oxadiazole Derivatives." International Journal of Medical Sciences and Pharma Research 8, no. 2 (2022): 55–59. http://dx.doi.org/10.22270/ijmspr.v8i2.39.

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Seizures are sudden, transitory, and uncontrolled episodes of brain dysfunction resulting from abnormal discharge of neuronal cells with associated motor, sensory or behavioral changes. Anticonvulsants (also commonly known as antiepileptic drugs or as ant seizure drugs) are a diverse group of pharmaceuticals used in the treatment of epileptic seizures. Anticonvulsants are also increasingly being used in the treatment of bipolar disorder, since many seem to act as mood stabilizers, and for the treatment of neuropathic pain. Anticonvulsants suppress the rapid and excessive firing of neurons duri

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Vishal N Kushare and Saravanan S. "Invitro and invivo evaluation of anticonvulsant herbal drug loaded self nano emulsifying drug delivery system." International Journal of Pharmaceutical Research and Life Sciences 6, no. 2 (2018): 38–44. http://dx.doi.org/10.26452/ijprls.v6i2.1279.

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The aim of present study was to formulate and evaluate emulsifying drug delivery system (SNEDDS) of poorly and herbal drug like () extract, which was extracted from Coriandrum seeds by using ( method extraction process). are isolated by using column chromatography and concentrated under reduced pressure by using rotary flash evaporator., an essential of Coriandrum with anti-epileptic activity.the oil phase like , Tween 80 and PEG-200 were selected as and respectively for the formulation of SNEDDS(9 formulation). all the formulation S9 shows maximum cumulative amount of drug release of about97.

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Kathuria, Ishita, and Bhupesh Singla. "Anti-tumor efficacy of Calculus bovis: Suppressing liver cancer by targeting tumor-associated macrophages." World Journal of Gastroenterology 30, no. 38 (2024): 4249–53. http://dx.doi.org/10.3748/wjg.v30.i38.4249.

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Despite significant advances in our understanding of the molecular pathogenesis of liver cancer and the availability of novel pharmacotherapies, liver cancer remains the fourth leading cause of cancer-related mortality worldwide. Tumor relapse, resistance to current anti-cancer drugs, metastasis, and organ toxicity are the major challenges that prevent considerable improvements in patient survival and quality of life. Calculus bovis (CB), an ancient Chinese medicinal drug, has been used to treat various pathologies, including stroke, convulsion, epilepsy, pain, and cancer. In this editorial, w

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Xie, Xingcheng, Han Guo, Juan Liu, Junbao Wang, Huihui Li, and Zhongyuan Deng. "Edible and Medicinal Progress of Cryptotympana atrata (Fabricius) in China." Nutrients 15, no. 19 (2023): 4266. http://dx.doi.org/10.3390/nu15194266.

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As an important resource insect, the Cryptotympana atrata is widely distributed in the eastern and central parts of China. The cicada slough is one of the traditional crude drugs in East Asia, and the main component is polysaccharide, which has the functions of anti-convulsion, relieving asthma and improving lipid metabolism. The parasitoid fungus Cordyceps cicadae, which grows inside the cicada nymphs and forms the fruiting bodies on the surface of the host’s carcass, is also known as the “cicada flower” in China. The Cordyceps cicadae is another old, traditional Chinese medicine, which has b

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Preethi, Preethi, G. Sumathy, and Venkatalakshmi Venkatalakshmi. "Nardostachys Jatamansi DC: A Medicinal Treasure in Peril(A Review)." Journal of Neonatal Surgery 14, no. 9S (2025): 250–59. https://doi.org/10.52783/jns.v14.2653.

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The miraculous but endangered plant, Nardostachys Jatamansi DC is a highly medicinal value, primitive, and therapeutic herbal plant used in both daily self-care and professionally managed health care. It is an endangered species due to overexploitation of its rhizomes for medicinal, aromatic uses, folk medicine, overgrazing, loss of habitats, and forest degradation. All the parts of the plants are used for various therapeutic activities like Alzheimer’s, anti-convulsion, antioxidants, hair growth, hepatoprotective, Parkinson’s, etc. Phytosterols, terpenoids, flavonoids, and phenolic compounds

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Goel, Radha, and Prasoon Saxena. "Pycnogenol Protects against Pentylenetetrazole-Induced Oxidative Stress and Seizures in Mice." Current Clinical Pharmacology 14, no. 1 (2019): 68–75. http://dx.doi.org/10.2174/1574884714666181122110317.

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Background:Epilepsy is one of the most common and severe brain disorders in the world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability and inhibition. Oxidative stress is a biochemical state in which reactive oxygen species are generated and associated with various diseases including epilepsy. Pycnogenol, a polyphenol obtained from the pine tree and has antioxidant & anti-inflammatory activity. So, the aim of the study was to evaluate the effect of Pycnogenol on pentylenetetrazole (PTZ)-induced seizures in mice.Methods:The mice of swiss str

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Rout, Anima, Siddhartha Goutam, Elisha Paikray, Chaitali Pattanayak, and Vedvyas Mishra. "Nociceptive Analgesic and Anxiolytic Effects of Ondansetron in Wistar Rats: A Prospective Observational Study." International Journal of Pharmaceutical and Clinical Research 15, no. 3 (2023): 1480–89. https://doi.org/10.5281/zenodo.12791085.

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<strong>Introduction: </strong>Serotonin plays an important role in pathogenesis of many diseases. Ondansetron is a selective 5HT3 antagonist used in patients with nausea and vomiting. It has also shown effectiveness in treatment of epilepsy, severe neuropathic pain, anxiety attacks & CNS-related disorders. The aim of this study was to evaluate the anticonvulsant, anxiolytic & antinociceptive effect of ondansetron in rats. <strong>Materials: </strong>Rats were treated with different doses of ondansetron intraperitoneally (i.p. – 0.5mg/kg, 1mg/kg and 2mg/kg) , pheny

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Naidu, Sushma V., Harsha R., and Jyothsnya S. "To evaluate the anticonvulsant activity of ethanolic extract of Moringa oleifera (drumstick leaves) in albino mice." International Journal of Basic & Clinical Pharmacology 6, no. 10 (2017): 2491. http://dx.doi.org/10.18203/2319-2003.ijbcp20174382.

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Background: To evaluate the anti-convulsant activity of ethanolic extract of Moringa oleifera (Drum stick leaves) in seizure induced albino mice and to compare it with standard drug Sodium valproate.Methods: Swiss albino mice of either sex weighing around 25-30g were randomly selected and divided into four groups of six mice each. Group 1: control- treated with gum acacia. Group 2: Standard - Valproic acid 40mg/kg body weight. Group 3: T1- ethanolic extract of Moringa oleifera (150mg/kg). Group 4: T2 - ethanolic extract of Moringa oleifera (300mg/kg). All drugs were administered orally one hou

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Rezende, Getúlio Leonel de. "Survey on the clinical trial results achieved in Brazil comparing praziquantel and oxamniquine in the treatment of mansoni schistosomiasis." Revista do Instituto de Medicina Tropical de São Paulo 27, no. 6 (1985): 328–36. http://dx.doi.org/10.1590/s0036-46651985000600006.

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A random, double-blind, parallel group clinical trial program was carried out to compare praziquantel, a recently developed anti-helmintic drug, and oxamniquine, an already established agent for treating mansoni schistosomiasis. Both drugs were administered orally as a single dose, on the average, praziquantel 55 mg/kg and oxamniquine 16 mg/kg BWT. The diagnosis and the parasitological follow-up lasting for a minimum of six months, were based on stool examinations according to Kato/Katz technique. A patient was considered cured if all results were negative and if he had performed at least thre

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OKUMURA, Shunichi, Yoko ISHIHARA, and Hirotoshi ECHIZEN. "Detection of Signals of Convulsion-inducing Effect for Fluoroquinolone Antibiotics Alone and with Co-administration of Nonsteroidal Anti-inflammatory Drugs in Association with Aging Using Japanese Adverse Drug Event Reporting Database." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 50, no. 5 (2019): 203–9. http://dx.doi.org/10.3999/jscpt.50.203.

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Fukai, Junya, Takahiro Sasaki, Toshikazu Yamoto, et al. "COT-1 Clinical Questions and Answers about Glioma-Related Epilepsy (GRE): Real-world data in Wakayama Medical University Hospital." Neuro-Oncology Advances 3, Supplement_6 (2021): vi28. http://dx.doi.org/10.1093/noajnl/vdab159.110.

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Abstract Introduction: In glioma patients, epilepsy not infrequently occurred and anti-epileptic drugs (AEDs) are commonly used. In this study, we revealed the real-world data on clinical practice of glioma-related epilepsy in Wakayama Medical University Hospital (WMUH). Methods. We collected clinical and molecular data of glioma patients operated at WMUH from January 1996 to December 2020 and analyzed the data to answer clinical questions as follows: 1) location/histology related GRE, 2) molecular features related GRE, 3) prophylactic AEDs and postoperative seizure, 4) tumor progression and c

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Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "Drugs and Therapies for Cerebral Palsy: A Comprehensive Overview." Journal of Advances in Ayurveda, Yoga, Homeopathy and Naturopathy 2, no. 1 (2024): 6–9. https://doi.org/10.5281/zenodo.10622666.

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<em>Cerebral palsy (CP) is a neurological disorder influencing coordination, movement and posture because of the damage or abnormal development of the brain. Muscle relaxant namely baclofen shows its action on the central nervous system (CNS) to decrease muscle spasticity, a common symptoms in CP. Baclofen increases inhibitory neurotransmitters, resulting in reduced Muscle tone. CP patients may feel seizures and anti convulsant namely phenobarbital and valproic acid stop convulsants and increase overall neurological stability. An injection of botulinum toxin injections namely Botox takes place

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Naboka, Olga, Alla Kotvitska, Alina Volkova, et al. "Study of analgesic and myotropic spasmolytic activity of alkylcarb." ScienceRise: Biological Science, no. 2(35) (June 30, 2023): 4–11. http://dx.doi.org/10.15587/2519-8025.2023.285648.

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The work is devoted to the search for new biologically active substances in a series of alkylamides of dihydroquinoline-3-carboxylic acid. Analgesic properties of 30 newly synthesized substances were studied, which made it possible to identify the leader compound (provisional name alkylcarb) and recommend its effectiveness for further research as an antispasmodic agent for pain relief. It has been established experimentally, that the substance alkylcarb exhibits concentration-dependent vasodilatory properties in vitro on segments of the thoracic aorta of rats. The data, obtained in the work, j

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Hiremath, Sharanabasayyaswamy B., and Priya G. "Evaluation of zinc as anti-asthma agent: a preclinical study on guinea pigs." International Journal of Basic & Clinical Pharmacology 6, no. 8 (2017): 1943. http://dx.doi.org/10.18203/2319-2003.ijbcp20173275.

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Background: The role of intravenous magnesium sulfate in acute asthma is restricted to severe and resistant cases while that of zinc as prophylactic agent. What is quite interesting is to know the benefits of zinc in acute attack of asthma and that of magnesium as prophylactic agent. The objective of the study was to analyze the bronchodilatory effects of zinc sulfate and prophylactic role of magnesium sulfate using a preclinical model of histamine and acetylcholine induced acute bronchial asthma in conscious guinea pigs.Methods: Animals were exposed to histamine diphosphate (1%) and acetylcho

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Vikas, R. Patil* Vinay V. Sarode Samir B. Tadvi Bhushan P. Patil Vaishali Badgujar Shweta V. Rane Kunal M. Jadhav. "A Review on Various Analytical Methodologies for Buspirone." Int. J. in Pharm. Sci. 1, no. 6 (2023): 56–64. https://doi.org/10.5281/zenodo.8033198.

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Buspirone is a psychotropic drug which belongs to the class of compounds known as azaspirodecanediones. Buspirone used primarily as an anxiolytic. It specifically used for generalized anxiety disorder. As an anxiolytic drug buspirone is as potent as benzodiazepines, but it does not cause the adverse side effects, for example sedation, anti-convulsion or muscle relaxation. Buspirone was first approved in 1986 by USFDA. Therefore, the main objective of this analysis of Buspirone in pharmaceutical and biological formulation is in both qualitative and quantitative terms. In this review article, we

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Singh Bora, Kundan, and Kanupriya Kumari. "Evaluation of Anti-epileptic Activity of Cyanthillium cinereum (L.) H. Rob. Leaves in the Experimental Pentylenetetrazole-induced Epileptic Model." Central Nervous System Agents in Medicinal Chemistry 25 (May 27, 2025). https://doi.org/10.2174/0118715249352799250512015642.

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Background: Epilepsy is a common and frequently devastating disorder affecting millions of people. According to a recent survey, 1-2% of the Indian population suffers from major mental disorders and 5% suffers from minor mental disorders. Epilepsy is among those mental disorders that affect 30 million people worldwide. Currently, the treatment of epilepsy involves agents which modulate sodium-ion channels, enhance GABAergic transmission, and agents with multiple modes of action. Various classes of synthetic drugs are used to treat epilepsy, but these drugs are often challenged due to their unw

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Otimenyin, Sunday O., and Uche A. Osunkwo. "Diffuse Transcranial Electrical Stimulation (DTES)-induced hypermotility and convulsion: A model for screening drugs with anti-convulsant properties." Journal of Pharmacy & Bioresources 1, no. 1 (2005). http://dx.doi.org/10.4314/jpb.v1i1.32052.

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Saksham Kaldante, Shaibaj Pathan, Akshada Gund, Pratik Datir, and Gadge Shubham C. "Medicinal Plants Used to Treat Epilepsy." International Journal of Advanced Research in Science, Communication and Technology, June 30, 2022, 694–98. http://dx.doi.org/10.48175/ijarsct-5622.

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Epilepsy is a neuropsychological disorder, in which occurs due to over release of neurotransmitter substance. Epilepsy is different from the seizures, a seizure occurs due to abnormal and excessive hyper synchronous release from an aggregate CNS. There are lot of drugs available in market to treat epilepsy. But the major problem behind these drugs is patient faces chronic side effects. There are number of patients who faces resistant to antiepileptic drugs. Since from the ancient time, plants are used by the people to treat epileptic seizures. Different herbs plays vital role in prevention and

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Panaskar, Amit N., Ashish Jain, and Pradeep Kumar Mohanty. "Synthesis and Evaluation of Anti-inflammatory Activity of Some Chalcone Hydrazide Derivatives." Journal of Pharmaceutical Research International, February 25, 2022, 18–26. http://dx.doi.org/10.9734/jpri/2022/v34i15b35716.

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Aim: Chalcones are part of the selected group of chemical compounds related with diverse pharmacological activities such as antimicrobial, antiviral, antitumor, convulsion, anxiety, anti-inﬂammatory, andanalgesic. The aim of this study was to synthesize chalcones hydrazide derivatives and to evaluate their anti-inflammatory activity in the model of carrageenan induced edema in rats. Methods: The chalcone hydrazide derivatives were prepared by treating Isonicotinyl and Nicotinyl hydrazide with respective parent chalconeand environmentally friendly solvents with 78–85% yields in approximat

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Coulibaly, Adjaratou C., W. L. M. Esther B. Kabre, Tata K. Traore, et al. "Phytochemical Screening, Anti-inflammatory and Analgesic Activities of Root Barks from Acacia macrostachya Reichenb. Ex DC. (Fabaceae)." Annual Research & Review in Biology, July 31, 2020, 76–83. http://dx.doi.org/10.9734/arrb/2020/v35i730249.

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Aims: Acacia macrostachya Reichenb. ex DC. (Fabaceae) is used in traditional medicine for the treatment of many pathologies including diarrhea, malaria with convulsion and fevers, snake bites, vomiting, nausea, dysenteric syndrome and choleriformis, inflammatory diseases and old wounds. The purpose of this study was to carry out the phytochemical screening, to assess the general acute toxicity, the anti-inflammatory and analgesic activities of the dichloromethane extract of A. macrostachya root barks in order to develop new lower-toxic anti-inflammatory drugs. Place and Duration of Study

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A Chawla, Pooja, Anika, Rimpi Arora, and Sharma Arvind Virendra. "Mechanistic study on the possible role of embelin in treating neurodegenerative disorders." CNS & Neurological Disorders - Drug Targets 22 (January 19, 2023). http://dx.doi.org/10.2174/1871527322666230119100053.

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Abstract: Embelin (EMB) (2,5-Dihydroxy-3-undecyl-1,4-benzoquinone) is a natural benzoquinone extracted mainly from Embelia ribes (ER) and appear as vivid orange dots beneath the fruit's pericarp. It is being used to treat various diseases since ancient times in India. It has been ascribed as one of the 32 ayurvedic drugs of national importance in the National Medicinal Plant Board set up by the Government of India under the Ministry of Indian System of Medicine and Homeopathy. Embelin prevents neuronal oxidative damage by decreasing the peroxidation of lipids. Along with having antioxidant pro

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Eiman, Fatima G. A. Miana* and Madiha Kanwal. "PHYTOCHEMICAL INVESTIGATION AND ANTIEPELEPTIC ACTIVITY OF ERYTHERINA SUBEROSA." o6, no. 05 (2019): 10699–705. https://doi.org/10.5281/zenodo.3228720.

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<em>This study presents the phytochemical investigation of leaf extract of the plant Erythrina suberosa and antiepileptic activity by using PTZ (pentylene tetrazole) model. Almost 50 million people around the world are suffering from chronic epileptic disorder with or without appearance of convulsions on the physique. Severe side effects results upon long term uses of synthetic antiepileptic drugs and addiction obligations as well. Thus, the researchers around the globe are searching for different natural resources. Erythrina suberosa is a traditional medicinal plant used to treat seizures. Ph

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Gautam, Surendra K., Sujeet K. Gupta, and Bhumika Yogi. "Synthesis and Anticonvulsant activity of new 5-((1-(2-(4-substituted phenacyl bromide)-2-oxoethyl)-2-phenyl-1H-indol-3yl) methylene) pyrimidine-2, 4, 6(1H, 3H, 5H)-trione Derivatives." Research Journal of Pharmacy and Technology, May 26, 2021, 2681–85. http://dx.doi.org/10.52711/0974-360x.2021.00473.

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In the current scenario we have plant to study to synthesize novel indole derivatives (4a-d) and (5a-b) which have the target activity like anti-convulsion and anti microbial etc. In the primary phase, we synthesized 2-phenyl-1H-indole reacted with Phosphorus oxychloride and N, N’-dimethylformamide by using vilsmeier reagent formylation of a new compound 2-phenylindole-3-carbaldehyde (2). The 2-phenylindole-3-carbaldehyde was reacted with substituted phenacyl bromide, K2CO3 and TBAB (Tetra butyl ammonium bromide) into the presence of N, N’-dimethylformamide to gives [1-(2-(4-substituted phenac

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Muhammad, Irfan Muhammad Adnan Usman Hafeez Moazzam Hussain. "TO DETERMINE THE SAFETY OF ANTI-EPILEPTIC DRUGS IN CHILDREN TREATED FOR SEIZURES." June 27, 2020. https://doi.org/10.5281/zenodo.3911225.

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<em>Epilepsy is a neurological disorder in which recurring seizures occur in the person. It is most common childhood disorder in United State. The seizures in a children start with the changes in electrical as well as chemical changes in the brain. There are various types of seizures such as absence seizures, atonic seizures, myoclonic seizures, febrile seizures and tonic-clonic seizures. Age is major factor to determine the recurrence of seizures and types of seizures. The sign and symptoms of epilepsy are convulsion with no fever, anger, jerking arms, sudden blinking, sudden stiffness and so

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Oyeyemi, Ifeoluwa T., Tunbi D. Ojo, and Oyetunde T. Oyeyemi. "Hoslundia opposita Vahl. – A Promising Source of Bioactive Compounds against Infectious and Non-infectious Diseases." Current Traditional Medicine 08 (September 21, 2022). http://dx.doi.org/10.2174/2215083808666220921163011.

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Abstract: Hoslundia opposita is an aromatic plant of the family Lamiaceae and the only member of the Hoslundia genus. It is traditionally for the treatment of HIV/AIDs related diseases, Breast cancer, Gonorrhea, Syphilis, Appendicitis, Epilepsy and convulsion, Malaria e.t.c. A review of relevant literature on biology, folkloric uses, phytochemistry and pharmacology were done. The electronic databases searched included Google Scholar, PubMed, Science Direct, Wiley and Springer. Sixteen bioactive compounds have been isolated from the plants namely; 3-O-benzoylhosloppone, 3-O-cinnamoylhosloppone,

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Duan, Jun, Jiao Wang, Qian Zhao, Dean Wu, and Yang Liu. "Anti-convulsant Effects of Scutellarein in a PTZ Kindling Model in Mice." Pharmacognosy Magazine, December 4, 2023. http://dx.doi.org/10.1177/09731296231203790.

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Background: Epilepsy is a chronic neurological condition with various underlying mechanisms. It is known to affect a multitude of people across the globe, regardless of age and gender. Seizures associated with epilepsy involve the participation of stimulatory glutamatergic mechanisms along with inflammation and oxidative damage. Objectives: In this investigation, the anti-epileptic effect of scutellarein, a phytochemical compound isolated from Erigeron breviscapus (Vant.), has been evaluated in the pentylenetetrazol (PTZ) kindling epilepsy model in mice. Materials and Methods: The experimental

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