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1

Mehr Musani, Muhammad Wasim, Hassan Salman Siddiqi, Saara Muddasir, and Fazal Manzoor Arain. "Herbal extracts: the future treatment option for drug-resistant epilepsy." Journal of the Pakistan Medical Association 73, no. 6 (2023): 1266–71. http://dx.doi.org/10.47391/jpma.7081.

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Epilepsy is a neurological disorder characterised by two or more unprovoked seizures. The high prevalence and incidence of epilepsy globally, especially in Asia, has remained a big concern over the course of centuries. Patients are usually prescribed the already known anti-epileptic drugs, but even after going through three different generations of anti-epileptic drugs, some people still suffer from drug-resistant form of epilepsy. These patients are usually prescribed a higher dose of anti-epileptic drugs, which results in more adverse effects. That is why new treatment options, like herbal e
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Gayatri, NA, and JH Livingston. "Aggravation of epilepsy by anti-epileptic drugs." Developmental Medicine & Child Neurology 48, no. 5 (2006): 394–98. http://dx.doi.org/10.1017/s0012162206000843.

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Rangarajan, Punitha, Kulandaiammal Moorthy, and Arunan Subbiah. "Observational study on the utilization pattern of adjuvant anti-epileptics and their adverse effects." International Journal of Basic & Clinical Pharmacology 9, no. 1 (2019): 170. http://dx.doi.org/10.18203/2319-2003.ijbcp20195781.

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Background: Epilepsy is a disease characterized by an enduring predisposition to generate epileptic seizures. Pharmacological therapy is the cornerstone of treatment of epilepsy. In more than 50% patients seizure not controlled with first-line anti-epileptic drugs so added with adjuvant drugs. Therefore adjuvant anti-epileptic drugs play an important role in preventing seizure remission in known epilepsy patients. Observational study was to evaluate the utilisation pattern of adjuvant anti-epileptic drugs and to assess their clinical correlation and observe the adverse effects of the adjuvant
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Maden, Buse Nur, and Saliha Ece Acuner. "Investigation of anti-inflammatory drug usage in the treatment of epilepsy through analyzing the epilepsy-inflammation relation at the molecular level." Biotech Studies 34, SI (2025): 9–24. https://doi.org/10.38042/biotechstudies.1662530.

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Epilepsy is a neurological brain disorder that affects social life by causing seizures, loss of consciousness, and muscle contractions. The causes of epilepsy include tumors, genetic diseases, brain injuries during childbirth, and infections affecting the body. Antiepileptic drugs are commonly used for treatment, but about one-third of individuals continue to experience seizures despite medication. These drugs effectively prevent seizures but do not address the underlying mechanisms of the disease. Inflammation, i.e. biological response of the body's immune system to harmful stimuli, can be th
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Zaib-un-nissa*, Muhammad Iqbal Suhail Ahmed Almani Aatir H. Rajput Muhammad Muneeb Hamid Memon Syed Jehangir and Shahrukh Shaikh. "CASUAL COMPARATIVE ANALYSIS OF GINGIVAL INDEX SCORE AMONG EPILEPTIC PATIENTS USING CARBAMAZEPINE, SODIUM VALPROATE AND PHENYTOIN." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1565–69. https://doi.org/10.5281/zenodo.817621.

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Abstract: Objective: This research hoped to compare the periodontal health of epileptic patients using three different anti-epilepsy drugs, namely, carbamazepine, phenytoin and sodium valproateusing the gingival index score. Methodology: This casual comparative analysis of periodontal health was conducted at Liaquat University Hospital from January to March (2017) upon 3 groups of patients, each using a different anti-epileptic drug. The groups comprised of 15 patients each and the groups were matched for age, sex and duration of drug therapy. All recordings made on the gingival index score on
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Tri Utami, Melinda, Refani Adisti Rahmadini, Adelia Putri, et al. "REVIEW ARTIKEL : PENGGUNAAN OBAT ANTI EPILEPSI DI RUMAH SAKIT." Medimuh : Jurnal Kesehatan Muhammadiyah 4, no. 2 (2023): 113–18. http://dx.doi.org/10.37874/mh.v4i2.632.

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ABSTRAK 
 Epilepsi adalah gangguan pada sistem saraf pusat akibat pola aktivitas listrik yang berlebihan di otak (Rahmat, 2021). Epilepsi memerlukan pengobatan yang lama (Dewi, 2020). Kepatuhan minum obat akan mempengaruhi hasil pengobatan. Hal ini menyebabkan penderitanya mengalami kejang secara berulang pada sebagian atau seluruh tubuh. Tujuan penelitian ini untuk mengetahui penggunaan obat antiepilepsi di Rumah Sakit dan untuk mengetahui beberapaorang yang menderita epilepsi di berbagai kota di Indonesia. Metode penelitian yang digunakan dalam artikel ini dengan mengumpulan jumlah pene
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Lv, Yu-Qin, Xing Wang, Yu-Zhuang Jiao, et al. "Interactome overlap between risk genes of epilepsy and targets of anti-epileptic drugs." PLOS ONE 17, no. 8 (2022): e0272428. http://dx.doi.org/10.1371/journal.pone.0272428.

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Aanti-epileptic drugs have been used for treating epilepsy for decades, meanwhile, more than one hundred genes have been identified to be associated with risk of epilepsy; however, the interaction mechanism between anti-epileptic drugs and risk genes of epilepsy was still not clearly understood. In this study, we systematically explored the interaction of epilepsy risk genes and anti-epileptic drug targets through a network-based approach. Our results revealed that anti-epileptic drug targets were significantly over-represented in risk genes of epilepsy with 17 overlapping genes and P-value =
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8

Bharat, Sharma, and Sakshi Parul. "Interactions Between Anti-Epileptic Drugs and Contraceptives: A Review." International Healthcare Research Journal 5, no. 1 (2021): RV14—RV18. https://doi.org/10.26440/IHRJ/0501.04409.

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Around half of the pregnancies in women with epilepsy are unplanned and the choice of contraceptive method in epileptic women is important, since it requires considering their possible pharmacological interactions with certain types of anti-epileptic drugs. Drugs from this class which induce hepatic enzyme activity may alter the metabolism of most hormonal methods of contraception, and this may affect their contraceptive efficacy. Hormonal contraception is regarded as highly effective, but its interaction with anti-epileptics may accelerate the metabolism of the latter with the consequent risk
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9

Kulshreshtha, Dinkar, Pradeep Maurya, Ajai Singh, and Anup Thacker. "Withdrawal of anti-epileptic drugs: A review." International Journal of Epilepsy 02, no. 01 (2015): 038–43. http://dx.doi.org/10.1016/j.ijep.2015.03.002.

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AbstractAnti-epileptic drugs are the mainstay in treatment of epilepsy. It requires a strong clinical decision in patients who are well controlled on medications to withdraw anti-epileptic drugs. This decision has to be based on the clinical profile, epilepsy type, neuroimaging and electroencephalography (EEG) findings and has to be more individualized as per the patient needs. In the context of drug withdrawal, it is necessary to look into the details of why, how and when to withdraw anti-epileptics. In this article, we critically try to answer such queries and look into the established guide
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10

Muralinath, E., Devi Pooja, Chbukdhara Prasanta, et al. "The Complex Relationship between Drugs and Epileptic Patients: A Comprehensive Exploration." Journal of Trauma, Orthopaedic and Urological Nursing 2, no. 1 (2023): 7–10. https://doi.org/10.5281/zenodo.10416835.

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<em>Epilepsy is a neurological disorder manifested by recurrent seizures, influencing millions of people worldwide. Anti-epileptic drugs (AEDs) are treated as primary treatment for epilepsy. Anti-epileptic drugs show their action on various targets particularly within the brain, namely ion channels, neurological transmitter system. Types of Anti-epileptic drugs include calcium channel blockers, GABA enhancers, glutamate receptor antagonist and sodium channel blockers. Side effects of AEDs are dizziness or drowsiness, life style factors namely sleep, stress management. Some studies indicate tha
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Mutanana, Ngonidzashe. "Challenges Associated with Anti-epilepsy Medication and Use of Complementary or Alternative Medicines among People with Epilepsy in Rural Communities of Zimbabwe." Malaysian Journal of Medical and Biological Research 6, no. 2 (2019): 77–84. http://dx.doi.org/10.18034/mjmbr.v6i2.475.

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The main objective of this study was to analyze challenges associated with anti-epilepsy medication and use of complementary or alternative medicines among people with epilepsy in rural communities of Zimbabwe. The study opted for qualitative research because it is culturally specific and data collected is contextually rich. The target population was people with epilepsy and caregivers of children with epilepsy and using a snowball sampling technique, a sample of 15 people with epilepsy and 5 caregivers of children with epilepsy was selected. The study purposively selected 2 traditional healer
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Miziak, Barbara, Agnieszka Konarzewska, Marzena Ułamek-Kozioł, Monika Dudra-Jastrzębska, Ryszard Pluta, and Stanisław J. Czuczwar. "Anti-Epileptogenic Effects of Antiepileptic Drugs." International Journal of Molecular Sciences 21, no. 7 (2020): 2340. http://dx.doi.org/10.3390/ijms21072340.

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Generally, the prevalence of epilepsy does not exceed 0.9% of the population and approximately 70% of epilepsy patients may be adequately controlled with antiepileptic drugs (AEDs). Moreover, status epilepticus (SE) or even a single seizure may produce neurodegeneration within the brain and SE has been recognized as one of acute brain insults leading to acquired epilepsy via the process of epileptogenesis. Two questions thus arise: (1) Are AEDs able to inhibit SE-induced neurodegeneration? and (2) if so, can a probable neuroprotective potential of particular AEDs stop epileptogenesis? An affir
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13

Kotov, A. S., and K. V. Firsov. "Epilepsy and Hyperthermia: a Review." Comorbidity neurology 2, no. 1 (2025): 13–19. https://doi.org/10.62505/3034-185x-2025-2-1-13-19.

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INTRODUCTION. Viral and bacterial infections accompanied by a rise in temperature (hyperthermia) are among the most common (if not the most common) diseases in the world. These conditions may pose an additional danger to patients with epilepsy, who may experience an increase in seizures during fever. The purpose of this review is to familiarize colleagues with the risk factors for seizures, as well as the nuances of using various classes of drugs in patients with "common" infections accompanied by hyperthermia and comorbid epilepsy. AIM. To identify the features of the interaction between epil
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14

Mawuntu, Arthur H. P., Herlyani Khosama, Corry N. Mahama, Sekplin A. S. Sekeon, and Karema Winifred. "Anti-epileptic drugs adherence of epilepsy patients in Indonesia." International Journal Of Community Medicine And Public Health 7, no. 6 (2020): 2082. http://dx.doi.org/10.18203/2394-6040.ijcmph20202456.

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Background: Adherence to medication is an important component of successful epilepsy treatment. However, the disease’s long-term treatment makes it difficult to achieve good adherence. This study aimed to assess the adherence level of anti-epileptic drugs (AEDs) among adult epilepsy patients in Indonesia and its associated factors.Methods: We reviewed the medical records of epilepsy patients in a tertiary public hospital between September 2018 and August 2019. Subjects were patients who were electro-clinically diagnosed with any type of epilepsy, have been taken at least one AED for at least t
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Aref, Diyar, Amanda Armstrong, Rosul Gulam, and Sanarya Namuq. "Prescribing for established adult patients with epilepsy." Journal of Prescribing Practice 1, no. 11 (2019): 566–69. http://dx.doi.org/10.12968/jprp.2019.1.11.566.

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This article examines prescribing for patients who have epilepsy and are on anti-epilepsy medication. It highlights the need to be vigilant when prescribing for patients with epilepsy, and be aware of the risks of any medication that you are prescribing and the impact it could have on the patient's epilepsy. The articles establishes that some patients are on anti-epilepsy drugs for indications other than epilepsy and therefore it is important to take a good medical and drug history before prescribing. When prescribing repeat anti-epilepsy medication for established patients, who are already un
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Yadav, BK, and L. Sharma. "Initial management of epilepsy." Journal of General Practice and Emergency Medicine of Nepal 1, no. 1 (2010): 41–45. http://dx.doi.org/10.59284/jgpeman200.

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There is no sufficient evidence to prove one anti epileptic drug to be superior to another, so selection of antiepileptic drugs should be individualized according to the patient. Monotherapy should be the goal when anti epileptic drug treatment is instituted for epilepsy.
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Mishra, Ashish, Jeetendra Kumar Gupta, Nilesh Jain, and Sunil Mistry. "Preliminary evaluation of melatonin in the kindling model of epilepsy." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 223–26. http://dx.doi.org/10.22270/jddt.v9i2-s.2496.

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During the past decades, epilepsy syndrome has been depicted across India as well as worldwide and this leads to increasing mortality and morbidity rate. Researchers are trying to investigate the responsible causes and risk factors for seizure occurrence. Epilepsy is a chronic disorder which is derived from a Latin word ‘sacire’ meaning ‘convulsive attack’ and is expressed as a paroxysmal experience appointed to atypical, unnecessary or concurrent neuronal bustle in the brain. The treatment of epilepsy involves the use of anti-epileptic drugs i.e. Sodium valproate, phenytoin, carbamazepine. De
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Absar Neyan A, Ajans Samuel J, Amirtha Varshini M K M, and Mohan Kumar M. "Factors influencing withdrawal of anti-epileptic drugs and management of recurrent seizure: A systematic review." International Journal of Science and Research Archive 13, no. 1 (2024): 419–25. http://dx.doi.org/10.30574/ijsra.2024.13.1.1658.

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Objective: This study aims to investigate the risk factors associated with seizure recurrence following the withdrawal of antiepileptic drugs (AEDs) in patients with epilepsy. Method: A systemic review of recent literature and clinical studies was conducted, focusing on variables such as patient demographics, epilepsy characteristics, treatment history, comorbid condition, adherence to treatment, withdrawal protocols and seizure outcomes were included. Results: factors like polypharmacy AED drugs, undesirable effects, cognitive impairment, cost, compliance are leads to withdrawal of antiepilep
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Chintalapati, Janaki, Arvind Kumar, MV Hosur, and Supriya N. Pal. "TREADS: Target Research for Anti-epileptic Drugs Using Data Science." Neurology India 72, no. 3 (2024): 620–25. http://dx.doi.org/10.4103/neuroindia.ni_261_21.

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Context: Epilepsy is a common neurological disease and is classified into different types based on features such as the kind of seizure, age of onset, part of brain effected, etc. There are nearly 30 approved anti-epileptic drugs (AEDs) for treating different epilepsies and each drug targets proteins exhibiting a specific molecular mechanism of action. There are many genes, proteins, and microRNAs known to be associated with different epileptic disorders. This rich information on epilepsy-associated data is not available at one single location and is scattered across multiple publicly availabl
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Boshuisen, K., O. Braams, A. Jennekens-Schinkel, P. van Rijen, and O. van Nieuwenhuizen. "ETO04 Anti-epileptic drugs after epilepsy surgery in children." European Journal of Paediatric Neurology 11 (September 2007): 40–41. http://dx.doi.org/10.1016/s1090-3798(08)70395-7.

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Vezzani, Annamaria. "Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis?" Expert Opinion on Drug Safety 14, no. 4 (2015): 583–92. http://dx.doi.org/10.1517/14740338.2015.1010508.

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Radu, Beatrice Mihaela, Florin Bogdan Epureanu, Mihai Radu, Paolo Francesco Fabene, and Giuseppe Bertini. "Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy." Epilepsy Research 131 (March 2017): 15–27. http://dx.doi.org/10.1016/j.eplepsyres.2017.02.003.

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Gude, Dilip. "Epilepsy, anti-epileptic drugs and bone health in children." Journal of Pediatric Neurosciences 6, no. 1 (2011): 93. http://dx.doi.org/10.4103/1817-1745.84425.

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Skovola, Eleftheria, Giunio Bruto Cherubini, and Sara Ferrini. "Alternative drugs to phenobarbital in canine epileptic patients." Companion Animal 26, no. 5 (2021): 1–11. http://dx.doi.org/10.12968/coan.2020.0076.

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Epilepsy is one of the most common chronic neurological diseases in companion animals. The first choice for anti-epileptic drugs has consistently been phenobarbital. However, the presence of side effects or contraindications for its use, or poor control of seizures in some canine patients, may require the replacement of phenobarbital, or the addition of more anti-epileptic drugs to the treatment protocol. This article describes the indications, mechanism of action, pharmacokinetics, recommended doses and adverse effects of anti-epileptic drugs whic can be used in place of phenobarbital. A revi
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Anwar, T. T. Muhammed, P. P. Muhamed Faris, and ,. Thansiha. "A Systematic Review on Lamotrigine Induced Skin Rashes." Journal of Drug Delivery and Therapeutics 11, no. 1 (2021): 146–51. http://dx.doi.org/10.22270/jddt.v11i1.4633.

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Lamotrigine is a newer anti-epileptic drug synthesised in 1980s and approved by USFDA in 1994. It is mainly used for treating paediatric epilepsy and one of the frequently prescribing newer anti- epileptic drugs in European countries. In English scenario, lamotrigine is suggested as monotherapy for recently identified partial seizures (localized seizure) in children as its first line drug. Lamotrigine is recommended for generalized seizures as second line drug and as add on therapy in intractable generalized epilepsy. It is a treatment option after sodium valproate and ethosuximide for petit-m
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Weaver, Donald F. "Epileptogenesis, Ictogenesis and the Design of Future Antiepileptic Drugs." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 30, no. 1 (2003): 4–7. http://dx.doi.org/10.1017/s0317167100002353.

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ABSTRACT:There is still no medical cure for epilepsy. Clinical epileptology is in need of a “paradigm shift” when it comes to the continuing development of therapeutics. An important first step in this conceptual evolution is differentiating between the notions of ictogenesis and epileptogenesis. All traditional therapeutics are anti-ictogenic, not antiepileptogenic. The future of antiepileptic drug development lies in the discovery of antiepileptogenics. Just as aspirin is not the drug of choice for meningitis, an anticonvulsant is not the drug of choice for epilepsy. Drug design for epilepsy
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Lebedeva, A. V., S. G. Burd, P. N. Vlasov, et al. "Treatment of epilepsy associated with primary and metastatic brain tumors." Epilepsy and paroxysmal conditions 13, no. 3 (2021): 286–304. http://dx.doi.org/10.17749/2077-8333/epi.par.con.2021.099.

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There is a number of unsolved issues in management of epilepsy associated with primary and metastatic brain tumors (BTs). In particular, no consensus approaches to treatment of patients with epilepsy associated with BTs have been proposed regarding use of current anti-epileptic drugs (AEDs). The review presents the relevant data on epidemiology, features of clinically manifested epilepsy at varying stages of BTs, aspects of drug-drug interaction between AEDs and anti-tumor agents, AED-related effects on cognitive functions as well as quality of life in patients with epilepsy associated with BT
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Narwat, Arvind, and Vivek Sharma. "Prescription pattern of antiepileptic drugs in indoor patients at tertiary care hospital in Haryana, India." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 537. http://dx.doi.org/10.18203/2319-2003.ijbcp20180670.

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Background: Epilepsy is a challenging medical problem in India with an annual incidence of 27.27 per 100,000 population and prevalence of 572.8 per 100,000. People with epilepsy require prolonged treatment and monitoring. The main goal in the treatment of epilepsy should be adequate control of seizures, without causing any life-threatening reactions due to the medications. This study was done to get an insight into the prescription pattern of anti-epileptic drugs (AEDs) in different types of epilepsy.Methods: A prospective study was carried out for six months (Feb to June 2016) in admitted pat
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Opiyo, Sylvia Awino. "Herbal Extracts Exhibit Anti-Epilepsy Properties." IOSR Journal of Applied Chemistry 17, no. 11 (2024): 09–23. http://dx.doi.org/10.9790/5736-1711010923.

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Epilepsy refers to a group of persistent neurological illnesses characterized by seizures. It is a chronic brain disease that affects 50 million people in the world, being one of the most common neurological disorders. Developing countries account for over 90% of all epilepsy patients. Epileptic seizures are caused by aberrant, excessive, or hyper synchronized neuronal activity in the brain. The cause of most epileptic seizures is unknown. However, some people develop epilepsy as a result of a brain injury, stroke, brain tumor, or drug and alcohol abuse. Anti-seizure drugs remain the mainstay
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Lee, Seung Cheol, Hyeon Don Hong, Hyun Kyo Lim, and Seung Woo Song. "Total intravenous anesthesia with remimazolam in a patient with epilepsy who underwent deep brain stimulation: a case report." Journal of the Korean Society of Stereotactic and Functional Neurosurgery 18, no. 2 (2022): 103–6. http://dx.doi.org/10.52662/jksfn.2022.00241.

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Drugs administered for anesthesia can trigger seizure attacks in patients with epilepsy. Benzodiazepines have been consistently reported to be anticonvulsants, and a novel benzodiazepine, remimazolam, was recently introduced. We report a case of total intravenous anesthesia maintained with remimazolam in a patient with epilepsy who underwent deep brain stimulation of both anterior thalamic nuclei. Despite the administration of multiple anti-epileptic drugs, no tolerance to remimazolam was observed. Perioperative seizures were also not observed. Remimazolam can be considered the anesthetic of c
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Abd El Dayem, Soha M., Osama N. Saleh, Nahed A. Emara, Manal E. Kandil, Rania H. Shatla, and Sara Elgammal. "Evaluation of Homocysteine, Folic Acid and Vitamin B12 Levels among Egyptian Children with Idiopathic Epilepsy." Open Access Macedonian Journal of Medical Sciences 2, no. 1 (2014): 109–13. http://dx.doi.org/10.3889/oamjms.2014.019.

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Objective: To evaluate relationship between homocysteine (Hcy), folic acid and vitamin B12 with anti-epileptic drugs in epileptic patients and their role in epilepsy control.Patient and Methods: The study included 60 patients with idiopathic epilepsy and thirty non-epileptic children of the same age and sex served as controls. All cases were subjected to physical and neurological examination and electroencephalogram (EEG). Serum level of folic acid, homocysteine (Hcy) and vitamin B12 were done for both epileptic patients and controls. Non parametric test, one way ANOVA and Pearson’s correlatio
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Saraswati, Putu Dewinadya. "Characteristics of Epilepsy Outpatients Sufferer at Bali Mandara Hospital in January - December 2019." E-Jurnal Medika Udayana 11, no. 1 (2022): 25. http://dx.doi.org/10.24843/mu.2022.v11.i01.p05.

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Background: Epilepsy is one of the chronic neurologic disease that often found the cases. Epilepsy is a global health issue that affected 50 million people around the world Objective: This study aims to determine the characteristics of epilepsy outpatients in Bali Mandara Regional Hospital in January-December 2019. Method: The method used in this study was a cross sectional descriptive study using secondary data of patient medical records. Obtained data that met the inclusion criteria was 149. Data analyzed by using SPSS 20 program. Results: The most frequent age category is 0-17 years about 5
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Wang, Wei. "Advance on synthesis, pharmacokinetics, and pharmacodynamics of the anti-epileptic drug: Levetiracetam." E3S Web of Conferences 185 (2020): 03006. http://dx.doi.org/10.1051/e3sconf/202018503006.

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Over the past few decades, many patients around the world have suffered from epilepsy, and epilepsy treatment is a long-term process. Thus, the safety and efficacy of medication for epilepsy are of equal importance. Levetiracetam is a second-generation anti-epileptic drug with a unique mechanism of action, good anti-epileptic efficacy, and safety. The therapeutic field has broad application prospects because levetiracetam offers several advantages over other anti-epileptic drugs. In this review, the synthesis, pharmacokinetics, pharmacodynamics, and reverse reaction of levetiracetam were summa
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Nanoti, Girish, Shantanu Shembalkar, and Prafulla Shembalkar. "Use of Paediatric Epilepsy Side Effects Questionnaire (PESQ) for Early Detection of Adverse Effects of Anti-Epileptic Drugs in Children with Epilepsy." Indian Journal of Trauma and Emergency Pediatrics 8, no. 2 (2016): 85–94. http://dx.doi.org/10.21088/ijtep.2348.9987.8216.8.

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Suwasanti, Niluh, Aryati Aryati, Darto Saharso, and Ferdy Royland Marpaung. "CORRELATION OF VITAMIN D AND CALCIUM LEVELS IN CHILDREN IN NEW DIAGNOSED EPILEPSY AND MINIMAL 6 MONTHS AFTER THERAPY." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 46. http://dx.doi.org/10.24293/ijcpml.v26i1.1348.

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INTRODUCTION. Children with epilepsy should take long-term anti-epileptic drugs. Long-term use of anti-epileptic drugs can reduce vitamin D levels. Low vitamin D will lead to low blood calcium levels. This study aims to analyze the relationship between vitamin D and calcium levels in newly diagnosed epileptic children and ≥6 months after therapy. METHOD. These was an analytical observational study with cross sectional research design. The vitamin D examination instrument uses the ELFA method (enzyme linked fluorescent assay) with the Vidas instrument from bioMerieux. Samples were collected dur
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Silvestro, Serena, Santa Mammana, Eugenio Cavalli, Placido Bramanti, and Emanuela Mazzon. "Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials." Molecules 24, no. 8 (2019): 1459. http://dx.doi.org/10.3390/molecules24081459.

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Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of re
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Delen, Dursun, Behrooz Davazdahemami, Enes Eryarsoy, Leman Tomak, and Abhinav Valluru. "Using predictive analytics to identify drug-resistant epilepsy patients." Health Informatics Journal 26, no. 1 (2019): 449–60. http://dx.doi.org/10.1177/1460458219833120.

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Epilepsy is one of the most common brain disorders that greatly affects patients’ quality of life and poses serious risks to their health. While the majority of the patients positively respond to the existing anti-epilepsy drugs, others who developed the refractory type of epilepsy show resistance against drug therapy and need to undergo advance treatments such as surgery. Given that identifying such patients is not a straightforward process and requires long courses of trial and error with anti-epilepsy drugs, this study aims at predicting those at-risk patients using clinical and demographic
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Machmoed, Hadia Anggriani, Nadya A. R. Bubakar, Urfianty Urfianty, and Idham Jaya Ganda. "CORRELATION BETWEEN THE DURATION OF ANTI-EPILEPTIC DRUGS THERAPY AND VITAMIN D LEVEL IN EPILEPTIC CHILDREN." International Journal of Health Science & Medical Research 2, no. 1 (2022): 1–10. http://dx.doi.org/10.37905/ijhsmr.v2i1.14286.

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Long-term use of antiepileptic drugs (AEDs) for epilepsy causes a decrease in vitamin D levels due to the activation of liver cytochrome P450 enzymes. The novelty of this study is due to researching about correlation between the duration of anti-epileptic drugs therapy and vitamin d level in epileptic children This cross-sectional study was conducted from October - December 2021in children with epilepsy aged 1 month to 18 years admitted to pediatric neurology polyclinic of DR Wahidin Sudirohusodo. They were divided into two groups: epileptic children receiving AEDs treatment ≤ 1 year and epi
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Francois, Xavier Ndayambaje, Natukunda Bernard, and Bosco Gahutu Jean. "Prevalence of Metabolic Syndrome amongst Rwandan Patients with Epilepsy." Pharmaceutical and Chemical Journal 7, no. 4 (2020): 43–52. https://doi.org/10.5281/zenodo.13955239.

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Cardiovascular mortality and morbidity are more frequent in people with epilepsy than in general population. The explanation of that may be the change in biochemical components due to anti-epileptic drugs. We conducted this study to determine the prevalence of metabolic syndrome (MetS) and risk factors in adults with epilepsy emphasizing on respective anti-epileptic drugs patients were using. <strong><em>Method:</em></strong> This was a cross-sectional study conducted from December 2018 to December 2019 in patients with epilepsy aged 18-60 years old who were on anti-epileptic drugs for at leas
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Kotov, A. S., and K. V. Firsov. "Epilepsy in mitochondrial diseases. Clinical lecture." Russian Journal of Child Neurology 17, no. 4 (2023): 63–70. http://dx.doi.org/10.17650/2073-8803-2022-17-4-63-70.

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Mitochondrial dysfunction mainly affects organs with high metabolic demand, primarily the brain. Epilepsy is a common phenotypic sign of both syndromic and non-syndromic mitochondrial diseases. Epilepsy in mitochondrial diseases is poorly treatable and is often an unfavorable prognostic sign. Patients with mitochondrial epilepsy are prescribed various anti-seizure medications. Mitochondriotoxic drugs should be avoided. Descriptions of MELAS-syndrome, MERRF-syndrome, Leigh-syndrome, NARP-syndrome are given.
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Packer, R. M. A., N. K. Shihab, B. B. J. Torres, and H. A. Volk. "Responses to successive anti-epileptic drugs in canine idiopathic epilepsy." Veterinary Record 176, no. 8 (2015): 203. http://dx.doi.org/10.1136/vr.102934.

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Łukasiuk, Katarzyna, and Władysław Lasoń. "Emerging Molecular Targets for Anti-Epileptogenic and Epilepsy Modifying Drugs." International Journal of Molecular Sciences 24, no. 3 (2023): 2928. http://dx.doi.org/10.3390/ijms24032928.

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The pharmacological treatment of epilepsy is purely symptomatic. Despite many decades of intensive research, causal treatment of this common neurologic disorder is still unavailable. Nevertheless, it is expected that advances in modern neuroscience and molecular biology tools, as well as improved animal models may accelerate designing antiepileptogenic and epilepsy-modifying drugs. Epileptogenesis triggers a vast array of genomic, epigenomic and transcriptomic changes, which ultimately lead to morphological and functional transformation of specific neuronal circuits resulting in the occurrence
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Madireddy, Sahithi, and Samskruthi Madireddy. "Therapeutic Strategies to Ameliorate Neuronal Damage in Epilepsy by Regulating Oxidative Stress, Mitochondrial Dysfunction, and Neuroinflammation." Brain Sciences 13, no. 5 (2023): 784. http://dx.doi.org/10.3390/brainsci13050784.

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Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures that affects 50 million individuals globally. Because approximately one-third of patients with epilepsy do not respond to drug therapy, the development of new therapeutic strategies against epilepsy could be beneficial. Oxidative stress and mitochondrial dysfunction are frequently observed in epilepsy. Additionally, neuroinflammation is increasingly understood to contribute to the pathogenesis of epilepsy. Mitochondrial dysfunction is also recognized for its contributions to neuronal excitability and apo
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Bhardwaj, Ankit, Anand Shukla, Sunita Singh, and Anil Kem. "Cyproheptadine adverse drug interaction with anti-epileptic drugs." International Journal of Basic & Clinical Pharmacology 7, no. 3 (2018): 577. http://dx.doi.org/10.18203/2319-2003.ijbcp20180677.

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Cyproheptadine is a H1 and 5- HT1/2 receptor antagonists, impairing the anticonvulsant activity of antiepileptic drugs and reduces threshold, increases severity of seizures, when administered chronically. Anuj a 13 years old male from Delhi, known case of SSPE stage-III with epilepsy, on oral anti-epileptic drug has seizure induction followed the use of oral cyproheptadine. Stopping cyproheptadine, patient didn’t sustain any further seizures.
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Zhang, Liang, Hao Yu, Dan Li, Hui Qian, and Yuchao Chen. "Spermatorrhea in a Chinese patient with temporal lobe epilepsy: a case report." Journal of International Medical Research 49, no. 1 (2021): 030006052098281. http://dx.doi.org/10.1177/0300060520982814.

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Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure. Sexual dysfunction has been reported in patients with seizure, which mostly manifests as erectile dysfunction and premature ejaculation in men. In this study, we report the case of a 65-year-old Chinese man with frequent spermatorrhea. Electroencephalography suggested local epilepsy in the left temporal lobe. After treatment with anti-epilepsy drugs, the symptoms disappeared and did not recur. To the best of our knowledge, this is the first reported case of epilepsy-induced spermatorrhea. The symptoms of
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S, Manjula, and Krishna Kumar M. "Expert Opinion on the Prescription Practice of Levetiracetam for Different Types of Epilepsy in Indian Clinical Settings." SAR Journal of Psychiatry and Neuroscience 5, no. 01 (2024): 1–6. http://dx.doi.org/10.36346/sarjpn.2024.v05i01.001.

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Despite some studies assessing antiepileptic drug usage patterns in single-centre settings, there was a lack of consensus regarding usage patterns, drug choices for various seizure types, and the sociodemographic and clinical factors that influence treatment decisions in India. So, this current survey-based study was intended to gather expert opinions regarding the clinical use of anti-epileptic drugs with a special focus on levetiracetam for the management of epilepsy in Indian settings. A questionnaire-based cross-sectional study involving 25 questions collected perspectives of experts acros
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Cen, Xinyu. "Advances in Drug Treatment of Refractory Epilepsy." Theoretical and Natural Science 70, no. 1 (2024): 97–103. https://doi.org/10.54254/2753-8818/2024.18243.

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Refractory epilepsy is a nervous system disease that does not respond well to conventional anti-epileptic drugs, and has always been a difficult problem to be solved in the medical field. The purpose of this paper is to comprehensively review and analyze the current progress of drug therapy for refractory epilepsy, in order to provide reference for future clinical practice and research. In this paper, the definition, classification, pathogenesis and mechanism of refractory epilepsy were summarized. Subsequently, the application and limitations of traditional antiepileptic drugs, as well as the
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Ashraf, Hamid, Lubna Zafar1, and Damera Achyut Kumar1. "Abstract 76: Alteration in bone metabolism and bone mineral density with chronic anti-epileptic drug therapy in North Indian population." Indian Journal of Endocrinology and Metabolism 26, Suppl 1 (2022): S30. http://dx.doi.org/10.4103/2230-8210.342197.

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Objective: Anti-epileptic drugs are the mainstay of treatment of epilepsy. Prolong use of anti-epileptic medicines can lead to reduction in bone mineral density (BMD), resulting in 2-6-fold increase in fracture risk. This study was carried out to assess the impact of AEDs on the markers of bone turnover and BMD in North Indian patients. Methods: In this hospital based observational study sixty adult patients with epilepsy, on antiepileptic drugs were included. Serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, 25 (OH) vitamin D and intact Parathyroid hormone (iPTH) and BMD (at lum
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Prakash, Satya, Abhijeet Kumar, Ajay Kumar, and Ambrish Kumar Singh. "A REVIEW ON EPILEPSY AND ITS MANAGEMENT." International Ayurvedic Medical Journal 13, no. 05 (2025): 1356–64. https://doi.org/10.46607/iamj1013052025.

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The most common neurological disorder of the brain in the present time is epilepsy, which affects nearly about 50 million people worldwide. Out of them, nearly 90% of patients are from developing countries. Epilepsy is a disorder which can affect every age group. Some common causes of epilepsy are genetic factors actor, infection in the brain, stroke, tumour and high fever. Every year, nearly 125,000 cases of epilepsy occur; of them, at the time of diagnosis, 30% are younger, around the age of 18. Patients who are suffering from epilepsy generally keep themselves isolated and feel insecure abo
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Halil, Halit, Nilden Tuygun, Erhan Aksoy, Ozcan Erel, and Can Demir Karacan. "Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients." Combinatorial Chemistry & High Throughput Screening 22, no. 1 (2019): 65–68. http://dx.doi.org/10.2174/1386207322666190305135043.

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Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body. Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients. Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and nati
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