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Rozprawy doktorskie na temat „Anti-Parkinson”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Hussein, Nozad Rashid. "Bioadhesive microparticles and liposomes of anti-Parkinson drugs for nasal delivery." Thesis, University of Central Lancashire, 2014. http://clok.uclan.ac.uk/9788/.

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The nasal route is highly promising for the delivery of drugs exerting local effects in the nose or for therapeutic molecules having systemic or CNS effect. This is attributed to the fact that the nasal epithelium is highly vascularized and permeable, which ensures rapid absorption of the drug. The limitation of short residence time of the formulations in the nose and poor bioavailability of hydrophilic drugs could be overcome by the inclusion of bioadhesive agents into formulation. The main objective of this study was to develop novel bioadhesive microspheres and liposomes entrapping the anti

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Kanter, Marlene. "Organisationsprinzipien der extrazellulären Matrix in der Substantia nigra des Menschen und ihr Bezug zum Morbus Parkinson." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-62572.

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Der Morbus Parkinson ist durch den selektiven Zelltod der dopaminergen Neurone der Substantia nigra pars compacta gekennzeichnet. Hierbei sind die verschiedenen Populationen pigmentierter Neurone innerhalb der SNc unterschiedlich stark betroffen. Die Ursachen für diese unterschiedliche Schädigung sind noch nicht bekannt. Möglicherweise besteht aber ein Zusammenhang mit der Verteilung der extrazellulären Matrix innerhalb der Substantia nigra. Für die Untersuchung wurden immunhistochemische Methoden an Hirnschnittserien von menschlichen Kontrollgehirnen angewandt. Zur Darstellung von Komponenten

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Nakaoka, Sachiko. "Prescribing pattern of anti-Parkinson drugs in Japan: a trend analysis from 2005 to 2010." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/193574.

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Nakaoka S, Ishizaki T, Urushihara H, Satoh T, Ikeda S, et al. (2014) Prescribing Pattern of Anti-Parkinson Drugs in Japan: A Trend Analysis from 2005 to 2010. PLoS ONE 9(6): e99021. doi:10.1371/journal.pone.0099021<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(社会健康医学)<br>甲第18649号<br>社医博第61号<br>新制||社医||8(附属図書館)<br>31563<br>京都大学大学院医学研究科社会健康医学系専攻<br>(主査)教授髙橋良輔, 教授川上浩司, 教授松原和夫<br>学位規則第4条第1項該当

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Araujo, Dayane Pessoa. "Atividade anti-inflamatória e neuroprotetora da fração de Aspidosperma pyrifolium rica em derivado glicosilado do ácido salicílico." reponame:Repositório Institucional da UFC, 2017. http://www.repositorio.ufc.br/handle/riufc/25372.

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ARAUJO, D. P. Atividade anti-inflamatória e neuroprotetora da fração de Aspidosperma pyrifolium rica em derivado glicosilado do ácido salicílico. 2017. 141 f. Tese (Doutorado em Farmacologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2017.<br>Submitted by Farmacologia Pós-Graduação (posgfarmacologia@gmail.com) on 2017-08-31T14:19:38Z No. of bitstreams: 1 2017_tese_ dparaujo.pdf: 4402876 bytes, checksum: ff7ad728ad291379acc04af1fdd28c20 (MD5)<br>Approved for entry into archive by Erika Fernandes (erikaleitefernandes@gmail.com) on 2017-08-31T16:42:03Z (GMT) No. of bitstr

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Gschmack, Eva Maria Verfasser], Carsten [Gutachter] Scheller, and Thomas [Gutachter] [Dandekar. "Anti-Gehirn-Autoantikörper und deren Bedeutung bei Morbus Parkinson / Eva Maria Gschmack ; Gutachter: Carsten Scheller, Thomas Dandekar." Würzburg : Universität Würzburg, 2017. http://d-nb.info/1147290024/34.

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El, Kodsi Daniel N. "A Redox Chemistry-based Function for Parkinson Disease-linked Parkin Confers Direct, Anti-oxidant Activities in Mammalian Brain." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41129.

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Early-onset Parkinson disease, of which the best studied and most common cause are biallelic mutations in the PRKN gene, is characterized by an age of onset before 40 years. Parkin-deficient patients show slow progression, excellent responsiveness to L-dopa therapy, and are generally spared cognitive decline. At autopsy, PRKN-linked Parkinson disease is further distinguished by relative selectivity in cell loss, namely of dopamine producing neurons in the human brainstem, and the general absence of Lewy body inclusions. Since its discovery two decades ago, the field has focused on the function

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Oliveira, Juciele Valéria Ribeiro de. "Efeito neuroprotetor da formononetina em modelo animal para estudo da doença de Parkinson." Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3267.

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This study aimed to evaluate the antioxidant activity in vitro, as well as and the possible neuroprotective effect in vivo of the isoflavonoid formononetin (FORM) in an experimental model for the study of Parkinson's disease (PD). Among the methods used to determine the antioxidant activity of FORM in vitro, they were elected the DPPH, ABTS and FRAP. In the in vivo assays, FORM was evaluated for its biological activity on experimental PD induced by 6- hydroxydopamine (6-OHDA, 10 μg in 2 μL) injection in the right striatum. Control groups received saline containing 0.02% of ascorbic acid

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Blaudin, de Thé Francois-Xavier. "Engrailed, an anti-ageing homeoprotein." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066204/document.

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Les homéoprotéines sont des facteurs de transcription morphogénétiques qui ont des fonctions cellulaire et non cellulaire-autonomes. Par exemple, En1 et En2 (Engrailed/En) sont importants pour le développement des neurones dopaminergiques du mésencéphale (mDA) et cruciaux pour leur maintien chez l'adulte. Les souris En1+/- présentent une dégénération progressive et spécifique des neurones mDA de la Substantia Nigra pars compacta (SNpc), rappelant la maladie de Parkinson. De plus, l'infusion d'En dans plusieurs modèles de la maladie sauve ces neurones. Dans le modèle MPTP, cela passe par l'augm

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Pinto, Natália Bitú. "Avaliação da atividade neuroprotetora do extrato padronizado de Camellia sinensis e de seus princípios bioativos: envolvimento de ações anti-inflamatórias e antioxidantes." reponame:Repositório Institucional da UFC, 2015. http://www.repositorio.ufc.br/handle/riufc/13906.

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PINTO, N. B. Avaliação da atividade neuroprotetora do extrato padronizado de Camellia sinensis e de seus princípios bioativos: envolvimento de ações anti-inflamatórias e antioxidantes. 2015. 296 f. Tese (Doutorado em Farmacologia) - Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, 2015.<br>Submitted by Erika Fernandes (erikaleitefernandes@gmail.com) on 2015-11-05T14:03:38Z No. of bitstreams: 1 2015_tese_nbpinto.pdf: 9261753 bytes, checksum: 4bd9df04382dd73463d692c4c5fbd540 (MD5)<br>Approved for entry into archive by Erika Fernandes(erikaleitefernandes@gmail.com) on 2015-11-05T1

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10

Zhang, Yan. "Implementation of anti-apoptotic peptide aptamers in cell and "in vivo" models of Parkinson's disease." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0788.

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La maladie de Parkinson (PD) est considérée comme la deuxième maladie neurodégénérative la plus fréquente. L'examen post-mortem de patients parkinsoniens et des modèles physiologiques d’études de la maladie de Parkinson suggèrent la participation de la mort cellulaire programmée, l'inflammation et l'autophagie dues au stress oxydatif, à des mutations ou l’agrégation de protéines au sein des neurones DA. Les aptamères peptidiques sont de petites protéines combinatoires, consistitués d’une plateforme (dans notre cas, la thiorédoxine humaine, hTRX) et une boucle variable insérée dans le domaine a

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11

Jaillon, Catherine. "Intérêt et difficulté d'évaluation des peptides modulateurs de la transmission dopaminergique dans le traitement des dyskinésies chez des sujets parkinsoniens : étude d'un anti-CCKA, le SR27897B." Paris 5, 1999. http://www.theses.fr/1999PA05P189.

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Gschmack, Eva Maria. "Anti-Gehirn-Autoantikörper und deren Bedeutung bei Morbus Parkinson." Doctoral thesis, 2017. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-149348.

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Hintergrund: Die der Pathogenese von Morbus Parkinson (PD, Parkinson’s disease) zugrunde liegenden Mechanismen sind bis heute nur unvollständig verstanden. Insbesondere ist unklar, durch welche ursächlichen Faktoren Parkinson ausgelöst wird. Bei der HIV-Infektion treten bei vielen Patienten neurologische Störungen auf (HIV-Associated Neurological Disorders, HAND), die in der klinischen Symptomatik und der Lokalisation der betroffenen Gehirnareale dem Morbus Parkinson ähneln. Möglicherweise könnte eine Fehlregulation der Immunantwort eine Rolle als Auslöser beider Erkrankungen spielen. In diese

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Ferreira, Joaquim 1968. "Anti-parkinsonian drugs and sleep disorders in Parkinson s disease." Doctoral thesis, 2009. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000559261.

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Tese de doutoramento, Medicina (Neurologia), Universidade de Lisboa, Faculdade de Medicina, 2009<br>Sleep disturbances are a frequent and relevant clinical phenomenon for the management of Parkinson's disease (PD). It is estimated that 60% to 90% of the patients with PD complain of difficulties associated with sleep and these disorders can be categorized into those that involve nocturnal sleep and daytime manifestations such as excessive daytime sleepiness. The causes of sleep disorders in PD are considered to be multifactorial: related to the disease itself, to co-morbidity or ageing, or even

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Wu, Hyun-Ling, and 吳洵伶. "The Relationship between Different Types of Anti-Parkinson Drugs and Depression." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/95772928102013793040.

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碩士<br>國立臺北護理健康大學<br>健康事業管理研究所<br>103<br>Background: Due to the aging of society, Parkinson's disease (PD) population may increase in the future, resulting in increased health burden. In addition, PD is a chronic, degenerative, and has an unpredictable disease process which makes it a big challenge for patients, doctors and caregivers. Depression is the most common psychiatric complication in PD, and there are about 40-50% of PD patients who also have depression. Compared to PD patients without depression, quality of life for PD patients with depression will significantly reduce. Although PD se

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Lima, Beatriz Lopes Pires de. "Synthesis and Pharmacological Evaluation of Melanostatin Isosteres with Potential Anti-Parkinson Activity." Master's thesis, 2021. https://hdl.handle.net/10216/139054.

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Chang, Chia-Yu, та 張家瑜. "Detecting Parkinson Biomarkers of anti-α-Syn by Au-LSPR biosensors Based on Gold-nanoparticle Clusters". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/tuc3yq.

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碩士<br>國立中興大學<br>化學系所<br>102<br>We use gold nanoparticles to enhance localized surface plasmon resonance (LSPR) signal of Au-LSPR biosensor chips, which were made by our patented microwave plasma generator. This sandwich type hot-spot can detect the 3.8ng/mL α-synuclein antibody (anti-α-Syn), which is the biomarker for diagnosis of Parkinson’s disease. Among immunoassay protocol to modify (3-aminopropyl)trimethoxysilane (APTMS) glutaraldehyde (GA)、α-synuclein (α-Syn)、bovine serum albumin (BSA) and anti-α-Syn on the chip, we reduce time of APTMS modification process from 1 hour to 30 seconds by

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Ouerfelli-Éthier, Julie. "Les anti-saccades prédisent le fonctionnement cognitif dans le vieillissement normal et la maladie de Parkinson." Thèse, 2018. http://hdl.handle.net/1866/22092.

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Chi, Chen Hsien, and 紀政嫻. "The development and evaluation on drug delivery systems for anti-Parkinson drugs: nano-carriers for injection and transdermal delivery formulation." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/73171108164281215802.

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碩士<br>長庚大學<br>天然藥物研究所<br>97<br>Apomorphine is a non-selective agonist of D1 and D2 dopamine receptors. Apomorphine is a very effective drug in the management of ‘on-off’ motor response fluctuations in the treatment of Parkinson’s disease. The aim of this present work was to develop acoustically active lipid-coated microbubbles for encapsulation of both apomorphine hydrochloride and apomorphine base to circumvent these delivery problems. The lipid-coated microbubbles were prepared using coconut oil and perfluoropentane as the inner phase, which was emulsified by phospholipids and cholesterol. T

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Patrício, Alexandra Raquel Coelho. "Interplay between HIV and antiretroviral therapy in neurologic impairments." Master's thesis, 2016. http://hdl.handle.net/10316/33182.

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Trabalho final do 6º ano médico com vista à atribuição do grau de mestre (área científica de microbiologia e neurologia), apresentado à Faculdade de Medicina da Universidade de Coimbra<br>O síndrome da imunodeficiência adquirida (SIDA) é uma doença incurável que afeta milhões de pessoas em todo o mundo e é causada pelo vírus da imunodeficiência humana (VIH). 50% dos pacientes com VIH podem desenvolver uma patologia em paralelo, designada doenças neurocognitivas associadas ao VIH (do inglês HAND). O objetivo deste trabalho é destacar os mecanismos associados ao VIH que podem levar a défices neu

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Candeias, Emanuel Monteiro. "The amazing anti-type 2 diabetic drugs in neurodegeneration: the impact of exendin-4, liraglutide and linagliptin in type 2 diabetes, Alzheimer disease and Parkinson disease." Doctoral thesis, 2021. http://hdl.handle.net/10316/98734.

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Tese de Doutoramento em Biologia Experimental e Biomedicina / área Neurociências e Doença apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra.<br>Type 2 diabetes (T2D) is a noisy “silent killer”, which has already attained the status of a global pandemic, which affects millions of people spread to every corner of the world, with the aggravating that millions more are currently living with this disease without even knowing. Even so, more efforts have to be done to the awareness, understanding and treatment of T2D in order to avoid an uncontrolled developing of l

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Kwan, Cynthia. "Modulation of the 5-HT3 Receptor as a Novel Anti-Dyskinetic Target in Parkinson’s Disease." Thèse, 2017. http://hdl.handle.net/1866/20793.

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