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Rozprawy doktorskie na temat „Anticancer efficacy”

Autor: Grafiati

Data publikacji: 7 czerwca 2025

Data aktualizacji: 2 sierpnia 2025

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1

Haglund, Caroline. "Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications." Doctoral thesis, Uppsala universitet, Klinisk farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-150361.

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Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. A high correlation was seen when comparing the 50% inhibitory concentrations (IC50) from FMCA-GM with the IC50 from the established clonogenic assay (CFU-GM). In paper II, FMCA-GM was complemented with additional cell models, establishing a normal cell pa

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Hansson, Emma K. "Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170738.

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New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. The variability in myelosuppression was characterized in six different cytotoxic anticancer treatments to evaluate a model-based dose individualization approach utilizing neutrophil counts as a biomarker. The estimated impact of inter-oc

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Xia, Yixuan. "Anticancer efficacy and mechanism of action studies of the potent plant cycloheptapeptide compounds mavacyocines." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/817.

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Over the past 200 years, much attention has been paid to natural products for their great contribution in the industry of drug development as many of them have been shown effective against various diseased conditions in humans by virtue of their structural diversity and biological potency. Therefore, they are undeniably a rich resource for the discovery of novel bioactive compounds. To date, many of the mainstay anticancer agents often lead to undesirable side effects and/or develop rapid emergence of drug resistance. Therefore, new therapeutic remedies are desperately needed. In fact, many ac

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Maldonado, Arturo R. "Molecular Targeting and Enhancing Anticancer Efficacy of Oncolytic HSV-1 to Midkine Expressing Tumors." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1298041800.

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Parkkola, Hanna. "Hyaluronic acid-coated gold nanoparticles as an anticancer drug delivery system - Biological characterization and efficacy." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285100.

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Novel stategies are needed to improve the limited efficacy of current cancer therapies. High expectations are directed towards nanotechnology-based applications in cancer medicine. We have developed a drug delivery system based on hyaluronic acid (HA) coated gold nanoparticles (AuNPs) that targets CD44, a cell surface glycoprotein overexpressed by various cancer cells. This nanocarrier (EDS: Endor Drug Delivery System) provides a platform for the conjugation of anticancer agents for a more efficient cancer treatment. We show that the unique characteristics of AuNPs remain unchanged when the

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Du, Plessis-Stoman Debbie. "A combination of platinum anticancer drugs and mangiferin causes increased efficacy in cancer cell lines." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/d1016160.

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This thesis mainly deals with some biochemical aspects regarding the efficacy of novel platinum anticancer compounds alone and in combination with mangiferin, as part of a broader study in which both chemistry and biochemistry are involved. Various novel diamine and N-S donor chelate compounds of platinum II and IV have been developed in which factors such as stereochemistry, ligand exchange rate and biocompatibility were considered as additional parameters. In the first order testing, each of these compounds was tested with reference to their “killing” potential by comparing their rate of kil

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Sarwar, Md Shahid. "Elucidation of anticancer efficacy of ent-kaurane diterpenes through structure-activity relationship and mechanism of action studies." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/669.

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Colorectal cancer (CRC) is the third most prevalent and second leading causes of cancer-associated deaths globally. Over the last few decades, ent-kaurane diterpenes have been widely investigated for their anticancer potentials. Flexicaulin A (9) is a naturally occurring ent-kaurane. Previously, our lab modified the structure of 9 by replacing the C-11 hydroxyl group with carbonyl group and obtained a novel compound oxoflexicaulin A (11). However, anticancer activities and mechanistic pathway of these two compounds are yet to be explored. In the current thesis, we evaluated the cytotoxicity of

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Koot, Dwayne Jonathan. "Strategic pre-clinical development of Riminophenazines as resistance circumventing anticancer agents." Thesis, University of Pretoria, 2012. http://hdl.handle.net/2263/24163.

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Cancer is responsible for upward of 13% of human deaths. Contemporary chemotherapy of disseminated cancer is often thwarted by dose limiting systemic toxicity and by multi-drug resistance (MDR). Riminophenazines are a novel class of potential anticancer agents that possess a potent multi-mechanistic antineoplastic action. Apart from their broad action against intrinsic, non-classical resistance, Riminophenazines inhibit the action of Pgp and hypothetically all ABC transporters demonstrating their great utility against classical MDR. Considering that combination chemotherapy is the norm, the vi

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9

Koegle, Eric Richard. "Determining the Intracellular Localization and Efficacy of Novel Anticancer Agents in Human Breast Cancer Cell Lines Through the Use of Fluorescent Microscopy." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1234749487.

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Thesis (M.S.)--University of Toledo, 2008.<br>Typescript. "Submitted as partial fulfillments of the requirements for The Master of Science in Pharmaceutical Sciences in Pharmacology and Toxicology." "A thesis entitled"--at head of title. Bibliography: leaves 47-49.

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Soble, Michelle Joy 1961. "THE EFFECTS OF GLUTATHIONE DEPLETION BY L-BUTHIONINE-(S,R) SULFOXIMINE ON THE ANTITUMOR EFFICACY OF MODEL SULFHYDRYL-DEPENDENT ANTICANCER AGENTS (BSO)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276859.

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11

Dierickx, Karen. "Contribution to the study of the efficacy and the mechanism of action of the alkylating peptide prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF)." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210390.

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The search for more effective treatment strategies in melanoma led to many new innovative approaches aiming at different molecular targets. Chemotherapy still remains the most effective treatment and many efforts are put in order to improve targeting and delivery of the chemotherapeutic agents. Among these, peptide conjugates of anticancer drugs were designed to increase stability, cell penetration, specificity and accumulation in cancer cells. We as well as others evaluated such a conjugate, termed PSF (L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine-ethylester) in terms of its cytotoxicity i

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12

Sargeant, Aaron Matthew. "Preclinical Efficacy and Safety Evaluation of Novel Small-Molecule Targeted Agents for the Prevention and Treatment of Prostate Cancer." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243948876.

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Xie, Wei. "Transcription Inhibitor Lurbinectedin and Oncolytic Peptide LTX-401 trigger Immunogenic Cell Death and Synergize With Immune Checkpoint Blockade Lurbinectedin Synergizes With Immune Checkpoint Blockade To Generate Anticancer Immunity Tumor Lysis With LTX-401 Creates Anticancer Immunity Autophagy Induction by Thiostrepton Improves the Efficacy of Immunogenic Chemotherapy Oncolysis With DTT-205 and DTT-304 Generates Immunological Memory in Cured Animals." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL072.

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Le cancer est la deuxième cause de décès dans le monde. Malgré l'existence des traitements standards, le développement et la recherche de stratégies thérapeutiques innovantes et de médicaments est toujours nécessaire. La combinaison des médicaments induisant la mort cellulaire immunogène (ICD) et l'inhibition des points de contrôle immunitaire (ICB), semble être un protocole prometteur. Dans cette thèse, nous avons démontré que la Lurbinectedine, un inhibiteur de la transcription nouvellement approuvé pour le traitement du cancer du poumon récidivant, déclenche les caractéristiques de l'ICD da

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14

Dhellemmes, Alice. "Impact de la voie d'administration des anticancéreux sur la qualité de vie des patients : rôles des processus transactionnels et bénéfices d'une éducation thérapeutique." Thesis, Toulouse 2, 2019. http://www.theses.fr/2019TOU20020.

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La délocalisation de la chimiothérapie de l’hôpital vers le domicile et l’arrivée des anticancéreux oraux transforment radicalement le schéma thérapeutique des patients atteints de cancer. Ce dernier, inédit dans le domaine de l’oncologie, fait reposer l’efficacité du protocole sur la responsabilité entière du patient, de la délivrance du médicament à la gestion des effets secondaires. Cet éloignement de la sphère hospitalière et des soins de support amène les patients à gérer également seuls les conséquences psychologiques de la maladie. La première étude de cette thèse est transversale avec

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15

El, Founi Meriem. "Nanoparticules photosensibles pour un traitement anticancéreux plus efficace." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0325.

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Ce doctorat portait sur le développement de nanoparticules (NPs) photosensibles constituées d’un cœur photolysablepoly(acrylate d'o-nitrobenzyle) (polymère hydrophobe biocompatible - PANB) et d’une couronne basée sur un dérivé du dextrane (polysaccharide bactérien, hydrophile et biodégradable). Dans un premier temps, le PANB-N3 a été synthétisé par i) polymérisation radicalaire contrôlée (SET-LRP) de l’acrylate d’o-nitrobenzyle puis ii) modification chimique de l’extrémité de chaîne par une fonction azoture. En parallèle, le dextrane a été hydrophobisé par quelques chaînes grasses dotées d’un

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El, Founi Meriem. "Nanoparticules photosensibles pour un traitement anticancéreux plus efficace." Electronic Thesis or Diss., Université de Lorraine, 2018. http://www.theses.fr/2018LORR0325.

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Ce doctorat portait sur le développement de nanoparticules (NPs) photosensibles constituées d’un cœur photolysablepoly(acrylate d'o-nitrobenzyle) (polymère hydrophobe biocompatible - PANB) et d’une couronne basée sur un dérivé du dextrane (polysaccharide bactérien, hydrophile et biodégradable). Dans un premier temps, le PANB-N3 a été synthétisé par i) polymérisation radicalaire contrôlée (SET-LRP) de l’acrylate d’o-nitrobenzyle puis ii) modification chimique de l’extrémité de chaîne par une fonction azoture. En parallèle, le dextrane a été hydrophobisé par quelques chaînes grasses dotées d’un

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17

Minz, Aliva Prity. "Evaluation of Antioxidant and Anticancer Efficacy of Chitosan Based Nanoparticles." Thesis, 2015. http://ethesis.nitrkl.ac.in/7573/1/2015_Evaluation_of_antioxidant_Minz.pdf.

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Synthesis of chitosan based nanoparticle is a novel way for synthesis of nanoparticles by using biological sources. It is gaining attention due to its cost effective, ecofriendly and large scale production possibilities. In the present study six formulations are made taking chitosan as base material: chitosan-ascorbic acid(Cs-Aa), chitosan-ascorbic acid-Glucose(Cs-Aa-Glu), chitosan-Polyethyl glycol (Cs-PEG), chitosan-vitamin E (Cs-Vitamin E),chitosan-catechol (Cs-Cat),chitosan-Silver nanoparticles (Cs-AgNp)were taken to investigate their antioxidant property. The appearance of milky white solu

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18

Hung, Hsiao-Hsuan, and 洪筱媗. "Focused Ultrasound with Microbubbles Enhances the Accumulation and Efficacy of Anticancer Nanodrug in Different Stages of Brain Tumors." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/18857684154809030884.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>101<br>Purpose: Focused ultrasound (FUS) with microbubbles (MB) could enhance the delivery of nanodrug into brain tumors in rodent model. In this study, we investigated the difference of PEGylated liposomal doxorubicin (PLD) accumulation, tumor growth response after treatment and immunohistochemistry in different stages of brain tumor tissue-bearing with or without FUS/MBs. Methods and Materials: The ultrasound frequency and peak pressure at the focal zone were 0.5 MHz and 0.5 MPa, respectively. The doses of MB and PLD through IV injection were 100 ul/kg, and 6 mg/k

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Lin, Ya-Hui, and 林亞慧. "CRISPR/Cas9-based knockout of SQSTM1 affects cellular morphology, migration and anticancer compound efficacy in lung cancer cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/nu7d29.

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碩士<br>國立交通大學<br>分子醫學與生物工程研究所<br>106<br>Lung cancer is one of leading cause of cancer death in the world and Taiwan during the past few decades. Autophagy is a mechanism of the cells that disassembles aberrant components, organelles, and intracellular pathogens to maintain the cellular homeostasis. The process of autophagy is not simply a non-selective degradation pathway. Selective autophagy receptors have been identified which specifically mediate the selective autophagosomal degradation of a variety of cargoes. SQSTM1 is a pivotal selective autophagy receptor recruits LC3-containing autophag

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20

Li, Jia-Rong, and 李佳蓉. "Investigation of Focused Ultrasound Combined with Microbubbles to Enhance the Accumulation and Efficacy of Anticancer Nanodrug in Mouse Tumors." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/97695575253949853440.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>99<br>The main goal of drug delivery is to enhance the drug accumulation in tumor tissue in order to control the tumor growth, and to decrease drug concentration in other sites of the body to avoid side effect on normal tissues. Such treatment is so-called “targeted therapy.” High intensity focused ultrasound (HIFU) has been used for clinical therapy for years. Recently, it was found that the cavitation effect due to ultrasound sonication and ultrasound contrast agent was beneficial to local drug delivery. In this study, we used s.c. colon carcinoma CT-26 mic

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Chen, Cheng-Cheung, and 陳正忠. "A Study of Anticancer Efficacy of (-)-Epigallocatechin-3-Gallate (EGCG) Gold Nanoparticles: Evidence from Murine B16-F10 Melanoma Cells." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/36850212762937515127.

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博士<br>國立臺灣海洋大學<br>食品科學系<br>102<br>Malignant melanoma, the major fatal form of skin cancer, is an aggressive and refractory cancer derived from melanocytes. In recent years, the incidence of melanoma has been continuously increasing worldwide and becoming a huge public health issue. (-)-Epigallocatechin- 3-gallate (EGCG), the major bioactive constituent in green tea, has been reported to effectively inhibit the formation and development of tumors. However, high concentrations of EGCG leading to the death of normal cells, short half-life and clearance rate of EGCG limit its application. To maxim

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Taritla, Sidhartha. "Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species." Thesis, 2023. https://etd.iisc.ac.in/handle/2005/6149.

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Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved for treatment of cancer between the 1940s and the end of 2014 are comprised of either naturally occurring substances or compounds that were synthesized using those substances. The majority of bioactive chemicals are obtained from terrestrial microorganisms, and while the terrestrial environment is abundant in bioactive producers, the finding of new metabolites is withering. M

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Rocha, Luís Gabriel Borges. "Development of a novel photosensitizer for photodynamic therapy of cancer." Doctoral thesis, 2016. http://hdl.handle.net/10316/29825.

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Tese de doutoramento em Ciências Farmacêuticas, na especialidade de Biotecnologia Farmacêutica, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>Photodynamic Therapy (PDT) for cancer treatment is a safe and clinically-approved procedure that experienced great progresses over the last two decades. It is based on the interaction between a photosensitizer (PS) molecule, light and oxygen that react to generate reactive oxygen species (ROS). These ROS trigger a cascade of reactions that lead to the destruction of tumour cells and tumour vasculature. In comparison with the tradition

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